The Cerebellum OnlineFirst articles

Open Access 07.05.2024 | RESEARCH

Development and Validation of SCACOMS, a Composite Scale for Assessing Disease Progression and Treatment Effects in Spinocerebellar Ataxia

Spinocerebellar ataxias (SCA) are rare inherited neurodegenerative disorders characterized by a progressive impairment of gait, balance, limb coordination, and speech. There is currently no composite scale that includes multiple aspects of the SCA …

verfasst von:: Gilbert L’Italien, Evan Popoff, Basia Rogula, Lauren Powell, Michele Potashman, Sam Dickson, Patrick O’Keefe, Melissa Beiner, Vlad Coric, Susan Perlman, Jeremy D. Schmahmann, Suzanne Hendrix

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Open Access 07.05.2024 | Research

Content Validity of the Modified Functional Scale for the Assessment and Rating of Ataxia (f-SARA) Instrument in Spinocerebellar Ataxia

The functional Scale for the Assessment and Rating of Ataxia (f-SARA) assesses Gait, Stance, Sitting, and Speech. It was developed as a potentially clinically meaningful measure of spinocerebellar ataxia (SCA) progression for clinical trial use.

verfasst von:: Michele Potashman, Katja Rudell, Ivanna Pavisic, Naomi Suminski, Rinchen Doma, Maggie Heinrich, Linda Abetz-Webb, Melissa Wolfe Beiner, Sheng-Han Kuo, Liana S. Rosenthal, Theresa Zesiwicz, Terry D. Fife, Bart P. van de Warrenburg, Giovanni Ristori, Matthis Synofzik, Susan Perlman, Jeremy D. Schmahmann, Gilbert L’Italien

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03.05.2024 | RESEARCH

Disrupted Rotational Perception During Simultaneous Stimulation of Rotation and Inertia

Two vestibular signals, rotational and inertial cues, converge for the perception of complex motion. However, how vestibular perception is built on neuronal behaviors and decision-making processes, especially during the simultaneous presentation …

verfasst von:: Ju-Young Lee, So-Yeon Yun, Yu-Jin Koo, Jung-Mi Song, Hyo-Jung Kim, Jeong‑Yoon Choi, Ji-Soo Kim

02.05.2024 | Research

Single-Session Cerebellar Transcranial Direct Current Stimulation Improves Postural Stability and Reduces Ataxia Symptoms in Spinocerebellar Ataxia

Spinocerebellar ataxia (SCA) results in balance and coordination impairment, and current treatments have limited efficacy. Recent evidence suggests that combining postural training with cerebellar transcranial direct current stimulation (ctDCS) …

verfasst von:: Rodrigo Brito, João Victor Fabrício, Aurine Araujo, Gabriel Barreto, Adriana Baltar, Kátia Monte-Silva

27.04.2024 | RESEARCH

The Evolution of the Optimization of Cognitive and Social Functions in the Cerebellum and Thereby the Rise of Homo sapiens Through Cumulative Culture

The evolution of the prominent role of the cerebellum in the development of composite tools, and cumulative culture, leading to the rise of Homo sapiens is examined. Following Stout and Hecht's (2017) detailed description of stone-tool making …

verfasst von:: Larry Vandervert, Mario Manto, Michael Adamaszek, Chiara Ferrari, Andrea Ciricugno, Zaira Cattaneo

Open Access 20.04.2024 | RESEARCH

The Role of Verbal Fluency in the Cerebellar Cognitive Affective Syndrome Scale in Friedreich Ataxia

Cerebellar pathology engenders the disturbance of movement that characterizes Friedreich ataxia (FRDA), yet the impact of cerebellar pathology on cognition in FRDA remains unclear. Numerous studies have unequivocally demonstrated the role of the …

verfasst von:: Louise A. Corben, Eliza Blomfield, Geneieve Tai, Hiba Bilal, Ian H. Harding, Nellie Georgiou-Karistianis, Martin B. Delatycki, Adam P. Vogel

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Open Access 19.04.2024 | RESEARCH

The Role of Cognitive Reserve in Protecting Cerebellar Volumes of Older Adults with mild Cognitive Impairment

The present study aims to investigate the relationship between cerebellar volumes and cognitive reserve in individuals with Mild Cognitive Impairment (MCI). A description of proxies of cerebellar cognitive reserve in terms of different volumes …

verfasst von:: Maria Devita, Giulia Debiasi, Mariagiulia Anglani, Chiara Ceolin, Ilaria Mazzonetto, Chiara Begliomini, Simone Cauzzo, Cecilia Raffaelli, Alessandro Lazzarin, Adele Ravelli, Alessandra Bordignon, Marina De Rui, Giuseppe Sergi, Alessandra Bertoldo, Daniela Mapelli, Alessandra Coin

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16.04.2024 | Review

Role of the Cerebellum in the Construction of Functional and Geometrical Spaces

The perceptual and motor systems appear to have a set of movement primitives that exhibit certain geometric and kinematic invariances. Complex patterns and mental representations can be produced by (re)combining some simple motor elements in …

verfasst von:: Eya Torkhani Langlois, Daniel Bennequin, Giovanni de Marco

Open Access 15.04.2024 | RESEARCH

Evaluation of the Patients with the Diagnosis of Pontocerebellar Hypoplasia: A Multicenter National Study

Pontocerebellar hypoplasia (PCH) is a heterogeneous group of neurodegenerative disorders characterized by hypoplasia and degeneration of the cerebellum and pons. We aimed to identify the clinical, laboratory, and imaging findings of the patients …

verfasst von:: Dilek Cavusoglu, Gulten Ozturk, Dilsad Turkdogan, Semra Hiz Kurul, Uluc Yis, Mustafa Komur, Faruk Incecik, Bulent Kara, Turkan Sahin, Olcay Unver, Cengiz Dilber, Gulen Gul Mert, Cagatay Gunay, Gamze Sarikaya Uzan, Ozlem Ersoy, Yavuz Oktay, Serdar Mermer, Gokcen Oz Tuncer, Olcay Gungor, Gul Demet Kaya Ozcora, Ugur Gumus, Ozlem Sezer, Gokhan Ozan Cetin, Fatma Demir, Arzu Yilmaz, Gurkan Gurbuz, Meral Topcu, Haluk Topaloglu, Ahmet Cevdet Ceylan, Serdar Ceylaner, Joseph G. Gleeson, Dilara Fusun Icagasioglu, F. Mujgan Sonmez

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12.04.2024 | RESEARCH

Prenatal Diagnosis of Cerebellar Cortical Dysplasia: Case Report

This was a study of 12 cerebellar cortical dysplasias (CCDs) fetuses, these cases were characterized by a disorder of cerebellar fissures. Historically, CCD diagnosis was primarily performed using postnatal imaging. Unique to this study was the …

verfasst von:: Yan Ding, Zhixuan Chen, Huaxuan Wen, Dandan Luo, Ying Yuan, Shaojun Zhang, Xiaohong Zhong, Shengli Li

06.04.2024 | RESEARCH

Preterm Birth Alters the Regional Development and Structural Covariance of Cerebellum at Term-Equivalent Age

Preterm birth is associated with increased risk for a spectrum of neurodevelopmental disabilities. The cerebellum is implicated in a wide range of cognitive functions extending beyond sensorimotor control and plays an increasingly recognized role …

verfasst von:: Feifei Xu, Yu Wang, Wenjun Wang, Wenjia Liang, Yuchun Tang, Shuwei Liu

01.04.2024 | RESEARCH

Effect of Regional Brain Activity Following Repeat Transcranial Magnetic Stimulation in SCA3: A Secondary Analysis of a Randomized Clinical Trial

Repetitive transcranial magnetic stimulation (rTMS), a noninvasive neuroregulatory technique used to treat neurodegenerative diseases, holds promise for spinocerebellar ataxia type 3 (SCA3) treatment, although its efficacy and mechanisms remain …

verfasst von:: Xia Liu, Lin Zhang, Hao-Lin Xu, Xia-Hua Liu, Arif Sikandar, Meng-Cheng Li, Xiao-Yue Xia, Zi-Qiang Huang, Na-Ping Chen, Yu-Qing Tu, Jian-Ping Hu, Shi-Rui Gan, Qun-Lin Chen, Xin-Yuan Chen, Shi-Zhong Wang, Members of the Organization in South-East China for Cerebellar Ataxia Research (OSCCAR)

26.03.2024 | RESEARCH

Female Cerebellum Seems Sociable; An iTBS Investigation

The cerebellum has been shown to be engaged in tasks other than motor control, including cognitive and affective functions. Prior neuroimaging studies have documented the role of this area in social cognition and despite these findings, no studies …

verfasst von:: Fereshteh Kavandi Ghezeljeh, Reza Kazemi, Reza Rostami, Ahmad Zandbagleh, Sanaz Khomami, Fatemeh Rostam Vandi, Abed L. Hadipour

23.03.2024 | RESEARCH

Prevalence and Diagnostic Journey of Friedreich’s Ataxia in the State of São Paulo, Brazil

Friedreich's Ataxia (FRDA) is the leading cause of ataxia worldwide, but data on epidemiology and diagnostic journey are scarce, particularly in Latin America. Herein we estimated the prevalence of FRDA in the most populous Brazilian state and …

verfasst von:: Daiana Suelen Machado, Celiana Figueiredo Viana, José Luiz Pedroso, Orlando Graziani Povoas Barsottini, Pedro José Tomaselli, Wilson Marques Jr, Thiago J. R. Rezende, Alberto R. M. Martinez, Marcondes Cavalcante França Jr

Open Access 18.03.2024 | Research

Gap Junctions May Have A Computational Function In The Cerebellum: A Hypothesis

In the cerebellum, granule cells make parallel fibre contact on (and excite) Golgi cells and Golgi cells inhibit granule cells, forming an open feedback loop. Parallel fibres excite Golgi cells synaptically, each making a single contact. Golgi …

verfasst von:: Mike Gilbert, Anders Rasmussen

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Open Access 18.03.2024 | RESEARCH

Gravity-Dependent Modulation of Downbeat Nystagmus and Subjective Visual Vertical in the Roll Plane

Downbeat nystagmus (DBN) is the most common form of acquired central vestibular nystagmus. Gravity perception in patients with DBN has previously been investigated by means of subjective visual straight ahead (SVA) and subjective visual vertical …

verfasst von:: Stefan Macher, Daniela Dunkler, Anuscha Theresa Fiehl, Paulus Stefan Rommer, Kirsten Platho-Elwischger, Felix Konstantin Schwarz, Gerald Wiest

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Open Access 18.03.2024 | RESEARCH

Effects of Baclofen on Central Paroxysmal Positional Downbeat Nystagmus

Paroxysmal positional nystagmus frequently occurs in lesions involving the cerebellum, and has been ascribed to disinhibition and enhanced canal signals during positioning due to cerebellar dysfunction. This study aims to elucidate the mechanism …

verfasst von:: So-Yeon Yun, Jong-Hee Lee, Hyo-Jung Kim, Jeong‑Yoon Choi, Ji-Soo Kim

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16.03.2024 | RESEARCH

Quantitative Evaluation of Stance as a Sensitive Biomarker of Postural Ataxia Development in Preclinical SCA1 Mutation Carriers

The aim of this study was to determine the time between the first detection of postural control impairments and the evident manifestation of ataxia in preclinical SCA1 individuals. Twenty five preclinical SCA1 mutation carriers: 13 with estimated …

verfasst von:: Anna Sobanska, Leszek Czerwosz, Anna Sulek, Rafal Rola, Iwona Stepniak, Maria Rakowicz

12.03.2024 | RESEARCH

Neuronal Nitric Oxide Synthase Regulates Cerebellar Parallel Fiber Slow EPSC in Purkinje Neurons by Modulating STIM1-Gated TRPC3-Containing Channels

Responding to burst stimulation of parallel fibers (PFs), cerebellar Purkinje neurons (PNs) generate a convolved synaptic response displaying a fast excitatory postsynaptic current (EPSCFast) followed by a slow EPSC (EPSCSlow). The latter is …

verfasst von:: Le Gui, Vasiliki Tellios, Yun-Yan Xiang, Qingping Feng, Wataru Inoue, Wei-Yang Lu

Open Access 11.03.2024 | RESEARCH

The Effect of Nucleo-Olivary Stimulation on Climbing Fiber EPSPs in Purkinje Cells

Climbing fibers, connecting the inferior olive and Purkinje cells, form the nervous system's strongest neural connection. These fibers activate after critical events like motor errors or anticipation of rewards, leading to bursts of excitatory …

verfasst von:: Josefine Öhman, Elias Sjölin, Maurizio Cundari, Fredrik Johansson, Mike Gilbert, Henk-Jan Boele, Pär Svensson, Anders Rasmussen

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