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Cancer Immunology, Immunotherapy

Erschienen in:

01.09.2012 | Symposium-in-writing paper

Involvement of eosinophils in the anti-tumor response

verfasst von: Solène Gatault, Fanny Legrand, Marie Delbeke, Sylvie Loiseau, Monique Capron

Erschienen in: Cancer Immunology, Immunotherapy | Ausgabe 9/2012

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Abstract

Eosinophils have long been associated with allergy and parasitic infections. Today, they are considered as multifunctional leukocytes, which participate both in innate and adaptive immune response though the expression of various receptors and mediators. Although the tumor-associated eosinophilia is observed for a long time in many hematological and solid malignancies, with a generally good prognosis value, there is a lack of knowledge on the different mechanisms involved in this phenomenon. Moreover, the recent discovery in human eosinophils of different receptors and mediators, shared with lymphocytes and involved in anti-tumor defense, suggests that eosinophils can play a role in anti-tumoral immunity. We review in the present paper the current knowledge on epidemiology, recruitment, and mechanisms involved in the response of eosinophils toward tumors.

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Titel: Involvement of eosinophils in the anti-tumor response
verfasst von: Solène Gatault
Fanny Legrand
Marie Delbeke
Sylvie Loiseau
Monique Capron
Publikationsdatum: 01.09.2012
Verlag: Springer-Verlag
Erschienen in: Cancer Immunology, Immunotherapy / Ausgabe 9/2012
Print ISSN: 0340-7004
Elektronische ISSN: 1432-0851
DOI: https://doi.org/10.1007/s00262-012-1288-3

Springer Medizin

Involvement of eosinophils in the anti-tumor response

Abstract

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