Erschienen in:
08.01.2019 | Translational Research and Biomarkers
Is FGFR2 a Suitable Target to Treat Scirrhous-Type Gastric Cancer?
verfasst von:
Wataru Yasui
Erschienen in:
Annals of Surgical Oncology
|
Ausgabe 4/2019
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Excerpt
Gastric cancer (GC) is the third most common cause of cancer-related death worldwide, and approximately 1,000,000 people suffer from GC every year.
1 Despite the advances in diagnosis and treatment, prognosis of advanced GC still remains poor. Scirrhous-type GC, composed mainly of diffuse-type GC cells, forms a Borrmann type 4 lesion and shows diffuse infiltration into the gastric wall with abundant fibrous stroma, resulting in thickening and rigidity of the stomach wall. Scirrhous-type GC shows rapid proliferation, progressive invasion, and a high frequency of metastasis to the peritoneum. Increasing rigidity and interstitial pressure may interfere with drug delivery to cancer cells. Crosstalk between cancer cells and fibroblasts/macrophages has been deeply involved in the progression of scirrhous-type GC. Reflecting such characteristics, scirrhous-type GC has the worst prognosis, with a 5-year survival rate of < 15%; therefore, better knowledge of the biological basis of scirrhous-type GC is necessary to improve its treatment. …
