Skip to main content
Hauptrubriken
CME Facharzt-Training Webinare Zeitschriften Bücher e.Medpedia Podcast
Service
Jobbörse Info & Hilfe
Fachgebiete
Anästhesiologie Allgemeinmedizin Arbeitsmedizin Augenheilkunde Chirurgie Dermatologie Gynäkologie und Geburtshilfe HNO Innere Medizin Kardiologie Neurologie Onkologie und Hämatologie Orthopädie und Unfallchirurgie Pädiatrie Pathologie Psychiatrie Radiologie Rechtsmedizin Urologie Zahnmedizin
Themen
Klimawandel und Gesundheit Neues aus dem Markt COVID-19 Praxis und Beruf Seltene Erkrankungen GOÄ & EBM Panorama
Sammlungen
Kasuistiken Algorithmen & Infografiken Blickdiagnosen Arthropedia FlapFinder (für Dermatochirurgen) Videos Kongressberichterstattung Medizin für Apothekerinnen und Apotheker Für Ärztinnen und Ärzte in Weiterbildung Für Medizinstudierende
Erweiterte Suche
Anmelden
nach oben
European Journal of Nuclear Medicine and Molecular Imaging
Erschienen in: European Journal of Nuclear Medicine and Molecular Imaging 11/2004

01.11.2004 | Controversies-Pro

Is amyloid plaque imaging the key to monitoring brain pathology of Alzheimer’s disease in vivo?

verfasst von: John Hardy

Erschienen in: European Journal of Nuclear Medicine and Molecular Imaging | Ausgabe 11/2004

Einloggen, um Zugang zu erhalten

Excerpt

It has long been a goal of clinicians working with Alzheimer’s disease to be able to image the pathology of the disease: now that objective is close to being realized, it is worth considering what the limitations of in vivo amyloid imaging are likely to be in respect of both treatment monitoring and diagnosis. …
Literatur
1.
Hardy JA, Higgins GA. Alzheimer’s disease: the amyloid cascade hypothesis. Science 1992;256(5054):184–5.PubMed
2.
Hardy J, Selkoe DJ. Medicine—the amyloid hypothesis of Alzheimer’s disease: progress and problems on the road to therapeutics. Science 2002;297:353–6.CrossRefPubMed
3.
Glenner GG. Amyloid beta protein and the basis for Alzheimer’s disease. Prog Clin Biol Res 1989;317:857–68.PubMed
4.
Klein WL, Stine WB Jr, Teplow DB. Small assemblies of unmodified amyloid beta-protein are the proximate neurotoxin in Alzheimer’s disease. Neurobiol Aging 2004;25(5):569–80.CrossRefPubMed
5.
Klunk WE, Engler H, Nordberg A, Wang Y, Blomqvist G, Holt DP, et al. Imaging brain amyloid in Alzheimer’s disease with Pittsburgh Compound-B. Ann Neurol 2004;55(3):306–19.
6.
Ferenci P. Diagnosis and current therapy of Wilson’s disease. Aliment Pharmacol Ther 2004;19(2):157–65.
7.
Oddo S, Caccamo A, Shepherd JD, Murphy MP, Golde TE, Kayed R, et al. Neuron 2003;39:409–21.CrossRefPubMed
8.
Hutton M, McGowan E. Clearing tau pathology with Aβ immunotherapy: reversible and irreversible stages revealed. Neuron 2003;39.
9.
Mann DM, Yates PO, Marcyniuk B. Alzheimer’s presenile dementia, senile dementia of Alzheimer type and Down’s syndrome in middle age form an age related continuum of pathological changes. Neuropathol Appl Neurobiol 1984;10(3):185–207.PubMed
Metadaten
Titel
Is amyloid plaque imaging the key to monitoring brain pathology of Alzheimer’s disease in vivo?
verfasst von
John Hardy
Publikationsdatum
01.11.2004
Erschienen in
European Journal of Nuclear Medicine and Molecular Imaging / Ausgabe 11/2004
Print ISSN: 1619-7070
Elektronische ISSN: 1619-7089
DOI
https://doi.org/10.1007/s00259-004-1676-9

Weitere Artikel der Ausgabe 11/2004

European Journal of Nuclear Medicine and Molecular Imaging 11/2004 Zur Ausgabe

Editorial

Antibody-based cancer therapies: back to “polyclonals”?

Image of the Month

99mTc-RBC scintigraphy showing portal vein aneurysm

Molecular Imaging

In vitro detection of mdr1 mRNA in murine leukemia cells with 111In-labeled oligonucleotide

Original Article

The sentinel node in cervical cancer: scintigraphy and laparoscopic gamma probe-guided biopsy

Original Article

Treatment of iodine-negative thyroglobulin-positive thyroid cancer: differences in outcome in patients with macrometastases and patients with micrometastases

Original Article

Registration accuracy of 153Gd transmission images of the brain