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29.05.2018 | Original Article | Ausgabe 3/2018

Sport Sciences for Health 3/2018

Intermittent exercise improves working memory and locomotor activity by attenuating oxidative stress in the prefrontal cortex and cerebellum of ovariectomized rats

Zeitschrift:
Sport Sciences for Health > Ausgabe 3/2018
Autoren:
Saidah Rauf, Marsetyawan Soesatyo, Denny Agustiningsih, Ginus Partadiredja

Abstract

Objectives

The aim of the present study was to investigate the effects of moderate- or high-intensity intermittent exercise (MIIE/HIIE) on the oxidative status of the prefrontal cortex and cerebellum, locomotor activities, as well as working memory performances of rats.

Materials and Methods

Twenty female rats were divided into four groups: (1) sham-operated (Sham), (2) ovariectomy (OVX), (3) OVX + MIIE, and (4) OVX + HIIE groups. The OVX + MIIE and OVX + HIIE groups exercised on a rat treadmill for 7 weeks. The assessment on the working memory performances and locomotor activities were conducted on the last day of the exercise period. Levels of superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPX) enzyme activities, as well as levels of hydrogen peroxidase (H2O2), and malondialdehyde (MDA) in the prefrontal cortex and cerebellum were determined using a spectrophotometer.

Results

Ovariectomy depressed the working memory, locomotor activities, the levels of SOD, CAT, and GPX enzyme activities, and elevated the levels of H2O2, and MDA in the prefrontal cortex and cerebellum.

Conclusion

MIIE and HIIE exert their neuroprotective effects by reducing oxidative stress in the brain of ovariectomized rats. HIIE has more potent effects than MIIE in suppressing the levels of oxidants in the prefrontal cortex and cerebellum by increasing the levels of SOD and CAT activities more than MIIE.

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