Erschienen in:
27.05.2019 | Brief Report
Isolation and sequence analysis of the complete H gene of canine distemper virus from domestic dogs in Henan Province, China
verfasst von:
Yuxiu Liu, Caihong Liu, Wujie Liu, Hongchao Wu, Hangtian Ding, Yujiao Cao, Norman Spibey, Linxiao Wang, Wenxi He, Liying Hao, Xiangdong Li, Kegong Tian
Erschienen in:
Archives of Virology
|
Ausgabe 8/2019
Einloggen, um Zugang zu erhalten
Abstract
Eighteen canine distemper virus (CDV) isolates were obtained from clinical samples in Henan province, China, between 2012 and 2016. These viruses could not be recognized by 1A4, a monoclonal antibody specific for the H protein of CDV vaccine strains. The complete haemagglutinin (H) genes of all 18 isolates were sequenced, and phylogenetic analysis showed that they segregated into two clusters within the Asia-1 genotype. Moreover, the H genes of four viruses were found to lack a potential N-glycosylation site at position 309, which is the most conserved site within the Asia-1 genotype of CDV, and a novel potential N-glycosylation site (amino acids 517–519) was found in strain HL013, which has not been reported previously. These results will help in achieving a better understanding of the evolution of CDV in China.