Skip to main content
main-content

01.11.2010 | GENETIC EPIDEMIOLOGY | Ausgabe 11/2010

European Journal of Epidemiology 11/2010

Interaction between the C(-344)T polymorphism of CYP11B2 and alcohol consumption on the risk of essential hypertension in a Chinese Mongolian population

Zeitschrift:
European Journal of Epidemiology > Ausgabe 11/2010
Autoren:
Xing-Qiang Pan, Yong-Hong Zhang, Yong-Yue Liu, Wei-Jun Tong

Abstract

The present study aimed to explore gene–gene and gene-environment interactions among three candidate genes and several environmental risk factors, and their impacts on hypertension in Chinese Mongolian population. A cross-sectional study was conducted in 2003–2004 among 1,575 Mongolian people in Tongliao City of Inner Mongolia, China. Epidemiologic and clinical data and blood samples were obtained from subjects. Multifactor dimensionality reduction (MDR) and logistic regression were used to analyze gene–gene and gene-environment interactions. The MDR model indicated a significant interactions among the CYP11B2 gene C(-344)T polymorphism, body mass index, age, and alcohol consumption on the risk of hypertension, with a cross-validation consistency of 10 of 10 and a prediction error of 34% (P < 0.001). Logistic regression suggested alcohol consumption (≥200 g/d) was associated with an OR of 2.4 (95% CI, 1.6–3.5) for hypertension. When stratified by the CYP11B2 genotype, the estimated OR was 1.2 (95% CI, 0.5–3.0) on hypertension for the CC genotype group, but was 3.0 (95% CI, 1.5–5.7) and 2.9 (95% CI, 1.4–5.7) for the TC and TT genotype groups, respectively. A significant interaction between the CYP11B2 genotype and alcohol consumption was also found by the logistic models (P crude = 0.035, P adjusted = 0.048). This study demonstrates a significant interaction between the CYP11B2 genotype and alcohol consumption on the risk of hypertension in Chinese Mongolian population.

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

★ PREMIUM-INHALT
e.Med Interdisziplinär

Mit e.Med Interdisziplinär erhalten Sie Zugang zu allen CME-Fortbildungen und Fachzeitschriften auf SpringerMedizin.de. Zusätzlich können Sie eine Zeitschrift Ihrer Wahl in gedruckter Form beziehen – ohne Aufpreis.

Weitere Produktempfehlungen anzeigen
Literatur
Über diesen Artikel

Weitere Artikel der Ausgabe 11/2010

European Journal of Epidemiology 11/2010 Zur Ausgabe
  1. Das kostenlose Testabonnement läuft nach 14 Tagen automatisch und formlos aus. Dieses Abonnement kann nur einmal getestet werden.