Erschienen in:
12.02.2018 | Letter to the Editor
Is invasion a necessary step for metastases in breast cancer? Narod SA, Sopik V
verfasst von:
Alan B. Hollingsworth, MD
Erschienen in:
Breast Cancer Research and Treatment
|
Ausgabe 3/2018
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Excerpt
The observation that a small percentage of patients diagnosed with DCIS will die of breast cancer years later is not new. Historically, this mortality rate has been in the range of 1–3%, usually attributed to inadequate sectioning of DCIS in the pathology lab, especially in those cases with large areas of high-grade disease wherein the invasive foci were simply not identified. However, once the mammographic era introduced smaller, lower grade DCIS at much higher rates, the phenomenon of mortality with DCIS could still be observed. This sequence was more difficult to explain, but a common assumption was that these patients had invasive recurrences or subsequent invasive primaries that resulted in breast cancer-specific deaths. …