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Erschienen in: Irish Journal of Medical Science (1971 -) 4/2011

01.12.2011 | Original Article

Lack of awareness of risk factors for primary toxoplasmosis in pregnancy

verfasst von: W. Ferguson, P. D. Mayne, M. Cafferkey, K. Butler

Erschienen in: Irish Journal of Medical Science (1971 -) | Ausgabe 4/2011

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Abstract

Background

The overall seroprevalence of toxoplasma antibodies in women of childbearing age in Ireland is 25% [1]. Hence, 75% of women remain susceptible to primary toxoplasma infection during pregnancy, which if transmitted to the foetus can cause ocular, neurological and other sequelae. Toxoplasma exposure during pregnancy can be avoided if there is an awareness of the potential sources of infection, mainly contaminated food, water, soil and cat faeces.

Aims

To determine risk factor exposure in a cohort of women with congenitally infected infants and to assess maternal risk awareness prior to diagnosis of infection.

Methods

Data, prospectively gathered during 2 years of pilot newborn screening for congenital toxoplasmosis in Ireland, was retrospectively analysed. Known risk factors for acquisition of infection were identified. Women were questioned regarding risk awareness and implementation of avoidance measures, if any, during pregnancy.

Results

Fifteen congenitally infected infants were identified by newborn screening. Seventy-three percent of their mothers (11/15) reported lack of knowledge concerning risk factors for toxoplasma infection or its potential threat to the foetus. Ingestion of raw or undercooked meat during pregnancy was the predominant source of toxoplasma cyst exposure identified. Contact with cats was reported in just one case.

Conclusions

Most women were uneducated about the risks posed by Toxoplasma gondii exposure during pregnancy. There is a clear need for better educational programmes regarding primary prevention of congenital toxoplasmosis if neonatal infection is to be avoided.
Literatur
1.
Zurück zum Zitat Ferguson W, Mayne PD, Lennon B, Butler KM, Cafferkey M (2008) Susceptibility of pregnant women to toxoplasma infection-potential benefits for newborn screening. IMJ 101(7):220–221PubMed Ferguson W, Mayne PD, Lennon B, Butler KM, Cafferkey M (2008) Susceptibility of pregnant women to toxoplasma infection-potential benefits for newborn screening. IMJ 101(7):220–221PubMed
2.
Zurück zum Zitat Ajzenberg D, Cogne N, Paris L et al (2002) Genotype of 86 Toxoplasma gondii isolates associated with human congenital toxoplasmosis and correlation with clinical findings. J Infect Dis 186(5):684–689PubMedCrossRef Ajzenberg D, Cogne N, Paris L et al (2002) Genotype of 86 Toxoplasma gondii isolates associated with human congenital toxoplasmosis and correlation with clinical findings. J Infect Dis 186(5):684–689PubMedCrossRef
3.
Zurück zum Zitat Peyron F, Lobry JR, Musset K et al (2006) Serotyping of Toxoplasma gondii in chronically infected pregnant women: predominance of type II in Europe and types I and III in South America. Microbes Infect 8(9–10):2333–2340PubMedCrossRef Peyron F, Lobry JR, Musset K et al (2006) Serotyping of Toxoplasma gondii in chronically infected pregnant women: predominance of type II in Europe and types I and III in South America. Microbes Infect 8(9–10):2333–2340PubMedCrossRef
4.
Zurück zum Zitat Leal FE, Cavazzana CL, de Andrade HF Jr, Galisteo AJ Jr, de Mendonca JS, Kallas EG (2007) Toxoplasma gondii pneumonia in immunocompetent subjects: case report and review. Clin Infect Dis 44(6):e62–e66PubMedCrossRef Leal FE, Cavazzana CL, de Andrade HF Jr, Galisteo AJ Jr, de Mendonca JS, Kallas EG (2007) Toxoplasma gondii pneumonia in immunocompetent subjects: case report and review. Clin Infect Dis 44(6):e62–e66PubMedCrossRef
5.
Zurück zum Zitat Holland GN (2003) Ocular toxoplasmosis: a global reassessment. Part 1: Epidemiology and course of disease. Am J Ophthalmol 136(6):973–988PubMedCrossRef Holland GN (2003) Ocular toxoplasmosis: a global reassessment. Part 1: Epidemiology and course of disease. Am J Ophthalmol 136(6):973–988PubMedCrossRef
6.
Zurück zum Zitat Cook AJ, Gilbert RE, Buffolano W et al (2000) Sources of toxoplasma infection in pregnant women: European multicentre case-control study. European Research Network on Congenital Toxoplasmosis. BMJ 321(7254):142–147PubMedCrossRef Cook AJ, Gilbert RE, Buffolano W et al (2000) Sources of toxoplasma infection in pregnant women: European multicentre case-control study. European Research Network on Congenital Toxoplasmosis. BMJ 321(7254):142–147PubMedCrossRef
7.
Zurück zum Zitat Lopez A, Dietz VJ, Wilson M, Navin TR, Jones JL (2000) Preventing congenital toxoplasmosis. MMWR Recomm Rep 49(RR-2):59–68PubMed Lopez A, Dietz VJ, Wilson M, Navin TR, Jones JL (2000) Preventing congenital toxoplasmosis. MMWR Recomm Rep 49(RR-2):59–68PubMed
8.
Zurück zum Zitat McLeod R, Boyer K, Karrison T et al (2006) Outcome of treatment for congenital toxoplasmosis, 1981–2004: the National Collaborative Chicago-Based, Congenital Toxoplasmosis Study. Clin Infect Dis 42:1383–1394PubMedCrossRef McLeod R, Boyer K, Karrison T et al (2006) Outcome of treatment for congenital toxoplasmosis, 1981–2004: the National Collaborative Chicago-Based, Congenital Toxoplasmosis Study. Clin Infect Dis 42:1383–1394PubMedCrossRef
9.
Zurück zum Zitat Havelaar AH, Kemmeren JM, Kortbeek LM (2007) Disease burden of congenital toxoplasmosis. Clin Infect Dis 44:1467–1474PubMedCrossRef Havelaar AH, Kemmeren JM, Kortbeek LM (2007) Disease burden of congenital toxoplasmosis. Clin Infect Dis 44:1467–1474PubMedCrossRef
10.
Zurück zum Zitat Wallon M, Kodjikian L, Binquet C et al (2004) Long-term ocular prognosis in 327 children with congenital toxoplasmosis. Paediatrics 113(6):1567–1572CrossRef Wallon M, Kodjikian L, Binquet C et al (2004) Long-term ocular prognosis in 327 children with congenital toxoplasmosis. Paediatrics 113(6):1567–1572CrossRef
11.
Zurück zum Zitat Gilbert RE, Freeman K, Lago EG et al (2008) Ocular sequelae of congenital toxoplasmosis in Brazil compared with Europe. PLoS Negl Trop Dis 2(8):e277PubMedCrossRef Gilbert RE, Freeman K, Lago EG et al (2008) Ocular sequelae of congenital toxoplasmosis in Brazil compared with Europe. PLoS Negl Trop Dis 2(8):e277PubMedCrossRef
12.
Zurück zum Zitat Pinon JM, Dumon H, Chemla C et al (2001) Strategy for diagnosis of congenital toxoplasmosis: evaluation of methods comparing mothers and newborns and standard methods for postnatal detection of immunoglobulin G, M, and A antibodies. J Clin Microbiol 39(6):2267–2271PubMedCrossRef Pinon JM, Dumon H, Chemla C et al (2001) Strategy for diagnosis of congenital toxoplasmosis: evaluation of methods comparing mothers and newborns and standard methods for postnatal detection of immunoglobulin G, M, and A antibodies. J Clin Microbiol 39(6):2267–2271PubMedCrossRef
14.
Zurück zum Zitat Breugelmans M, Naessens A, Foulon W (2004) Prevention of toxoplasmosis during pregnancy-an epidemiologic survey over 22 consecutive years. J Perinat Med 32(3):211–214PubMedCrossRef Breugelmans M, Naessens A, Foulon W (2004) Prevention of toxoplasmosis during pregnancy-an epidemiologic survey over 22 consecutive years. J Perinat Med 32(3):211–214PubMedCrossRef
15.
Zurück zum Zitat Montoya JG, Remington JS (2008) Management of Toxoplasma gondii infection during pregnancy. Clin Infect Dis 47(4):554–566PubMedCrossRef Montoya JG, Remington JS (2008) Management of Toxoplasma gondii infection during pregnancy. Clin Infect Dis 47(4):554–566PubMedCrossRef
17.
Zurück zum Zitat Jones JL, Kruszon-Moran D, Wilson M, Mc Quillan G, Navin T, Mc Auley JB (2001) Toxoplasma gondii infection in the United States: seroprevalence and risk factors. Am J Epidemiol 154(4):357–365PubMedCrossRef Jones JL, Kruszon-Moran D, Wilson M, Mc Quillan G, Navin T, Mc Auley JB (2001) Toxoplasma gondii infection in the United States: seroprevalence and risk factors. Am J Epidemiol 154(4):357–365PubMedCrossRef
18.
Zurück zum Zitat Gollub EL, Leroy V, Gilbert R, Chene G, Wallon M (2008) European Toxoprevention Study Group (EUROTOXO). Effectiveness of health education on Toxoplasma related knowledge, behaviour, and risk of seroconversion in pregnancy. Eur J Obstet Gynecol Reprod Biol 136(2):137–145PubMedCrossRef Gollub EL, Leroy V, Gilbert R, Chene G, Wallon M (2008) European Toxoprevention Study Group (EUROTOXO). Effectiveness of health education on Toxoplasma related knowledge, behaviour, and risk of seroconversion in pregnancy. Eur J Obstet Gynecol Reprod Biol 136(2):137–145PubMedCrossRef
19.
Zurück zum Zitat Jones JL, Krueger A, Schulkin J, Schantz PM (2010) Toxoplasmosis prevention and testing in pregnancy, survey of obstetrician-gynaecologists. Zoonoses Public Health 57(1):27–33PubMedCrossRef Jones JL, Krueger A, Schulkin J, Schantz PM (2010) Toxoplasmosis prevention and testing in pregnancy, survey of obstetrician-gynaecologists. Zoonoses Public Health 57(1):27–33PubMedCrossRef
20.
Zurück zum Zitat The SYROCOT (Systematic Review on Congenital Toxoplasmosis) study group, Thiebaut R, Leproust S, Chene G, Gilbert RE (2007) Effectiveness of prenatal treatment for congenital toxoplasmosis: a meta-analysis of individual patients’ data. Lancet 369(9556):115–122 The SYROCOT (Systematic Review on Congenital Toxoplasmosis) study group, Thiebaut R, Leproust S, Chene G, Gilbert RE (2007) Effectiveness of prenatal treatment for congenital toxoplasmosis: a meta-analysis of individual patients’ data. Lancet 369(9556):115–122
Metadaten
Titel
Lack of awareness of risk factors for primary toxoplasmosis in pregnancy
verfasst von
W. Ferguson
P. D. Mayne
M. Cafferkey
K. Butler
Publikationsdatum
01.12.2011
Verlag
Springer-Verlag
Erschienen in
Irish Journal of Medical Science (1971 -) / Ausgabe 4/2011
Print ISSN: 0021-1265
Elektronische ISSN: 1863-4362
DOI
https://doi.org/10.1007/s11845-011-0723-3

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