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Digestive Diseases and Sciences OnlineFirst articles

Open Access 18.04.2024 | Original Article

Women in Gastroenterology: What Is the Current Situation? Results of an Italian National Survey

Many women grow up dreaming of becoming doctors. Still, after years of studying and training, they have to deal with reality and realize how difficult it is, even today, to be a woman, a doctor, a mother, and a wife at the same time. In some …

verfasst von:
Ludovica Venezia, Nunzia Labarile, Roberta Maselli, Antonio Benedetti, Bruno Annibale, Maria Caterina Parodi, Marco Soncini, Fabiana Zingone

Open Access 18.04.2024 | Original Article

Psychological Care for People with Inflammatory Bowel Diseases: Exploring Consumers’ Perspectives to Inform Future Service Co-design

Inflammatory Bowel Diseases (IBD) such as Crohn’s disease (CD) and ulcerative colitis (UC) can profoundly negatively affect a person’s quality of life [ 1 ]. Symptoms such as diarrhea, urgency, pain and fatigue are chronic and can hinder daily …

verfasst von:
Taryn Lores, Antonina Mikocka-Walus, Jane M. Andrews, Subhadra Evans, Kate D. Lynch, Anna Chur-Hansen

18.04.2024 | Multicenter Seminars: IBD (MUSE: IBD)

A Response-able Diagnosis: Type 2 Autoimmune Pancreatitis in the Setting of Ulcerative Colitis

A previously healthy 36-year-old male was evaluated in the emergency department with two weeks of left-sided abdominal pain and diarrhea. The pain radiated to his back and was associated with poor oral intake and a 25-pound weight loss. Bowel …

verfasst von:
Kevin Kane, Fernando S. Velayos, Jeffrey K. Lee, Sarah Cherny, Kunal Karia

18.04.2024 | Original Article

PPP2CA Inhibition Promotes Ferroptosis Sensitivity Through AMPK/SCD1 Pathway in Colorectal Cancer

Colorectal cancer (CRC) is a very common malignant tumor in the digestive system, ranking 4th (6.1% of cases) and 2nd (9.2% of deaths) in terms of incidence and mortality, respectively [ 1 ]. Although surgery is currently the main choice of …

verfasst von:
Xiaojie Liang, Hui Zhang, Weiwei Shang, Mingming Wang, Jun Li, Yunzhao Zhao, Chao Fang

Open Access 18.04.2024 | Original Article

Real-World Outcomes of Patients Starting Intravenous and Transitioning to Subcutaneous Vedolizumab in Inflammatory Bowel Disease

Inflammatory bowel disease (IBD), comprising Crohn's disease and ulcerative colitis, is a progressive disease characterized by chronic inflammation of the gastrointestinal tract. The disease is associated with impaired quality of life (QoL), loss …

verfasst von:
N. Lamichhane, N. Melas, V. Bergqvist, N.-P. Ekholm, O. Olén, J. F. Ludvigsson, H. Hjortswang, J. Marsal, C. Eriksson, J. Halfvarson, SWIBREG

18.04.2024 | Original Article

Early Versus Standard Initiation of Terlipressin for Acute Kidney Injury in ACLF: A Randomized Controlled Trial (eTerli Study)

Renal failure is a frequent extrahepatic organ failure in patients with acute-on-chronic liver failure (ACLF) and its presence and severity is an independent prognostic marker for mortality [ 1 ]. The current definitions of acute kidney injury …

verfasst von:
Ankur Jindal, Hitesh Singh, Guresh Kumar, Vinod Arora, Manoj Kumar Sharma, Rakhi Maiwall, V. Rajan, Harsh Vardhan Tewathia, Chitranshu Vasishtha, Shiv Kumar Sarin

Open Access 18.04.2024 | Original Article

Patients on Antithrombotic Agents with Small Bowel Bleeding –Yield of Small Bowel Capsule Endoscopy and Subsequent Management

In patients who present with gastrointestinal bleeding (GIB), initial evaluation (including bi-directional endoscopy with esophagogastroduodenoscopy [EGD] and colonoscopy) fails to identify the source of bleeding in 10–20% of cases [ 1 ]. In …

verfasst von:
Sofi Damjanovska, Daniel Karb, Allen Chen, Seunghee Margevicius, Pingfu Fu, Gerard Isenberg

Open Access 15.04.2024 | Original Article

Differences Between Patients with Heartburn Refractory to Vonoprazan and Those Refractory to Proton Pump Inhibitors

Gastroesophageal reflux disease (GERD) is a condition that develops when stomach content reflux causes troublesome symptoms and/or complications [ 1 ]. GERD demonstrated an increasing incidence rate worldwide in recent years [ 2 ]. Various …

verfasst von:
Tomoaki Matsumura, Michiko Sonoda, Kenichiro Okimoto, Hang Viet Dao, Satsuki Takahashi, Naoki Akizue, Ryosuke Horio, Chihiro Goto, Akane Kurosugi, Tatsuya Kaneko, Yuki Ohta, Takashi Taida, Atsuko Kikuchi, Mai Fujie, Jun Kato, Naoya Kato

15.04.2024 | Original Article

UBXN11 Predicts as a Poor Index for Colorectal Cancer and Contributes to the Tumorigenesis by Activating NF-κB Signaling

Digestive tract tumors represent a diverse group of malignancies, including esophageal cancer, gastric cancer, and colorectal cancer, which exert a significant global health burden [ 1 , 2 ]. Among these, colorectal cancer (CRC) emerges as a …

verfasst von:
Xiangbo Chen, Changxin Chen, Rensong He, Yisen Huang, Yubin Wang

Open Access 15.04.2024 | Original Article

CFP/Yit: An Inbred Mouse Strain with Slow Gastrointestinal Transit

Gastrointestinal (GI) transit time (GITT) is defined as the interval between food ingestion and its evacuation. Recently, research has focused on the association of GITT with health and disease, including typical GI diseases as well as certain …

verfasst von:
Gaku Wagai, Masao Togao, Takashi Kurakawa, Haruka Nishizaki, Jun Otsuka, Yuki Ohta-Takada, Akinobu Kurita, Tomo Suzuki, Koji Kawakami

15.04.2024 | Original Article

Engagement in GI Behavioral Health Is Associated with Reduced Portal Messages, Phone Calls, and ED Visits

Chronic digestive conditions, such as inflammatory bowel disease (IBD) and disorders of gut–brain interaction (DGBIs), are recognized as burdensome for patients and expensive for healthcare systems [ 1 – 3 ]. The physical and psychosocial demands …

verfasst von:
Brian J. Arizmendi, Meredith R. Craven, Pablo Martinez-Camblor, Lauren K. Tormey, Jessica K. Salwen-Deremer

14.04.2024 | Original Article

Organizational and Implementation Factors Associated with Cirrhosis Care in the Veterans Health Administration

Cirrhosis, which impacts more than 5 million people in the US, is often under-recognized and suboptimally managed, resulting in high health care costs and preventable deaths [ 1 – 5 ]. However, there are several evidence-based practices that can …

verfasst von:
Heather McCurdy, Anna Nobbe, Dawn Scott, Heather Patton, Timothy R. Morgan, Jasmohan S. Bajaj, Vera Yakovchenko, Monica Merante, Sandra Gibson, Carolyn Lamorte, Gyorgy Baffy, George N. Ioannou, Tamar H. Taddei, Karine Rozenberg-Ben-Dror, Jennifer Anwar, Jason A. Dominitz, Shari S. Rogal

12.04.2024 | Original Article

Triglycerides: A Sensitizer but Not a Trigger for Hypertriglyceridemic Acute Pancreatitis

Acute pancreatitis (AP) is a global disease that is associated with significant morbidity [ 1 ]. Severe acute pancreatitis (SAP) has a mortality rate of up to 30% [ 2 ]. In the USA and European countries, the main etiology was gallstones and …

verfasst von:
Lu Wang, Yutang Ren, Ting Xu, Jinting Geng, Ning Yang, Ruifeng Wang

11.04.2024 | Research

Acute Pancreatitis in Pregnancy: A Propensity Score Matching Analysis and Dynamic Nomogram for Risk Assessment

Acute pancreatitis (AP) is a common acute abdominal condition. However, the AP in some special groups is still lack of cognition, such as acute pancreatitis in pregnancy (APIP). As a rare and serious complication in pregnancy, the incidence of …

verfasst von:
Xiaowei Tang, Yuan Chen, Shu Huang, Jiao Jiang, Bei Luo, Wensen Ren, Xueqin Zhou, Xiaomin Shi, Wei Zhang, Lei Shi, Xiaolin Zhong, Muhan Lü

10.04.2024 | Invited Reviews

Venous Thrombosis in Acute Pancreatitis: What to and Not to Do?

Acute pancreatitis is an acute inflammatory condition of the pancreas that has not only local but systemic effects as well. Venous thrombosis is one such complication which can give rise to thrombosis of the peripheral vasculature in the form of …

verfasst von:
Jayanta Samanta, Jahnvi Dhar, Pankaj Gupta, Rakesh Kochhar

09.04.2024 | Original Article

Red Blood Cell Distribution Width as a Risk Factor for 30/90-Day Mortality in Patients with Gastrointestinal Bleeding: Analysis of the MIMIC-IV Database

Gastrointestinal bleeding (GIB) is a risky, occasionally life-threatening condition that accounts for an essential emergency admission reason. Despite advances in diagnosis and treatment, mortality and morbidity rates continue to be very high [ 1 …

verfasst von:
Yu Chen, Yang Chen, Li Ming, Tan Shiyun

09.04.2024 | Invited Commentary

Prediction of the Severity of Gastrointestinal Bleeding: Reassessing Dominant Wisdom

verfasst von:
Junya Arai, Ryota Niikura, Takao Itoi, Takashi Kawai

09.04.2024 | Original Article

Difference in Cyclic Versus Non-cyclic Symptom Patterns in Patients with the Symptoms of Gastroparesis Undergoing Bioelectric Therapy

Gastroparesis (Gp) is a chronic disease characterized by delay in gastric emptying in the absence of mechanical obstruction. Cyclic vomiting syndrome (CVS) is an idiopathic disorder characterized by recurrent, stereotypical bouts of vomiting with …

verfasst von:
Scott Bills, Amal Shine, Jane Claire Williams, Prateek Mathur, Archana Kedar, Michael Daniels, Thomas L. Abell

09.04.2024 | Original Article

Transpancreatic Sphincterotomy After Double Guidewire Technique Was Noninferior to Primary Transpancreatic Sphincterotomy in Difficult Biliary Cannulation

Endoscopic retrograde cholangiopancreatography(ERCP) is the gold standard for managing cholangiopancreatic diseases [ 1 , 2 ]. Successful common bile duct(CBD) cannulation is a crucial step in performing ERCP. Even among experienced practitioners …

verfasst von:
Shaofei Wang, Bingqing Bai, Sisi Liu, Yuanyuan Fang, Chenyu Zhang, Xinwen Chen, Qiming Huang, Jiren Wang, Jianglong Hong, Yang Li, Zhangwei Xu, Xiaochang Liu, Junjun Bao, Qiao Mei, Rutao Hong

09.04.2024 | Invited Commentary

GES What! Patients with Gastroparesis May Have Cyclical vs. Non-cyclical Symptom Patterns

verfasst von:
Saranya Arumugam, Thangam Venkatesan