Metabolic Brain Disease OnlineFirst articles

03.01.2023 | Original Article

Neuroprotective effects of methyl jasmonate in male Wistar rats exposed to delayed acetic acid-induced ulcerative colitis: involvement of antioxidant status, GFAP, and IBA-1 immunoreactivities

Neurobehavioral deficits have been severally reported as a comorbid outcome in inflammatory bowel diseases (IBDs). This study evaluated neurological changes in the experimental model of IBDs, as well potential protective effects of methyl …

verfasst von:: Tosan P. Omayone, Faizah T. Salami, Oritoke M. Aluko, Jannie N. Nathanniel, Sikirullai O. Jeje, Temitope G. Adedeji, Omamuyovwi M. Ijomone

Open Access 28.12.2022 | Original Article

Deterioration of visual quality and acuity as the first sign of ceroid lipofuscinosis type 3 (CLN3), a rare neurometabolic disease

Ceroid lipofuscinosis type 3 (CLN3) is an autosomal recessive, neurodegenerative metabolic disease. Typical clinical symptoms include progressive visual loss, epilepsy of unknown etiology and dementia. Presence of lipofuscin deposits with typical …

verfasst von:: Joanna Karolina Purzycka-Olewiecka, Katarzyna Hetmańczyk-Sawicka, Tomasz Kmieć, Dominika Szczęśniak, Joanna Trubicka, Maciej Krawczyński, Maciej Pronicki, Agnieszka Ługowska

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15.12.2022 | Correction

Correction to: Methylphenidate disrupts cytoskeletal homeostasis and reduces membrane-associated lipid content in juvenile rat hippocampus

verfasst von:: Felipe Schmitz, Paula Pierozan, Helena Biasibetti-Brendler, Fernanda Silva Ferreira, Fernanda dos Santos Petry, Vera Maria Treis Trindade, Regina Pessoa-Pureur, Angela T. S. Wyse

02.12.2022 | Original Article

8-O-acetyl shanzhiside methylester protects against sleep deprivation-induced cognitive deficits and anxiety-like behaviors by regulating NLRP3 and Nrf2 pathways in mice

Sleep deprivation (SD) is prevalent throughout the world, which has negative effects on cognitive abilities, and causing mood alterations. 8-O-acetyl shanzhiside methylester (8-OaS), a chief component in Lamiophlomis rotata (L. rotata) Kudo …

verfasst von:: Yu-Jiao Li, Xiao-Lu He, Jie-Yu Zhang, Xue-Jiao Liu, Jia-Long Liang, Qing Zhou, Guo-Hua Zhou

01.12.2022 | Original Article

Partial changes in apoptotic pathways in hippocampus and hypothalamus of Cc2d1a heterozygous

Alterations in the apoptosis pathway have been linked to changes in serotonin levels seen in autistic patients. Cc2d1a is a repressor of the HTR1A gene involved in the serotonin pathway. The hippocampus and hypothalamus of Cc2d1a ± mice were …

verfasst von:: Elif Funda Sener, Halime Dana, Reyhan Tahtasakal, Zuhal Hamurcu, Ahsen Guler, Esra Tufan, Zuleyha Doganyigit, Minoo Rassoulzadegan

01.12.2022 | Original Article

CircRNA circ_POSTN promotes the malignancy of glioma by regulating the miR-433-3p/SPARC axis

Glioma is a common tumor in the brain. CircRNA hsa_circ_0030018, also termed as hsa_circPOSTN_001 (circ_POSTN), is reported to exert a promoting influence on the development of glioma. Our study intends to deeply explore its regulation mechanism …

verfasst von:: Xiangting Hua, Chaoyong Zhang, Yongfeng Ba, Shiwei Zhao, Kui Fan, Bin Wang

01.12.2022 | Original Article

PD-L1 is required for estrogen-induced protection against severe EAE in IL-10 deficient mice1

Multiple sclerosis (MS) is a devastating progressive demyelinating disease of the CNS that predominantly affects females (Ben-Nun et al. 2014 ). Women with MS often experience clinical remissions during pregnancy, followed by relapses post-partum …

verfasst von:: Halina Offner, Denesa Lockwood, Roberto Meza-Romero, Arthur A. Vandenbark

16.11.2022 | Original Article

Electroacupuncture promotes remyelination and alleviates cognitive deficit via promoting OPC differentiation in a rat model of subarachnoid hemorrhage

Subarachnoid hemorrhage (SAH) is a devastating cerebral vascular disease which causes neurological deficits including long-term cognitive deficit. Demyelination of white matter is correlated with cognitive deficit in SAH. Electroacupuncture (EA) …

verfasst von:: Yingwen Wang, Xiaomin Yang, Yunchuan Cao, Xiaoguo Li, Rui Xu, Jin Yan, Zongduo Guo, Shanquan Sun, Xiaochuan Sun, Yue Wu

14.11.2022 | Original Article

Impact of miR-200b and miR-495 variants on the risk of large-artery atherosclerosis stroke

Single-nucleotide polymorphisms (SNPs) of microRNAs (miRNAs) may alter miRNA transcription, maturation and target specificity, thus affecting stroke susceptibility. We aimed to investigate whether miR-200b and miR-495 SNPs may be associated with …

verfasst von:: Shanmei Qin, Chong Shen, Wuzhuang Tang, Mengmeng Wang, Ying Lin, Zhaojun Wang, Yunzi Li, Zhizhong Zhang, Xinfeng Liu

09.11.2022 | Correction

Correction to: Circ_0000011 promotes cerebral ischemia/reperfusion injury via miR- 27a-3p-dependent regulation of NRIP1

verfasst von:: Xiaolin Ren, Xinyu Zhou

12.09.2022 | Original Article

The protective effect of inhibiting mitochondrial fission on the juvenile rat brain following PTZ kindling through inhibiting the BCL2L13/LC3 mitophagy pathway

Maintaining the balance of mitochondrial fission and mitochondrial autophagy on seizures is helpful to find a solution to control seizures and reduce brain injuries. The present study is to investigate the protective effect of inhibiting …

verfasst von:: Qiong Fang, Shaojuan Zheng, Qiaobin Chen, Lang Chen, Yating Yang, Ying Wang, Huixia Zhang, Jiafan Chen

27.08.2022 | Original Article

Evaluation of oxidative stress and mitochondrial function in a type II mucopolysaccharidosis cellular model: in vitro effects of genistein and coenzyme Q10

Mucopolysaccharidosis type II (MPS II or Hunter Syndrome) is a lysosomal disease caused by deficient degradation of glycosaminoglycans (GAGs) heparan sulfate and dermatan sulfate due to the deficiency of the enzyme iduronate-2-sulfatase. The main …

verfasst von:: Carlos Eduardo Diaz Jacques, Franciele Fátima Lopes, Edina Poletto, Luisa Natalia Pimentel Vera, Priscila Vianna, Luiza Steffens Reinhardt, Guilherme Baldo, Carmen Regla Vargas

16.06.2022 | Original Article

Evaluation of betulinic acid effects on pain, memory, anxiety, catalepsy, and oxidative stress in animal model of Parkinson’s disease

Parkinson’s disease (PD) is known for motor impairments. Betulinic acid (BA) is a natural compound with antioxidant activity. The present study addresses the question of whether BA affects motor and non-motor dysfunctions and molecular changes in …

verfasst von:: M. Abrishamdar, Yaghoob Farbood, A. Sarkaki, M. Rashno, M. Badavi

07.06.2022 | Original Article

Rapamycin ameliorates brain damage and maintains mitochondrial dynamic balance in diabetic rats subjected to middle cerebral artery occlusion

To investigate the effect of rapamycin on mitochondrial dynamic balance in diabetic rats subjected to cerebral ischemia-reperfusion injury. Male Sprague Dawley (SD) rats (n = 78) were treated with high fat diet combined with streptozotocin …

verfasst von:: Changchun Hei, Yujia Zhou, Chenyang Zhang, Furong Gao, Meiling Cao, Shilin Yuan, Yixin Qin, P. Andy Li, Xiao Yang

25.04.2022 | Original Article

The isothiocyanate sulforaphane prevents mitochondrial impairment and neuroinflammation in the human dopaminergic SH-SY5Y and in the mouse microglial BV2 cells: role for heme oxygenase-1

Sulforaphane (SFN) promotes protective effects in different cell types. Nonetheless, it remains to be clarified by which mechanism SFN exerts benefits in mammalian cells. Mitochondria are a major source of adenosine triphosphate (ATP) and reactive …

verfasst von:: Flávia Bittencourt Brasil, Fhelipe Jolner Souza de Almeida, Matheus Dargesso Luckachaki, Evandro Luiz Dall’Oglio, Marcos Roberto de Oliveira

19.04.2022 | Original Article

Capsaicin induces redox imbalance and ferroptosis through ACSL4/GPx4 signaling pathways in U87-MG and U251 glioblastoma cells

Glioblastoma is one of the deadliest malignant gliomas. Capsaicin is a homovanillic acid derivative that can show anti-cancer effects by regulating various signaling pathways. The aim of this study is to investigate the effects of capsaicin on …

verfasst von:: Ceyhan Hacioglu, Fatih Kar

28.03.2022 | Original Article

Antidepressant activity of phytochemicals of Mangifera indica seeds assisted by integrated computational analysis

Mangifera indica L., also known as mango, is a tropical fruit that belongs to the Anacardiaceae family and is prized for its juiciness, unique flavour, and worldwide popularity. The current study aimed to probe into antidepressant power (ADP) of …

verfasst von:: Uzma Saleem, Shafa Iman, Bashir Ahmad, Muhammad Ajmal Shah, Shabana Bibi, Mohammed Alqarni, Muhammad Saad Khan, Ghulam Mujtaba Shah, Haroon Khan, Reem Hasaballah Alhasani, Norah A. Althobaiti, Aishah E. Albalawi

22.03.2022 | Original Article

The C-glucosyl flavone isoorientin pretreatment attenuates the methylglyoxal-induced mitochondrial dysfunction in the human neuroblastoma SH-SY5Y cells: role for the AMPK-PI3K/Akt/Nrf2/γ-GCL/GSH axis

The reactive dicarbonyl methylglyoxal (MG) behaves as a pro-oxidant agent, causing redox dysfunction and cell death by different mechanisms in mammalian cells. MG is also a mitochondrial toxicant, impairing the oxidative phosphorylation (OXPHOS) …

verfasst von:: Flávia Bittencourt Brasil, Fhelipe Jolner Souza de Almeida, Matheus Dargesso Luckachaki, Evandro Luiz Dall’Oglio, Marcos Roberto de Oliveira

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