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Arthritis Research & Therapy

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01.12.2005 | Commentary

Is closer linkage between systemic lupus erythematosus and anti-double-stranded DNA antibodies a desirable and attainable goal?

verfasst von: Hans C Nossent, Ole Petter Rekvig

Erschienen in: Arthritis Research & Therapy | Ausgabe 2/2005

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Abstract

The anti-double-stranded DNA (anti-dsDNA) antibody test incorporated in the 1982 revised American College of Rheumatology criteria for the classification of systemic lupus erythematosus needs updating to reflect current insights and technical achievements, including allowance for the presence of nonpathogenic anti-dsDNA antibodies. As we need to develop at least some measure of pathogenicity of anti-dsDNA antibodies, we propose that initial anti-dsDNA antibody screening is done by sensitive ELISA and supplemented by more stringent assays. Simultaneously the relevance of anti-dsDNA antibody presence needs to be restricted to clinical manifestations, thought to be caused by anti-dsDNA antibody and within an appropriate time frame.

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Titel: Is closer linkage between systemic lupus erythematosus and anti-double-stranded DNA antibodies a desirable and attainable goal?
verfasst von: Hans C Nossent
Ole Petter Rekvig
Publikationsdatum: 01.12.2005
Verlag: BioMed Central
Erschienen in: Arthritis Research & Therapy / Ausgabe 2/2005
Elektronische ISSN: 1478-6362
DOI: https://doi.org/10.1186/ar1707

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