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Sport Sciences for Health
Erschienen in: Sport Sciences for Health 3/2018

29.05.2018 | Original Article

Intermittent exercise improves working memory and locomotor activity by attenuating oxidative stress in the prefrontal cortex and cerebellum of ovariectomized rats

verfasst von: Saidah Rauf, Marsetyawan Soesatyo, Denny Agustiningsih, Ginus Partadiredja

Erschienen in: Sport Sciences for Health | Ausgabe 3/2018

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Abstract

Objectives

The aim of the present study was to investigate the effects of moderate- or high-intensity intermittent exercise (MIIE/HIIE) on the oxidative status of the prefrontal cortex and cerebellum, locomotor activities, as well as working memory performances of rats.

Materials and Methods

Twenty female rats were divided into four groups: (1) sham-operated (Sham), (2) ovariectomy (OVX), (3) OVX + MIIE, and (4) OVX + HIIE groups. The OVX + MIIE and OVX + HIIE groups exercised on a rat treadmill for 7 weeks. The assessment on the working memory performances and locomotor activities were conducted on the last day of the exercise period. Levels of superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPX) enzyme activities, as well as levels of hydrogen peroxidase (H2O2), and malondialdehyde (MDA) in the prefrontal cortex and cerebellum were determined using a spectrophotometer.

Results

Ovariectomy depressed the working memory, locomotor activities, the levels of SOD, CAT, and GPX enzyme activities, and elevated the levels of H2O2, and MDA in the prefrontal cortex and cerebellum.

Conclusion

MIIE and HIIE exert their neuroprotective effects by reducing oxidative stress in the brain of ovariectomized rats. HIIE has more potent effects than MIIE in suppressing the levels of oxidants in the prefrontal cortex and cerebellum by increasing the levels of SOD and CAT activities more than MIIE.
Literatur
1.
Genazzani A, Pluchino N, Luisi S, Luisi L (2007) Estrogen, cognition and female ageing. Hum Reprod Update 13:175–187CrossRef
2.
World Health Organization (2007) Women, ageing and health: a framework for action focus on gender. WHO Press, Geneva
3.
Parker WH, Broder MS, Liu Z, Shoupe D, Farquhar C, Berek JS (2005) Ovarian conservation at the time of hysterectomy for benign disease. Obstet Gynecol 2005 106:219–226CrossRef
4.
Petrovska S, Dejanova B, Jurisic V (2012) Estrogens: mechanisms of neuroprotective effects J Physiol Biochem 68:455–460CrossRef
5.
McEwen BS, Alves SE (1999) Estrogen actions in the central nervous system. Endocr Rev 20:279–307PubMed
6.
de Chaves G, Moretti M, Castro AA et al (2009) Effects of long-term ovariectomy on anxiety and behavioral despair in rats. Physiol Behav 97:420–425CrossRef
7.
Baeza I, De Castro NM, Giménez-Llort L, De la Fuente M (2010) Ovariectomy, a model of menopause in rodents, causes a premature aging of the nervous and immune systems. J Neuroimmunol 219:90–99CrossRef
8.
Signorelli SS, Neri S, Sciacchitano S et al (2006) Behaviour of some indicators of oxidative stress in postmenopausal and fertile women. Maturitas 53:77–82CrossRef
9.
Tan MN, Kartal M, Guldal D (2014) The effect of physical activity and body mass index on menopausal symptoms in Turkish women: a cross-sectional study in primary care. BMC Womens Health 14:38CrossRef
10.
Kaidah S, Soejono SK, Partadiredja G (2016) Exercise improves hippocampal estrogen and spatial memory of ovariectomized rats. Bratisl Med J 117:94–99CrossRef
11.
Mishr N, Mishra VN, Devanshi (2011) Exercise beyond menopause: dos and don’ts. J Midlife Health 2:51–56
12.
Justine M, Azizan A, Hassan V, Salleh Z, Manaf H (2013) Barriers to participation in physical activity and exercise among middle-aged and elderly individuals. Singap Med J 54:581–586CrossRef
13.
Coquart JBJ, Lemaire C, Dubart AE, Luttembacher DP, Douillard C, Garcin M (2008) Intermittent versus continuous exercise: effects of perceptually lower exercise in obese women. Med Sci Sports Exerc 40:1546–1553CrossRef
14.
Gibala MJ, McGee SL (2008) Metabolic adaptations to short-term high-intensity interval training: a little pain for a lot of gain? Exerc Sport Sci Rev 36:58–63CrossRef
15.
Racil G, Ounis OB, Hammouda O et al (2013) Effects of high vs. moderate exercise intensity during interval training on lipids and adiponectin levels in obese young females. Eur J Appl Physiol 113:2531–2540CrossRef
16.
17.
Afzalpour ME, Chadorneshin HT, Foadoddini M, Eivari HA (2015) Comparing interval and continuous exercise training regimens on neurotrophic factors in rat brain. Physiol Behav 147:78–83CrossRef
18.
Agustiningsih D, Soejono SK, Soesatyo MHNE., Prakosa D (2015) Exercise induces the synthesis of estrogen in ovariectomized Sprague–Dawley rats ventricular myocardium trough increase expression of CYP19 aromatase. Sport Sci Health 11:337–343CrossRef
19.
Brooks GA, White TP (1978) Determination of metabolic and heart rate responses of rats to treadmill exercise. J Appl Physiol Respir Environ Exerc Physiol 45:1009–1015PubMed
20.
Hritcu L, Stefan M, Brandsch R, Mihasan M (2013) 6-Hydroxy-l-nicotine from arthrobacter nicotinovorans sustain spatial memory formation by decreasing brain oxidative stress in rats. J Physiol Biochem 69:25–34CrossRef
21.
Marques-Aleixo I, Santos-Alves E, Balca MM et al (2015) Physical exercise improves brain cortex and cerebellum mitochondrial bioenergetics and alters apoptotic, dynamic and auto(mito)phagy markers. Neuroscience 301:480–495CrossRef
22.
Iwai K, Nakaya N, Kawasaki Y, Matsue H (2002) Antioxidative functions of natto, a kind of fermented soybeans: effect on LDL oxidation and lipid metabolism in cholesterol-fed rats. J Agric Food Chem 50:3597–3601CrossRef
23.
Gülçin I, Küfrevioǧlu ÖI, Oktay M, Büyükokuroǧlu ME (2004) Antioxidant, antimicrobial, antiulcer and analgesic activities of nettle (Urtica dioica L.). J Ethnopharmacol 90:205–215CrossRef
24.
Singh RP, Murthy KNC, Jayaprakasha GK (2002) Studies on the antioxidant activity of pomegranate (Punica granatum) peel and seed extracts using in vitro models. J Agric Food Chem 50:81–86CrossRef
25.
Rauf S, Soejono SK, Partadiredja G (2015) Effects of treadmill exercise training on cerebellar estrogen and estrogen receptors, serum estrogen, and motor coordination performance of ovariectomized rats. Iran J Basic Med Sci 18:587–592PubMedPubMedCentral
26.
Behr GA, Schnorr CE, Simoes-Pires A, Motta LLD, Frey BN, Moreira JCF (2012) Increased cerebral oxidative damage and decreased antioxidant defenses in ovariectomized and sham-operated rats supplemented with vitamin A. Cell Biol Toxicol 28:317–330CrossRef
27.
Ciobica A, Olteanu Z, Padurariu M, Hritcu L (2012) The effects of pergolide on memory and oxidative stress in a rat model of Parkinson’s disease. J Physiol Biochem 68:59–69CrossRef
28.
Borrás C, Gambini J, Gómez-Cabrera MC et al (2005) 17β-oestradiol up-regulates longevity-related, antioxidant enzyme expression via the ERK1 and ERK2[MAPK]/NFЌB cascade. Aging Cell 4:113–118CrossRef
29.
Vina J, Gambini J, Lopez-GruesoR (2011) Females live longer than males: role of oxidative stress. Curr Pharm Des 17:3959–3965CrossRef
30.
Evsen MS, Ozler A, Gocmez C et al (2013) Effects of estrogen, estrogen/progesteron combination and genistein treatments on oxidant/antioxidant status in the brain of ovariectomized rats. Eur Rev Med Pharmacol Sci 17:1869–1873PubMed
31.
Aksu I, Topcu A, Camsari UM, Acikgoz O (2009) Effect of acute and chronic exercise on oxidant–antioxidant equilibrium in rat hippocampus, prefrontal cortex and striatum. Neurosci Lett 452:281–285CrossRef
32.
Oliveira PJ, Moreira PI (2012) Physical exercise as a possible strategy for brain protection: evidence from mitochondrial-mediated mechanisms. Prog Neurobiol 99:149–162CrossRef
33.
Pingitore A, Lima GPP, Mastorci F, Quinones A, Iervasi G, Vassalle C (2015) Exercise and oxidative stress: potential effects of antioxidant dietary strategies in sports. Nutrition 31:916–922CrossRef
34.
Rattan SI (2004) Aging, anti-aging, and hormesis. Mech Ageing Dev 125:285–289CrossRef
35.
Radak Z, Marton O, Nagy E, Koltai E, Goto S (2013) The complex role of physical exercise and reactive oxygen species on brain. J Sport Helath Sci 2:87–93CrossRef
36.
Daud DM, Karim AAH, Mohammad M, Hamid NAA, Ngah WZW (2006) Effect of exercise intensity on antioxidant enzymatic activities in sedentary adults. Malay J Biochem Mol Biol 13:37–47
37.
Radak Z, Ishihara K, Tekus E et al (2017) Exercise, oxidants, and antioxidants change the shape of the bell-shaped hormesis curve. Redox Biol 12:285–290CrossRef
38.
Melisa A, Bradley-Whitman MA, Timmons MD (2014) Nucleic acid oxidation: an early feature of Alzheimer’s disease. J Neurochem 128:294–304CrossRef
39.
Liu J, Head E, Gharib AM (2002) Memory loss in old rats is associated with brain mitochondrial decay and RNA/DNA oxidation: partial reversal by feeding acetyl-l-carnitine and/or R-α-lipoic acid. PNAS 99:2356–2361CrossRef
40.
Liu R, Liu IY, Bi X (2003) Reversal of age-related learning deficits and brain oxidative stress in mice with superoxide dismutase/catalase mimetics. PNAS 100:8526–8531CrossRef
41.
Garcia PC, Real CC, Ferreira AFB, Alouche SR, Britto LRG, Pires RS (2012) Different protocols of physical exercise produce different effects on synaptic and structural proteins in motor areas of the rat brain. Brain Res 1456:36–48CrossRef
Metadaten
Titel
Intermittent exercise improves working memory and locomotor activity by attenuating oxidative stress in the prefrontal cortex and cerebellum of ovariectomized rats
verfasst von
Saidah Rauf
Marsetyawan Soesatyo
Denny Agustiningsih
Ginus Partadiredja
Publikationsdatum
29.05.2018
Verlag
Springer Milan
Erschienen in
Sport Sciences for Health / Ausgabe 3/2018
Print ISSN: 1824-7490
Elektronische ISSN: 1825-1234
DOI
https://doi.org/10.1007/s11332-018-0470-1

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