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Archives of Virology

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01.06.2022 | Original Article

Inhibitory activity and mechanism of silver nanoparticles against herpes simplex virus type 1

verfasst von: Xuanhe Pan, Yapeng Zhang, Yiming Zhao, Siqi Yao, Chaxiang Guan, Linqian Wang, Liyu Chen

Erschienen in: Archives of Virology | Ausgabe 8/2022

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Abstract

Herpes simplex virus type 1 (HSV-1) is a common pathogen that infects 50–90% of the world’s population and causes a variety of diseases, some of which can be life-threatening. Silver nanoparticles (AgNPs) have been shown to have broad-spectrum antiviral activity. In this study, we investigated the activity of AgNPs against HSV-1 and found that AgNPs effectively inhibited plaque formation and HSV-1 progeny production, reduced the genomic load, and interfered with HSV-1 mRNA expression and protein synthesis. Transmission electron microscopy showed that AgNPs interacted with HSV-1 and altered the shape of the viral particles. Furthermore, AgNPs affected the entry of HSV-1 into cells as well as their release and cell-to-cell spread. AgNPs were also found to downregulate the expression of pro-inflammatory cytokines upon HSV-1 infection. Combined treatment with AgNPs and acyclovir (ACV) confirmed that AgNPs significantly enhanced the inhibitory effect of ACV against HSV-1. Our findings may contribute to an understanding of the mechanism of the antiviral effect of AgNPs against HSV-1 and help to provide a theoretical basis for their clinical application.

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Titel: Inhibitory activity and mechanism of silver nanoparticles against herpes simplex virus type 1
verfasst von: Xuanhe Pan
Yapeng Zhang
Yiming Zhao
Siqi Yao
Chaxiang Guan
Linqian Wang
Liyu Chen
Publikationsdatum: 01.06.2022
Verlag: Springer Vienna
Erschienen in: Archives of Virology / Ausgabe 8/2022
Print ISSN: 0304-8608
Elektronische ISSN: 1432-8798
DOI: https://doi.org/10.1007/s00705-022-05467-x

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