Skip to main content
Erschienen in: Archives of Orthopaedic and Trauma Surgery 10/2022

03.08.2021 | Trauma Surgery

Intertrochanteric fracture fixation in solid organ transplant patients: outcomes and survivorship

verfasst von: Michael J. VanWagner, Steven B. Porter, Aaron C. Spaulding, Glenn G. Shi, Benjamin K. Wilke, Cameron K. Ledford

Erschienen in: Archives of Orthopaedic and Trauma Surgery | Ausgabe 10/2022

Einloggen, um Zugang zu erhalten

Abstract

Background

Solid organ transplantation (SOT) recipients have complex medical and surgical risk factors; however, the outcomes of these patients undergoing surgical fixation of hip fractures are unknown. This study sought to evaluate SOT patients’ outcomes and survivorship after intertrochanteric (IT) fracture fixation.

Methods

A retrospective review identified 12 SOT patients who underwent cephalomedullary (CMN) nail fixation for IT fractures and were matched (1:2) to a cohort of 24 non-SOT IT fracture patients. Perioperative results and complications, mortality/patient survivorship, and clinical outcomes were compared between the cohorts.

Results

The time from presentation to surgical fixation was within 48 h of presentation for the non-SOT patients, while only 75% of SOT patients underwent surgery within 48 h of presentation (p = 0.034). The 90-day readmission rate for SOT patients was 25% versus 13% in the non-SOT group (p = 0.38). Similarly, the SOT cohort experienced a higher rate of major medical complication (25% vs. 13%, p = 0.38). There were two (16%) reoperations in the SOT group and three (13%) in the non-SOT matched group (p = 0.99). Respectively, the 90-day and 1-year estimated patient survivorship was similar between the two cohorts: SOT patients with 92% (95% CI 54–99%) and 73% (95% CI 24–93%) versus 86% (95% CI 62–95%) and 72% (95% CI 47–86%, HR 0.92, 95% CI 0.18–4.62, p = 0.92) in non-SOT patients.

Conclusion

SOT patients who underwent CMN fixation for IT fractures required more time from hospital presentation to surgical management than non-SOT patients. Although not statistically significant, SOT patients demonstrated more acute complications and readmissions, but similar mortality compared to those without transplant.
Literatur
1.
Zurück zum Zitat Black CK, Termanini KM, Aguirre O, Hawksworth JS, Sosin M (2018) Solid organ transplantation in the 21st century. Ann Transl Med 6(20):409CrossRef Black CK, Termanini KM, Aguirre O, Hawksworth JS, Sosin M (2018) Solid organ transplantation in the 21st century. Ann Transl Med 6(20):409CrossRef
2.
Zurück zum Zitat OPTN/SRTR 2018 Annual data report: introduction (2020) Am J Transplant 20 Suppl s1:11–19. OPTN/SRTR 2018 Annual data report: introduction (2020) Am J Transplant 20 Suppl s1:11–19.
3.
Zurück zum Zitat Stein E, Ebeling P, Shane E (2007) Post-transplantation osteoporosis. Endocrinol Metab Clin North Am 36(4):937–63 viiiCrossRef Stein E, Ebeling P, Shane E (2007) Post-transplantation osteoporosis. Endocrinol Metab Clin North Am 36(4):937–63 viiiCrossRef
4.
Zurück zum Zitat Edwards BJ, Desai A, Tsai J, Du H, Edwards GR, Bunta AD, Hahr A, Abecassis M, Sprague S (2011) Elevated incidence of fractures in solid-organ transplant recipients on glucocorticoid-sparing immunosuppressive regimens. J Osteoporos 2011:591793CrossRef Edwards BJ, Desai A, Tsai J, Du H, Edwards GR, Bunta AD, Hahr A, Abecassis M, Sprague S (2011) Elevated incidence of fractures in solid-organ transplant recipients on glucocorticoid-sparing immunosuppressive regimens. J Osteoporos 2011:591793CrossRef
5.
Zurück zum Zitat Cohen A, Sambrook P, Shane E (2004) Management of bone loss after organ transplantation. J Bone Miner Res 19(12):1919–1932CrossRef Cohen A, Sambrook P, Shane E (2004) Management of bone loss after organ transplantation. J Bone Miner Res 19(12):1919–1932CrossRef
6.
Zurück zum Zitat Stein EM, Ortiz D, Jin Z, McMahon DJ, Shane E (2011) Prevention of fractures after solid organ transplantation: a meta-analysis. J Clin Endocrinol Metab 96(11):3457–3465CrossRef Stein EM, Ortiz D, Jin Z, McMahon DJ, Shane E (2011) Prevention of fractures after solid organ transplantation: a meta-analysis. J Clin Endocrinol Metab 96(11):3457–3465CrossRef
7.
Zurück zum Zitat Maalouf NM, Shane E (2005) Osteoporosis after solid organ transplantation. J Clin Endocrinol Metab 90(4):2456–2465CrossRef Maalouf NM, Shane E (2005) Osteoporosis after solid organ transplantation. J Clin Endocrinol Metab 90(4):2456–2465CrossRef
8.
Zurück zum Zitat Jalava T, Sarna S, Pylkkänen L, Mawer B, Kanis JA, Selby P, Davies M, Adams J, Francis RM, Robinson J, McCloskey E (2003) Association between vertebral fracture and increased mortality in osteoporotic patients. J Bone Miner Res 18(7):1254–1260CrossRef Jalava T, Sarna S, Pylkkänen L, Mawer B, Kanis JA, Selby P, Davies M, Adams J, Francis RM, Robinson J, McCloskey E (2003) Association between vertebral fracture and increased mortality in osteoporotic patients. J Bone Miner Res 18(7):1254–1260CrossRef
9.
Zurück zum Zitat von Friesendorff M, McGuigan FE, Wizert A, Rogmark C, Holmberg AH, Woolf AD, Akesson K (2016) Hip fracture, mortality risk, and cause of death over two decades. Osteoporos Int 27(10):2945–2953CrossRef von Friesendorff M, McGuigan FE, Wizert A, Rogmark C, Holmberg AH, Woolf AD, Akesson K (2016) Hip fracture, mortality risk, and cause of death over two decades. Osteoporos Int 27(10):2945–2953CrossRef
10.
Zurück zum Zitat Guzon-Illescas O, Perez Fernandez E, Crespí Villarias N, Quirós Donate FJ, Peña M, Alonso-Blas C, García-Vadillo A, Mazzucchelli R (2019) Mortality after osteoporotic hip fracture: incidence, trends, and associated factors. J Orthop Surg Res 14(1):203CrossRef Guzon-Illescas O, Perez Fernandez E, Crespí Villarias N, Quirós Donate FJ, Peña M, Alonso-Blas C, García-Vadillo A, Mazzucchelli R (2019) Mortality after osteoporotic hip fracture: incidence, trends, and associated factors. J Orthop Surg Res 14(1):203CrossRef
11.
Zurück zum Zitat Nickel BT, Ledford CK, Watters TS, Wellman SS, Bolognesi MP (2015) Arthroplasty in organ transplant patients. Arthroplast Today 1(2):41–44CrossRef Nickel BT, Ledford CK, Watters TS, Wellman SS, Bolognesi MP (2015) Arthroplasty in organ transplant patients. Arthroplast Today 1(2):41–44CrossRef
12.
Zurück zum Zitat Cavanaugh PK, Chen AF, Rasouli MR, Post ZD, Orozco FR, Ong AC (2015) Total joint arthroplasty in transplant recipients: in-hospital adverse outcomes. J Arthroplast 30(5):840–845CrossRef Cavanaugh PK, Chen AF, Rasouli MR, Post ZD, Orozco FR, Ong AC (2015) Total joint arthroplasty in transplant recipients: in-hospital adverse outcomes. J Arthroplast 30(5):840–845CrossRef
13.
Zurück zum Zitat Ledford CK, Watters TS, Wellman SS, Attarian DE, Bolognesi MP (2014) Risk versus reward: total joint arthroplasty outcomes after various solid organ transplantations. J Arthroplast 29(8):1548–1552CrossRef Ledford CK, Watters TS, Wellman SS, Attarian DE, Bolognesi MP (2014) Risk versus reward: total joint arthroplasty outcomes after various solid organ transplantations. J Arthroplast 29(8):1548–1552CrossRef
14.
Zurück zum Zitat Mundi S, Pindiprolu B, Simunovic N, Bhandari M (2014) Similar mortality rates in hip fracture patients over the past 31 years. Acta Orthop 85(1):54–59CrossRef Mundi S, Pindiprolu B, Simunovic N, Bhandari M (2014) Similar mortality rates in hip fracture patients over the past 31 years. Acta Orthop 85(1):54–59CrossRef
15.
Zurück zum Zitat Erlichman R, Kolodychuk N, Gabra JN, Dudipala H, Maxhimer B, DiNicola N, Elias JJ (2021) Prior admissions as a risk factor for readmission in patients surgically treated for femur fractures: implications for a potential hip fracture bundle. Geriatr Orthop Surg Rehabil 25(12):2151459321996169 Erlichman R, Kolodychuk N, Gabra JN, Dudipala H, Maxhimer B, DiNicola N, Elias JJ (2021) Prior admissions as a risk factor for readmission in patients surgically treated for femur fractures: implications for a potential hip fracture bundle. Geriatr Orthop Surg Rehabil 25(12):2151459321996169
16.
Zurück zum Zitat Bia M (2008) Evaluation and management of bone disease and fractures post transplant. Transplant Rev (Orlando) 22(1):52–61CrossRef Bia M (2008) Evaluation and management of bone disease and fractures post transplant. Transplant Rev (Orlando) 22(1):52–61CrossRef
17.
Zurück zum Zitat Della Rocca GJ, Moylan KC, Crist BD, Volgas DA, Stannard JP, Mehr DR (2013) Comanagement of geriatric patients with hip fractures: a retrospective, controlled, cohort study. Geriatr Orthop Surg Rehabil 4(1):10–15CrossRef Della Rocca GJ, Moylan KC, Crist BD, Volgas DA, Stannard JP, Mehr DR (2013) Comanagement of geriatric patients with hip fractures: a retrospective, controlled, cohort study. Geriatr Orthop Surg Rehabil 4(1):10–15CrossRef
18.
Zurück zum Zitat Pincus D, Ravi B, Wasserstein D, Huang A, Paterson JM, Nathens AB, Kreder HJ, Jenkinson RJ, Wodchis WP (2017) Association between wait time and 30-day mortality in adults undergoing hip fracture surgery. JAMA 318(20):1994–2003CrossRef Pincus D, Ravi B, Wasserstein D, Huang A, Paterson JM, Nathens AB, Kreder HJ, Jenkinson RJ, Wodchis WP (2017) Association between wait time and 30-day mortality in adults undergoing hip fracture surgery. JAMA 318(20):1994–2003CrossRef
19.
Zurück zum Zitat Bohl DD, Basques BA, Golinvaux NS, Miller CP, Baumgaertner MR, Grauer JN (2014) Extramedullary compared with intramedullary implants for intertrochanteric hip fractures: thirty-day outcomes of 4432 procedures from the ACS NSQIP database. J Bone Jt Surg Am 96(22):1871–1877CrossRef Bohl DD, Basques BA, Golinvaux NS, Miller CP, Baumgaertner MR, Grauer JN (2014) Extramedullary compared with intramedullary implants for intertrochanteric hip fractures: thirty-day outcomes of 4432 procedures from the ACS NSQIP database. J Bone Jt Surg Am 96(22):1871–1877CrossRef
20.
Zurück zum Zitat Navale SM, Szubski CR, Klika AK, Schiltz NK, Desai PP, Barsoum WK (2017) The impact of solid organ transplant history on inpatient complications, mortality, length of stay, and cost for primary total hip arthroplasty admissions in the United States. J Arthroplast 32(4):1107-1116.e1CrossRef Navale SM, Szubski CR, Klika AK, Schiltz NK, Desai PP, Barsoum WK (2017) The impact of solid organ transplant history on inpatient complications, mortality, length of stay, and cost for primary total hip arthroplasty admissions in the United States. J Arthroplast 32(4):1107-1116.e1CrossRef
21.
Zurück zum Zitat Klatt BA, Steele GD, Fedorka CJ, Sánchez AI, Chen AF, Crossett LS (2013) Solid organ transplant patients experience high rates of infection and other complications after total knee arthroplasty. J Arthroplast 28(6):960–963CrossRef Klatt BA, Steele GD, Fedorka CJ, Sánchez AI, Chen AF, Crossett LS (2013) Solid organ transplant patients experience high rates of infection and other complications after total knee arthroplasty. J Arthroplast 28(6):960–963CrossRef
22.
Zurück zum Zitat Chalmers BP, Ledford CK, Statz JM, Perry KI, Mabry TM, Hanssen AD, Abdel MP (2016) Survivorship after primary total hip arthroplasty in solid-organ transplant patients. J Arthroplast 31(11):2525–2529CrossRef Chalmers BP, Ledford CK, Statz JM, Perry KI, Mabry TM, Hanssen AD, Abdel MP (2016) Survivorship after primary total hip arthroplasty in solid-organ transplant patients. J Arthroplast 31(11):2525–2529CrossRef
23.
Zurück zum Zitat Ledford CK, Statz JM, Chalmers BP, Perry KI, Hanssen AD, Abdel MP (2017) Revision total hip and knee arthroplasties after solid organ transplant. J Arthroplast 32(5):1560–1564CrossRef Ledford CK, Statz JM, Chalmers BP, Perry KI, Hanssen AD, Abdel MP (2017) Revision total hip and knee arthroplasties after solid organ transplant. J Arthroplast 32(5):1560–1564CrossRef
24.
Zurück zum Zitat Ledford CK, Chalmers BP, Statz JM, Perry KI, Mabry TM, Hanssen AD, Abdel MP (2017) Primary total knee arthroplasty after solid organ transplant: survivorship and complications. J Arthroplast 32(1):101–105CrossRef Ledford CK, Chalmers BP, Statz JM, Perry KI, Mabry TM, Hanssen AD, Abdel MP (2017) Primary total knee arthroplasty after solid organ transplant: survivorship and complications. J Arthroplast 32(1):101–105CrossRef
25.
Zurück zum Zitat Dukan R, Mal H, Castier Y, Rousseau MA, Boyer P (2021) Safety of shoulder arthroplasty in lung transplant recipients. Arch Orthop Trauma Surg 141(5):795–801CrossRef Dukan R, Mal H, Castier Y, Rousseau MA, Boyer P (2021) Safety of shoulder arthroplasty in lung transplant recipients. Arch Orthop Trauma Surg 141(5):795–801CrossRef
26.
Zurück zum Zitat Ledford CK, Watters TS, Wellman SS, Attarian DE, Bolognesi MP (2014) Outcomes of primary total joint arthroplasty after lung transplantation. J Arthroplast 29(1):11–15CrossRef Ledford CK, Watters TS, Wellman SS, Attarian DE, Bolognesi MP (2014) Outcomes of primary total joint arthroplasty after lung transplantation. J Arthroplast 29(1):11–15CrossRef
27.
Zurück zum Zitat Weller I, Wai EK, Jaglal S, Kreder HJ (2005) The effect of hospital type and surgical delay on mortality after surgery for hip fracture. J Bone Jt Surg Br 87(3):361–366CrossRef Weller I, Wai EK, Jaglal S, Kreder HJ (2005) The effect of hospital type and surgical delay on mortality after surgery for hip fracture. J Bone Jt Surg Br 87(3):361–366CrossRef
28.
Zurück zum Zitat Bottle A, Aylin P (2006) Mortality associated with delay in operation after hip fracture: observational study. BMJ 332(7547):947–951CrossRef Bottle A, Aylin P (2006) Mortality associated with delay in operation after hip fracture: observational study. BMJ 332(7547):947–951CrossRef
29.
Zurück zum Zitat Schemitsch E, Bhandari M (2009) Femoral neck fractures: controversies and evidence. J Orthop Trauma 23(6):385CrossRef Schemitsch E, Bhandari M (2009) Femoral neck fractures: controversies and evidence. J Orthop Trauma 23(6):385CrossRef
30.
Zurück zum Zitat Murphy DK, Randell T, Brennan KL, Probe RA, Brennan ML (2013) Treatment and displacement affect the reoperation rate for femoral neck fracture. Clin Orthop Relat Res 471(8):2691–2702CrossRef Murphy DK, Randell T, Brennan KL, Probe RA, Brennan ML (2013) Treatment and displacement affect the reoperation rate for femoral neck fracture. Clin Orthop Relat Res 471(8):2691–2702CrossRef
31.
Zurück zum Zitat Kim JW, Shon HC, Song SH, Lee YK, Koo KH, Ha YC (2020) Reoperation rate, mortality and ambulatory ability after internal fixation versus hemiarthroplasty for unstable intertrochanteric fractures in elderly patients: a study on Korean Hip Fracture Registry. Arch Orthop Trauma Surg 140(11):1611–1618CrossRef Kim JW, Shon HC, Song SH, Lee YK, Koo KH, Ha YC (2020) Reoperation rate, mortality and ambulatory ability after internal fixation versus hemiarthroplasty for unstable intertrochanteric fractures in elderly patients: a study on Korean Hip Fracture Registry. Arch Orthop Trauma Surg 140(11):1611–1618CrossRef
32.
Zurück zum Zitat Klestil T, Röder C, Stotter C, Winkler B, Nehrer S, Lutz M, Klerings I, Wagner G, Gartlehner G, Nussbaumer-Streit B (2018) Impact of timing of surgery in elderly hip fracture patients: a systematic review and meta-analysis. Sci Rep 8(1):13933CrossRef Klestil T, Röder C, Stotter C, Winkler B, Nehrer S, Lutz M, Klerings I, Wagner G, Gartlehner G, Nussbaumer-Streit B (2018) Impact of timing of surgery in elderly hip fracture patients: a systematic review and meta-analysis. Sci Rep 8(1):13933CrossRef
33.
Zurück zum Zitat Leer-Salvesen S, Engesæter LB, Dybvik E, Furnes O, Kristensen TB, Gjertsen JE (2019) Does time from fracture to surgery affect mortality and intraoperative medical complications for hip fracture patients? An observational study of 73 557 patients reported to the Norwegian Hip Fracture Register. Bone Jt J 101(B(9)):1129–1137CrossRef Leer-Salvesen S, Engesæter LB, Dybvik E, Furnes O, Kristensen TB, Gjertsen JE (2019) Does time from fracture to surgery affect mortality and intraoperative medical complications for hip fracture patients? An observational study of 73 557 patients reported to the Norwegian Hip Fracture Register. Bone Jt J 101(B(9)):1129–1137CrossRef
34.
Zurück zum Zitat Huette P, Abou-Arab O, Djebara AE, Terrasi B, Beyls C, Guinot PG, Havet E, Dupont H, Lorne E, Ntouba A, Mahjoub Y (2020) Risk factors and mortality of patients undergoing hip fracture surgery: a one-year follow-up study. Sci Rep 10(1):9607CrossRef Huette P, Abou-Arab O, Djebara AE, Terrasi B, Beyls C, Guinot PG, Havet E, Dupont H, Lorne E, Ntouba A, Mahjoub Y (2020) Risk factors and mortality of patients undergoing hip fracture surgery: a one-year follow-up study. Sci Rep 10(1):9607CrossRef
Metadaten
Titel
Intertrochanteric fracture fixation in solid organ transplant patients: outcomes and survivorship
verfasst von
Michael J. VanWagner
Steven B. Porter
Aaron C. Spaulding
Glenn G. Shi
Benjamin K. Wilke
Cameron K. Ledford
Publikationsdatum
03.08.2021
Verlag
Springer Berlin Heidelberg
Erschienen in
Archives of Orthopaedic and Trauma Surgery / Ausgabe 10/2022
Print ISSN: 0936-8051
Elektronische ISSN: 1434-3916
DOI
https://doi.org/10.1007/s00402-021-04096-4

Weitere Artikel der Ausgabe 10/2022

Archives of Orthopaedic and Trauma Surgery 10/2022 Zur Ausgabe

Arthropedia

Grundlagenwissen der Arthroskopie und Gelenkchirurgie. Erweitert durch Fallbeispiele, Videos und Abbildungen. 
» Jetzt entdecken

Ein Drittel der jungen Ärztinnen und Ärzte erwägt abzuwandern

07.05.2024 Klinik aktuell Nachrichten

Extreme Arbeitsverdichtung und kaum Supervision: Dr. Andrea Martini, Sprecherin des Bündnisses Junge Ärztinnen und Ärzte (BJÄ) über den Frust des ärztlichen Nachwuchses und die Vorteile des Rucksack-Modells.

Aquatherapie bei Fibromyalgie wirksamer als Trockenübungen

03.05.2024 Fibromyalgiesyndrom Nachrichten

Bewegungs-, Dehnungs- und Entspannungsübungen im Wasser lindern die Beschwerden von Patientinnen mit Fibromyalgie besser als das Üben auf trockenem Land. Das geht aus einer spanisch-brasilianischen Vergleichsstudie hervor.

Endlich: Zi zeigt, mit welchen PVS Praxen zufrieden sind

IT für Ärzte Nachrichten

Darauf haben viele Praxen gewartet: Das Zi hat eine Liste von Praxisverwaltungssystemen veröffentlicht, die von Nutzern positiv bewertet werden. Eine gute Grundlage für wechselwillige Ärztinnen und Psychotherapeuten.

Proximale Humerusfraktur: Auch 100-Jährige operieren?

01.05.2024 DCK 2024 Kongressbericht

Mit dem demographischen Wandel versorgt auch die Chirurgie immer mehr betagte Menschen. Von Entwicklungen wie Fast-Track können auch ältere Menschen profitieren und bei proximaler Humerusfraktur können selbst manche 100-Jährige noch sicher operiert werden.

Update Orthopädie und Unfallchirurgie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.