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Breast Cancer Research
Erschienen in: Breast Cancer Research 5/2009

01.10.2009 | Review

Key signalling nodes in mammary gland development and cancer: Myc

verfasst von: Nancy E Hynes, Tina Stoelzle

Erschienen in: Breast Cancer Research | Ausgabe 5/2009

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Abstract

Myc has been intensely studied since its discovery more than 25 years ago. Insight has been gained into Myc's function in normal physiology, where its role appears to be organ specific, and in cancer where many mechanisms contribute to aberrant Myc expression. Numerous signals and pathways converge on Myc, which in turn acts on a continuously growing number of identified targets, via transcriptional and nontranscriptional mechanisms. This review will concentrate on Myc as a signaling mediator in the mammary gland, discussing its regulation and function during normal development, as well as its activation and roles in breast cancer.
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Metadaten
Titel
Key signalling nodes in mammary gland development and cancer: Myc
verfasst von
Nancy E Hynes
Tina Stoelzle
Publikationsdatum
01.10.2009
Verlag
BioMed Central
Erschienen in
Breast Cancer Research / Ausgabe 5/2009
Elektronische ISSN: 1465-542X
DOI
https://doi.org/10.1186/bcr2406

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