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European Journal of Nuclear Medicine and Molecular Imaging

Erschienen in:

01.11.2004 | Original Article

Registration accuracy of¹⁵³Gd transmission images of the brain

verfasst von: F. Jacobs, M. Koole, I. Goethals, C. Van de Wiele, H. Ham, R. Dierckx

Erschienen in: European Journal of Nuclear Medicine and Molecular Imaging | Ausgabe 11/2004

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Abstract

Purpose

The aim of the study was to determine the accuracy of non-rigid nine-parameter image registrations based on ¹⁵³Gd transmission computed tomography (TCT) images as compared with those based on ^99mTc-ethyl cysteinate dimer (ECD) images and to assess whether normalised mutual information (NMI) or count difference (CD) should be used.

Methods

TCT and ECD data were acquired in 25 randomly selected patients. Emission images were registered to an ECD template with a CD cost function. The same registration parameters were applied to the transmission images to create a TCT template. All TCT images were registered to the TCT template and the same registration parameters were applied to the ECD images. The procedure was repeated with NMI as cost function. Accuracy of both ECD-based and TCT-based registrations was assessed by comparing the normalisation parameter values and regional activities in the spatially normalised ECD images, using a mixed-model analysis of variance (ANOVA). Scheffé post hoc tests were performed.

Results

No significant differences were found between ECD/CD, ECD/NMI and TCT/CD, suggesting that ECD registration can be done with either CD or NMI, and that TCT registration using CD is equally as accurate as ECD registration. The accuracy of TCT registration with NMI was lower, with discrepancies occurring in the frontal inferior region and the cerebellum. The analysis of normalisation parameters indicated that z-scaling is underestimated and yz-rotation overestimated with TCT/NMI registration.

Conclusion

We conclude that ECD registrations with CD or NMI are as accurate as TCT registrations with CD and that TCT registrations with NMI should be avoided.

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Titel: Registration accuracy of 153Gd transmission images of the brain
verfasst von: F. Jacobs
M. Koole
I. Goethals
C. Van de Wiele
H. Ham
R. Dierckx
Publikationsdatum: 01.11.2004
Verlag: Springer-Verlag
Erschienen in: European Journal of Nuclear Medicine and Molecular Imaging / Ausgabe 11/2004
Print ISSN: 1619-7070
Elektronische ISSN: 1619-7089
DOI: https://doi.org/10.1007/s00259-004-1599-5

Springer Medizin

Abstract

Purpose

Methods

Results

Conclusion

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