BMC Cancer

Liposome encapsulated zoledronate favours M1-like behaviour in murine macrophages cultured with soluble factors from breast cancer cells

• Open Access
• Research article

Sofia Sousa, Seppo Auriola, Jukka Mönkkönen, Jorma Määttä

Clinicopathological significance of nuclear factor (erythroid-2)-related factor 2 (Nrf2) expression in gastric cancer

• Open Access
• Research article

Yota Kawasaki, Sumiya Ishigami, Takaaki Arigami, Yoshikazu Uenosono, Shigehiro Yanagita, Yasuto Uchikado, Yoshiaki Kita, Yuka Nishizono, Hiroshi Okumura, Akihiro Nakajo, Yuko Kijima, Kosei Maemura, Shoji Natsugoe

Expression and clinical significance of c-Met in advanced esophageal squamous cell carcinoma

• Open Access
• Research article

Yingying Xu, Zhi Peng, Zhongwu Li, Ming Lu, Jing Gao, Yilin Li, Yanyan Li, Lin Shen

Computational cancer biology: education is a natural key to many locks

• Open Access
• DEBATE

Frank Emmert-Streib, Shu-Dong Zhang, Peter Hamilton

Molecular characteristics of endometrial cancer coexisting with peritoneal malignant mesothelioma in Li-Fraumeni-like syndrome

• Open Access
• Case report

Angel Chao, Chyong-Huey Lai, Yun-Shien Lee, Shir-Hwa Ueng, Chiao-Yun Lin, Tzu-Hao Wang

Androgen-regulation of the protein tyrosine phosphatase PTPRR activates ERK1/2 signalling in prostate cancer cells

• Open Access
• Research article

Jennifer Munkley, Nicholas P Lafferty, Gabriela Kalna, Craig N Robson, Hing Y Leung, Prabhakar Rajan, David J Elliott

Role of baseline echocardiography prior to initiation of anthracycline-based chemotherapy in breast cancer patients

• Open Access
• Research article

Alain Mina, Hind Rafei, Maya Khalil, Yasmine Hassoun, Zeina Nasser, Arafat Tfayli

Clinical observations on chemotherapy curable malignancies: unique genetic events, frozen development and enduring apoptotic potential

• Open Access
• Debate

Philip Savage

Microfluidic model of ductal carcinoma in situ with 3D, organotypic structure

• Open Access
• Technical advance

Lauren L Bischel, David J Beebe, Kyung E Sung

STK33 overexpression in hypopharyngeal squamous cell carcinoma: possible role in tumorigenesis

• Open Access
• Research article

Lingyan Huang, Chen Chen, Guodong Zhang, Yuanrong Ju, Jianzhong Zhang, Haibo Wang, Jianfeng Li

Histopathological features predict metastatic potential in locally advanced colon carcinomas

• Open Access
• Research article

Caren Jayasinghe, Nektaria Simiantonaki, Charles James Kirkpatrick

Prognostic factors and treatment outcomes in patients with Small Bowel Adenocarcinoma (SBA): The Royal Marsden Hospital (RMH) experience

• Open Access
• Research article

Khurum Khan, Clare Peckitt, Francesco Sclafani, David Watkins, Sheela Rao, Naureen Starling, Vikram Jain, Sachin Trivedi, Susannah Stanway, David Cunningham, Ian Chau

Ewing sarcoma of the liver with multilocular cystic mass formation: a case report

• Open Access
• Case report

Yukinori Ozaki, Yuji Miura, Shigehiro Koganemaru, Koichi Suyama, Naoko Inoshita, Takeshi Fujii, Masaji Hashimoto, Tetsuo Tamura, Kazuo Takeuchi, Toshimi Takano

Nitric oxide donors increase PVR/CD155 DNAM-1 ligand expression in multiple myeloma cells: role of DNA damage response activation

• Open Access
• Research article

Cinzia Fionda, Maria Pia Abruzzese, Alessandra Zingoni, Alessandra Soriani, Biancamaria Ricci, Rosa Molfetta, Rossella Paolini, Angela Santoni, Marco Cippitelli

Downregulation of EphA5 by promoter methylation in human prostate cancer

• Open Access
• Research article

Shibao Li, Yingfeng Zhu, Chunguang Ma, Zhenhua Qiu, Xinju Zhang, Zhihua Kang, Zhiyuan Wu, Hua Wang, Xiao Xu, Hu Zhang, Guoqiang Ren, Jianmin Tang, Xiangyu Li, Ming Guan

The novel histone deacetylase inhibitor, N-hydroxy-7-(2-naphthylthio) hepatonomide, exhibits potent antitumor activity due to cytochrome-c-release-mediated apoptosis in renal cell carcinoma cells

• Open Access
• Research article

Ki Cheong Park, Jun Hyeok Heo, Jeong Yong Jeon, Hye Ji Choi, A Ra Jo, Seung Won Kim, Ho Jeong Kwon, Sung Joon Hong, Kyung Seok Han

Methylation and expression of the tumour suppressor, PRDM5, in colorectal cancer and polyp subgroups

• Open Access
• Research article

Catherine E Bond, Mark L Bettington, Sally-Ann Pearson, Diane M McKeone, Barbara A Leggett, Vicki LJ Whitehall

Antihormonal agents as a strategy to improve the effect of chemo-radiation in cervical cancer: in vitro and in vivo study

• Open Access
• Research article

Mariana Segovia-Mendoza, Rafael Jurado, Roser Mir, Luis A Medina, Heriberto Prado-Garcia, Patricia Garcia-Lopez

TOX3 is expressed in mammary ER+ epithelial cells and regulates ER target genes in luminal breast cancer

• Open Access
• Research article

Akop Seksenyan, Asha Kadavallore, Ann E Walts, Brian de la Torre, Dror Berel, Samuel P Strom, Parinaz Aliahmad, Vincent A Funari, Jonathan Kaye

Bilateral Diffuse Uveal Melanocytic Proliferation (BDUMP) associated with B-cell lymphoma: report of a rare case

• Open Access
• Case report

Maria Pefkianaki, Rupesh Agrawal, Parul Desai, Carlos Pavesio, Mandeep S Sagoo

Cell fusion between gastric epithelial cells and mesenchymal stem cells results in epithelial-to-mesenchymal transition and malignant transformation

• Open Access
• Research article

Xianghui He, Baosong Li, Yang Shao, Na Zhao, Yiling Hsu, Zhixiang Zhang, Liwei Zhu

Caveolin-1 accumulation in the tongue cancer tumor microenvironment is significantly associated with poor prognosis: an in-vivo and in-vitro study

• Open Access
• Research article

Marilena Vered, Meri Lehtonen, Lari Hotakainen, Emma Pirilä, Susanna Teppo, Pia Nyberg, Raija Sormunen, Ayelet Zlotogorski-Hurvitz, Tuula Salo, Dan Dayan

Development of a semi-conductor sequencing-based panel for genotyping of colon and lung cancer by the Onconetwork consortium

• Open Access
• Research article

Bastiaan BJ Tops, Nicola Normanno, Henriette Kurth, Eliana Amato, Andrea Mafficini, Nora Rieber, Delphine Le Corre, Anna Maria Rachiglio, Anne Reiman, Orla Sheils, Christoph Noppen, Ludovic Lacroix, Ian A Cree, Aldo Scarpa, Marjolijn JL Ligtenberg, Pierre Laurent-Puig

Prognostic survival model for people diagnosed with invasive cutaneous melanoma

• Open Access
• Research article

Peter D Baade, Patrick Royston, Philipa H Youl, Martin A Weinstock, Alan Geller, Joanne F Aitken

Weight and weight change following breast cancer: evidence from a prospective, population-based, breast cancer cohort study

• Open Access
• Research article

Dimitrios Vagenas, Tracey DiSipio, Diana Battistutta, Wendy Demark-Wahnefried, Sheree Rye, John Bashford, Chris Pyke, Christobel Saunders, Sandra C Hayes

MiR-130b plays an oncogenic role by repressing PTEN expression in esophageal squamous cell carcinoma cells

• Open Access
• Research article

Tingting Yu, Risheng Cao, Shuo Li, Mingen Fu, Lihua Ren, Weixu Chen, Hong Zhu, Qiang Zhan, Ruihua Shi

Association of PALB2 sequence variants with the risk of familial and early-onset breast cancer in a South-American population

• Open Access
• Research article

Yessica Leyton, Patricio Gonzalez-Hormazabal, Rafael Blanco, Teresa Bravo, Ricardo Fernandez-Ramires, Sebastian Morales, Natalia Landeros, Jose M Reyes, Octavio Peralta, Julio C Tapia, Fernando Gomez, Enrique Waugh, Gladys Ibañez, Janara Pakomio, Gilberto Grau, Lilian Jara

MET FISH-positive status predicts short progression-free survival and overall survival after gefitinib treatment in lung adenocarcinoma with EGFR mutation

• Open Access
• Research article

Rintaro Noro, Masahiro Seike, Fenfei Zou, Chie Soeno, Kuniko Matsuda, Teppei Sugano, Nobuhiko Nishijima, Masaru Matsumoto, Kazuhiro Kitamura, Seiji Kosaihira, Yuji Minegishi, Akinobu Yoshimura, Kaoru Kubota, Akihiko Gemma

Retrospective review using targeted deep sequencing reveals mutational differences between gastroesophageal junction and gastric carcinomas

• Open Access
• Research article

Hector H Li-Chang, Katayoon Kasaian, Ying Ng, Amy Lum, Esther Kong, Howard Lim, Steven JM Jones, David G Huntsman, David F Schaeffer, Stephen Yip

Serum HE4 detects recurrent endometrial cancer in patients undergoing routine clinical surveillance

• Open Access
• Research article

Donal J Brennan, Andreas Hackethal, Kristy P Mann, Irene Mutz-Dehbalaie, Heidi Fiegl, Christian Marth, Andreas Obermair

RETRACTED ARTICLE: Melatonin attenuates the TLR4-mediated inflammatory response through MyD88- and TRIF-dependent signaling pathways in an in vivo model of ovarian cancer

• Open Access
• Research article

Luiz Gustavo A Chuffa, Beatriz A Fioruci-Fontanelli, Leonardo O Mendes, Fábio R Ferreira Seiva, Marcelo Martinez, Wagner J Fávaro, Raquel F Domeniconi, Patrícia FF Pinheiro, Lucilene Delazari dos Santos, Francisco Eduardo Martinez

High-density SNP arrays improve detection of HER2 amplification and polyploidy in breast tumors

• Open Access
• Research article

Thomas v O Hansen, Jonas Vikesaa, Sine S Buhl, Henrik H Rossing, Vera Timmermans-Wielenga, Finn C Nielsen

Concurrent paclitaxel-based chemo-radiotherapy for post-surgical microscopic residual tumor at the bronchial margin (R1 resection) in non-small-cell lung cancer

• Open Access
• Research article

Meixiang Zhou, Tao Li, Yongmei Liu, Changjin Sun, Na Li, Yong Xu, Jiang Zhu, Zhenyu Ding, Yongsheng Wang, Meijuan Huang, Feng Peng, Jin Wang, Li Ren, You Lu, Youling Gong

High levels of dietary soy decrease mammary tumor latency and increase incidence in MTB-IGFIR transgenic mice

• Open Access
• Research article

Katrina L Watson, Leanne Stalker, Robert A Jones, Roger A Moorehead

Cholangiocarcinoma: spectrum of appearances on Gd-EOB-DTPA-enhanced MR imaging and the effect of biliary function on signal intensity

• Open Access
• Research article

Shi-Ting Feng, Ling Wu, Huasong Cai, Tao Chan, Yanji Luo, Zhi Dong, Keguo Zheng, Zi-Ping Li

Trogocytosis-mediated expression of HER2 on immune cells may be associated with a pathological complete response to trastuzumab-based primary systemic therapy in HER2-overexpressing breast cancer patients

• Open Access
• Research article

Eiji Suzuki, Tatsuki R Kataoka, Masahiro Hirata, Kosuke Kawaguchi, Mariko Nishie, Hironori Haga, Masakazu Toi

Supervised physical exercise to improve the quality of life of cancer patients: the EFICANCER randomised controlled trial

• Open Access
• Study protocol

Aintzane Sancho, Sergio Carrera, Marisol Arietaleanizbeascoa, Veronica Arce, Nere Mendizabal Gallastegui, Anna Giné March, Aitor Sanz-Guinea, Araceli Eskisabel, Ana Lopez Rodriguez, Rosa A Martín, Guillermo Lopez-Vivanco, Gonzalo Grandes

Rosiglitazone may reduce non-melanoma skin cancer risk in Taiwanese

• Open Access
• Research article

Chin-Hsiao Tseng

Fluoroquinolone resistance in bacteremic and low risk febrile neutropenic patients with cancer

• Open Access
• Research article

Sheng Zhang, Qing Wang, Yun Ling, Xichun Hu

Number of negative lymph nodes is associated with disease-free survival in patients with breast cancer

• Open Access
• Research article

San-Gang Wu, Jia-Yuan Sun, Juan Zhou, Feng-Yan Li, Qin Lin, Huan-Xin Lin, Xun-Xing Guan, Zhen-Yu He

S100A4-neutralizing antibody suppresses spontaneous tumor progression, pre-metastatic niche formation and alters T-cell polarization balance

• Open Access
• Research article

Birgitte Grum-Schwensen, Jörg Klingelhöfer, Mette Beck, Charlotte Menné Bonefeld, Petra Hamerlik, Per Guldberg, Mariam Grigorian, Eugene Lukanidin, Noona Ambartsumian

Clonal distribution of BCR-ABL1 mutations and splice isoforms by single-molecule long-read RNA sequencing

• Open Access
• Research article

Lucia Cavelier, Adam Ameur, Susana Häggqvist, Ida Höijer, Nicola Cahill, Ulla Olsson-Strömberg, Monica Hermanson

Clinical outcome of patients with pancreatic metastases from renal cell cancer

• Open Access
• Research article

Takeshi Yuasa, Naoko Inoshita, Akio Saiura, Shinya Yamamoto, Shinji Urakami, Hitoshi Masuda, Yasuhisa Fujii, Iwao Fukui, Yuichi Ishikawa, Junji Yonese

GRECCAR 8: impact on survival of the primary tumor resection in rectal cancer with unresectable synchronous metastasis: a randomized multicentre study

• Open Access
• Study protocol

Eddy Cotte, Laurent Villeneuve, Guillaume Passot, Gilles Boschetti, Sylvie Bin-Dorel, Yves Francois, Olivier Glehen

NEOSCOPE: a randomised Phase II study of induction chemotherapy followed by either oxaliplatin/capecitabine or paclitaxel/carboplatin based chemoradiation as pre-operative regimen for resectable oesophageal adenocarcinoma

• Open Access
• Study protocol

Somnath Mukherjee, Christopher N Hurt, Sarah Gwynne, Andrew Bateman, Simon Gollins, Ganesh Radhakrishna, Maria Hawkins, Jo Canham, Wyn Lewis, Heike I Grabsch, Ricky A Sharma, Wendy Wade, Rhydian Maggs, Bethan Tranter, Ashley Roberts, David Sebag-Montefiore, Timothy Maughan, Gareth Griffiths, Tom Crosby

Occupational exposure and sinonasal cancer: a systematic review and meta-analysis

• Open Access
• Research article

Alessandra Binazzi, Pierpaolo Ferrante, Alessandro Marinaccio

YY1 suppresses FEN1 over-expression and drug resistance in breast cancer

• Open Access
• Research article

Jianwei Wang, Lina Zhou, Zhi Li, Ting Zhang, Wenpeng Liu, Zheng Liu, Yate-Ching Yuan, Fan Su, Lu Xu, Yan Wang, Xiaotong Zhou, Hong Xu, Yuejin Hua, Ying-Jie Wang, Li Zheng, Yue-E Teng, Binghui Shen

Impact of diabetes type II and chronic inflammation on pancreatic cancer

• Open Access
• Research article

Dietmar Zechner, Tobias Radecke, Jonas Amme, Florian Bürtin, Ann-Christin Albert, Lars Ivo Partecke, Brigitte Vollmar

Single arm NCRI phase II study of CHOP in combination with Ofatumumab in induction and maintenance for patients with newly diagnosed Richter’s syndrome

• Open Access
• Study protocol

Toby A Eyre, Ruth Clifford, Corran Roberts, Lucy Boyle, Anne Francis, Anna Schuh, Susan J Dutton

Co-expression of S100A14 and S100A16 correlates with a poor prognosis in human breast cancer and promotes cancer cell invasion

• Open Access
• Research article

Mizuko Tanaka, Naoki Ichikawa-Tomikawa, Namiko Shishito, Keisuke Nishiura, Tomiko Miura, Ayumi Hozumi, Hideki Chiba, Sayaka Yoshida, Tohru Ohtake, Takashi Sugino

Gamma knife radiosurgery for elderly patients with brain metastases: evaluation of scoring systems that predict survival

• Open Access
• Research article

Jae-Young Park, Kyung-Sub Moon, Kyung-Hwa Lee, Sa-Hoe Lim, Woo-Youl Jang, Hyeseon Lee, Tae-Young Jung, In-Young Kim, Shin Jung

The differential anti-tumour effects of zoledronic acid in breast cancer – evidence for a role of the activin signaling pathway

• Open Access
• Research article

Caroline Wilson, Penelope Ottewell, Robert E Coleman, Ingunn Holen

Plasma clusterin as a candidate pre-diagnosis marker of colorectal cancer risk in the Florence cohort of the European Prospective Investigation into Cancer and Nutrition: a pilot study

• Open Access
• Research article

Michela Bertuzzi, Cristina Marelli, Renzo Bagnati, Alessandro Colombi, Roberto Fanelli, Calogero Saieva, Marco Ceroti, Benedetta Bendinelli, Saverio Caini, Luisa Airoldi, Domenico Palli

Impact of age and gender on tumor related prognosis in gastrointestinal stromal tumors (GIST)

• Open Access
• Research article

Klaus Kramer, Uwe Knippschild, Benjamin Mayer, Kira Bögelspacher, Hanno Spatz, Doris Henne-Bruns, Abbas Agaimy, Matthias Schwab, Michael Schmieder

Melan-A/MART-1 immunity in a EWS-ATF1 translocated clear cell sarcoma patient treated with sunitinib: a case report

• Open Access
• Case report

Marcella Tazzari, Elena Palassini, Barbara Vergani, Antonello Villa, Francesca Rini, Tiziana Negri, Chiara Colombo, Flavio Crippa, Carlo Morosi, Paolo G Casali, Silvana Pilotti, Silvia Stacchiotti, Licia Rivoltini, Chiara Castelli

Phase II study of preoperative bevacizumab, capecitabine and radiotherapy for resectable locally-advanced rectal cancer

• Open Access
• Research article

Margarita García, Mercedes Martinez-Villacampa, Cristina Santos, Valentin Navarro, Alex Teule, Ferran Losa, Aleydis Pisa, Maria Cambray, Gemma Soler, Laura Lema, Esther Kreisler, Agnes Figueras, Xavier San Juan, Francesc Viñals, Sebastiano Biondo, Ramon Salazar

A randomized phase II study of capecitabine-based chemoradiation with or without bevacizumab in resectable locally advanced rectal cancer: clinical and biological features

• Open Access
• Research article

Ramon Salazar, Jaume Capdevila, Berta Laquente, Jose Luis Manzano, Carles Pericay, Mercedes Martínez Villacampa, Carlos López, Ferran Losa, Maria Jose Safont, Auxiliadora Gómez, Vicente Alonso, Pilar Escudero, Javier Gallego, Javier Sastre, Cristina Grávalos, Sebastiano Biondo, Amalia Palacios, Enrique Aranda

Next generation sequencing of exceptional responders with BRAF-mutant melanoma: implications for sensitivity and resistance

• Open Access
• Research article

Jennifer Wheler, Roman Yelensky, Gerald Falchook, Kevin B Kim, Patrick Hwu, Apostolia M Tsimberidou, Philip J Stephens, David Hong, Maureen T Cronin, Razelle Kurzrock

Adjuvant chemotherapy for stage III colon cancer: relative dose intensity and survival among veterans

• Open Access
• Research article

Sherrie L Aspinall, Chester B Good, Xinhua Zhao, Francesca E Cunningham, Bernadette B Heron, Mark Geraci, Vida Passero, Roslyn A Stone, Kenneth J Smith, Renee Rogers, Jenna Shields, Megan Sartore, D Patrick Boyle, Sherry Giberti, John Szymanski, Doug Smith, Allen Ha, Jolynn Sessions, Shawn Depcinski, Shane Fishco, Irvin Molina, Tanja Lepir, Carmela Jean, Lymaris Cruz-Diaz, Jessica Motta, Rebeca Calderon-Vargas, Janelle Maland, Sean Keefe, Marshall Tague, Alice Leone, Brian Glovack, Blair Kaplan, Sean Cosgriff, Lindsay Kaster, Ivy Tonnu-Mihara, Kimmai Nguyen, Jenna Carmichael, Linda Clifford, Kan Lu, Gurkamal Chatta

Return to work in sick-listed cancer survivors with job loss: design of a randomised controlled trial

• Open Access
• Study protocol

Martine P van Egmond, Saskia FA Duijts, Sylvia J Vermeulen, Allard J van der Beek, Johannes R Anema

Identification of a novel microRNA signature associated with intrahepatic cholangiocarcinoma (ICC) patient prognosis

• Open Access
• Research article

Mei-Yin Zhang, Shu-Hong Li, Guo-Liang Huang, Guo-He Lin, Ze-Yu Shuang, Xiang-Ming Lao, Li Xu, Xiao-Jun Lin, Hui-Yun Wang, Sheng-Ping Li

Significant correlation between urinary N1, N12-diacetylspermine and tumor invasiveness in patients with clinical stage IA non-small cell lung cancer

• Open Access
• Research article

Yusuke Takahashi, Hirotoshi Horio, Koji Sakaguchi, Kyoko Hiramatsu, Masao Kawakita

Breast and prostate cancer patients differ significantly in their serum Thymidine kinase 1 (TK1) specific activities compared with those hematological malignancies and blood donors: implications of using serum TK1 as a biomarker

• Open Access
• Research article

Kiran Kumar Jagarlamudi, Lars Olof Hansson, Staffan Eriksson

Increased expression of colony stimulating factor-1 is a predictor of poor prognosis in patients with clear-cell renal cell carcinoma

• Open Access
• Research article

Liu Yang, Qian Wu, Le Xu, Weijuan Zhang, Yu Zhu, Haiou Liu, Jiejie Xu, Jianxin Gu

Multiple myeloma cells alter the senescence phenotype of bone marrow mesenchymal stromal cells under participation of the DLK1-DIO3 genomic region

• Open Access
• Research article

Rimma Berenstein, Olga Blau, Axel Nogai, Marlies Waechter, Ekaterina Slonova, Martin Schmidt-Hieber, Annegret Kunitz, Antonio Pezzutto, Bernd Doerken, Igor Wolfgang Blau

Circadian variation in plasma 5-fluorouracil concentrations during a 24 hour constant-rate infusion

• Open Access
• Research article

Gini F Fleming, Philip Schumm, Greg Friberg, Mark J Ratain, Uchenna O Njiaju, Richard L Schilsky

Dermcidin exerts its oncogenic effects in breast cancer via modulation of ERBB signaling

• Open Access
• Research article

Jasna Bancovik, Dayson F Moreira, Daniel Carrasco, Jun Yao, Dale Porter, Ricardo Moura, Anamaria Camargo, Cibely C Fontes-Oliveira, Miguel G Malpartida, Silvia Carambula, Edouard Vannier, Bryan E Strauss, Alda Wakamatsu, Venancio AF Alves, Angela F Logullo, Fernando A Soares, Kornelia Polyak, José E Belizário

Targeting cMET with INC280 impairs tumour growth and improves efficacy of gemcitabine in a pancreatic cancer model

• Open Access
• Research article

Franziska Brandes, Katharina Schmidt, Christine Wagner, Julia Redekopf, Hans Jürgen Schlitt, Edward Kenneth Geissler, Sven Arke Lang

Sex differences in cancer survival in Estonia: a population-based study

• Open Access
• Research article

Kaire Innos, Peeter Padrik, Vahur Valvere, Tiiu Aareleid

Incidence, time course and independent risk factors for metachronous peritoneal carcinomatosis of gastric origin – a longitudinal experience from a prospectively collected database of 1108 patients

• Open Access
• Research article

Florian Seyfried, Burkhard H von Rahden, Alexander D Miras, Martin Gasser, Uwe Maeder, Volker Kunzmann, Christoph-Thomas Germer, Jörg OW Pelz, Alexander G Kerscher

Lung neuroendocrine tumors: correlation of ubiquitinylation and sumoylation with nucleo-cytosolic partitioning of PTEN

• Open Access
• Research article

Stéphane Collaud, Verena Tischler, Andrej Atanassoff, Thomas Wiedl, Paul Komminoth, Christian Oehlschlegel, Walter Weder, Alex Soltermann

Metaplastic breast cancer: a comparison between the most common histologies with poor immunohistochemistry factors

• Open Access
• Research article

Salim Abraham Barquet-Muñoz, Silvia Patricia Villarreal-Colin, Luis Alonso Herrera-Montalvo, Ernesto Soto-Reyes, Carlos Pérez-Plasencia, Jaime Coronel-Martínez, Delia Pérez-Montiel, Rafael Vázquez-Romo, David Cantú de León

Enhanced tumour cell nuclear targeting in a tumour progression model

• Open Access
• Research article

Michael S Nastasie, Helmut Thissen, David A Jans, Kylie M Wagstaff

Effects of supervised exercise on cancer-related fatigue in breast cancer survivors: a systematic review and meta-analysis

• Open Access
• Research article

José Francisco Meneses-Echávez, Emilio González-Jiménez, Robinson Ramírez-Vélez

A phase II study of weekly irinotecan in patients with locally advanced or metastatic HER2- negative breast cancer and increased copy numbers of the topoisomerase 1 (TOP1) gene: a study protocol

• Open Access
• Study protocol

Iben Kümler, Eva Balslev, Jan Stenvang, Nils Brünner, Dorte Nielsen

Local control in metastatic neuroblastoma in children over 1 year of age

• Open Access
• Research article

Maria Antonietta De Ioris, Alessandro Crocoli, Benedetta Contoli, Maria Carmen Garganese, Gianluigi Natali, Paolo Tomà, Alessandro Jenkner, Renata Boldrini, Maria Debora De Pasquale, Giuseppe Maria Milano, Silvia Madafferi, Aurora Castellano, Franco Locatelli, Alessandro Inserra

Gastric cancer-associated enhancement of von Willebrand factor is regulated by vascular endothelial growth factor and related to disease severity

• Open Access
• Research article

Xia Yang, Hai-jian Sun, Zhi-rong Li, Hao Zhang, Wei-jun Yang, Bing Ni, Yu-zhang Wu

Screening of exon 11 of BRCA1 gene using the high resolution melting approach for diagnosis in Moroccan breast cancer patients

• Open Access
• Technical advance

Meryam El Khachibi, Brehima Diakite, Khalil Hamzi, Abdallah Badou, Mohamed Amine Senhaji, Amina Bakhchane, Hassan Jouhadi, Abdelhamid Barakat, Abdellatif Benider, Sellama Nadifi

The role of HGF/MET and FGF/FGFR in fibroblast-derived growth stimulation and lapatinib-resistance of esophageal squamous cell carcinoma

• Open Access
• Research article

Shin Saito, Kazue Morishima, Takashi Ui, Hiroko Hoshino, Daisuke Matsubara, Shumpei Ishikawa, Hiroyuki Aburatani, Masashi Fukayama, Yoshinori Hosoya, Naohiro Sata, Alan K Lefor, Yoshikazu Yasuda, Toshiro Niki

The prognostic significance of age in operated and non-operated colorectal cancer

• Open Access
• Research article

Jing Li, Zhu Wang, Xin Yuan, Lichun Xu, Jiandong Tong

Human non-small cell lung cancer expresses putative cancer stem cell markers and exhibits the transcriptomic profile of multipotent cells

• Open Access
• Research article

Norashikin Zakaria, Narazah Mohd Yusoff, Zubaidah Zakaria, Moon Nian Lim, Puteri J Noor Baharuddin, Kamal Shaik Fakiruddin, Badrul Yahaya

Tumor evolution and intratumor heterogeneity of an epithelial ovarian cancer investigated using next-generation sequencing

• Open Access
• Research article

Jung-Yun Lee, Jung-Ki Yoon, Boyun Kim, Soochi Kim, Min A Kim, Hyeonseob Lim, Duhee Bang, Yong-Sang Song

HNRNP G and HTRA2-BETA1 regulate estrogen receptor alpha expression with potential impact on endometrial cancer

• Open Access
• Research article

Marc Hirschfeld, Yi Qin Ouyang, Markus Jaeger, Thalia Erbes, Marzenna Orlowska-Volk, Axel zur Hausen, Elmar Stickeler

Ipilimumab and immune-mediated adverse events: a case report of anti-CTLA4 induced ileitis

• Open Access
• Case report

Olga Venditti, Delia De Lisi, Marco Caricato, Damiano Caputo, Gabriella Teresa Capolupo, Chiara Taffon, Elisa Pagliara, Sofia Battisi, Anna Maria Frezza, Andrea Onetti Muda, Giuseppe Tonini, Daniele Santini

Epidermal growth factor receptor gene mutation status in pure squamous-cell lung cancer in Chinese patients

• Open Access
• Research article

Qing Zhang, Lei Zhu, Jie Zhang

Radiosensitization with combined use of olaparib and PI-103 in triple-negative breast cancer

• Open Access
• Research article

Na Young Jang, Dan Hyo Kim, Bong Jun Cho, Eun Jung Choi, Jong-Soo Lee, Hong-Gyun Wu, Eui Kyu Chie, In Ah Kim

Role of SMC1A overexpression as a predictor of poor prognosis in late stage colorectal cancer

• Open Access
• Research article

Jianwei Wang, Shaojun Yu, Liming Cui, Wenhui Wang, Jun Li, Ke Wang, Xinyuan Lao

Fibulin-4 is associated with tumor progression and a poor prognosis in ovarian carcinomas

• Open Access
• Research article

Jie Chen, Zhao Liu, Shuang Fang, Rui Fang, Xi Liu, Yueran Zhao, XiangXin Li, Lei Huang, Jie Zhang

MiRNA-141 and miRNA-200b are closely related to invasive ability and considered as decision-making biomarkers for the extent of PLND during cystectomy

• Open Access
• Research article

Wentao Liu, Lin Qi, Hui Lv, Xiongbing Zu, Minfeng Chen, Jun Wang, Longfei Liu, Feng Zeng, Yuan Li

ADAM12-L is a direct target of the miR-29 and miR-200 families in breast cancer

• Open Access
• Research article

Sara Duhachek-Muggy, Anna Zolkiewska

International trends in primary liver cancer incidence from 1973 to 2007

• Open Access
• Research article

Yue Zhang, Jian-Song Ren, Ju-Fang Shi, Ni Li, Yu-Ting Wang, Chunfeng Qu, Yawei Zhang, Min Dai

Is stereotactic radiosurgery a rational treatment option for brain metastases from small cell lung cancer? A retrospective analysis of 70 consecutive patients

• Open Access
• Research article

Shoji Yomo, Motohiro Hayashi

BMC Cancer reviewer acknowledgement 2014

• Open Access
• Reviewer acknowledgement

Dafne Solera

Resveratrol suppresses epithelial-to-mesenchymal transition in colorectal cancer through TGF-β1/Smads signaling pathway mediated Snail/E-cadherin expression

• Open Access
• Research article

Qing Ji, Xuan Liu, Zhifen Han, Lihong Zhou, Hua Sui, Linlin Yan, Haili Jiang, Jianlin Ren, Jianfeng Cai, Qi Li

The effect of individualized NUTritional counseling on muscle mass and treatment outcome in patients with metastatic COLOrectal cancer undergoing chemotherapy: a randomized controlled trial protocol

• Open Access
• Study protocol

Anne van der Werf, Susanne Blauwhoff-Buskermolen, Jacqueline AE Langius, Johannes Berkhof, Henk MW Verheul, Marian AE de van der Schueren

The association between human papillomavirus 16 and esophageal cancer in Chinese population: a meta-analysis

• Open Access
• Research article

Shao-Kai Zhang, Lan-Wei Guo, Qiong Chen, Meng Zhang, Shu-Zheng Liu, Pei-Liang Quan, Jian-Bang Lu, Xi-Bin Sun

The DNA load of six high-risk human papillomavirus types and its association with cervical lesions

• Open Access
• Research article

Luisa Del Río-Ospina, Sara Cecilia Soto-De León, Milena Camargo, Darwin Andrés Moreno-Pérez, Ricardo Sánchez, Antonio Pérez-Prados, Manuel Elkin Patarroyo, Manuel Alfonso Patarroyo

Tertiary lymphoid structures are associated with higher tumor grade in primary operable breast cancer patients

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Stine L Figenschau, Silje Fismen, Kristin A Fenton, Christopher Fenton, Elin S Mortensen

Nuclear expression of p65 (RelA) in patients receiving post-operative radiotherapy for locally advanced squamous cell carcinoma of the head and neck

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Dirk Rades, Stefan Huttenlocher, Nina D Seibold, Maximilian P Gebhard, Christoph Thorns, Katrin Hasselbacher, Barbara Wollenberg, Steven E Schild

Lymphangiogenesis in Gastric Cancer regulated through Akt/mTOR-VEGF-C/VEGF-D axis

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Hongxia Chen, Runnian Guan, Yupeng Lei, Jianyong Chen, Qi Ge, Xiaoshen Zhang, Ruoxu Dou, Hongyuan Chen, Hao Liu, Xiaolong Qi, Xiaodong Zhou, Changyan Chen

Cell type- and tumor zone-specific expression of pVEGFR-1 and its ligands influence colon cancer metastasis

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Caren Jayasinghe, Nektaria Simiantonaki, Charles James Kirkpatrick

Retrospective analysis of the impact of platinum dose reduction and chemotherapy delays on the outcomes of stage III ovarian cancer patients

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Sigita Liutkauskiene, Rasa Janciauskiene, Kristina Jureniene, Saulius Grizas, Rasa Malonyte, Elona Juozaityte

Vitamin D and cancer mortality in elderly women

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Germaine Wong, Wai Hon Lim, Joshua Lewis, Jonathan C Craig, Robin Turner, Kathy Zhu, Ee Mun Lim, Richard Prince

Astrocyte elevated gene-1(AEG-1) induces epithelial-mesenchymal transition in lung cancer through activating Wnt/β-catenin signaling

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Weiling He, Shanyang He, Zuo Wang, Hongwei Shen, Wenfeng Fang, Yang Zhang, Wei Qian, Millicent Lin, Jinglun Yuan, Jinyang Wang, Wenhua Huang, Liantang Wang, Zunfu Ke

The prognostic role of preoperative serum albumin levels in glioblastoma patients

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Sheng Han, Yanming Huang, Zhonghua Li, Haipei Hou, Anhua Wu

Inhibition of SHP2 in basal-like and triple-negative breast cells induces basal-to-luminal transition, hormone dependency, and sensitivity to anti-hormone treatment

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Hua Zhao, Yehenew M Agazie

Hunk/Mak-v is a negative regulator of intestinal cell proliferation

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Karen R Reed, Igor V Korobko, Natalia Ninkina, Elena V Korobko, Ben R Hopkins, James L Platt, Vladimir Buchman, Alan R Clarke

Impact of comorbidities and use of common medications on cancer and non-cancer specific survival in esophageal carcinoma

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Li-Ru He, Wei Qiao, Zhong-Xing Liao, Ritsuko Komaki, Linus Ho, Wayne L Hofstetter, Steven H Lin

The effect of chemotherapeutic agents on tumor vasculature in subcutaneous and orthotopic human tumor xenografts

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Andrea S Fung, Carol Lee, Man Yu, Ian F Tannock

Nuclear factor I-C regulates E-cadherin via control of KLF4 in breast cancer

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Hye-Kyung Lee, Dong-Seol Lee, Joo-Cheol Park

Clinically significant association between the maximum standardized uptake value on 18F-FDG PET and expression of phosphorylated Akt and S6 kinase for prediction of the biological characteristics of renal cell cancer

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Tomoya Mizuno, Takao Kamai, Hideyuki Abe, Setsu Sakamoto, Kazuhiro Kitajima, Daisaku Nishihara, Hideo Yuki, Tsunehito Kambara, Hironori Betsunoh, Masahiro Yashi, Yoshitatsu Fukabori, Yasushi Kaji, Ken-Ichiro Yoshida

Oromandibular dystonia: a serious side effect of capecitabine

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• Case report

Melanie JM van Pelt-Sprangers, Eric CT Geijteman, Jelmer Alsma, Ingrid A Boere, Ron HJ Mathijssen, Stephanie CE Schuit

The prognostic value of combined TGF-β1 and ELF in hepatocellular carcinoma

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Fei Ji, Shun-Jun Fu, Shun-Li Shen, Long-Juan Zhang, Qing-Hua Cao, Shao-Qiang Li, Bao-Gang Peng, Li-Jian Liang, Yun-Peng Hua

Prediction of resistance to chemotherapy in ovarian cancer: a systematic review

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Katherine L Lloyd, Ian A Cree, Richard S Savage

Overexpression of Nrf2 attenuates Carmustine-induced cytotoxicity in U87MG human glioma cells

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Sangeetha Sukumari-Ramesh, Niyathi Prasad, Cargill H Alleyne Jr, John R Vender, Krishnan M Dhandapani

Successful control of heavily pretreated metastatic gastric cancer with the mTOR inhibitor everolimus (RAD001) in a patient with PIK3CA mutation and pS6 overexpression

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• Case report

Ji Hyun Park, Min-Hee Ryu, Young Soo Park, Sook Ryun Park, Young-Soon Na, Baek-Yeol Rhoo, Yoon-Koo Kang

Can daily intake of aspirin and/or statins influence the behavior of non-muscle invasive bladder cancer? A retrospective study on a cohort of patients undergoing transurethral bladder resection

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Antonio Luigi Pastore, Giovanni Palleschi, Andrea Fuschi, Luigi Silvestri, Yazan Al Salhi, Elisabetta Costantini, Alessandro Zucchi, Vincenzo Petrozza, Cosimo de Nunzio, Antonio Carbone

Association of angiogenic factors with prognosis in esophageal cancer

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Lena Dreikhausen, Susanne Blank, Leila Sisic, Ulrike Heger, Wilko Weichert, Dirk Jäger, Thomas Bruckner, Natalia Giese, Lars Grenacher, Christine Falk, Katja Ott, Thomas Schmidt

Results of multicenter double-blind placebo-controlled phase II clinical trial of Panagen preparation to evaluate its leukostimulatory activity and formation of the adaptive immune response in patients with stage II-IV breast cancer

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Anastasia S Proskurina, Tatiana S Gvozdeva, Ekaterina A Alyamkina, Evgenia V Dolgova, Konstantin E Orishchenko, Valeriy P Nikolin, Nelly A Popova, Sergey V Sidorov, Elena R Chernykh, Alexandr A Ostanin, Olga Y Leplina, Victoria V Dvornichenko, Dmitriy M Ponomarenko, Galina S Soldatova, Nikolay A Varaksin, Tatiana G Ryabicheva, Stanislav N Zagrebelniy, Vladimir A Rogachev, Sergey S Bogachev, Mikhail A Shurdov

Lack of significant association between serum inflammatory cytokine profiles and the presence of colorectal adenoma

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Curtis J Henry, Rebecca L Sedjo, Andrii Rozhok, Jennifer Salstrom, Dennis Ahnen, Theodore R Levin, Ralph D’Agostino Jr, Steven Haffner, James DeGregori, Tim Byers

The association of alcohol consumption with mammographic density in a multiethnic urban population

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Zoe Quandt, Julie D Flom, Parisa Tehranifar, Diane Reynolds, Mary Beth Terry, Jasmine A McDonald

Microsatellite instability and mutations in BRAF and KRAS are significant predictors of disseminated disease in colon cancer

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Helgi Birgisson, Karolina Edlund, Ulrik Wallin, Lars Påhlman, Hanna Göransson Kultima, Markus Mayrhofer, Patrick Micke, Anders Isaksson, Johan Botling, Bengt Glimelius, Magnus Sundström

Patterns of chromosomal copy-number alterations in intrahepatic cholangiocarcinoma

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Cyril Dalmasso, Wassila Carpentier, Catherine Guettier, Sophie Camilleri-Broët, Wyllians Vendramini Borelli, Cedália Rosane Campos dos Santos, Denis Castaing, Jean-Charles Duclos-Vallée, Philippe Broët

Study protocol of REGOSARC trial: activity and safety of regorafenib in advanced soft tissue sarcoma: a multinational, randomized, placebo-controlled, phase II trial

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• Study protocol

Thomas Brodowicz, Bernadette Liegl-Atzwager, Emmanuelle Tresch, Sophie Taieb, Andrew Kramar, Viktor Gruenwald, Marie Vanseymortier, Stéphanie Clisant, Jean-Yves Blay, Axel Le Cesne, Nicolas Penel

The significance of the co-existence of osteopontin and tumor-associated macrophages in gastric cancer progression

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Chang-Ni Lin, Chih-Jung Wang, Ying-Jui Chao, Ming-Derg Lai, Yan-Shen Shan

Surface antigen expression on peripheral blood monocytes in women with gynecologic malignancies

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Maciej Jóźwik, Osazee E Okungbowa, Alina Lipska, Marcin Jóźwik, Marzena Smoktunowicz, Andrzej Semczuk, Michał Jóźwik, Piotr Radziwon

A functional in vitro model of heterotypic interactions reveals a role for interferon-positive carcinoma associated fibroblasts in breast cancer

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Abdel Nasser Hosein, Julie Livingstone, Marguerite Buchanan, James F Reid, Michael Hallett, Mark Basik

eIF6 over-expression increases the motility and invasiveness of cancer cells by modulating the expression of a critical subset of membrane-bound proteins

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Michela Pinzaglia, Claudia Montaldo, Dorina Polinari, Mattei Simone, Anna La Teana, Marco Tripodi, Carmine Mancone, Paola Londei, Dario Benelli

COP1, the negative regulator of ETV1, influences prognosis in triple-negative breast cancer

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Mao Ouyang, Hua Wang, Jieyi Ma, Weiming Lü, Jie Li, Chen Yao, Guangqi Chang, Jiong Bi, Shenming Wang, Wenjian Wang

Risk of cancer among HIV-infected patients from a population-based nested case–control study: implications for cancer prevention

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Chang-Hua Chen, Chih-Yuan Chung, Li-Hsuan Wang, Che Lin, Hsiu-Li Lin, Hsiu-Chen Lin

Cyproheptadine, an antihistaminic drug, inhibits proliferation of hepatocellular carcinoma cells by blocking cell cycle progression through the activation of P38 MAP kinase

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Yu-Min Feng, Chin-Wen Feng, Syue-Yi Chen, Hsiao-Yen Hsieh, Yu-Hsin Chen, Cheng-Da Hsu

Low levels of IGFBP7 expression in high-grade serous ovarian carcinoma is associated with patient outcome

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Karen Gambaro, Michael CJ Quinn, Katia Y Cáceres-Gorriti, Rebecca S Shapiro, Diane Provencher, Kurosh Rahimi, Anne-Marie Mes-Masson, Patricia N Tonin

Dose-response relationship in cisplatin-treated breast cancer xenografts monitored with dynamic contrast-enhanced ultrasound

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Yao Chen, Feng Han, Long-hui Cao, Cheng Li, Jian-wei Wang, Qing Li, Wei Zheng, Zhi-xing Guo, An-hua Li, Jian-hua Zhou

Alterations in anatomic and functional imaging parameters with repeated FDG PET-CT and MRI during radiotherapy for head and neck cancer: a pilot study

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Manil Subesinghe, Andrew F Scarsbrook, Steven Sourbron, Daniel J Wilson, Garry McDermott, Richard Speight, Neil Roberts, Brendan Carey, Roan Forrester, Sandeep Vijaya Gopal, Jonathan R Sykes, Robin JD Prestwich

Poor prognosis of single hormone receptor- positive breast cancer: similar outcome as triple-negative breast cancer

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Soo Youn Bae, Sangmin Kim, Jun Ho Lee, Hyun-chul Lee, Se Kyung Lee, Won Ho Kil, Seok Won Kim, Jeong Eon Lee, Seok Jin Nam

Annonaceous acetogenin mimic AA005 induces cancer cell death via apoptosis inducing factor through a caspase-3-independent mechanism

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Bing Han, Tong-Dan Wang, Shao-Ming Shen, Yun Yu, Chan Mao, Zhu-Jun Yao, Li-Shun Wang

Phosphorylation of pyruvate kinase M2 and lactate dehydrogenase A by fibroblast growth factor receptor 1 in benign and malignant thyroid tissue

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Paul Kachel, Bogusz Trojanowicz, Carsten Sekulla, Hanna Prenzel, Henning Dralle, Cuong Hoang-Vu

Genomics driven-oncology: challenges and perspectives

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Nicola Normanno, Ian A Cree

Detection of morphologic alterations in rectal carcinoma following preoperative radiochemotherapy based on multiphoton microscopy imaging

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Lianhuang Li, Zhifen Chen, Xingfu Wang, Hongsheng Li, Weizhong Jiang, Shuangmu Zhuo, Guoxian Guan, Jianxin Chen

Associations between breast density and a panel of single nucleotide polymorphisms linked to breast cancer risk: a cohort study with digital mammography

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Brad M Keller, Anne Marie McCarthy, Jinbo Chen, Katrina Armstrong, Emily F Conant, Susan M Domchek, Despina Kontos

HIV testing and burden of HIV infection in black cancer patients in Johannesburg, South Africa: a cross-sectional study

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Mazvita Sengayi, Chantal Babb, Matthias Egger, Margaret I Urban

Critical evaluation of Cbx7 downregulation in primary colon carcinomas and its clinical significance in Chinese patients

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Xiang Zheng, Jing Zhou, Baozhen Zhang, Jun Zhang, James Wilson, Liankun Gu, Budong Zhu, Jin Gu, Jiafu Ji, Dajun Deng

Prevalence and outcomes of extrahepatic primary malignancy associated with Hepatocellular Carcinoma in a Korean population

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Sukho Hong, Sook-Hyang Jeong, Sang Soo Lee, Jung Wha Chung, Sung Wook Yang, Seong Min Chung, Eun Sun Jang, Jin-Wook Kim, Jee Hyun Kim, Haeryoung Kim, Jai Young Cho, Yoo-Seok Yoon, Ho-Seong Han

No significant viral transcription detected in whole breast cancer transcriptomes

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Danai Fimereli, David Gacquer, Debora Fumagalli, Roberto Salgado, Françoise Rothé, Denis Larsimont, Christos Sotiriou, Vincent Detours

Prognostic role of serum p53 antibodies in lung cancer

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Manlio Mattioni, Silvia Soddu, Andrea Prodosmo, Paolo Visca, Salvatore Conti, Gabriele Alessandrini, Francesco Facciolo, Lidia Strigari

Are urothelial carcinomas of the upper urinary tract a distinct entity from urothelial carcinomas of the urinary bladder? Behavior of urothelial carcinoma after radical surgery with respect to anatomical location: a case control study

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Myong Kim, Chang Wook Jeong, Cheol Kwak, Hyeon Hoe Kim, Ja Hyeon Ku

NAT1 and NAT2 genetic polymorphisms and environmental exposure as risk factors for oesophageal squamous cell carcinoma: a case-control study

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Marco Matejcic, Matjaz Vogelsang, Yabing Wang, Iqbal M Parker

Cancers of unknown primary origin (CUP) are characterized by chromosomal instability (CIN) compared to metastasis of know origin

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Jonas Vikeså, Anne Kirstine H Møller, Bogumil Kaczkowski, Rehannah Borup, Ole Winther, Ricardo Henao, Anders Krogh, Katharina Perell, Flemming Jensen, Gedske Daugaard, Finn C Nielsen

Mechanisms of tumor-promoting activities of nicotine in lung cancer: synergistic effects of cell membrane and mitochondrial nicotinic acetylcholine receptors

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Alex I Chernyavsky, Igor B Shchepotin, Valentin Galitovkiy, Sergei A Grando

Total and partial cancer prevalence in the adult French population in 2008

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Marc Colonna, Nicolas Mitton, Nadine Bossard, Aurelien Belot, Pascale Grosclaude

Efficacy of pazopanib monotherapy in patients who had been heavily pretreated for metastatic soft tissue sarcoma: a retrospective case series

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Kwai Han Yoo, Hyo Song Kim, Su Jin Lee, Se Hoon Park, Sung Joo Kim, Soo Hee Kim, Yoon La Choi, Kyoo-Ho Shin, Yong Jin Cho, Jeeyun Lee, Sun Young Rha

Prognostic relevance of positive urine markers in patients with negative cystoscopy during surveillance of bladder cancer

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Tilman Todenhöfer, Jörg Hennenlotter, Philipp Guttenberg, Sarah Mohrhardt, Ursula Kuehs, Michael Esser, Stefan Aufderklamm, Simone Bier, Niklas Harland, Steffen Rausch, Georgios Gakis, Arnulf Stenzl, Christian Schwentner

Systematic review of the predictive effect of MSI status in colorectal cancer patients undergoing 5FU-based chemotherapy

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Elizabeth M Webber, Tia L Kauffman, Elizabeth O’Connor, Katrina AB Goddard

A mutation screening of oncogenes, tumor suppressor gene TP53 and nuclear encoded mitochondrial complex I genes in oncocytic thyroid tumors

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Cecilia Evangelisti, Dario de Biase, Ivana Kurelac, Claudio Ceccarelli, Holger Prokisch, Thomas Meitinger, Paola Caria, Roberta Vanni, Giovanni Romeo, Giovanni Tallini, Giuseppe Gasparre, Elena Bonora

Paired design study by real-time PCR: miR-378* and miR-145 are potent early diagnostic biomarkers of human colorectal cancer

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Juan Peng, Zhengyong Xie, Liyang Cheng, Yuxin Zhang, Junyong Chen, Hongping Yu, Zehang Li, Huixing Kang

Anticancer activity of a thymidine quinoxaline conjugate is modulated by cytosolic thymidine pathways

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Qiong Wei, Haijuan Liu, Honghao Zhou, Dejun Zhang, Zhiwei Zhang, Qibing Zhou

Heterogeneity analysis of Metastasis Associated in Colon Cancer 1 (MACC1) for survival prognosis of colorectal cancer patients: a retrospective cohort study

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Viktor H Koelzer, Pia Herrmann, Inti Zlobec, Eva Karamitopoulou, Alessandro Lugli, Ulrike Stein

Induction of tumor initiation is dependent on CD44s in c-Met+ hepatocellular carcinoma

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Hien Dang, Steven N Steinway, Wei Ding, Carl B Rountree

The impact of supplementary narrative-based information on colorectal cancer screening beliefs and intention

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Lesley M McGregor, Christian von Wagner, Gemma Vart, Wing Chee Yuen, Rosalind Raine, Jane Wardle, Kathryn A Robb

Resolution of severe hyponatraemia is associated with improved survival in patients with cancer

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Kirsty Balachandran, Alicia Okines, Ranga Gunapala, Daniel Morganstein, Sanjay Popat

The tumour-promoting receptor tyrosine kinase, EphB4, regulates expression of Integrin-β8 in prostate cancer cells

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Inga Mertens-Walker, Bruno C Fernandini, Mohanan SN Maharaj, Anja Rockstroh, Colleen C Nelson, Adrian C Herington, Sally-Anne Stephenson

The efficacy and safety of irreversible electroporation for the ablation of renal masses: a prospective, human, in-vivo study protocol

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• Study protocol

Peter GK Wagstaff, Daniel M de Bruin, Patricia J Zondervan, C Dilara Savci Heijink, Marc RW Engelbrecht, Otto M van Delden, Ton G van Leeuwen, Hessel Wijkstra, Jean JMCH de la Rosette, M Pilar Laguna Pes

Overexpression of 17β-hydroxysteroid dehydrogenase type 10 increases pheochromocytoma cell growth and resistance to cell death

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Emily A Carlson, Rebecca T Marquez, Fang Du, Yongfu Wang, Liang Xu, Shirley ShiDu Yan

Identifying a low-risk group for parametrial involvement in microscopic Stage IB1 cervical cancer using criteria from ongoing studies and a new MRI criterion

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Jung-Yun Lee, Jina Youm, Jae-Weon Kim, Jeong Yeon Cho, Min A Kim, Tae Hun Kim, Dong Hoon Suh, Myong Cheol Lim, Noh Hyun Park, Yong-Sang Song

Prediction of long noncoding RNA functions with co-expression network in esophageal squamous cell carcinoma

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Yibin Hao, Wei Wu, Fachun Shi, Rodrigo JS Dalmolin, Ming Yan, Fu Tian, Xiaobing Chen, Guoyong Chen, Wei Cao

Transcriptional expression of 8 genes predicts pathological response to first-line docetaxel + trastuzumab-based neoadjuvant chemotherapy

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Esther Schmitt, Frédérique Végran, Sandy Chevrier, Laura Burillier, Muriel Cadouot, Sarab Lizard-Nacol, Bruno Coudert, Pierre Fumoleau, Laurent Arnould, Romain Boidot

A novel engineered VEGF blocker with an excellent pharmacokinetic profile and robust anti-tumor activity

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Lily Liu, Haijia Yu, Xin Huang, Hongzhi Tan, Song Li, Yan Luo, Li Zhang, Sumei Jiang, Huifeng Jia, Yao Xiong, Ruliang Zhang, Yi Huang, Charles C Chu, Wenzhi Tian

A retrospective analysis of RET translocation, gene copy number gain and expression in NSCLC patients treated with vandetanib in four randomized Phase III studies

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Adam Platt, John Morten, Qunsheng Ji, Paul Elvin, Chris Womack, Xinying Su, Emma Donald, Neil Gray, Jessica Read, Graham Bigley, Laura Blockley, Carl Cresswell, Angela Dale, Amanda Davies, Tianwei Zhang, Shuqiong Fan, Haihua Fu, Amanda Gladwin, Grace Harrod, James Stevens, Victoria Williams, Qingqing Ye, Li Zheng, Richard de Boer, Roy S Herbst, Jin-Soo Lee, James Vasselli

Ras induces experimental lung metastasis through up-regulation of RbAp46 to suppress RECK promoter activity

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Hsuan-Heng Yeh, Yu-Fen Tseng, Yu-Chiao Hsu, Sheng-Hui Lan, Shan-Ying Wu, Giri Raghavaraju, Da-En Cheng, Ying-Ray Lee, Tsuey-Yu Chang, Nan-Haw Chow, Wen-Chun Hung, Hsiao-Sheng Liu

Erratum: Preoperative chemosensitivity testing as Predictor of Treatment benefit in Adjuvant stage III colon cancer (PePiTA): Protocol of a prospective BGDO (Belgian Group for Digestive Oncology) multicentric study

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• Erratum

Alain Hendlisz, Vassilis Golfinopoulos, Amelie Deleporte, Marianne Paesmans, Hazem El Mansy, Camilo Garcia, Marc Peeters, Lieven Annemans, Caroline Vandeputte, Marion Maetens, Marc Van den Eynde, Raphaël Maréchal, Ivan Borbath, Damien Dresse, Ghislain Houbiers, Michael Fried, Ahmad Awada, Martine Piccart, Jean-Luc Van Laethem, Patrick Flamen

Photodynamic diagnosis of pleural malignant lesions with a combination of 5-aminolevulinic acid and intrinsic fluorescence observation systems

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Masahiro Kitada, Yoshinobu Ohsaki, Yoshinari Matsuda, Satoshi Hayashi, Kei Ishibashi

A retrospective chart review of drug treatment patterns and clinical outcomes among patients with metastatic or recurrent soft tissue sarcoma refractory to one or more prior chemotherapy treatments

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Michael J Wagner, Leo Ismaila Amodu, Mei Sheng Duh, Caroline Korves, Franco Solleza, Stephanie C Manson, José Diaz, Maureen P Neary, George D Demetri

Multicenter phase II study of FOLFIRI plus bevacizumab after discontinuation of oxaliplatin-based regimen for advanced or recurrent colorectal cancer (CR0802)

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Mitsukuni Suenaga, Tomohiro Nishina, Nobuyuki Mizunuma, Hisateru Yasui, Takashi Ura, Tadamichi Denda, Junichi Ikeda, Taito Esaki, Hogara Nishisaki, Yoshinao Takano, Yasuyuki Sugiyama, Kei Muro

Dietary cadmium intake and risk of prostate cancer: a Danish prospective cohort study

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Kirsten T Eriksen, Jytte Halkjær, Jaymie R Meliker, Jane A McElroy, Mette Sørensen, Anne Tjønneland, Ole Raaschou-Nielsen

Epithelial-mesenchymal plasticity is a decisive feature for the metastatic outgrowth of disseminated WAP-T mouse mammary carcinoma cells

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Claudia Maenz, Eva Lenfert, Klaus Pantel, Udo Schumacher, Wolfgang Deppert, Florian Wegwitz

Evaluation of public cancer datasets and signatures identifies TP53 mutant signatures with robust prognostic and predictive value

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Brian David Lehmann, Yan Ding, Daniel Joseph Viox, Ming Jiang, Yi Zheng, Wang Liao, Xi Chen, Wei Xiang, Yajun Yi

Neo-adjuvant chemotherapy followed by surgery versus surgery alone in high-risk patients with resectable colorectal liver metastases: the CHARISMA randomized multicenter clinical trial

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• Study protocol

Ninos Ayez, Eric P van der Stok, Hans de Wilt, Sandra A Radema, Richard van Hillegersberg, Rudi M Roumen, Gerard Vreugdenhil, Pieter J Tanis, Cornelis J Punt, Cornelis H Dejong, Rob L Jansen, Henk M Verheul, Koert P de Jong, Geke A Hospers, Joost M Klaase, Marie-Cecile Legdeur, Esther van Meerten, Ferry A Eskens, Nelly van der Meer, Bruno van der Holt, Cornelis Verhoef, Dirk J Grünhagen

BRCA1 germline mutation and glioblastoma development: report of cases

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Meriem Boukerroucha, Claire Josse, Karin Segers, Sonia El-Guendi, Pierre Frères, Guy Jerusalem, Vincent Bours

Low mir-372 expression correlates with poor prognosis and tumor metastasis in hepatocellular carcinoma

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Gang Wu, Yawei Wang, Xiaojun Lu, Hui He, Haiyang Liu, Xiangyu Meng, Shuguan Xia, Kunming Zheng, Boqian Liu

Breast cancer and neurofibromatosis type 1: a diagnostic challenge in patients with a high number of neurofibromas

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• Case report

André Vallejo Da Silva, Fabiana Resende Rodrigues, Mônica Pureza, Vania Gloria Silami Lopes, Karin Soares Cunha

Sorafenib inhibits intracellular signaling pathways and induces cell cycle arrest and cell death in thyroid carcinoma cells irrespective of histological origin or BRAF mutational status

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Martina Broecker-Preuss, Stefan Müller, Martin Britten, Karl Worm, Kurt Werner Schmid, Klaus Mann, Dagmar Fuhrer

A population-based study of incidence and patient survival of small cell carcinoma in the United States, 1992–2010

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Graça M Dores, Osama Qubaiah, Ankur Mody, Bassam Ghabach, Susan S Devesa

Factors influencing participation in a randomized controlled resistance exercise intervention study in breast cancer patients during radiotherapy

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Sandra M Gollhofer, Joachim Wiskemann, Martina E Schmidt, Oliver Klassen, Cornelia M Ulrich, Jan Oelmann, Holger Hof, Karin Potthoff, Karen Steindorf

Retraction Note: STMN-1 is a potential marker of lymph node metastasis in distal esophageal adenocarcinomas and silencing its expression can reverse malignant phenotype of tumor cells

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• Retraction Note

Javed Akhtar, Zhou Wang, Che Yu, Chen-Sheng Li, Yu-Long Shi, Hong-Jun Liu

The role of multipotent cancer associated fibroblasts in hepatocarcinogenesis

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Caecilia Hapsari Ceriapuri Sukowati, Beatrice Anfuso, Lory Saveria Crocé, Claudio Tiribelli

NPC1L1 knockout protects against colitis-associated tumorigenesis in mice

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Jianming He, Hyunsu Shin, Xing Wei, Anil Kumar G Kadegowda, Rui Chen, Sandy Krystal Xie

The role of androgen deprivation therapy on biochemical failure and distant metastasis in intermediate-risk prostate cancer: effects of radiation dose escalation

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Michelle S Ludwig, Deborah A Kuban, Xianglin L Du, David S Lopez, Jose-Miguel Yamal, Sara S Strom

Residential environment and breast cancer incidence and mortality: a systematic review and meta-analysis

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Tomi F Akinyemiju, Jeanine M Genkinger, Maggie Farhat, Adrienne Wilson, Tiffany L Gary-Webb, Parisa Tehranifar

Ion therapy within the trimodal management of superior sulcus tumors: the INKA trial

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• Study protocol

Henrik Hauswald, Stefan Rieken, Hendrik C Dienemann, Michael Thomas, Meinhard Kieser, Jürgen Debus, Klaus Herfarth

Feasibility of urinary microRNA detection in breast cancer patients and its potential as an innovative non-invasive biomarker

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Thalia Erbes, Marc Hirschfeld, Gerta Rücker, Markus Jaeger, Jasmin Boas, Severine Iborra, Sebastian Mayer, Gerald Gitsch, Elmar Stickeler

Association between CHEK2 H371Y mutation and response to neoadjuvant chemotherapy in women with breast cancer

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Yin Liu, Ye Xu, Tao Ouyang, Jinfeng Li, Tianfeng Wang, Zhaoqing Fan, Tie Fan, Benyao Lin, Yuntao Xie

Pre-treatment neutrophil to lymphocyte ratio may be a useful tool in predicting survival in early triple negative breast cancer patients

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Mirco Pistelli, Mariagrazia De Lisa, Zelmira Ballatore, Miriam Caramanti, Alessandra Pagliacci, Nicola Battelli, Francesca Ridolfi, Matteo Santoni, Elena Maccaroni, Raffaella Bracci, Alfredo Santinelli, Tommasina Biscotti, Rossana Berardi, Stefano Cascinu

Topotecan synergizes with CHEK1 (CHK1) inhibitor to induce apoptosis in ovarian cancer cells

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Marianne K Kim, Jana James, Christina M Annunziata

Sumoylation of Kif18A plays a role in regulating mitotic progression

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Feikun Yang, Yan Chen, Wei Dai

Prognostic significance of interim PET/CT based on visual, SUV-based, and MTV-based assessment in the treatment of peripheral T-cell lymphoma

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Sung-Hoon Jung, Jae-Sook Ahn, Yeo-Kyeoung Kim, Sun-Seog Kweon, Jung-Joon Min, Hee-Seung Bom, Hyeoung-Joon Kim, Yee Soo Chae, Joon Ho Moon, Sang Kyun Sohn, Sang Woo Lee, Byung Hyun Byun, Young Rok Do, Je-Jung Lee, Deok-Hwan Yang

A multiplexed, targeted mass spectrometry assay of the S100 protein family uncovers the isoform-specific expression in thyroid tumours

• Open Access
• Technical advance

Juan Martínez-Aguilar, Roderick Clifton-Bligh, Mark P Molloy

The leukemia inhibitory factor (LIF) and p21 mediate the TGFβ tumor suppressive effects in human cutaneous melanoma

• Open Access
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Laure Humbert, Mostafa Ghozlan, Lucie Canaff, Jun Tian, Jean-Jacques Lebrun

Luminal B subtype: A key factor for the worse prognosis of young breast cancer patients in China

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Li-Chen Tang, Xi Jin, Hai-Yuan Yang, Min He, Helena Chang, Zhi-Ming Shao, Gen-Hong Di

Meta-analysis of the prognostic value of circulating tumor cells detected with the CellSearch System in colorectal cancer

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Xuanzhang Huang, Peng Gao, Yongxi Song, Jingxu Sun, Xiaowan Chen, Junhua Zhao, Huimian Xu, Zhenning Wang

MTUS1/ATIP3a down-regulation is associated with enhanced migration, invasion and poor prognosis in salivary adenoid cystic carcinoma

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Tingting Zhao, Xueqiang Ding, Boyang Chang, Xiaofeng Zhou, Anxun Wang

Androgen receptor and chemokine receptors 4 and 7 form a signaling axis to regulate CXCL12-dependent cellular motility

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Jordy J Hsiao, Brandon H Ng, Melinda M Smits, Jiahui Wang, Rohini J Jasavala, Harryl D Martinez, Jinhee Lee, Jhullian J Alston, Hiroaki Misonou, James S Trimmer, Michael E Wright

Homozygous deletions of UGT2B17 modifies effects of smoking on TP53-mutations and relapse of head and neck carcinoma

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Aki Mafune, Takanori Hama, Toshihito Suda, Yutaka Suzuki, Masahiro Ikegami, Chikako Sakanashi, Satoko Imai, Akio Nakashima, Takashi Yokoo, Kota Wada, Hiromi Kojima, Mitsuyoshi Urashima

Circulating tumor cells in hepatocellular carcinoma: a pilot study of detection, enumeration, and next-generation sequencing in cases and controls

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Robin K Kelley, Mark Jesus M Magbanua, Timothy M Butler, Eric A Collisson, Jimmy Hwang, Nikoletta Sidiropoulos, Kimberley Evason, Ryan M McWhirter, Bilal Hameed, Elizabeth M Wayne, Francis Y Yao, Alan P Venook, John W Park

NQO1 protein expression predicts poor prognosis of non-small cell lung cancers

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Zhenling Li, Yue Zhang, Tiefeng Jin, Jiguang Men, Zhenhua Lin, Peng Qi, Yingshi Piao, Guanghai Yan

Murine double minute 2 predicts response of advanced esophageal squamous cell carcinoma to definitive chemoradiotherapy

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Hiroshi Okamoto, Fumiyoshi Fujishima, Takashi Kamei, Yasuhiro Nakamura, Yohei Ozawa, Go Miyata, Toru Nakano, Kazunori Katsura, Shigeo Abe, Yusuke Taniyama, Tadashi Sakurai, Jin Teshima, Makoto Hikage, Hironobu Sasano, Noriaki Ohuchi

Prognostic value of carbonic anhydrase VII expression in colorectal carcinoma

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Guang-Zhen Yang, Liang Hu, Jian Cai, Hai-Yang Chen, Yu Zhang, Dan Feng, Chen-Ye Qi, Yan-Xia Zhai, Hui Gong, Hao Fu, Qing-Ping Cai, Chun-Fang Gao

Treatment and survival of non-alcoholic steatohepatitis associated hepatocellular carcinoma

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Arndt Weinmann, Yvonne Alt, Sandra Koch, Carina Nelles, Christoph Düber, Hauke Lang, Gerd Otto, Tim Zimmermann, Jens U Marquardt, Peter R Galle, Marcus A Wörns, Jörn M Schattenberg

Effects of payer status on breast cancer survival: a retrospective study

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Runhua Shi, Hannah Taylor, Jerry McLarty, Lihong Liu, Glenn Mills, Gary Burton

Lack of a protective effect of cotton dust on risk of lung cancer: evidence from two population-based case-control studies

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Krista Yorita Christensen, Jérôme Lavoué, Marie-Claude Rousseau, Jack Siemiatycki

Sentinel lymph node detection using magnetic resonance lymphography with conventional gadolinium contrast agent in breast cancer: a preliminary clinical study

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Chuanming Li, Shan Meng, Xinhua Yang, Daiquan Zhou, Jian Wang, Jiani Hu

Availability and outcomes of radiotherapy in Central Poland during the 2005-2012 period - an observational study

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Justyna Chalubinska-Fendler, Wojciech Fendler, Michal Spych, Jolanta Luniewska-Bury, Wojciech Mlynarski, Jacek Fijuth

Development and analytical validation of a 25-gene next generation sequencing panel that includes the BRCA1 and BRCA2 genes to assess hereditary cancer risk

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• Technical advance

Thaddeus Judkins, Benoît Leclair, Karla Bowles, Natalia Gutin, Jeff Trost, James McCulloch, Satish Bhatnagar, Adam Murray, Jonathan Craft, Bryan Wardell, Mark Bastian, Jeffrey Mitchell, Jian Chen, Thanh Tran, Deborah Williams, Jennifer Potter, Srikanth Jammulapati, Michael Perry, Brian Morris, Benjamin Roa, Kirsten Timms

Comparison of analytical and clinical performance of CLART HPV2 genotyping assay to Linear Array and Hybrid Capture 2: a split-sample study

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Ditte Møller Ejegod, Matejka Rebolj, Jesper Bonde

Direct confirmation of quiescence of CD34+CD38- leukemia stem cell populations using single cell culture, their molecular signature and clinicopathological implications

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Eun Jeong Won, Hye-Ran Kim, Ra-Young Park, Seok-Yong Choi, Jong Hee Shin, Soon-Pal Suh, Dong-Wook Ryang, Michael Szardenings, Myung-Geun Shin

Improvement of the initial management of sarcomas after the dissemination of evidence-based guidelines depends on the primary sarcoma location: a population-based study

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Karine Ligier, Carlos Maynou, Xavier Leroy, Yves-Marie Robin, Philippe Martin, Stéphanie Clisant, Florence Richard, Nicolas Penel

BRCA1 Alternative splicing landscape in breast tissue samples

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Atocha Romero, Francisco García-García, Irene López-Perolio, Gorka Ruiz de Garibay, José A García-Sáenz, Pilar Garre, Patricia Ayllón, Esperanza Benito, Joaquín Dopazo, Eduardo Díaz-Rubio, Trinidad Caldés, Miguel de la Hoya

The role of histologic subtype, p16INK4a expression, and presence of human papillomavirus DNA in penile squamous cell carcinoma

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Julie Steinestel, Andreas Al Ghazal, Annette Arndt, Thomas J Schnoeller, Andres J Schrader, Peter Moeller, Konrad Steinestel

A pooled shRNA screen for regulators of primary mammary stem and progenitor cells identifies roles for Asap1 and Prox1

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Julie M Sheridan, Matthew E Ritchie, Sarah A Best, Kun Jiang, Tamara J Beck, François Vaillant, Kevin Liu, Ross A Dickins, Gordon K Smyth, Geoffrey J Lindeman, Jane E Visvader

Abiraterone acetate in patients with metastatic castration-resistant prostate cancer: long term outcome of the Temporary Authorization for Use programme in France

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Nadine Houédé, Philippe Beuzeboc, Sophie Gourgou, Diego Tosi, Laura Moise, Gwenaëlle Gravis, Remy Delva, Aude Fléchon, Igor Latorzeff, Jean-Marc Ferrero, Stéphane Oudard, Sophie Tartas, Brigitte Laguerre, Delphine Topart, Guilhem Roubaud, Hanane Agherbi, Xavier Rebillard, David Azria

Human pancreatic cancer stem cells are sensitive to dual inhibition of IGF-IR and ErbB receptors

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Nerea Urtasun, Anna Vidal-Pla, Sandra Pérez-Torras, Adela Mazo

Chemoresistance is associated with increased cytoprotective autophagy and diminished apoptosis in bladder cancer cells treated with the BH3 mimetic (−)-Gossypol (AT-101)

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Jens Mani, Stefan Vallo, Stefanie Rakel, Patrick Antonietti, Florian Gessler, Roman Blaheta, Georg Bartsch, Martin Michaelis, Jindrich Cinatl, Axel Haferkamp, Donat Kögel

γ-Glutamyl transferase 7 is a novel regulator of glioblastoma growth

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Timothy T Bui, Ryan T Nitta, Suzana A Kahn, Seyed-Mostafa Razavi, Maya Agarwal, Parvir Aujla, Sharareh Gholamin, Lawrence Recht, Gordon Li

Tenovin-6-mediated inhibition of SIRT1/2 induces apoptosis in acute lymphoblastic leukemia (ALL) cells and eliminates ALL stem/progenitor cells

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Yanli Jin, Qi Cao, Chun Chen, Xin Du, Bei Jin, Jingxuan Pan

Role of the splicing factor SRSF4 in cisplatin-induced modifications of pre-mRNA splicing and apoptosis

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Maude Gabriel, Yves Delforge, Adeline Deward, Yvette Habraken, Benoit Hennuy, Jacques Piette, Roscoe Klinck, Benoit Chabot, Alain Colige, Charles Lambert

In vitro and in vivo antiproliferative activity of metformin on stem-like cells isolated from spontaneous canine mammary carcinomas: translational implications for human tumors

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Federica Barbieri, Stefano Thellung, Alessandra Ratto, Elisa Carra, Valeria Marini, Carmen Fucile, Adriana Bajetto, Alessandra Pattarozzi, Roberto Würth, Monica Gatti, Chiara Campanella, Guendalina Vito, Francesca Mattioli, Aldo Pagano, Antonio Daga, Angelo Ferrari, Tullio Florio

HNF1B polymorphism influences the prognosis of endometrial cancer patients: a cohort study

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Vincenzo Dario Mandato, Enrico Farnetti, Federica Torricelli, Martino Abrate, Bruno Casali, Gino Ciarlini, Debora Pirillo, Maria Carolina Gelli, Davide Nicoli, Mario Grassi, Giovanni Battista LA Sala, Stefano Palomba

HPV-16 impairs the subcellular distribution and levels of expression of protein phosphatase 1γ in cervical malignancy

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Takayuki Seiki, Kazunori Nagasaka, Christian Kranjec, Kei Kawana, Daichi Maeda, Hiroe Nakamura, Ayumi Taguchi, Yoko Matsumoto, Takahide Arimoto, Osamu Wada-Hiraike, Katsutoshi Oda, Shunsuke Nakagawa, Tetsu Yano, Masashi Fukayama, Lawrence Banks, Yutaka Osuga, Tomoyuki Fujii

Changing the clinical course of glioma patients by preoperative motor mapping with navigated transcranial magnetic brain stimulation

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Sandro M Krieg, Nico Sollmann, Thomas Obermueller, Jamil Sabih, Lucia Bulubas, Chiara Negwer, Tobias Moser, Doris Droese, Tobias Boeckh-Behrens, Florian Ringel, Bernhard Meyer

Effect of liver transplantation in combined hepatocellular and cholangiocellular carcinoma: a case series

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Di Wu, Zhong-Yang Shen, Ya-Min Zhang, Jian Wang, Hong Zheng, Yong-Lin Deng, Cheng Pan

eCROPS-CA: a systematic approach toward effective and sustainable cancer prevention in rural China

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• Study protocol

Jing Chai, Xingrong Shen, Rui Feng, Jing Cheng, Yeji Chen, Zhengqiu Zha, Shangchun Jia, Han Liang, Ting Zhao, Rui Sha, Yong Shi, Kaichun Li, Debin Wang

Vascular dysfunction and increased metastasis of B16F10 melanomas in Shb deficient mice as compared with their wild type counterparts

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Guangxiang Zang, Karin Gustafsson, Maria Jamalpour, JongWook Hong, Guillem Genové, Michael Welsh

Predicting response to multidrug regimens in cancer patients using cell line experiments and regularised regression models

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Steffen Falgreen, Karen Dybkær, Ken H Young, Zijun Y Xu-Monette, Tarec C El-Galaly, Maria Bach Laursen, Julie S Bødker, Malene K Kjeldsen, Alexander Schmitz, Mette Nyegaard, Hans Erik Johnsen, Martin Bøgsted

Clinical outcomes of patients with advanced hepatocellular carcinoma treated with sorafenib: a retrospective study of routine clinical practice in multi-institutions

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Sae Hwan Lee, Il Han Song, Ran Noh, Ha Yan Kang, Suk Bae Kim, Soon Young Ko, Eoum Seok Lee, Seok Hyun Kim, Byung Seok Lee, An Na Kim, Hee Bok Chae, Hong Soo Kim, Tae Hee Lee, Young Woo Kang, Jae Dong Lee, Heon Young Lee

Treatment of advanced gastrointestinal tumors with genetically modified autologous mesenchymal stromal cells (TREAT-ME1): study protocol of a phase I/II clinical trial

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• Study protocol

Hanno Niess, Jobst C von Einem, Michael N Thomas, Marlies Michl, Martin K Angele, Ralf Huss, Christine Günther, Peter J Nelson, Christiane J Bruns, Volker Heinemann

MicroRNA-223 is a novel negative regulator of HSP90B1 in CLL

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Ana E Rodríguez-Vicente, Dalia Quwaider, Rocío Benito, Irena Misiewicz-Krzeminska, María Hernández-Sánchez, Alfonso García de Coca, Rosa Fisac, José-María Alonso, Carolina Zato, Juan Francisco de Paz, Juan Luis García, Ma Eugenia Sarasquete, José Ángel Hernández, Juan M Corchado, Marcos González, Norma C Gutiérrez, Jesús-María Hernández-Rivas

Aurora kinase B is important for antiestrogen resistant cell growth and a potential biomarker for tamoxifen resistant breast cancer

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Sarah L Larsen, Christina W Yde, Anne-Vibeke Laenkholm, Birgitte B Rasmussen, Anne Katrine Duun-Henriksen, Martin Bak, Anne E Lykkesfeldt, Tove Kirkegaard

HGUE-C-1 is an atypical and novel colon carcinoma cell line

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Silvina Grasso, Isabel Martínez-Lacaci, Víctor Manuel Barberá, Adela Castillejo, José Luis Soto, Javier Gallego-Plazas, Natividad López-Riquelme, Pilar García-Morales, Trinidad Mata-Balaguer, José Antonio Ferragut, Miguel Saceda

Control of the MYC-eIF4E axis plus mTOR inhibitor treatment in small cell lung cancer

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Masaru Matsumoto, Masahiro Seike, Rintaro Noro, Chie Soeno, Teppei Sugano, Susumu Takeuchi, Akihiko Miyanaga, Kazuhiro Kitamura, Kaoru Kubota, Akihiko Gemma

DNA copy number analysis of metastatic urothelial carcinoma with comparison to primary tumors

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Richard M Bambury, Ami S Bhatt, Markus Riester, Chandra Sekhar Pedamallu, Fujiko Duke, Joaquim Bellmunt, Edward C Stack, Lillian Werner, Rachel Park, Gopa Iyer, Massimo Loda, Philip W Kantoff, Franziska Michor, Matthew Meyerson, Jonathan E Rosenberg

General Practitioners and Breast Surgeons in France, Germany, Netherlands and the UK show variable breast cancer risk communication profiles

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Claire Julian-Reynier, Anne-Deborah Bouhnik, D Gareth Evans, Hilary Harris, Christi J van Asperen, Aad Tibben, Joerg Schmidtke, Irmgard Nippert

High expression of NQO1 is associated with poor prognosis in serous ovarian carcinoma

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Xuelian Cui, Lianhua Li, Guanghai Yan, Kai Meng, Zhenhua Lin, Yunze Nan, Guang Jin, Chunyu Li

TLR3 expression correlates with apoptosis, proliferation and angiogenesis in hepatocellular carcinoma and predicts prognosis

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Ming-Ming Yuan, Yu-Yin Xu, Li Chen, Xing-Yu Li, Jing Qin, Ying Shen

Serine threonine tyrosine kinase 1 is a potential prognostic marker in colorectal cancer

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Liang Hu, Hai-Yang Chen, Jian Cai, Yu Zhang, Chen-Ye Qi, Hui Gong, Yan-Xia Zhai, Hao Fu, Guang-Zhen Yang, Chun-Fang Gao

Oxaliplatin toxicity presenting as a liver nodule – case report

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• Case report

Henrique Alexandrino, Domingos Oliveira, Maria Augusta Cipriano, Luís Ferreira, J Guilherme Tralhão, Francisco Castro e Sousa

Oridonin stabilizes retinoic acid receptor alpha through ROS-activated NF-κB signaling

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Yang Cao, Wei Wei, Nan Zhang, Qing Yu, Wen-Bin Xu, Wen-Jun Yu, Guo-Qiang Chen, Ying-Li Wu, Hua Yan

Characteristics of attitude and recommendation of oncologists toward exercise in South Korea: a cross sectional survey study

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Ji-Hye Park, Minsuk Oh, Yong Jin Yoon, Chul Won Lee, Lee W Jones, Seung Il Kim, Nam Kyu Kim, Justin Y Jeon

Curcumin potentiates antitumor activity of 5-fluorouracil in a 3D alginate tumor microenvironment of colorectal cancer

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Mehdi Shakibaei, Patricia Kraehe, Bastian Popper, Parviz Shayan, Ajay Goel, Constanze Buhrmann

Combined comparative genomic hybridization and transcriptomic analyses of ovarian granulosa cell tumors point to novel candidate driver genes

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Sandrine Caburet, Mikko Anttonen, Anne-Laure Todeschini, Leila Unkila-Kallio, Denis Mestivier, Ralf Butzow, Reiner A Veitia

Confocal laser endomicroscopy in breast surgery: a pilot study

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Giovanni D De Palma, Dario Esposito, Gaetano Luglio, Gennaro Limite, Antonello Accurso, Viviana Sollazzo, Francesco Maione, Gianluca Cassese, Saverio Siciliano, Nicola Gennarelli, Gennaro Ilardi, Mariano Paternoster, Mariano C Giglio, Pietro Forestieri

Safety and feasibility of adjuvant chemotherapy with S-1 in Japanese breast cancer patients after primary systemic chemotherapy: a feasibility study

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Takashi Shigekawa, Akihiko Osaki, Hiroshi Sekine, Nobuaki Sato, Chizuko Kanbayashi, Hiroshi Sano, Hideki Takeuchi, Shigeto Ueda, Noriko Nakamiya, Ikuko Sugitani, Michiko Sugiyama, Hiroko Shimada, Eiko Hirokawa, Takao Takahashi, Toshiaki Saeki

The natural compound Guttiferone F sensitizes prostate cancer to starvation induced apoptosis via calcium and JNK elevation

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Xin Li, Yuanzhi Lao, Hong Zhang, Xiaoyu Wang, Hongsheng Tan, Zhixiu Lin, Hongxi Xu

Combined treatment of Nimotuzumab and rapamycin is effective against temozolomide-resistant human gliomas regardless of the EGFR mutation status

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Dawn Q Chong, Xin Y Toh, Ivy AW Ho, Kian C Sia, Jennifer P Newman, Yulyana Yulyana, Wai-Hoe Ng, Siang H Lai, Mac MF Ho, Nivedh Dinesh, Chee K Tham, Paula YP Lam

Remodeling of extracellular matrix by normal and tumor-associated fibroblasts promotes cervical cancer progression

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Alexandra Fullár, József Dudás, Lászlóné Oláh, Péter Hollósi, Zoltán Papp, Gábor Sobel, Katalin Karászi, Sándor Paku, Kornélia Baghy, Ilona Kovalszky

Long-term follow-up results of simultaneous integrated or late course accelerated boost with external beam radiotherapy to vaginal cuff for high risk cervical cancer patients after radical hysterectomy

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Xin Wang, Yaqin Zhao, Yali Shen, Pei Shu, Zhiping Li, Sen Bai, Feng Xu

A retrospective observational study of clinicopathological features of KRAS, NRAS, BRAF and PIK3CA mutations in Japanese patients with metastatic colorectal cancer

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Akihito Kawazoe, Kohei Shitara, Shota Fukuoka, Yasutoshi Kuboki, Hideaki Bando, Wataru Okamoto, Takashi Kojima, Nozomu Fuse, Takeharu Yamanaka, Toshihiko Doi, Atsushi Ohtsu, Takayuki Yoshino

Novel non-invasive biomarkers that distinguish between benign prostate hyperplasia and prostate cancer

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Andrej Jedinak, Adam Curatolo, David Zurakowski, Simon Dillon, Manoj K Bhasin, Towia A Libermann, Roopali Roy, Monisha Sachdev, Kevin R Loughlin, Marsha A Moses

Identification of a unique hepatocellular carcinoma line, Li-7, with CD13(+) cancer stem cells hierarchy and population change upon its differentiation during culture and effects of sorafenib

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Takeshi Yamada, Masato Abei, Inaho Danjoh, Ryoko Shirota, Taro Yamashita, Ichinosuke Hyodo, Yukio Nakamura

The impact of preoperative language mapping by repetitive navigated transcranial magnetic stimulation on the clinical course of brain tumor patients

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Nico Sollmann, Sebastian Ille, Theresa Hauck, Stefanie Maurer, Chiara Negwer, Claus Zimmer, Florian Ringel, Bernhard Meyer, Sandro M Krieg

Cyclin D1 sensitizes myeloma cells to endoplasmic reticulum stress-mediated apoptosis by activating the unfolded protein response pathway

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Sophie Bustany, Julie Cahu, Philippe Guardiola, Brigitte Sola

The role of clinically significant portal hypertension in hepatic resection for hepatocellular carcinoma patients: a propensity score matching analysis

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Wei He, Qingli Zeng, Yun Zheng, Meixian Chen, Jingxian Shen, Jiliang Qiu, Miao Chen, Ruhai Zou, Yadi Liao, Qijiong Li, Xianqiu Wu, Binkui Li, Yunfei Yuan

Copy number gain of granulin-epithelin precursor (GEP) at chromosome 17q21 associates with overexpression in human liver cancer

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Man Kuen Yung, Kwok Wai Lo, Chi Wai Yip, Grace TY Chung, Carol YK Tong, Phyllis FY Cheung, Tan To Cheung, Ronnie TP Poon, Samuel So, Sheung Tat Fan, Siu Tim Cheung

Feasibility of self-sampled dried blood spot and saliva samples sent by mail in a population-based study

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Amrit Kaur Sakhi, Nasser Ezzatkhah Bastani, Merete Ellingjord-Dale, Thomas Erik Gundersen, Rune Blomhoff, Giske Ursin

The involvement of insulin-like growth factor 2 binding protein 3 (IMP3) in pancreatic cancer cell migration, invasion, and adhesion

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Clarissa C Pasiliao, Che-Wei A Chang, Brent W Sutherland, Shannon M Valdez, David Schaeffer, Donald T Yapp, Sylvia S W Ng

Pro1170 Ala polymorphism in HER2-neu is associated with risk of trastuzumab cardiotoxicity

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Sasha E Stanton, Maureen M Ward, Paul Christos, Rachel Sanford, Christina Lam, Marta V Cobham, Diana Donovan, Ronald J Scheff, Tessa Cigler, Anne Moore, Linda T Vahdat, Maureen E Lane, Ellen Chuang

Perceived causes and consequences of sexual changes after cancer for women and men: a mixed method study

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Jane M Ussher, Janette Perz, Emilee Gilbert

Gangliocytic paraganglioma: a multi-institutional retrospective study in Japan

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Yoichiro Okubo, Tetsuo Nemoto, Megumi Wakayama, Naobumi Tochigi, Minoru Shinozaki, Takao Ishiwatari, Kyoko Aki, Masaru Tsuchiya, Hajime Aoyama, Kanade Katsura, Takeshi Fujii, Takashi Nishigami, Tomoyuki Yokose, Yasuo Ohkura, Kazutoshi Shibuya

Management and prognosis of patients with ovarian sex cord tumor with annular tubules: a retrospective study

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Qiuhong Qian, Yan You, Jiaxin Yang, Dongyan Cao, Zhaohui Zhu, Ming Wu, Jie Chen, Jinghe Lang, Keng Shen

Colorectal liver metastases: making the unresectable resectable using irreversible electroporation for microscopic positive margins – a case report

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• Case report

Hans F Schoellhammer, Bryan Goldner, Shaila J Merchant, Jonathan Kessler, Yuman Fong, Singh Gagandeep

Lower PRDM2 expression is associated with dopamine-agonist resistance and tumor recurrence in prolactinomas

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Hua Gao, Fei Wang, Xiaolei Lan, Chuzhong Li, Jie Feng, Jiwei Bai, Lei Cao, Songbai Gui, Lichuan Hong, Yazhuo Zhang

DNA methylation and histone modifications regulate SOX11 expression in lymphoid and solid cancer cells

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Lena Nordström, Elin Andersson, Venera Kuci, Elin Gustavsson, Karolina Holm, Markus Ringnér, Per Guldberg, Sara Ek

Inter-observer agreement according to three methods of evaluating mammographic density and parenchymal pattern in a case control study: impact on relative risk of breast cancer

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Rikke Rass Winkel, My von Euler-Chelpin, Mads Nielsen, Pengfei Diao, Michael Bachmann Nielsen, Wei Yao Uldall, Ilse Vejborg

Loss of AF-6/afadin induces cell invasion, suppresses the formation of glandular structures and might be a predictive marker of resistance to chemotherapy in endometrial cancer

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Takuro Yamamoto, Taisuke Mori, Morio Sawada, Hiroshi Matsushima, Fumitake Ito, Makoto Akiyama, Jo Kitawaki

Discovery and anti-cancer evaluation of two novel non-ATP-competitive FGFR1 inhibitors in non-small-cell lung cancer

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Jianzhang Wu, Tao Wei, Qinqin Tang, Bixia Weng, Wulan Li, Xin Jiang, Ting Ding, Xiaokun Li, Guang Liang, Yuepiao Cai, Jiansong Ji

ACTN4 and the pathways associated with cell motility and adhesion contribute to the process of lung cancer metastasis to the brain

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Yufei Gao, Guanghu Li, Liankun Sun, Yichun He, Xiaoyan Li, Zhi Sun, Jihan Wang, Yang Jiang, Jingwei Shi

Association of high obesity with PAM50 breast cancer intrinsic subtypes and gene expression

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Marilyn L Kwan, Candyce H Kroenke, Carol Sweeney, Philip S Bernard, Erin K Weltzien, Adrienne Castillo, Rachel E Factor, Kaylynn S Maxfield, Inge J Stijleman, Lawrence H Kushi, Charles P Quesenberry Jr., Laurel A Habel, Bette J Caan

The implementation of an organised cervical screening programme in Poland: an analysis of the adherence to European guidelines

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Andrzej Nowakowski, Marek Cybulski, Andrzej Śliwczyński, Arkadiusz Chil, Zbigniew Teter, Przemysław Seroczyński, Marc Arbyn, Ahti Anttila

Improving the assessment of quality of life in the clinical care of myeloma patients: the development and validation of the Myeloma Patient Outcome Scale (MyPOS)

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Thomas R Osborne, Christina Ramsenthaler, Stephen A Schey, Richard J Siegert, Polly M Edmonds, Irene J Higginson

Multiparametric MRI as an outcome predictor for anal canal cancer managed with chemoradiotherapy

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Michael Jones, George Hruby, Peter Stanwell, Sarah Gallagher, Karen Wong, Jameen Arm, Jarad Martin

Clinicopathological study of centrally necrotizing carcinoma of the breast

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Yanling Zhang, Yurong Ou, Donghong Yu, Xiang Yong, Xiaoli Wang, Bo Zhu, Qiong Zhang, Lei Zhou, Zhaogen Cai, Zenong Cheng

Impact of kinesin Eg5 inhibition by 3,4-dihydropyrimidin-2(1H)-one derivatives on various breast cancer cell features

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Bruna C Guido, Luciana M Ramos, Diego O Nolasco, Catharine C Nobrega, Bárbara YG Andrade, Aline Pic-Taylor, Brenno AD Neto, José R Corrêa

A new relative tumor sizing method in epi-metaphyseal osteosarcoma

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Seung Hyun Kim, Kyoo-Ho Shin, Eun Hae Park, Yong Jin Cho, Byoung-Kyu Park, Jin-Suck Suh, Woo-Ick Yang

Altered PPP2R2A and Cyclin D1 expression defines a subgroup of aggressive luminal-like breast cancer

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Francisco Beca, Miguel Pereira, Jorge F Cameselle-Teijeiro, Diana Martins, Fernando Schmitt

Epidemiological patterns of asbestos exposure and spatial clusters of incident cases of malignant mesothelioma from the Italian national registry

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Marisa Corfiati, Alberto Scarselli, Alessandra Binazzi, Davide Di Marzio, Marina Verardo, Dario Mirabelli, Valerio Gennaro, Carolina Mensi, Gert Schallemberg, Enzo Merler, Corrado Negro, Antonio Romanelli, Elisabetta Chellini, Stefano Silvestri, Mario Cocchioni, Cristiana Pascucci, Fabrizio Stracci, Elisa Romeo, Luana Trafficante, Italo Angelillo, Simona Menegozzo, Marina Musti, Domenica Cavone, Gabriella Cauzillo, Federico Tallarigo, Rosario Tumino, Massimo Melis, Sergio Iavicoli, Alessandro Marinaccio

The end of the decline in cervical cancer mortality in Spain: trends across the period 1981–2012

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Marta Cervantes-Amat, Gonzalo López-Abente, Nuria Aragonés, Marina Pollán, Roberto Pastor-Barriuso, Beatriz Pérez-Gómez

A longitudinal study of non-medical determinants of adherence to R-CHOP therapy for diffuse large B-cell lymphoma: implication for survival

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Cécile Borel, Sébastien Lamy, Gisèle Compaci, Christian Récher, Pauline Jeanneau, Jean Claude Nogaro, Eric Bauvin, Fabien Despas, Cyrille Delpierre, Guy Laurent

Which is the best method of sterilization for recycled bone autograft in limb salvage surgery: a radiological, biomechanical and histopathological study in rabbit

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Nor Faissal Yasin, Vivek Ajit Singh, Marniza Saad, Effat Omar

Platelets enhance tissue factor protein and metastasis initiating cell markers, and act as chemoattractants increasing the migration of ovarian cancer cells

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Renan Orellana, Sumie Kato, Rafaela Erices, María Loreto Bravo, Pamela Gonzalez, Bárbara Oliva, Sofía Cubillos, Andrés Valdivia, Carolina Ibañez, Jorge Brañes, María Isabel Barriga, Erasmo Bravo, Catalina Alonso, Eva Bustamente, Enrique Castellon, Patricia Hidalgo, Cesar Trigo, Olga Panes, Jaime Pereira, Diego Mezzano, Mauricio A Cuello, Gareth I Owen

Massively parallel sequencing fails to detect minor resistant subclones in tissue samples prior to tyrosine kinase inhibitor therapy

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Carina Heydt, Niklas Kumm, Jana Fassunke, Helen Künstlinger, Michaela Angelika Ihle, Andreas Scheel, Hans-Ulrich Schildhaus, Florian Haller, Reinhard Büttner, Margarete Odenthal, Eva Wardelmann, Sabine Merkelbach-Bruse

Apparent diffusion coefficient measurement by diffusion weighted magnetic resonance imaging is a useful tool in differentiating renal tumors

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Jing-Hong Liu, Shi-Feng Tian, Ye Ju, Ye Li, An-Liang Chen, Li-Hua Chen, Ai-Lian Liu

Overexpression of IL-15 promotes tumor destruction via NK1.1+ cells in a spontaneous breast cancer model

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Amy E Gillgrass, Marianne V Chew, Tamara Krneta, Ali A Ashkar

Body mass index and participation in organized mammographic screening: a prospective cohort study

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Sophie Sell Hellmann, Sisse Helle Njor, Elsebeth Lynge, My von Euler-Chelpin, Anja Olsen, Anne Tjønneland, Ilse Vejborg, Zorana Jovanovic Andersen

Protocol of a multi-centre randomised controlled trial of a web-based information intervention with nurse-delivered telephone support for haematological cancer patients and their support persons

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• Study protocol

Jamie Bryant, Rob Sanson-Fisher, William Stevenson, Rochelle Smits, Frans Henskens, Andrew Wei, Flora Tzelepis, Catherine D’Este, Christine Paul, Mariko Carey

Targeting connexin 43 with α–connexin carboxyl-terminal (ACT1) peptide enhances the activity of the targeted inhibitors, tamoxifen and lapatinib, in breast cancer: clinical implication for ACT1

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Christina L Grek, Joshua Matthew Rhett, Jaclynn S Bruce, Melissa A Abt, Gautam S Ghatnekar, Elizabeth S Yeh

Circulating miR-200c and miR-141 and outcomes in patients with breast cancer

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Silvia Antolín, Lourdes Calvo, Moisés Blanco-Calvo, María Paz Santiago, María José Lorenzo-Patiño, Mar Haz-Conde, Isabel Santamarina, Angélica Figueroa, Luis Miguel Antón-Aparicio, Manuel Valladares-Ayerbes

Epidemiology, clinical profile and treatment patterns of venous thromboembolism in cancer patients in Taiwan: a population-based study

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Tan-Wei Chew, Churn-Shiouh Gau, Yu-Wen Wen, Li-Jiuan Shen, C Daniel Mullins, Fei-Yuan Hsiao

A pilot study of bevacizumab combined with etoposide and cisplatin in breast cancer patients with leptomeningeal carcinomatosis

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Pei-Fang Wu, Ching-Hung Lin, Ching-Hua Kuo, Wei-Wu Chen, Dah-Cherng Yeh, Hsiao-Wei Liao, Shu-Min Huang, Ann-Lii Cheng, Yen-Shen Lu

SNAI2/SLUG and estrogen receptor mRNA expression are inversely correlated and prognostic of patient outcome in metastatic non-small cell lung cancer

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Akin Atmaca, Ralph W Wirtz, Dominique Werner, Kristina Steinmetz, Silke Claas, Wolfgang M Brueckl, Elke Jäger, Salah-Eddin Al-Batran

Cancerous inhibitor of protein phosphatase 2A (CIP2A) is an independent prognostic marker in wild-type KRAS metastatic colorectal cancer after colorectal liver metastasectomy

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Kuen-Feng Chen, Chueh-Chuan Yen, Jen-Kou Lin, Wei-Shone Chen, Shung-Haur Yang, Jeng-Kai Jiang, Yuan-Tzu Lan, Chun-Chi Lin, Hui-Chuan Yu, Hui-Mei Hsu, Wen-Ling Lin, Hao-Wei Teng

Screening and treatment of psychological distress in patients with metastatic colorectal cancer: study protocol of the TES trial

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• Study protocol

Claudia SEW Schuurhuizen, Annemarie MJ Braamse, Aartjan TF Beekman, Hanna Bomhof-Roordink, Judith E Bosmans, Pim Cuijpers, Adriaan W Hoogendoorn, Inge RHM Konings, Mecheline HM van der Linden, Elisabeth CW Neefjes, Henk MW Verheul, Joost Dekker

Everolimus in metastatic renal cell carcinoma after failure of initial anti–VEGF therapy: final results of a noninterventional study

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Lothar Bergmann, Ulrich Kube, Christian Doehn, Thomas Steiner, Peter J Goebell, Manfred Kindler, Edwin Herrmann, Jan Janssen, Steffen Weikert, Michael T Scheffler, Joerg Schmitz, Michael Albrecht, Michael Staehler

The impact of FGFR1 and FRS2α expression on sorafenib treatment in metastatic renal cell carcinoma

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Thai H Ho, Xian-De Liu, Yanqing Huang, Carla L Warneke, Marcella M Johnson, Anh Hoang, Pheroze Tamboli, Fen Wang, Eric Jonasch

Is maximum primary tumor diameter still a prognostic factor in patients with nasopharyngeal carcinoma treated using intensity-modulated radiotherapy?

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Yong Chen, Xue-Feng Hu, Yan Wang, Hai-Yang Chen, Lin Yang, Li-Zhi Liu, Chun-Yan Cui, Dong-Sheng Liu, Shao-Bo Liang

STAT3 is involved in miR-124-mediated suppressive effects on esophageal cancer cells

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Yan Cheng, Yang Li, Yuanyuan Nian, Dong Liu, Fei Dai, Jun Zhang

Mammographic microcalcifications and breast cancer tumorigenesis: a radiologic-pathologic analysis

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Madiha Naseem, Joshua Murray, John F Hilton, Jason Karamchandani, Derek Muradali, Hala Faragalla, Chanele Polenz, Dolly Han, David C Bell, Christine Brezden-Masley

Diagnostic intervals before and after implementation of cancer patient pathways – a GP survey and registry based comparison of three cohorts of cancer patients

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Henry Jensen, Marie Louise Tørring, Frede Olesen, Jens Overgaard, Morten Fenger-Grøn, Peter Vedsted

A microRNA profile associated with Opisthorchis viverrini-induced cholangiocarcinoma in tissue and plasma

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Jordan Plieskatt, Gabriel Rinaldi, Yanjun Feng, Jin Peng, Samantha Easley, Xinying Jia, Jeremy Potriquet, Chawalit Pairojkul, Vajarabhongsa Bhudhisawasdi, Banchob Sripa, Paul J Brindley, Jeffrey Bethony, Jason Mulvenna

Adult metanephric adenoma presumed to be all benign? A clinical perspective

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Gang Li, Yuhong Tang, Renya Zhang, Hualin Song, Shumin Zhang, Yuanjie Niu

Frequency and distribution of Notch mutations in tumor cell lines

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Anders Peter Mutvei, Erik Fredlund, Urban Lendahl

A phase II RCT and economic analysis of three exercise delivery methods in men with prostate cancer on androgen deprivation therapy

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• Study protocol

Shabbir MH Alibhai, Daniel Santa Mina, Paul Ritvo, Catherine Sabiston, Murray Krahn, George Tomlinson, Andrew Matthew, Roanne Segal, Padraig Warde, Sara Durbano, Meagan O’Neill, Nicole Culos-Reed

A model-based assessment of the cost–utility of strategies to identify Lynch syndrome in early-onset colorectal cancer patients

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Tristan Snowsill, Nicola Huxley, Martin Hoyle, Tracey Jones-Hughes, Helen Coelho, Chris Cooper, Ian Frayling, Chris Hyde

Association between epidermal growth factor gene +61A/G polymorphism and the risk of hepatocellular carcinoma: a meta-analysis based on 16 studies

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Guoping Jiang, Ke Yu, Lifang Shao, Xiaobo Yu, Chen Hu, Pei Qian, Haiyang Xie, Jinjun Li, Jie Zheng, Shusen Zheng

Organized breast screening improves reattendance compared to physician referral: a case control study

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Ilia Makedonov, Sumei Gu, Lawrence F Paszat

Local pelvic irradiation modulates Pharmacokinetics of 5-Fluorouracil in the plasma but not in the Lymphatic System

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Chen-Hsi Hsieh, Mei-Ling Hou, Li-Ying Wang, Hung-Chi Tai, Tung-Hu Tsai, Yu-Jen Chen

Therapeutic effect of intravesical administration of paclitaxel solubilized with poly(2-methacryloyloxyethyl phosphorylcholine-co-n-butyl methacrylate) in an orthotopic bladder cancer model

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Koetsu Tamura, Eiji Kikuchi, Tomohiro Konno, Kazuhiko Ishihara, Kazuhiro Matsumoto, Akira Miyajima, Mototsugu Oya

Management and prognosis of patients with brain metastasis from gestational trophoblastic neoplasia: a 24-year experience in Peking union medical college hospital

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Changji Xiao, Junjun Yang, Jing Zhao, Tong Ren, Fengzhi Feng, Xirun Wan, Yang Xiang

Identification of sample-specific regulations using integrative network level analysis

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Chengyu Liu, Riku Louhimo, Marko Laakso, Rainer Lehtonen, Sampsa Hautaniemi

Targeted next generation sequencing of RB1 gene for the molecular diagnosis of Retinoblastoma

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Bharanidharan Devarajan, Logambiga Prakash, Thirumalai Raj Kannan, Aloysius A Abraham, Usha Kim, Veerappan Muthukkaruppan, Ayyasamy Vanniarajan

Internet-based cognitive behavioral therapy for sexual dysfunctions in women treated for breast cancer: design of a multicenter, randomized controlled trial

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Susanna B Hummel, Jacques JDM van Lankveld, Hester SA Oldenburg, Daniela EE Hahn, Eva Broomans, Neil K Aaronson

Neoadjuvant chemoradiation therapy for resectable esophago-gastric adenocarcinoma: a meta-analysis of randomized clinical trials

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Tao Fu, Zhao-De Bu, Zi-Yu Li, Lian-Hai Zhang, Xiao-Jiang Wu, Ai-Wen Wu, Fei Shan, Xin Ji, Qiu-Shi Dong, Jia-Fu Ji

Correlation of Aurora-A expression with the effect of chemoradiation therapy on esophageal squamous cell carcinoma

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Kiyokazu Tamotsu, Hiroshi Okumura, Yasuto Uchikado, Yoshiaki Kita, Ken Sasaki, Itaru Omoto, Tetsuhiro Owaki, Takaaki Arigami, Yoshikazu Uenosono, Akihiro Nakajo, Yuko Kijima, Sumiya Ishigami, Shoji Natsugoe

Down-regulation of NF kappa B activation is an effective therapeutic modality in acquired platinum-resistant bladder cancer

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Yujiro Ito, Eiji Kikuchi, Nobuyuki Tanaka, Takeo Kosaka, Eriko Suzuki, Ryuichi Mizuno, Toshiaki Shinojima, Akira Miyajima, Kazuo Umezawa, Mototsugu Oya

DNA Polymerases as targets for gene therapy of hepatocellular carcinoma

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Hao Liu, Qun Wei, Jia Wang, Xiaoming Huang, Chunchun Li, Qiaoli Zheng, Jiang Cao, Zhenyu Jia

PKCα promotes the mesenchymal to amoeboid transition and increases cancer cell invasiveness

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Katarína Vaškovičová, Emilia Szabadosová, Vladimír Čermák, Aneta Gandalovičová, Lenka Kasalová, Daniel Rösel, Jan Brábek

Capecitabine and irinotecan with bevacizumab 2-weekly for metastatic colorectal cancer: the phase II AVAXIRI study

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Pilar Garcia-Alfonso, Manuel Chaves, Andrés Muñoz, Antonieta Salud, Maria García-Gonzalez, Cristina Grávalos, Bartomeu Massuti, Encarna González-Flores, Bernardo Queralt, Amelia López-Ladrón, Ferran Losa, Maria Jose Gómez, Amparo Oltra, Enrique Aranda

Finding My Way: protocol of a randomised controlled trial evaluating an internet self-help program for cancer-related distress

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Lisa Beatty, Emma Kemp, Tracey Wade, Bogda Koczwara

Circulating miRNAs miR-34a and miR-150 associated with colorectal cancer progression

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Sinéad T Aherne, Stephen F Madden, David J Hughes, Barbara Pardini, Alessio Naccarati, Miroslav Levy, Pavel Vodicka, Paul Neary, Paul Dowling, Martin Clynes

Retrospective evaluation of the incidental finding of 403 papillary thyroid microcarcinomas in 2466 patients undergoing thyroid surgery for presumed benign thyroid disease

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Nikola Slijepcevic, Vladan Zivaljevic, Jelena Marinkovic, Sandra Sipetic, Aleksandar Diklic, Ivan Paunovic

Effects of JWA, XRCC1 and BRCA1 mRNA expression on molecular staging for personalized therapy in patients with advanced esophageal squamous cell carcinoma

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Bin Wei, Qin Han, Lijuan Xu, Xiaohui Zhang, Jing Zhu, Li Wan, Yan Jin, Zhaoye Qian, Jingjing Wu, Yong Gao, Jianwei Zhou, Xiaofei Chen

High expression of Talin-1 is associated with poor prognosis in patients with nasopharyngeal carcinoma

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Ya-Fei Xu, Xian-Yue Ren, Ying-Qin Li, Qing-Mei He, Xin-Ran Tang, Ying Sun, Jian-Yong Shao, Wei-Hua Jia, Tie-Bang Kang, Mu-Sheng Zeng, Na Liu, Jun Ma

FGF9 from cancer-associated fibroblasts is a possible mediator of invasion and anti-apoptosis of gastric cancer cells

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Chao Sun, Hirokazu Fukui, Ken Hara, Xinxing Zhang, Yoshitaka Kitayama, Hirotsugu Eda, Toshihiko Tomita, Tadayuki Oshima, Shojiro Kikuchi, Jiro Watari, Mitsuru Sasako, Hiroto Miwa

Systematic review of model-based cervical screening evaluations

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Diana Mendes, Iren Bains, Tazio Vanni, Mark Jit

Transient elevation of glycolysis confers radio-resistance by facilitating DNA repair in cells

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Anant Narayan Bhatt, Ankit Chauhan, Suchit Khanna, Yogesh Rai, Saurabh Singh, Ravi Soni, Namita Kalra, Bilikere S Dwarakanath

Determinants of gastric cancer screening attendance in Korea: a multi-level analysis

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Yunryong Chang, Belong Cho, Ki Young Son, Dong Wook Shin, Hosung Shin, Hyung-Kook Yang, Aesun Shin, Keun-Young Yoo

Transcriptional implications of intragenic DNA methylation in the oestrogen receptor alpha gene in breast cancer cells and tissues

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Natalie S Shenker, Kirsty J Flower, Charlotte S Wilhelm-Benartzi, Wei Dai, Emma Bell, Edmund Gore, Mona El Bahrawy, Gillian Weaver, Robert Brown, James M Flanagan

Nomogram for overall survival of Japanese patients with bone-metastatic prostate cancer

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Yasuhide Miyoshi, Kazumi Noguchi, Masahiro Yanagisawa, Masataka Taguri, Satoshi Morita, Ichiro Ikeda, Kiyoshi Fujinami, Takeshi Miura, Kazuki Kobayashi, Hiroji Uemura

Phase II study of axitinib with doublet chemotherapy in patients with advanced squamous non–small-cell lung cancer

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Igor M Bondarenko, Antonella Ingrosso, Paul Bycott, Sinil Kim, Cristina L Cebotaru

Colorectal carcinomas with KRAS codon 12 mutation are associated with more advanced tumor stages

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Wenbin Li, Tian Qiu, Wenxue Zhi, Susheng Shi, Shuangmei Zou, Yun Ling, Ling Shan, Jianming Ying, Ning Lu

Early diagnostic value of Bcl-3 localization in colorectal cancer

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Karunakar Saamarthy, Sofie Björner, Martin Johansson, Göran Landberg, Ramin Massoumi, Karin Jirström, Katarzyna Chmielarska Masoumi

Wilms’ tumor gene 1 regulates p63 and promotes cell proliferation in squamous cell carcinoma of the head and neck

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Xingru Li, Sofia Ottosson, Sihan Wang, Emma Jernberg, Linda Boldrup, Xiaolian Gu, Karin Nylander, Aihong Li

MTA2 enhances colony formation and tumor growth of gastric cancer cells through IL-11

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Chenfei Zhou, Jun Ji, Qu Cai, Min Shi, Xuehua Chen, Yingyan Yu, Zhenggang Zhu, Jun Zhang

Risk factors and clinical outcomes of acute myeloid leukaemia with central nervous system involvement in adults

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Chieh-Lung Cheng, Chi-Cheng Li, Hsin-An Hou, Wei-Quan Fang, Chin-Hao Chang, Chien-Ting Lin, Jih-Luh Tang, Wen-Chien Chou, Chien-Yuan Chen, Ming Yao, Shang-Yi Huang, Bor-Sheng Ko, Shang-Ju Wu, Woei Tsay, Hwei-Fang Tien

MicroRNA-10a is reduced in breast cancer and regulated in part through retinoic acid

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Sonja Khan, Deirdre Wall, Catherine Curran, John Newell, Michael J Kerin, Roisin M Dwyer

Nonsense and missense mutation of mitochondrial ND6 gene promotes cell migration and invasion in human lung adenocarcinoma

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Yang Yuan, Weixing Wang, Huizhong Li, Yongwei Yu, Jin Tao, Shengdong Huang, Zhiyong Zeng

The pretreatment albumin to globulin ratio predicts chemotherapeutic outcomes in patients with unresectable metastatic colorectal cancer

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Masatsune Shibutani, Kiyoshi Maeda, Hisashi Nagahara, Hiroshi Ohtani, Yasuhito Iseki, Tetsuro Ikeya, Kenji Sugano, Kosei Hirakawa

The emerging outcome of postoperative radiotherapy for stage IIIA(N2) non-small cell lung cancer patients: based on the three-dimensional conformal radiotherapy technique and institutional standard clinical target volume

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Wen Feng, Qin Zhang, Xiao-Long Fu, Xu-Wei Cai, Zheng-Fei Zhu, Huan-Jun Yang, Jia-Qing Xiang, Ya-Wei Zhang, Hai-Quan Chen

Clusterin transcript variants expression in thyroid tumor: a potential marker of malignancy?

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Paolo Fuzio, Anna Napoli, Anna Ciampolillo, Serafina Lattarulo, Angela Pezzolla, Nicoletta Nuzziello, Sabino Liuni, Francesco Giorgino, Eugenio Maiorano, Elda Perlino

A novel inflammation-based prognostic score in esophageal squamous cell carcinoma: the C-reactive protein/albumin ratio

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Xiao-li Wei, Feng-hua Wang, Dong-sheng Zhang, Miao-zhen Qiu, Chao Ren, Ying Jin, Yi-xin Zhou, De-shen Wang, Ming-ming He, Long Bai, Feng Wang, Hui-yan Luo, Yu-hong Li, Rui-hua Xu

Cytotoxicity and infiltration of human NK cells in in vivo-like tumor spheroids

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• Technical advance

Ariane Giannattasio, Sandra Weil, Stephan Kloess, Nariman Ansari, Ernst H K Stelzer, Adelheid Cerwenka, Alexander Steinle, Ulrike Koehl, Joachim Koch

Proteoglycan-based diversification of disease outcome in head and neck cancer patients identifies NG2/CSPG4 and syndecan-2 as unique relapse and overall survival predicting factors

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Anna Farnedi, Silvia Rossi, Nicoletta Bertani, Mariolina Gulli, Enrico Maria Silini, Maria Teresa Mucignat, Tito Poli, Enrico Sesenna, Davide Lanfranco, Lucio Montebugnoli, Elisa Leonardi, Claudio Marchetti, Renato Cocchi, Andrea Ambrosini-Spaltro, Maria Pia Foschini, Roberto Perris

Randomized phase III trial of radiotherapy or chemoradiotherapy with topotecan and cisplatin in intermediate-risk cervical cancer patients after radical hysterectomy

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Wenze Sun, Tao Wang, Fan Shi, Jiquan Wang, Juan Wang, Beina Hui, Yingbing Zhang, Jinli Lu, Hongwei Chen, Zi Liu

Healthcare costs attributable to the treatment of patients with spinal metastases: a cohort study with up to 8 years follow-up

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Line Stjernholm Tipsmark, Cody Eric Bünger, Miao Wang, Søren Schmidt Morgen, Benny Dahl, Rikke Søgaard

Efficacy of laparoscopic subtotal gastrectomy with D2 lymphadenectomy for locally advanced gastric cancer: the protocol of the KLASS-02 multicenter randomized controlled clinical trial

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• Study protocol

Hoon Hur, Hyun Yong Lee, Hyuk-Joon Lee, Min Chan Kim, Woo Jin Hyung, Young Kyu Park, Wook Kim, Sang-Uk Han

Inhibition of colony stimulating factor-1 receptor improves antitumor efficacy of BRAF inhibition

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Stephen Mok, Jennifer Tsoi, Richard C Koya, Siwen Hu-Lieskovan, Brian L West, Gideon Bollag, Thomas G Graeber, Antoni Ribas

ZFP36 stabilizes RIP1 via degradation of XIAP and cIAP2 thereby promoting ripoptosome assembly

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Tommaso Selmi, Claudia Alecci, Miriam dell’ Aquila, Lucia Montorsi, Andrea Martello, Filippo Guizzetti, Nicola Volpi, Sandra Parenti, Sergio Ferrari, Paolo Salomoni, Alexis Grande, Tommaso Zanocco-Marani

Mechanism study of peptide GMBP1 and its receptor GRP78 in modulating gastric cancer MDR by iTRAQ-based proteomic analysis

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Xiaojuan Wang, Yani Li, Guanghui Xu, Muhan Liu, Lin Xue, Lijuan Liu, Sijun Hu, Ying Zhang, Yongzhan Nie, Shuhui Liang, Biaoluo Wang, Jie Ding

Metronomic oral vinorelbine as first-line treatment in elderly patients with advanced non-small cell lung cancer: results of a phase II trial (MOVE trial)

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Andrea Camerini, Cheti Puccetti, Sara Donati, Chiara Valsuani, Maria Cristina Petrella, Gianna Tartarelli, Paolo Puccinelli, Domenico Amoroso

High-recovery visual identification and single-cell retrieval of circulating tumor cells for genomic analysis using a dual-technology platform integrated with automated immunofluorescence staining

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• Technical advance

Daniel E Campton, Arturo B Ramirez, Joshua J Nordberg, Nick Drovetto, Alisa C Clein, Paulina Varshavskaya, Barry H Friemel, Steve Quarre, Amy Breman, Michael Dorschner, Sibel Blau, C Anthony Blau, Daniel E Sabath, Jackie L Stilwell, Eric P Kaldjian

Chromosomal instability as a prognostic marker in cervical cancer

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Christine How, Jeff Bruce, Jonathan So, Melania Pintilie, Benjamin Haibe-Kains, Angela Hui, Blaise A Clarke, David W Hedley, Richard P Hill, Michael Milosevic, Anthony Fyles, Fei-Fei Liu

HBx induced AFP receptor expressed to activate PI3K/AKT signal to promote expression of Src in liver cells and hepatoma cells

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Mingyue Zhu, Junli Guo, Wei Li, Hua Xia, Yan Lu, Xu Dong, Yi Chen, Xieju Xie, Shigan Fu, Mengsen Li

Prognostic model for long-term survival of locally advanced non-small-cell lung cancer patients after neoadjuvant radiochemotherapy and resection integrating clinical and histopathologic factors

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Christoph Pöttgen, Martin Stuschke, Britta Graupner, Dirk Theegarten, Thomas Gauler, Verena Jendrossek, Lutz Freitag, Jehad Abu Jawad, Eleni Gkika, Jeremias Wohlschlaeger, Stefan Welter, Matthias Hoiczyk, Martin Schuler, Georgios Stamatis, Wilfried Eberhardt

Utility of SAM68 in the progression and prognosis for bladder cancer

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Zhiling Zhang, Chunping Yu, Yonghong Li, Lijuan Jiang, Fangjian Zhou

Treatment strategies in colorectal cancer patients with initially unresectable liver-only metastases, a study protocol of the randomised phase 3 CAIRO5 study of the Dutch Colorectal Cancer Group (DCCG)

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• Study protocol

Joost Huiskens, Thomas M van Gulik, Krijn P van Lienden, Marc RW Engelbrecht, Gerrit A Meijer, Nicole CT van Grieken, Jonne Schriek, Astrid Keijser, Linda Mol, I Quintus Molenaar, Cornelis Verhoef, Koert P de Jong, Kees HC Dejong, Geert Kazemier, Theo M Ruers, Johanus HW de Wilt, Harm van Tinteren, Cornelis JA Punt

The prevention, detection and management of cancer treatment-induced cardiotoxicity: a meta-review

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Aaron Conway, Alexandra L McCarthy, Petra Lawrence, Robyn A Clark

Plasma membrane proteomic analysis of human Gastric Cancer tissues: revealing flotillin 1 as a marker for Gastric Cancer

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Wen Gao, Jing Xu, Fuqiang Wang, Long Zhang, Rui Peng, Yongqian Shu, Jindao Wu, Qiyun Tang, Yunxia Zhu

URG4/URGCP enhances the angiogenic capacity of human hepatocellular carcinoma cells in vitro via activation of the NF-κB signaling pathway

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Sizhong Xing, Bing Zhang, Ruixi Hua, William Chi-shing Tai, Zhirong Zeng, Binhui Xie, Chenghui Huang, Jisu Xue, Shiqiu Xiong, Jianyong Yang, Side Liu, Heping Li

Transcriptional changes associated with resistance to inhibitors of epidermal growth factor receptor revealed using metaanalysis

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Sidra Younis, Qamar Javed, Miroslav Blumenberg

The prognostic significance of lymphovascular invasion in patients with resectable gastric cancer: a large retrospective study from Southern China

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Peng Li, Hao-Qiang He, Chong-Mei Zhu, Yi-Hong Ling, Wan-Ming Hu, Xin-Ke Zhang, Rong-Zhen Luo, Jing-Ping Yun, Dan Xie, Yuan-Fang Li, Mu-Yan Cai

Pain, PSA flare, and bone scan response in a patient with metastatic castration-resistant prostate cancer treated with radium-223, a case report

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• Case report

Megan A McNamara, Daniel J George

Soluble EpCAM levels in ascites correlate with positive cytology and neutralize catumaxomab activity in vitro

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Andreas Seeber, Agnieszka Martowicz, Gilbert Spizzo, Thomas Buratti, Peter Obrist, Dominic Fong, Guenther Gastl, Gerold Untergasser

Reducing tumor growth and angiogenesis using a triple therapy measured with Contrast-enhanced ultrasound (CEUS)

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Philipp Marius Paprottka, Svenja Roßpunt, Michael Ingrisch, Clemens C Cyran, Konstantin Nikolaou, Maximilian F Reiser, Brigitte Mack, Olivier Gires, Dirk A Clevert, Pamela Zengel

The combination of sorafenib and everolimus shows antitumor activity in preclinical models of malignant pleural mesothelioma

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Ymera Pignochino, Carmine Dell’Aglio, Simona Inghilleri, Michele Zorzetto, Marco Basiricò, Federica Capozzi, Marta Canta, Davide Piloni, Francesca Cemmi, Dario Sangiolo, Loretta Gammaitoni, Marco Soster, Serena Marchiò, Ernesto Pozzi, Patrizia Morbini, Maurizio Luisetti, Massimo Aglietta, Giovanni Grignani, Giulia M Stella

Transcriptional profiling provides insights into metronomic cyclophosphamide-activated, innate immune-dependent regression of brain tumor xenografts

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Joshua C Doloff, David J Waxman

Mesothelioma patient derived tumor xenografts with defined BAP1 mutations that mimic the molecular characteristics of human malignant mesothelioma

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Neetu Kalra, Jingli Zhang, Anish Thomas, Liqiang Xi, Mitchell Cheung, Jacqueline Talarchek, Sandra Burkett, Maria G Tsokos, Yuanbin Chen, Mark Raffeld, Markku Miettinen, Ira Pastan, Joseph R Testa, Raffit Hassan

The prognostic value of EGFR overexpression and amplification in Esophageal squamous cell Carcinoma

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Dongxian Jiang, Xiaojing Li, Haixing Wang, Yuan Shi, Chen Xu, Shaohua Lu, Jie Huang, Yifan Xu, Haiying Zeng, Jieakesu Su, Yingyong Hou, Lijie Tan

Feasibility of a multimodal 18F-FDG-directed lymph node surgical excisional biopsy approach for appropriate diagnostic tissue sampling in patients with suspected lymphoma

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Stephen P Povoski, Nathan C Hall, Douglas A Murrey Jr, Chadwick L Wright, Edward W Martin Jr

Prognostic value of tumor suppressors in osteosarcoma before and after neoadjuvant chemotherapy

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Bernhard Robl, Chantal Pauli, Sander Martijn Botter, Beata Bode-Lesniewska, Bruno Fuchs

High expression of KPNA2 defines poor prognosis in patients with upper tract urothelial carcinoma treated with radical nephroureterectomy

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• Research article

Bentao Shi, Boxing Su, Dong Fang, Yuan Tang, Gengyan Xiong, Zhongqiang Guo, Qun He, Xinyu Yang, Wei Zhao, Yinglu Guo, Xuesong Li, Liqun Zhou

Significance of KRAS/PAK1/Crk pathway in non-small cell lung cancer oncogenesis

• Open Access
• Research article

Fariborz Mortazavi, Jie Lu, Ryan Phan, Michael Lewis, Kenny Trinidad, Amir Aljilani, Gholamhossein Pezeshkpour, Fuyuhiko Tamanoi

Improved false negative rate of axillary status using sentinel lymph node biopsy and ultrasound-suspicious lymph node sampling in patients with early breast cancer

• Open Access
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Yulong Wang, Haiyan Dong, Hongyan Wu, Li Zhang, Kai Yuan, Hongqiang Chen, Mingwen Jiao, Rongzhan Fu

Genome-wide association study of susceptibility loci for breast cancer in Sardinian population

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• Research article

Grazia Palomba, Angela Loi, Eleonora Porcu, Antonio Cossu, Ilenia Zara, Mario Budroni, Mariano Dei, Sandra Lai, Antonella Mulas, Nina Olmeo, Maria Teresa Ionta, Francesco Atzori, Gianmauro Cuccuru, Maristella Pitzalis, Magdalena Zoledziewska, Nazario Olla, Mario Lovicu, Marina Pisano, Gonçalo R. Abecasis, Manuela Uda, Francesco Tanda, Kyriaki Michailidou, Douglas F. Easton, Stephen J. Chanock, Robert N. Hoover, David J. Hunter, David Schlessinger, Serena Sanna, Laura Crisponi, Giuseppe Palmieri

Randomized phase III clinical trial comparing the combination of capecitabine and oxaliplatin (CAPOX) with the combination of 5-fluorouracil, leucovorin and oxaliplatin (modified FOLFOX6) as adjuvant therapy in patients with operated high-risk stage II or stage III colorectal cancer

• Open Access
• Research article

Dimitrios Pectasides, Vasilios Karavasilis, George Papaxoinis, Georgia Gourgioti, Thomas Makatsoris, Georgia Raptou, Eleni Vrettou, Joseph Sgouros, Epaminontas Samantas, George Basdanis, Pavlos Papakostas, Dimitrios Bafaloukos, Vassiliki Kotoula, Haralambos P. Kalofonos, Chrisoula D. Scopa, George Pentheroudakis, George Fountzilas

Dysregulated cholinergic network as a novel biomarker of poor prognostic in patients with head and neck squamous cell carcinoma

• Open Access
• Research article

Ana Cristina Castillo-González, Susana Nieto-Cerón, Juan Pablo Pelegrín-Hernández, María Fernanda Montenegro, José Antonio Noguera, María Fuensanta López-Moreno, José Neptuno Rodríguez-López, Cecilio J Vidal, Diego Hellín-Meseguer, Juan Cabezas-Herrera

The relationship between glasgow prognostic score and serum tumor markers in patients with advanced non-small cell lung cancer

• Open Access
• Research article

Ai-Gui Jiang, Hong-Lin Chen, Hui-Yu Lu

Optimisation of immunofluorescence methods to determine MCT1 and MCT4 expression in circulating tumour cells

• Open Access
• Technical advance

Stephen Kershaw, Jeffrey Cummings, Karen Morris, Jonathan Tugwood, Caroline Dive

Hospital discharges for fever and neutropenia in pediatric cancer patients: United States, 2009

• Open Access
• Research article

Emily L. Mueller, Kelly J. Walkovich, Rajen Mody, Achamyeleh Gebremariam, Matthew M. Davis

The role of c-Src in the invasion and metastasis of hepatocellular carcinoma cells induced by association of cell surface GRP78 with activated α2M

• Open Access
• Research article

Song Zhao, Hongdan Li, Qingjun Wang, Chang Su, Guan Wang, Huijuan Song, Liang Zhao, Zhidong Luan, Rongjian Su

Mitogen- and stress-activated Kinase 1 mediates Epstein-Barr virus latent membrane protein 1-promoted cell transformation in nasopharyngeal carcinoma through its induction of Fra-1 and c-Jun genes

• Open Access
• Research article

Binbin Li, Zheng Wan, Guoliang Huang, Zunnan Huang, Xiangning Zhang, Dan Liao, Shengqun Luo, Zhiwei He

NBPF1, a tumor suppressor candidate in neuroblastoma, exerts growth inhibitory effects by inducing a G1 cell cycle arrest

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Vanessa Andries, Karl Vandepoele, Katrien Staes, Geert Berx, Pieter Bogaert, Gert Van Isterdael, Daisy Ginneberge, Eef Parthoens, Jonathan Vandenbussche, Kris Gevaert, Frans van Roy

Impact of neo-adjuvant Sorafenib treatment on liver transplantation in HCC patients - a prospective, randomized, double-blind, phase III trial

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Katrin Hoffmann, Tom Ganten, Daniel Gotthardtp, Boris Radeleff, Utz Settmacher, Otto Kollmar, Silvio Nadalin, Irini Karapanagiotou-Schenkel, Christof von Kalle, Dirk Jäger, Markus W Büchler, Peter Schemmer

Increased risk of second primary malignancies following uterine cancer: a population-based study in Taiwan over a 30-year period

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• Research article

Kuan-Der Lee, Chao-Yu Chen, Huei-Jean Huang, Ting-Yao Wang, David Teng, Shih-Hao Huang, Chyong-Huey Lai, Min-Chi Chen

The patient-breast cancer care pathway: how could it be optimized?

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• Study protocol

Sandrine Baffert, Huong Ly Hoang, Anne Brédart, Bernard Asselain, Séverine Alran, Hélène Berseneff, Cyrille Huchon, Caroline Trichot, Aline Combes, Karine Alves, Martin Koskas, Thuy Nguyen, Aurélie Roulot, Roman Rouzier, Delphine Héquet

Phase I/II study of temsirolimus for patients with unresectable Hepatocellular Carcinoma (HCC)- a correlative study to explore potential biomarkers for response

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Winnie Yeo, Stephen L Chan, Frankie KF Mo, Cheuk M Chu, Joyce WY Hui, Joanne HM Tong, Anthony WH Chan, Jane Koh, Edwin P Hui, Herbert Loong, Kirsty Lee, Leung Li, Brigette Ma, Ka F To, Simon CH Yu

Preoperative serum CA125: a useful marker for surgical management of endometrial cancer

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• Research article

Tao Jiang, Ling Huang, Shulan Zhang

A male patient with acromegaly and breast cancer: treating acromegaly to control tumor progression

• Open Access
• Case report

Paola Leporati, Rodolfo Fonte, Luca de Martinis, Alberto Zambelli, Flavia Magri, Lorenzo Pavesi, Mario Rotondi, Luca Chiovato

Hyperemesis gravidarum and risk of cancer in offspring, a Scandinavian registry-based nested case–control study

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• Research article

Kathrine F. Vandraas, Åse V. Vikanes, Nathalie C. Støer, Rebecca Troisi, Olof Stephansson, Henrik T. Sørensen, Siri Vangen, Per Magnus, Andrej M. Grjibovski, Tom Grotmol

Variable expression levels of keratin and vimentin reveal differential EMT status of circulating tumor cells and correlation with clinical characteristics and outcome of patients with metastatic breast cancer

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• Research article

Hara Polioudaki, Sofia Agelaki, Rena Chiotaki, Eleni Politaki, Dimitris Mavroudis, Alexios Matikas, Vassilis Georgoulias, Panayiotis A Theodoropoulos

Prolonged survival of a patient with metastatic leptomeningeal melanoma treated with BRAF inhibition-based therapy: a case report

• Open Access
• Case report

Dae Won Kim, Edelyn Barcena, Urvi N Mehta, Michelle L Rohlfs, Ashok J Kumar, Marta Penas-Prado, Kevin B Kim

Mitochondrially targeted vitamin E succinate efficiently kills breast tumour-initiating cells in a complex II-dependent manner

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• Research article

Bing Yan, Marina Stantic, Renata Zobalova, Ayenachew Bezawork-Geleta, Michael Stapelberg, Jan Stursa, Katerina Prokopova, Lanfeng Dong, Jiri Neuzil

Pazopanib for metastatic pulmonary epithelioid hemangioendothelioma—a suitable treatment option: case report and review of anti-angiogenic treatment options

• Open Access
• Case report

Valeriya Semenisty, Inna Naroditsky, Zohar Keidar, Gil Bar-Sela

The impact of HER2 phenotype of circulating tumor cells in metastatic breast cancer: a retrospective study in 107 patients

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Markus Wallwiener, Andreas Daniel Hartkopf, Sabine Riethdorf, Juliane Nees, Martin Ronald Sprick, Birgitt Schönfisch, Florin-Andrei Taran, Jörg Heil, Christof Sohn, Klaus Pantel, Andreas Trumpp, Andreas Schneeweiss

Identification of novel drugs to target dormant micrometastases

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Robert E. Hurst, Paul J. Hauser, Youngjae You, Lora C. Bailey-Downs, Anja Bastian, Stephen M. Matthews, Jessica Thorpe, Christine Earle, Lilly Y. W. Bourguignon, Michael A. Ihnat

Opportunistic mammography screening provides effective detection rates in a limited resource healthcare system

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Yew-Ching Teh, Gie-Hooi Tan, Nur Aishah Taib, Kartini Rahmat, Caroline Judy Westerhout, Farhana Fadzli, Mee-Hoong See, Suniza Jamaris, Cheng-Har Yip

Clinical characteristics of narrow-band imaging of oral erythroplakia and its correlation with pathology

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Shih-Wei Yang, Yun-Shien Lee, Liang-Che Chang, Cheng-Cheng Hwang, Cheng-Ming Luo, Tai-An Chen

Autoantibodies in breast cancer sera are not epiphenomena and may participate in carcinogenesis

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Félix Fernández Madrid, Marie-Claire Maroun, Ofelia A Olivero, Michael Long, Azadeh Stark, Lawrence I Grossman, Walter Binder, Jingsheng Dong, Matthew Burke, S David Nathanson, Richard Zarbo, Dhananjay Chitale, Rocío Zeballos-Chávez, Carol Peebles

Early detection of breast cancer using total biochemical analysis of peripheral blood components: a preliminary study

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Udi Zelig, Eyal Barlev, Omri Bar, Itai Gross, Felix Flomen, Shaul Mordechai, Joseph Kapelushnik, Ilana Nathan, Hanoch Kashtan, Nir Wasserberg, Osnat Madhala-Givon

Fractal analysis of nuclear histology integrates tumor and stromal features into a single prognostic factor of the oral cancer microenvironment

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Pinaki Bose, Nigel T Brockton, Kelly Guggisberg, Steven C Nakoneshny, Elizabeth Kornaga, Alexander C Klimowicz, Mauro Tambasco, Joseph C Dort

Radiographers supporting radiologists in the interpretation of screening mammography: a viable strategy to meet the shortage in the number of radiologists

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Gabriela Torres-Mejía, Robert A. Smith, María de la Luz Carranza-Flores, Andy Bogart, Louis Martínez-Matsushita, Diana L. Miglioretti, Karla Kerlikowske, Carolina Ortega-Olvera, Ernesto Montemayor-Varela, Angélica Angeles-Llerenas, Sergio Bautista-Arredondo, Gilberto Sánchez-González, Olga G. Martínez-Montañez, Santos R. Uscanga-Sánchez, Eduardo Lazcano-Ponce, Mauricio Hernández-Ávila

The glutamate transport inhibitor DL-Threo-β-Benzyloxyaspartic acid (DL-TBOA) differentially affects SN38- and oxaliplatin-induced death of drug-resistant colorectal cancer cells

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Elena Pedraz-Cuesta, Sandra Christensen, Anders A. Jensen, Niels Frank Jensen, Lennart Bunch, Maria Unni Romer, Nils Brünner, Jan Stenvang, Stine Falsig Pedersen

The loss in expectation of life after colon cancer: a population-based study

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Therese M-L Andersson, Paul W. Dickman, Sandra Eloranta, Annika Sjövall, Mats Lambe, Paul C. Lambert

Oncology patients overwhelmingly support tissue banking

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Jamie Bryant, Rob Sanson-Fisher, Elizabeth Fradgley, Timothy Regan, Breanne Hobden, Stephen P. Ackland

Impact of cancer and chemotherapy on autonomic nervous system function and cardiovascular reactivity in young adults with cancer: a case-controlled feasibility study

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Scott C. Adams, Ronald Schondorf, Julie Benoit, Robert D. Kilgour

Targeted deep sequencing of mucinous ovarian tumors reveals multiple overlapping RAS-pathway activating mutations in borderline and cancerous neoplasms

• Open Access
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Robertson Mackenzie, Stefan Kommoss, Boris J. Winterhoff, Benjamin R. Kipp, Joaquin J. Garcia, Jesse Voss, Kevin Halling, Anthony Karnezis, Janine Senz, Winnie Yang, Elena-Sophie Prigge, Miriam Reuschenbach, Magnus Von Knebel Doeberitz, Blake C. Gilks, David G. Huntsman, Jamie Bakkum-Gamez, Jessica N. McAlpine, Michael S. Anglesio

Self-management support intervention to control cancer pain in the outpatient setting: a randomized controlled trial study protocol

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• Study protocol

Laura MJ Hochstenbach, Annemie M Courtens, Sandra MG Zwakhalen, Maarten van Kleef, Luc P de Witte

A seven-gene CpG-island methylation panel predicts breast cancer progression

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Yan Li, Anatoliy A. Melnikov, Victor Levenson, Emanuela Guerra, Pasquale Simeone, Saverio Alberti, Youping Deng

Concordance analysis of methylation biomarkers detection in self-collected and physician-collected samples in cervical neoplasm

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Cheng-Chang Chang, Rui-Lan Huang, Yu-Ping Liao, Po-Hsuan Su, Yaw-Wen Hsu, Hui-Chen Wang, Chau-Yang Tien, Mu-Hsien Yu, Ya-Wen Lin, Hung-Cheng Lai

Benefit of adjuvant chemotherapy in patients with T4 UICC II colon cancer

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Andreas Teufel, Michael Gerken, Janine Hartl, Timo Itzel, Stefan Fichtner-Feigl, Christian Stroszczynski, Hans Jürgen Schlitt, Ferdinand Hofstädter, Monika Klinkhammer-Schalke

Risk factors of PSA progression and overall survival in patients with localized and locally advanced prostate cancer treated with primary androgen deprivation therapy

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Atsushi Tomioka, Nobumichi Tanaka, Motokiyo Yoshikawa, Makito Miyake, Satoshi Anai, Yoshitomo Chihara, Eijiro Okajima, Akihide Hirayama, Yoshihiko Hirao, Kiyohide Fujimoto

The Danish cancer pathway for patients with serious non-specific symptoms and signs of cancer–a cross-sectional study of patient characteristics and cancer probability

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Mads Lind Ingeman, Morten Bondo Christensen, Flemming Bro, Søren T. Knudsen, Peter Vedsted

Enhancement of hypoxia-activated prodrug TH-302 anti-tumor activity by Chk1 inhibition

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Fanying Meng, Deepthi Bhupathi, Jessica D Sun, Qian Liu, Dharmendra Ahluwalia, Yan Wang, Mark D Matteucci, Charles P Hart

Pegylated liposomal doxorubicin (Lipo-Dox®) combined with cyclophosphamide and 5-fluorouracil is effective and safe as salvage chemotherapy in taxane-treated metastatic breast cancer: an open-label, multi-center, non-comparative phase II study

• Open Access
• Research article

Kun-Ming Rau, Yung-Chang Lin, Yen-Yang Chen, Jen-Shi Chen, Kuan-Der Lee, Cheng-Hsu Wang, Hsien-Kun Chang

How do we estimate survival? External validation of a tool for survival estimation in patients with metastatic bone disease—decision analysis and comparison of three international patient populations

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Andrea Piccioli, M. Silvia Spinelli, Jonathan A. Forsberg, Rikard Wedin, John H. Healey, Vincenzo Ippolito, Primo Andrea Daolio, Pietro Ruggieri, Giulio Maccauro, Alessandro Gasbarrini, Roberto Biagini, Raimondo Piana, Flavio Fazioli, Alessandro Luzzati, Alberto Di Martino, Francesco Nicolosi, Francesco Camnasio, Michele Attilio Rosa, Domenico Andrea Campanacci, Vincenzo Denaro, Rodolfo Capanna

Iron-free and iron-saturated bovine lactoferrin inhibit survivin expression and differentially modulate apoptosis in breast cancer

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Jessica A. Gibbons, Jagat R. Kanwar, Rupinder K. Kanwar

A case of metastatic renal cell carcinoma and bile duct carcinoma treated with a combination of sunitinib and gemcitabine

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• Case report

Kotoe Takayoshi, Kosuke Sagara, Keita Uchino, Hitoshi Kusaba, Naotaka Sakamoto, Atsushi Iguchi, Eishi Baba

Tumor-induced loss of mural Connexin 43 gap junction activity promotes endothelial proliferation

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Mayur Choudhary, Christine Naczki, Wenhong Chen, Keith D. Barlow, L. Douglas Case, Linda J. Metheny-Barlow

Adjuvant hyperthermic intraperitoneal chemotherapy (HIPEC) in patients with colon cancer at high risk of peritoneal carcinomatosis; the COLOPEC randomized multicentre trial

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• Study protocol

Charlotte E L Klaver, Gijsbert D Musters, Willem A Bemelman, Cornelis J A Punt, Victor J Verwaal, Marcel GW Dijkgraaf, Arend GJ Aalbers, Jarmila DW van der Bilt, Djamila Boerma, Andre JA Bremers, Jacobus WA Burger, Christianne J Buskens, Pauline Evers, Robert J van Ginkel, Wilhelmina MU van Grevenstein, Patrick HJ Hemmer, Ignace HJT de Hingh, Laureen A Lammers, Barbara L van Leeuwen, Wilhelmus JHJ Meijerink, Simon W Nienhuijs, Jolien Pon, Sandra A Radema, Bert van Ramshorst, Petur Snaebjornsson, Jurriaan B Tuynman, Elisabeth A te Velde, Marinus J Wiezer, Johannes HW de Wilt, Pieter J Tanis

Leucopenia and treatment efficacy in advanced nasopharyngeal carcinoma

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Zhen Su, Yan-Ping Mao, Pu-Yun OuYang, Jie Tang, Xiao-Wen Lan, Fang-Yun Xie

DECIDER: prospective randomized multicenter phase II trial of low-dose decitabine (DAC) administered alone or in combination with the histone deacetylase inhibitor valproic acid (VPA) and all-trans retinoic acid (ATRA) in patients >60 years with acute myeloid leukemia who are ineligible for induction chemotherapy

• Open Access
• Study protocol

Olga Grishina, Claudia Schmoor, Konstanze Döhner, Björn Hackanson, Beate Lubrich, Annette M. May, Caroline Cieslik, Michael J. Müller, Michael Lübbert

Low expression levels of hepsin and TMPRSS3 are associated with poor breast cancer survival

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Mikko Pelkonen, Kaisa Luostari, Maria Tengström, Hermanni Ahonen, Bozena Berdel, Vesa Kataja, Ylermi Soini, Veli-Matti Kosma, Arto Mannermaa

BCG+MMC trial: adding mitomycin C to BCG as adjuvant intravesical therapy for high-risk, non-muscle-invasive bladder cancer: a randomised phase III trial (ANZUP 1301)

• Open Access
• Study protocol

Dickon Hayne, Martin Stockler, Steve P. McCombie, Venu Chalasani, Anne Long, Andrew Martin, Shomik Sengupta, Ian D. Davis

Polymorphisms and plasma levels of IL-27: impact on genetic susceptibility and clinical outcome of bladder cancer

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Bin Zhou, Peng Zhang, Tielong Tang, Hong Liao, Kui Zhang, Yan Pu, Peng Chen, Yaping Song, Lin Zhang

Effect of genetic ancestry on leukocyte global DNA methylation in cancer patients

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Mónica Cappetta, María Berdasco, Jimena Hochmann, Carolina Bonilla, Mónica Sans, Pedro C Hidalgo, Nora Artagaveytia, Rick Kittles, Miguel Martínez, Manel Esteller, Bernardo Bertoni

Effects of statin use on volumetric mammographic density: results from the KARMA study

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Ida Skarping, Judith S. Brand, Per Hall, Signe Borgquist

Compounds identified by virtual docking to a tetrameric EGFR extracellular domain can modulate Grb2 internalization

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Ursula D. Ramirez, Anna S. Nikonova, Hanqing Liu, Anna Pecherskaya, Sarah H. Lawrence, Ilya G. Serebriiskii, Yan Zhou, Matthew K. Robinson, Margret B. Einarson, Erica A. Golemis, Eileen K. Jaffe

MicroRNA-217 functions as a prognosis predictor and inhibits colorectal cancer cell proliferation and invasion via an AEG-1 dependent mechanism

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Bo Wang, Zhan-long Shen, Ke-wei Jiang, Gang Zhao, Chun-you Wang, Yi-chao Yan, Yang Yang, Ji-zhun Zhang, Chao Shen, Zhi-dong Gao, Ying-jiang Ye, Shan Wang

Micro actions in colorectal cancer screening participation: a population-based survey study

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Siu Hing Lo, Jo Waller, Charlotte Vrinten, Christian von Wagner

A GSDMB enhancer-driven HSV thymidine kinase-expressing vector for controlling occult peritoneal dissemination of gastric cancer cells

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Norihisa Saeki, Rie Komatsuzaki, Fumiko Chiwaki, Kazuyoshi Yanagihara, Hiroki Sasaki

17β-estradiol induces stearoyl-CoA desaturase-1 expression in estrogen receptor-positive breast cancer cells

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Anissa Belkaid, Sabrina R. Duguay, Rodney J. Ouellette, Marc E. Surette

Prognostic impact of CXCL16 and CXCR6 in non-small cell lung cancer: combined high CXCL16 expression in tumor stroma and cancer cells yields improved survival

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Sigurd M. Hald, Yury Kiselev, Samer Al-Saad, Elin Richardsen, Charles Johannessen, Marte Eilertsen, Thomas K. Kilvaer, Khalid Al-Shibli, Sigve Andersen, Lill-Tove Busund, Roy M. Bremnes, Tom Donnem

Multiple gene aberrations and breast cancer: lessons from super-responders

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• Case report

Jennifer J. Wheler, Johnique T. Atkins, Filip Janku, Stacy L. Moulder, Roman Yelensky, Philip J. Stephens, Razelle Kurzrock

Early Palliative Care—Health services research and implementation of sustainable changes: the study protocol of the EVI project

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• Study protocol

Cornelia Meffert, Jan Gaertner, Katharina Seibel, Karin Jors, Hubert Bardenheuer, Dieter Buchheidt, Regine Mayer-Steinacker, Marén Viehrig, Christina Paul, Stephanie Stock, Carola Xander, Gerhild Becker

Identification of markers that functionally define a quiescent multiple myeloma cell sub-population surviving bortezomib treatment

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Alfred Adomako, Veronica Calvo, Noa Biran, Keren Osman, Ajai Chari, James C Paton, Adrienne W Paton, Kateri Moore, Denis M Schewe, Julio A Aguirre-Ghiso

Psychogenic fever in a patient with small cell lung cancer: a case report

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• Case report

Mengdan Xu, Xiaoye Zhang, Zhaoguo Xu, Guoyuan Cui, Li Yu, Xiaoying Qi, Jia Lin, Yan Liu

Childhood cancer mortality in Japan, 1980–2013

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Limin Yang, Junichiro Fujimoto

Lymph node density as a prognostic variable in node-positive bladder cancer: a meta-analysis

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Ja Hyeon Ku, Minyong Kang, Hyung Suk Kim, Chang Wook Jeong, Cheol Kwak, Hyeon Hoe Kim

miR-16 promotes the apoptosis of human cancer cells by targeting FEAT

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Hongwei Liang, Zheng Fu, Xueyuan Jiang, Nan Wang, Feng Wang, Xueliang Wang, Suyang Zhang, Yanbo Wang, Xin Yan, Wen-xian Guan, Chen-Yu Zhang, Ke Zen, Yujing Zhang, Xi Chen, Guangxin Zhou

Consumption of hot beverages and foods and the risk of esophageal cancer: a meta-analysis of observational studies

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Yawen Chen, Yeqing Tong, Chen Yang, Yong Gan, Huilian Sun, Huashan Bi, Shiyi Cao, Xiaoxv Yin, Zuxun Lu

The diagnostic challenge of pulmonary tumour thrombotic microangiopathy as a presentation for metastatic gastric cancer: a case report and review of the literature

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• Case report

Andrew LK. Ho, Patryk Szulakowsi, Waria HS. Mohamid

c-Met in esophageal squamous cell carcinoma: an independent prognostic factor and potential therapeutic target

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Yohei Ozawa, Yasuhiro Nakamura, Fumiyoshi Fujishima, Saulo JA Felizola, Kenichiro Takeda, Hiroshi Okamoto, Ken Ito, Hirotaka Ishida, Takuro Konno, Takashi Kamei, Go Miyata, Noriaki Ohuchi, Hironobu Sasano

Randomized phase II study of S-1 dosing schedule for resected colorectal cancer

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• Study protocol

Chu Matsuda, Mamoru Uemura, Ken Nakata, Tatsushi Shingai, Junichi Nishimura, Taishi Hata, Masakazu Ikenaga, Ichiro Takemasa, Tsunekazu Mizushima, Takeshi Kato, Masataka Ikeda, Masayuki Ohue, Kohei Murata, Junichi Hasegawa, Taroh Satoh, Hirofumi Yamamoto, Mitsugu Sekimoto, Riichiro Nezu, Yuichiro Doki, Masaki Mori

TIF1γ interferes with TGFβ1/SMAD4 signaling to promote poor outcome in operable breast cancer patients

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Loay Kassem, Mathieu Deygas, Laurent Fattet, Jonathan Lopez, Thibaut Goulvent, Emilie Lavergne, Sylvie Chabaud, Nicolas Carrabin, Nicolas Chopin, Thomas Bachelot, Germain Gillet, Isabelle Treilleux, Ruth Rimokh

Identification and validation of dysregulated MAPK7 (ERK5) as a novel oncogenic target in squamous cell lung and esophageal carcinoma

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Paul R. Gavine, Mei Wang, Dehua Yu, Eva Hu, Chunlei Huang, Jenny Xia, Xinying Su, Joan Fan, Tianwei Zhang, Qingqing Ye, Li Zheng, Guanshan Zhu, Ziliang Qian, Qingquan Luo, Ying Yong Hou, Qunsheng Ji

Vinflunine in routine clinical practice for the treatment of advanced or metastatic urothelial cell carcinoma - data from a prospective, multicenter experience

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Margitta Retz, Patrick de Geeter, Peter J. Goebell, Ullrich Matz, Wito de Schultz, Axel Hegele

Matrix metalloproteases as maestros for the dual role of LPS- and IL-10-stimulated macrophages in cancer cell behaviour

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Ana P. Cardoso, Marta L. Pinto, Ana T. Pinto, Marta T. Pinto, Cátia Monteiro, Marta I. Oliveira, Susana G. Santos, João B. Relvas, Raquel Seruca, Alberto Mantovani, Marc Mareel, Mário A. Barbosa, Maria J. Oliveira

APC selectively mediates response to chemotherapeutic agents in breast cancer

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Monica K. VanKlompenberg, Claire O. Bedalov, Katia Fernandez Soto, Jenifer R. Prosperi

Categorical versus continuous circulating tumor cell enumeration as early surrogate marker for therapy response and prognosis during docetaxel therapy in metastatic prostate cancer patients

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Mark Thalgott, Brigitte Rack, Matthias Eiber, Michael Souvatzoglou, Matthias M. Heck, Caroline Kronester, Ulrich Andergassen, Victoria Kehl, Bernd J. Krause, Jurgen E. Gschwend, Margitta Retz, Roman Nawroth

Cohort profile: cholangiocarcinoma screening and care program (CASCAP)

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• Study protocol

Narong Khuntikeo, Nittaya Chamadol, Puangrat Yongvanit, Watcharin Loilome, Nisana Namwat, Paiboon Sithithaworn, Ross H. Andrews, Trevor N. Petney, Supannee Promthet, Kavin Thinkhamrop, Chaiwat Tawarungruang, Bandit Thinkhamrop

Intratumor cholesteryl ester accumulation is associated with human breast cancer proliferation and aggressive potential: a molecular and clinicopathological study

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David de Gonzalo-Calvo, Laura López-Vilaró, Laura Nasarre, Maitane Perez-Olabarria, Tania Vázquez, Daniel Escuin, Lina Badimon, Agusti Barnadas, Enrique Lerma, Vicenta Llorente-Cortés

MiR-223 targeting MAFB suppresses proliferation and migration of nasopharyngeal carcinoma cells

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Wanyong Yang, Xi Lan, Dongmin Li, Tao Li, Shemin Lu

Combined inhibition of the cell cycle related proteins Wee1 and Chk1/2 induces synergistic anti-cancer effect in melanoma

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Gry Irene Magnussen, Elisabeth Emilsen, Karianne Giller Fleten, Birgit Engesæter, Viola Nähse-Kumpf, Roar Fjær, Ana Slipicevic, Vivi Ann Flørenes

Enhanced caveolin-1 expression increases migration, anchorage-independent growth and invasion of endometrial adenocarcinoma cells

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Natalia Diaz-Valdivia, Denisse Bravo, Hernán Huerta, Soledad Henriquez, Fernando Gabler, Margarita Vega, Carmen Romero, Claudia Calderon, Gareth I. Owen, Lisette Leyton, Andrew F. G. Quest

Cytotoxic effects of replication-competent adenoviruses on human esophageal carcinoma are enhanced by forced p53 expression

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Shan Yang, Kiyoko Kawamura, Shinya Okamoto, Suguru Yamauchi, Masato Shingyoji, Ikuo Sekine, Hiroshi Kobayashi, Yuji Tada, Koichiro Tatsumi, Kenzo Hiroshima, Hideaki Shimada, Masatoshi Tagawa

Conventional transarterial chemoembolization versus drug-eluting bead transarterial chemoembolization for the treatment of hepatocellular carcinoma

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Roman Kloeckner, Arndt Weinmann, Friederike Prinz, Daniel Pinto dos Santos, Christian Ruckes, Christoph Dueber, Michael Bernhard Pitton

A 3D-microtissue-based phenotypic screening of radiation resistant tumor cells with synchronized chemotherapeutic treatment

• Open Access
• Technical advance

Nataša Anastasov, Ines Höfig, Vanja Radulović, Simon Ströbel, Michael Salomon, Jan Lichtenberg, Ina Rothenaigner, Kamyar Hadian, Jens M. Kelm, Christian Thirion, Michael J. Atkinson

Study design and rationale for a randomised, placebo-controlled, double-blind study to assess the efficacy of selumetinib (AZD6244; ARRY-142886) in combination with dacarbazine in patients with metastatic uveal melanoma (SUMIT)

• Open Access
• Study protocol

Richard D. Carvajal, Gary K. Schwartz, Helen Mann, Ian Smith, Paul D. Nathan

The prognostic role of HER2 expression in ductal breast carcinoma in situ (DCIS); a population-based cohort study

• Open Access
• Research article

Signe Borgquist, Wenjing Zhou, Karin Jirström, Rose-Marie Amini, Thomas Sollie, Therese Sørlie, Carl Blomqvist, Salma Butt, Fredrik Wärnberg

microRNA-34a inhibits epithelial mesenchymal transition in human cholangiocarcinoma by targeting Smad4 through transforming growth factor-beta/Smad pathway

• Open Access
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Pengfei Qiao, Guodong Li, Wen Bi, Lianmeng Yang, Lei Yao, Dequan Wu

TRIM8 downregulation in glioma affects cell proliferation and it is associated with patients survival

• Open Access
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Lucia Micale, Carmela Fusco, Andrea Fontana, Raffaela Barbano, Bartolomeo Augello, Pasquelena De Nittis, Massimiliano Copetti, Maria Teresa Pellico, Barbara Mandriani, Dario Cocciadiferro, Paola Parrella, Vito Michele Fazio, Lucia Maria Cecilia Dimitri, Vincenzo D’Angelo, Chiara Novielli, Lidia Larizza, Antonio Daga, Giuseppe Merla

The role of the REG4 gene and its encoding product in ovarian epithelial carcinoma

• Open Access
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Shuo Chen, Wen-Feng Gou, Shuang Zhao, Zhe-Feng Niu, Yang Zhao, Yasuo Takano, Hua-Chuan Zheng

A microRNA molecular modeling extension for prediction of colorectal cancer treatment

• Open Access
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Jian Li, Ulrich R. Mansmann

Gene expression profiling leads to discovery of correlation of matrix metalloproteinase 11 and heparanase 2 in breast cancer progression

• Open Access
• Research article

Junjie Fu, Ravil Khaybullin, Yanping Zhang, Amy Xia, Xin Qi

The combination of methylsulfonylmethane and tamoxifen inhibits the Jak2/STAT5b pathway and synergistically inhibits tumor growth and metastasis in ER-positive breast cancer xenografts

• Open Access
• Research article

Nipin SP, Pramod Darvin, Young Beom Yoo, Youn Hee Joung, Dong Young Kang, Don Nam Kim, Tae Sook Hwang, Sang Yoon Kim, Wan Seop Kim, Hak Kyo Lee, Byung Wook Cho, Heui Soo Kim, Kyung Do Park, Jong Hwan Park, Soung Hoon Chang, Young Mok Yang

Concept and design of a nationwide prospective feasibility/efficacy/safety study of weekly paclitaxel for patients with pathologically confirmed anaplastic thyroid cancer (ATCCJ-PTX-P2)

• Open Access
• Study protocol

Naoyoshi Onoda, Iwao Sugitani, Takuya Higashiyama, Hisato Hara, Ken-ichi Ito, Makoto Kammori, Kiminori Sugino, Shinichi Suzuki, Kazuhisa Toda, Akira Yoshida, Akira Miyauchi

Constitutive expression of Bcl-2 induces epithelial-Mesenchymal transition in mammary epithelial cells

• Open Access
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Juan An, Jin Lv, Aimin Li, Junxiao Qiao, Liang Fang, Zhihua Li, Bo Li, Wei Zhao, Huoming Chen, Liying Wang

Effect of sulfasalazine on human neuroblastoma: analysis of sepiapterin reductase (SPR) as a new therapeutic target

• Open Access
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Lisette P. Yco, Dirk Geerts, Gabor Mocz, Jan Koster, André S. Bachmann

A cross-sectional study of high-risk human papillomavirus clustering and cervical outcomes in HIV-infected women in Rio de Janeiro, Brazil

• Open Access
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Jessica L. Castilho, José Eduardo Levi, Paula M. Luz, Mary Catherine Cambou, Tazio Vanni, Angela de Andrade, Mônica Derrico, Valdiléa G. Veloso, Beatriz Grinsztejn, Ruth K. Friedman

Pharmacological targeting of valosin containing protein (VCP) induces DNA damage and selectively kills canine lymphoma cells

• Open Access
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Marie-Ève Nadeau, Charlène Rico, Mayra Tsoi, Mélanie Vivancos, Sabin Filimon, Marilène Paquet, Derek Boerboom

LTA + 252A > G polymorphism is associated with risk of nasal NK/T-cell lymphoma in a Chinese population: a case-control study

• Open Access
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Sensen Cheng, Jianzhong Li, Wenjian Liu, Chengxiang Liu, Lei Su, Xiuchun Liu, Liangjun Guo, Yuan Ma, Bao Song, Jie Liu

Quantitative proteomic analysis shows differentially expressed HSPB1 in glioblastoma as a discriminating short from long survival factor and NOVA1 as a differentiation factor between low-grade astrocytoma and oligodendroglioma

• Open Access
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Marcela Gimenez, Suely Kazue Nagahashi Marie, Sueli Oba-Shinjo, Miyuki Uno, Clarice Izumi, João Bosco Oliveira, Jose Cesar Rosa

Investigating the performance and cost-effectiveness of the simple ultrasound-based rules compared to the risk of malignancy index in the diagnosis of ovarian cancer (SUBSONiC-study): protocol of a prospective multicenter cohort study in the Netherlands

• Open Access
• Study protocol

Evelyne MJ Meys, Iris JG Rutten, Roy FPM Kruitwagen, Brigitte F Slangen, Martin GM Bergmans, Helen JMM Mertens, Ernst Nolting, Dieuwke Boskamp, Regina GH Beets-Tan, Toon van Gorp

Menacalc, a quantitative method of metastasis assessment, as a prognostic marker for axillary node-negative breast cancer

• Open Access
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Catherine L. Forse, Seema Agarwal, Dushanthi Pinnaduwage, Frank Gertler, John S. Condeelis, Juan Lin, Xiaonan Xue, Kimberly Johung, Anna Marie Mulligan, Thomas E. Rohan, Shelley B. Bull, Irene L. Andrulis

The prognostic impact of mutations in spliceosomal genes for myelodysplastic syndrome patients without ring sideroblasts

• Open Access
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Min-Gu Kang, Hye-Ran Kim, Bo-Young Seo, Jun Hyung Lee, Seok-Yong Choi, Soo-Hyun Kim, Jong-Hee Shin, Soon-Pal Suh, Jae-Sook Ahn, Myung-Geun Shin

Distribution of cervical intraepithelial neoplasia on the cervix in Chinese women: pooled analysis of 19 population based screening studies

• Open Access
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Yu-qian Zhao, Irene J. Chang, Fang-hui Zhao, Shang-ying Hu, Jennifer S. Smith, Xun Zhang, Shu-min Li, Ping Bai, Wen-hua Zhang, You-lin Qiao

Multimodality therapy approaches, local and systemic treatment, compared with chemotherapy alone in recurrent glioblastoma

• Open Access
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Marta Scorsetti, Pierina Navarria, Federico Pessina, Anna Maria Ascolese, Giuseppe D’Agostino, Stefano Tomatis, Fiorenza De Rose, Elisa Villa, Giulia Maggi, Matteo Simonelli, Elena Clerici, Riccardo Soffietti, Armando Santoro, Luca Cozzi, Lorenzo Bello

PIpelle Prospective ENDOmetrial carcinoma (PIPENDO) study, pre-operative recognition of high risk endometrial carcinoma: a multicentre prospective cohort study

• Open Access
• Study protocol

Nicole C. M. Visser, Johan Bulten, Anneke A. M. van der Wurff, Erik A. Boss, Carolien M. Bronkhorst, Harrie W. H. Feijen, Joke E. Haartsen, Hilde A. D. M. van Herk, Ineke M. de Kievit, Paul J. J. M. Klinkhamer, Brenda M. Pijlman, Marc P. M. L. Snijders, Ingrid Vandenput, M. Caroline Vos, Peter E. J. de Wit, Lonneke V. van de Poll-Franse, Leon F.A.G. Massuger, Johanna M. A. Pijnenborg

The truncated splice variant of peroxisome proliferator-activated receptor alpha, PPARα-tr, autonomously regulates proliferative and pro-inflammatory genes

• Open Access
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Maria Thomas, Christine Bayha, Kathrin Klein, Simon Müller, Thomas S. Weiss, Matthias Schwab, Ulrich M. Zanger

Anticancer drug sensitivity prediction in cell lines from baseline gene expression through recursive feature selection

• Open Access
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Zuoli Dong, Naiqian Zhang, Chun Li, Haiyun Wang, Yun Fang, Jun Wang, Xiaoqi Zheng

Helping cancer patients quit smoking by increasing their risk perception: a study protocol of a cluster randomized controlled trial

• Open Access
• Study protocol

William H.C. Li, Sophia S.C. Chan, Kelvin M. P. Wang, T.H. Lam

Estrogen receptor α enhances the transcriptional activity of ETS-1 and promotes the proliferation, migration and invasion of neuroblastoma cell in a ligand dependent manner

• Open Access
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Peng Cao, Fan Feng, Guofu Dong, Chunyong Yu, Sizhe Feng, Erlin Song, Guobing Shi, Yong Liang, Guobiao Liang

Inflammation-regulating factors in ascites as predictive biomarkers of drug resistance and progression-free survival in serous epithelial ovarian cancers

• Open Access
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Denis Lane, Isabelle Matte, Perrine Garde-Granger, Claude Laplante, Alex Carignan, Claudine Rancourt, Alain Piché

Preoperative serum 8-hydroxydeoxyguanosine is associated with chemoresistance and is a powerful prognostic factor in endometrioid-type epithelial ovarian cancer

• Open Access
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Marjo Pylväs-Eerola, Peeter Karihtala, Ulla Puistola

TRAIL-receptor preferences in pancreatic cancer cells revisited: Both TRAIL-R1 and TRAIL-R2 have a licence to kill

• Open Access
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Andrea Mohr, Rui Yu, Ralf M. Zwacka

Evaluation of the efficacy and safety of lanreotide in combination with targeted therapies in patients with neuroendocrine tumours in clinical practice: a retrospective cross-sectional analysis

• Open Access
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Jaume Capdevila, Isabel Sevilla, Vicente Alonso, Luís Antón Aparicio, Paula Jiménez Fonseca, Enrique Grande, Juan José Reina, José Luís Manzano, Juan Domingo Alonso Lájara, Jorge Barriuso, Daniel Castellano, Javier Medina, Carlos López, Ángel Segura, Sergio Carrera, Guillermo Crespo, José Fuster, Javier Munarriz, Pilar García Alfonso

STRATEGIC-1: A multiple-lines, randomized, open-label GERCOR phase III study in patients with unresectable wild-type RAS metastatic colorectal cancer

• Open Access
• Study protocol

Benoist Chibaudel, Franck Bonnetain, Christophe Tournigand, Marine Hug de Larauze, Armand de Gramont, Pierre Laurent-Puig, Jérôme Paget, Alexandra Hadengue, Dominique Notelet, Magdalena Benetkiewicz, Thierry André, Aimery de Gramont

Variations of BRAF mutant allele percentage in melanomas

• Open Access
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Zofia Hélias-Rodzewicz, Elisa Funck-Brentano, Laure Baudoux, Chan Kwon Jung, Ute Zimmermann, Cristi Marin, Thierry Clerici, Catherine Le Gall, Frédérique Peschaud, Valérie Taly, Philippe Saiag, Jean-François Emile

The different role of intratumoral and peritumoral lymphangiogenesis in gastric cancer progression and prognosis

• Open Access
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Kyung Ho Pak, Ara Jo, Hye Ji Choi, Younghee Choi, Hyunki Kim, Jae-Ho Cheong

MiR-190b, the highest up-regulated miRNA in ERα-positive compared to ERα-negative breast tumors, a new biomarker in breast cancers?

• Open Access
• Research article

Geraldine Cizeron-Clairac, François Lallemand, Sophie Vacher, Rosette Lidereau, Ivan Bieche, Celine Callens

Primary care characteristics and stage of cancer at diagnosis using data from the national cancer registration service, quality outcomes framework and general practice information

• Open Access
• Research article

Rebecca Maclean, Mona Jeffreys, Alex Ives, Tim Jones, Julia Verne, Yoav Ben-Shlomo

The Functionality Assessment Flowchart (FAF): a new simple and reliable method to measure performance status with a high percentage of agreement between observers

• Open Access
• Research article

Carlos Eduardo Paiva, Felipe Augusto Ferreira Siquelli, Henrique Amorim Santos, Marina Moreira Costa, Daniella Ramone Massaro, Domício Carvalho Lacerda, João Soares Nunes, Cristiano de Pádua Souza, Bianca Sakamoto Ribeiro Paiva

The expression of aldehyde dehydrogenase 1 (ALDH1) in ovarian carcinomas and its clinicopathological associations: a retrospective study

• Open Access
• Research article

Ruixia Huang, Xiaoran Li, Ruth Holm, Claes G. Trope, Jahn M. Nesland, Zhenhe Suo

ComOn Coaching: Study protocol of a randomized controlled trial to assess the effect of a varied number of coaching sessions on transfer into clinical practice following communication skills training

• Open Access
• Study protocol

Marcelo Niglio de Figueiredo, Bärbel Rodolph, Carma L Bylund, Tanja Goelz, Pia Heußner, Heribert Sattel, Kurt Fritzsche, Alexander Wuensch

Enhanced efficacy of photodynamic therapy by inhibiting ABCG2 in colon cancers

• Open Access
• Research article

Ju Hee Kim, Jae Myung Park, Yoon Jin Roh, In-Wook Kim, Tayyaba Hasan, Myung-Gyu Choi

Enhancing adherence in trials promoting change in diet and physical activity in individuals with a diagnosis of colorectal adenoma; a systematic review of behavioural intervention approaches

• Open Access
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Deborah McCahon, Amanda J. Daley, Janet Jones, Richard Haslop, Arjun Shajpal, Aliki Taylor, Sue Wilson, George Dowswell

Comparative microRNA profiling of sporadic and BRCA1 associated basal-like breast cancers

• Open Access
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Max Yan, Kristy Shield-Artin, David Byrne, Siddhartha Deb, Nic Waddell, Izhak Haviv, Stephen B Fox

Acrokeratosis paraneoplastica in serous ovarian carcinoma: case report

• Open Access
• Case report

Aline Hempen, Eleftherios P Samartzis, Jivko Kamarachev, Daniel Fink, Konstantin J Dedes

Polish experience of lenalidomide in the treatment of lower risk myelodysplastic syndrome with isolated del(5q)

• Open Access
• Research article

Aleksandra Butrym, Ewa Lech-Maranda, Elżbieta Patkowska, Beata Kumiega, Maria Bieniaszewska, Andrzej Mital, Krzysztof Madry, Tigran Torosian, Ryszard Wichary, Justyna Rybka, Krzysztof Warzocha, Grzegorz Mazur

Methylation-associated Has-miR-9 deregulation in paclitaxel- resistant epithelial ovarian carcinoma

• Open Access
• Research article

Xiao Li, Qianqian Pan, Xiaoyun Wan, Yuyan Mao, Weiguo Lu, Xing Xie, Xiaodong Cheng

The effectiveness and safety of platinum-based pemetrexed and platinum-based gemcitabine treatment in patients with malignant pleural mesothelioma

• Open Access
• Research article

Guntulu Ak, Selma Metintas, Muhittin Akarsu, Muzaffer Metintas

Neoadjuvant FOLFOX 4 versus FOLFOX 4 with Cetuximab versus immediate surgery for high-risk stage II and III colon cancers: a multicentre randomised controlled phase II trial – the PRODIGE 22 - ECKINOXE trial

• Open Access
• Study protocol

Mehdi Karoui, Anne Rullier, Alain Luciani, Franck Bonnetain, Marie-Luce Auriault, Antony Sarran, Geneviève Monges, Hervé Trillaud, Karine Le Malicot, Karen Leroy, Iradj Sobhani, Armelle Bardier, Marie Moreau, Isabelle Brindel, Jean François Seitz, Julien Taieb

The Breast Cancer to Bone (B2B) Metastases Research Program: a multi-disciplinary investigation of bone metastases from breast cancer

• Open Access
• Study protocol

Nigel T. Brockton, Stephanie J. Gill, Stephanie L. Laborge, Alexander H. G. Paterson, Linda S. Cook, Hans J. Vogel, Carrie S. Shemanko, David A. Hanley, Anthony M. Magliocco, Christine M. Friedenreich

The combination of intravenous Reolysin and gemcitabine induces reovirus replication and endoplasmic reticular stress in a patient with KRAS-activated pancreatic cancer

• Open Access
• Case report

Devalingam Mahalingam, Sukeshi Patel, Gerard Nuovo, George Gill, Giovanni Selvaggi, Matt Coffey, Steffan T. Nawrocki

Acquired genetic alterations in tumor cells dictate the development of high-risk neuroblastoma and clinical outcomes

• Open Access
• Research article

Faizan H. Khan, Vijayabaskar Pandian, Satishkumar Ramraj, Mohan Natarajan, Sheeja Aravindan, Terence S. Herman, Natarajan Aravindan

Noncompliance to guidelines in head and neck cancer treatment; associated factors for both patient and physician

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Emilie A. C. Dronkers, Steven W. Mes, Marjan H. Wieringa, Marc P. van der Schroeff, Robert J. Baatenburg de Jong

Pan-cancer analysis of TCGA data reveals notable signaling pathways

• Open Access
• Research article

Richard Neapolitan, Curt M. Horvath, Xia Jiang

Locally ablative treatment of breast cancer liver metastases: identification of factors influencing survival (the Mammary Cancer Microtherapy and Interventional Approaches (MAMMA MIA) study)

• Open Access
• Research article

Max Seidensticker, Benjamin Garlipp, Sophia Scholz, Konrad Mohnike, Felix Popp, Ingo Steffen, Ricarda Seidensticker, Patrick Stübs, Maciej Pech, Maciej PowerskI, Peter Hass, Serban-Dan Costa, Holger Amthauer, Christiane Bruns, Jens Ricke

Expression of pre-selected TMEMs with predicted ER localization as potential classifiers of ccRCC tumors

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Tomasz Wrzesiński, Malgorzata Szelag, Wojciech A. Cieślikowski, Agnieszka Ida, Rachel Giles, Elżbieta Zodro, Joanna Szumska, Joanna Poźniak, Zbigniew Kwias, Hans A.R. Bluyssen, Joanna Wesoly

Prospective cohort study using the breast cancer spheroid model as a predictor for response to neoadjuvant therapy – the SpheroNEO study

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Kathrin Halfter, Nina Ditsch, Hans-Christian Kolberg, Holger Fischer, Tanja Hauzenberger, Franz Edler von Koch, Ingo Bauerfeind, Gunter von Minckwitz, Ilona Funke, Alexander Crispin, Barbara Mayer

Ki-67 as a prognostic marker in early-stage non-small cell lung cancer in Asian patients: a meta-analysis of published studies involving 32 studies

• Open Access
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Song Wen, Wei Zhou, Chun-ming Li, Juan Hu, Xiao-ming Hu, Ping Chen, Guo-liang Shao, Wu-hua Guo

The prognostic significance of the postoperative prognostic nutritional index in patients with colorectal cancer

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Masatsune Shibutani, Kiyoshi Maeda, Hisashi Nagahara, Hiroshi Ohtani, Yasuhito Iseki, Tetsuro Ikeya, Kenji Sugano, Kosei Hirakawa

A new anti-glioma therapy, AG119: pre-clinical assessment in a mouse GL261 glioma model

• Open Access
• Research article

Rheal A. Towner, Michael Ihnat, Debra Saunders, Anja Bastian, Nataliya Smith, Roheeth Kumar Pavana, Aleem Gangjee

Spectrum and frequencies of BRCA1/2 mutations in Bulgarian high risk breast cancer patients

• Open Access
• Research article

Rumyana Ivanova Dodova, Atanaska Velichkova Mitkova, Daniela Rosenova Dacheva, Lina Basam Hadjo, Alexandrina Ivanova Vlahova, Margarita Stoyanova Taushanova - Hadjieva, Spartak Stoyanov Valev, Marija Mitko Caulevska, Stanislava Dimitrova Popova, Ivan Emilov Popov, Tihomir Iliichev Dikov, Theophil Angelov Sedloev, Atanas Stefanov Ionkov, Konstanta Velinova Timcheva, Svetlana Liubomirova Christova, Ivo Marinov Kremensky, Vanio Ivanov Mitev, Radka Petrova Kaneva

Expression of an estrogen-regulated variant transcript of the peroxisomal branched chain fatty acid oxidase ACOX2 in breast carcinomas

• Open Access
• Research article

Sunniva Stordal Bjørklund, Vessela N. Kristensen, Michael Seiler, Surendra Kumar, Grethe I. Grenaker Alnæs, Yao Ming, John Kerrigan, Bjørn Naume, Ravi Sachidanandam, Gyan Bhanot, Anne-Lise Børresen-Dale, Shridar Ganesan

A small molecular agent YL529 inhibits VEGF-D-induced lymphangiogenesis and metastasis in preclinical tumor models in addition to its known antitumor activities

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• Research article

Youzhi Xu, Wenjie Lu, Peng Yang, Wen Peng, Chunting Wang, Manli Li, Yan Li, Guobo Li, Nana Meng, Hongjun Lin, Lixin Kan, Siying Wang, Shengyong Yang, Luoting Yu, YingLan Zhao

Audiovisual biofeedback breathing guidance for lung cancer patients receiving radiotherapy: a multi-institutional phase II randomised clinical trial

• Open Access
• Study protocol

Sean Pollock, Ricky O’Brien, Kuldeep Makhija, Fiona Hegi-Johnson, Jane Ludbrook, Angela Rezo, Regina Tse, Thomas Eade, Roland Yeghiaian-Alvandi, Val Gebski, Paul J Keall

A potential small-molecule synthetic antilymphangiogenic agent norcantharidin inhibits tumor growth and lymphangiogenesis of human colonic adenocarcinomas through blocking VEGF-A,-C,-D/VEGFR-2,-3 “multi-points priming” mechanisms in vitro and in vivo

• Open Access
• Research article

Xin-Ping Li, Wei Jing, Jian-Jun Sun, Zhong-Yan Liu, Jing-Tao Zhang, Wei Sun, Wei Zhu, Yue-Zu Fan

STAT3 polymorphism and Helicobacter pylori CagA strains with higher number of EPIYA-C segments independently increase the risk of gastric cancer

• Open Access
• Research article

Gifone A Rocha, Andreia MC Rocha, Adriana D Gomes, César LL Faria Jr, Fabrício F Melo, Sérgio A Batista, Viviane C Fernandes, Nathálie BF Almeida, Kádima N Teixeira, Kátia S Brito, Dulciene Maria Magalhães Queiroz

Targeting mTOR/p70S6K/glycolysis signaling pathway restores glucocorticoid sensitivity to 4E-BP1 null Burkitt Lymphoma

• Open Access
• Research article

Ling Gu, Liping Xie, Chuan Zuo, Zhigui Ma, Yanle Zhang, Yiping Zhu, Ju Gao

Tumour shrinkage at 6 weeks predicts favorable clinical outcomes in a phase III study of gemcitabine and oxaliplatin with or without erlotinib for advanced biliary tract cancer

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• Research article

Seung Tae Kim, Kee-Taek Jang, Su Jin Lee, Hye-Lim Jang, Jeeyun Lee, Se Hoon Park, Young Suk Park, Ho Yeong Lim, Won Ki Kang, Joon Oh Park

Nrf2 is a potential prognostic marker and promotes proliferation and invasion in human hepatocellular carcinoma

• Open Access
• Research article

Mingxin Zhang, Chao Zhang, Lingmin Zhang, Qi Yang, Suna Zhou, Qinsheng Wen, Jingjie Wang

TOPGEAR: a randomised phase III trial of perioperative ECF chemotherapy versus preoperative chemoradiation plus perioperative ECF chemotherapy for resectable gastric cancer (an international, intergroup trial of the AGITG/TROG/EORTC/NCIC CTG)

• Open Access
• Study protocol

Trevor Leong, B Mark Smithers, Michael Michael, Val Gebski, Alex Boussioutas, Danielle Miller, John Simes, John Zalcberg, Karin Haustermans, Florian Lordick, Christoph Schuhmacher, Carol Swallow, Gail Darling, Rebecca Wong

Relationship between circulating tumor cells and epithelial to mesenchymal transition in early breast cancer

• Open Access
• Research article

M. Mego, Z. Cierna, P. Janega, M. Karaba, G. Minarik, J. Benca, T. Sedlácková, G. Sieberova, P. Gronesova, D. Manasova, D. Pindak, J. Sufliarsky, L. Danihel, JM Reuben, J. Mardiak

Monitoring therapeutic efficacy of sunitinib using [18F]FDG and [18F]FMISO PET in an immunocompetent model of luminal B (HER2-positive)-type mammary carcinoma

• Open Access
• Research article

Benoît Thézé, Nicholas Bernards, Audrey Beynel, Stephan Bouet, Bertrand Kuhnast, Irène Buvat, Bertrand Tavitian, Raphaël Boisgard

Collapsing focal segmental glomerulosclerosis following long-term treatment with oral ibandronate: case report and review of literature

• Open Access
• Case report

Ning Jia, Fionnuala C. Cormack, Bin Xie, Zita Shiue, Behzad Najafian, Julie R. Gralow

Overexpression of Class III β-tubulin, Sox2, and nuclear Survivin is predictive of taxane resistance in patients with stage III ovarian epithelial cancer

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Jintong Du, Bei Li, Yingli Fang, Yanguo Liu, Yang Wang, Jisheng Li, Wen Zhou, Xiuwen Wang

Linear accelerator-based stereotactic radiosurgery in 140 brain metastases from malignant melanoma

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• Research article

Henrik Hauswald, Alina Stenke, Jürgen Debus, Stephanie E. Combs

The prognostic value of SUMO1/Sentrin specific peptidase 1 (SENP1) in prostate cancer is limited to ERG-fusion positive tumors lacking PTEN deletion

• Open Access
• Research article

Christoph Burdelski, Devi Menan, Maria Christina Tsourlakis, Martina Kluth, Claudia Hube-Magg, Nathaniel Melling, Sarah Minner, Christina Koop, Markus Graefen, Hans Heinzer, Corinna Wittmer, Guido Sauter, Ronald Simon, Thorsten Schlomm, Stefan Steurer, Till Krech

Whole-exome sequencing of a rare case of familial childhood acute lymphoblastic leukemia reveals putative predisposing mutations in Fanconi anemia genes

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• Research article

Jean-François Spinella, Jasmine Healy, Virginie Saillour, Chantal Richer, Pauline Cassart, Manon Ouimet, Daniel Sinnett

Functional role of miR-10b in tamoxifen resistance of ER-positive breast cancer cells through down-regulation of HDAC4

• Open Access
• Research article

Aamir Ahmad, Kevin R. Ginnebaugh, Shuping Yin, Aliccia Bollig-Fischer, Kaladhar B. Reddy, Fazlul H. Sarkar

The burden of cervical pre-cancer and cancer in HIV positive women in Zambia: a modeling study

• Open Access
• Research article

Allen C. Bateman, Katundu Katundu, Mulindi H. Mwanahamuntu, Sharon Kapambwe, Vikrant V. Sahasrabuddhe, Michael L. Hicks, Benjamin H. Chi, Jeffrey S. A. Stringer, Groesbeck P. Parham, Carla J. Chibwesha

Functional microRNA high throughput screening reveals miR-9 as a central regulator of liver oncogenesis by affecting the PPARA-CDH1 pathway

• Open Access
• Research article

Alexandra Drakaki, Maria Hatziapostolou, Christos Polytarchou, Christina Vorvis, George A. Poultsides, John Souglakos, Vassilis Georgoulias, Dimitrios Iliopoulos

Early increase in circulating carbonic anhydrase IX during neoadjuvant treatment predicts favourable outcome in locally advanced rectal cancer

• Open Access
• Research article

Helga Helseth Hektoen, Kjersti Flatmark, Yvonne Andersson, Svein Dueland, Kathrine Røe Redalen, Anne Hansen Ree

Association of sarcopenia and observed physical performance with attainment of multidisciplinary team planned treatment in non-small cell lung cancer: an observational study protocol

• Open Access
• Study protocol

Jemima T. Collins, Simon Noble, John Chester, Helen E. Davies, William D. Evans, Jason Lester, Diane Parry, Rebecca J. Pettit, Anthony Byrne

High basal Wnt signaling is further induced by PI3K/mTor inhibition but sensitive to cSRC inhibition in mammary carcinoma cell lines with HER2/3 overexpression

• Open Access
• Research article

Elpetra P. M. Timmermans-Sprang, Ana Gracanin, Jan A. Mol

Digital imaging in the immunohistochemical evaluation of the proliferation markers Ki67, MCM2 and Geminin, in early breast cancer, and their putative prognostic value

• Open Access
• Research article

Shalaka Joshi, Johnathan Watkins, Patrycja Gazinska, John P. Brown, Cheryl E. Gillett, Anita Grigoriadis, Sarah E. Pinder

Identifying novel hypoxia-associated markers of chemoresistance in ovarian cancer

• Open Access
• Research article

Lynda M. McEvoy, Sharon A. O’Toole, Cathy D. Spillane, Cara M. Martin, Michael F. Gallagher, Britta Stordal, Gordon Blackshields, Orla Sheils, John J. O’Leary

Elevated C1orf63 expression is correlated with CDK10 and predicts better outcome for advanced breast cancers: a retrospective study

• Open Access
• Research article

Chao-Qun Hong, Fan Zhang, Yan-Jie You, Wei-Li Qiu, Armando E. Giuliano, Xiao-Jiang Cui, Guo-Jun Zhang, Yu-Kun Cui

CD147 expression predicts biochemical recurrence after prostatectomy independent of histologic and pathologic features

• Open Access
• Research article

Tyler M. Bauman, Jonathan A. Ewald, Wei Huang, William A. Ricke

GTSE1 expression represses apoptotic signaling and confers cisplatin resistance in gastric cancer cells

• Open Access
• Research article

Vinod Vijay Subhash, Shi Hui Tan, Woei Loon Tan, Mei Shi Yeo, Chen Xie, Foong Ying Wong, Zee Ying Kiat, Robert Lim, Wei Peng Yong

Lymphocyte-specific protein tyrosine kinase (Lck) interacts with CR6-interacting factor 1 (CRIF1) in mitochondria to repress oxidative phosphorylation

• Open Access
• Research article

Shahrooz Vahedi, Fu-Yu Chueh, Bala Chandran, Chao-Lan Yu

IL6 secreted by Ewing sarcoma tumor microenvironment confers anti-apoptotic and cell-disseminating paracrine responses in Ewing sarcoma cells

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• Research article

Andrej Lissat, Mandy Joerschke, Dheeraj A. Shinde, Till Braunschweig, Angelina Meier, Anna Makowska, Rachel Bortnick, Philipp Henneke, Georg Herget, Thomas A. Gorr, Udo Kontny

P-glycoprotein confers acquired resistance to 17-DMAG in lung cancers with an ALK rearrangement

• Open Access
• Research article

Hee Joung Kim, Kye Young Lee, Young Whan Kim, Yun Jung Choi, Jung-Eun Lee, Chang Min Choi, In-Jeoung Baek, Jin Kyung Rho, Jae Cheol Lee

Breast cancer survivors’ recollection of their illness and therapy seven years after enrolment into a randomised controlled clinical trial

• Open Access
• Research article

Patricia Lindberg, Michael Koller, Brunhilde Steinger, Wilfried Lorenz, Jeremy C. Wyatt, Elisabeth C. Inwald, Monika Klinkhammer-Schalke

Superior efficacy of rituximab-based chemoimmunotherapy as an initial therapy in newly diagnosed patients with B cell indolent lymphomas: long-term results from a single center in China

• Open Access
• Research article

Zengjun Li, Fei Li, Shuhua Yi, Zhimin Gu, Zhen Yu, Yan Xu, Xiaoyan Feng, Wei Liu, Dehui Zou, Junyuan Qi, Fenghuang Zhan, Lugui Qiu

Laparoscopic versus open gastrectomy for gastric cancer, a multicenter prospectively randomized controlled trial (LOGICA-trial)

• Open Access
• Study protocol

Leonie Haverkamp, Hylke JF Brenkman, Maarten FJ Seesing, Suzanne S Gisbertz, Mark I van Berge Henegouwen, Misha DP Luyer, Grard AP Nieuwenhuijzen, Bas PL Wijnhoven, Jan JB van Lanschot, Wobbe O de Steur, Henk H Hartgrink, Jan HMB Stoot, Karel WE Hulsewé, Ernst J Spillenaar Bilgen, Jeroen E Rütter, Ewout A Kouwenhoven, Marc J van Det, Donald L van der Peet, Freek Daams, Werner A Draaisma, Ivo AMJ Broeders, Henk F van Stel, Miangela M Lacle, Jelle P Ruurda, Richard van Hillegersberg

Population-based SEER trend analysis of overall and cancer-specific survival in 5138 patients with gastrointestinal stromal tumor

• Open Access
• Research article

Ulrich Güller, Ignazio Tarantino, Thomas Cerny, Bruno M. Schmied, Rene Warschkow

Impact of delays in initiating postoperative chemoradiation while determining the MGMT promoter-methylation statuses of patients with primary glioblastoma

• Open Access
• Research article

Sebastian Adeberg, Tilman Bostel, Semi Harrabi, Denise Bernhardt, Thomas Welzel, Wolfgang Wick, Juergen Debus, Stephanie E. Combs

A functional genetic variant in fragile-site gene FATS modulates the risk of breast cancer in triparous women

• Open Access
• Research article

Fangfang Song, Jun Zhang, Li Qiu, Yawen Zhao, Pan Xing, Jiachun Lu, Kexin Chen, Zheng Li

XAB2 tagSNPs contribute to non-small cell lung cancer susceptibility in Chinese population

• Open Access
• Research article

Na Pei, Lei Cao, Yingwen Liu, Jing Wu, Qinqin Song, Zhi Zhang, Juxiang Yuan, Xuemei Zhang

A novel cytosporone 3-Heptyl-4,6-dihydroxy-3H-isobenzofuran-1-one: synthesis; toxicological, apoptotic and immunomodulatory properties; and potentiation of mutagenic damage

• Open Access
• Research article

Rodrigo Juliano Oliveira, Stephanie Dynczuki Navarro, Dênis Pires de Lima, Alisson Meza, João Renato Pesarini, Roberto da Silva Gomes, Caroline Bilhar Karaziack, Mariana de Oliveira Mauro, Andréa Luiza Cunha-Laura, Antônio Carlos Duenhas Monreal, Wanderson Romão, Valdemar Lacerda Júnior, Adilson Beatriz

Neoplastic transformation of porcine mammary epithelial cells in vitro and tumor formation in vivo

• Open Access
• Research article

A. R. Rowson-Hodel, R. Manjarin, J. F. Trott, R. D. Cardiff, A. D. Borowsky, R. C. Hovey

Adenosine A2b receptor promotes progression of human oral cancer

• Open Access
• Research article

Hiroki Kasama, Yosuke Sakamoto, Atsushi Kasamatsu, Atsushi Okamoto, Tomoyoshi Koyama, Yasuyuki Minakawa, Katsunori Ogawara, Hidetaka Yokoe, Masashi Shiiba, Hideki Tanzawa, Katsuhiro Uzawa

Adjuvant chemotherapy with gemcitabine and cisplatin compared to observation after curative intent resection of cholangiocarcinoma and muscle invasive gallbladder carcinoma (ACTICCA-1 trial) - a randomized, multidisciplinary, multinational phase III trial

• Open Access
• Study protocol

Alexander Stein, Dirk Arnold, John Bridgewater, David Goldstein, Lars Henrik Jensen, Heinz-Josef Klümpen, Ansgar W. Lohse, Björn Nashan, John Primrose, Silke Schrum, Jenny Shannon, Eik Vettorazzi, Henning Wege

Prognostic significance of multiple kallikreins in high-grade astrocytoma

• Open Access
• Research article

Kristen L. Drucker, Caterina Gianinni, Paul A. Decker, Eleftherios P. Diamandis, Isobel A. Scarisbrick

A network meta-analysis of therapeutic outcomes after new image technology-assisted transurethral resection for non-muscle invasive bladder cancer: 5-aminolaevulinic acid fluorescence vs hexylaminolevulinate fluorescence vs narrow band imaging

• Open Access
• Research article

Joo Yong Lee, Kang Su Cho, Dong Hyuk Kang, Hae Do Jung, Jong Kyou Kwon, Cheol Kyu Oh, Won Sik Ham, Young Deuk Choi

Durable recurrence-free survival after pneumonectomy for late lung metastasis from rectal cancer: case report with genetic and epigenetic analyses

• Open Access
• Case report

Andrea Imperatori, Nicola Rotolo, Lorenzo Dominioni, Elisa Nardecchia, Maria Cattoni, Laura Cimetti, Cristina Riva, Fausto Sessa, Daniela Furlan

Obatoclax is a direct and potent antagonist of membrane-restricted Mcl-1 and is synthetic lethal with treatment that induces Bim

• Open Access
• Research article

Mai Nguyen, Regina Cencic, Franziska Ertel, Cynthia Bernier, Jerry Pelletier, Anne Roulston, John R. Silvius, Gordon C. Shore

Limited predictive value of achieving beneficial plasma (Z)-endoxifen threshold level by CYP2D6 genotyping in tamoxifen-treated Polish women with breast cancer

• Open Access
• Research article

Ewa E. Hennig, Magdalena Piatkowska, Jakub Karczmarski, Krzysztof Goryca, Elzbieta Brewczynska, Radoslaw Jazwiec, Anna Kluska, Robert Omiotek, Agnieszka Paziewska, Michal Dadlez, Jerzy Ostrowski

Extracellular vesicle-mediated phenotype switching in malignant and non-malignant colon cells

• Open Access
• Research article

Hillary E. Mulvey, Audrey Chang, Jason Adler, Michael Del Tatto, Kimberly Perez, Peter J. Quesenberry, Devasis Chatterjee

SDF-1alpha concentration dependent modulation of RhoA and Rac1 modifies breast cancer and stromal cells interaction

• Open Access
• Research article

Jennifer Pasquier, Nadine Abu-Kaoud, Houari Abdesselem, Aisha Madani, Jessica Hoarau-Véchot, Hamda Al. Thawadi, Fabien Vidal, Bettina Couderc, Gilles Favre, Arash Rafii

Satisfaction with fertility- and sexuality-related information in young women with breast cancer—ELIPPSE40 cohort

• Open Access
• Research article

Ali Ben Charif, Anne-Déborah Bouhnik, Dominique Rey, Magali Provansal, Blandine Courbiere, Bruno Spire, Julien Mancini

Tumor-associated macrophages in oral premalignant lesions coexpress CD163 and STAT1 in a Th1-dominated microenvironment

• Open Access
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Kazumasa Mori, Shigeki Haraguchi, Miki Hiori, Jun Shimada, Yoshihiro Ohmori

Texture analysis on MR images helps predicting non-response to NAC in breast cancer

• Open Access
• Research article

N. Michoux, S. Van den Broeck, L. Lacoste, L. Fellah, C. Galant, M. Berlière, I. Leconte

Expression and role of oncogenic miRNA-224 in esophageal squamous cell carcinoma

• Open Access
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Xiaoyan He, Zhimei Zhang, Ming Li, Shuo Li, Lihua Ren, Hong Zhu, Bin Xiao, Ruihua Shi

Magnolin inhibits cell migration and invasion by targeting the ERKs/RSK2 signaling pathway

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• Research article

Cheol-Jung Lee, Mee-Hyun Lee, Sun-Mi Yoo, Kyung-Il Choi, Ji-Hong Song, Jeong-Hoon Jang, Sei-Ryang Oh, Hyung-Won Ryu, Hye-Suk Lee, Young-Joon Surh, Yong-Yeon Cho

M1 and M2 macrophages derived from THP-1 cells differentially modulate the response of cancer cells to etoposide

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• Research article

Marie Genin, Francois Clement, Antoine Fattaccioli, Martine Raes, Carine Michiels

Variation in guideline adherence in non-Hodgkin’s lymphoma care: impact of patient and hospital characteristics

• Open Access
• Research article

Jozette J.C. Stienen, Rosella P.M.G. Hermens, Lianne Wennekes, Saskia A.M. van de Schans, Richard W.M. van der Maazen, Helena M. Dekker, Janine Liefers, Johan H.J.M. van Krieken, Nicole M.A. Blijlevens, Petronella B. Ottevanger

In vitro engineering of human 3D chondrosarcoma: a preclinical model relevant for investigations of radiation quality impact

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• Research article

Dounia Houria Hamdi, Sofia Barbieri, François Chevalier, Jean-Emmanuel Groetz, Florence Legendre, Magali Demoor, Philippe Galera, Jean-Louis Lefaix, Yannick Saintigny

The Kanker Nazorg Wijzer (Cancer Aftercare Guide) protocol: the systematic development of a web-based computer tailored intervention providing psychosocial and lifestyle support for cancer survivors

• Open Access
• Study protocol

Roy A Willems, Catherine AW Bolman, Ilse Mesters, Iris M Kanera, Audrey AJM Beaulen, Lilian Lechner

Moxifloxacin and ciprofloxacin induces S-phase arrest and augments apoptotic effects of cisplatin in human pancreatic cancer cells via ERK activation

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Vikas Yadav, Pallavi Varshney, Sarwat Sultana, Jyoti Yadav, Neeru Saini

LC3B globular structures correlate with survival in esophageal adenocarcinoma

• Open Access
• Research article

Shereen El-Mashed, Tracey R. O’Donovan, Elaine W. Kay, Ayat R. Abdallah, Mary-Clare Cathcart, Jacintha O’Sullivan, Anthony O’Grady, John Reynolds, Seamus O’Reilly, Gerald C. O’Sullivan, Sharon L. McKenna

Radical surgery versus standard surgery for primary cytoreduction of bulky stage IIIC and IV ovarian cancer: an observational study

• Open Access
• Research article

Yulan Ren, Rong Jiang, Sheng Yin, Chao You, Dongli Liu, Xi Cheng, Jie Tang, Rongyu Zang

Il-6 signaling between ductal carcinoma in situ cells and carcinoma-associated fibroblasts mediates tumor cell growth and migration

• Open Access
• Research article

Kingsley O. Osuala, Mansoureh Sameni, Seema Shah, Neha Aggarwal, Michelle L. Simonait, Omar E. Franco, Yan Hong, Simon W. Hayward, Fariba Behbod, Raymond R. Mattingly, Bonnie F. Sloane

Somatic drivers of B-ALL in a model of ETV6-RUNX1; Pax5 +/− leukemia

• Open Access
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Louise van der Weyden, George Giotopoulos, Kim Wong, Alistair G. Rust, Carla Daniela Robles-Espinoza, Hikari Osaki, Brian J. Huntly, David J. Adams

Bcl2 inhibition of mitochondrial DNA repair

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Maohua Xie, Paul W. Doetsch, Xingming Deng

Knowledge and attitudes regarding medical research studies among patients with breast cancer and gynecological diseases

• Open Access
• Research article

Michael P. Lux, Thomas Hildebrandt, Sandra-Maria Knetzger, Michael G. Schrauder, Sebastian M. Jud, Alexander Hein, Claudia Rauh, Peter A. Fasching, Matthias W. Beckmann, Falk C. Thiel

Protein Kinase A-induced tamoxifen resistance is mediated by anchoring protein AKAP13

• Open Access
• Research article

Cristiane Bentin Toaldo, Xanthippi Alexi, Karin Beelen, Marleen Kok, Michael Hauptmann, Maurice Jansen, Els Berns, Jacques Neefjes, Sabine Linn, Rob Michalides, Wilbert Zwart

Management of brain metastasis with magnetic resonance imaging and stereotactic irradiation attenuated benefits of prophylactic cranial irradiation in patients with limited-stage small cell lung cancer

• Open Access
• Research article

Yuichi Ozawa, Minako Omae, Masato Fujii, Takashi Matsui, Masato Kato, Shinya Sagisaka, Kazuhiro Asada, Masato Karayama, Toshihiro Shirai, Kazumasa Yasuda, Yutaro Nakamura, Naoki Inui, Kazunari Yamada, Koshi Yokomura, Takafumi Suda

YKL-40 regulated epithelial-mesenchymal transition and migration/invasion enhancement in non-small cell lung cancer

• Open Access
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Malvin Jefri, Yi-Ning Huang, Wen-Chien Huang, Chun-San Tai, Wen-Liang Chen

Essential medicines for breast cancer in low and middle income countries

• Open Access
• Research article

Y. T. Bazargani, A. de Boer, J. H. M. Schellens, H. G. M. Leufkens, Aukje K. Mantel-Teeuwisse

Efficacy of a brief manualized intervention Managing Cancer and Living Meaningfully (CALM) adapted to German cancer care settings: study protocol for a randomized controlled trial

• Open Access
• Study protocol

Katharina Scheffold, Rebecca Philipp, Dorit Engelmann, Frank Schulz-Kindermann, Christina Rosenberger, Karin Oechsle, Martin Härter, Karl Wegscheider, Florian Lordick, Chris Lo, Sarah Hales, Gary Rodin, Anja Mehnert

Early salpingectomy (TUbectomy) with delayed oophorectomy to improve quality of life as alternative for risk-reducing salpingo-oophorectomy in BRCA1/2 mutation carriers (TUBA study): a prospective non-randomised multicentre study

• Open Access
• Study protocol

Marline G. Harmsen, Marieke Arts-de Jong, Nicoline Hoogerbrugge, Angela H. E. M. Maas, Judith B. Prins, Johan Bulten, Steven Teerenstra, Eddy M. M. Adang, Jurgen M. J. Piek, Helena C van Doorn, Marc van Beurden, Marian J. E. Mourits, Ronald P. Zweemer, Katja N. Gaarenstroom, Brigitte F. M. Slangen, M. Caroline Vos, Luc R. C. W. van Lonkhuijzen, Leon F. A. G. Massuger, Rosella P. M. G. Hermens, Joanne A. de Hullu

Neutrophil count is associated with survival in localized prostate cancer

• Open Access
• Research article

Houda Bahig, Daniel Taussky, Guila Delouya, Amal Nadiri, Ariane Gagnon-Jacques, Paule Bodson-Clermont, Denis Soulieres

Berberine, a natural compound, suppresses Hedgehog signaling pathway activity and cancer growth

• Open Access
• Research article

Juan Wang, Yuanqiu Peng, Yuan Liu, Jun Yang, Ning Ding, Wenfu Tan

Erratum to: ComOn Coaching: study protocol of a randomized controlled trial to assess the effect of a varied number of coaching sessions on transfer into clinical practice following communication skills training

• Open Access
• Erratum

Marcelo Niglio de Figueiredo, Bärbel Rudolph, Carma L. Bylund, Tanja Goelz, Pia Heußner, Heribert Sattel, Kurt Fritzsche, Alexander Wuensch

Comparison of the prognosis and recurrence of apparent early-stage ovarian tumors treated with laparoscopy and laparotomy: a meta-analysis of clinical studies

• Open Access
• Research article

Ying Zhang, Shuying Fan, Yang Xiang, Hua Duan, Li Sun

Heterogeneity revealed through meta-analysis might link geographical differences with nasopharyngeal carcinoma incidence in Han Chinese populations

• Open Access
• Research article

Wen-Hui Su, Chi-Cking Chiu, Yin Yao Shugart

Selective repression of RET proto-oncogene in medullary thyroid carcinoma by a natural alkaloid berberine

• Open Access
• Research article

Vishnu Muthuraj Kumarasamy, Yoon-Joo Shin, John White, Daekyu Sun

Erratum to: The diagnostic challenge of pulmonary tumour thrombotic microangiopathy as a presentation for metastatic gastric cancer: A case report and review of the literature

• Open Access
• Erratum

Andrew L K Ho, Patryk Szulakowski, Waria H S Mohamid

A single-arm phase II trial of combined chemotherapy with S-1, oral leucovorin, and bevacizumab in heavily pre-treated patients with metastatic colorectal cancer

• Open Access
• Research article

Kazuhisa Yamaguchi, Hiroya Taniguchi, Azusa Komori, Yukiya Narita, Sohei Nitta, Motoo Nomura, Shigenori Kadowaki, Daisuke Takahari, Takashi Ura, Masashi Andoh, Kei Muro, Keita Mori, Yoshinori Igarashi

PATHOS: a phase II/III trial of risk-stratified, reduced intensity adjuvant treatment in patients undergoing transoral surgery for Human papillomavirus (HPV) positive oropharyngeal cancer

• Open Access
• Study protocol

Waheeda Owadally, Chris Hurt, Hayley Timmins, Emma Parsons, Sarah Townsend, Joanne Patterson, Katherine Hutcheson, Ned Powell, Matthew Beasley, Nachi Palaniappan, Max Robinson, Terence M. Jones, Mererid Evans

Over-expressing Akt in T cells to resist tumor immunosuppression and increase anti-tumor activity

• Open Access
• Research article

Yanhong Wu, Zhenling Deng, Yishu Tang, Shuren Zhang, Yu-Qian Zhang

The transcription factor ERG increases expression of neurotransmitter receptors on prostate cancer cells

• Open Access
• Research article

Haydn T. Kissick, Seung T. On, Laura K. Dunn, Martin G. Sanda, John M. Asara, Kathryn L. Pellegrini, Jonathan K. Noel, Mohamed S. Arredouani

Positive family history of colorectal cancer in a general practice setting [FRIDA.Frankfurt]: study protocol of a of a cross-sectional study

• Open Access
• Study protocol

Andrea Siebenhofer, Jasper Plath, Maja Taubenroth, Susanne Singer, Marlene Hechtner, Anne Dahlhaus, Sandra Rauck, Sylvia Schulz-Rothe, Insa Koné, Ferdinand M. Gerlach

Framing overdiagnosis in breast screening: a qualitative study with Australian experts

• Open Access
• Research article

Lisa M. Parker, Lucie Rychetnik, Stacy Carter

Cytokine serum levels during post-transplant adverse events in 61 pediatric patients after hematopoietic stem cell transplantation

• Open Access
• Research article

Michaela Döring, Karin Melanie Cabanillas Stanchi, Markus Mezger, Annika Erbacher, Judith Feucht, Matthias Pfeiffer, Peter Lang, Rupert Handgretinger, Ingo Müller

Incomplete Dll4/Notch signaling inhibition promotes functional angiogenesis supporting the growth of skin papillomas

• Open Access
• Research article

Dusan Djokovic, Alexandre Trindade, Joana Gigante, Mario Pinho, Adrian L. Harris, Antonio Duarte

Gamma tocotrienol targets tyrosine phosphatase SHP2 in mammospheres resulting in cell death through RAS/ERK pathway

• Open Access
• Research article

Wenyi Gu, Indira Prasadam, Meihua Yu, Fengxia Zhang, Patrick Ling, Yin Xiao, Chengzhong Yu

The value of completion axillary treatment in sentinel node positive breast cancer patients undergoing a mastectomy: a Dutch randomized controlled multicentre trial (BOOG 2013-07)

• Open Access
• Study protocol

L. M. van Roozendaal, J. HW de Wilt, T. van Dalen, J. A. van der Hage, L. JA Strobbe, L. J. Boersma, S. C. Linn, M. BI Lobbes, P. MP Poortmans, V. CG Tjan-Heijnen, K. KBT Van de Vijver, J. de Vries, A. H. Westenberg, A. GH Kessels, M. L. Smidt

Sulindac, 3,3’-diindolylmethane and curcumin reduce carcinogenesis in the Pirc rat, an Apc-driven model of colon carcinogenesis

• Open Access
• Research article

Angelo Pietro Femia, Paulo Victoria Soares, Cristina Luceri, Maura Lodovici, Augusto Giannini, Giovanna Caderni

Patterns of diagnostic imaging and associated radiation exposure among long-term survivors of young adult cancer: a population-based cohort study

• Open Access
• Research article

Corinne Daly, David R. Urbach, Thérèse A. Stukel, Paul C. Nathan, Wayne Deitel, Lawrence F. Paszat, Andrew S. Wilton, Nancy N. Baxter

Relationships between cancer pattern, country income and geographical region in Asia

• Open Access
• Research article

Chirk Jenn Ng, Chin Hai Teo, Nurdiana Abdullah, Wei Phin Tan, Hui Meng Tan

Patient-derived heavy chain antibody targets cell surface HSP90 on breast tumors

• Open Access
• Research article

Charan V. Devarakonda, Daniel Kita, Kathryn N. Phoenix, Kevin P. Claffey

Adjuvant therapy in the treatment of gallbladder cancer: a meta-analysis

• Open Access
• Research article

Ning Ma, Hui Cheng, Baodong Qin, Renqian Zhong, Bin Wang

An infant with hyperalertness, hyperkinesis, and failure to thrive: a rare diencephalic syndrome due to hypothalamic anaplastic astrocytoma

• Open Access
• Case report

Alessia Stival, Maurizio Lucchesi, Silvia Farina, Anna Maria Buccoliero, Francesca Castiglione, Lorenzo Genitori, Maurizio de Martino, Iacopo Sardi

Pre-treatment neutrophil-to-lymphocyte ratio is associated with neutrophil and T-cell infiltration and predicts clinical outcome in patients with glioblastoma

• Open Access
• Research article

Sheng Han, Yang Liu, Qingchang Li, Zhonghua Li, Haipei Hou, Anhua Wu

Exploring research participation among cancer patients: analysis of a national survey and an in-depth interview study

• Open Access
• Research article

Louise Mc Grath-Lone, Sophie Day, Claudia Schoenborn, Helen Ward

Physical Exercise Training versus Relaxation in Allogeneic stem cell transplantation (PETRA Study) – Rationale and design of a randomized trial to evaluate a yearlong exercise intervention on overall survival and side-effects after allogeneic stem cell transplantation

• Open Access
• Study protocol

Joachim Wiskemann, Rea Kuehl, Peter Dreger, Gerhard Huber, Nikolaus Kleindienst, Cornelia M. Ulrich, Martin Bohus

Neoadjuvant administration of Semliki Forest virus expressing interleukin-12 combined with attenuated Salmonella eradicates breast cancer metastasis and achieves long-term survival in immunocompetent mice

• Open Access
• Research article

M. Gabriela Kramer, Martín Masner, Erkuden Casales, María Moreno, Cristian Smerdou, José A. Chabalgoity

A novel somatic mutation in ACD induces telomere lengthening and apoptosis resistance in leukemia cells

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• Research article

Jean-François Spinella, Pauline Cassart, Nicolas Garnier, Philippe Rousseau, Claire Drullion, Chantal Richer, Manon Ouimet, Virginie Saillour, Jasmine Healy, Chantal Autexier, Daniel Sinnett

ER, PgR, Ki67, p27Kip1, and histological grade as predictors of pathological complete response in patients with HER2-positive breast cancer receiving neoadjuvant chemotherapy using taxanes followed by fluorouracil, epirubicin, and cyclophosphamide concomitant with trastuzumab

• Open Access
• Research article

Sasagu Kurozumi, Kenichi Inoue, Hiroyuki Takei, Hiroshi Matsumoto, Masafumi Kurosumi, Jun Horiguchi, Izumi Takeyoshi, Tetsunari Oyama

The bifunctional autophagic flux by 2-deoxyglucose to control survival or growth of prostate cancer cells

• Open Access
• Research article

Jeong Yong Jeon, Seung Won Kim, Ki Cheong Park, Mijin Yun

Case report of severe Cushing’s syndrome in medullary thyroid cancer complicated by functional diabetes insipidus, aortic dissection, jejunal intussusception, and paraneoplastic dysautonomia: remission with sorafenib without reduction in cortisol concentration

• Open Access
• Case report

Muhammad M. Hammami, Najla Duaiji, Ghazi Mutairi, Sabah Aklabi, Nasser Qattan, Mohei El-Din M. Abouzied, Mohamed W. Sous

Boronic prodrug of 4-hydroxytamoxifen is more efficacious than tamoxifen with enhanced bioavailability independent of CYP2D6 status

• Open Access
• Research article

Qiu Zhong, Changde Zhang, Qiang Zhang, Lucio Miele, Shilong Zheng, Guangdi Wang

Study protocol of the TRICOLORE trial: a randomized phase III study of oxaliplatin-based chemotherapy versus combination chemotherapy with S-1, irinotecan, and bevacizumab as first-line therapy for metastatic colorectal cancer

• Open Access
• Study protocol

Yoshito Komatsu, Chikashi Ishioka, Ken Shimada, Yasuhide Yamada, Makio Gamoh, Atsushi Sato, Tatsuro Yamaguchi, Satoshi Yuki, Satoshi Morita, Shin Takahashi, Rei Goto, Minoru Kurihara

Aspirin and P2Y12 inhibition attenuate platelet-induced ovarian cancer cell invasion

• Open Access
• Research article

Niamh M. Cooke, Cathy D. Spillane, Orla Sheils, John O’Leary, Dermot Kenny

DKK1 is a potential novel mediator of cisplatin-refractoriness in non-small cell lung cancer cell lines

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• Research article

Hogir Salim, Dali Zong, Petra Hååg, Metka Novak, Birgitta Mörk, Rolf Lewensohn, Lovisa Lundholm, Kristina Viktorsson

A randomized trial of a minimal intervention for sexual concerns after cancer: a comparison of self-help and professionally delivered modalities

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• Research article

Janette Perz, Jane M Ussher

The Deleted in Liver Cancer 1 (Dlc1) tumor suppressor is haploinsufficient for mammary gland development and epithelial cell polarity

• Open Access
• Research article

Pratima Basak, Rachelle Dillon, Heather Leslie, Afshin Raouf, Michael R. A. Mowat

S100A16 promotes differentiation and contributes to a less aggressive tumor phenotype in oral squamous cell carcinoma

• Open Access
• Research article

Dipak Sapkota, Ove Bruland, Himalaya Parajuli, Tarig A. Osman, Muy-Teck Teh, Anne C. Johannessen, Daniela Elena Costea

Effects of cytochalasin congeners, microtubule-directed agents, and doxorubicin alone or in combination against human ovarian carcinoma cell lines in vitro

• Open Access
• Research article

Matthew Trendowski, Timothy D. Christen, Christopher Acquafondata, Thomas P. Fondy

Optimizing the clinical utility of PCA3 to diagnose prostate cancer in initial prostate biopsy

• Open Access
• Research article

Jose Rubio-Briones, Angel Borque, Luis M. Esteban, Juan Casanova, Antonio Fernandez-Serra, Luis Rubio, Irene Casanova-Salas, Gerardo Sanz, Jose Domínguez-Escrig, Argimiro Collado, Alvaro Gómez-Ferrer, Inmaculada Iborra, Miguel Ramírez-Backhaus, Francisco Martínez, Ana Calatrava, Jose A. Lopez-Guerrero

Chemotherapy induces Notch1-dependent MRP1 up-regulation, inhibition of which sensitizes breast cancer cells to chemotherapy

• Open Access
• Research article

Baek Kim, Sam L. Stephen, Andrew M. Hanby, Kieran Horgan, Sarah L. Perry, Julie Richardson, Elizabeth A. Roundhill, Elizabeth M. A. Valleley, Eldo T. Verghese, Bethany J. Williams, James L. Thorne, Thomas A. Hughes

An early warning surveillance programme for detecting upper limb deterioration after treatment for breast cancer: A novel technology supported system

• Open Access
• Correspondence

Delva Shamley, Karen Robb

Size is an essential parameter in governing the UVB-protective efficacy of silver nanoparticles in human keratinocytes

• Open Access
• Research article

Rohan Palanki, Sumit Arora, Nikhil Tyagi, Lilia Rusu, Ajay P. Singh, Srinivas Palanki, James E. Carter, Seema Singh

Mitogen-activated protein kinase activator with WD40 repeats (MAWD) and MAWD-binding protein induce cell differentiation in gastric cancer

• Open Access
• Research article

Dongmei Li, Jun Zhang, Yu Xi, Lei Zhang, Wenmei Li, Jiantao Cui, Rui Xing, Yuanmin Pan, Zemin Pan, Feng Li, Youyong Lu

Coronin 2A (CRN5) expression is associated with colorectal adenoma-adenocarcinoma sequence and oncogenic signalling

• Open Access
• Research article

Raphael H. Rastetter, Margit Blömacher, Uta Drebber, Marija Marko, Juliane Behrens, Roxana Solga, Sarah Hojeili, Kurchi Bhattacharya, Claudia M. Wunderlich, F. Thomas Wunderlich, Margarete Odenthal, Anja Ziemann, Ludwig Eichinger, Christoph S. Clemen

An improved sequencing-based strategy to estimate locus-specific DNA methylation

• Open Access
• Technical advance

Giulia Brisotto, Alessandra di Gennaro, Valentina Damiano, Michela Armellin, Tiziana Perin, Roberta Maestro, Manuela Santarosa

Health related quality of life after oesophagectomy: elderly patients refer similar eating and swallowing difficulties than younger patients

• Open Access
• Research article

Francesco Cavallin, Eleonora Pinto, Luca M. Saadeh, Rita Alfieri, Matteo Cagol, Carlo Castoro, Marco Scarpa

Secreted frizzled-related protein promotors are hypermethylated in cutaneous squamous carcinoma compared with normal epidermis

• Open Access
• Research article

Junqin Liang, Xiaojing Kang, Yilinuer Halifu, Xuewen Zeng, Tianbo Jin, Mingxia Zhang, Dong Luo, Yuan Ding, Yunmin Zhou, Buwajier Yakeya, Dilinuer Abudu, Xiongming Pu

Effect of changes in treatment practice on survival for cervical cancer: results from a population-based study in Manitoba, Canada

• Open Access
• Research article

Yoon-Jung Kang, Dianne L. O’Connell, Robert Lotocki, Erich V. Kliewer, David E. Goldsbury, Alain A. Demers, Karen Canfell

Angiogenesis-related protein expression in bevacizumab-treated metastatic colorectal cancer: NOTCH1 detrimental to overall survival

• Open Access
• Research article

Tadeu Ferreira Paiva Jr., Victor Hugo Fonseca de Jesus, Raul Amorim Marques, Alexandre André Balieiro Anastácio da Costa, Mariana Petaccia de Macedo, Patricia Maria Peresi, Aline Damascena, Benedito Mauro Rossi, Maria Dirlei Begnami, Vladmir Cláudio Cordeiro de Lima

Expression profiling of O6 methylguanine-DNA-methyl transferase in prolactinomas: a correlative study of promoter methylation and pathological features in 136 cases

• Open Access
• Research article

Xiao-Bing Jiang, Bin Hu, Dong-Sheng He, Zhi-Gang Mao, Xin Wang, Bing-Bing Song, Yong-Hong Zhu, Hai-Jun Wang

Essential role of miR-200c in regulating self-renewal of breast cancer stem cells and their counterparts of mammary epithelium

• Open Access
• Research article

Zhong-Ming Feng, Jun Qiu, Xie-Wan Chen, Rong-Xia Liao, Xing-Yun Liao, Lu-Ping Zhang, Xu Chen, Yan Li, Zheng-Tang Chen, Jian-Guo Sun

OLIGOPELVIS – GETUG P07: a multicentre phase II trial of combined salvage radiotherapy and hormone therapy in oligometastatic pelvic node relapses of prostate cancer

• Open Access
• Study protocol

Stephane Supiot, Emmanuel Rio, Valérie Pacteau, Marie-Hélène Mauboussin, Loïc Campion, François Pein

Aberrant activation of NF-κB signaling in mammary epithelium leads to abnormal growth and ductal carcinoma in situ

• Open Access
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Whitney Barham, Lianyi Chen, Oleg Tikhomirov, Halina Onishko, Linda Gleaves, Thomas P. Stricker, Timothy S. Blackwell, Fiona E. Yull

Preoperative platelet-lymphocyte ratio is superior to neutrophil-lymphocyte ratio as a prognostic factor for soft-tissue sarcoma

• Open Access
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Yi Que, Haibo Qiu, Yuanfang Li, Yongming Chen, Wei Xiao, Zhiwei Zhou, Xing Zhang

Functional analyses of ATM, ATR and Fanconi anemia proteins in lung carcinoma

• Open Access
• Research article

Jan H. Beumer, Katherine Y. Fu, Bean N. Anyang, Jill M. Siegfried, Christopher J. Bakkenist

Label-free blood serum detection by using surface-enhanced Raman spectroscopy and support vector machine for the preoperative diagnosis of parotid gland tumors

• Open Access
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Bing Yan, Bo Li, Zhining Wen, Xianyang Luo, Lili Xue, Longjiang Li

Attitudes and practice patterns for maintaining relative dose intensity of chemotherapy in outpatient clinics: results of a Japanese web-based survey

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Hitomi Sakai, Noriyuki Katsumata, Genmu Kadokura

The effects of short-term fasting on tolerance to (neo) adjuvant chemotherapy in HER2-negative breast cancer patients: a randomized pilot study

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• Research article

Stefanie de Groot, Maaike PG Vreeswijk, Marij JP Welters, Gido Gravesteijn, Jan JWA Boei, Anouk Jochems, Daniel Houtsma, Hein Putter, Jacobus JM van der Hoeven, Johan WR Nortier, Hanno Pijl, Judith R Kroep

A randomized phase II study of weekly nab-paclitaxel plus gemcitabine or simplified LV5FU2 as first-line therapy in patients with metastatic pancreatic cancer: the AFUGEM GERCOR trial

• Open Access
• Study protocol

Jean-Baptiste Bachet, Benoist Chibaudel, Franck Bonnetain, Pierre Validire, Pascal Hammel, Thierry André, Christophe Louvet

Evaluation of an assay for methylated BCAT1 and IKZF1 in plasma for detection of colorectal neoplasia

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Susanne K. Pedersen, Erin L. Symonds, Rohan T. Baker, David H. Murray, Aidan McEvoy, Sascha C. Van Doorn, Marco W. Mundt, Stephen R. Cole, Geetha Gopalsamy, Dileep Mangira, Lawrence C. LaPointe, Evelien Dekker, Graeme P. Young

High expression of AGR2 in lung cancer is predictive of poor survival

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Mohammed Alavi, Vei Mah, Erin L. Maresh, Lora Bagryanova, Steve Horvath, David Chia, Lee Goodglick, Alvin Y. Liu

Combination of Iodine-125 brachytherapy and chemotherapy for locally recurrent stage III non-small cell lung cancer after concurrent chemoradiotherapy

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Xiaojuan Yu, Jin Li, Xiaoming Zhong, Jingdong He

Lipid peroxidation and glutathione peroxidase activity relationship in breast cancer depends on functional polymorphism of GPX1

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Ewa Jablonska, Jolanta Gromadzinska, Beata Peplonska, Wojciech Fendler, Edyta Reszka, Magdalena B. Krol, Edyta Wieczorek, Agnieszka Bukowska, Peter Gresner, Michal Galicki, Oskar Zambrano Quispe, Zbigniew Morawiec, Wojciech Wasowicz

Erratum to: NAT1 and NAT2 genetic polymorphisms and environmental exposure as risk factors for oesophageal squamous cell carcinoma: a case-control study

• Open Access
• Erratum

Marco Matejcic, Matjaz Vogelsang, Yabing Wang, M Iqbal Parker

Tumour biology, metastatic sites and taxanes sensitivity as determinants of eribulin mesylate efficacy in breast cancer: results from the ERIBEX retrospective, international, multicenter study

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Mélodie Dell’Ova, Eléonora De Maio, Séverine Guiu, Lise Roca, Florence Dalenc, Anna Durigova, Frédéric Pinguet, Khedidja Bekhtari, William Jacot, Stéphane Pouderoux

RECK is not an independent prognostic marker for breast cancer

• Open Access
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Luciana R. Gomes, André Fujita, Joni D. Mott, Fernando A. Soares, Leticia Labriola, Mari C. Sogayar

Regulation of IL-8 gene expression in gliomas by microRNA miR-93

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Enrica Fabbri, Eleonora Brognara, Giulia Montagner, Claudio Ghimenton, Albino Eccher, Cinzia Cantù, Susanna Khalil, Valentino Bezzerri, Lisa Provezza, Nicoletta Bianchi, Alessia Finotti, Monica Borgatti, Giuseppe Moretto, Marco Chilosi, Giulio Cabrini, Roberto Gambari

Agreement between MRI and pathologic breast tumor size after neoadjuvant chemotherapy, and comparison with alternative tests: individual patient data meta-analysis

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Michael L. Marinovich, Petra Macaskill, Les Irwig, Francesco Sardanelli, Eleftherios Mamounas, Gunter von Minckwitz, Valentina Guarneri, Savannah C. Partridge, Frances C. Wright, Jae Hyuck Choi, Madhumita Bhattacharyya, Laura Martincich, Eren Yeh, Viviana Londero, Nehmat Houssami

Inhibition of IGF1-R overcomes IGFBP7-induced chemotherapy resistance in T-ALL

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Isabelle Bartram, Ulrike Erben, Jutta Ortiz-Tanchez, Katja Blunert, Cornelia Schlee, Martin Neumann, Sandra Heesch, Claudia D. Baldus

The dog as a naturally-occurring model for insulin-like growth factor type 1 receptor-overexpressing breast cancer: an observational cohort study

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Laetitia Jaillardon, Jérome Abadie, Tiffanie Godard, Mario Campone, Delphine Loussouarn, Brigitte Siliart, Frédérique Nguyen

Upregulation of MicroRNA-19b predicts good prognosis in patients with hepatocellular carcinoma presenting with vascular invasion or multifocal disease

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Chung-Lin Hung, Chia-Shen Yen, Hung-Wen Tsai, Yu-Chieh Su, Chia-Jui Yen

40 years of progress in female cancer death risk: a Bayesian spatio-temporal mapping analysis in Switzerland

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Christian Herrmann, Silvia Ess, Beat Thürlimann, Nicole Probst-Hensch, Penelope Vounatsou

Phase II clinical trial of sorafenib plus interferon-alpha treatment for patients with metastatic renal cell carcinoma in Japan

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Masatoshi Eto, Yoshiaki Kawano, Yoshihiko Hirao, Koji Mita, Yoichi Arai, Taiji Tsukamoto, Katsuyoshi Hashine, Akio Matsubara, Tomoaki Fujioka, Go Kimura, Nobuo Shinohara, Katsunori Tatsugami, Shiro Hinotsu, Seiji Naito

Burkitt lymphoma beyond MYC translocation: N-MYC and DNA methyltransferases dysregulation

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Giulia De Falco, Maria Raffaella Ambrosio, Fabio Fuligni, Anna Onnis, Cristiana Bellan, Bruno Jim Rocca, Mohsen Navari, Maryam Etebari, Lucia Mundo, Sara Gazaneo, Fabio Facchetti, Stefano A. Pileri, Lorenzo Leoncini, Pier Paolo Piccaluga

Assessment of DNA methylation profiling and copy number variation as indications of clonal relationship in ipsilateral and contralateral breast cancers to distinguish recurrent breast cancer from a second primary tumour

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Katie T. Huang, Thomas Mikeska, Jason Li, Elena A. Takano, Ewan K A Millar, Peter H. Graham, Samantha E. Boyle, Ian G. Campbell, Terence P. Speed, Alexander Dobrovic, Stephen B. Fox

The effect of pre-diagnostic vitamin D supplementation on cancer survival in women: a cohort study within the UK Clinical Practice Research Datalink

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Mona Jeffreys, Maria Theresa Redaniel, Richard M. Martin

Evaluation of health benefits and harms of the breast cancer screening programme in the Basque Country using discrete event simulation

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Arantzazu Arrospide, Montserrat Rue, Nicolien T. van Ravesteyn, Merce Comas, Nerea Larrañaga, Garbiñe Sarriugarte, Javier Mar

Epigenetic-based combinatorial resveratrol and pterostilbene alters DNA damage response by affecting SIRT1 and DNMT enzyme expression, including SIRT1-dependent γ-H2AX and telomerase regulation in triple-negative breast cancer

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Rishabh Kala, Harsh N. Shah, Samantha L. Martin, Trygve O. Tollefsbol

Enhancement of Cetuximab-Induced Radiosensitization by JAK-1 Inhibition

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James A. Bonner, Hoa Q. Trummell, Andrew B. Bonner, Christopher D. Willey, Markus Bredel, Eddy S. Yang

Assessment and model guided cancer screening promotion by village doctors in China: a randomized controlled trial protocol

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• Study protocol

Rui Feng, Xingrong Shen, Jing Chai, Penglai Chen, Jing Cheng, Han Liang, Ting Zhao, Rui Sha, Kaichun Li, Debin Wang

Small ubiquitin-related modifier 2/3 interacts with p65 and stabilizes it in the cytoplasm in HBV-associated hepatocellular carcinoma

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Jun Liu, Manqi Sha, Qianfeng Wang, Yong Ma, Xiaoping Geng, Yufeng Gao, Lijie Feng, Yujun Shen, Yuxian Shen

c-MET immunostaining in colorectal carcinoma is associated with local disease recurrence

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Jaudah Al-Maghrabi, Eman Emam, Wafaey Gomaa, Moaath Saggaf, Abdelbaset Buhmeida, Mohammad Al-Qahtani, Mahmoud Al-Ahwal

Head and neck cancer: metronomic chemotherapy

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Francesca De Felice, Daniela Musio, Vincenzo Tombolini

Establishment of monoclonal HCC cell lines with organ site-specific tropisms

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Jinliang Wan, Duo Wen, Lili Dong, Jun Tang, Dongli Liu, Yang Liu, Zhonghua Tao, Dongmei Gao, Huichuan Sun, Ya Cao, Jia Fan, Weizhong Wu

CA1 contributes to microcalcification and tumourigenesis in breast cancer

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Yabing Zheng, Bing Xu, Yan Zhao, He Gu, Chang Li, Yao Wang, Xiaotian Chang

The combined risks of reduced or increased function variants in cell death pathway genes differentially influence cervical cancer risk and herpes simplex virus type 2 infection among black Africans and the Mixed Ancestry population of South Africa

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Koushik Chattopadhyay, Anna-Lise Williamson, Annapurna Hazra, Collet Dandara

AKAP3 correlates with triple negative status and disease free survival in breast cancer

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Rezvan Esmaeili, Keivan Majidzadeh-A, Leila Farahmand, Maryam Ghasemi, Malihe Salehi, Ali Reza Khoshdel

Hesperidin inhibits HeLa cell proliferation through apoptosis mediated by endoplasmic reticulum stress pathways and cell cycle arrest

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Yaoxian Wang, Hui Yu, Jin Zhang, Jing Gao, Xin Ge, Ge Lou

Frequent down-regulation of ABC transporter genes in prostate cancer

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Rita Demidenko, Deividas Razanauskas, Kristina Daniunaite, Juozas Rimantas Lazutka, Feliksas Jankevicius, Sonata Jarmalaite

PRIMA-1MET induces death in soft-tissue sarcomas cell independent of p53

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Thomas Grellety, Audrey Laroche-Clary, Vanessa Chaire, Pauline Lagarde, Frédéric Chibon, Agnes Neuville, Antoine Italiano

NKTR-102 Efficacy versus irinotecan in a mouse model of brain metastases of breast cancer

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Chris E. Adkins, Mohamed I. Nounou, Tanvirul Hye, Afroz S. Mohammad, Tori Terrell-Hall, Neel K. Mohan, Michael A. Eldon, Ute Hoch, Paul R. Lockman

Do Multidisciplinary Team (MDT) processes influence survival in patients with colorectal cancer? A population-based experience

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Alastair Munro, Mhari Brown, Paddy Niblock, Robert Steele, Frank Carey

High PHLPP expression is associated with better prognosis in patients with resected lung adenocarcinoma

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Dongqing Lv, Haihua Yang, Wei Wang, Youyou Xie, Wei Hu, Minhua Ye, Xiaofeng Chen

Representativeness of breast cancer cases in an integrated health care delivery system

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Scarlett Lin Gomez, Salma Shariff-Marco, Julie Von Behren, Marilyn L. Kwan, Candyce H. Kroenke, Theresa H. M. Keegan, Peggy Reynolds, Lawrence H. Kushi

Postoperative complications affect early recurrence of hepatocellular carcinoma after curative resection

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Yan-Ming Zhou, Xiao-Feng Zhang, Bin Li, Cheng-Jun Sui, Jia-Mei Yang

Prognostic influence of body mass index and body weight gain during adjuvant FOLFOX chemotherapy in Korean colorectal cancer patients

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Dae-Won Lee, Sae-Won Han, Yongjun Cha, Kyung-Hun Lee, Tae-Yong Kim, Do-Youn Oh, Seock-Ah Im, Yung-Jue Bang, Ji Won Park, Seung-Bum Ryoo, Seung-Yong Jeong, Gyeong Hoon Kang, Kyu Joo Park, Tae-You Kim

Effect of a group educational intervention on rural Chinese women’s knowledge and attitudes about human papillomavirus (HPV) and HPV vaccines

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Jing Li, Le-Ni Kang, Bayi Li, Yi Pang, Rong Huang, You-Lin Qiao

Everolimus restrains the paracrine pro-osteoclast activity of breast cancer cells

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Valeria Simone, Sabino Ciavarella, Oronzo Brunetti, Annalisa Savonarola, Mauro Cives, Marco Tucci, Giuseppina Opinto, Eugenio Maiorano, Franco Silvestris

Capecitabine in combination with either cisplatin or weekly paclitaxel as a first-line treatment for metastatic esophageal squamous cell carcinoma: a randomized phase II study

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Su Jin Lee, Sungmin Kim, Moonjin Kim, Jeeyun Lee, Yeon Hee Park, Young-Hyuck Im, Se Hoon Park

Development of novel real-time PCR methodology for quantification of COL11A1 mRNA variants and evaluation in breast cancer tissue specimens

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Makrina Karaglani, Ioannis Toumpoulis, Nikolaos Goutas, Nikoleta Poumpouridou, Dimitrios Vlachodimitropoulos, Spyridon Vasilaros, Ioannis Rizos, Christos Kroupis

Multicenter Phase II study of FOLFOX or biweekly XELOX and Erbitux (cetuximab) as first-line therapy in patients with wild-type KRAS/BRAF metastatic colorectal cancer: The FLEET study

• Open Access
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Hitoshi Soda, Hiromichi Maeda, Junichi Hasegawa, Takao Takahashi, Shoichi Hazama, Mutsumi Fukunaga, Emiko Kono, Masahito Kotaka, Junichi Sakamoto, Naoki Nagata, Koji Oba, Hideyuki Mishima

Multiple primary malignancies involving lung cancer

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Feng Li, Wen-Zhao Zhong, Fei-Yu Niu, Ning Zhao, Jin-Ji Yang, Hong-Hong Yan, Yi-Long Wu

Immunohistochemical subtypes predict the clinical outcome in high-risk node-negative breast cancer patients treated with adjuvant FEC regimen: results of a single-center retrospective study

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S. Rahal, J M Boher, J M Extra, C. Tarpin, E. Charafe-Jauffret, E. Lambaudie, R. Sabatier, J. Thomassin-Piana, A. Tallet, M. Resbeut, G. Houvenaeghel, L. Laborde, F. Bertucci, P. Viens, A. Gonçalves

Differences in clinical importance of Bcl-2 in breast cancer according to hormone receptors status or adjuvant endocrine therapy

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Naoko Honma, Rie Horii, Yoshinori Ito, Shigehira Saji, Mamoun Younes, Takuji Iwase, Futoshi Akiyama

Prognostic significance of proline, glutamic acid, leucine rich protein 1 (PELP1) in triple-negative breast cancer: a retrospective study on 129 cases

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Yanzhi Zhang, Jiali Dai, Keely M. McNamara, Bing Bai, Mumu Shi, Monica S. M. Chan, Ming Liu, Hironobu Sasano, Xiuli Wang, Xiaolei Li, Lijuan Liu, Ying Ma, Shuwen Cao, Yanchun Xing, Baoshan Zhao, Yinli Song, Lin Wang

Efficacy of trabectedin in malignant solitary fibrous tumors: a retrospective analysis from the French Sarcoma Group

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J. Khalifa, M. Ouali, L. Chaltiel, S. Le Guellec, A. Le Cesne, J-Y Blay, P. Cousin, L. Chaigneau, E. Bompas, S. Piperno-Neumann, B. Bui-Nguyen, M. Rios, J-P Delord, N. Penel, C. Chevreau

Critical role of CDK11p58 in human breast cancer growth and angiogenesis

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Yayun Chi, Sheng Huang, Haojie Peng, Mengying Liu, Jun Zhao, Zhiming Shao, Jiong Wu

Estrogen-mediated inactivation of FOXO3a by the G protein-coupled estrogen receptor GPER

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Erin Zekas, Eric R. Prossnitz

Serum CD26 levels in patients with gastric cancer: a novel potential diagnostic marker

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Virginia Boccardi, Luigi Marano, Rosaria Rita Amalia Rossetti, Maria Rosaria Rizzo, Natale di Martino, Giuseppe Paolisso

Isolation of vaccinia JX594 from pustules following therapy for hepatocellular carcinoma

• Open Access
• Case report

Che-Hsuan Kung, Shu-Chen Kuo, Te-Li Chen, Wen-Sung Weng

Cost-effectiveness simulation and analysis of colorectal cancer screening in Hong Kong Chinese population: comparison amongst colonoscopy, guaiac and immunologic fecal occult blood testing

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Carlos KH Wong, Cindy LK Lam, YF Wan, Daniel YT Fong

MiR-449a suppresses the epithelial-mesenchymal transition and metastasis of hepatocellular carcinoma by multiple targets

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Shu-peng Chen, Bao-xin Liu, Jie Xu, Xiao-feng Pei, Yi-ji Liao, Feng Yuan, Fang Zheng

Transarterial injection of recombinant human type-5 adenovirus H101 in combination with transarterial chemoembolization (TACE) improves overall and progressive-free survival in unresectable hepatocellular carcinoma (HCC)

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Xiao-jun Lin, Qi-jiong Li, Xiang-ming Lao, Han Yang, Sheng-ping Li

Improving immunological tumor microenvironment using electro-hyperthermia followed by dendritic cell immunotherapy

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Yuk-Wah Tsang, Cheng-Chung Huang, Kai-Lin Yang, Mau-Shin Chi, Hsin-Chien Chiang, Yu-Shan Wang, Gabor Andocs, Andras Szasz, Wen-Tyng Li, Kwan-Hwa Chi

Investigation of the feasibility of elective irradiation to neck level Ib using intensity-modulated radiotherapy for patients with nasopharyngeal carcinoma: a retrospective analysis

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Fan Zhang, Yi-Kan Cheng, Wen-Fei Li, Rui Guo, Lei Chen, Ying Sun, Yan-Ping Mao, Guan-Qun Zhou, Xu Liu, Li-Zhi Liu, Ai-Hua Lin, Ling-Long Tang, Jun Ma

Impact of a nutrition and physical activity intervention (ENRICH: Exercise and Nutrition Routine Improving Cancer Health) on health behaviors of cancer survivors and carers: a pragmatic randomized controlled trial

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E. L. James, F. G. Stacey, K. Chapman, A. W. Boyes, T. Burrows, A. Girgis, G. Asprey, A. Bisquera, D. R. Lubans

Prior oral contraceptive use in ovarian cancer patients: assessing associations with overall and progression-free survival

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Aminah Jatoi, Nathan R. Foster, Kimberly R. Kalli, Robert A. Vierkant, Zhiying Zhang, Melissa C. Larson, Brooke Fridley, Ellen L. Goode

Hypoxia alters the recruitment of tropomyosins into the actin stress fibres of neuroblastoma cells

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Joshua J. Glass, Phoebe A. Phillips, Peter W. Gunning, Justine R. Stehn

Retreatment with anti-EGFR based therapies in metastatic colorectal cancer: impact of intervening time interval and prior anti-EGFR response

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X. Liu, G. C. George, A. M. Tsimberidou, A. Naing, J. J. Wheler, S. Kopetz, S. Fu, S. A. Piha-Paul, C. Eng, G. S. Falchook, F. Janku, C. Garrett, D. Karp, R. Kurzrock, R. Zinner, K. Raghav, V. Subbiah, K. Hess, F. Meric-Bernstam, D. S. Hong, M. J. Overman

Gene expression and splicing alterations analyzed by high throughput RNA sequencing of chronic lymphocytic leukemia specimens

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Wei Liao, Gwen Jordaan, Phillipp Nham, Ryan T. Phan, Matteo Pelegrini, Sanjai Sharma

Consolidation chemotherapy may improve survival for patients with locally advanced non-small-cell lung cancer receiving concurrent chemoradiotherapy - retrospective analysis of 203 cases

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Lipin Liu, Nan Bi, Zhe Ji, Junling Li, Jingbo Wang, Xiaozhen Wang, Zhouguang Hui, Jima Lv, Jun Liang, Zongmei Zhou, Yan Wang, Weibo Yin, Luhua Wang

Oncolytic adenovirus targeting cyclin E overexpression repressed tumor growth in syngeneic immunocompetent mice

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Pei-Hsin Cheng, Xiao-Mei Rao, Stephen L. Wechman, Xiao-Feng Li, Kelly M. McMasters, Heshan Sam Zhou

The existence of Th22, pure Th17 and Th1 cells in CIN and Cervical Cancer along with their frequency variation in different stages of cervical cancer

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Wenjing Zhang, Xinli Tian, Fidia Mumtahana, Jun Jiao, Teng Zhang, Kimiko Della Croce, Daoxin Ma, Beihua Kong, Baoxia Cui

Construction of possible integrated predictive index based on EGFR and ANXA3 polymorphisms for chemotherapy response in fluoropyrimidine-treated Japanese gastric cancer patients using a bioinformatic method

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Hiro Takahashi, Nahoko Kaniwa, Yoshiro Saito, Kimie Sai, Tetsuya Hamaguchi, Kuniaki Shirao, Yasuhiro Shimada, Yasuhiro Matsumura, Atsushi Ohtsu, Takayuki Yoshino, Toshihiko Doi, Anna Takahashi, Yoko Odaka, Misuzu Okuyama, Jun-ichi Sawada, Hiromi Sakamoto, Teruhiko Yoshida

No evidence for a decreased risk of thyroid cancer in association with use of metformin or other antidiabetic drugs: a case-control study

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Claudia Becker, Susan S. Jick, Christoph R. Meier, Michael Bodmer

Metabolic syndrome and the risk of urothelial carcinoma of the bladder: a case-control study

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Maurizio Montella, Matteo Di Maso, Anna Crispo, Maria Grimaldi, Cristina Bosetti, Federica Turati, Aldo Giudice, Massimo Libra, Diego Serraino, Carlo La Vecchia, Rosa Tambaro, Ernesta Cavalcanti, Gennaro Ciliberto, Jerry Polesel

Clinical and pathological significance of ROS1 expression in intrahepatic cholangiocarcinoma

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Kyung-Hun Lee, Kyoung-Bun Lee, Tae-Yong Kim, Sae-Won Han, Do-Youn Oh, Seock-Ah Im, Tae-You Kim, Nam-Joon Yi, Kwang-Woong Lee, Kyung-Suk Suh, Ja-June Jang, Yung-Jue Bang

P38 MAPK expression and activation predicts failure of response to CHOP in patients with Diffuse Large B-Cell Lymphoma

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Gabriel G. Vega, Alejandro Avilés-Salas, J. Ramón Chalapud, Melisa Martinez-Paniagua, Rosana Pelayo, Héctor Mayani, Rogelio Hernandez-Pando, Otoniel Martinez-Maza, Sara Huerta-Yepez, Benjamin Bonavida, Mario I. Vega

Vulnerability in elderly patients with gastrointestinal cancer – translation, cultural adaptation and validation of the European Portuguese version of the Vulnerable Elders Survey (VES-13)

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F. Carneiro, N. Sousa, LF Azevedo, D. Saliba

A case of simultaneous occurrence of acute myeloid leukemia and multiple myeloma

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• Case report

Wang Lu-qun, Li Hao, Li Xiang-xin, Li Fang-lin, Wang Ling-ling, Chen Xue-liang, Hou Ming

CYP39A1 polymorphism is associated with toxicity during intensive induction chemotherapy in patients with advanced head and neck cancer

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Thomas Melchardt, Clemens Hufnagl, Teresa Magnes, Lukas Weiss, Georg Hutarew, Daniel Neureiter, Alexander Schlattau, Gerhard Moser, Alexander Gaggl, Wolfgang Tränkenschuh, Richard Greil, Alexander Egle

Up-regulation of HER2 by gemcitabine enhances the antitumor effect of combined gemcitabine and trastuzumab emtansine treatment on pancreatic ductal adenocarcinoma cells

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Shin Kan, Shigeo Koido, Masato Okamoto, Kazumi Hayashi, Masaki Ito, Yuko Kamata, Hideo Komita, Eijiro Nagasaki, Sadamu Homma

Clinicopathological and prognostic significance of FOXP3+ tumor infiltrating lymphocytes in patients with breast cancer: a meta-analysis

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Daqing Jiang, Zhaohua Gao, Zhengang Cai, Meixian Wang, Jianjun He

Status epilepticus associated with platinum chemotherapy in a patient with cervical cancer: a case report

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• Case report

Laura L. Holman, Yulan Ren, Shannon N. Westin

The autophagy GABARAPL1 gene is epigenetically regulated in breast cancer models

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Eric Hervouet, Aurore Claude-Taupin, Thierry Gauthier, Valérie Perez, Annick Fraichard, Pascale Adami, Gilles Despouy, Franck Monnien, Marie-Paule Algros, Michèle Jouvenot, Régis Delage-Mourroux, Michaël Boyer-Guittaut

Expression of Oct3/4 and Nanog in the head and neck squamous carcinoma cells and its clinical implications for delayed neck metastasis in stage I/II oral tongue squamous cell carcinoma

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Noboru Habu, Yorihisa Imanishi, Kaori Kameyama, Masayuki Shimoda, Yutaka Tokumaru, Koji Sakamoto, Ryoichi Fujii, Seiji Shigetomi, Kuninori Otsuka, Yoichiro Sato, Yoshihiro Watanabe, Hiroyuki Ozawa, Toshiki Tomita, Masato Fujii, Kaoru Ogawa

The regulatory and predictive functions of miR-17 and miR-92 families on cisplatin resistance of non-small cell lung cancer

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Jian Zhao, Wenfan Fu, Hongying Liao, Lu Dai, Zeyong Jiang, Youguang Pan, Haoda Huang, Yijun Mo, Siwen Li, Guangping Yang, Jun Yin

Relapsing pneumonitis due to two distinct inhibitors of the MAPK/ERK pathway: report of a case

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• Case report

Violaine Giraud, Christine Longvert, Solène Houlle-Crepin, Claire Danel, Sylvie Labrune, Philippe Camus, Philippe Saiag, Thierry Chinet

Coffee consumption and the risk of gastric cancer: a meta-analysis of prospective cohort studies

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Liqing Li, Yong Gan, Chunmei Wu, Xianguo Qu, Gang Sun, Zuxun Lu

The adherence paradox: guideline deviations contribute to the increased 5-year survival of breast cancer patients

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Christian O. Jacke, Ute S. Albert, Matthias Kalder

A case–control study of sporadic retinoblastoma in relation to maternal health conditions and reproductive factors: a report from the Children’s Oncology group

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Julia E. Heck, Negar Omidakhsh, Saeedeh Azary, Beate Ritz, Ondine S. von Ehrenstein, Greta R. Bunin, Arupa Ganguly

DNA hypermethylation and decreased mRNA expression of MAL, PRIMA1, PTGDR and SFRP1 in colorectal adenoma and cancer

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Alexandra Kalmár, Bálint Péterfia, Péter Hollósi, Orsolya Galamb, Sándor Spisák, Barnabás Wichmann, András Bodor, Kinga Tóth, Árpád V. Patai, Gábor Valcz, Zsófia Brigitta Nagy, Vivien Kubák, Zsolt Tulassay, Ilona Kovalszky, Béla Molnár

The human complement inhibitor Sushi Domain-Containing Protein 4 (SUSD4) expression in tumor cells and infiltrating T cells is associated with better prognosis of breast cancer patients

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Emelie Englund, Bart Reitsma, Ben C. King, Astrid Escudero-Esparza, Sioned Owen, Akira Orimo, Marcin Okroj, Lola Anagnostaki, Wen G. Jiang, Karin Jirström, Anna M. Blom

The Aplidin analogs PM01215 and PM02781 inhibit angiogenesis in vitro and in vivo

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Bojana Borjan, Normann Steiner, Silvia Karbon, Johann Kern, Andrés Francesch, Martin Hermann, Wolfgang Willenbacher, Eberhard Gunsilius, Gerold Untergasser

Genomic profile predicts the efficacy of neoadjuvant chemotherapy for cervical cancer patients

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Naoki Horikawa, Tsukasa Baba, Noriomi Matsumura, Ryusuke Murakami, Kaoru Abiko, Junzo Hamanishi, Ken Yamaguchi, Masafumi Koshiyama, Yumiko Yoshioka, Ikuo Konishi

Feasibility study of docetaxel plus bevacizumab as first line therapy for elderly patients with advanced non-small-cell lung cancer: Thoracic Oncology Research Group (TORG) 1014

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Yusuke Takagi, Yukio Hosomi, Fumihiro Oshita, Hiroaki Okamoto, Nobuhiko Seki, Koichi Minato, Hiromi Aono, Kouzo Yamada, Yusuke Okuma, Naoya Hida, Takahiko Sakamoto, Yosuke Miura, Makiko Yomota, Akira Satoh, Hideo Kunitoh, Kentaro Sakamaki, Masahiko Shibuya, Koshiro Watanabe

The role of communication in breast cancer screening: a qualitative study with Australian experts

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Lisa M. Parker, Lucie Rychetnik, Stacy M. Carter

Heparan sulfate proteoglycans undergo differential expression alterations in right sided colorectal cancer, depending on their metastatic character

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Iván Fernández-Vega, Olivia García-Suárez, Beatriz García, Ainara Crespo, Aurora Astudillo, Luis M. Quirós

Preoperative neutrophil-to-lymphocyte ratio is an independent prognostic marker in patients with laryngeal squamous cell carcinoma

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Xiu-Ping Tu, Qian-Hui Qiu, Liang-Si Chen, Xiao-Ning Luo, Zhong-Ming Lu, Si-Yi Zhang, Shao-Hua Chen

Factors that influence persistence or recurrence of high-grade squamous intraepithelial lesion with positive margins after the loop electrosurgical excision procedure: a retrospective study

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Menghan Zhu, Yuan He, Jan PA Baak, Xianrong Zhou, Yuqing Qu, Long Sui, Weiwei Feng, Qing Wang

The influence of orthopedic corsets on the incidence of pathological fractures in patients with spinal bone metastases after radiotherapy

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Harald Rief, Robert Förster, Stefan Rieken, Thomas Bruckner, Ingmar Schlampp, Tilman Bostel, Jürgen Debus

Stomatin-like protein 2 is overexpressed in epithelial ovarian cancer and predicts poor patient survival

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Fei Sun, Wen Ding, Jie-Hua He, Xiao-Jing Wang, Ze-Biao Ma, Yan-Fang Li

Exploratory biomarker analysis for treatment response in KRAS wild type metastatic colorectal cancer patients who received cetuximab plus irinotecan

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Seung Tae Kim, Tae Jin Ahn, Eunjin Lee, In-Gu Do, Su Jin Lee, Se Hoon Park, Joon Oh Park, Young Suk Park, Ho Yeong Lim, Won Ki Kang, Suk Hyeong Kim, Jeeyun Lee, Hee Cheol Kim

miR-320b suppresses cell proliferation by targeting c-Myc in human colorectal cancer cells

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Hantao Wang, Fuao Cao, Xu Li, Hua Miao, Jifu E, Junjie Xing, Chuan-gang Fu

Correlation between apparent diffusion coefficients and HER2 status in gastric cancers: pilot study

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Jian He, Hua Shi, Zhuping Zhou, Jun Chen, Wenxian Guan, Hao Wang, Haiping Yu, Song Liu, Zhengyang Zhou, Xiaofeng Yang, Tian Liu

Reduced toxicity in the treatment of locally advanced rectal cancer: a comparison of volumetric modulated arc therapy and 3D conformal radiotherapy

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Leif Hendrik Dröge, Hanne Elisabeth Weber, Manuel Guhlich, Martin Leu, Lena-Christin Conradi, Jochen Gaedcke, Steffen Hennies, Markus Karl Herrmann, Margret Rave-Fränk, Hendrik Andreas Wolff

Endometriosis as a risk factor for ovarian or endometrial cancer — results of a hospital-based case–control study

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Stefanie Burghaus, Lothar Häberle, Michael G. Schrauder, Katharina Heusinger, Falk C. Thiel, Alexander Hein, David Wachter, Johanna Strehl, Arndt Hartmann, Arif B. Ekici, Stefan P. Renner, Matthias W. Beckmann, Peter A. Fasching

Ifosfamide-loaded poly (lactic-co-glycolic acid) PLGA-dextran polymeric nanoparticles to improve the antitumor efficacy in Osteosarcoma

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Bin Chen, Jie-Zuan Yang, Li-Feng Wang, Yi-Jun Zhang, Xiang-Jin Lin

Incidence of prostate and urological cancers in England by ethnic group, 2001-2007: a descriptive study

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Mahiben Maruthappu, Isobel Barnes, Shameq Sayeed, Raghib Ali

Impact of liver cirrhosis due to chronic hepatitis C viral infection on the outcome of ovarian cancer: a prospective study

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Basel Refky, Sherif Kotb, Tamer Fady, Ahmad Marwan, Doaa Abd El-Khalek, Waleed Elnahas, Mohamed T. Hafez, Eduard Malik, Amr A. Soliman

Evaluation of BRCA1-related molecular features and microRNAs as prognostic factors for triple negative breast cancers

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Meriem Boukerroucha, Claire Josse, Sonia ElGuendi, Bouchra Boujemla, Pierre Frères, Raphaël Marée, Stephane Wenric, Karin Segers, Joelle Collignon, Guy Jerusalem, Vincent Bours

Hypermethylation of the GATA binding protein 4 (GATA4) promoter in Chinese pediatric acute myeloid leukemia

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Yan-Fang Tao, Fang Fang, Shao-Yan Hu, Jun Lu, Lan Cao, Wen-Li Zhao, Pei-Fang Xiao, Zhi-Heng Li, Na-Na Wang, Li-Xiao Xu, Xiao-Juan Du, Li-Chao Sun, Yan-Hong Li, Yi-Ping Li, Yun-Yun Xu, Jian Ni, Jian Wang, Xing Feng, Jian Pan

Association between shift work and the risk of death from biliary tract cancer in Japanese men

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Yingsong Lin, Takeshi Nishiyama, Michiko Kurosawa, Akiko Tamakoshi, Tatsuhiko Kubo, Yoshihisa Fujino, Shogo Kikuchi

Evaluation of the prognostic impact of postoperative adjuvant radiotherapy on head and neck mucosal melanoma: a meta-analysis

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Wei Li, Yalian Yu, Hailong Wang, Aihui Yan, Xuejun Jiang

Downregulation of programmed cell death 10 is associated with tumor cell proliferation, hyperangiogenesis and peritumoral edema in human glioblastoma

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Nicole Lambertz, Nicolai El Hindy, Ilonka Kreitschmann-Andermahr, Klaus Peter Stein, Philipp Dammann, Neriman Oezkan, Oliver Mueller, Ulrich Sure, Yuan Zhu

Does anti-p53 antibody status predict for clinical outcomes in metastatic colorectal cancer patients treated with fluoropyrimidine, oxaliplatin, plus bevacizumab as first-line chemotherapy?

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Hiroki Osumi, Eiji Shinozaki, Mitsukuni Suenaga, Yosuke Kumekawa, Mariko Ogura, Masato Ozaka, Satoshi Matsusaka, Keisho Chin, Noriko Yamamoto, Nobuyuki Mizunuma

Oxalate induces breast cancer

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Andrés M. Castellaro, Alfredo Tonda, Hugo H. Cejas, Héctor Ferreyra, Beatriz L. Caputto, Oscar A. Pucci, German A. Gil

Regulation of cellular sphingosine-1-phosphate by sphingosine kinase 1 and sphingosine-1-phopshate lyase determines chemotherapy resistance in gastroesophageal cancer

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Kasia Matula, Elaina Collie-Duguid, Graeme Murray, Khyati Parikh, Heike Grabsch, Patrick Tan, Salina Lalwani, Roberta Garau, Yuhan Ong, Gillian Bain, Asa-Dahle Smith, Gordon Urquhart, Jacek Bielawski, Michael Finnegan, Russell Petty

Randomized phase II study of paclitaxel/carboplatin intercalated with gefitinib compared to paclitaxel/carboplatin alone for chemotherapy-naïve non-small cell lung cancer in a clinically selected population excluding patients with non-smoking adenocarcinoma or mutated EGFR

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Yoon Ji Choi, Dae Ho Lee, Chang Min Choi, Jung Shin Lee, Seung Jin Lee, Jin-Hee Ahn, Sang-We Kim

Bevacizumab and Combination Chemotherapy in rectal cancer Until Surgery (BACCHUS): a phase II, multicentre, open-label, randomised study of neoadjuvant chemotherapy alone in patients with high-risk cancer of the rectum

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• Study protocol

R. Glynne-Jones, N. Hava, V. Goh, S. Bosompem, J. Bridgewater, I. Chau, A. Gaya, H. Wasan, B. Moran, L. Melcher, A. MacDonald, M. Osborne, S. Beare, M. Jitlal, A. Lopes, M. Hall, N. West, P. Quirke, Wai-Lup Wong, M. Harrison

A randomized controlled trial of web-based cognitive behavioral therapy for severely fatigued breast cancer survivors (CHANGE-study): study protocol

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• Study protocol

H. J. G. Abrahams, M. F. M. Gielissen, M. M. Goedendorp, T. Berends, M. E. W. J. Peters, H. Poort, C. A. H. H. V. M. Verhagen, H. Knoop

The prognostic value of CXC-chemokine receptor 2 (CXCR2) in gastric cancer patients

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Zhenglin Wang, Hao Liu, Zhenbin Shen, Xuefei Wang, Heng Zhang, Jing Qin, Jiejie Xu, Yihong Sun, Xinyu Qin

Organ Preservation in Rectal Adenocarcinoma: a phase II randomized controlled trial evaluating 3-year disease-free survival in patients with locally advanced rectal cancer treated with chemoradiation plus induction or consolidation chemotherapy, and total mesorectal excision or nonoperative management

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• Study protocol

J. Joshua Smith, Oliver S. Chow, Marc J. Gollub, Garrett M. Nash, Larissa K. Temple, Martin R. Weiser, José G. Guillem, Philip B. Paty, Karin Avila, Julio Garcia-Aguilar

Molecular mechanism of anti-cancer activity of phycocyanin in triple-negative breast cancer cells

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Mathangi Ravi, Shilpa Tentu, Ganga Baskar, Surabhi Rohan Prasad, Swetha Raghavan, Prajisha Jayaprakash, Jeyaraman Jeyakanthan, Suresh K Rayala, Ganesh Venkatraman

Cross platform analysis of methylation, miRNA and stem cell gene expression data in germ cell tumors highlights characteristic differences by tumor histology

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Jenny N. Poynter, Jessica R. B. M. Bestrashniy, Kevin A. T. Silverstein, Anthony J. Hooten, Christopher Lees, Julie A. Ross, Jakub Tolar

The NF-κB p65 and p50 homodimer cooperate with IRF8 to activate iNOS transcription

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Priscilla S. Simon, Sarah K. Sharman, Chunwan Lu, Dafeng Yang, Amy V. Paschall, Sidhartha S. Tulachan, Kebin Liu

Management and treatment of relapsed or refractory Ph(−) B-precursor ALL: a web-based, double-blind survey of EU clinicians

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Deborah Saltman, Arie Barlev, Divyagiri Seshagiri, Ioannis Katsoulis, Vincent Lin, Beth Barber

Colorectal liver metastatic disease: efficacy of irreversible electroporation—a single-arm phase II clinical trial (COLDFIRE-2 trial)

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• Study protocol

Hester J. Scheffer, Laurien G P H Vroomen, Karin Nielsen, Aukje A J M van Tilborg, Emile F I Comans, Cornelis van Kuijk, Bram B. van der Meijs, Janneke van den Bergh, Petrousjka M P van den Tol, Martijn R. Meijerink

Whole exome sequencing of microdissected splenic marginal zone lymphoma: a study to discover novel tumor-specific mutations

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Jan Peveling-Oberhag, Franziska Wolters, Claudia Döring, Dirk Walter, Ludger Sellmann, René Scholtysik, Marco Lucioni, Max Schubach, Marco Paulli, Saskia Biskup, Stefan Zeuzem, Ralf Küppers, Martin-Leo Hansmann

Small nucleolar RNA U91 is a new internal control for accurate microRNAs quantification in pancreatic cancer

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Alexey Popov, Arpad Szabo, Václav Mandys

Association of activated Gαq to the tumor suppressor Fhit is enhanced by phospholipase Cβ

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Hao Zuo, Yung H. Wong

Association between praziquantel treatment and cholangiocarcinoma: a hospital-based matched case–control study

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Supot Kamsa-ard, Vor Luvira, Ake Pugkhem, Varisara Luvira, Bandit Thinkhamrop, Krittika Suwanrungruang, Vajarabhongsa Bhudhisawasdi

TrkA is amplified in malignant melanoma patients and induces an anti-proliferative response in cell lines

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Luigi Pasini, Angela Re, Toma Tebaldi, Gianluca Ricci, Sebastiana Boi, Valentina Adami, Mattia Barbareschi, Alessandro Quattrone

Transcriptional profiles of pilocytic astrocytoma are related to their three different locations, but not to radiological tumor features

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Krzysztof Zakrzewski, Michał Jarząb, Aleksandra Pfeifer, Małgorzata Oczko-Wojciechowska, Barbara Jarząb, Paweł P. Liberski, Magdalena Zakrzewska

Clinical detection and categorization of uncommon and concomitant mutations involving BRAF

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Gang Zheng, Li-Hui Tseng, Guoli Chen, Lisa Haley, Peter Illei, Christopher D. Gocke, James R. Eshleman, Ming-Tseh Lin

KIT exon 10 variant (c.1621 A > C) single nucleotide polymorphism as predictor of GIST patient outcome

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Mehdi Brahmi, Laurent Alberti, Armelle Dufresne, Isabelle Ray-Coquard, Philippe Cassier, Pierre Meeus, Anne-Valérie Decouvelaere, Dominique Ranchère-Vince, Jean-Yves Blay

Ambulatory Medical Assistance - After Cancer (AMA-AC): A model for an early trajectory survivorship survey of lymphoma patients treated with anthracycline-based chemotherapy

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Gisèle Compaci, Manuela Rueter, Sébastien Lamy, Lucie Oberic, Christian Recher, Maryse Lapeyre-Mestre, Guy Laurent, Fabien Despas

Prognostic significance of Epstein-Barr virus infection in gastric cancer: a meta-analysis

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Xuechao Liu, Jianjun Liu, Haibo Qiu, Pengfei Kong, Shangxiang Chen, Wei Li, Youqing Zhan, Yuanfang Li, Yingbo Chen, Zhiwei Zhou, Dazhi Xu, Xiaowei Sun

The inflammatory milieu within the pancreatic cancer microenvironment correlates with clinicopathologic parameters, chemoresistance and survival

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Daniel Delitto, Brian S. Black, Heather L. Sorenson, Andrea E. Knowlton, Ryan M. Thomas, George A. Sarosi, Lyle L. Moldawer, Kevin E. Behrns, Chen Liu, Thomas J. George, Jose G. Trevino, Shannon M. Wallet, Steven J. Hughes

Cancer-testis antigen cyclin A1 is broadly expressed in ovarian cancer and is associated with prolonged time to tumor progression after platinum-based therapy

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Ruza Arsenic, Elena Ilona Braicu, Anne Letsch, Manfred Dietel, Jalid Sehouli, Ulrich Keilholz, Sebastian Ochsenreither

Putative stem cell markers in cervical squamous cell carcinoma are correlated with poor clinical outcome

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Teng Hou, Weijing Zhang, Chongjie Tong, Gallina Kazobinka, Xin Huang, Yongwen Huang, Yanna Zhang

Capecitabine and oxaliplatin combined with bevacizumab are feasible for treating selected Japanese patients at least 75 years of age with metastatic colorectal cancer

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Yoshinori Munemoto, Mitsuro Kanda, Keiichiro Ishibashi, Taishi Hata, Michiya Kobayashi, Junichi Hasegawa, Mutsumi Fukunaga, Akinori Takagane, Toshio Otsuji, Yasuhiro Miyake, Michitaka Nagase, Junichi Sakamoto, Masaki Matsuoka, Koji Oba, Hideyuki Mishima

Patterns of resource utilization and cost for postmenopausal women with hormone-receptor–positive, human epidermal growth factor receptor-2–negative advanced breast cancer in Europe

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Guy Jerusalem, Patrick Neven, Nina Marinsek, Jie Zhang, Ravi Degun, Giancarlo Benelli, Stephen Saletan, Jean-François Ricci, Fabrice Andre

Hypercalcemia in metastatic GIST caused by systemic elevated calcitriol: a case report and review of the literature

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• Case report

Katrine Hygum, Christian Nielsen Wulff, Torben Harsløf, Anders Kindberg Boysen, Philip Blach Rossen, Bente Lomholt Langdahl, Akmal Ahmed Safwat

Demethylation of HIN-1 reverses paclitaxel-resistance of ovarian clear cell carcinoma through the AKT-mTOR signaling pathway

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Chih-Ming Ho, Chi-Jung Huang, Shih-Hung Huang, Shwu-Fen Chang, Wen-Fang Cheng

Prognostic significance of macrophage invasion in hilar cholangiocarcinoma

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Georgi Atanasov, Hans-Michael Hau, Corinna Dietel, Christian Benzing, Felix Krenzien, Andreas Brandl, Georg Wiltberger, Ivan Matia, Isabel Prager, Katrin Schierle, Simon C. Robson, Anja Reutzel-Selke, Johann Pratschke, Moritz Schmelzle, Sven Jonas

The unique transcriptional response produced by concurrent estrogen and progesterone treatment in breast cancer cells results in upregulation of growth factor pathways and switching from a Luminal A to a Basal-like subtype

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Eleanor F. Need, Luke A. Selth, Andrew P. Trotta, Damien A. Leach, Lauren Giorgio, Melissa A. O’Loughlin, Eric Smith, Peter G. Gill, Wendy V. Ingman, J. Dinny Graham, Grant Buchanan

Can Peto’s paradox be used as the null hypothesis to identify the role of evolution in natural resistance to cancer? A critical review

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Hugo Ducasse, Beata Ujvari, Eric Solary, Marion Vittecoq, Audrey Arnal, Florence Bernex, Nelly Pirot, Dorothée Misse, François Bonhomme, François Renaud, Frédéric Thomas, Benjamin Roche

Tumorigenic hybrids between mesenchymal stem cells and gastric cancer cells enhanced cancer proliferation, migration and stemness

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Jianguo Xue, Yuan Zhu, Zixuan Sun, Runbi Ji, Xu Zhang, Wenrong Xu, Xiao Yuan, Bin Zhang, Yongmin Yan, Lei Yin, Huijuan Xu, Leilei Zhang, Wei Zhu, Hui Qian

Prognostic significance of Traf2- and Nck- interacting kinase (TNIK) in colorectal cancer

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Hidenori Takahashi, Toshiaki Ishikawa, Megumi Ishiguro, Satoshi Okazaki, Kaoru Mogushi, Hirotoshi Kobayashi, Satoru Iida, Hiroshi Mizushima, Hiroshi Tanaka, Hiroyuki Uetake, Kenichi Sugihara

Inhibition of autophagy exerts anti-colon cancer effects via apoptosis induced by p53 activation and ER stress

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Kosuke Sakitani, Yoshihiro Hirata, Yohko Hikiba, Yoku Hayakawa, Sozaburo Ihara, Hirobumi Suzuki, Nobumi Suzuki, Takako Serizawa, Hiroto Kinoshita, Kei Sakamoto, Hayato Nakagawa, Keisuke Tateishi, Shin Maeda, Tsuneo Ikenoue, Shoji Kawazu, Kazuhiko Koike

Abnormalities in the meibomian glands in patients with oral administration of anticancer combination drug-capsule TS-1®: a case report

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• Case report

Shin Mizoguchi, Yuka Okada, Masahide Kokado, Shizuya Saika

Circulating tumor cells (CTC) and KRAS mutant circulating free DNA (cfDNA) detection in peripheral blood as biomarkers in patients diagnosed with exocrine pancreatic cancer

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Julie Earl, Sandra Garcia-Nieto, Jose Carlos Martinez-Avila, José Montans, Alfonso Sanjuanbenito, Mercedes Rodríguez-Garrote, Eduardo Lisa, Elena Mendía, Eduardo Lobo, Núria Malats, Alfredo Carrato, Carmen Guillen-Ponce

Non-participation in breast cancer screening for women with chronic diseases and multimorbidity: a population-based cohort study

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L. F. Jensen, A. F. Pedersen, B. Andersen, M. Vestergaard, P. Vedsted

The postoperative patient-reported quality of recovery in colorectal cancer patients under enhanced recovery after surgery using QoR-40

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Dai Shida, Kotaro Wakamatsu, Yuu Tanaka, Atsushi Yoshimura, Masahiko Kawaguchi, Sachio Miyamoto, Kyoko Tagawa

E2-EPF UCP regulates stability and functions of missense mutant pVHL via ubiquitin mediated proteolysis

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Kyeong-Su Park, Ju Hee Kim, Hee Won Shin, Kyung-Sook Chung, Dong-Soo Im, Jung Hwa Lim, Cho-Rok Jung

Lysine-specific demethylase 5C promotes hepatocellular carcinoma cell invasion through inhibition BMP7 expression

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Xuening Ji, Shi Jin, Xiaotong Qu, Kejun Li, Hongjiang Wang, Hui He, Fuchao Guo, Lei Dong

Phase II trial of selective internal radiation therapy and systemic chemotherapy for liver-predominant metastases from pancreatic adenocarcinoma

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Peter Gibbs, Cuong Do, Lara Lipton, David N. Cade, Michael J. Tapner, David Price, Geoff D. Bower, Richard Dowling, Meir Lichtenstein, Guy A. van Hazel

Gene expression profiling analysis of CRTC1-MAML2 fusion oncogene-induced transcriptional program in human mucoepidermoid carcinoma cells

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Jie Chen, Jian-Liang Li, Zirong Chen, James D. Griffin, Lizi Wu

Elevated expression of HSP90 and the antitumor effect of an HSP90 inhibitor via inactivation of the Akt/mTOR pathway in undifferentiated pleomorphic sarcoma

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Hirofumi Bekki, Kenichi Kohashi, Akira Maekawa, Yuichi Yamada, Hidetaka Yamamoto, Katsumi Harimaya, Michiyuki Hakozaki, Kazuki Nabeshima, Yukihide Iwamoto, Yoshinao Oda

Hypoxia biomarkers in squamous cell carcinoma of the uterine cervix

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Christine Ellingsen, Lise Mari K. Andersen, Kanthi Galappathi, Einar K. Rofstad

Current opinion on the role of testosterone in the development of prostate cancer: a dynamic model

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• Hypothesis

Xiaohui Xu, Xinguang Chen, Hui Hu, Amy B. Dailey, Brandie D. Taylor

Benzofuroxan derivatives N-Br and N-I induce intrinsic apoptosis in melanoma cells by regulating AKT/BIM signaling and display anti metastatic activity in vivo

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C. F. Farias, M. H. Massaoka, N. Girola, R. A. Azevedo, A. K. Ferreira, S. D. Jorge, L. C. Tavares, C. R. Figueiredo, L. R. Travassos

Prediction of response to anti-EGFR antibody-based therapies by multigene sequencing in colorectal cancer patients

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Laura Lupini, Cristian Bassi, Jitka Mlcochova, Gentian Musa, Marta Russo, Petra Vychytilova-Faltejskova, Marek Svoboda, Silvia Sabbioni, Radim Nemecek, Ondrej Slaby, Massimo Negrini

Prognostic value of inhibitors of apoptosis proteins (IAPs) and caspases in prostate cancer: caspase-3 forms and XIAP predict biochemical progression after radical prostatectomy

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Gonzalo Rodríguez-Berriguete, Norelia Torrealba, Miguel Angel Ortega, Pilar Martínez-Onsurbe, Gabriel Olmedilla, Ricardo Paniagua, Manuel Guil-Cid, Benito Fraile, Mar Royuela

Propensity-matched analysis of three different chemotherapy sequences in patients with locoregionally advanced nasopharyngeal carcinoma treated using intensity-modulated radiotherapy

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Wen-Fei Li, Ying-Qin Li, Lei Chen, Yuan Zhang, Rui Guo, Fan Zhang, Hao Peng, Ying Sun, Jun Ma

Stem cell protein Piwil1 endowed endometrial cancer cells with stem-like properties via inducing epithelial-mesenchymal transition

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Zheng Chen, Qi Che, Xiaoying He, Fangyuan Wang, Huihui Wang, Minjiao Zhu, Jing Sun, Xiaoping Wan

Predicting the response of patients with advanced urothelial cancer to methotrexate, vinblastine, Adriamycin, and cisplatin (MVAC) after the failure of gemcitabine and platinum (GP)

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Ki Hong Kim, Sung Joon Hong, Kyung Seok Han

Long-term results of chemoradiotherapy for stage II-III thoracic esophageal cancer in a single institution after 2000 -with a focus on comparison of three protocols-

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Rei Umezawa, Keiichi Jingu, Haruo Matsushita, Toshiyuki Sugawara, Masaki Kubozono, Takaya Yamamoto, Yojiro Ishikawa, Maiko Kozumi, Noriyoshi Takahashi, Yu Katagiri, Noriyuki Kadoya, Ken Takeda, Hisanori Ariga, Kenji Nemoto, Shogo Yamada

Incarvine C suppresses proliferation and vasculogenic mimicry of hepatocellular carcinoma cells via targeting ROCK inhibition

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Ji-Gang Zhang, Dan-Dan Zhang, Xin Wu, Yu-Zhu Wang, Sheng-Ying Gu, Guan-Hua Zhu, Xiao-Yu Li, Qin Li, Gao-Lin Liu

The importance of extranodal extension in penile cancer: a meta-analysis

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Zhi-Ling Zhang, Chun-Ping Yu, Zhuo-Wei Liu, Liliya Velet, Yong-Hong Li, Li-Juan Jiang, Fang-Jian Zhou

Exploring DNA methylation changes in promoter, intragenic, and intergenic regions as early and late events in breast cancer formation

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Garth H. Rauscher, Jacob K. Kresovich, Matthew Poulin, Liying Yan, Virgilia Macias, Abeer M. Mahmoud, Umaima Al-Alem, Andre Kajdacsy-Balla, Elizabeth L. Wiley, Debra Tonetti, Melanie Ehrlich

Suppression of Homologous Recombination by insulin-like growth factor-1 inhibition sensitizes cancer cells to PARP inhibitors

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Oreekha Amin, Marie-Claude Beauchamp, Paul Abou Nader, Ido Laskov, Sanaa Iqbal, Charles-André Philip, Amber Yasmeen, Walter H. Gotlieb

microRNA-145 promotes differentiation in human urothelial carcinoma through down-regulation of syndecan-1

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Tomomi Fujii, Keiji Shimada, Yoshihiro Tatsumi, Kinta Hatakeyama, Chiho Obayashi, Kiyohide Fujimoto, Noboru Konishi

Performance of the colorectal cancer screening marker Sept9 is influenced by age, diabetes and arthritis: a nested case–control study

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Mai-Britt W. Ørntoft, Hans J. Nielsen, Torben F. Ørntoft, Claus L. Andersen

For which cancers might patients benefit most from expedited symptomatic diagnosis? Construction of a ranking order by a modified Delphi technique

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Willie Hamilton, Sally Stapley, Christine Campbell, Georgios Lyratzopoulos, Greg Rubin, Richard D. Neal

Downregulation of toll-like receptor 4 induces suppressive effects on hepatitis B virus-related hepatocellular carcinoma via ERK1/2 signaling

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Yiting Wang, Jing Cai, Xiaoli Zeng, Yajie Chen, Wei Yan, Yuming Ouyang, Dan Xiao, Zhiming Zeng, Long Huang, Anwen Liu

Surgery time interval and molecular subtype may influence Ki67 change after core needle biopsy in breast cancer patients

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Xiaosong Chen, Siji Zhu, Xiaochun Fei, David H. Garfield, Jiayi Wu, Ou Huang, Yafen Li, Li Zhu, Jianrong He, Weiguo Chen, Xiaolong Jin, Kunwei Shen

Leukocyte telomere length and its association with mammographic density and proliferative diagnosis among women undergoing diagnostic image-guided breast biopsy

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Clara Bodelon, Christopher M. Heaphy, Alan K. Meeker, Berta Geller, Pamela M. Vacek, Donald L. Weaver, Rachael E. Chicoine, John A. Shepherd, Amir Pasha Mahmoudzadeh, Deesha A. Patel, Louise A. Brinton, Mark E. Sherman, Gretchen L. Gierach

Methylation status of TSHr in well-differentiated thyroid cancer by using cytologic material

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Kinyas Kartal, Sevgen Onder, Kemal Kosemehmetoglu, Sadettin Kilickap, Yesim Gaye Tezel, Volkan Kaynaroglu

NDN and CD1A are novel prognostic methylation markers in patients with head and neck squamous carcinomas

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Shama Virani, Emily Bellile, Carol R. Bradford, Thomas E. Carey, Douglas B. Chepeha, Justin A. Colacino, Joseph I. Helman, Jonathan B. McHugh, Lisa A. Peterson, Maureen A. Sartor, Jeremy MG Taylor, Heather M. Walline, Greg T. Wolf, Laura S. Rozek

Comparative analysis of 14-3-3 isoform expression and epigenetic alterations in colorectal cancer

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Gavin M. Young, Vijayababu M. Radhakrishnan, Sara M. Centuori, Cecil J. Gomes, Jesse D. Martinez

Population attributable risks of oral cavity cancer to behavioral and medical risk factors in France: results of a large population-based case–control study, the ICARE study

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Loredana Radoï, Gwenn Menvielle, Diane Cyr, Bénédicte Lapôtre-Ledoux, Isabelle Stücker, Danièle Luce

Microarray profiling shows distinct differences between primary tumors and commonly used preclinical models in hepatocellular carcinoma

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Weining Wang, N. Gopalakrishna Iyer, Hsien Ts’ung Tay, Yonghui Wu, Tony K. H. Lim, Lin Zheng, In Chin Song, Chee Keong Kwoh, Hung Huynh, Patrick O. B. Tan, Pierce K. H. Chow

Breast cancer metastasis suppressor 1 (BRMS1) attenuates TGF-β1-induced breast cancer cell aggressiveness through downregulating HIF-1α expression

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Kyung Hwa Cho, Seong-Lan Yu, Do Yeun Cho, Chang Gyo Park, Hoi Young Lee

Higher proliferation of peritumoral endothelial cells to IL-6/sIL-6R than tumoral endothelial cells in hepatocellular carcinoma

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Peng-Yuan Zhuang, Jian-Dong Wang, Zhao-Hui Tang, Xue-Ping Zhou, Zhi-Wei Quan, Ying-Bin Liu, Jun Shen

Cholelithiasis and the risk of intrahepatic cholangiocarcinoma: a meta-analysis of observational studies

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Hao Cai, Wen-Tao Kong, Chao-Bo Chen, Guo-Ming Shi, Cheng Huang, Ying-Hao Shen, Hui-Chuan Sun

A Her2-let-7-β2-AR circuit affects prognosis in patients with Her2-positive breast cancer

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Dan Liu, Que Deng, Limin Sun, Tao Wang, Zhengyan Yang, Hongyu Chen, Liang Guo, Yanjun Liu, Yuanfang Ma, Ning Guo, Ming Shi

High SLFN11 expression predicts better survival for patients with KRAS exon 2 wild type colorectal cancer after treated with adjuvant oxaliplatin-based treatment

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Yanhong Deng, Yue Cai, Yan Huang, Zihuan Yang, Yang Bai, Yanlu Liu, Xiuping Deng, Jianping Wang

The effects of pulmonary diseases on histologic types of lung cancer in both sexes: a population-based study in Taiwan

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Jing-Yang Huang, Zhi-Hong Jian, Oswald Ndi Nfor, Wen-Yuan Ku, Pei-Chieh Ko, Chia-Chi Lung, Chien-Chang Ho, Hui-Hsien Pan, Chieh-Ying Huang, Yu-Chiu Liang, Yung-Po Liaw

Reprogramming energy metabolism and inducing angiogenesis: co-expression of monocarboxylate transporters with VEGF family members in cervical adenocarcinomas

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Céline Pinheiro, Eduardo A. Garcia, Filipa Morais-Santos, Marise A. R. Moreira, Fábio M. Almeida, Luiz F. Jubé, Geraldo S. Queiroz, Élbio C. Paula, Maria A. Andreoli, Luisa L. Villa, Adhemar Longatto-Filho, Fátima Baltazar

Toremifene, a selective estrogen receptor modulator, significantly improved biochemical recurrence in bone metastatic prostate cancer: a randomized controlled phase II a trial

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Tetsuya Fujimura, Satoru Takahashi, Haruki Kume, Tomohiko Urano, Kenichi Takayama, Yuta Yamada, Motofumi Suzuki, Hiroshi Fukuhara, Tohru Nakagawa, Satoshi Inoue, Yukio Homma

Risk of fracture in men with prostate cancer on androgen deprivation therapy: a population-based cohort study in New Zealand

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Alice Wang, Zuzana Obertová, Charis Brown, Nishi Karunasinghe, Karen Bishop, Lynnette Ferguson, Ross Lawrenson

Targeting glycolysis by 3-bromopyruvate improves tamoxifen cytotoxicity of breast cancer cell lines

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Yasmin M. Attia, Hanan S. EL-Abhar, Mahmoud M. Al Marzabani, Samia A. Shouman

Analysis of the expression of Kv10.1 potassium channel in patients with brain metastases and glioblastoma multiforme: impact on survival

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Ramón Martínez, Walter Stühmer, Sabine Martin, Julian Schell, Andrea Reichmann, Veit Rohde, Luis Pardo

High infiltration of mast cells positive to tryptase predicts worse outcome following resection of colorectal liver metastases

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Shinsuke Suzuki, Yasushi Ichikawa, Kazuya Nakagawa, Takafumi Kumamoto, Ryutaro Mori, Ryusei Matsuyama, Kazuhisa Takeda, Mitsuyoshi Ota, Kuniya Tanaka, Tomohiko Tamura, Itaru Endo

Advantages of a next generation sequencing targeted approach for the molecular diagnosis of retinoblastoma

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Simona Grotta, Gemma D’Elia, Rossana Scavelli, Silvia Genovese, Cecilia Surace, Pietro Sirleto, Raffaele Cozza, Antonino Romanzo, Maria Antonietta De Ioris, Paola Valente, Anna Cristina Tomaiuolo, Francesca Romana Lepri, Tiziana Franchin, Laura Ciocca, Serena Russo, Franco Locatelli, Adriano Angioni

From prospective biobanking to precision medicine: BIO-RAIDs – an EU study protocol in cervical cancer

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• Study protocol

Charlotte Ngo, Sanne Samuels, Ksenia Bagrintseva, Andrea Slocker, Philippe Hupé, Gemma Kenter, Marina Popovic, Nina Samet, Patricia Tresca, Heiko von der Leyen, Eric Deutsch, Roman Rouzier, Lisa Belin, Maud Kamal, Suzy Scholl

Macrophage migration inhibitory factor - a therapeutic target in gallbladder cancer

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Tejaswini Subbannayya, Pamela Leal-Rojas, Mustafa A. Barbhuiya, Remya Raja, Santosh Renuse, Gajanan Sathe, Sneha M. Pinto, Nazia Syed, Vishalakshi Nanjappa, Arun H. Patil, Patricia Garcia, Nandini A. Sahasrabuddhe, Bipin Nair, Rafael Guerrero-Preston, Sanjay Navani, Pramod K. Tiwari, Vani Santosh, David Sidransky, T. S. Keshava Prasad, Harsha Gowda, Juan Carlos Roa, Akhilesh Pandey, Aditi Chatterjee

Multimodality imaging with CT, MR and FDG-PET for radiotherapy target volume delineation in oropharyngeal squamous cell carcinoma

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David Bird, Andrew F. Scarsbrook, Jonathan Sykes, Satiavani Ramasamy, Manil Subesinghe, Brendan Carey, Daniel J. Wilson, Neil Roberts, Gary McDermott, Ebru Karakaya, Evrim Bayman, Mehmet Sen, Richard Speight, Robin J.D. Prestwich

A novel aspirin prodrug inhibits NFκB activity and breast cancer stem cell properties

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Irida Kastrati, Vladislav A. Litosh, Shuangping Zhao, Manuel Alvarez, Gregory R. J. Thatcher, Jonna Frasor

Prolonged use of human insulin increases breast cancer risk in Taiwanese women with type 2 diabetes

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Chin-Hsiao Tseng

Completeness of T, N, M and stage grouping for all cancers in the Mallorca Cancer Registry

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M. Ramos, P. Franch, M. Zaforteza, J. Artero, M. Durán

Feasibility and accuracy evaluation of three human papillomavirus assays for FTA card-based sampling: a pilot study in cervical cancer screening

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Shao-Ming Wang, Shang-Ying Hu, Wen Chen, Feng Chen, Fang-Hui Zhao, Wei He, Xin-Ming Ma, Yu-Qing Zhang, Jian Wang, Priya Sivasubramaniam, You-Lin Qiao

Women’s experience with home-based self-sampling for human papillomavirus testing

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Farhana Sultana, Robyn Mullins, Dallas R. English, Julie A. Simpson, Kelly T. Drennan, Stella Heley, C. David Wrede, Julia M. L. Brotherton, Marion Saville, Dorota M. Gertig

The impact of comorbid disease history on all-cause and cancer-specific mortality in myeloid leukemia and myeloma – a Swedish population-based study

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Mohammad Mohammadi, Yang Cao, Ingrid Glimelius, Matteo Bottai, Sandra Eloranta, Karin E. Smedby

Outcome of vulvar reconstruction in patients with advanced and recurrent vulvar malignancies

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Wei Zhang, Ang Zeng, Jiaxin Yang, Dongyan Cao, Xiaodong He, Xiaojun Wang, Yan You, Jie Chen, Jinghe Lang, Keng Shen

Cancer incidence in patients with type 2 diabetes mellitus: a population-based cohort study in Shanghai

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Hui-Lin Xu, Hong Fang, Wang-Hong Xu, Guo-You Qin, Yu-Jie Yan, Bao-Dong Yao, Nai-Qing Zhao, Yi-Nan Liu, Fen Zhang, Wei-Xi Li, Na Wang, Jie Zhou, Jin-Ling Zhang, Li-Yun Zhao, Lun-Qiang Li, Yan-Ping Zhao

Prediction of survival prognosis after surgery in patients with symptomatic metastatic spinal cord compression from non-small cell lung cancer

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Mingxing Lei, Yaosheng Liu, Chuanghao Tang, Shaoxing Yang, Shubin Liu, Shiguo Zhou

Off-label use of targeted therapies in osteosarcomas: data from the French registry OUTC’S (Observatoire de l’Utilisation des Thérapies Ciblées dans les Sarcomes)

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Mathilde Penel-Page, Isabelle Ray-Coquard, Julie Larcade, Magali Girodet, Laure Bouclier, Muriel Rogasik, Nadège Corradini, Natacha Entz-Werle, Laurence Brugieres, Julien Domont, Cyril Lervat, Sophie Piperno-Neumann, Helène Pacquement, Jacques-Olivier Bay, Jean-Claude Gentet, Antoine Thyss, Loic Chaigneau, Bérangère Narciso, Helène Cornille, Jean-Yves Blay, Perrine Marec-Bérard

EIF2A-dependent translational arrest protects leukemia cells from the energetic stress induced by NAMPT inhibition

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Chiara Zucal, Vito G. D’Agostino, Antonio Casini, Barbara Mantelli, Natthakan Thongon, Debora Soncini, Irene Caffa, Michele Cea, Alberto Ballestrero, Alessandro Quattrone, Stefano Indraccolo, Alessio Nencioni, Alessandro Provenzani

A prospective study on histone γ-H2AX and 53BP1 foci expression in rectal carcinoma patients: correlation with radiation therapy-induced outcome

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Cholpon S. Djuzenova, Marcus Zimmermann, Astrid Katzer, Vanessa Fiedler, Luitpold V. Distel, Martin Gasser, Anna-Maria Waaga-Gasser, Michael Flentje, Bülent Polat

Management of malignant pleural mesothelioma: a French multicenter retrospective study (GFPC 0802 study)

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C. Raynaud, L. Greillier, J. Mazieres, I. Monnet, B. Mastroianni, G. Robinet, G. Fraboulet, A. Dixmier, H. Berard, R. Lamy, J. Letreut, H. Lena, G. Oliviero, S. Botta, A. Vergnenegre, I. Borget, C. Chouaid

A qualitative study of women’s views on overdiagnosis and screening for thyroid cancer in Korea

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Sang Hee Park, Bomyee Lee, Sangeun Lee, Eunji Choi, Eun-Bi Choi, Jisu Yoo, Jae Kwan Jun, Kui Son Choi

Prognostic significance of classified extramural tumor deposits and extracapsular lymph node invasion in T3–4 colorectal cancer: a retrospective single-center study

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Tomoki Yamano, Shuho Semba, Masafumi Noda, Mie Yoshimura, Masayoshi Kobayashi, Michiko Hamanaka, Naohito Beppu, Aya Yano, Kiyoshi Tsukamoto, Nagahide Matsubara, Naohiro Tomita

Development of a fluorescence–based multiplex genotyping method for simultaneous determination of human papillomavirus infections and viral loads

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Zhengrong Sun, Rong Zhang, Zhonghua Liu, Chao Liu, Xiulin Li, Weiqiang Zhou, Lianxia Yang, Qiang Ruan, Xu Zhang

MicroRNA-363 targets myosin 1B to reduce cellular migration in head and neck cancer

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Bhavana V. Chapman, Abigail I. Wald, Parvez Akhtar, Ana C. Munko, Jingjing Xu, Sandra P. Gibson, Jennifer R. Grandis, Robert L. Ferris, Saleem A. Khan

Argonaute 2 and nasopharyngeal carcinoma: a genetic association study and functional analysis

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Peiyao Li, Jinfeng Meng, Yun Zhai, Hongxing Zhang, Lixia Yu, Zhifu Wang, Xiaoai Zhang, Pengbo Cao, Xi Chen, Yuqing Han, Yang Zhang, Huipeng Chen, Yan Ling, Yuxia Li, Ying Cui, Jin-Xin Bei, Yi-Xin Zeng, Fuchu He, Gangqiao Zhou

Pituitary metastasis of hepatocellular carcinoma presenting with panhypopituitarism: a case report

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• Case report

Tomoko Tanaka, Katsushi Hiramatsu, Takuto Nosaka, Yasushi Saito, Tatsushi Naito, Kazuto Takahashi, Kazuya Ofuji, Hidetaka Matsuda, Masahiro Ohtani, Tomoyuki Nemoto, Hiroyuki Suto, Tatsuya Yamamoto, Hirohiko Kimura, Yasunari Nakamoto

Primary myeloma interaction and growth in coculture with healthy donor hematopoietic bone marrow

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Rakesh Bam, Sharmin Khan, Wen Ling, Shelton S. Randal, Xin Li, Bart Barlogie, Ricky Edmondson, Shmuel Yaccoby

Relationship between body mass index and the expression of hormone receptors or human epidermal growth factor receptor 2 with respect to breast cancer survival

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Ye Won Jeon, Su Hwan Kang, Min Ho Park, Woosung Lim, Se Heun Cho, Young Jin Suh

Curcumin analog WZ35 induced cell death via ROS-dependent ER stress and G2/M cell cycle arrest in human prostate cancer cells

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Xiuhua Zhang, Minxiao Chen, Peng Zou, Karvannan Kanchana, Qiaoyou Weng, Wenbo Chen, Peng Zhong, Jiansong Ji, Huiping Zhou, Langchong He, Guang Liang

Ascorbic acid and ascorbate-2-phosphate decrease HIF activity and malignant properties of human melanoma cells

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Sarah L. Miles, Adam P. Fischer, Sandeep J. Joshi, Richard M. Niles

Helical intensity-modulated radiotherapy of the pelvic lymph nodes with a simultaneous integrated boost to the prostate - first results of the PLATIN 1 trial

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Gregor Habl, Sonja Katayama, Matthias Uhl, Kerstin A. Kessel, Lutz Edler, Juergen Debus, Klaus Herfarth, Florian Sterzing

Enhancing SHP-1 expression with 5-azacytidine may inhibit STAT3 activation and confer sensitivity in lestaurtinib (CEP-701)-resistant FLT3-ITD positive acute myeloid leukemia

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Hamid Ali Nagi Al-Jamal, Siti Asmaa Mat Jusoh, Rosline Hassan, Muhammad Farid Johan

Chemopreventive effect of chalcone derivative, L2H17, in colon cancer development

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Shanmei Xu, Minxiao Chen, Wenbo Chen, Junguo Hui, Jiansong Ji, Shuping Hu, Jianmin Zhou, Yi Wang, Guang Liang

Determining the origin of synchronous multifocal bladder cancer by exome sequencing

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Ömer Acar, Ezgi Özkurt, Gulfem Demir, Hilal Saraç, Can Alkan, Tarık Esen, Mehmet Somel, Nathan A. Lack

Androgen receptor status is highly conserved during tumor progression of breast cancer

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André Grogg, Mafalda Trippel, Katrin Pfaltz, Claudia Lädrach, Raoul A. Droeser, Nikola Cihoric, Bodour Salhia, Martin Zweifel, Coya Tapia

Inhibiting inducible miR-223 further reduces viable cells in human cancer cell lines MCF-7 and PC3 treated by celastrol

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Lu Cao, Xue Zhang, Fanfan Cao, Ying Wang, Yufan Shen, Chunxin Yang, Georges Uzan, Bin Peng, Denghai Zhang

Molecular and pathological characterization of the EZH2 rs3757441 single nucleotide polymorphism in colorectal cancer

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Lorenzo Fornaro, Pinuccia Faviana, Veronica De Gregorio, Caterina Vivaldi, Elisa Paolicchi, Gianluca Masi, Fotios Loupakis, Elisa Sensi, Cristiana Lupi, Gabriella Fontanini, Yuzhuo Wang, Romano Danesi, Alfredo Falcone, Francesco Crea

G-8 indicates overall and quality-adjusted survival in older head and neck cancer patients treated with curative radiochemotherapy

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Lies Pottel, Michelle Lycke, Tom Boterberg, Hans Pottel, Laurence Goethals, Fréderic Duprez, Sylvie Rottey, Yolande Lievens, Nele Van Den Noortgate, Kurt Geldhof, Véronique Buyse, Khalil Kargar-Samani, Véronique Ghekiere, Philip R. Debruyne

Lung cancer mortality and years of potential life lost among males and females over six decades in a country with high smoking prevalence: an observational study

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Ulrich John, Monika Hanke

Genomic profiling of CHEK2*1100delC-mutated breast carcinomas

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Maarten P. G. Massink, Irsan E. Kooi, John W. M. Martens, Quinten Waisfisz, Hanne Meijers-Heijboer

Awareness of preventive medication among women at high risk for breast cancer and their willingness to consider transdermal or oral tamoxifen: a focus group study

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Lindsey C. Karavites, Subhashini Allu, Seema A. Khan, Karen Kaiser

High efficacy of the MACOP-B regimen in the treatment of adult Langerhans cell histiocytosis, a 20 year experience

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Enrico Derenzini, Vittorio Stefoni, Cinzia Pellegrini, Letizia Gandolfi, Alessandro Broccoli, Beatrice Casadei, Federica Quirini, Lisa Argnani, Lorenzo Tonialini, Pier Luigi Zinzani

Prognostic significance of ST3GAL-1 expression in patients with clear cell renal cell carcinoma

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Qi Bai, Li Liu, Yu Xia, Qilai Long, Jiajun Wang, Jiejie Xu, Jianming Guo

Alcohol consumption, body mass index and breast cancer risk by hormone receptor status: Women’ Lifestyle and Health Study

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Aesun Shin, Sven Sandin, Marie Lof, Karen L. Margolis, Kyeezu Kim, Elisabeth Couto, Hans Olov Adami, Elisabete Weiderpass

Chemotherapeutic agents attenuate CXCL12-mediated migration of colon cancer cells by selecting for CXCR4-negative cells and increasing peptidase CD26

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Murray J. Cutler, Erica L. Lowthers, Cynthia L. Richard, Dagmar M. Hajducek, Paul A. Spagnuolo, Jonathan Blay

Network analysis of an in vitro model of androgen-resistance in prostate cancer

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Sujitra Detchokul, Aparna Elangovan, Edmund J. Crampin, Melissa J. Davis, Albert G. Frauman

From palliative to curative treatment - stage IV mucinous adenocarcinoma, successfully treated with metronomic capecitabine in combination with Bevacizumab and surgery- a case report

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• Case report