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01.12.2010 | Original paper

Iron intake and markers of iron status and risk of Barrett’s esophagus and esophageal adenocarcinoma

verfasst von: Mark G. O’Doherty, Christian C. Abnet, Liam J. Murray, Jayne V. Woodside, Lesley A. Anderson, John D. Brockman, Marie M. Cantwell

Erschienen in: Cancer Causes & Control | Ausgabe 12/2010

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Abstract

Objective

To investigate the association between iron intake and iron status with Barrett’s esophagus (BE) and esophageal adenocarcinoma (EAC).

Methods

A total of 220 BE patients, 224 EAC patients, and 256 frequency-matched controls completed a lifestyle and food frequency questionnaire and provided serum and toenail samples between 2002 and 2005. Using multiple logistic regression, odds ratios (OR) and 95% confidence intervals (95% CI) were calculated within quartiles of intake/status.

Results

Comparing the fourth to the first quartile, ferritin (OR 0.47; 95% CI: 0.23, 0.97) and transferrin saturation (OR 0.41; 95% CI: 0.20, 0.82) were negatively associated with BE; while total iron binding capacity was positively associated per 50 μg/dl increment (OR 1.47; 95% CI: 1.12, 1.92). Comparing the fourth to the first quartile, iron intake (OR 0.50; 95% CI: 0.25, 0.98), non-heme iron intake per 10 mg/day increment (OR 0.29; 95% CI: 0.08, 0.99), and toenail iron (OR 0.40; 95% CI: 0.17, 0.93) were negatively associated with EAC; while heme iron intake was positively associated (OR 3.11 95% CI: 1.46, 6.61).

Principal conclusion

In contrast to the hypothesis that increased iron intakes and higher iron stores are a risk factor for BE and EAC, this study suggests that higher iron intakes and stores may have a protective association with BE and EAC, with the exception of what was found for heme iron intake.

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Bosetti C, Levi F, Ferlay J et al (2008) Trends in oesophageal cancer incidence and mortality in Europe. Int J Cancer 122:1118–1129CrossRefPubMed

Eloubeidi MA, Mason AC, Desmond RA, El-Serag HB (2003) Temporal trends (1973–1997) in survival of patients with esophageal adenocarcinoma in the United States: a glimmer of hope? Am J Gastroenterol 98:1627–1633PubMed

Brown LM, Devesa SS (2002) Epidemiologic trends in esophageal and gastric cancer in the United States. Surg Oncol Clin N Am 11:235–256CrossRefPubMed

Blot WJ, McLaughlin JK (1999) The changing epidemiology of esophageal cancer. Semin Oncol 26:2–8PubMed

di Pietro M, Peters CJ, Fitzgerald RC (2008) Clinical puzzle: Barrett’s oesophagus. Dis Model Mech 1:26–31CrossRefPubMed

Jankowski JA, Harrison RF, Perry I, Balkwill F, Tselepis C (2000) Barrett’s metaplasia. Lancet 356:2079–2085CrossRefPubMed

Shaheen NJ, Crosby MA, Bozymski EM, Sandler RS (2000) Is there publication bias in the reporting of cancer risk in Barrett’s esophagus? Gastroenterology 119:333–338CrossRefPubMed

Henle ES, Luo Y, Gassmann W, Linn S (1996) Oxidative damage to DNA constituents by iron-mediated fenton reactions. The deoxyguanosine family. J Biol Chem 271:21177–21186CrossRefPubMed

Ullen H, Augustsson K, Gustavsson C, Steineck G (1997) Supplementary iron intake and risk of cancer: reversed causality? Cancer Lett 114:215–216CrossRefPubMed

10.

Chen X, Ding YW, Yang G, Bondoc F, Lee MJ, Yang CS (2000) Oxidative damage in an esophageal adenocarcinoma model with rats. Carcinogenesis 21:257–263CrossRefPubMed

11.

Chen X, Yang G, Ding WY, Bondoc F, Curtis SK, Yang CS (1999) An esophagogastroduodenal anastomosis model for esophageal adenocarcinogenesis in rats and enhancement by iron overload. Carcinogenesis 20:1801–1808CrossRefPubMed

12.

Goldstein SR, Yang GY, Chen X, Curtis SK, Yang CS (1998) Studies of iron deposits, inducible nitric oxide synthase and nitrotyrosine in a rat model for esophageal adenocarcinoma. Carcinogenesis 19:1445–1449CrossRefPubMed

13.

Fracanzani AL, Conte D, Fraquelli M et al (2001) Increased cancer risk in a cohort of 230 patients with hereditary hemochromatosis in comparison to matched control patients with non-iron-related chronic liver disease. Hepatology 33:647–651CrossRefPubMed

14.

Elmberg M, Hultcrantz R, Ekbom A et al (2003) Cancer risk in patients with hereditary hemochromatosis and in their first-degree relatives. Gastroenterology 125:1733–1741CrossRefPubMed

15.

Geier D, Hebert B, Potti A (2002) Risk of primary non-hepatocellular malignancies in hereditary hemochromatosis. Anticancer Res 22:3797–3799PubMed

16.

Grant WB (2008) An ecological study of cancer mortality rates including indices for dietary iron and zinc. Anticancer Res 28:1955–1963PubMed

17.

Lee DH, Anderson KE, Folsom AR, Jacobs DR Jr (2005) Heme iron, zinc and upper digestive tract cancer: the Iowa women’s health study. Int J Cancer 117:643–647CrossRefPubMed

18.

Zhang ZF, Kurtz RC, Yu GP et al (1997) Adenocarcinomas of the esophagus and gastric cardia: the role of diet. Nutr Cancer 27:298–309CrossRefPubMed

19.

Wolfgarten E, Rosendahl U, Nowroth T et al (2001) Coincidence of nutritional habits and esophageal cancer in Germany. Onkologie 24:546–551CrossRefPubMed

20.

Corley DA, Kubo A, Levin TR et al (2008) Iron intake and body iron stores as risk factors for Barrett’s esophagus: a community-based study. Am J Gastroenterol 103:2997–3004CrossRefPubMed

21.

Anderson LA, Johnston BT, Watson RG et al (2006) Nonsteroidal anti-inflammatory drugs and the esophageal inflammation-metaplasia-adenocarcinoma sequence. Cancer Res 66:4975–4982CrossRefPubMed

22.

Day N, Oakes S, Luben R et al (1999) EPIC-Norfolk: study design and characteristics of the cohort. European prospective investigation of cancer. Br J Cancer 80:95–103PubMed

23.

Food Standards Agency (2002) McCance and Widdowson’s the composition of foods, 6th summary edn. Royal Society of Chemistry, Cambridge, UK

24.

Balder HF, Vogel J, Jansen MC et al (2006) Heme and chlorophyll intake and risk of colorectal cancer in the Netherlands cohort study. Cancer Epidemiol Biomarkers Prev 15:717–725CrossRefPubMed

25.

Crawley H (1998) Food portion sizes. HMSO, London, UK

26.

Garland M, Morris JS, Rosner BA et al (1993) Toenail trace element levels as biomarkers: reproducibility over a 6-year period. Cancer Epidemiol Biomarkers Prev 2:493–497PubMed

27.

Willett W, Stampfer MJ (1986) Total energy intake: implications for epidemiologic analyzes. Am J Epidemiol 124:17–27PubMed

28.

Pearson TA, Mensah GA, Alexander RW et al (2003) Markers of inflammation and cardiovascular disease: application to clinical and public health practice: a statement for healthcare professionals from the centers for disease control and prevention and the American heart association. Circulation 107:499–511CrossRefPubMed

29.

Hsing AW, McLaughlin JK, Olsen JH, Mellemkjar L, Wacholder S, Fraumeni JF Jr (1995) Cancer risk following primary hemochromatosis: a population-based cohort study in Denmark. Int J Cancer 60:160–162CrossRefPubMed

30.

Lee DH, Anderson KE, Harnack LJ, Folsom AR, Jacobs DR Jr (2004) Heme iron, zinc, alcohol consumption, and colon cancer: Iowa women’s health study. J Natl Cancer Inst 96:403–407CrossRefPubMed

31.

Kabat GC, Miller AB, Jain M, Rohan TE (2008) Dietary iron and heme iron intake and risk of endometrial cancer: a prospective cohort study. Br J Cancer 98:194–198CrossRefPubMed

32.

Kabat GC, Miller AB, Jain M, Rohan TE (2007) Dietary iron and heme iron intake and risk of breast cancer: a prospective cohort study. Cancer Epidemiol Biomarkers Prev 16:1306–1308CrossRefPubMed

33.

Kabat GC, Miller AB, Jain M, Rohan TE (2007) A cohort study of dietary iron and heme iron intake and risk of colorectal cancer in women. Br J Cancer 97:118–122CrossRefPubMed

34.

Anderson LA, Watson RG, Murphy SJ et al (2007) Risk factors for Barrett’s oesophagus and oesophageal adenocarcinoma: results from the FINBAR study. World J Gastroenterol 13:1585–1594PubMed

35.

Brown LM, Swanson CA, Gridley G et al (1995) Adenocarcinoma of the esophagus: role of obesity and diet. J Natl Cancer Inst 87:104–109CrossRefPubMed

36.

Kubo A, Levin TR, Block G et al (2008) Dietary antioxidants, fruits, and vegetables and the risk of Barrett’s esophagus. Am J Gastroenterol 103:1614–1623CrossRefPubMed

37.

Terry P, Lagergren J, Hansen H, Wolk A, Nyren O (2001) Fruit and vegetable consumption in the prevention of oesophageal and cardia cancers. Eur J Cancer Prev 10:365–369CrossRefPubMed

38.

Kubo A, Levin TR, Block G et al (2008) Dietary patterns and the risk of Barrett’s esophagus. Am J Epidemiol 167:839–846CrossRefPubMed

39.

Cross AJ, Leitzmann MF, Gail MH, Hollenbeck AR, Schatzkin A, Sinha R (2007) A prospective study of red and processed meat intake in relation to cancer risk. PLoS Med 4:e325CrossRefPubMed

40.

Gonzalez CA, Jakszyn P, Pera G et al (2006) Meat intake and risk of stomach and esophageal adenocarcinoma within the European prospective investigation into cancer and nutrition (EPIC). J Natl Cancer Inst 98:345–354CrossRefPubMed

41.

Navarro Silvera SA, Mayne ST, Risch H et al (2008) Food group intake and risk of subtypes of esophageal and gastric cancer. Int J Cancer 123:852–860CrossRefPubMed

42.

Lagiou P, Talamini R, Samoli E et al (2001) Diet and upper-aerodigestive tract cancer in Europe: the ARCAGE study. Int J Cancer 124:2671–2676CrossRef

43.

Mayne ST, Risch HA, Dubrow R et al (2001) Nutrient intake and risk of subtypes of esophageal and gastric cancer. Cancer Epidemiol Biomarkers Prev 10:1055–1062PubMed

44.

Chen H, Tucker KL, Graubard BI et al (2002) Nutrient intakes and adenocarcinoma of the esophagus and distal stomach. Nutr Cancer 42:33–40CrossRefPubMed

45.

Hughes R, Cross AJ, Pollock JR, Bingham S (2001) Dose-dependent effect of dietary meat on endogenous colonic N-nitrosation. Carcinogenesis 22:199–202CrossRefPubMed

46.

Lin K, Shen W, Shen Z, Wu Y, Lu S (2002) Dietary exposure and urinary excretion of total N-nitroso compounds, nitrosamino acids and volatile nitrosamine in inhabitants of high- and low-risk areas for esophageal cancer in southern China. Int J Cancer 102:207–211CrossRefPubMed

47.

Schaefer EJ, Augustin JL, Schaefer MM et al (2000) Lack of efficacy of a food-frequency questionnaire in assessing dietary macronutrient intakes in subjects consuming diets of known composition. Am J Clin Nutr 71:746–751PubMed

48.

Beutler E, Felitti V, Ho NJ, Gelbart T (2002) Relationship of body iron stores to levels of serum ferritin, serum iron, unsaturated iron binding capacity and transferrin saturation in patients with iron storage disease. Acta Hemeatol 107:145–149CrossRef

49.

Mei Z, Cogswell ME, Parvanta I et al (2005) Hemoglobin and ferritin are currently the most efficient indicators of population response to iron interventions: an analysis of nine randomized controlled trials. J Nutr 135:1974–1980PubMed

50.

Longnecker MP, Stram DO, Taylor PR et al (1996) Use of selenium concentration in whole blood, serum, toenails, or urine as a surrogate measure of selenium intake. Epidemiology 7:384–390CrossRefPubMed

51.

Fleming DJ, Jacques PF, Dallal GE, Tucker KL, Wilson PW, Wood RJ (1998) Dietary determinants of iron stores in a free-living elderly population: the Framingham heart study. Am J Clin Nutr 67:722–733PubMed

52.

Cook JD, Reddy MB (2001) Effect of ascorbic acid intake on nonheme-iron absorption from a complete diet. Am J Clin Nutr 73:93–98PubMed

53.

Diaz M, Rosado JL, Allen LH, Abrams S, Garcia OP (2003) The efficacy of a local ascorbic acid-rich food in improving iron absorption from Mexican diets: a field study using stable isotopes. Am J Clin Nutr 78:436–440PubMed

54.

Cook JD, Noble NL, Morck TA, Lynch SR, Petersburg SJ (1983) Effect of fiber on nonheme iron absorption. Gastroenterology 85:1354–1358PubMed

55.

Cook JD (1997) Food iron availability: back to the basics. Am J Clin Nutr 67:593–594

56.

Fleming DJ, Tucker KL, Jacques PF, Dallal GE, Wilson PW, Wood RJ (2002) Dietary factors associated with the risk of high iron stores in the elderly Framingham heart study cohort. Am J Clin Nutr 76:1375–1384PubMed

57.

Hurrell RF (1997) Bioavailability of iron. Eur J Clin Nutr 51:S4–S8PubMed

58.

Peneau S, Dauchet L, Vergnaud AC et al (2008) Relationship between iron status and dietary fruit and vegetables based on their vitamin C and fiber content. Am J Clin Nutr 87:1298–1305PubMed

59.

Kubo A, Corley DA (2007) Meta-analysis of antioxidant intake and the risk of esophageal and gastric cardia adenocarcinoma. Am J Gastroenterol 102:2323–2330CrossRefPubMed

60.

Tzonou A, Lipworth L, Garidou A et al (1996) Diet and risk of esophageal cancer by histologic type in a low-risk population. Int J Cancer 68:300–304CrossRefPubMed

61.

Mulholland HG, Cantwell MM, Anderson LA et al (2009) Glycemic index, carbohydrate and fiber intakes and risk of reflux esophagitis, Barrett’s esophagus, and esophageal adenocarcinoma. Cancer Causes Control 20:279–288CrossRefPubMed

62.

McColl KE (2009) Effect of proton pump inhibitors on vitamins and iron. Am J Gastroenterol 104:S5–S9CrossRefPubMed

63.

El-Serag HB (2002) The epidemic of esophageal adenocarcinoma. Gastroenterol Clin North Am 31:421–440 viii

64.

Cook JD (1990) Adaptation in iron metabolism. Am J Clin Nutr 51:301–308PubMed

65.

Islami F, Kamangar F (2008) Helicobacter pylori and esophageal cancer risk: a meta-analysis. Cancer Prev Res (Phila Pa) 1:329–338

66.

Muhsen K, Cohen D (2008) Helicobacter pylori infection and iron stores: a systematic review and meta-analysis. Helicobacter 13:323–340CrossRefPubMed

67.

Hannon EM, Kiely M, Harrington KE, Robson PJ, Strain JJ, Flynn A (2001) The North/South Ireland food consumption survey: mineral intakes in 18–64-year-old adults. Public Health Nutr 4:1081–1088CrossRefPubMed

Titel: Iron intake and markers of iron status and risk of Barrett’s esophagus and esophageal adenocarcinoma
verfasst von: Mark G. O’Doherty
Christian C. Abnet
Liam J. Murray
Jayne V. Woodside
Lesley A. Anderson
John D. Brockman
Marie M. Cantwell
Publikationsdatum: 01.12.2010
Verlag: Springer Netherlands
Erschienen in: Cancer Causes & Control / Ausgabe 12/2010
Print ISSN: 0957-5243
Elektronische ISSN: 1573-7225
DOI: https://doi.org/10.1007/s10552-010-9652-0

Springer Medizin

Iron intake and markers of iron status and risk of Barrett’s esophagus and esophageal adenocarcinoma