Pediatric Nephrology OnlineFirst articles

Open Access 25.04.2024 | Original Article

Clinical characteristics and outcomes of immune-complex membranoproliferative glomerulonephritis and C3 glomerulopathy in Japanese children

Membranoproliferative glomerulonephritis (MPGN) is a glomerular injury characterized by pathological findings of mesangial interposition and double contours of the capillary wall [ 1 ]. Historically, MPGN was morphologically classified into three …

verfasst von:: Chika Ueda, Tomoko Horinouchi, Yuta Inoki, Yuta Ichikawa, Yu Tanaka, Hideaki Kitakado, Atsushi Kondo, Nana Sakakibara, China Nagano, Tomohiko Yamamura, Junya Fujimura, Naohiro Kamiyoshi, Shingo Ishimori, Takeshi Ninchoji, Hiroshi Kaito, Yuko Shima, Kazumoto Iijima, Kandai Nozu, Norishige Yoshikawa

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24.04.2024 | Original Article

Copy number variation analysis identifies MIR9-3 and MIR1299 as novel miRNA candidate genes for CAKUT

Congenital anomalies of the kidney and urinary tract (CAKUT) encompass a spectrum of structural and functional abnormalities occurring in approximately 1:500 liveborn children [ 1 ]. In addition to its high incidence, CAKUT is the most frequent …

verfasst von:: Ivan Zivotic, Ivana Kolic, Mirjana Cvetkovic, Brankica Spasojevic-Dimitrijeva, Maja Zivkovic, Aleksandra Stankovic, Ivan Jovanovic

23.04.2024 | Original Article

Mental health and professional outcomes in parents of children with chronic kidney disease

Chronic kidney disease (CKD) has a significant impact on the psychosocial development of a child. Compared with healthy peers, lower quality of life (QoL) and more psychological problems are reported in children with mild to advanced stages of CKD …

verfasst von:: Elke De Bruyne, Sunny Eloot, Lore Willem, Koen Van Hoeck, Johan Vande Walle, Ann Raes, Wim Van Biesen, Liesbet Goubert, Eline Van Hoecke, Evelien Snauwaert

23.04.2024 | Original Article

Kidney outcomes in children with primary focal segmental glomerulosclerosis from a low- and middle- income country

Focal segmental glomerulosclerosis (FSGS) is a distinct histopathological entity of glomerular disorders and a leading cause of kidney failure in children [ 1 ]. In the pediatric population, this glomerular lesion contributes to 7–20% of idiopathic …

verfasst von:: Kolluri Priyanka, Bobbity Deepthi, Sudarsan Krishnasamy, Rajesh Nachiappa Ganesh, Madhileti Sravani, Sriram Krishnamurthy

23.04.2024 | Letter to the Editors

Letter to the editors re Giannattasio et al

verfasst von:: Shimrit Tzvi-Behr

19.04.2024 | Letter to the Editors

Clinical significance of rituximab-associated hypogammaglobulinemia in nephrotic syndrome: to treat or not to treat?

verfasst von:: Eugene Yu-hin Chan

Open Access 18.04.2024 | Review

Is mild dehydration a risk for progression of childhood chronic kidney disease?

Children with chronic kidney disease (CKD) can have an inherent vulnerability to dehydration. Younger children are unable to freely access water, and CKD aetiology and stage can associate with reduced kidney concentrating capacity, which can also …

verfasst von:: Amelia K. Le Page, Evan C. Johnson, Jason H. Greenberg

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18.04.2024 | Original Article

Impact of childhood nephrotic syndrome on obesity and growth: a prospective cohort study

Nephrotic syndrome is one of the most common childhood kidney diseases and is associated with significant disease- and treatment-related morbidity. Incidence of childhood nephrotic syndrome is 2–7/100,000 children per year [ 1 – 3 ]. The …

verfasst von:: Cal H. Robinson, Nowrin Aman, Tonny Banh, Josefina Brooke, Rahul Chanchlani, Vaneet Dhillon, Valerie Langlois, Leo Levin, Christoph Licht, Ashlene McKay, Damien Noone, Alisha Parikh, Rachel Pearl, Seetha Radhakrishnan, Veronique Rowley, Chia Wei Teoh, Jovanka Vasilevska-Ristovska, Rulan S. Parekh

18.04.2024 | Editorial Commentary

Managing anti-factor H antibody-associated hemolytic uremic syndrome: time for consensus

This multicenter study provides information on clinical features, therapy, and outcome of 12 children with mild to moderate anti-FH associated aHUS, with 16% requiring transient dialytic therapy, and 8–25% with extrarenal manifestations at the …

verfasst von:: Priyanka Khandelwal, Arvind Bagga

17.04.2024 | Editorial Commentary

French pediatric nephrologists are in crisis: the consequences of paradoxical injunctions and a plea for action

verfasst von:: Justine Bacchetta, Olivia Boyer, Julien Hogan, François Nobili, Camille Faudeux, Anne Laure Lapeyraque, Emmanuel Fort

17.04.2024 | Original Article

Anti-CFH-associated hemolytic uremic syndrome: do we still need plasma exchange?

Atypical hemolytic uremic syndrome (aHUS) is defined by the association of hemolytic anemia, thrombocytopenia, and kidney impairment and is usually related to a dysregulation of the alternative complement pathway. Unlike typical HUS triggered by a …

verfasst von:: Marion Ferri, Federica Zotta, Roberta Donadelli, Claire Dossier, Charlotte Duneton, Carine El-Sissy, Véronique Fremeau-Bacchi, Thérésa Kwon, Lisa Quadri, Andrea Pasini, Anne-Laure Sellier-Leclerc, Marina Vivarelli, Julien Hogan

15.04.2024 | Clinical Insights

A case of rapid avacopan-induced liver injury in pediatric granulomatosis with polyangiitis

Children with anti-neutrophil cytoplasmic antibody-associated vasculitis benefit immensely from avacopan as it reduces the requirement for steroids. However, descriptions of adverse drug reactions in children are lacking, and the dosage and …

verfasst von:: Tomohiko Nishino, Shinya Tomori, Mei Haruyama, Kazuhiro Takahashi, Masakazu Mimaki

Open Access 15.04.2024 | Original Article

Early diagnosis of solitary functioning kidney: comparing the prognosis of kidney agenesis and multicystic dysplastic kidney

In children, 30–50% of chronic renal failure cases are caused by congenital anomalies of the kidneys and urinary tract (CAKUT) [ 1 , 2 ]. The risk of kidney damage is mainly present in children with bilateral kidney anomalies or solitary …

verfasst von:: Hana Flogelova, Katerina Bouchalova, Oldrich Smakal, Jan Halek, Katerina Langova, Katerina Cizkova

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12.04.2024 | Review

Growth hormone in pediatric chronic kidney disease: more than just height

Recombinant human growth hormone therapy, which was introduced in the 1980s, is now routine for children with advanced chronic kidney disease (CKD) who are exhibiting growth impairment. Growth hormone usage remains variable across different …

verfasst von:: Katie Marie Sullivan, Alison J. Kriegel

12.04.2024 | Educational Review

Do we really need cyclophosphamide for lupus nephritis?

A 14-year-old patient presents with hematuria and proteinuria. Clinical evaluation reveals a positive anti-nuclear antibody titer, positive anti-double stranded DNA antibody and hypocomplementemia. Systemic lupus erythematosus (SLE) is diagnosed …

verfasst von:: Scott E. Wenderfer, Jennifer C. Cooper

12.04.2024 | Clinical Insights

An unusual etiology in an 8-year-old girl with chest pain and elevated troponin-I

Acute post-streptococcal glomerulonephritis (APSGN) is the most common glomerulonephritis of childhood, and clinical presentation can vary widely. This case report presents an atypical manifestation of APSGN in an 8-year-old female patient with …

verfasst von:: Gulsah Ozdemir, Serpil Kaya Celebi, Seyma Kayalı

11.04.2024 | Original Article

Dynamic evolution of kidney function in patients with STEC-hemolytic uremic syndrome followed for more than 15 years: unexpected changes

Shiga toxin-producing Escherichia coli -hemolytic uremic syndrome (STEC-HUS) behaves as a “one shot disease” in which the kidney damage that occurs during the acute stage could lead to renal mass reduction resulting in hyperfiltration and …

verfasst von:: Laura F. Alconcher, Lucas I. Lucarelli, Sabrina Bronfen, Luciana Meni Battaglia, Alejandro Balestracci

11.04.2024 | Review

Genetics of IgA nephrology: risks, mechanisms, and therapeutic targets

IgA nephropathy (IgAN) is a genetically complex multifactorial trait. Over the past decade, population-based genome-wide association studies (GWAS) have identified more than 30 IgAN risk loci, providing novel perspectives on both the epidemiology …

verfasst von:: Shu Qu, Xu-jie Zhou, Hong Zhang

11.04.2024 | Letter to the Editors

Rituximab-induced hypogammaglobulinemia in nephrotic syndrome: what is the true burden?

verfasst von:: Eugene Yu-hin Chan

10.04.2024 | Original Article

Medication fill duration in pediatric hypertension: adherence, blood pressure control, and disparities

Pediatric hypertension is a widespread problem with substantial health impacts. The prevalence in the United States is estimated to be 2–4% in adolescents and as high as 10% in overweight patients [ 1 , 2 ]. Hypertension during childhood and …

verfasst von:: Meghan M. McLaughlin, Conrad D. Gleber, Hongyue Wang, Jill S. Halterman, Marc B. Lande

Springer Medizin