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Breast Cancer Research

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01.05.2008 | Poster presentation

Investigation of the roles of novel apoptosis-controlling genes in breast cancer

verfasst von: GT Williams, M Mourtada-Maarabouni, MR Pickard, VL Hedge, A Sutherland

Erschienen in: Breast Cancer Research | Sonderheft 2/2008

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Excerpt

Normal mammary epithelial cells, like all other nucleated cells in the body, have the innate capacity to undergo programmed cell death by apoptosis. This process is controlled by external factors such as hormones and growth factors, as well as by cell–cell contacts and recognition of damaged DNA, and plays an essential role in maintaining stable cell numbers. In breast cancer cells, in common with most other cancer cells, the control of apoptosis is defective, so that the rate of cell death falls below that required to maintain a stable cell population size. The analysis of the molecular control of apoptosis is therefore very important in understanding breast cancer development and in producing novel therapies. …

Williams GT, Farzaneh F: The use of gene function to identify the ratelimiting steps controlling cell fate. Cancer Immunol Immunother. 2004, 53: 160-165. 10.1007/s00262-003-0476-6.CrossRefPubMed

Mourtada-Maarabouni M, et al: Functional expression cloning reveals pro-apoptotic role for protein phosphatase 4. Cell Death Differ. 2003, 10: 1016-1024. 10.1038/sj.cdd.4401274.CrossRefPubMed

Mourtada-Maarabouni M, et al: Regulation of apoptosis by Fau revealed by functional expression cloning and antisense expression. Oncogene. 2004, 23: 9419-9426. 10.1038/sj.onc.1208048.CrossRefPubMed

Williams GT, et al: Isolation of genes controlling apoptosis through their effects on cell survival. Gene Ther Mol Biol. 2006, 10: 255-262.PubMedPubMedCentral

Titel: Investigation of the roles of novel apoptosis-controlling genes in breast cancer
verfasst von: GT Williams
M Mourtada-Maarabouni
MR Pickard
VL Hedge
A Sutherland
Publikationsdatum: 01.05.2008
Verlag: BioMed Central
Erschienen in: Breast Cancer Research / Ausgabe Sonderheft 2/2008
Elektronische ISSN: 1465-542X
DOI: https://doi.org/10.1186/bcr1910

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Springer Medizin

Investigation of the roles of novel apoptosis-controlling genes in breast cancer

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