Patent foramen ovale (PFO) is a common cardiac anomaly linked with cryptogenic strokes and migraine, particularly migraine with aura. This study aims to explore the spectrum of headache disorders in PFO patients, focusing on identifying patterns …
verfasst von:
Raluca Ștefania Badea, N. Grecu, A. C. Ribigan, F. Antochi, C. Tiu, B. O. Popescu
Open Access
24.02.2024 | Psychiatry and Preclinical Psychiatric Studies - Review Article
Alternative splicing is a co-transcriptional process that significantly contributes to the molecular landscape of the cell. It plays a multifaceted role in shaping gene transcription, protein diversity, and functional adaptability in response to …
Huntington’s disease (HD) is an autosomal-dominant progressive neurodegenerative disease that manifests with a triad of symptoms including motor dysfunctions, cognitive deficits, and prominent neuropsychiatric symptoms, the most common of which is …
verfasst von:
Kurt A. Jellinger
Open Access
23.01.2024 | Neurology and Preclinical Neurological Studies - Original Article
Fascinatingly, an abundance of recent studies has subscribed to the importance of cytotoxic immune mechanisms that appear to increase the risk/trigger for many progressive neurodegenerative disorders, including Parkinson’s disease (PD) …
Addictions comprises heterogenous psychiatric conditions caused by the complex interaction of genetic, neurobiological, psychological, and environmental factors with a chronic relapsing-remitting pattern. Despite the long-standing efforts of …
verfasst von:
Graziella Madeo, Antonello Bonci
12.01.2024 | Psychiatry and Preclinical Psychiatric Studies - Review Article
There is an emerging view that the increased availability of energy-dense foods in our society is contributing to excessive food consumption which could lead to food addiction-like behavior. Particularly, compulsive eating patterns are predominant …
verfasst von:
Esra Senol, Hasan Mohammad
11.01.2024 | Neurology and Preclinical Neurological Studies - Original Article
Hypomimia is a frequent manifestation in Parkinson's disease (PD) that can affect interpersonal relationships and quality of life. Recent studies have suggested that hypomimia is not only related to motor dysfunction but also to impairment in …
verfasst von:
Jon Rodríguez-Antigüedad, Saül Martínez-Horta, Andrea Horta-Barba, Arnau Puig-Davi, Antonia Campolongo, Frederic Sampedro, Helena Bejr-Kasem, Juan Marín-Lahoz, Javier Pagonabarraga, Jaime Kulisevsky
09.01.2024 | Neurology and Preclinical Neurological Studies - Review Article
Parkinson’s disease is characterized by its distinct pathological features; loss of dopamine neurons in the substantia nigra pars compacta and accumulation of Lewy bodies and Lewy neurites containing modified α-synuclein. Beneficial effects of …
verfasst von:
Makoto Naoi, Wakako Maruyama, Masayo Shamoto-Nagai, Peter Riederer
08.01.2024 | Neurology and Preclinical Neurological Studies - Original Article
The prevalence of Parkinson’s disease (PD) is increasing rapidly worldwide, but there are notable inequalities in its distribution and in the availability of healthcare resources across different world regions. Low- and middle-income countries …
verfasst von:
Roongroj Bhidayasiri
06.01.2024 | Neurology and Preclinical Neurological Studies - Editorial
Adolescence is a period of increased exploration and novelty-seeking, which includes new social behaviors, as well as drug experimentation, often spurred on by peer pressure. This is unfortunate, as the immature state of the adolescent brain makes …
verfasst von:
Radu Gabriel Avramescu, Giovanni Hernandez, Cecilia Flores
Opioid use disorder (OUD) is characterized by a lack of control in opioid use, resulting in psychological distress and deficits in interpersonal and social functioning. OUD is often associated with psychiatric comorbidities that increase the …
The prevention and treatment of addiction (moderate to severe substance use disorder—SUD) have remained challenging because of the dynamic and complex interactions between multiple biological and social determinants that shape SUD. The …
verfasst von:
Rita J. Valentino, Sunila G. Nair, Nora D. Volkow
08.11.2023 | Psychiatry and Preclinical Psychiatric Studies - Review Article
Addiction is a leading cause of disease burden worldwide and remains a challenge in current neuroscience research. Drug-induced lasting changes in gene expression are mediated by transcriptional and epigenetic regulation in the brain and are …
verfasst von:
Leanne M. Holt, Eric J. Nestler
31.10.2023 | Psychiatry and Preclinical Psychiatric Studies - Review Article
The aim of this short commentary is twofold. First, it uncovers and outlines in broad strokes a historical, albeit oft-overlooked, trend toward a growing place for choice and agency in the design of animal models of addiction. Next, it tries to …
verfasst von:
Serge H. Ahmed
29.10.2023 | Neurology and Preclinical Neurological Studies - Review Article
Parkinson’s disease (PD) is a common neurodegenerative disorder, and its association with viral hepatitis has been debated. We performed a meta-analysis to examine the association between PD risk and viral hepatitis. Medline, EMBASE, and the …
verfasst von:
Clyve Yu Leon Yaow, Ashley Shuen Ying Hong, Nicolette Zy-Yin Chong, Ryan Ian Houe Chong, Aaron Shengting Mai, Eng-King Tan
12.10.2023 | Psychiatry and Preclinical Psychiatric Studies - Review Article
Safe and effective therapeutics for psychostimulant use disorders remain elusive. Deep brain stimulation (DBS), which is FDA-approved for other indications, is a promising candidate for treating severe substance use disorders. We examine the …
verfasst von:
Sarah E. Swinford-Jackson, R. Christopher Pierce
01.10.2023 | Psychiatry and Preclinical Psychiatric Studies - Review Article
Clinical and preclinical studies have identified immunosuppressive effects of nicotine, with potential implications for treating nicotine addiction. Here we review how nicotine can regulate microglia, the resident macrophages in the brain, and …
