Background
Methods
Study participants
Participant information
Cytokine analysis
Quality control
Statistical analysis
Results
Epidemiologic results
Characteristic | No Adenoma N = 97 | Any Adenoma N = 97 | p-value |
---|---|---|---|
Center | |||
San Antonio, TX | 26 (50.0) | 26 (50.0) | 1.00 |
San Luis Valley, CO | 20 (50.0) | 20 (50.0) | |
Oakland, CA | 34 (50.0) | 34 (50.0) | |
Los Angeles, CA | 17 (50.0) | 17 (50.0) | |
Sex | |||
Male | 33 (39.8) | 50 (60.2) | 0.01 |
Female | 64 (57.7) | 47 (42.3) | |
Age | |||
<60 | 36 (62.1) | 22 (37.9) | <0.01 |
60-69 | 42 (53.9) | 36 (46.2) | |
70+ | 19 (32.8) | 39 (67.2) | |
Race/Ethnicity | |||
Non-Hispanic White | 32 (43.2) | 42 (56.8) | 0.14 |
Black | 35 (60.3) | 23 (39.7) | |
Hispanic | 30 (48.4) | 32 (51.6) | |
Glucose tolerance at 1992-94 | |||
Normoglucose | 54 (49.5) | 55 (50.5) | 0.68 |
Impaired glucose tolerance | 20 (57.1) | 15 (42.9) | |
Type II diabetes mellitus | 23 (47.9) | 25 (52.1) | |
BMI (kg/m2) at 2002-2004 | |||
Normal (<25kg/m2) | 54 (50.0) | 54 (50.0) | 1.00 |
Overweight (25-29.9 kg/m2) | 19 (50.0) | 19 (50.0) | |
Obese (30 + kg/m2) | 24 (50.0) | 24 (50.0) | |
Smoking at 2002-2004 | |||
Never | 51 (53.7) | 44 (46.3) | 0.32 |
Ever | 46 (46.7) | 53 (53.5) | |
Self reported previous screening | |||
None | 34 (54.8) | 28 (45.2) | <0.01 |
Yes, without polyp | 56 (54.9) | 46 (45.1) | |
Yes, with polyp | 7 (23.3) | 23 (76.7) | |
NSAID use | |||
None or Don’t Know | 33 (45.2) | 40 (54.8) | 0.30 |
Yes | 64 (52.9) | 57 (47.1) |
Normal biological relationships are observed in serum cytokines used for analysis
Adenomas are not associated with altered serum cytokine levels
Cytokines | Adenoma prevalence n/N (%) | Crude OR (95% CI) | Adjusted OR (95% CI) |
---|---|---|---|
GM-CSF
| |||
L
| 67/124 (54.0) | 1.00 | 1.00 |
M
| 17/37 (46.0) | 0.72 (0.35 1.51) | 0.83 (0.38 1.82) |
H
| 13/33 (39.4) | 0.55 (0.25 1.21) | 0.70 (0.30 1.62) |
p for trend
| 0.38 | ||
Interferon gamma
| |||
L
| 37/77 (48.1) | 1.00 | 1.00 |
M
| 42/71 (59.2) | 1.57 (0.82 3.00) | 1.35 (0.67 2.72) |
H
| 18/46 (39.1) | 0.69 (0.33 1.46) | 0.77 (0.35 1.69) |
p for trend
| 0.67 | ||
IL-10
| |||
L
| 55/112 (49.1) | 1.00 | 1.00 |
M
| 18/38 (47.4) | 0.93 (0.45 1.95) | 0.91 (0.41 2.00) |
H
| 24/44 (54.6) | 1.24 (0.62 2.50) | 1.45 (0.69 3.08) |
p for trend
| 0.40 | ||
IL-12p70
| |||
L
| 50/103 (48.5) | 1.00 | 1.00 |
M
| 35/57 (61.4) | 1.69 (0.87 3.26) | 1.86 (0.92 3.76) |
H
| 12/34 (35.3) | 0.58 (0.26 1.29) | 0.59 (0.25 1.42) |
p for trend
| 0.68 | ||
IL-17A
| |||
L
| 82/152 (54.0) | 1.00 | 1.00 |
M
| 5/19 (26.3) | 0.30 (0.10 0.89) | 0.42 (0.14 1.30) |
H
| 10.23 (43.5) | 0.66 (0.27 1.59) | 0.83 (0.33 2.13) |
p for trend
| 0.40 | ||
IL-18
| |||
L
| 67/127 (52.8) | 1.00 | 1.00 |
M
| 12/31 (38.7) | 0.57 (0.25 1.26) | 0.81 (0.34 1.96) |
H
| 18/36 (50.0) | 0.90 (0.43 1.88) | 1.09 (0.50 2.41) |
p for trend
| 0.93 | ||
IL-2
| |||
L
| 37/132 (50.8) | 1.00 | 1.00 |
M
| 15/31 (48.4) | 0.91 (0.42 1.99) | 1.25 (0.53 2.96) |
H
| 15/31 (48.4) | 0.91 (0.42 1.99) | 1.14 (0.49 2.62) |
p for trend
| 0.67 | ||
IL-4
| |||
L
| 56/117 (47.9) | 1.00 | 1.00 |
M
| 24/42 (57.1) | 1.45 (0.71 2.96) | 1.83 (0.84 3.98) |
H
| 17/35 (48.6) | 1.03 (0.48 2.19) | 1.33 (0.59 3.02) |
p for trend
| 0.29 | ||
IL-6
| |||
L
| 53/117 (45.3) | 1.00 | 1.00 |
M
| 29/46 (63.0) | 2.06 (1.02 4.15) | 2.57 (1.19 5.54) |
H
| 15/31 (48.4) | 1.13 (0.51 2.50) | 1.35 (0.58 3.19) |
p for trend
| 0.17 | ||
IL-7
| |||
L
| 40/73 (54.8) | 1.00 | 1.00 |
M
| 28/60 (46.7) | 0.72 (0.36-1.43) | 0.59 (0.28-1.24) |
H
| 29/61 (47.5) | 0.75 (0.38-1.48) | 0.60 |
p for trend
| |||
MIP-1β
| |||
L
| 22/53 (41.5 | 1.00 | 1.00 |
M
| 53/87 (60.9) | 2.20 (1.10-4.40 | 2.69 (1.25-5.80) |
H
| 22/54 (4.7) | 0.97 (0.45-2.09) | 1.25 (0.54-2.91) |
p for trend
| 0.65 | ||
RANTES
| |||
L
| 46/79 (58.2) | 1.00 | 1.00 |
M
| 32/64 (50.0) | 0.72 (0.37-1.39) | 0.66 (0.33-1.35) |
H
| 19/51 (37.3) | 0.43 (0.21-0.88) | 0.46 (0.21-0.99) |
p for trend
| 0.04 | ||
VEGF
| |||
L
| 13/19 (68.4) | 1.00 | 1.00 |
M
| 40/86 (46.5) | 0.40 (0.14-1.15) | 0.42 (0.14-1.28) |
H
| 44/89 (49.4) | 0.45 (0.46-1.29) | 0.62 (0.20-1.88) |
p for trend
| 0.97 | ||
TNFα
| |||
L
| 31/64 (48.9) | 1.00 | 1.00 |
M
| 37/68 (54.4) | 1.27 (0.64-2.51) | 1.27 (0.64-2.52) |
H
| 29/62 (46.8) | 0.93 (0.46-1.88) | 1.14 (0.55-2.35) |
p for trend
| 0.54 |