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Brain Structure and Function

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06.10.2016 | Original Article

Interhemispheric resting-state functional connectivity of the claustrum in the awake and anesthetized states

verfasst von: Jared B. Smith, Zhifeng Liang, Glenn D. R. Watson, Kevin D. Alloway, Nanyin Zhang

Erschienen in: Brain Structure and Function | Ausgabe 5/2017

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Abstract

The claustrum is a brain region whose function remains unknown, though many investigators suggest it plays a role in conscious attention. Resting-state functional magnetic resonance imaging (RS-fMRI) has revealed how anesthesia alters many functional connections in the brain, but the functional role of the claustrum with respect to the awake versus anesthetized states remains unknown. Therefore, we employed a combination of seed-based RS-fMRI and neuroanatomical tracing to reveal how the anatomical connections of the claustrum are related to its functional connectivity during quiet wakefulness and the isoflurane-induced anesthetic state. In awake rats, RS-fMRI indicates that the claustrum has interhemispheric functional connections with the mediodorsal thalamus (MD) and medial prefrontal cortex (mPFC), as well as other known connections with cortical areas that correspond to the connections revealed by neuroanatomical tracing. During deep isoflurane anesthesia, the functional connections of the claustrum with mPFC and MD were significantly attenuated, while those with the rest of cortex were not significantly altered. These changes in claustral functional connectivity were also observed when seeds were placed in mPFC or MD during RS-fMRI comparisons of the awake and deeply anesthetized states. Collectively, these data indicate that the claustrum has functional connections with mPFC and MD-thalamus that are significantly lessened by anesthesia.

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Titel: Interhemispheric resting-state functional connectivity of the claustrum in the awake and anesthetized states
verfasst von: Jared B. Smith
Zhifeng Liang
Glenn D. R. Watson
Kevin D. Alloway
Nanyin Zhang
Publikationsdatum: 06.10.2016
Verlag: Springer Berlin Heidelberg
Erschienen in: Brain Structure and Function / Ausgabe 5/2017
Print ISSN: 1863-2653
Elektronische ISSN: 1863-2661
DOI: https://doi.org/10.1007/s00429-016-1323-9

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