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Magnetic Resonance Materials in Physics, Biology and Medicine

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01.10.2014 | Research Article

Initial clinical application of modified Dixon with flexible echo times: hepatic and pancreatic fat assessments in comparison with ¹H MRS

verfasst von: Roshan S. Livingstone, Paul Begovatz, Sabine Kahl, Bettina Nowotny, Klaus Straßburger, Guido Giani, Jürgen Bunke, Michael Roden, Jong-Hee Hwang

Erschienen in: Magnetic Resonance Materials in Physics, Biology and Medicine | Ausgabe 5/2014

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Abstract

Objects

Hepatic and pancreatic fat content become increasingly important for phenotyping of individuals with metabolic diseases. This study aimed to (1) evaluate hepatic fat fractions (HFF) and pancreatic fat fractions (PFF) using ¹H magnetic resonance spectroscopy (MRS) and the recently introduced fast mDixon method, and to examine body fat effects on HFF and PFF, (2) investigate regional differences in HFF and PFF by mDixon.

Materials and methods

HFF and PFF were quantified by mDixon with two flexible echo times and by single voxel ¹H MRS in 24 healthy subjects. The regional differences of PFF within the pancreas were assessed with mDixon. Abdominal visceral and subcutaneous fat was assessed by T1-weighted MRI at 3T.

Results

Both methods correlated well for quantification of HFF (r = 0.98, p < 0.0001) and PFF (r = 0.80, p < 0.0001). However, mDixon showed a higher low limit in HFF and PFF. PFF showed no regional differences using mDixon. In addition, both visceral and subcutaneous fat correlated with pancreatic fat, while only visceral fat correlated with liver fat, employing both ¹H MRS and mDixon.

Conclusion

The novel and fast two-point mDixon exhibits a good correlation with the gold-standard ¹H MRS for assessment of HFF and PFF, with limited sensitivity for assessing lower fat content.

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Titel: Initial clinical application of modified Dixon with flexible echo times: hepatic and pancreatic fat assessments in comparison with 1H MRS
verfasst von: Roshan S. Livingstone
Paul Begovatz
Sabine Kahl
Bettina Nowotny
Klaus Straßburger
Guido Giani
Jürgen Bunke
Michael Roden
Jong-Hee Hwang
Publikationsdatum: 01.10.2014
Verlag: Springer Berlin Heidelberg
Erschienen in: Magnetic Resonance Materials in Physics, Biology and Medicine / Ausgabe 5/2014
Print ISSN: 0968-5243
Elektronische ISSN: 1352-8661
DOI: https://doi.org/10.1007/s10334-013-0421-4

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Initial clinical application of modified Dixon with flexible echo times: hepatic and pancreatic fat assessments in comparison with ¹H MRS