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Supportive Care in Cancer

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01.02.2016 | Original Article

Inspiratory muscle training in allogeneic hematopoietic stem cell transplantation recipients: a randomized controlled trial

verfasst von: Gülşah Barğı, Meral Boşnak Güçlü, Zeynep Arıbaş, Şahika Zeynep Akı, Gülsan Türköz Sucak

Erschienen in: Supportive Care in Cancer | Ausgabe 2/2016

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Abstract

Purpose

Respiratory muscles are known to be weakened and are a cause of reduced exercise capacity in both recipients and candidates of allogeneic hematopoietic stem cell transplantation (allo-HSCT). Effects of inspiratory muscle training (IMT) in this patient population have not been comprehensively investigated so far. The current study was planned to investigate the effects of IMT during allo-HSCT on early transplantation-related outcomes.

Methods

This is a prospective, randomized controlled, double-blinded study. Thirty-eight allo-HSCT recipients, 20 of whom were allocated to the treatment group (40 % of maximal inspiratory pressure (MIP)) and 18 to the control group (5 % of MIP), received IMT for 6 weeks. Pulmonary functions, dyspnea, respiratory (MIP, maximal expiratory pressure (MEP)) and peripheral muscle strength, maximal exercise capacity using modified incremental shuttle walking test (MISWT) and submaximal exercise capacity using 6-min walking test (6-MWT), fatigue, depression, and quality of life were evaluated before and after IMT.

Results

The distance covered during MISWT (61.94 m) and 6-MWT (29.30 m), respiratory muscle strength (MIP 34.99 cmH₂O, MEP 12.69 cmH₂O), depression (−0.95), and modified Borg dyspnea scores (−0.11) showed a significant improvement in the treatment group compared to controls (p ≤ 0.05).

Conclusions

Inspiratory muscle training is a safe and effective intervention which improves respiratory muscle strength and exercise capacity and decreases depression and dyspnea in allo-HSCT recipients. These positive changes might be further enhanced by prolonging the duration of training or inclusion of more recipients with inspiratory muscle weakness.

Clinical trial registration number: NCT02270346

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Titel: Inspiratory muscle training in allogeneic hematopoietic stem cell transplantation recipients: a randomized controlled trial
verfasst von: Gülşah Barğı
Meral Boşnak Güçlü
Zeynep Arıbaş
Şahika Zeynep Akı
Gülsan Türköz Sucak
Publikationsdatum: 01.02.2016
Verlag: Springer Berlin Heidelberg
Erschienen in: Supportive Care in Cancer / Ausgabe 2/2016
Print ISSN: 0941-4355
Elektronische ISSN: 1433-7339
DOI: https://doi.org/10.1007/s00520-015-2825-3

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Springer Medizin

Inspiratory muscle training in allogeneic hematopoietic stem cell transplantation recipients: a randomized controlled trial

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Purpose

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Conclusions

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Conclusions

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