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BMC Cancer

Ausgabe 1/2015

Inhalt (1026 Artikel)

Open Access Research article

Liposome encapsulated zoledronate favours M1-like behaviour in murine macrophages cultured with soluble factors from breast cancer cells

Sofia Sousa, Seppo Auriola, Jukka Mönkkönen, Jorma Määttä

Open Access Research article

Clinicopathological significance of nuclear factor (erythroid-2)-related factor 2 (Nrf2) expression in gastric cancer

Yota Kawasaki, Sumiya Ishigami, Takaaki Arigami, Yoshikazu Uenosono, Shigehiro Yanagita, Yasuto Uchikado, Yoshiaki Kita, Yuka Nishizono, Hiroshi Okumura, Akihiro Nakajo, Yuko Kijima, Kosei Maemura, Shoji Natsugoe

Open Access Research article

Expression and clinical significance of c-Met in advanced esophageal squamous cell carcinoma

Yingying Xu, Zhi Peng, Zhongwu Li, Ming Lu, Jing Gao, Yilin Li, Yanyan Li, Lin Shen

Open Access DEBATE

Computational cancer biology: education is a natural key to many locks

Frank Emmert-Streib, Shu-Dong Zhang, Peter Hamilton

Open Access Case report

Molecular characteristics of endometrial cancer coexisting with peritoneal malignant mesothelioma in Li-Fraumeni-like syndrome

Angel Chao, Chyong-Huey Lai, Yun-Shien Lee, Shir-Hwa Ueng, Chiao-Yun Lin, Tzu-Hao Wang

Open Access Research article

Androgen-regulation of the protein tyrosine phosphatase PTPRR activates ERK1/2 signalling in prostate cancer cells

Jennifer Munkley, Nicholas P Lafferty, Gabriela Kalna, Craig N Robson, Hing Y Leung, Prabhakar Rajan, David J Elliott

Open Access Research article

Role of baseline echocardiography prior to initiation of anthracycline-based chemotherapy in breast cancer patients

Alain Mina, Hind Rafei, Maya Khalil, Yasmine Hassoun, Zeina Nasser, Arafat Tfayli

Open Access Technical advance

Microfluidic model of ductal carcinoma in situ with 3D, organotypic structure

Lauren L Bischel, David J Beebe, Kyung E Sung

Open Access Research article

STK33 overexpression in hypopharyngeal squamous cell carcinoma: possible role in tumorigenesis

Lingyan Huang, Chen Chen, Guodong Zhang, Yuanrong Ju, Jianzhong Zhang, Haibo Wang, Jianfeng Li

Open Access Research article

Histopathological features predict metastatic potential in locally advanced colon carcinomas

Caren Jayasinghe, Nektaria Simiantonaki, Charles James Kirkpatrick

Open Access Research article

Prognostic factors and treatment outcomes in patients with Small Bowel Adenocarcinoma (SBA): The Royal Marsden Hospital (RMH) experience

Khurum Khan, Clare Peckitt, Francesco Sclafani, David Watkins, Sheela Rao, Naureen Starling, Vikram Jain, Sachin Trivedi, Susannah Stanway, David Cunningham, Ian Chau

Open Access Case report

Ewing sarcoma of the liver with multilocular cystic mass formation: a case report

Yukinori Ozaki, Yuji Miura, Shigehiro Koganemaru, Koichi Suyama, Naoko Inoshita, Takeshi Fujii, Masaji Hashimoto, Tetsuo Tamura, Kazuo Takeuchi, Toshimi Takano

Open Access Research article

Nitric oxide donors increase PVR/CD155 DNAM-1 ligand expression in multiple myeloma cells: role of DNA damage response activation

Cinzia Fionda, Maria Pia Abruzzese, Alessandra Zingoni, Alessandra Soriani, Biancamaria Ricci, Rosa Molfetta, Rossella Paolini, Angela Santoni, Marco Cippitelli

Open Access Research article

Downregulation of EphA5 by promoter methylation in human prostate cancer

Shibao Li, Yingfeng Zhu, Chunguang Ma, Zhenhua Qiu, Xinju Zhang, Zhihua Kang, Zhiyuan Wu, Hua Wang, Xiao Xu, Hu Zhang, Guoqiang Ren, Jianmin Tang, Xiangyu Li, Ming Guan

Open Access Research article

The novel histone deacetylase inhibitor, N-hydroxy-7-(2-naphthylthio) hepatonomide, exhibits potent antitumor activity due to cytochrome-c-release-mediated apoptosis in renal cell carcinoma cells

Ki Cheong Park, Jun Hyeok Heo, Jeong Yong Jeon, Hye Ji Choi, A Ra Jo, Seung Won Kim, Ho Jeong Kwon, Sung Joon Hong, Kyung Seok Han

Open Access Research article

Methylation and expression of the tumour suppressor, PRDM5, in colorectal cancer and polyp subgroups

Catherine E Bond, Mark L Bettington, Sally-Ann Pearson, Diane M McKeone, Barbara A Leggett, Vicki LJ Whitehall

Open Access Research article

Antihormonal agents as a strategy to improve the effect of chemo-radiation in cervical cancer: in vitro and in vivo study

Mariana Segovia-Mendoza, Rafael Jurado, Roser Mir, Luis A Medina, Heriberto Prado-Garcia, Patricia Garcia-Lopez

Open Access Research article

TOX3 is expressed in mammary ER+ epithelial cells and regulates ER target genes in luminal breast cancer

Akop Seksenyan, Asha Kadavallore, Ann E Walts, Brian de la Torre, Dror Berel, Samuel P Strom, Parinaz Aliahmad, Vincent A Funari, Jonathan Kaye

Open Access Case report

Bilateral Diffuse Uveal Melanocytic Proliferation (BDUMP) associated with B-cell lymphoma: report of a rare case

Maria Pefkianaki, Rupesh Agrawal, Parul Desai, Carlos Pavesio, Mandeep S Sagoo

Open Access Research article

Cell fusion between gastric epithelial cells and mesenchymal stem cells results in epithelial-to-mesenchymal transition and malignant transformation

Xianghui He, Baosong Li, Yang Shao, Na Zhao, Yiling Hsu, Zhixiang Zhang, Liwei Zhu

Open Access Research article

Caveolin-1 accumulation in the tongue cancer tumor microenvironment is significantly associated with poor prognosis: an in-vivo and in-vitro study

Marilena Vered, Meri Lehtonen, Lari Hotakainen, Emma Pirilä, Susanna Teppo, Pia Nyberg, Raija Sormunen, Ayelet Zlotogorski-Hurvitz, Tuula Salo, Dan Dayan

Open Access Research article

Development of a semi-conductor sequencing-based panel for genotyping of colon and lung cancer by the Onconetwork consortium

Bastiaan BJ Tops, Nicola Normanno, Henriette Kurth, Eliana Amato, Andrea Mafficini, Nora Rieber, Delphine Le Corre, Anna Maria Rachiglio, Anne Reiman, Orla Sheils, Christoph Noppen, Ludovic Lacroix, Ian A Cree, Aldo Scarpa, Marjolijn JL Ligtenberg, Pierre Laurent-Puig

Open Access Research article

Prognostic survival model for people diagnosed with invasive cutaneous melanoma

Peter D Baade, Patrick Royston, Philipa H Youl, Martin A Weinstock, Alan Geller, Joanne F Aitken

Open Access Research article

Weight and weight change following breast cancer: evidence from a prospective, population-based, breast cancer cohort study

Dimitrios Vagenas, Tracey DiSipio, Diana Battistutta, Wendy Demark-Wahnefried, Sheree Rye, John Bashford, Chris Pyke, Christobel Saunders, Sandra C Hayes

Open Access Research article

MiR-130b plays an oncogenic role by repressing PTEN expression in esophageal squamous cell carcinoma cells

Tingting Yu, Risheng Cao, Shuo Li, Mingen Fu, Lihua Ren, Weixu Chen, Hong Zhu, Qiang Zhan, Ruihua Shi

Open Access Research article

Association of PALB2 sequence variants with the risk of familial and early-onset breast cancer in a South-American population

Yessica Leyton, Patricio Gonzalez-Hormazabal, Rafael Blanco, Teresa Bravo, Ricardo Fernandez-Ramires, Sebastian Morales, Natalia Landeros, Jose M Reyes, Octavio Peralta, Julio C Tapia, Fernando Gomez, Enrique Waugh, Gladys Ibañez, Janara Pakomio, Gilberto Grau, Lilian Jara

Open Access Research article

MET FISH-positive status predicts short progression-free survival and overall survival after gefitinib treatment in lung adenocarcinoma with EGFR mutation

Rintaro Noro, Masahiro Seike, Fenfei Zou, Chie Soeno, Kuniko Matsuda, Teppei Sugano, Nobuhiko Nishijima, Masaru Matsumoto, Kazuhiro Kitamura, Seiji Kosaihira, Yuji Minegishi, Akinobu Yoshimura, Kaoru Kubota, Akihiko Gemma

Open Access Research article

Retrospective review using targeted deep sequencing reveals mutational differences between gastroesophageal junction and gastric carcinomas

Hector H Li-Chang, Katayoon Kasaian, Ying Ng, Amy Lum, Esther Kong, Howard Lim, Steven JM Jones, David G Huntsman, David F Schaeffer, Stephen Yip

Open Access Research article

Serum HE4 detects recurrent endometrial cancer in patients undergoing routine clinical surveillance

Donal J Brennan, Andreas Hackethal, Kristy P Mann, Irene Mutz-Dehbalaie, Heidi Fiegl, Christian Marth, Andreas Obermair

Open Access Research article

Melatonin attenuates the TLR4-mediated inflammatory response through MyD88- and TRIF-dependent signaling pathways in an in vivo model of ovarian cancer

Luiz Gustavo A Chuffa, Beatriz A Fioruci-Fontanelli, Leonardo O Mendes, Fábio R Ferreira Seiva, Marcelo Martinez, Wagner J Fávaro, Raquel F Domeniconi, Patrícia FF Pinheiro, Lucilene Delazari dos Santos, Francisco Eduardo Martinez

Open Access Research article

High-density SNP arrays improve detection of HER2 amplification and polyploidy in breast tumors

Thomas v O Hansen, Jonas Vikesaa, Sine S Buhl, Henrik H Rossing, Vera Timmermans-Wielenga, Finn C Nielsen

Open Access Research article

Concurrent paclitaxel-based chemo-radiotherapy for post-surgical microscopic residual tumor at the bronchial margin (R1 resection) in non-small-cell lung cancer

Meixiang Zhou, Tao Li, Yongmei Liu, Changjin Sun, Na Li, Yong Xu, Jiang Zhu, Zhenyu Ding, Yongsheng Wang, Meijuan Huang, Feng Peng, Jin Wang, Li Ren, You Lu, Youling Gong

Open Access Research article

High levels of dietary soy decrease mammary tumor latency and increase incidence in MTB-IGFIR transgenic mice

Katrina L Watson, Leanne Stalker, Robert A Jones, Roger A Moorehead

Open Access Research article

Cholangiocarcinoma: spectrum of appearances on Gd-EOB-DTPA-enhanced MR imaging and the effect of biliary function on signal intensity

Shi-Ting Feng, Ling Wu, Huasong Cai, Tao Chan, Yanji Luo, Zhi Dong, Keguo Zheng, Zi-Ping Li

Open Access Research article

Trogocytosis-mediated expression of HER2 on immune cells may be associated with a pathological complete response to trastuzumab-based primary systemic therapy in HER2-overexpressing breast cancer patients

Eiji Suzuki, Tatsuki R Kataoka, Masahiro Hirata, Kosuke Kawaguchi, Mariko Nishie, Hironori Haga, Masakazu Toi

Open Access Study protocol

Supervised physical exercise to improve the quality of life of cancer patients: the EFICANCER randomised controlled trial

Aintzane Sancho, Sergio Carrera, Marisol Arietaleanizbeascoa, Veronica Arce, Nere Mendizabal Gallastegui, Anna Giné March, Aitor Sanz-Guinea, Araceli Eskisabel, Ana Lopez Rodriguez, Rosa A Martín, Guillermo Lopez-Vivanco, Gonzalo Grandes

Open Access Research article

Rosiglitazone may reduce non-melanoma skin cancer risk in Taiwanese

Chin-Hsiao Tseng

Open Access Research article

Fluoroquinolone resistance in bacteremic and low risk febrile neutropenic patients with cancer

Sheng Zhang, Qing Wang, Yun Ling, Xichun Hu

Open Access Research article

Number of negative lymph nodes is associated with disease-free survival in patients with breast cancer

San-Gang Wu, Jia-Yuan Sun, Juan Zhou, Feng-Yan Li, Qin Lin, Huan-Xin Lin, Xun-Xing Guan, Zhen-Yu He

Open Access Research article

S100A4-neutralizing antibody suppresses spontaneous tumor progression, pre-metastatic niche formation and alters T-cell polarization balance

Birgitte Grum-Schwensen, Jörg Klingelhöfer, Mette Beck, Charlotte Menné Bonefeld, Petra Hamerlik, Per Guldberg, Mariam Grigorian, Eugene Lukanidin, Noona Ambartsumian

Open Access Research article

Clonal distribution of BCR-ABL1 mutations and splice isoforms by single-molecule long-read RNA sequencing

Lucia Cavelier, Adam Ameur, Susana Häggqvist, Ida Höijer, Nicola Cahill, Ulla Olsson-Strömberg, Monica Hermanson

Open Access Research article

Clinical outcome of patients with pancreatic metastases from renal cell cancer

Takeshi Yuasa, Naoko Inoshita, Akio Saiura, Shinya Yamamoto, Shinji Urakami, Hitoshi Masuda, Yasuhisa Fujii, Iwao Fukui, Yuichi Ishikawa, Junji Yonese

Open Access Study protocol

GRECCAR 8: impact on survival of the primary tumor resection in rectal cancer with unresectable synchronous metastasis: a randomized multicentre study

Eddy Cotte, Laurent Villeneuve, Guillaume Passot, Gilles Boschetti, Sylvie Bin-Dorel, Yves Francois, Olivier Glehen

Open Access Study protocol

NEOSCOPE: a randomised Phase II study of induction chemotherapy followed by either oxaliplatin/capecitabine or paclitaxel/carboplatin based chemoradiation as pre-operative regimen for resectable oesophageal adenocarcinoma

Somnath Mukherjee, Christopher N Hurt, Sarah Gwynne, Andrew Bateman, Simon Gollins, Ganesh Radhakrishna, Maria Hawkins, Jo Canham, Wyn Lewis, Heike I Grabsch, Ricky A Sharma, Wendy Wade, Rhydian Maggs, Bethan Tranter, Ashley Roberts, David Sebag-Montefiore, Timothy Maughan, Gareth Griffiths, Tom Crosby

Open Access Research article

Occupational exposure and sinonasal cancer: a systematic review and meta-analysis

Alessandra Binazzi, Pierpaolo Ferrante, Alessandro Marinaccio

Open Access Research article

YY1 suppresses FEN1 over-expression and drug resistance in breast cancer

Jianwei Wang, Lina Zhou, Zhi Li, Ting Zhang, Wenpeng Liu, Zheng Liu, Yate-Ching Yuan, Fan Su, Lu Xu, Yan Wang, Xiaotong Zhou, Hong Xu, Yuejin Hua, Ying-Jie Wang, Li Zheng, Yue-E Teng, Binghui Shen

Open Access Research article

Impact of diabetes type II and chronic inflammation on pancreatic cancer

Dietmar Zechner, Tobias Radecke, Jonas Amme, Florian Bürtin, Ann-Christin Albert, Lars Ivo Partecke, Brigitte Vollmar

Open Access Study protocol

Single arm NCRI phase II study of CHOP in combination with Ofatumumab in induction and maintenance for patients with newly diagnosed Richter’s syndrome

Toby A Eyre, Ruth Clifford, Corran Roberts, Lucy Boyle, Anne Francis, Anna Schuh, Susan J Dutton

Open Access Research article

Co-expression of S100A14 and S100A16 correlates with a poor prognosis in human breast cancer and promotes cancer cell invasion

Mizuko Tanaka, Naoki Ichikawa-Tomikawa, Namiko Shishito, Keisuke Nishiura, Tomiko Miura, Ayumi Hozumi, Hideki Chiba, Sayaka Yoshida, Tohru Ohtake, Takashi Sugino

Open Access Research article

Gamma knife radiosurgery for elderly patients with brain metastases: evaluation of scoring systems that predict survival

Jae-Young Park, Kyung-Sub Moon, Kyung-Hwa Lee, Sa-Hoe Lim, Woo-Youl Jang, Hyeseon Lee, Tae-Young Jung, In-Young Kim, Shin Jung

Open Access Research article

The differential anti-tumour effects of zoledronic acid in breast cancer – evidence for a role of the activin signaling pathway

Caroline Wilson, Penelope Ottewell, Robert E Coleman, Ingunn Holen

Open Access Research article

Plasma clusterin as a candidate pre-diagnosis marker of colorectal cancer risk in the Florence cohort of the European Prospective Investigation into Cancer and Nutrition: a pilot study

Michela Bertuzzi, Cristina Marelli, Renzo Bagnati, Alessandro Colombi, Roberto Fanelli, Calogero Saieva, Marco Ceroti, Benedetta Bendinelli, Saverio Caini, Luisa Airoldi, Domenico Palli

Open Access Research article

Impact of age and gender on tumor related prognosis in gastrointestinal stromal tumors (GIST)

Klaus Kramer, Uwe Knippschild, Benjamin Mayer, Kira Bögelspacher, Hanno Spatz, Doris Henne-Bruns, Abbas Agaimy, Matthias Schwab, Michael Schmieder

Open Access Case report

Melan-A/MART-1 immunity in a EWS-ATF1 translocated clear cell sarcoma patient treated with sunitinib: a case report

Marcella Tazzari, Elena Palassini, Barbara Vergani, Antonello Villa, Francesca Rini, Tiziana Negri, Chiara Colombo, Flavio Crippa, Carlo Morosi, Paolo G Casali, Silvana Pilotti, Silvia Stacchiotti, Licia Rivoltini, Chiara Castelli

Open Access Research article

Phase II study of preoperative bevacizumab, capecitabine and radiotherapy for resectable locally-advanced rectal cancer

Margarita García, Mercedes Martinez-Villacampa, Cristina Santos, Valentin Navarro, Alex Teule, Ferran Losa, Aleydis Pisa, Maria Cambray, Gemma Soler, Laura Lema, Esther Kreisler, Agnes Figueras, Xavier San Juan, Francesc Viñals, Sebastiano Biondo, Ramon Salazar

Open Access Research article

A randomized phase II study of capecitabine-based chemoradiation with or without bevacizumab in resectable locally advanced rectal cancer: clinical and biological features

Ramon Salazar, Jaume Capdevila, Berta Laquente, Jose Luis Manzano, Carles Pericay, Mercedes Martínez Villacampa, Carlos López, Ferran Losa, Maria Jose Safont, Auxiliadora Gómez, Vicente Alonso, Pilar Escudero, Javier Gallego, Javier Sastre, Cristina Grávalos, Sebastiano Biondo, Amalia Palacios, Enrique Aranda

Open Access Research article

Next generation sequencing of exceptional responders with BRAF-mutant melanoma: implications for sensitivity and resistance

Jennifer Wheler, Roman Yelensky, Gerald Falchook, Kevin B Kim, Patrick Hwu, Apostolia M Tsimberidou, Philip J Stephens, David Hong, Maureen T Cronin, Razelle Kurzrock

Open Access Research article

Adjuvant chemotherapy for stage III colon cancer: relative dose intensity and survival among veterans

Sherrie L Aspinall, Chester B Good, Xinhua Zhao, Francesca E Cunningham, Bernadette B Heron, Mark Geraci, Vida Passero, Roslyn A Stone, Kenneth J Smith, Renee Rogers, Jenna Shields, Megan Sartore, D Patrick Boyle, Sherry Giberti, John Szymanski, Doug Smith, Allen Ha, Jolynn Sessions, Shawn Depcinski, Shane Fishco, Irvin Molina, Tanja Lepir, Carmela Jean, Lymaris Cruz-Diaz, Jessica Motta, Rebeca Calderon-Vargas, Janelle Maland, Sean Keefe, Marshall Tague, Alice Leone, Brian Glovack, Blair Kaplan, Sean Cosgriff, Lindsay Kaster, Ivy Tonnu-Mihara, Kimmai Nguyen, Jenna Carmichael, Linda Clifford, Kan Lu, Gurkamal Chatta

Open Access Study protocol

Return to work in sick-listed cancer survivors with job loss: design of a randomised controlled trial

Martine P van Egmond, Saskia FA Duijts, Sylvia J Vermeulen, Allard J van der Beek, Johannes R Anema

Open Access Research article

Identification of a novel microRNA signature associated with intrahepatic cholangiocarcinoma (ICC) patient prognosis

Mei-Yin Zhang, Shu-Hong Li, Guo-Liang Huang, Guo-He Lin, Ze-Yu Shuang, Xiang-Ming Lao, Li Xu, Xiao-Jun Lin, Hui-Yun Wang, Sheng-Ping Li

Open Access Research article

Significant correlation between urinary N1, N12-diacetylspermine and tumor invasiveness in patients with clinical stage IA non-small cell lung cancer

Yusuke Takahashi, Hirotoshi Horio, Koji Sakaguchi, Kyoko Hiramatsu, Masao Kawakita

Open Access Research article

Increased expression of colony stimulating factor-1 is a predictor of poor prognosis in patients with clear-cell renal cell carcinoma

Liu Yang, Qian Wu, Le Xu, Weijuan Zhang, Yu Zhu, Haiou Liu, Jiejie Xu, Jianxin Gu

Open Access Research article

Multiple myeloma cells alter the senescence phenotype of bone marrow mesenchymal stromal cells under participation of the DLK1-DIO3 genomic region

Rimma Berenstein, Olga Blau, Axel Nogai, Marlies Waechter, Ekaterina Slonova, Martin Schmidt-Hieber, Annegret Kunitz, Antonio Pezzutto, Bernd Doerken, Igor Wolfgang Blau

Open Access Research article

Circadian variation in plasma 5-fluorouracil concentrations during a 24 hour constant-rate infusion

Gini F Fleming, Philip Schumm, Greg Friberg, Mark J Ratain, Uchenna O Njiaju, Richard L Schilsky

Open Access Research article

Dermcidin exerts its oncogenic effects in breast cancer via modulation of ERBB signaling

Jasna Bancovik, Dayson F Moreira, Daniel Carrasco, Jun Yao, Dale Porter, Ricardo Moura, Anamaria Camargo, Cibely C Fontes-Oliveira, Miguel G Malpartida, Silvia Carambula, Edouard Vannier, Bryan E Strauss, Alda Wakamatsu, Venancio AF Alves, Angela F Logullo, Fernando A Soares, Kornelia Polyak, José E Belizário

Open Access Research article

Targeting cMET with INC280 impairs tumour growth and improves efficacy of gemcitabine in a pancreatic cancer model

Franziska Brandes, Katharina Schmidt, Christine Wagner, Julia Redekopf, Hans Jürgen Schlitt, Edward Kenneth Geissler, Sven Arke Lang

Open Access Research article

Sex differences in cancer survival in Estonia: a population-based study

Kaire Innos, Peeter Padrik, Vahur Valvere, Tiiu Aareleid

Open Access Research article

Incidence, time course and independent risk factors for metachronous peritoneal carcinomatosis of gastric origin – a longitudinal experience from a prospectively collected database of 1108 patients

Florian Seyfried, Burkhard H von Rahden, Alexander D Miras, Martin Gasser, Uwe Maeder, Volker Kunzmann, Christoph-Thomas Germer, Jörg OW Pelz, Alexander G Kerscher

Open Access Research article

Lung neuroendocrine tumors: correlation of ubiquitinylation and sumoylation with nucleo-cytosolic partitioning of PTEN

Stéphane Collaud, Verena Tischler, Andrej Atanassoff, Thomas Wiedl, Paul Komminoth, Christian Oehlschlegel, Walter Weder, Alex Soltermann

Open Access Research article

Metaplastic breast cancer: a comparison between the most common histologies with poor immunohistochemistry factors

Salim Abraham Barquet-Muñoz, Silvia Patricia Villarreal-Colin, Luis Alonso Herrera-Montalvo, Ernesto Soto-Reyes, Carlos Pérez-Plasencia, Jaime Coronel-Martínez, Delia Pérez-Montiel, Rafael Vázquez-Romo, David Cantú de León

Open Access Research article

Enhanced tumour cell nuclear targeting in a tumour progression model

Michael S Nastasie, Helmut Thissen, David A Jans, Kylie M Wagstaff

Open Access Research article

Effects of supervised exercise on cancer-related fatigue in breast cancer survivors: a systematic review and meta-analysis

José Francisco Meneses-Echávez, Emilio González-Jiménez, Robinson Ramírez-Vélez

Open Access Research article

Local control in metastatic neuroblastoma in children over 1 year of age

Maria Antonietta De Ioris, Alessandro Crocoli, Benedetta Contoli, Maria Carmen Garganese, Gianluigi Natali, Paolo Tomà, Alessandro Jenkner, Renata Boldrini, Maria Debora De Pasquale, Giuseppe Maria Milano, Silvia Madafferi, Aurora Castellano, Franco Locatelli, Alessandro Inserra

Open Access Research article

Gastric cancer-associated enhancement of von Willebrand factor is regulated by vascular endothelial growth factor and related to disease severity

Xia Yang, Hai-jian Sun, Zhi-rong Li, Hao Zhang, Wei-jun Yang, Bing Ni, Yu-zhang Wu

Open Access Technical advance

Screening of exon 11 of BRCA1 gene using the high resolution melting approach for diagnosis in Moroccan breast cancer patients

Meryam El Khachibi, Brehima Diakite, Khalil Hamzi, Abdallah Badou, Mohamed Amine Senhaji, Amina Bakhchane, Hassan Jouhadi, Abdelhamid Barakat, Abdellatif Benider, Sellama Nadifi

Open Access Research article

The role of HGF/MET and FGF/FGFR in fibroblast-derived growth stimulation and lapatinib-resistance of esophageal squamous cell carcinoma

Shin Saito, Kazue Morishima, Takashi Ui, Hiroko Hoshino, Daisuke Matsubara, Shumpei Ishikawa, Hiroyuki Aburatani, Masashi Fukayama, Yoshinori Hosoya, Naohiro Sata, Alan K Lefor, Yoshikazu Yasuda, Toshiro Niki

Open Access Research article

The prognostic significance of age in operated and non-operated colorectal cancer

Jing Li, Zhu Wang, Xin Yuan, Lichun Xu, Jiandong Tong

Open Access Research article

Human non-small cell lung cancer expresses putative cancer stem cell markers and exhibits the transcriptomic profile of multipotent cells

Norashikin Zakaria, Narazah Mohd Yusoff, Zubaidah Zakaria, Moon Nian Lim, Puteri J Noor Baharuddin, Kamal Shaik Fakiruddin, Badrul Yahaya

Open Access Research article

Tumor evolution and intratumor heterogeneity of an epithelial ovarian cancer investigated using next-generation sequencing

Jung-Yun Lee, Jung-Ki Yoon, Boyun Kim, Soochi Kim, Min A Kim, Hyeonseob Lim, Duhee Bang, Yong-Sang Song

Open Access Research article

HNRNP G and HTRA2-BETA1 regulate estrogen receptor alpha expression with potential impact on endometrial cancer

Marc Hirschfeld, Yi Qin Ouyang, Markus Jaeger, Thalia Erbes, Marzenna Orlowska-Volk, Axel zur Hausen, Elmar Stickeler

Open Access Case report

Ipilimumab and immune-mediated adverse events: a case report of anti-CTLA4 induced ileitis

Olga Venditti, Delia De Lisi, Marco Caricato, Damiano Caputo, Gabriella Teresa Capolupo, Chiara Taffon, Elisa Pagliara, Sofia Battisi, Anna Maria Frezza, Andrea Onetti Muda, Giuseppe Tonini, Daniele Santini

Open Access Research article

Radiosensitization with combined use of olaparib and PI-103 in triple-negative breast cancer

Na Young Jang, Dan Hyo Kim, Bong Jun Cho, Eun Jung Choi, Jong-Soo Lee, Hong-Gyun Wu, Eui Kyu Chie, In Ah Kim

Open Access Research article

Role of SMC1A overexpression as a predictor of poor prognosis in late stage colorectal cancer

Jianwei Wang, Shaojun Yu, Liming Cui, Wenhui Wang, Jun Li, Ke Wang, Xinyuan Lao

Open Access Research article

Fibulin-4 is associated with tumor progression and a poor prognosis in ovarian carcinomas

Jie Chen, Zhao Liu, Shuang Fang, Rui Fang, Xi Liu, Yueran Zhao, XiangXin Li, Lei Huang, Jie Zhang

Open Access Research article

MiRNA-141 and miRNA-200b are closely related to invasive ability and considered as decision-making biomarkers for the extent of PLND during cystectomy

Wentao Liu, Lin Qi, Hui Lv, Xiongbing Zu, Minfeng Chen, Jun Wang, Longfei Liu, Feng Zeng, Yuan Li

Open Access Research article

ADAM12-L is a direct target of the miR-29 and miR-200 families in breast cancer

Sara Duhachek-Muggy, Anna Zolkiewska

Open Access Research article

International trends in primary liver cancer incidence from 1973 to 2007

Yue Zhang, Jian-Song Ren, Ju-Fang Shi, Ni Li, Yu-Ting Wang, Chunfeng Qu, Yawei Zhang, Min Dai

Open Access Reviewer acknowledgement

BMC Cancer reviewer acknowledgement 2014

Dafne Solera

Open Access Research article

Resveratrol suppresses epithelial-to-mesenchymal transition in colorectal cancer through TGF-β1/Smads signaling pathway mediated Snail/E-cadherin expression

Qing Ji, Xuan Liu, Zhifen Han, Lihong Zhou, Hua Sui, Linlin Yan, Haili Jiang, Jianlin Ren, Jianfeng Cai, Qi Li

Open Access Study protocol

The effect of individualized NUTritional counseling on muscle mass and treatment outcome in patients with metastatic COLOrectal cancer undergoing chemotherapy: a randomized controlled trial protocol

Anne van der Werf, Susanne Blauwhoff-Buskermolen, Jacqueline AE Langius, Johannes Berkhof, Henk MW Verheul, Marian AE de van der Schueren

Open Access Research article

The association between human papillomavirus 16 and esophageal cancer in Chinese population: a meta-analysis

Shao-Kai Zhang, Lan-Wei Guo, Qiong Chen, Meng Zhang, Shu-Zheng Liu, Pei-Liang Quan, Jian-Bang Lu, Xi-Bin Sun

Open Access Research article

The DNA load of six high-risk human papillomavirus types and its association with cervical lesions

Luisa Del Río-Ospina, Sara Cecilia Soto-De León, Milena Camargo, Darwin Andrés Moreno-Pérez, Ricardo Sánchez, Antonio Pérez-Prados, Manuel Elkin Patarroyo, Manuel Alfonso Patarroyo

Open Access Research article

Tertiary lymphoid structures are associated with higher tumor grade in primary operable breast cancer patients

Stine L Figenschau, Silje Fismen, Kristin A Fenton, Christopher Fenton, Elin S Mortensen

Open Access Research article

Nuclear expression of p65 (RelA) in patients receiving post-operative radiotherapy for locally advanced squamous cell carcinoma of the head and neck

Dirk Rades, Stefan Huttenlocher, Nina D Seibold, Maximilian P Gebhard, Christoph Thorns, Katrin Hasselbacher, Barbara Wollenberg, Steven E Schild

Open Access Research article

Lymphangiogenesis in Gastric Cancer regulated through Akt/mTOR-VEGF-C/VEGF-D axis

Hongxia Chen, Runnian Guan, Yupeng Lei, Jianyong Chen, Qi Ge, Xiaoshen Zhang, Ruoxu Dou, Hongyuan Chen, Hao Liu, Xiaolong Qi, Xiaodong Zhou, Changyan Chen

Open Access Research article

Cell type- and tumor zone-specific expression of pVEGFR-1 and its ligands influence colon cancer metastasis

Caren Jayasinghe, Nektaria Simiantonaki, Charles James Kirkpatrick

Open Access Research article

Retrospective analysis of the impact of platinum dose reduction and chemotherapy delays on the outcomes of stage III ovarian cancer patients

Sigita Liutkauskiene, Rasa Janciauskiene, Kristina Jureniene, Saulius Grizas, Rasa Malonyte, Elona Juozaityte

Open Access Research article

Vitamin D and cancer mortality in elderly women

Germaine Wong, Wai Hon Lim, Joshua Lewis, Jonathan C Craig, Robin Turner, Kathy Zhu, Ee Mun Lim, Richard Prince

Open Access Research article

Astrocyte elevated gene-1(AEG-1) induces epithelial-mesenchymal transition in lung cancer through activating Wnt/β-catenin signaling

Weiling He, Shanyang He, Zuo Wang, Hongwei Shen, Wenfeng Fang, Yang Zhang, Wei Qian, Millicent Lin, Jinglun Yuan, Jinyang Wang, Wenhua Huang, Liantang Wang, Zunfu Ke

Open Access Research article

The prognostic role of preoperative serum albumin levels in glioblastoma patients

Sheng Han, Yanming Huang, Zhonghua Li, Haipei Hou, Anhua Wu

Open Access Research article

Hunk/Mak-v is a negative regulator of intestinal cell proliferation

Karen R Reed, Igor V Korobko, Natalia Ninkina, Elena V Korobko, Ben R Hopkins, James L Platt, Vladimir Buchman, Alan R Clarke

Open Access Research article

Impact of comorbidities and use of common medications on cancer and non-cancer specific survival in esophageal carcinoma

Li-Ru He, Wei Qiao, Zhong-Xing Liao, Ritsuko Komaki, Linus Ho, Wayne L Hofstetter, Steven H Lin

Open Access Research article

The effect of chemotherapeutic agents on tumor vasculature in subcutaneous and orthotopic human tumor xenografts

Andrea S Fung, Carol Lee, Man Yu, Ian F Tannock

Open Access Research article

Nuclear factor I-C regulates E-cadherin via control of KLF4 in breast cancer

Hye-Kyung Lee, Dong-Seol Lee, Joo-Cheol Park

Open Access Research article

Clinically significant association between the maximum standardized uptake value on 18F-FDG PET and expression of phosphorylated Akt and S6 kinase for prediction of the biological characteristics of renal cell cancer

Tomoya Mizuno, Takao Kamai, Hideyuki Abe, Setsu Sakamoto, Kazuhiro Kitajima, Daisaku Nishihara, Hideo Yuki, Tsunehito Kambara, Hironori Betsunoh, Masahiro Yashi, Yoshitatsu Fukabori, Yasushi Kaji, Ken-Ichiro Yoshida

Open Access Case report

Oromandibular dystonia: a serious side effect of capecitabine

Melanie JM van Pelt-Sprangers, Eric CT Geijteman, Jelmer Alsma, Ingrid A Boere, Ron HJ Mathijssen, Stephanie CE Schuit

Open Access Research article

The prognostic value of combined TGF-β1 and ELF in hepatocellular carcinoma

Fei Ji, Shun-Jun Fu, Shun-Li Shen, Long-Juan Zhang, Qing-Hua Cao, Shao-Qiang Li, Bao-Gang Peng, Li-Jian Liang, Yun-Peng Hua

Open Access Research Article

Prediction of resistance to chemotherapy in ovarian cancer: a systematic review

Katherine L Lloyd, Ian A Cree, Richard S Savage

Open Access Research article

Overexpression of Nrf2 attenuates Carmustine-induced cytotoxicity in U87MG human glioma cells

Sangeetha Sukumari-Ramesh, Niyathi Prasad, Cargill H Alleyne Jr, John R Vender, Krishnan M Dhandapani

Open Access Case report

Successful control of heavily pretreated metastatic gastric cancer with the mTOR inhibitor everolimus (RAD001) in a patient with PIK3CA mutation and pS6 overexpression

Ji Hyun Park, Min-Hee Ryu, Young Soo Park, Sook Ryun Park, Young-Soon Na, Baek-Yeol Rhoo, Yoon-Koo Kang

Open Access Research article

Can daily intake of aspirin and/or statins influence the behavior of non-muscle invasive bladder cancer? A retrospective study on a cohort of patients undergoing transurethral bladder resection

Antonio Luigi Pastore, Giovanni Palleschi, Andrea Fuschi, Luigi Silvestri, Yazan Al Salhi, Elisabetta Costantini, Alessandro Zucchi, Vincenzo Petrozza, Cosimo de Nunzio, Antonio Carbone

Open Access Research article

Association of angiogenic factors with prognosis in esophageal cancer

Lena Dreikhausen, Susanne Blank, Leila Sisic, Ulrike Heger, Wilko Weichert, Dirk Jäger, Thomas Bruckner, Natalia Giese, Lars Grenacher, Christine Falk, Katja Ott, Thomas Schmidt

Open Access Research article

Results of multicenter double-blind placebo-controlled phase II clinical trial of Panagen preparation to evaluate its leukostimulatory activity and formation of the adaptive immune response in patients with stage II-IV breast cancer

Anastasia S Proskurina, Tatiana S Gvozdeva, Ekaterina A Alyamkina, Evgenia V Dolgova, Konstantin E Orishchenko, Valeriy P Nikolin, Nelly A Popova, Sergey V Sidorov, Elena R Chernykh, Alexandr A Ostanin, Olga Y Leplina, Victoria V Dvornichenko, Dmitriy M Ponomarenko, Galina S Soldatova, Nikolay A Varaksin, Tatiana G Ryabicheva, Stanislav N Zagrebelniy, Vladimir A Rogachev, Sergey S Bogachev, Mikhail A Shurdov

Open Access Research article

Lack of significant association between serum inflammatory cytokine profiles and the presence of colorectal adenoma

Curtis J Henry, Rebecca L Sedjo, Andrii Rozhok, Jennifer Salstrom, Dennis Ahnen, Theodore R Levin, Ralph D’Agostino Jr, Steven Haffner, James DeGregori, Tim Byers

Open Access Research article

The association of alcohol consumption with mammographic density in a multiethnic urban population

Zoe Quandt, Julie D Flom, Parisa Tehranifar, Diane Reynolds, Mary Beth Terry, Jasmine A McDonald

Open Access Research article

Microsatellite instability and mutations in BRAF and KRAS are significant predictors of disseminated disease in colon cancer

Helgi Birgisson, Karolina Edlund, Ulrik Wallin, Lars Påhlman, Hanna Göransson Kultima, Markus Mayrhofer, Patrick Micke, Anders Isaksson, Johan Botling, Bengt Glimelius, Magnus Sundström

Open Access Research Article

Patterns of chromosomal copy-number alterations in intrahepatic cholangiocarcinoma

Cyril Dalmasso, Wassila Carpentier, Catherine Guettier, Sophie Camilleri-Broët, Wyllians Vendramini Borelli, Cedália Rosane Campos dos Santos, Denis Castaing, Jean-Charles Duclos-Vallée, Philippe Broët

Open Access Study protocol

Study protocol of REGOSARC trial: activity and safety of regorafenib in advanced soft tissue sarcoma: a multinational, randomized, placebo-controlled, phase II trial

Thomas Brodowicz, Bernadette Liegl-Atzwager, Emmanuelle Tresch, Sophie Taieb, Andrew Kramar, Viktor Gruenwald, Marie Vanseymortier, Stéphanie Clisant, Jean-Yves Blay, Axel Le Cesne, Nicolas Penel

Open Access Research article

The significance of the co-existence of osteopontin and tumor-associated macrophages in gastric cancer progression

Chang-Ni Lin, Chih-Jung Wang, Ying-Jui Chao, Ming-Derg Lai, Yan-Shen Shan

Open Access Research article

Surface antigen expression on peripheral blood monocytes in women with gynecologic malignancies

Maciej Jóźwik, Osazee E Okungbowa, Alina Lipska, Marcin Jóźwik, Marzena Smoktunowicz, Andrzej Semczuk, Michał Jóźwik, Piotr Radziwon

Open Access Research article

A functional in vitro model of heterotypic interactions reveals a role for interferon-positive carcinoma associated fibroblasts in breast cancer

Abdel Nasser Hosein, Julie Livingstone, Marguerite Buchanan, James F Reid, Michael Hallett, Mark Basik

Open Access Research article

eIF6 over-expression increases the motility and invasiveness of cancer cells by modulating the expression of a critical subset of membrane-bound proteins

Michela Pinzaglia, Claudia Montaldo, Dorina Polinari, Mattei Simone, Anna La Teana, Marco Tripodi, Carmine Mancone, Paola Londei, Dario Benelli

Open Access Research article

COP1, the negative regulator of ETV1, influences prognosis in triple-negative breast cancer

Mao Ouyang, Hua Wang, Jieyi Ma, Weiming Lü, Jie Li, Chen Yao, Guangqi Chang, Jiong Bi, Shenming Wang, Wenjian Wang

Open Access Research article

Risk of cancer among HIV-infected patients from a population-based nested case–control study: implications for cancer prevention

Chang-Hua Chen, Chih-Yuan Chung, Li-Hsuan Wang, Che Lin, Hsiu-Li Lin, Hsiu-Chen Lin

Open Access Research article

Cyproheptadine, an antihistaminic drug, inhibits proliferation of hepatocellular carcinoma cells by blocking cell cycle progression through the activation of P38 MAP kinase

Yu-Min Feng, Chin-Wen Feng, Syue-Yi Chen, Hsiao-Yen Hsieh, Yu-Hsin Chen, Cheng-Da Hsu

Open Access Research article

Low levels of IGFBP7 expression in high-grade serous ovarian carcinoma is associated with patient outcome

Karen Gambaro, Michael CJ Quinn, Katia Y Cáceres-Gorriti, Rebecca S Shapiro, Diane Provencher, Kurosh Rahimi, Anne-Marie Mes-Masson, Patricia N Tonin

Open Access Research article

Dose-response relationship in cisplatin-treated breast cancer xenografts monitored with dynamic contrast-enhanced ultrasound

Yao Chen, Feng Han, Long-hui Cao, Cheng Li, Jian-wei Wang, Qing Li, Wei Zheng, Zhi-xing Guo, An-hua Li, Jian-hua Zhou

Open Access Research article

Alterations in anatomic and functional imaging parameters with repeated FDG PET-CT and MRI during radiotherapy for head and neck cancer: a pilot study

Manil Subesinghe, Andrew F Scarsbrook, Steven Sourbron, Daniel J Wilson, Garry McDermott, Richard Speight, Neil Roberts, Brendan Carey, Roan Forrester, Sandeep Vijaya Gopal, Jonathan R Sykes, Robin JD Prestwich

Open Access Research article

Poor prognosis of single hormone receptor- positive breast cancer: similar outcome as triple-negative breast cancer

Soo Youn Bae, Sangmin Kim, Jun Ho Lee, Hyun-chul Lee, Se Kyung Lee, Won Ho Kil, Seok Won Kim, Jeong Eon Lee, Seok Jin Nam

Open Access Research article

Annonaceous acetogenin mimic AA005 induces cancer cell death via apoptosis inducing factor through a caspase-3-independent mechanism

Bing Han, Tong-Dan Wang, Shao-Ming Shen, Yun Yu, Chan Mao, Zhu-Jun Yao, Li-Shun Wang

Open Access Research article

Phosphorylation of pyruvate kinase M2 and lactate dehydrogenase A by fibroblast growth factor receptor 1 in benign and malignant thyroid tissue

Paul Kachel, Bogusz Trojanowicz, Carsten Sekulla, Hanna Prenzel, Henning Dralle, Cuong Hoang-Vu

Open Access Commentary

Genomics driven-oncology: challenges and perspectives

Nicola Normanno, Ian A Cree

Open Access Research article

Detection of morphologic alterations in rectal carcinoma following preoperative radiochemotherapy based on multiphoton microscopy imaging

Lianhuang Li, Zhifen Chen, Xingfu Wang, Hongsheng Li, Weizhong Jiang, Shuangmu Zhuo, Guoxian Guan, Jianxin Chen

Open Access Research article

Associations between breast density and a panel of single nucleotide polymorphisms linked to breast cancer risk: a cohort study with digital mammography

Brad M Keller, Anne Marie McCarthy, Jinbo Chen, Katrina Armstrong, Emily F Conant, Susan M Domchek, Despina Kontos

Open Access Research article

HIV testing and burden of HIV infection in black cancer patients in Johannesburg, South Africa: a cross-sectional study

Mazvita Sengayi, Chantal Babb, Matthias Egger, Margaret I Urban

Open Access Research article

Critical evaluation of Cbx7 downregulation in primary colon carcinomas and its clinical significance in Chinese patients

Xiang Zheng, Jing Zhou, Baozhen Zhang, Jun Zhang, James Wilson, Liankun Gu, Budong Zhu, Jin Gu, Jiafu Ji, Dajun Deng

Open Access Research article

Prevalence and outcomes of extrahepatic primary malignancy associated with Hepatocellular Carcinoma in a Korean population

Sukho Hong, Sook-Hyang Jeong, Sang Soo Lee, Jung Wha Chung, Sung Wook Yang, Seong Min Chung, Eun Sun Jang, Jin-Wook Kim, Jee Hyun Kim, Haeryoung Kim, Jai Young Cho, Yoo-Seok Yoon, Ho-Seong Han

Open Access Research article

No significant viral transcription detected in whole breast cancer transcriptomes

Danai Fimereli, David Gacquer, Debora Fumagalli, Roberto Salgado, Françoise Rothé, Denis Larsimont, Christos Sotiriou, Vincent Detours

Open Access Research article

Prognostic role of serum p53 antibodies in lung cancer

Manlio Mattioni, Silvia Soddu, Andrea Prodosmo, Paolo Visca, Salvatore Conti, Gabriele Alessandrini, Francesco Facciolo, Lidia Strigari

Open Access Research article

Cancers of unknown primary origin (CUP) are characterized by chromosomal instability (CIN) compared to metastasis of know origin

Jonas Vikeså, Anne Kirstine H Møller, Bogumil Kaczkowski, Rehannah Borup, Ole Winther, Ricardo Henao, Anders Krogh, Katharina Perell, Flemming Jensen, Gedske Daugaard, Finn C Nielsen

Open Access Research article

Mechanisms of tumor-promoting activities of nicotine in lung cancer: synergistic effects of cell membrane and mitochondrial nicotinic acetylcholine receptors

Alex I Chernyavsky, Igor B Shchepotin, Valentin Galitovkiy, Sergei A Grando

Open Access Research article

Total and partial cancer prevalence in the adult French population in 2008

Marc Colonna, Nicolas Mitton, Nadine Bossard, Aurelien Belot, Pascale Grosclaude

Open Access Research article

Efficacy of pazopanib monotherapy in patients who had been heavily pretreated for metastatic soft tissue sarcoma: a retrospective case series

Kwai Han Yoo, Hyo Song Kim, Su Jin Lee, Se Hoon Park, Sung Joo Kim, Soo Hee Kim, Yoon La Choi, Kyoo-Ho Shin, Yong Jin Cho, Jeeyun Lee, Sun Young Rha

Open Access Research article

Prognostic relevance of positive urine markers in patients with negative cystoscopy during surveillance of bladder cancer

Tilman Todenhöfer, Jörg Hennenlotter, Philipp Guttenberg, Sarah Mohrhardt, Ursula Kuehs, Michael Esser, Stefan Aufderklamm, Simone Bier, Niklas Harland, Steffen Rausch, Georgios Gakis, Arnulf Stenzl, Christian Schwentner

Open Access Research article

Systematic review of the predictive effect of MSI status in colorectal cancer patients undergoing 5FU-based chemotherapy

Elizabeth M Webber, Tia L Kauffman, Elizabeth O’Connor, Katrina AB Goddard

Open Access Research article

A mutation screening of oncogenes, tumor suppressor gene TP53 and nuclear encoded mitochondrial complex I genes in oncocytic thyroid tumors

Cecilia Evangelisti, Dario de Biase, Ivana Kurelac, Claudio Ceccarelli, Holger Prokisch, Thomas Meitinger, Paola Caria, Roberta Vanni, Giovanni Romeo, Giovanni Tallini, Giuseppe Gasparre, Elena Bonora

Open Access Research article

Paired design study by real-time PCR: miR-378* and miR-145 are potent early diagnostic biomarkers of human colorectal cancer

Juan Peng, Zhengyong Xie, Liyang Cheng, Yuxin Zhang, Junyong Chen, Hongping Yu, Zehang Li, Huixing Kang

Open Access Research article

Anticancer activity of a thymidine quinoxaline conjugate is modulated by cytosolic thymidine pathways

Qiong Wei, Haijuan Liu, Honghao Zhou, Dejun Zhang, Zhiwei Zhang, Qibing Zhou

Open Access Research article

Heterogeneity analysis of Metastasis Associated in Colon Cancer 1 (MACC1) for survival prognosis of colorectal cancer patients: a retrospective cohort study

Viktor H Koelzer, Pia Herrmann, Inti Zlobec, Eva Karamitopoulou, Alessandro Lugli, Ulrike Stein

Open Access Research article

Induction of tumor initiation is dependent on CD44s in c-Met+ hepatocellular carcinoma

Hien Dang, Steven N Steinway, Wei Ding, Carl B Rountree

Open Access Research article

The impact of supplementary narrative-based information on colorectal cancer screening beliefs and intention

Lesley M McGregor, Christian von Wagner, Gemma Vart, Wing Chee Yuen, Rosalind Raine, Jane Wardle, Kathryn A Robb

Open Access Research article

Resolution of severe hyponatraemia is associated with improved survival in patients with cancer

Kirsty Balachandran, Alicia Okines, Ranga Gunapala, Daniel Morganstein, Sanjay Popat

Open Access Research article

The tumour-promoting receptor tyrosine kinase, EphB4, regulates expression of Integrin-β8 in prostate cancer cells

Inga Mertens-Walker, Bruno C Fernandini, Mohanan SN Maharaj, Anja Rockstroh, Colleen C Nelson, Adrian C Herington, Sally-Anne Stephenson

Open Access Study protocol

The efficacy and safety of irreversible electroporation for the ablation of renal masses: a prospective, human, in-vivo study protocol

Peter GK Wagstaff, Daniel M de Bruin, Patricia J Zondervan, C Dilara Savci Heijink, Marc RW Engelbrecht, Otto M van Delden, Ton G van Leeuwen, Hessel Wijkstra, Jean JMCH de la Rosette, M Pilar Laguna Pes

Open Access Research article

Overexpression of 17β-hydroxysteroid dehydrogenase type 10 increases pheochromocytoma cell growth and resistance to cell death

Emily A Carlson, Rebecca T Marquez, Fang Du, Yongfu Wang, Liang Xu, Shirley ShiDu Yan

Open Access Research article

Identifying a low-risk group for parametrial involvement in microscopic Stage IB1 cervical cancer using criteria from ongoing studies and a new MRI criterion

Jung-Yun Lee, Jina Youm, Jae-Weon Kim, Jeong Yeon Cho, Min A Kim, Tae Hun Kim, Dong Hoon Suh, Myong Cheol Lim, Noh Hyun Park, Yong-Sang Song

Open Access Research article

Prediction of long noncoding RNA functions with co-expression network in esophageal squamous cell carcinoma

Yibin Hao, Wei Wu, Fachun Shi, Rodrigo JS Dalmolin, Ming Yan, Fu Tian, Xiaobing Chen, Guoyong Chen, Wei Cao

Open Access Research article

Transcriptional expression of 8 genes predicts pathological response to first-line docetaxel + trastuzumab-based neoadjuvant chemotherapy

Esther Schmitt, Frédérique Végran, Sandy Chevrier, Laura Burillier, Muriel Cadouot, Sarab Lizard-Nacol, Bruno Coudert, Pierre Fumoleau, Laurent Arnould, Romain Boidot

Open Access Research article

A novel engineered VEGF blocker with an excellent pharmacokinetic profile and robust anti-tumor activity

Lily Liu, Haijia Yu, Xin Huang, Hongzhi Tan, Song Li, Yan Luo, Li Zhang, Sumei Jiang, Huifeng Jia, Yao Xiong, Ruliang Zhang, Yi Huang, Charles C Chu, Wenzhi Tian

Open Access Research article

A retrospective analysis of RET translocation, gene copy number gain and expression in NSCLC patients treated with vandetanib in four randomized Phase III studies

Adam Platt, John Morten, Qunsheng Ji, Paul Elvin, Chris Womack, Xinying Su, Emma Donald, Neil Gray, Jessica Read, Graham Bigley, Laura Blockley, Carl Cresswell, Angela Dale, Amanda Davies, Tianwei Zhang, Shuqiong Fan, Haihua Fu, Amanda Gladwin, Grace Harrod, James Stevens, Victoria Williams, Qingqing Ye, Li Zheng, Richard de Boer, Roy S Herbst, Jin-Soo Lee, James Vasselli

Open Access Research article

Ras induces experimental lung metastasis through up-regulation of RbAp46 to suppress RECK promoter activity

Hsuan-Heng Yeh, Yu-Fen Tseng, Yu-Chiao Hsu, Sheng-Hui Lan, Shan-Ying Wu, Giri Raghavaraju, Da-En Cheng, Ying-Ray Lee, Tsuey-Yu Chang, Nan-Haw Chow, Wen-Chun Hung, Hsiao-Sheng Liu

Open Access Erratum

Erratum: Preoperative chemosensitivity testing as Predictor of Treatment benefit in Adjuvant stage III colon cancer (PePiTA): Protocol of a prospective BGDO (Belgian Group for Digestive Oncology) multicentric study

Alain Hendlisz, Vassilis Golfinopoulos, Amelie Deleporte, Marianne Paesmans, Hazem El Mansy, Camilo Garcia, Marc Peeters, Lieven Annemans, Caroline Vandeputte, Marion Maetens, Marc Van den Eynde, Raphaël Maréchal, Ivan Borbath, Damien Dresse, Ghislain Houbiers, Michael Fried, Ahmad Awada, Martine Piccart, Jean-Luc Van Laethem, Patrick Flamen

Open Access Research

Photodynamic diagnosis of pleural malignant lesions with a combination of 5-aminolevulinic acid and intrinsic fluorescence observation systems

Masahiro Kitada, Yoshinobu Ohsaki, Yoshinari Matsuda, Satoshi Hayashi, Kei Ishibashi

Open Access Research article

A retrospective chart review of drug treatment patterns and clinical outcomes among patients with metastatic or recurrent soft tissue sarcoma refractory to one or more prior chemotherapy treatments

Michael J Wagner, Leo Ismaila Amodu, Mei Sheng Duh, Caroline Korves, Franco Solleza, Stephanie C Manson, José Diaz, Maureen P Neary, George D Demetri

Open Access Research article

Multicenter phase II study of FOLFIRI plus bevacizumab after discontinuation of oxaliplatin-based regimen for advanced or recurrent colorectal cancer (CR0802)

Mitsukuni Suenaga, Tomohiro Nishina, Nobuyuki Mizunuma, Hisateru Yasui, Takashi Ura, Tadamichi Denda, Junichi Ikeda, Taito Esaki, Hogara Nishisaki, Yoshinao Takano, Yasuyuki Sugiyama, Kei Muro

Open Access Research article

Dietary cadmium intake and risk of prostate cancer: a Danish prospective cohort study

Kirsten T Eriksen, Jytte Halkjær, Jaymie R Meliker, Jane A McElroy, Mette Sørensen, Anne Tjønneland, Ole Raaschou-Nielsen

Open Access Research article

Epithelial-mesenchymal plasticity is a decisive feature for the metastatic outgrowth of disseminated WAP-T mouse mammary carcinoma cells

Claudia Maenz, Eva Lenfert, Klaus Pantel, Udo Schumacher, Wolfgang Deppert, Florian Wegwitz

Open Access Research article

Evaluation of public cancer datasets and signatures identifies TP53 mutant signatures with robust prognostic and predictive value

Brian David Lehmann, Yan Ding, Daniel Joseph Viox, Ming Jiang, Yi Zheng, Wang Liao, Xi Chen, Wei Xiang, Yajun Yi

Open Access Study protocol

Neo-adjuvant chemotherapy followed by surgery versus surgery alone in high-risk patients with resectable colorectal liver metastases: the CHARISMA randomized multicenter clinical trial

Ninos Ayez, Eric P van der Stok, Hans de Wilt, Sandra A Radema, Richard van Hillegersberg, Rudi M Roumen, Gerard Vreugdenhil, Pieter J Tanis, Cornelis J Punt, Cornelis H Dejong, Rob L Jansen, Henk M Verheul, Koert P de Jong, Geke A Hospers, Joost M Klaase, Marie-Cecile Legdeur, Esther van Meerten, Ferry A Eskens, Nelly van der Meer, Bruno van der Holt, Cornelis Verhoef, Dirk J Grünhagen

Open Access Case report

BRCA1 germline mutation and glioblastoma development: report of cases

Meriem Boukerroucha, Claire Josse, Karin Segers, Sonia El-Guendi, Pierre Frères, Guy Jerusalem, Vincent Bours

Open Access Research article

Low mir-372 expression correlates with poor prognosis and tumor metastasis in hepatocellular carcinoma

Gang Wu, Yawei Wang, Xiaojun Lu, Hui He, Haiyang Liu, Xiangyu Meng, Shuguan Xia, Kunming Zheng, Boqian Liu

Open Access Case report

Breast cancer and neurofibromatosis type 1: a diagnostic challenge in patients with a high number of neurofibromas

André Vallejo Da Silva, Fabiana Resende Rodrigues, Mônica Pureza, Vania Gloria Silami Lopes, Karin Soares Cunha

Open Access Research article

Sorafenib inhibits intracellular signaling pathways and induces cell cycle arrest and cell death in thyroid carcinoma cells irrespective of histological origin or BRAF mutational status

Martina Broecker-Preuss, Stefan Müller, Martin Britten, Karl Worm, Kurt Werner Schmid, Klaus Mann, Dagmar Fuhrer

Open Access Research article

A population-based study of incidence and patient survival of small cell carcinoma in the United States, 1992–2010

Graça M Dores, Osama Qubaiah, Ankur Mody, Bassam Ghabach, Susan S Devesa

Open Access Research article

Factors influencing participation in a randomized controlled resistance exercise intervention study in breast cancer patients during radiotherapy

Sandra M Gollhofer, Joachim Wiskemann, Martina E Schmidt, Oliver Klassen, Cornelia M Ulrich, Jan Oelmann, Holger Hof, Karin Potthoff, Karen Steindorf

Open Access Research article

The role of multipotent cancer associated fibroblasts in hepatocarcinogenesis

Caecilia Hapsari Ceriapuri Sukowati, Beatrice Anfuso, Lory Saveria Crocé, Claudio Tiribelli

Open Access Research article

NPC1L1 knockout protects against colitis-associated tumorigenesis in mice

Jianming He, Hyunsu Shin, Xing Wei, Anil Kumar G Kadegowda, Rui Chen, Sandy Krystal Xie

Open Access Research article

The role of androgen deprivation therapy on biochemical failure and distant metastasis in intermediate-risk prostate cancer: effects of radiation dose escalation

Michelle S Ludwig, Deborah A Kuban, Xianglin L Du, David S Lopez, Jose-Miguel Yamal, Sara S Strom

Open Access Research article

Residential environment and breast cancer incidence and mortality: a systematic review and meta-analysis

Tomi F Akinyemiju, Jeanine M Genkinger, Maggie Farhat, Adrienne Wilson, Tiffany L Gary-Webb, Parisa Tehranifar

Open Access Study protocol

Ion therapy within the trimodal management of superior sulcus tumors: the INKA trial

Henrik Hauswald, Stefan Rieken, Hendrik C Dienemann, Michael Thomas, Meinhard Kieser, Jürgen Debus, Klaus Herfarth

Open Access Research article

Feasibility of urinary microRNA detection in breast cancer patients and its potential as an innovative non-invasive biomarker

Thalia Erbes, Marc Hirschfeld, Gerta Rücker, Markus Jaeger, Jasmin Boas, Severine Iborra, Sebastian Mayer, Gerald Gitsch, Elmar Stickeler

Open Access Research article

Association between CHEK2 H371Y mutation and response to neoadjuvant chemotherapy in women with breast cancer

Yin Liu, Ye Xu, Tao Ouyang, Jinfeng Li, Tianfeng Wang, Zhaoqing Fan, Tie Fan, Benyao Lin, Yuntao Xie

Open Access Research article

Pre-treatment neutrophil to lymphocyte ratio may be a useful tool in predicting survival in early triple negative breast cancer patients

Mirco Pistelli, Mariagrazia De Lisa, Zelmira Ballatore, Miriam Caramanti, Alessandra Pagliacci, Nicola Battelli, Francesca Ridolfi, Matteo Santoni, Elena Maccaroni, Raffaella Bracci, Alfredo Santinelli, Tommasina Biscotti, Rossana Berardi, Stefano Cascinu

Open Access Research article

Topotecan synergizes with CHEK1 (CHK1) inhibitor to induce apoptosis in ovarian cancer cells

Marianne K Kim, Jana James, Christina M Annunziata

Open Access Research article

Sumoylation of Kif18A plays a role in regulating mitotic progression

Feikun Yang, Yan Chen, Wei Dai

Open Access Research article

Prognostic significance of interim PET/CT based on visual, SUV-based, and MTV-based assessment in the treatment of peripheral T-cell lymphoma

Sung-Hoon Jung, Jae-Sook Ahn, Yeo-Kyeoung Kim, Sun-Seog Kweon, Jung-Joon Min, Hee-Seung Bom, Hyeoung-Joon Kim, Yee Soo Chae, Joon Ho Moon, Sang Kyun Sohn, Sang Woo Lee, Byung Hyun Byun, Young Rok Do, Je-Jung Lee, Deok-Hwan Yang

Open Access Technical advance

A multiplexed, targeted mass spectrometry assay of the S100 protein family uncovers the isoform-specific expression in thyroid tumours

Juan Martínez-Aguilar, Roderick Clifton-Bligh, Mark P Molloy

Open Access Research article

The leukemia inhibitory factor (LIF) and p21 mediate the TGFβ tumor suppressive effects in human cutaneous melanoma

Laure Humbert, Mostafa Ghozlan, Lucie Canaff, Jun Tian, Jean-Jacques Lebrun

Open Access Research article

Luminal B subtype: A key factor for the worse prognosis of young breast cancer patients in China

Li-Chen Tang, Xi Jin, Hai-Yuan Yang, Min He, Helena Chang, Zhi-Ming Shao, Gen-Hong Di

Open Access Research article

Meta-analysis of the prognostic value of circulating tumor cells detected with the CellSearch System in colorectal cancer

Xuanzhang Huang, Peng Gao, Yongxi Song, Jingxu Sun, Xiaowan Chen, Junhua Zhao, Huimian Xu, Zhenning Wang

Open Access Research article

MTUS1/ATIP3a down-regulation is associated with enhanced migration, invasion and poor prognosis in salivary adenoid cystic carcinoma

Tingting Zhao, Xueqiang Ding, Boyang Chang, Xiaofeng Zhou, Anxun Wang

Open Access Research article

Androgen receptor and chemokine receptors 4 and 7 form a signaling axis to regulate CXCL12-dependent cellular motility

Jordy J Hsiao, Brandon H Ng, Melinda M Smits, Jiahui Wang, Rohini J Jasavala, Harryl D Martinez, Jinhee Lee, Jhullian J Alston, Hiroaki Misonou, James S Trimmer, Michael E Wright

Open Access Research article

Homozygous deletions of UGT2B17 modifies effects of smoking on TP53-mutations and relapse of head and neck carcinoma

Aki Mafune, Takanori Hama, Toshihito Suda, Yutaka Suzuki, Masahiro Ikegami, Chikako Sakanashi, Satoko Imai, Akio Nakashima, Takashi Yokoo, Kota Wada, Hiromi Kojima, Mitsuyoshi Urashima

Open Access Research article

Circulating tumor cells in hepatocellular carcinoma: a pilot study of detection, enumeration, and next-generation sequencing in cases and controls

Robin K Kelley, Mark Jesus M Magbanua, Timothy M Butler, Eric A Collisson, Jimmy Hwang, Nikoletta Sidiropoulos, Kimberley Evason, Ryan M McWhirter, Bilal Hameed, Elizabeth M Wayne, Francis Y Yao, Alan P Venook, John W Park

Open Access Research article

NQO1 protein expression predicts poor prognosis of non-small cell lung cancers

Zhenling Li, Yue Zhang, Tiefeng Jin, Jiguang Men, Zhenhua Lin, Peng Qi, Yingshi Piao, Guanghai Yan

Open Access Research article

Murine double minute 2 predicts response of advanced esophageal squamous cell carcinoma to definitive chemoradiotherapy

Hiroshi Okamoto, Fumiyoshi Fujishima, Takashi Kamei, Yasuhiro Nakamura, Yohei Ozawa, Go Miyata, Toru Nakano, Kazunori Katsura, Shigeo Abe, Yusuke Taniyama, Tadashi Sakurai, Jin Teshima, Makoto Hikage, Hironobu Sasano, Noriaki Ohuchi

Open Access Research article

Prognostic value of carbonic anhydrase VII expression in colorectal carcinoma

Guang-Zhen Yang, Liang Hu, Jian Cai, Hai-Yang Chen, Yu Zhang, Dan Feng, Chen-Ye Qi, Yan-Xia Zhai, Hui Gong, Hao Fu, Qing-Ping Cai, Chun-Fang Gao

Open Access Research article

Treatment and survival of non-alcoholic steatohepatitis associated hepatocellular carcinoma

Arndt Weinmann, Yvonne Alt, Sandra Koch, Carina Nelles, Christoph Düber, Hauke Lang, Gerd Otto, Tim Zimmermann, Jens U Marquardt, Peter R Galle, Marcus A Wörns, Jörn M Schattenberg

Open Access Research article

Effects of payer status on breast cancer survival: a retrospective study

Runhua Shi, Hannah Taylor, Jerry McLarty, Lihong Liu, Glenn Mills, Gary Burton

Open Access Research article

Lack of a protective effect of cotton dust on risk of lung cancer: evidence from two population-based case-control studies

Krista Yorita Christensen, Jérôme Lavoué, Marie-Claude Rousseau, Jack Siemiatycki

Open Access Research article

Availability and outcomes of radiotherapy in Central Poland during the 2005-2012 period - an observational study

Justyna Chalubinska-Fendler, Wojciech Fendler, Michal Spych, Jolanta Luniewska-Bury, Wojciech Mlynarski, Jacek Fijuth

Open Access Technical advance

Development and analytical validation of a 25-gene next generation sequencing panel that includes the BRCA1 and BRCA2 genes to assess hereditary cancer risk

Thaddeus Judkins, Benoît Leclair, Karla Bowles, Natalia Gutin, Jeff Trost, James McCulloch, Satish Bhatnagar, Adam Murray, Jonathan Craft, Bryan Wardell, Mark Bastian, Jeffrey Mitchell, Jian Chen, Thanh Tran, Deborah Williams, Jennifer Potter, Srikanth Jammulapati, Michael Perry, Brian Morris, Benjamin Roa, Kirsten Timms

Open Access Research article

Direct confirmation of quiescence of CD34+CD38- leukemia stem cell populations using single cell culture, their molecular signature and clinicopathological implications

Eun Jeong Won, Hye-Ran Kim, Ra-Young Park, Seok-Yong Choi, Jong Hee Shin, Soon-Pal Suh, Dong-Wook Ryang, Michael Szardenings, Myung-Geun Shin

Open Access Research article

Improvement of the initial management of sarcomas after the dissemination of evidence-based guidelines depends on the primary sarcoma location: a population-based study

Karine Ligier, Carlos Maynou, Xavier Leroy, Yves-Marie Robin, Philippe Martin, Stéphanie Clisant, Florence Richard, Nicolas Penel

Open Access Research article

BRCA1 Alternative splicing landscape in breast tissue samples

Atocha Romero, Francisco García-García, Irene López-Perolio, Gorka Ruiz de Garibay, José A García-Sáenz, Pilar Garre, Patricia Ayllón, Esperanza Benito, Joaquín Dopazo, Eduardo Díaz-Rubio, Trinidad Caldés, Miguel de la Hoya

Open Access Research article

The role of histologic subtype, p16INK4a expression, and presence of human papillomavirus DNA in penile squamous cell carcinoma

Julie Steinestel, Andreas Al Ghazal, Annette Arndt, Thomas J Schnoeller, Andres J Schrader, Peter Moeller, Konrad Steinestel

Open Access Research article

A pooled shRNA screen for regulators of primary mammary stem and progenitor cells identifies roles for Asap1 and Prox1

Julie M Sheridan, Matthew E Ritchie, Sarah A Best, Kun Jiang, Tamara J Beck, François Vaillant, Kevin Liu, Ross A Dickins, Gordon K Smyth, Geoffrey J Lindeman, Jane E Visvader

Open Access Research article

Abiraterone acetate in patients with metastatic castration-resistant prostate cancer: long term outcome of the Temporary Authorization for Use programme in France

Nadine Houédé, Philippe Beuzeboc, Sophie Gourgou, Diego Tosi, Laura Moise, Gwenaëlle Gravis, Remy Delva, Aude Fléchon, Igor Latorzeff, Jean-Marc Ferrero, Stéphane Oudard, Sophie Tartas, Brigitte Laguerre, Delphine Topart, Guilhem Roubaud, Hanane Agherbi, Xavier Rebillard, David Azria

Open Access Research article

Human pancreatic cancer stem cells are sensitive to dual inhibition of IGF-IR and ErbB receptors

Nerea Urtasun, Anna Vidal-Pla, Sandra Pérez-Torras, Adela Mazo

Open Access Research article

Chemoresistance is associated with increased cytoprotective autophagy and diminished apoptosis in bladder cancer cells treated with the BH3 mimetic (−)-Gossypol (AT-101)

Jens Mani, Stefan Vallo, Stefanie Rakel, Patrick Antonietti, Florian Gessler, Roman Blaheta, Georg Bartsch, Martin Michaelis, Jindrich Cinatl, Axel Haferkamp, Donat Kögel

Open Access Research article

γ-Glutamyl transferase 7 is a novel regulator of glioblastoma growth

Timothy T Bui, Ryan T Nitta, Suzana A Kahn, Seyed-Mostafa Razavi, Maya Agarwal, Parvir Aujla, Sharareh Gholamin, Lawrence Recht, Gordon Li

Open Access Research article

Role of the splicing factor SRSF4 in cisplatin-induced modifications of pre-mRNA splicing and apoptosis

Maude Gabriel, Yves Delforge, Adeline Deward, Yvette Habraken, Benoit Hennuy, Jacques Piette, Roscoe Klinck, Benoit Chabot, Alain Colige, Charles Lambert

Open Access Research article

In vitro and in vivo antiproliferative activity of metformin on stem-like cells isolated from spontaneous canine mammary carcinomas: translational implications for human tumors

Federica Barbieri, Stefano Thellung, Alessandra Ratto, Elisa Carra, Valeria Marini, Carmen Fucile, Adriana Bajetto, Alessandra Pattarozzi, Roberto Würth, Monica Gatti, Chiara Campanella, Guendalina Vito, Francesca Mattioli, Aldo Pagano, Antonio Daga, Angelo Ferrari, Tullio Florio

Open Access Research article

HNF1B polymorphism influences the prognosis of endometrial cancer patients: a cohort study

Vincenzo Dario Mandato, Enrico Farnetti, Federica Torricelli, Martino Abrate, Bruno Casali, Gino Ciarlini, Debora Pirillo, Maria Carolina Gelli, Davide Nicoli, Mario Grassi, Giovanni Battista LA Sala, Stefano Palomba

Open Access Research article

HPV-16 impairs the subcellular distribution and levels of expression of protein phosphatase 1γ in cervical malignancy

Takayuki Seiki, Kazunori Nagasaka, Christian Kranjec, Kei Kawana, Daichi Maeda, Hiroe Nakamura, Ayumi Taguchi, Yoko Matsumoto, Takahide Arimoto, Osamu Wada-Hiraike, Katsutoshi Oda, Shunsuke Nakagawa, Tetsu Yano, Masashi Fukayama, Lawrence Banks, Yutaka Osuga, Tomoyuki Fujii

Open Access Research article

Changing the clinical course of glioma patients by preoperative motor mapping with navigated transcranial magnetic brain stimulation

Sandro M Krieg, Nico Sollmann, Thomas Obermueller, Jamil Sabih, Lucia Bulubas, Chiara Negwer, Tobias Moser, Doris Droese, Tobias Boeckh-Behrens, Florian Ringel, Bernhard Meyer

Open Access Research article

Effect of liver transplantation in combined hepatocellular and cholangiocellular carcinoma: a case series

Di Wu, Zhong-Yang Shen, Ya-Min Zhang, Jian Wang, Hong Zheng, Yong-Lin Deng, Cheng Pan

Open Access Study protocol

eCROPS-CA: a systematic approach toward effective and sustainable cancer prevention in rural China

Jing Chai, Xingrong Shen, Rui Feng, Jing Cheng, Yeji Chen, Zhengqiu Zha, Shangchun Jia, Han Liang, Ting Zhao, Rui Sha, Yong Shi, Kaichun Li, Debin Wang

Open Access Research article

Vascular dysfunction and increased metastasis of B16F10 melanomas in Shb deficient mice as compared with their wild type counterparts

Guangxiang Zang, Karin Gustafsson, Maria Jamalpour, JongWook Hong, Guillem Genové, Michael Welsh

Open Access Research article

Predicting response to multidrug regimens in cancer patients using cell line experiments and regularised regression models

Steffen Falgreen, Karen Dybkær, Ken H Young, Zijun Y Xu-Monette, Tarec C El-Galaly, Maria Bach Laursen, Julie S Bødker, Malene K Kjeldsen, Alexander Schmitz, Mette Nyegaard, Hans Erik Johnsen, Martin Bøgsted

Open Access Research article

Clinical outcomes of patients with advanced hepatocellular carcinoma treated with sorafenib: a retrospective study of routine clinical practice in multi-institutions

Sae Hwan Lee, Il Han Song, Ran Noh, Ha Yan Kang, Suk Bae Kim, Soon Young Ko, Eoum Seok Lee, Seok Hyun Kim, Byung Seok Lee, An Na Kim, Hee Bok Chae, Hong Soo Kim, Tae Hee Lee, Young Woo Kang, Jae Dong Lee, Heon Young Lee

Open Access Study protocol

Treatment of advanced gastrointestinal tumors with genetically modified autologous mesenchymal stromal cells (TREAT-ME1): study protocol of a phase I/II clinical trial

Hanno Niess, Jobst C von Einem, Michael N Thomas, Marlies Michl, Martin K Angele, Ralf Huss, Christine Günther, Peter J Nelson, Christiane J Bruns, Volker Heinemann

Open Access Research article

MicroRNA-223 is a novel negative regulator of HSP90B1 in CLL

Ana E Rodríguez-Vicente, Dalia Quwaider, Rocío Benito, Irena Misiewicz-Krzeminska, María Hernández-Sánchez, Alfonso García de Coca, Rosa Fisac, José-María Alonso, Carolina Zato, Juan Francisco de Paz, Juan Luis García, Ma Eugenia Sarasquete, José Ángel Hernández, Juan M Corchado, Marcos González, Norma C Gutiérrez, Jesús-María Hernández-Rivas

Open Access Research article

Aurora kinase B is important for antiestrogen resistant cell growth and a potential biomarker for tamoxifen resistant breast cancer

Sarah L Larsen, Christina W Yde, Anne-Vibeke Laenkholm, Birgitte B Rasmussen, Anne Katrine Duun-Henriksen, Martin Bak, Anne E Lykkesfeldt, Tove Kirkegaard

Open Access Research article

HGUE-C-1 is an atypical and novel colon carcinoma cell line

Silvina Grasso, Isabel Martínez-Lacaci, Víctor Manuel Barberá, Adela Castillejo, José Luis Soto, Javier Gallego-Plazas, Natividad López-Riquelme, Pilar García-Morales, Trinidad Mata-Balaguer, José Antonio Ferragut, Miguel Saceda

Open Access Research article

Control of the MYC-eIF4E axis plus mTOR inhibitor treatment in small cell lung cancer

Masaru Matsumoto, Masahiro Seike, Rintaro Noro, Chie Soeno, Teppei Sugano, Susumu Takeuchi, Akihiko Miyanaga, Kazuhiro Kitamura, Kaoru Kubota, Akihiko Gemma

Open Access Research article

DNA copy number analysis of metastatic urothelial carcinoma with comparison to primary tumors

Richard M Bambury, Ami S Bhatt, Markus Riester, Chandra Sekhar Pedamallu, Fujiko Duke, Joaquim Bellmunt, Edward C Stack, Lillian Werner, Rachel Park, Gopa Iyer, Massimo Loda, Philip W Kantoff, Franziska Michor, Matthew Meyerson, Jonathan E Rosenberg

Open Access Research article

General Practitioners and Breast Surgeons in France, Germany, Netherlands and the UK show variable breast cancer risk communication profiles

Claire Julian-Reynier, Anne-Deborah Bouhnik, D Gareth Evans, Hilary Harris, Christi J van Asperen, Aad Tibben, Joerg Schmidtke, Irmgard Nippert

Open Access Research article

High expression of NQO1 is associated with poor prognosis in serous ovarian carcinoma

Xuelian Cui, Lianhua Li, Guanghai Yan, Kai Meng, Zhenhua Lin, Yunze Nan, Guang Jin, Chunyu Li

Open Access Research article

TLR3 expression correlates with apoptosis, proliferation and angiogenesis in hepatocellular carcinoma and predicts prognosis

Ming-Ming Yuan, Yu-Yin Xu, Li Chen, Xing-Yu Li, Jing Qin, Ying Shen

Open Access Research article

Serine threonine tyrosine kinase 1 is a potential prognostic marker in colorectal cancer

Liang Hu, Hai-Yang Chen, Jian Cai, Yu Zhang, Chen-Ye Qi, Hui Gong, Yan-Xia Zhai, Hao Fu, Guang-Zhen Yang, Chun-Fang Gao

Open Access Case report

Oxaliplatin toxicity presenting as a liver nodule – case report

Henrique Alexandrino, Domingos Oliveira, Maria Augusta Cipriano, Luís Ferreira, J Guilherme Tralhão, Francisco Castro e Sousa

Open Access Research article

Oridonin stabilizes retinoic acid receptor alpha through ROS-activated NF-κB signaling

Yang Cao, Wei Wei, Nan Zhang, Qing Yu, Wen-Bin Xu, Wen-Jun Yu, Guo-Qiang Chen, Ying-Li Wu, Hua Yan

Open Access Research article

Characteristics of attitude and recommendation of oncologists toward exercise in South Korea: a cross sectional survey study

Ji-Hye Park, Minsuk Oh, Yong Jin Yoon, Chul Won Lee, Lee W Jones, Seung Il Kim, Nam Kyu Kim, Justin Y Jeon

Open Access Research article

Curcumin potentiates antitumor activity of 5-fluorouracil in a 3D alginate tumor microenvironment of colorectal cancer

Mehdi Shakibaei, Patricia Kraehe, Bastian Popper, Parviz Shayan, Ajay Goel, Constanze Buhrmann

Open Access Research article

Combined comparative genomic hybridization and transcriptomic analyses of ovarian granulosa cell tumors point to novel candidate driver genes

Sandrine Caburet, Mikko Anttonen, Anne-Laure Todeschini, Leila Unkila-Kallio, Denis Mestivier, Ralf Butzow, Reiner A Veitia

Open Access Research article

Confocal laser endomicroscopy in breast surgery: a pilot study

Giovanni D De Palma, Dario Esposito, Gaetano Luglio, Gennaro Limite, Antonello Accurso, Viviana Sollazzo, Francesco Maione, Gianluca Cassese, Saverio Siciliano, Nicola Gennarelli, Gennaro Ilardi, Mariano Paternoster, Mariano C Giglio, Pietro Forestieri

Open Access Research article

Safety and feasibility of adjuvant chemotherapy with S-1 in Japanese breast cancer patients after primary systemic chemotherapy: a feasibility study

Takashi Shigekawa, Akihiko Osaki, Hiroshi Sekine, Nobuaki Sato, Chizuko Kanbayashi, Hiroshi Sano, Hideki Takeuchi, Shigeto Ueda, Noriko Nakamiya, Ikuko Sugitani, Michiko Sugiyama, Hiroko Shimada, Eiko Hirokawa, Takao Takahashi, Toshiaki Saeki

Open Access Research article

The natural compound Guttiferone F sensitizes prostate cancer to starvation induced apoptosis via calcium and JNK elevation

Xin Li, Yuanzhi Lao, Hong Zhang, Xiaoyu Wang, Hongsheng Tan, Zhixiu Lin, Hongxi Xu

Open Access Research article

Combined treatment of Nimotuzumab and rapamycin is effective against temozolomide-resistant human gliomas regardless of the EGFR mutation status

Dawn Q Chong, Xin Y Toh, Ivy AW Ho, Kian C Sia, Jennifer P Newman, Yulyana Yulyana, Wai-Hoe Ng, Siang H Lai, Mac MF Ho, Nivedh Dinesh, Chee K Tham, Paula YP Lam

Open Access Research article

Remodeling of extracellular matrix by normal and tumor-associated fibroblasts promotes cervical cancer progression

Alexandra Fullár, József Dudás, Lászlóné Oláh, Péter Hollósi, Zoltán Papp, Gábor Sobel, Katalin Karászi, Sándor Paku, Kornélia Baghy, Ilona Kovalszky

Open Access Research article

A retrospective observational study of clinicopathological features of KRAS, NRAS, BRAF and PIK3CA mutations in Japanese patients with metastatic colorectal cancer

Akihito Kawazoe, Kohei Shitara, Shota Fukuoka, Yasutoshi Kuboki, Hideaki Bando, Wataru Okamoto, Takashi Kojima, Nozomu Fuse, Takeharu Yamanaka, Toshihiko Doi, Atsushi Ohtsu, Takayuki Yoshino

Open Access Research article

Novel non-invasive biomarkers that distinguish between benign prostate hyperplasia and prostate cancer

Andrej Jedinak, Adam Curatolo, David Zurakowski, Simon Dillon, Manoj K Bhasin, Towia A Libermann, Roopali Roy, Monisha Sachdev, Kevin R Loughlin, Marsha A Moses

Open Access Research article

Identification of a unique hepatocellular carcinoma line, Li-7, with CD13(+) cancer stem cells hierarchy and population change upon its differentiation during culture and effects of sorafenib

Takeshi Yamada, Masato Abei, Inaho Danjoh, Ryoko Shirota, Taro Yamashita, Ichinosuke Hyodo, Yukio Nakamura

Open Access Research article

The impact of preoperative language mapping by repetitive navigated transcranial magnetic stimulation on the clinical course of brain tumor patients

Nico Sollmann, Sebastian Ille, Theresa Hauck, Stefanie Maurer, Chiara Negwer, Claus Zimmer, Florian Ringel, Bernhard Meyer, Sandro M Krieg

Open Access Research article

Cyclin D1 sensitizes myeloma cells to endoplasmic reticulum stress-mediated apoptosis by activating the unfolded protein response pathway

Sophie Bustany, Julie Cahu, Philippe Guardiola, Brigitte Sola

Open Access Research article

The role of clinically significant portal hypertension in hepatic resection for hepatocellular carcinoma patients: a propensity score matching analysis

Wei He, Qingli Zeng, Yun Zheng, Meixian Chen, Jingxian Shen, Jiliang Qiu, Miao Chen, Ruhai Zou, Yadi Liao, Qijiong Li, Xianqiu Wu, Binkui Li, Yunfei Yuan

Open Access Research article

Copy number gain of granulin-epithelin precursor (GEP) at chromosome 17q21 associates with overexpression in human liver cancer

Man Kuen Yung, Kwok Wai Lo, Chi Wai Yip, Grace TY Chung, Carol YK Tong, Phyllis FY Cheung, Tan To Cheung, Ronnie TP Poon, Samuel So, Sheung Tat Fan, Siu Tim Cheung

Open Access Research article

Feasibility of self-sampled dried blood spot and saliva samples sent by mail in a population-based study

Amrit Kaur Sakhi, Nasser Ezzatkhah Bastani, Merete Ellingjord-Dale, Thomas Erik Gundersen, Rune Blomhoff, Giske Ursin

Open Access Research article

The involvement of insulin-like growth factor 2 binding protein 3 (IMP3) in pancreatic cancer cell migration, invasion, and adhesion

Clarissa C Pasiliao, Che-Wei A Chang, Brent W Sutherland, Shannon M Valdez, David Schaeffer, Donald T Yapp, Sylvia S W Ng

Open Access Research article

Pro1170 Ala polymorphism in HER2-neu is associated with risk of trastuzumab cardiotoxicity

Sasha E Stanton, Maureen M Ward, Paul Christos, Rachel Sanford, Christina Lam, Marta V Cobham, Diana Donovan, Ronald J Scheff, Tessa Cigler, Anne Moore, Linda T Vahdat, Maureen E Lane, Ellen Chuang

Open Access Research article

Perceived causes and consequences of sexual changes after cancer for women and men: a mixed method study

Jane M Ussher, Janette Perz, Emilee Gilbert

Open Access Research article

Gangliocytic paraganglioma: a multi-institutional retrospective study in Japan

Yoichiro Okubo, Tetsuo Nemoto, Megumi Wakayama, Naobumi Tochigi, Minoru Shinozaki, Takao Ishiwatari, Kyoko Aki, Masaru Tsuchiya, Hajime Aoyama, Kanade Katsura, Takeshi Fujii, Takashi Nishigami, Tomoyuki Yokose, Yasuo Ohkura, Kazutoshi Shibuya

Open Access Research article

Management and prognosis of patients with ovarian sex cord tumor with annular tubules: a retrospective study

Qiuhong Qian, Yan You, Jiaxin Yang, Dongyan Cao, Zhaohui Zhu, Ming Wu, Jie Chen, Jinghe Lang, Keng Shen

Open Access Case report

Colorectal liver metastases: making the unresectable resectable using irreversible electroporation for microscopic positive margins – a case report

Hans F Schoellhammer, Bryan Goldner, Shaila J Merchant, Jonathan Kessler, Yuman Fong, Singh Gagandeep

Open Access Research article

Lower PRDM2 expression is associated with dopamine-agonist resistance and tumor recurrence in prolactinomas

Hua Gao, Fei Wang, Xiaolei Lan, Chuzhong Li, Jie Feng, Jiwei Bai, Lei Cao, Songbai Gui, Lichuan Hong, Yazhuo Zhang

Open Access Research article

DNA methylation and histone modifications regulate SOX11 expression in lymphoid and solid cancer cells

Lena Nordström, Elin Andersson, Venera Kuci, Elin Gustavsson, Karolina Holm, Markus Ringnér, Per Guldberg, Sara Ek

Open Access Research article

Inter-observer agreement according to three methods of evaluating mammographic density and parenchymal pattern in a case control study: impact on relative risk of breast cancer

Rikke Rass Winkel, My von Euler-Chelpin, Mads Nielsen, Pengfei Diao, Michael Bachmann Nielsen, Wei Yao Uldall, Ilse Vejborg

Open Access Research article

Loss of AF-6/afadin induces cell invasion, suppresses the formation of glandular structures and might be a predictive marker of resistance to chemotherapy in endometrial cancer

Takuro Yamamoto, Taisuke Mori, Morio Sawada, Hiroshi Matsushima, Fumitake Ito, Makoto Akiyama, Jo Kitawaki

Open Access Research article

Discovery and anti-cancer evaluation of two novel non-ATP-competitive FGFR1 inhibitors in non-small-cell lung cancer

Jianzhang Wu, Tao Wei, Qinqin Tang, Bixia Weng, Wulan Li, Xin Jiang, Ting Ding, Xiaokun Li, Guang Liang, Yuepiao Cai, Jiansong Ji

Open Access Research article

ACTN4 and the pathways associated with cell motility and adhesion contribute to the process of lung cancer metastasis to the brain

Yufei Gao, Guanghu Li, Liankun Sun, Yichun He, Xiaoyan Li, Zhi Sun, Jihan Wang, Yang Jiang, Jingwei Shi

Open Access Research article

Association of high obesity with PAM50 breast cancer intrinsic subtypes and gene expression

Marilyn L Kwan, Candyce H Kroenke, Carol Sweeney, Philip S Bernard, Erin K Weltzien, Adrienne Castillo, Rachel E Factor, Kaylynn S Maxfield, Inge J Stijleman, Lawrence H Kushi, Charles P Quesenberry Jr., Laurel A Habel, Bette J Caan

Open Access Research article

The implementation of an organised cervical screening programme in Poland: an analysis of the adherence to European guidelines

Andrzej Nowakowski, Marek Cybulski, Andrzej Śliwczyński, Arkadiusz Chil, Zbigniew Teter, Przemysław Seroczyński, Marc Arbyn, Ahti Anttila

Open Access Research article

Improving the assessment of quality of life in the clinical care of myeloma patients: the development and validation of the Myeloma Patient Outcome Scale (MyPOS)

Thomas R Osborne, Christina Ramsenthaler, Stephen A Schey, Richard J Siegert, Polly M Edmonds, Irene J Higginson

Open Access Study protocol

Multiparametric MRI as an outcome predictor for anal canal cancer managed with chemoradiotherapy

Michael Jones, George Hruby, Peter Stanwell, Sarah Gallagher, Karen Wong, Jameen Arm, Jarad Martin

Open Access Research article

Clinicopathological study of centrally necrotizing carcinoma of the breast

Yanling Zhang, Yurong Ou, Donghong Yu, Xiang Yong, Xiaoli Wang, Bo Zhu, Qiong Zhang, Lei Zhou, Zhaogen Cai, Zenong Cheng

Open Access Research article

Impact of kinesin Eg5 inhibition by 3,4-dihydropyrimidin-2(1H)-one derivatives on various breast cancer cell features

Bruna C Guido, Luciana M Ramos, Diego O Nolasco, Catharine C Nobrega, Bárbara YG Andrade, Aline Pic-Taylor, Brenno AD Neto, José R Corrêa

Open Access Research article

A new relative tumor sizing method in epi-metaphyseal osteosarcoma

Seung Hyun Kim, Kyoo-Ho Shin, Eun Hae Park, Yong Jin Cho, Byoung-Kyu Park, Jin-Suck Suh, Woo-Ick Yang

Open Access Research article

Altered PPP2R2A and Cyclin D1 expression defines a subgroup of aggressive luminal-like breast cancer

Francisco Beca, Miguel Pereira, Jorge F Cameselle-Teijeiro, Diana Martins, Fernando Schmitt

Open Access Research article

Epidemiological patterns of asbestos exposure and spatial clusters of incident cases of malignant mesothelioma from the Italian national registry

Marisa Corfiati, Alberto Scarselli, Alessandra Binazzi, Davide Di Marzio, Marina Verardo, Dario Mirabelli, Valerio Gennaro, Carolina Mensi, Gert Schallemberg, Enzo Merler, Corrado Negro, Antonio Romanelli, Elisabetta Chellini, Stefano Silvestri, Mario Cocchioni, Cristiana Pascucci, Fabrizio Stracci, Elisa Romeo, Luana Trafficante, Italo Angelillo, Simona Menegozzo, Marina Musti, Domenica Cavone, Gabriella Cauzillo, Federico Tallarigo, Rosario Tumino, Massimo Melis, Sergio Iavicoli, Alessandro Marinaccio

Open Access Research article

The end of the decline in cervical cancer mortality in Spain: trends across the period 1981–2012

Marta Cervantes-Amat, Gonzalo López-Abente, Nuria Aragonés, Marina Pollán, Roberto Pastor-Barriuso, Beatriz Pérez-Gómez

Open Access Research article

A longitudinal study of non-medical determinants of adherence to R-CHOP therapy for diffuse large B-cell lymphoma: implication for survival

Cécile Borel, Sébastien Lamy, Gisèle Compaci, Christian Récher, Pauline Jeanneau, Jean Claude Nogaro, Eric Bauvin, Fabien Despas, Cyrille Delpierre, Guy Laurent

Open Access Research article

Platelets enhance tissue factor protein and metastasis initiating cell markers, and act as chemoattractants increasing the migration of ovarian cancer cells

Renan Orellana, Sumie Kato, Rafaela Erices, María Loreto Bravo, Pamela Gonzalez, Bárbara Oliva, Sofía Cubillos, Andrés Valdivia, Carolina Ibañez, Jorge Brañes, María Isabel Barriga, Erasmo Bravo, Catalina Alonso, Eva Bustamente, Enrique Castellon, Patricia Hidalgo, Cesar Trigo, Olga Panes, Jaime Pereira, Diego Mezzano, Mauricio A Cuello, Gareth I Owen

Open Access Research article

Massively parallel sequencing fails to detect minor resistant subclones in tissue samples prior to tyrosine kinase inhibitor therapy

Carina Heydt, Niklas Kumm, Jana Fassunke, Helen Künstlinger, Michaela Angelika Ihle, Andreas Scheel, Hans-Ulrich Schildhaus, Florian Haller, Reinhard Büttner, Margarete Odenthal, Eva Wardelmann, Sabine Merkelbach-Bruse

Open Access Research article

Apparent diffusion coefficient measurement by diffusion weighted magnetic resonance imaging is a useful tool in differentiating renal tumors

Jing-Hong Liu, Shi-Feng Tian, Ye Ju, Ye Li, An-Liang Chen, Li-Hua Chen, Ai-Lian Liu

Open Access Research article

Overexpression of IL-15 promotes tumor destruction via NK1.1+ cells in a spontaneous breast cancer model

Amy E Gillgrass, Marianne V Chew, Tamara Krneta, Ali A Ashkar

Open Access Research article

Body mass index and participation in organized mammographic screening: a prospective cohort study

Sophie Sell Hellmann, Sisse Helle Njor, Elsebeth Lynge, My von Euler-Chelpin, Anja Olsen, Anne Tjønneland, Ilse Vejborg, Zorana Jovanovic Andersen

Open Access Study protocol

Protocol of a multi-centre randomised controlled trial of a web-based information intervention with nurse-delivered telephone support for haematological cancer patients and their support persons

Jamie Bryant, Rob Sanson-Fisher, William Stevenson, Rochelle Smits, Frans Henskens, Andrew Wei, Flora Tzelepis, Catherine D’Este, Christine Paul, Mariko Carey

Open Access Research article

Targeting connexin 43 with α–connexin carboxyl-terminal (ACT1) peptide enhances the activity of the targeted inhibitors, tamoxifen and lapatinib, in breast cancer: clinical implication for ACT1

Christina L Grek, Joshua Matthew Rhett, Jaclynn S Bruce, Melissa A Abt, Gautam S Ghatnekar, Elizabeth S Yeh

Open Access Research article

Circulating miR-200c and miR-141 and outcomes in patients with breast cancer

Silvia Antolín, Lourdes Calvo, Moisés Blanco-Calvo, María Paz Santiago, María José Lorenzo-Patiño, Mar Haz-Conde, Isabel Santamarina, Angélica Figueroa, Luis Miguel Antón-Aparicio, Manuel Valladares-Ayerbes

Open Access Research article

Epidemiology, clinical profile and treatment patterns of venous thromboembolism in cancer patients in Taiwan: a population-based study

Tan-Wei Chew, Churn-Shiouh Gau, Yu-Wen Wen, Li-Jiuan Shen, C Daniel Mullins, Fei-Yuan Hsiao

Open Access Research article

A pilot study of bevacizumab combined with etoposide and cisplatin in breast cancer patients with leptomeningeal carcinomatosis

Pei-Fang Wu, Ching-Hung Lin, Ching-Hua Kuo, Wei-Wu Chen, Dah-Cherng Yeh, Hsiao-Wei Liao, Shu-Min Huang, Ann-Lii Cheng, Yen-Shen Lu

Open Access Research article

SNAI2/SLUG and estrogen receptor mRNA expression are inversely correlated and prognostic of patient outcome in metastatic non-small cell lung cancer

Akin Atmaca, Ralph W Wirtz, Dominique Werner, Kristina Steinmetz, Silke Claas, Wolfgang M Brueckl, Elke Jäger, Salah-Eddin Al-Batran

Open Access Research article

Cancerous inhibitor of protein phosphatase 2A (CIP2A) is an independent prognostic marker in wild-type KRAS metastatic colorectal cancer after colorectal liver metastasectomy

Kuen-Feng Chen, Chueh-Chuan Yen, Jen-Kou Lin, Wei-Shone Chen, Shung-Haur Yang, Jeng-Kai Jiang, Yuan-Tzu Lan, Chun-Chi Lin, Hui-Chuan Yu, Hui-Mei Hsu, Wen-Ling Lin, Hao-Wei Teng

Open Access Study protocol

Screening and treatment of psychological distress in patients with metastatic colorectal cancer: study protocol of the TES trial

Claudia SEW Schuurhuizen, Annemarie MJ Braamse, Aartjan TF Beekman, Hanna Bomhof-Roordink, Judith E Bosmans, Pim Cuijpers, Adriaan W Hoogendoorn, Inge RHM Konings, Mecheline HM van der Linden, Elisabeth CW Neefjes, Henk MW Verheul, Joost Dekker

Open Access Research article

Everolimus in metastatic renal cell carcinoma after failure of initial anti–VEGF therapy: final results of a noninterventional study

Lothar Bergmann, Ulrich Kube, Christian Doehn, Thomas Steiner, Peter J Goebell, Manfred Kindler, Edwin Herrmann, Jan Janssen, Steffen Weikert, Michael T Scheffler, Joerg Schmitz, Michael Albrecht, Michael Staehler

Open Access Research article

The impact of FGFR1 and FRS2α expression on sorafenib treatment in metastatic renal cell carcinoma

Thai H Ho, Xian-De Liu, Yanqing Huang, Carla L Warneke, Marcella M Johnson, Anh Hoang, Pheroze Tamboli, Fen Wang, Eric Jonasch

Open Access Research article

Is maximum primary tumor diameter still a prognostic factor in patients with nasopharyngeal carcinoma treated using intensity-modulated radiotherapy?

Yong Chen, Xue-Feng Hu, Yan Wang, Hai-Yang Chen, Lin Yang, Li-Zhi Liu, Chun-Yan Cui, Dong-Sheng Liu, Shao-Bo Liang

Open Access Research article

STAT3 is involved in miR-124-mediated suppressive effects on esophageal cancer cells

Yan Cheng, Yang Li, Yuanyuan Nian, Dong Liu, Fei Dai, Jun Zhang

Open Access Research article

Mammographic microcalcifications and breast cancer tumorigenesis: a radiologic-pathologic analysis

Madiha Naseem, Joshua Murray, John F Hilton, Jason Karamchandani, Derek Muradali, Hala Faragalla, Chanele Polenz, Dolly Han, David C Bell, Christine Brezden-Masley

Open Access Research article

Diagnostic intervals before and after implementation of cancer patient pathways – a GP survey and registry based comparison of three cohorts of cancer patients

Henry Jensen, Marie Louise Tørring, Frede Olesen, Jens Overgaard, Morten Fenger-Grøn, Peter Vedsted

Open Access Research article

A microRNA profile associated with Opisthorchis viverrini-induced cholangiocarcinoma in tissue and plasma

Jordan Plieskatt, Gabriel Rinaldi, Yanjun Feng, Jin Peng, Samantha Easley, Xinying Jia, Jeremy Potriquet, Chawalit Pairojkul, Vajarabhongsa Bhudhisawasdi, Banchob Sripa, Paul J Brindley, Jeffrey Bethony, Jason Mulvenna

Open Access Research article

Adult metanephric adenoma presumed to be all benign? A clinical perspective

Gang Li, Yuhong Tang, Renya Zhang, Hualin Song, Shumin Zhang, Yuanjie Niu

Open Access Research article

Frequency and distribution of Notch mutations in tumor cell lines

Anders Peter Mutvei, Erik Fredlund, Urban Lendahl

Open Access Study protocol

A phase II RCT and economic analysis of three exercise delivery methods in men with prostate cancer on androgen deprivation therapy

Shabbir MH Alibhai, Daniel Santa Mina, Paul Ritvo, Catherine Sabiston, Murray Krahn, George Tomlinson, Andrew Matthew, Roanne Segal, Padraig Warde, Sara Durbano, Meagan O’Neill, Nicole Culos-Reed

Open Access Research article

A model-based assessment of the cost–utility of strategies to identify Lynch syndrome in early-onset colorectal cancer patients

Tristan Snowsill, Nicola Huxley, Martin Hoyle, Tracey Jones-Hughes, Helen Coelho, Chris Cooper, Ian Frayling, Chris Hyde

Open Access Research article

Association between epidermal growth factor gene +61A/G polymorphism and the risk of hepatocellular carcinoma: a meta-analysis based on 16 studies

Guoping Jiang, Ke Yu, Lifang Shao, Xiaobo Yu, Chen Hu, Pei Qian, Haiyang Xie, Jinjun Li, Jie Zheng, Shusen Zheng

Open Access Research article

Organized breast screening improves reattendance compared to physician referral: a case control study

Ilia Makedonov, Sumei Gu, Lawrence F Paszat

Open Access Research article

Local pelvic irradiation modulates Pharmacokinetics of 5-Fluorouracil in the plasma but not in the Lymphatic System

Chen-Hsi Hsieh, Mei-Ling Hou, Li-Ying Wang, Hung-Chi Tai, Tung-Hu Tsai, Yu-Jen Chen

Open Access Research article

Therapeutic effect of intravesical administration of paclitaxel solubilized with poly(2-methacryloyloxyethyl phosphorylcholine-co-n-butyl methacrylate) in an orthotopic bladder cancer model

Koetsu Tamura, Eiji Kikuchi, Tomohiro Konno, Kazuhiko Ishihara, Kazuhiro Matsumoto, Akira Miyajima, Mototsugu Oya

Open Access Research article

Management and prognosis of patients with brain metastasis from gestational trophoblastic neoplasia: a 24-year experience in Peking union medical college hospital

Changji Xiao, Junjun Yang, Jing Zhao, Tong Ren, Fengzhi Feng, Xirun Wan, Yang Xiang

Open Access Research Article

Identification of sample-specific regulations using integrative network level analysis

Chengyu Liu, Riku Louhimo, Marko Laakso, Rainer Lehtonen, Sampsa Hautaniemi

Open Access Research article

Targeted next generation sequencing of RB1 gene for the molecular diagnosis of Retinoblastoma

Bharanidharan Devarajan, Logambiga Prakash, Thirumalai Raj Kannan, Aloysius A Abraham, Usha Kim, Veerappan Muthukkaruppan, Ayyasamy Vanniarajan

Open Access Study protocol

Internet-based cognitive behavioral therapy for sexual dysfunctions in women treated for breast cancer: design of a multicenter, randomized controlled trial

Susanna B Hummel, Jacques JDM van Lankveld, Hester SA Oldenburg, Daniela EE Hahn, Eva Broomans, Neil K Aaronson

Open Access Research article

Neoadjuvant chemoradiation therapy for resectable esophago-gastric adenocarcinoma: a meta-analysis of randomized clinical trials

Tao Fu, Zhao-De Bu, Zi-Yu Li, Lian-Hai Zhang, Xiao-Jiang Wu, Ai-Wen Wu, Fei Shan, Xin Ji, Qiu-Shi Dong, Jia-Fu Ji

Open Access Research article

Correlation of Aurora-A expression with the effect of chemoradiation therapy on esophageal squamous cell carcinoma

Kiyokazu Tamotsu, Hiroshi Okumura, Yasuto Uchikado, Yoshiaki Kita, Ken Sasaki, Itaru Omoto, Tetsuhiro Owaki, Takaaki Arigami, Yoshikazu Uenosono, Akihiro Nakajo, Yuko Kijima, Sumiya Ishigami, Shoji Natsugoe

Open Access Research article

Down-regulation of NF kappa B activation is an effective therapeutic modality in acquired platinum-resistant bladder cancer

Yujiro Ito, Eiji Kikuchi, Nobuyuki Tanaka, Takeo Kosaka, Eriko Suzuki, Ryuichi Mizuno, Toshiaki Shinojima, Akira Miyajima, Kazuo Umezawa, Mototsugu Oya

Open Access Research article

DNA Polymerases as targets for gene therapy of hepatocellular carcinoma

Hao Liu, Qun Wei, Jia Wang, Xiaoming Huang, Chunchun Li, Qiaoli Zheng, Jiang Cao, Zhenyu Jia

Open Access Research article

PKCα promotes the mesenchymal to amoeboid transition and increases cancer cell invasiveness

Katarína Vaškovičová, Emilia Szabadosová, Vladimír Čermák, Aneta Gandalovičová, Lenka Kasalová, Daniel Rösel, Jan Brábek

Open Access Research article

Capecitabine and irinotecan with bevacizumab 2-weekly for metastatic colorectal cancer: the phase II AVAXIRI study

Pilar Garcia-Alfonso, Manuel Chaves, Andrés Muñoz, Antonieta Salud, Maria García-Gonzalez, Cristina Grávalos, Bartomeu Massuti, Encarna González-Flores, Bernardo Queralt, Amelia López-Ladrón, Ferran Losa, Maria Jose Gómez, Amparo Oltra, Enrique Aranda

Open Access Research article

Circulating miRNAs miR-34a and miR-150 associated with colorectal cancer progression

Sinéad T Aherne, Stephen F Madden, David J Hughes, Barbara Pardini, Alessio Naccarati, Miroslav Levy, Pavel Vodicka, Paul Neary, Paul Dowling, Martin Clynes

Open Access Research article

Retrospective evaluation of the incidental finding of 403 papillary thyroid microcarcinomas in 2466 patients undergoing thyroid surgery for presumed benign thyroid disease

Nikola Slijepcevic, Vladan Zivaljevic, Jelena Marinkovic, Sandra Sipetic, Aleksandar Diklic, Ivan Paunovic

Open Access Research article

Effects of JWA, XRCC1 and BRCA1 mRNA expression on molecular staging for personalized therapy in patients with advanced esophageal squamous cell carcinoma

Bin Wei, Qin Han, Lijuan Xu, Xiaohui Zhang, Jing Zhu, Li Wan, Yan Jin, Zhaoye Qian, Jingjing Wu, Yong Gao, Jianwei Zhou, Xiaofei Chen

Open Access Research article

High expression of Talin-1 is associated with poor prognosis in patients with nasopharyngeal carcinoma

Ya-Fei Xu, Xian-Yue Ren, Ying-Qin Li, Qing-Mei He, Xin-Ran Tang, Ying Sun, Jian-Yong Shao, Wei-Hua Jia, Tie-Bang Kang, Mu-Sheng Zeng, Na Liu, Jun Ma

Open Access Research article

FGF9 from cancer-associated fibroblasts is a possible mediator of invasion and anti-apoptosis of gastric cancer cells

Chao Sun, Hirokazu Fukui, Ken Hara, Xinxing Zhang, Yoshitaka Kitayama, Hirotsugu Eda, Toshihiko Tomita, Tadayuki Oshima, Shojiro Kikuchi, Jiro Watari, Mitsuru Sasako, Hiroto Miwa

Open Access Research article

Systematic review of model-based cervical screening evaluations

Diana Mendes, Iren Bains, Tazio Vanni, Mark Jit

Open Access Research article

Transient elevation of glycolysis confers radio-resistance by facilitating DNA repair in cells

Anant Narayan Bhatt, Ankit Chauhan, Suchit Khanna, Yogesh Rai, Saurabh Singh, Ravi Soni, Namita Kalra, Bilikere S Dwarakanath

Open Access Research article

Determinants of gastric cancer screening attendance in Korea: a multi-level analysis

Yunryong Chang, Belong Cho, Ki Young Son, Dong Wook Shin, Hosung Shin, Hyung-Kook Yang, Aesun Shin, Keun-Young Yoo

Open Access Research article

Transcriptional implications of intragenic DNA methylation in the oestrogen receptor alpha gene in breast cancer cells and tissues

Natalie S Shenker, Kirsty J Flower, Charlotte S Wilhelm-Benartzi, Wei Dai, Emma Bell, Edmund Gore, Mona El Bahrawy, Gillian Weaver, Robert Brown, James M Flanagan

Open Access Research article

Nomogram for overall survival of Japanese patients with bone-metastatic prostate cancer

Yasuhide Miyoshi, Kazumi Noguchi, Masahiro Yanagisawa, Masataka Taguri, Satoshi Morita, Ichiro Ikeda, Kiyoshi Fujinami, Takeshi Miura, Kazuki Kobayashi, Hiroji Uemura

Open Access Research article

Phase II study of axitinib with doublet chemotherapy in patients with advanced squamous non–small-cell lung cancer

Igor M Bondarenko, Antonella Ingrosso, Paul Bycott, Sinil Kim, Cristina L Cebotaru

Open Access Research article

Colorectal carcinomas with KRAS codon 12 mutation are associated with more advanced tumor stages

Wenbin Li, Tian Qiu, Wenxue Zhi, Susheng Shi, Shuangmei Zou, Yun Ling, Ling Shan, Jianming Ying, Ning Lu

Open Access Research article

Early diagnostic value of Bcl-3 localization in colorectal cancer

Karunakar Saamarthy, Sofie Björner, Martin Johansson, Göran Landberg, Ramin Massoumi, Karin Jirström, Katarzyna Chmielarska Masoumi

Open Access Research article

Wilms’ tumor gene 1 regulates p63 and promotes cell proliferation in squamous cell carcinoma of the head and neck

Xingru Li, Sofia Ottosson, Sihan Wang, Emma Jernberg, Linda Boldrup, Xiaolian Gu, Karin Nylander, Aihong Li

Open Access Research article

MTA2 enhances colony formation and tumor growth of gastric cancer cells through IL-11

Chenfei Zhou, Jun Ji, Qu Cai, Min Shi, Xuehua Chen, Yingyan Yu, Zhenggang Zhu, Jun Zhang

Open Access Research article

Risk factors and clinical outcomes of acute myeloid leukaemia with central nervous system involvement in adults

Chieh-Lung Cheng, Chi-Cheng Li, Hsin-An Hou, Wei-Quan Fang, Chin-Hao Chang, Chien-Ting Lin, Jih-Luh Tang, Wen-Chien Chou, Chien-Yuan Chen, Ming Yao, Shang-Yi Huang, Bor-Sheng Ko, Shang-Ju Wu, Woei Tsay, Hwei-Fang Tien

Open Access Research article

MicroRNA-10a is reduced in breast cancer and regulated in part through retinoic acid

Sonja Khan, Deirdre Wall, Catherine Curran, John Newell, Michael J Kerin, Roisin M Dwyer

Open Access Research article

Nonsense and missense mutation of mitochondrial ND6 gene promotes cell migration and invasion in human lung adenocarcinoma

Yang Yuan, Weixing Wang, Huizhong Li, Yongwei Yu, Jin Tao, Shengdong Huang, Zhiyong Zeng

Open Access Research article

The pretreatment albumin to globulin ratio predicts chemotherapeutic outcomes in patients with unresectable metastatic colorectal cancer

Masatsune Shibutani, Kiyoshi Maeda, Hisashi Nagahara, Hiroshi Ohtani, Yasuhito Iseki, Tetsuro Ikeya, Kenji Sugano, Kosei Hirakawa

Open Access Research article

The emerging outcome of postoperative radiotherapy for stage IIIA(N2) non-small cell lung cancer patients: based on the three-dimensional conformal radiotherapy technique and institutional standard clinical target volume

Wen Feng, Qin Zhang, Xiao-Long Fu, Xu-Wei Cai, Zheng-Fei Zhu, Huan-Jun Yang, Jia-Qing Xiang, Ya-Wei Zhang, Hai-Quan Chen

Open Access Research article

Clusterin transcript variants expression in thyroid tumor: a potential marker of malignancy?

Paolo Fuzio, Anna Napoli, Anna Ciampolillo, Serafina Lattarulo, Angela Pezzolla, Nicoletta Nuzziello, Sabino Liuni, Francesco Giorgino, Eugenio Maiorano, Elda Perlino

Open Access Research article

A novel inflammation-based prognostic score in esophageal squamous cell carcinoma: the C-reactive protein/albumin ratio

Xiao-li Wei, Feng-hua Wang, Dong-sheng Zhang, Miao-zhen Qiu, Chao Ren, Ying Jin, Yi-xin Zhou, De-shen Wang, Ming-ming He, Long Bai, Feng Wang, Hui-yan Luo, Yu-hong Li, Rui-hua Xu

Open Access Technical advance

Cytotoxicity and infiltration of human NK cells in in vivo-like tumor spheroids

Ariane Giannattasio, Sandra Weil, Stephan Kloess, Nariman Ansari, Ernst H K Stelzer, Adelheid Cerwenka, Alexander Steinle, Ulrike Koehl, Joachim Koch

Open Access Research article

Proteoglycan-based diversification of disease outcome in head and neck cancer patients identifies NG2/CSPG4 and syndecan-2 as unique relapse and overall survival predicting factors

Anna Farnedi, Silvia Rossi, Nicoletta Bertani, Mariolina Gulli, Enrico Maria Silini, Maria Teresa Mucignat, Tito Poli, Enrico Sesenna, Davide Lanfranco, Lucio Montebugnoli, Elisa Leonardi, Claudio Marchetti, Renato Cocchi, Andrea Ambrosini-Spaltro, Maria Pia Foschini, Roberto Perris

Open Access Research article

Randomized phase III trial of radiotherapy or chemoradiotherapy with topotecan and cisplatin in intermediate-risk cervical cancer patients after radical hysterectomy

Wenze Sun, Tao Wang, Fan Shi, Jiquan Wang, Juan Wang, Beina Hui, Yingbing Zhang, Jinli Lu, Hongwei Chen, Zi Liu

Open Access Research article

Healthcare costs attributable to the treatment of patients with spinal metastases: a cohort study with up to 8 years follow-up

Line Stjernholm Tipsmark, Cody Eric Bünger, Miao Wang, Søren Schmidt Morgen, Benny Dahl, Rikke Søgaard

Open Access Study protocol

Efficacy of laparoscopic subtotal gastrectomy with D2 lymphadenectomy for locally advanced gastric cancer: the protocol of the KLASS-02 multicenter randomized controlled clinical trial

Hoon Hur, Hyun Yong Lee, Hyuk-Joon Lee, Min Chan Kim, Woo Jin Hyung, Young Kyu Park, Wook Kim, Sang-Uk Han

Open Access Research article

Inhibition of colony stimulating factor-1 receptor improves antitumor efficacy of BRAF inhibition

Stephen Mok, Jennifer Tsoi, Richard C Koya, Siwen Hu-Lieskovan, Brian L West, Gideon Bollag, Thomas G Graeber, Antoni Ribas

Open Access Research article

ZFP36 stabilizes RIP1 via degradation of XIAP and cIAP2 thereby promoting ripoptosome assembly

Tommaso Selmi, Claudia Alecci, Miriam dell’ Aquila, Lucia Montorsi, Andrea Martello, Filippo Guizzetti, Nicola Volpi, Sandra Parenti, Sergio Ferrari, Paolo Salomoni, Alexis Grande, Tommaso Zanocco-Marani

Open Access Research article

Mechanism study of peptide GMBP1 and its receptor GRP78 in modulating gastric cancer MDR by iTRAQ-based proteomic analysis

Xiaojuan Wang, Yani Li, Guanghui Xu, Muhan Liu, Lin Xue, Lijuan Liu, Sijun Hu, Ying Zhang, Yongzhan Nie, Shuhui Liang, Biaoluo Wang, Jie Ding

Open Access Research article

Metronomic oral vinorelbine as first-line treatment in elderly patients with advanced non-small cell lung cancer: results of a phase II trial (MOVE trial)

Andrea Camerini, Cheti Puccetti, Sara Donati, Chiara Valsuani, Maria Cristina Petrella, Gianna Tartarelli, Paolo Puccinelli, Domenico Amoroso

Open Access Technical advance

High-recovery visual identification and single-cell retrieval of circulating tumor cells for genomic analysis using a dual-technology platform integrated with automated immunofluorescence staining

Daniel E Campton, Arturo B Ramirez, Joshua J Nordberg, Nick Drovetto, Alisa C Clein, Paulina Varshavskaya, Barry H Friemel, Steve Quarre, Amy Breman, Michael Dorschner, Sibel Blau, C Anthony Blau, Daniel E Sabath, Jackie L Stilwell, Eric P Kaldjian

Open Access Research article

Chromosomal instability as a prognostic marker in cervical cancer

Christine How, Jeff Bruce, Jonathan So, Melania Pintilie, Benjamin Haibe-Kains, Angela Hui, Blaise A Clarke, David W Hedley, Richard P Hill, Michael Milosevic, Anthony Fyles, Fei-Fei Liu

Open Access Research article

HBx induced AFP receptor expressed to activate PI3K/AKT signal to promote expression of Src in liver cells and hepatoma cells

Mingyue Zhu, Junli Guo, Wei Li, Hua Xia, Yan Lu, Xu Dong, Yi Chen, Xieju Xie, Shigan Fu, Mengsen Li

Open Access Research article

Prognostic model for long-term survival of locally advanced non-small-cell lung cancer patients after neoadjuvant radiochemotherapy and resection integrating clinical and histopathologic factors

Christoph Pöttgen, Martin Stuschke, Britta Graupner, Dirk Theegarten, Thomas Gauler, Verena Jendrossek, Lutz Freitag, Jehad Abu Jawad, Eleni Gkika, Jeremias Wohlschlaeger, Stefan Welter, Matthias Hoiczyk, Martin Schuler, Georgios Stamatis, Wilfried Eberhardt

Open Access Research article

Utility of SAM68 in the progression and prognosis for bladder cancer

Zhiling Zhang, Chunping Yu, Yonghong Li, Lijuan Jiang, Fangjian Zhou

Open Access Study protocol

Treatment strategies in colorectal cancer patients with initially unresectable liver-only metastases, a study protocol of the randomised phase 3 CAIRO5 study of the Dutch Colorectal Cancer Group (DCCG)

Joost Huiskens, Thomas M van Gulik, Krijn P van Lienden, Marc RW Engelbrecht, Gerrit A Meijer, Nicole CT van Grieken, Jonne Schriek, Astrid Keijser, Linda Mol, I Quintus Molenaar, Cornelis Verhoef, Koert P de Jong, Kees HC Dejong, Geert Kazemier, Theo M Ruers, Johanus HW de Wilt, Harm van Tinteren, Cornelis JA Punt

Open Access Research article

The prevention, detection and management of cancer treatment-induced cardiotoxicity: a meta-review

Aaron Conway, Alexandra L McCarthy, Petra Lawrence, Robyn A Clark

Open Access Research article

Plasma membrane proteomic analysis of human Gastric Cancer tissues: revealing flotillin 1 as a marker for Gastric Cancer

Wen Gao, Jing Xu, Fuqiang Wang, Long Zhang, Rui Peng, Yongqian Shu, Jindao Wu, Qiyun Tang, Yunxia Zhu

Open Access Research article

URG4/URGCP enhances the angiogenic capacity of human hepatocellular carcinoma cells in vitro via activation of the NF-κB signaling pathway

Sizhong Xing, Bing Zhang, Ruixi Hua, William Chi-shing Tai, Zhirong Zeng, Binhui Xie, Chenghui Huang, Jisu Xue, Shiqiu Xiong, Jianyong Yang, Side Liu, Heping Li

Open Access Research article

The prognostic significance of lymphovascular invasion in patients with resectable gastric cancer: a large retrospective study from Southern China

Peng Li, Hao-Qiang He, Chong-Mei Zhu, Yi-Hong Ling, Wan-Ming Hu, Xin-Ke Zhang, Rong-Zhen Luo, Jing-Ping Yun, Dan Xie, Yuan-Fang Li, Mu-Yan Cai

Open Access Research article

Soluble EpCAM levels in ascites correlate with positive cytology and neutralize catumaxomab activity in vitro

Andreas Seeber, Agnieszka Martowicz, Gilbert Spizzo, Thomas Buratti, Peter Obrist, Dominic Fong, Guenther Gastl, Gerold Untergasser

Open Access Research article

Reducing tumor growth and angiogenesis using a triple therapy measured with Contrast-enhanced ultrasound (CEUS)

Philipp Marius Paprottka, Svenja Roßpunt, Michael Ingrisch, Clemens C Cyran, Konstantin Nikolaou, Maximilian F Reiser, Brigitte Mack, Olivier Gires, Dirk A Clevert, Pamela Zengel

Open Access Research article

The combination of sorafenib and everolimus shows antitumor activity in preclinical models of malignant pleural mesothelioma

Ymera Pignochino, Carmine Dell’Aglio, Simona Inghilleri, Michele Zorzetto, Marco Basiricò, Federica Capozzi, Marta Canta, Davide Piloni, Francesca Cemmi, Dario Sangiolo, Loretta Gammaitoni, Marco Soster, Serena Marchiò, Ernesto Pozzi, Patrizia Morbini, Maurizio Luisetti, Massimo Aglietta, Giovanni Grignani, Giulia M Stella

Open Access Research article

Mesothelioma patient derived tumor xenografts with defined BAP1 mutations that mimic the molecular characteristics of human malignant mesothelioma

Neetu Kalra, Jingli Zhang, Anish Thomas, Liqiang Xi, Mitchell Cheung, Jacqueline Talarchek, Sandra Burkett, Maria G Tsokos, Yuanbin Chen, Mark Raffeld, Markku Miettinen, Ira Pastan, Joseph R Testa, Raffit Hassan

Open Access Research article

The prognostic value of EGFR overexpression and amplification in Esophageal squamous cell Carcinoma

Dongxian Jiang, Xiaojing Li, Haixing Wang, Yuan Shi, Chen Xu, Shaohua Lu, Jie Huang, Yifan Xu, Haiying Zeng, Jieakesu Su, Yingyong Hou, Lijie Tan

Open Access Research article

Feasibility of a multimodal 18F-FDG-directed lymph node surgical excisional biopsy approach for appropriate diagnostic tissue sampling in patients with suspected lymphoma

Stephen P Povoski, Nathan C Hall, Douglas A Murrey Jr, Chadwick L Wright, Edward W Martin Jr

Open Access Research article

Prognostic value of tumor suppressors in osteosarcoma before and after neoadjuvant chemotherapy

Bernhard Robl, Chantal Pauli, Sander Martijn Botter, Beata Bode-Lesniewska, Bruno Fuchs

Open Access Research article

High expression of KPNA2 defines poor prognosis in patients with upper tract urothelial carcinoma treated with radical nephroureterectomy

Bentao Shi, Boxing Su, Dong Fang, Yuan Tang, Gengyan Xiong, Zhongqiang Guo, Qun He, Xinyu Yang, Wei Zhao, Yinglu Guo, Xuesong Li, Liqun Zhou

Open Access Research article

Significance of KRAS/PAK1/Crk pathway in non-small cell lung cancer oncogenesis

Fariborz Mortazavi, Jie Lu, Ryan Phan, Michael Lewis, Kenny Trinidad, Amir Aljilani, Gholamhossein Pezeshkpour, Fuyuhiko Tamanoi

Open Access Research article

Improved false negative rate of axillary status using sentinel lymph node biopsy and ultrasound-suspicious lymph node sampling in patients with early breast cancer

Yulong Wang, Haiyan Dong, Hongyan Wu, Li Zhang, Kai Yuan, Hongqiang Chen, Mingwen Jiao, Rongzhan Fu

Open Access Research article

Genome-wide association study of susceptibility loci for breast cancer in Sardinian population

Grazia Palomba, Angela Loi, Eleonora Porcu, Antonio Cossu, Ilenia Zara, Mario Budroni, Mariano Dei, Sandra Lai, Antonella Mulas, Nina Olmeo, Maria Teresa Ionta, Francesco Atzori, Gianmauro Cuccuru, Maristella Pitzalis, Magdalena Zoledziewska, Nazario Olla, Mario Lovicu, Marina Pisano, Gonçalo R. Abecasis, Manuela Uda, Francesco Tanda, Kyriaki Michailidou, Douglas F. Easton, Stephen J. Chanock, Robert N. Hoover, David J. Hunter, David Schlessinger, Serena Sanna, Laura Crisponi, Giuseppe Palmieri

Open Access Research article

Randomized phase III clinical trial comparing the combination of capecitabine and oxaliplatin (CAPOX) with the combination of 5-fluorouracil, leucovorin and oxaliplatin (modified FOLFOX6) as adjuvant therapy in patients with operated high-risk stage II or stage III colorectal cancer

Dimitrios Pectasides, Vasilios Karavasilis, George Papaxoinis, Georgia Gourgioti, Thomas Makatsoris, Georgia Raptou, Eleni Vrettou, Joseph Sgouros, Epaminontas Samantas, George Basdanis, Pavlos Papakostas, Dimitrios Bafaloukos, Vassiliki Kotoula, Haralambos P. Kalofonos, Chrisoula D. Scopa, George Pentheroudakis, George Fountzilas

Open Access Research article

Dysregulated cholinergic network as a novel biomarker of poor prognostic in patients with head and neck squamous cell carcinoma

Ana Cristina Castillo-González, Susana Nieto-Cerón, Juan Pablo Pelegrín-Hernández, María Fernanda Montenegro, José Antonio Noguera, María Fuensanta López-Moreno, José Neptuno Rodríguez-López, Cecilio J Vidal, Diego Hellín-Meseguer, Juan Cabezas-Herrera

Open Access Technical advance

Optimisation of immunofluorescence methods to determine MCT1 and MCT4 expression in circulating tumour cells

Stephen Kershaw, Jeffrey Cummings, Karen Morris, Jonathan Tugwood, Caroline Dive

Open Access Research article

Hospital discharges for fever and neutropenia in pediatric cancer patients: United States, 2009

Emily L. Mueller, Kelly J. Walkovich, Rajen Mody, Achamyeleh Gebremariam, Matthew M. Davis

Open Access Research article

The role of c-Src in the invasion and metastasis of hepatocellular carcinoma cells induced by association of cell surface GRP78 with activated α2M

Song Zhao, Hongdan Li, Qingjun Wang, Chang Su, Guan Wang, Huijuan Song, Liang Zhao, Zhidong Luan, Rongjian Su

Open Access Research article

Mitogen- and stress-activated Kinase 1 mediates Epstein-Barr virus latent membrane protein 1-promoted cell transformation in nasopharyngeal carcinoma through its induction of Fra-1 and c-Jun genes

Binbin Li, Zheng Wan, Guoliang Huang, Zunnan Huang, Xiangning Zhang, Dan Liao, Shengqun Luo, Zhiwei He

Open Access Research article

NBPF1, a tumor suppressor candidate in neuroblastoma, exerts growth inhibitory effects by inducing a G1 cell cycle arrest

Vanessa Andries, Karl Vandepoele, Katrien Staes, Geert Berx, Pieter Bogaert, Gert Van Isterdael, Daisy Ginneberge, Eef Parthoens, Jonathan Vandenbussche, Kris Gevaert, Frans van Roy

Open Access Research article

Impact of neo-adjuvant Sorafenib treatment on liver transplantation in HCC patients - a prospective, randomized, double-blind, phase III trial

Katrin Hoffmann, Tom Ganten, Daniel Gotthardtp, Boris Radeleff, Utz Settmacher, Otto Kollmar, Silvio Nadalin, Irini Karapanagiotou-Schenkel, Christof von Kalle, Dirk Jäger, Markus W Büchler, Peter Schemmer

Open Access Research article

Increased risk of second primary malignancies following uterine cancer: a population-based study in Taiwan over a 30-year period

Kuan-Der Lee, Chao-Yu Chen, Huei-Jean Huang, Ting-Yao Wang, David Teng, Shih-Hao Huang, Chyong-Huey Lai, Min-Chi Chen

Open Access Study protocol

The patient-breast cancer care pathway: how could it be optimized?

Sandrine Baffert, Huong Ly Hoang, Anne Brédart, Bernard Asselain, Séverine Alran, Hélène Berseneff, Cyrille Huchon, Caroline Trichot, Aline Combes, Karine Alves, Martin Koskas, Thuy Nguyen, Aurélie Roulot, Roman Rouzier, Delphine Héquet

Open Access Research article

Phase I/II study of temsirolimus for patients with unresectable Hepatocellular Carcinoma (HCC)- a correlative study to explore potential biomarkers for response

Winnie Yeo, Stephen L Chan, Frankie KF Mo, Cheuk M Chu, Joyce WY Hui, Joanne HM Tong, Anthony WH Chan, Jane Koh, Edwin P Hui, Herbert Loong, Kirsty Lee, Leung Li, Brigette Ma, Ka F To, Simon CH Yu

Open Access Research article

Preoperative serum CA125: a useful marker for surgical management of endometrial cancer

Tao Jiang, Ling Huang, Shulan Zhang

Open Access Case report

A male patient with acromegaly and breast cancer: treating acromegaly to control tumor progression

Paola Leporati, Rodolfo Fonte, Luca de Martinis, Alberto Zambelli, Flavia Magri, Lorenzo Pavesi, Mario Rotondi, Luca Chiovato

Open Access Research article

Hyperemesis gravidarum and risk of cancer in offspring, a Scandinavian registry-based nested case–control study

Kathrine F. Vandraas, Åse V. Vikanes, Nathalie C. Støer, Rebecca Troisi, Olof Stephansson, Henrik T. Sørensen, Siri Vangen, Per Magnus, Andrej M. Grjibovski, Tom Grotmol

Open Access Research article

Variable expression levels of keratin and vimentin reveal differential EMT status of circulating tumor cells and correlation with clinical characteristics and outcome of patients with metastatic breast cancer

Hara Polioudaki, Sofia Agelaki, Rena Chiotaki, Eleni Politaki, Dimitris Mavroudis, Alexios Matikas, Vassilis Georgoulias, Panayiotis A Theodoropoulos

Open Access Case report

Prolonged survival of a patient with metastatic leptomeningeal melanoma treated with BRAF inhibition-based therapy: a case report

Dae Won Kim, Edelyn Barcena, Urvi N Mehta, Michelle L Rohlfs, Ashok J Kumar, Marta Penas-Prado, Kevin B Kim

Open Access Research article

Mitochondrially targeted vitamin E succinate efficiently kills breast tumour-initiating cells in a complex II-dependent manner

Bing Yan, Marina Stantic, Renata Zobalova, Ayenachew Bezawork-Geleta, Michael Stapelberg, Jan Stursa, Katerina Prokopova, Lanfeng Dong, Jiri Neuzil

Open Access Research article

The impact of HER2 phenotype of circulating tumor cells in metastatic breast cancer: a retrospective study in 107 patients

Markus Wallwiener, Andreas Daniel Hartkopf, Sabine Riethdorf, Juliane Nees, Martin Ronald Sprick, Birgitt Schönfisch, Florin-Andrei Taran, Jörg Heil, Christof Sohn, Klaus Pantel, Andreas Trumpp, Andreas Schneeweiss

Open Access Research article

Identification of novel drugs to target dormant micrometastases

Robert E. Hurst, Paul J. Hauser, Youngjae You, Lora C. Bailey-Downs, Anja Bastian, Stephen M. Matthews, Jessica Thorpe, Christine Earle, Lilly Y. W. Bourguignon, Michael A. Ihnat

Open Access Research article

Opportunistic mammography screening provides effective detection rates in a limited resource healthcare system

Yew-Ching Teh, Gie-Hooi Tan, Nur Aishah Taib, Kartini Rahmat, Caroline Judy Westerhout, Farhana Fadzli, Mee-Hoong See, Suniza Jamaris, Cheng-Har Yip

Open Access Research article

Clinical characteristics of narrow-band imaging of oral erythroplakia and its correlation with pathology

Shih-Wei Yang, Yun-Shien Lee, Liang-Che Chang, Cheng-Cheng Hwang, Cheng-Ming Luo, Tai-An Chen

Open Access Research article

Autoantibodies in breast cancer sera are not epiphenomena and may participate in carcinogenesis

Félix Fernández Madrid, Marie-Claire Maroun, Ofelia A Olivero, Michael Long, Azadeh Stark, Lawrence I Grossman, Walter Binder, Jingsheng Dong, Matthew Burke, S David Nathanson, Richard Zarbo, Dhananjay Chitale, Rocío Zeballos-Chávez, Carol Peebles

Open Access Research article

Early detection of breast cancer using total biochemical analysis of peripheral blood components: a preliminary study

Udi Zelig, Eyal Barlev, Omri Bar, Itai Gross, Felix Flomen, Shaul Mordechai, Joseph Kapelushnik, Ilana Nathan, Hanoch Kashtan, Nir Wasserberg, Osnat Madhala-Givon

Open Access Research article

Fractal analysis of nuclear histology integrates tumor and stromal features into a single prognostic factor of the oral cancer microenvironment

Pinaki Bose, Nigel T Brockton, Kelly Guggisberg, Steven C Nakoneshny, Elizabeth Kornaga, Alexander C Klimowicz, Mauro Tambasco, Joseph C Dort

Open Access Research article

Radiographers supporting radiologists in the interpretation of screening mammography: a viable strategy to meet the shortage in the number of radiologists

Gabriela Torres-Mejía, Robert A. Smith, María de la Luz Carranza-Flores, Andy Bogart, Louis Martínez-Matsushita, Diana L. Miglioretti, Karla Kerlikowske, Carolina Ortega-Olvera, Ernesto Montemayor-Varela, Angélica Angeles-Llerenas, Sergio Bautista-Arredondo, Gilberto Sánchez-González, Olga G. Martínez-Montañez, Santos R. Uscanga-Sánchez, Eduardo Lazcano-Ponce, Mauricio Hernández-Ávila

Open Access Research article

The glutamate transport inhibitor DL-Threo-β-Benzyloxyaspartic acid (DL-TBOA) differentially affects SN38- and oxaliplatin-induced death of drug-resistant colorectal cancer cells

Elena Pedraz-Cuesta, Sandra Christensen, Anders A. Jensen, Niels Frank Jensen, Lennart Bunch, Maria Unni Romer, Nils Brünner, Jan Stenvang, Stine Falsig Pedersen

Open Access Research article

The loss in expectation of life after colon cancer: a population-based study

Therese M-L Andersson, Paul W. Dickman, Sandra Eloranta, Annika Sjövall, Mats Lambe, Paul C. Lambert

Open Access Research article

Oncology patients overwhelmingly support tissue banking

Jamie Bryant, Rob Sanson-Fisher, Elizabeth Fradgley, Timothy Regan, Breanne Hobden, Stephen P. Ackland

Open Access Research article

Targeted deep sequencing of mucinous ovarian tumors reveals multiple overlapping RAS-pathway activating mutations in borderline and cancerous neoplasms

Robertson Mackenzie, Stefan Kommoss, Boris J. Winterhoff, Benjamin R. Kipp, Joaquin J. Garcia, Jesse Voss, Kevin Halling, Anthony Karnezis, Janine Senz, Winnie Yang, Elena-Sophie Prigge, Miriam Reuschenbach, Magnus Von Knebel Doeberitz, Blake C. Gilks, David G. Huntsman, Jamie Bakkum-Gamez, Jessica N. McAlpine, Michael S. Anglesio

Open Access Study protocol

Self-management support intervention to control cancer pain in the outpatient setting: a randomized controlled trial study protocol

Laura MJ Hochstenbach, Annemie M Courtens, Sandra MG Zwakhalen, Maarten van Kleef, Luc P de Witte

Open Access Research article

A seven-gene CpG-island methylation panel predicts breast cancer progression

Yan Li, Anatoliy A. Melnikov, Victor Levenson, Emanuela Guerra, Pasquale Simeone, Saverio Alberti, Youping Deng

Open Access Research article

Concordance analysis of methylation biomarkers detection in self-collected and physician-collected samples in cervical neoplasm

Cheng-Chang Chang, Rui-Lan Huang, Yu-Ping Liao, Po-Hsuan Su, Yaw-Wen Hsu, Hui-Chen Wang, Chau-Yang Tien, Mu-Hsien Yu, Ya-Wen Lin, Hung-Cheng Lai

Open Access Research article

Benefit of adjuvant chemotherapy in patients with T4 UICC II colon cancer

Andreas Teufel, Michael Gerken, Janine Hartl, Timo Itzel, Stefan Fichtner-Feigl, Christian Stroszczynski, Hans Jürgen Schlitt, Ferdinand Hofstädter, Monika Klinkhammer-Schalke

Open Access Research article

Risk factors of PSA progression and overall survival in patients with localized and locally advanced prostate cancer treated with primary androgen deprivation therapy

Atsushi Tomioka, Nobumichi Tanaka, Motokiyo Yoshikawa, Makito Miyake, Satoshi Anai, Yoshitomo Chihara, Eijiro Okajima, Akihide Hirayama, Yoshihiko Hirao, Kiyohide Fujimoto

Open Access Research article

The Danish cancer pathway for patients with serious non-specific symptoms and signs of cancer–a cross-sectional study of patient characteristics and cancer probability

Mads Lind Ingeman, Morten Bondo Christensen, Flemming Bro, Søren T. Knudsen, Peter Vedsted

Open Access Research article

Enhancement of hypoxia-activated prodrug TH-302 anti-tumor activity by Chk1 inhibition

Fanying Meng, Deepthi Bhupathi, Jessica D Sun, Qian Liu, Dharmendra Ahluwalia, Yan Wang, Mark D Matteucci, Charles P Hart

Open Access Research article

How do we estimate survival? External validation of a tool for survival estimation in patients with metastatic bone disease—decision analysis and comparison of three international patient populations

Andrea Piccioli, M. Silvia Spinelli, Jonathan A. Forsberg, Rikard Wedin, John H. Healey, Vincenzo Ippolito, Primo Andrea Daolio, Pietro Ruggieri, Giulio Maccauro, Alessandro Gasbarrini, Roberto Biagini, Raimondo Piana, Flavio Fazioli, Alessandro Luzzati, Alberto Di Martino, Francesco Nicolosi, Francesco Camnasio, Michele Attilio Rosa, Domenico Andrea Campanacci, Vincenzo Denaro, Rodolfo Capanna

Open Access Research article

Iron-free and iron-saturated bovine lactoferrin inhibit survivin expression and differentially modulate apoptosis in breast cancer

Jessica A. Gibbons, Jagat R. Kanwar, Rupinder K. Kanwar

Open Access Case report

A case of metastatic renal cell carcinoma and bile duct carcinoma treated with a combination of sunitinib and gemcitabine

Kotoe Takayoshi, Kosuke Sagara, Keita Uchino, Hitoshi Kusaba, Naotaka Sakamoto, Atsushi Iguchi, Eishi Baba

Open Access Research article

Tumor-induced loss of mural Connexin 43 gap junction activity promotes endothelial proliferation

Mayur Choudhary, Christine Naczki, Wenhong Chen, Keith D. Barlow, L. Douglas Case, Linda J. Metheny-Barlow

Open Access Study protocol

Adjuvant hyperthermic intraperitoneal chemotherapy (HIPEC) in patients with colon cancer at high risk of peritoneal carcinomatosis; the COLOPEC randomized multicentre trial

Charlotte E L Klaver, Gijsbert D Musters, Willem A Bemelman, Cornelis J A Punt, Victor J Verwaal, Marcel GW Dijkgraaf, Arend GJ Aalbers, Jarmila DW van der Bilt, Djamila Boerma, Andre JA Bremers, Jacobus WA Burger, Christianne J Buskens, Pauline Evers, Robert J van Ginkel, Wilhelmina MU van Grevenstein, Patrick HJ Hemmer, Ignace HJT de Hingh, Laureen A Lammers, Barbara L van Leeuwen, Wilhelmus JHJ Meijerink, Simon W Nienhuijs, Jolien Pon, Sandra A Radema, Bert van Ramshorst, Petur Snaebjornsson, Jurriaan B Tuynman, Elisabeth A te Velde, Marinus J Wiezer, Johannes HW de Wilt, Pieter J Tanis

Open Access Research article

Leucopenia and treatment efficacy in advanced nasopharyngeal carcinoma

Zhen Su, Yan-Ping Mao, Pu-Yun OuYang, Jie Tang, Xiao-Wen Lan, Fang-Yun Xie

Open Access Research article

Low expression levels of hepsin and TMPRSS3 are associated with poor breast cancer survival

Mikko Pelkonen, Kaisa Luostari, Maria Tengström, Hermanni Ahonen, Bozena Berdel, Vesa Kataja, Ylermi Soini, Veli-Matti Kosma, Arto Mannermaa

Open Access Study protocol

BCG+MMC trial: adding mitomycin C to BCG as adjuvant intravesical therapy for high-risk, non-muscle-invasive bladder cancer: a randomised phase III trial (ANZUP 1301)

Dickon Hayne, Martin Stockler, Steve P. McCombie, Venu Chalasani, Anne Long, Andrew Martin, Shomik Sengupta, Ian D. Davis

Open Access Research article

Polymorphisms and plasma levels of IL-27: impact on genetic susceptibility and clinical outcome of bladder cancer

Bin Zhou, Peng Zhang, Tielong Tang, Hong Liao, Kui Zhang, Yan Pu, Peng Chen, Yaping Song, Lin Zhang

Open Access Research article

Effect of genetic ancestry on leukocyte global DNA methylation in cancer patients

Mónica Cappetta, María Berdasco, Jimena Hochmann, Carolina Bonilla, Mónica Sans, Pedro C Hidalgo, Nora Artagaveytia, Rick Kittles, Miguel Martínez, Manel Esteller, Bernardo Bertoni

Open Access Research article

Effects of statin use on volumetric mammographic density: results from the KARMA study

Ida Skarping, Judith S. Brand, Per Hall, Signe Borgquist

Open Access Research article

Compounds identified by virtual docking to a tetrameric EGFR extracellular domain can modulate Grb2 internalization

Ursula D. Ramirez, Anna S. Nikonova, Hanqing Liu, Anna Pecherskaya, Sarah H. Lawrence, Ilya G. Serebriiskii, Yan Zhou, Matthew K. Robinson, Margret B. Einarson, Erica A. Golemis, Eileen K. Jaffe

Open Access Research article

MicroRNA-217 functions as a prognosis predictor and inhibits colorectal cancer cell proliferation and invasion via an AEG-1 dependent mechanism

Bo Wang, Zhan-long Shen, Ke-wei Jiang, Gang Zhao, Chun-you Wang, Yi-chao Yan, Yang Yang, Ji-zhun Zhang, Chao Shen, Zhi-dong Gao, Ying-jiang Ye, Shan Wang

Open Access Research article

Micro actions in colorectal cancer screening participation: a population-based survey study

Siu Hing Lo, Jo Waller, Charlotte Vrinten, Christian von Wagner

Open Access Research article

A GSDMB enhancer-driven HSV thymidine kinase-expressing vector for controlling occult peritoneal dissemination of gastric cancer cells

Norihisa Saeki, Rie Komatsuzaki, Fumiko Chiwaki, Kazuyoshi Yanagihara, Hiroki Sasaki

Open Access Research article

17β-estradiol induces stearoyl-CoA desaturase-1 expression in estrogen receptor-positive breast cancer cells

Anissa Belkaid, Sabrina R. Duguay, Rodney J. Ouellette, Marc E. Surette

Open Access Research article

Prognostic impact of CXCL16 and CXCR6 in non-small cell lung cancer: combined high CXCL16 expression in tumor stroma and cancer cells yields improved survival

Sigurd M. Hald, Yury Kiselev, Samer Al-Saad, Elin Richardsen, Charles Johannessen, Marte Eilertsen, Thomas K. Kilvaer, Khalid Al-Shibli, Sigve Andersen, Lill-Tove Busund, Roy M. Bremnes, Tom Donnem

Open Access Case report

Multiple gene aberrations and breast cancer: lessons from super-responders

Jennifer J. Wheler, Johnique T. Atkins, Filip Janku, Stacy L. Moulder, Roman Yelensky, Philip J. Stephens, Razelle Kurzrock

Open Access Study protocol

Early Palliative Care—Health services research and implementation of sustainable changes: the study protocol of the EVI project

Cornelia Meffert, Jan Gaertner, Katharina Seibel, Karin Jors, Hubert Bardenheuer, Dieter Buchheidt, Regine Mayer-Steinacker, Marén Viehrig, Christina Paul, Stephanie Stock, Carola Xander, Gerhild Becker

Open Access Research article

Identification of markers that functionally define a quiescent multiple myeloma cell sub-population surviving bortezomib treatment

Alfred Adomako, Veronica Calvo, Noa Biran, Keren Osman, Ajai Chari, James C Paton, Adrienne W Paton, Kateri Moore, Denis M Schewe, Julio A Aguirre-Ghiso

Open Access Case report

Psychogenic fever in a patient with small cell lung cancer: a case report

Mengdan Xu, Xiaoye Zhang, Zhaoguo Xu, Guoyuan Cui, Li Yu, Xiaoying Qi, Jia Lin, Yan Liu

Open Access Research article

Childhood cancer mortality in Japan, 1980–2013

Limin Yang, Junichiro Fujimoto

Open Access Research article

Lymph node density as a prognostic variable in node-positive bladder cancer: a meta-analysis

Ja Hyeon Ku, Minyong Kang, Hyung Suk Kim, Chang Wook Jeong, Cheol Kwak, Hyeon Hoe Kim

Open Access Research article

miR-16 promotes the apoptosis of human cancer cells by targeting FEAT

Hongwei Liang, Zheng Fu, Xueyuan Jiang, Nan Wang, Feng Wang, Xueliang Wang, Suyang Zhang, Yanbo Wang, Xin Yan, Wen-xian Guan, Chen-Yu Zhang, Ke Zen, Yujing Zhang, Xi Chen, Guangxin Zhou

Open Access Research article

Consumption of hot beverages and foods and the risk of esophageal cancer: a meta-analysis of observational studies

Yawen Chen, Yeqing Tong, Chen Yang, Yong Gan, Huilian Sun, Huashan Bi, Shiyi Cao, Xiaoxv Yin, Zuxun Lu

Open Access Research article

c-Met in esophageal squamous cell carcinoma: an independent prognostic factor and potential therapeutic target

Yohei Ozawa, Yasuhiro Nakamura, Fumiyoshi Fujishima, Saulo JA Felizola, Kenichiro Takeda, Hiroshi Okamoto, Ken Ito, Hirotaka Ishida, Takuro Konno, Takashi Kamei, Go Miyata, Noriaki Ohuchi, Hironobu Sasano

Open Access Study protocol

Randomized phase II study of S-1 dosing schedule for resected colorectal cancer

Chu Matsuda, Mamoru Uemura, Ken Nakata, Tatsushi Shingai, Junichi Nishimura, Taishi Hata, Masakazu Ikenaga, Ichiro Takemasa, Tsunekazu Mizushima, Takeshi Kato, Masataka Ikeda, Masayuki Ohue, Kohei Murata, Junichi Hasegawa, Taroh Satoh, Hirofumi Yamamoto, Mitsugu Sekimoto, Riichiro Nezu, Yuichiro Doki, Masaki Mori

Open Access Research article

TIF1γ interferes with TGFβ1/SMAD4 signaling to promote poor outcome in operable breast cancer patients

Loay Kassem, Mathieu Deygas, Laurent Fattet, Jonathan Lopez, Thibaut Goulvent, Emilie Lavergne, Sylvie Chabaud, Nicolas Carrabin, Nicolas Chopin, Thomas Bachelot, Germain Gillet, Isabelle Treilleux, Ruth Rimokh

Open Access Research article

Identification and validation of dysregulated MAPK7 (ERK5) as a novel oncogenic target in squamous cell lung and esophageal carcinoma

Paul R. Gavine, Mei Wang, Dehua Yu, Eva Hu, Chunlei Huang, Jenny Xia, Xinying Su, Joan Fan, Tianwei Zhang, Qingqing Ye, Li Zheng, Guanshan Zhu, Ziliang Qian, Qingquan Luo, Ying Yong Hou, Qunsheng Ji

Open Access Research article

Vinflunine in routine clinical practice for the treatment of advanced or metastatic urothelial cell carcinoma - data from a prospective, multicenter experience

Margitta Retz, Patrick de Geeter, Peter J. Goebell, Ullrich Matz, Wito de Schultz, Axel Hegele

Open Access Research article

Matrix metalloproteases as maestros for the dual role of LPS- and IL-10-stimulated macrophages in cancer cell behaviour

Ana P. Cardoso, Marta L. Pinto, Ana T. Pinto, Marta T. Pinto, Cátia Monteiro, Marta I. Oliveira, Susana G. Santos, João B. Relvas, Raquel Seruca, Alberto Mantovani, Marc Mareel, Mário A. Barbosa, Maria J. Oliveira

Open Access Research article

APC selectively mediates response to chemotherapeutic agents in breast cancer

Monica K. VanKlompenberg, Claire O. Bedalov, Katia Fernandez Soto, Jenifer R. Prosperi

Open Access Research article

Categorical versus continuous circulating tumor cell enumeration as early surrogate marker for therapy response and prognosis during docetaxel therapy in metastatic prostate cancer patients

Mark Thalgott, Brigitte Rack, Matthias Eiber, Michael Souvatzoglou, Matthias M. Heck, Caroline Kronester, Ulrich Andergassen, Victoria Kehl, Bernd J. Krause, Jurgen E. Gschwend, Margitta Retz, Roman Nawroth

Open Access Study protocol

Cohort profile: cholangiocarcinoma screening and care program (CASCAP)

Narong Khuntikeo, Nittaya Chamadol, Puangrat Yongvanit, Watcharin Loilome, Nisana Namwat, Paiboon Sithithaworn, Ross H. Andrews, Trevor N. Petney, Supannee Promthet, Kavin Thinkhamrop, Chaiwat Tawarungruang, Bandit Thinkhamrop

Open Access Research article

Intratumor cholesteryl ester accumulation is associated with human breast cancer proliferation and aggressive potential: a molecular and clinicopathological study

David de Gonzalo-Calvo, Laura López-Vilaró, Laura Nasarre, Maitane Perez-Olabarria, Tania Vázquez, Daniel Escuin, Lina Badimon, Agusti Barnadas, Enrique Lerma, Vicenta Llorente-Cortés

Open Access Research article

MiR-223 targeting MAFB suppresses proliferation and migration of nasopharyngeal carcinoma cells

Wanyong Yang, Xi Lan, Dongmin Li, Tao Li, Shemin Lu

Open Access Research article

Combined inhibition of the cell cycle related proteins Wee1 and Chk1/2 induces synergistic anti-cancer effect in melanoma

Gry Irene Magnussen, Elisabeth Emilsen, Karianne Giller Fleten, Birgit Engesæter, Viola Nähse-Kumpf, Roar Fjær, Ana Slipicevic, Vivi Ann Flørenes

Open Access Research article

Enhanced caveolin-1 expression increases migration, anchorage-independent growth and invasion of endometrial adenocarcinoma cells

Natalia Diaz-Valdivia, Denisse Bravo, Hernán Huerta, Soledad Henriquez, Fernando Gabler, Margarita Vega, Carmen Romero, Claudia Calderon, Gareth I. Owen, Lisette Leyton, Andrew F. G. Quest

Open Access Research article

Cytotoxic effects of replication-competent adenoviruses on human esophageal carcinoma are enhanced by forced p53 expression

Shan Yang, Kiyoko Kawamura, Shinya Okamoto, Suguru Yamauchi, Masato Shingyoji, Ikuo Sekine, Hiroshi Kobayashi, Yuji Tada, Koichiro Tatsumi, Kenzo Hiroshima, Hideaki Shimada, Masatoshi Tagawa

Open Access Research article

Conventional transarterial chemoembolization versus drug-eluting bead transarterial chemoembolization for the treatment of hepatocellular carcinoma

Roman Kloeckner, Arndt Weinmann, Friederike Prinz, Daniel Pinto dos Santos, Christian Ruckes, Christoph Dueber, Michael Bernhard Pitton

Open Access Technical advance

A 3D-microtissue-based phenotypic screening of radiation resistant tumor cells with synchronized chemotherapeutic treatment

Nataša Anastasov, Ines Höfig, Vanja Radulović, Simon Ströbel, Michael Salomon, Jan Lichtenberg, Ina Rothenaigner, Kamyar Hadian, Jens M. Kelm, Christian Thirion, Michael J. Atkinson

Open Access Research article

The prognostic role of HER2 expression in ductal breast carcinoma in situ (DCIS); a population-based cohort study

Signe Borgquist, Wenjing Zhou, Karin Jirström, Rose-Marie Amini, Thomas Sollie, Therese Sørlie, Carl Blomqvist, Salma Butt, Fredrik Wärnberg

Open Access Research article

TRIM8 downregulation in glioma affects cell proliferation and it is associated with patients survival

Lucia Micale, Carmela Fusco, Andrea Fontana, Raffaela Barbano, Bartolomeo Augello, Pasquelena De Nittis, Massimiliano Copetti, Maria Teresa Pellico, Barbara Mandriani, Dario Cocciadiferro, Paola Parrella, Vito Michele Fazio, Lucia Maria Cecilia Dimitri, Vincenzo D’Angelo, Chiara Novielli, Lidia Larizza, Antonio Daga, Giuseppe Merla

Open Access Research article

The role of the REG4 gene and its encoding product in ovarian epithelial carcinoma

Shuo Chen, Wen-Feng Gou, Shuang Zhao, Zhe-Feng Niu, Yang Zhao, Yasuo Takano, Hua-Chuan Zheng

Open Access Research article

A microRNA molecular modeling extension for prediction of colorectal cancer treatment

Jian Li, Ulrich R. Mansmann

Open Access Research article

Gene expression profiling leads to discovery of correlation of matrix metalloproteinase 11 and heparanase 2 in breast cancer progression

Junjie Fu, Ravil Khaybullin, Yanping Zhang, Amy Xia, Xin Qi

Open Access Research article

The combination of methylsulfonylmethane and tamoxifen inhibits the Jak2/STAT5b pathway and synergistically inhibits tumor growth and metastasis in ER-positive breast cancer xenografts

Nipin SP, Pramod Darvin, Young Beom Yoo, Youn Hee Joung, Dong Young Kang, Don Nam Kim, Tae Sook Hwang, Sang Yoon Kim, Wan Seop Kim, Hak Kyo Lee, Byung Wook Cho, Heui Soo Kim, Kyung Do Park, Jong Hwan Park, Soung Hoon Chang, Young Mok Yang

Open Access Study protocol

Concept and design of a nationwide prospective feasibility/efficacy/safety study of weekly paclitaxel for patients with pathologically confirmed anaplastic thyroid cancer (ATCCJ-PTX-P2)

Naoyoshi Onoda, Iwao Sugitani, Takuya Higashiyama, Hisato Hara, Ken-ichi Ito, Makoto Kammori, Kiminori Sugino, Shinichi Suzuki, Kazuhisa Toda, Akira Yoshida, Akira Miyauchi

Open Access Research article

Constitutive expression of Bcl-2 induces epithelial-Mesenchymal transition in mammary epithelial cells

Juan An, Jin Lv, Aimin Li, Junxiao Qiao, Liang Fang, Zhihua Li, Bo Li, Wei Zhao, Huoming Chen, Liying Wang

Open Access Research article

Effect of sulfasalazine on human neuroblastoma: analysis of sepiapterin reductase (SPR) as a new therapeutic target

Lisette P. Yco, Dirk Geerts, Gabor Mocz, Jan Koster, André S. Bachmann

Open Access Research article

A cross-sectional study of high-risk human papillomavirus clustering and cervical outcomes in HIV-infected women in Rio de Janeiro, Brazil

Jessica L. Castilho, José Eduardo Levi, Paula M. Luz, Mary Catherine Cambou, Tazio Vanni, Angela de Andrade, Mônica Derrico, Valdiléa G. Veloso, Beatriz Grinsztejn, Ruth K. Friedman

Open Access Research article

Pharmacological targeting of valosin containing protein (VCP) induces DNA damage and selectively kills canine lymphoma cells

Marie-Ève Nadeau, Charlène Rico, Mayra Tsoi, Mélanie Vivancos, Sabin Filimon, Marilène Paquet, Derek Boerboom

Open Access Research article

LTA + 252A > G polymorphism is associated with risk of nasal NK/T-cell lymphoma in a Chinese population: a case-control study

Sensen Cheng, Jianzhong Li, Wenjian Liu, Chengxiang Liu, Lei Su, Xiuchun Liu, Liangjun Guo, Yuan Ma, Bao Song, Jie Liu

Open Access Research article

Quantitative proteomic analysis shows differentially expressed HSPB1 in glioblastoma as a discriminating short from long survival factor and NOVA1 as a differentiation factor between low-grade astrocytoma and oligodendroglioma

Marcela Gimenez, Suely Kazue Nagahashi Marie, Sueli Oba-Shinjo, Miyuki Uno, Clarice Izumi, João Bosco Oliveira, Jose Cesar Rosa

Open Access Study protocol

Investigating the performance and cost-effectiveness of the simple ultrasound-based rules compared to the risk of malignancy index in the diagnosis of ovarian cancer (SUBSONiC-study): protocol of a prospective multicenter cohort study in the Netherlands

Evelyne MJ Meys, Iris JG Rutten, Roy FPM Kruitwagen, Brigitte F Slangen, Martin GM Bergmans, Helen JMM Mertens, Ernst Nolting, Dieuwke Boskamp, Regina GH Beets-Tan, Toon van Gorp

Open Access Research article

Menacalc, a quantitative method of metastasis assessment, as a prognostic marker for axillary node-negative breast cancer

Catherine L. Forse, Seema Agarwal, Dushanthi Pinnaduwage, Frank Gertler, John S. Condeelis, Juan Lin, Xiaonan Xue, Kimberly Johung, Anna Marie Mulligan, Thomas E. Rohan, Shelley B. Bull, Irene L. Andrulis

Open Access Research article

The prognostic impact of mutations in spliceosomal genes for myelodysplastic syndrome patients without ring sideroblasts

Min-Gu Kang, Hye-Ran Kim, Bo-Young Seo, Jun Hyung Lee, Seok-Yong Choi, Soo-Hyun Kim, Jong-Hee Shin, Soon-Pal Suh, Jae-Sook Ahn, Myung-Geun Shin

Open Access Research article

Distribution of cervical intraepithelial neoplasia on the cervix in Chinese women: pooled analysis of 19 population based screening studies

Yu-qian Zhao, Irene J. Chang, Fang-hui Zhao, Shang-ying Hu, Jennifer S. Smith, Xun Zhang, Shu-min Li, Ping Bai, Wen-hua Zhang, You-lin Qiao

Open Access Research article

Multimodality therapy approaches, local and systemic treatment, compared with chemotherapy alone in recurrent glioblastoma

Marta Scorsetti, Pierina Navarria, Federico Pessina, Anna Maria Ascolese, Giuseppe D’Agostino, Stefano Tomatis, Fiorenza De Rose, Elisa Villa, Giulia Maggi, Matteo Simonelli, Elena Clerici, Riccardo Soffietti, Armando Santoro, Luca Cozzi, Lorenzo Bello

Open Access Study protocol

PIpelle Prospective ENDOmetrial carcinoma (PIPENDO) study, pre-operative recognition of high risk endometrial carcinoma: a multicentre prospective cohort study

Nicole C. M. Visser, Johan Bulten, Anneke A. M. van der Wurff, Erik A. Boss, Carolien M. Bronkhorst, Harrie W. H. Feijen, Joke E. Haartsen, Hilde A. D. M. van Herk, Ineke M. de Kievit, Paul J. J. M. Klinkhamer, Brenda M. Pijlman, Marc P. M. L. Snijders, Ingrid Vandenput, M. Caroline Vos, Peter E. J. de Wit, Lonneke V. van de Poll-Franse, Leon F.A.G. Massuger, Johanna M. A. Pijnenborg

Open Access Research article

The truncated splice variant of peroxisome proliferator-activated receptor alpha, PPARα-tr, autonomously regulates proliferative and pro-inflammatory genes

Maria Thomas, Christine Bayha, Kathrin Klein, Simon Müller, Thomas S. Weiss, Matthias Schwab, Ulrich M. Zanger

Open Access Research article

Anticancer drug sensitivity prediction in cell lines from baseline gene expression through recursive feature selection

Zuoli Dong, Naiqian Zhang, Chun Li, Haiyun Wang, Yun Fang, Jun Wang, Xiaoqi Zheng

Open Access Study protocol

Helping cancer patients quit smoking by increasing their risk perception: a study protocol of a cluster randomized controlled trial

William H.C. Li, Sophia S.C. Chan, Kelvin M. P. Wang, T.H. Lam

Open Access Research article

Estrogen receptor α enhances the transcriptional activity of ETS-1 and promotes the proliferation, migration and invasion of neuroblastoma cell in a ligand dependent manner

Peng Cao, Fan Feng, Guofu Dong, Chunyong Yu, Sizhe Feng, Erlin Song, Guobing Shi, Yong Liang, Guobiao Liang

Open Access Research article

Inflammation-regulating factors in ascites as predictive biomarkers of drug resistance and progression-free survival in serous epithelial ovarian cancers

Denis Lane, Isabelle Matte, Perrine Garde-Granger, Claude Laplante, Alex Carignan, Claudine Rancourt, Alain Piché

Open Access Research article

Evaluation of the efficacy and safety of lanreotide in combination with targeted therapies in patients with neuroendocrine tumours in clinical practice: a retrospective cross-sectional analysis

Jaume Capdevila, Isabel Sevilla, Vicente Alonso, Luís Antón Aparicio, Paula Jiménez Fonseca, Enrique Grande, Juan José Reina, José Luís Manzano, Juan Domingo Alonso Lájara, Jorge Barriuso, Daniel Castellano, Javier Medina, Carlos López, Ángel Segura, Sergio Carrera, Guillermo Crespo, José Fuster, Javier Munarriz, Pilar García Alfonso

Open Access Study protocol

STRATEGIC-1: A multiple-lines, randomized, open-label GERCOR phase III study in patients with unresectable wild-type RAS metastatic colorectal cancer

Benoist Chibaudel, Franck Bonnetain, Christophe Tournigand, Marine Hug de Larauze, Armand de Gramont, Pierre Laurent-Puig, Jérôme Paget, Alexandra Hadengue, Dominique Notelet, Magdalena Benetkiewicz, Thierry André, Aimery de Gramont

Open Access Research article

Variations of BRAF mutant allele percentage in melanomas

Zofia Hélias-Rodzewicz, Elisa Funck-Brentano, Laure Baudoux, Chan Kwon Jung, Ute Zimmermann, Cristi Marin, Thierry Clerici, Catherine Le Gall, Frédérique Peschaud, Valérie Taly, Philippe Saiag, Jean-François Emile

Open Access Research article

The different role of intratumoral and peritumoral lymphangiogenesis in gastric cancer progression and prognosis

Kyung Ho Pak, Ara Jo, Hye Ji Choi, Younghee Choi, Hyunki Kim, Jae-Ho Cheong

Open Access Research article

MiR-190b, the highest up-regulated miRNA in ERα-positive compared to ERα-negative breast tumors, a new biomarker in breast cancers?

Geraldine Cizeron-Clairac, François Lallemand, Sophie Vacher, Rosette Lidereau, Ivan Bieche, Celine Callens

Open Access Research article

The Functionality Assessment Flowchart (FAF): a new simple and reliable method to measure performance status with a high percentage of agreement between observers

Carlos Eduardo Paiva, Felipe Augusto Ferreira Siquelli, Henrique Amorim Santos, Marina Moreira Costa, Daniella Ramone Massaro, Domício Carvalho Lacerda, João Soares Nunes, Cristiano de Pádua Souza, Bianca Sakamoto Ribeiro Paiva

Open Access Research article

The expression of aldehyde dehydrogenase 1 (ALDH1) in ovarian carcinomas and its clinicopathological associations: a retrospective study

Ruixia Huang, Xiaoran Li, Ruth Holm, Claes G. Trope, Jahn M. Nesland, Zhenhe Suo

Open Access Study protocol

ComOn Coaching: Study protocol of a randomized controlled trial to assess the effect of a varied number of coaching sessions on transfer into clinical practice following communication skills training

Marcelo Niglio de Figueiredo, Bärbel Rodolph, Carma L Bylund, Tanja Goelz, Pia Heußner, Heribert Sattel, Kurt Fritzsche, Alexander Wuensch

Open Access Research article

Enhanced efficacy of photodynamic therapy by inhibiting ABCG2 in colon cancers

Ju Hee Kim, Jae Myung Park, Yoon Jin Roh, In-Wook Kim, Tayyaba Hasan, Myung-Gyu Choi

Open Access Research article

Enhancing adherence in trials promoting change in diet and physical activity in individuals with a diagnosis of colorectal adenoma; a systematic review of behavioural intervention approaches

Deborah McCahon, Amanda J. Daley, Janet Jones, Richard Haslop, Arjun Shajpal, Aliki Taylor, Sue Wilson, George Dowswell

Open Access Research article

Comparative microRNA profiling of sporadic and BRCA1 associated basal-like breast cancers

Max Yan, Kristy Shield-Artin, David Byrne, Siddhartha Deb, Nic Waddell, Izhak Haviv, Stephen B Fox

Open Access Case report

Acrokeratosis paraneoplastica in serous ovarian carcinoma: case report

Aline Hempen, Eleftherios P Samartzis, Jivko Kamarachev, Daniel Fink, Konstantin J Dedes

Open Access Research article

Polish experience of lenalidomide in the treatment of lower risk myelodysplastic syndrome with isolated del(5q)

Aleksandra Butrym, Ewa Lech-Maranda, Elżbieta Patkowska, Beata Kumiega, Maria Bieniaszewska, Andrzej Mital, Krzysztof Madry, Tigran Torosian, Ryszard Wichary, Justyna Rybka, Krzysztof Warzocha, Grzegorz Mazur

Open Access Research article

Methylation-associated Has-miR-9 deregulation in paclitaxel- resistant epithelial ovarian carcinoma

Xiao Li, Qianqian Pan, Xiaoyun Wan, Yuyan Mao, Weiguo Lu, Xing Xie, Xiaodong Cheng

Open Access Study protocol

Neoadjuvant FOLFOX 4 versus FOLFOX 4 with Cetuximab versus immediate surgery for high-risk stage II and III colon cancers: a multicentre randomised controlled phase II trial – the PRODIGE 22 - ECKINOXE trial

Mehdi Karoui, Anne Rullier, Alain Luciani, Franck Bonnetain, Marie-Luce Auriault, Antony Sarran, Geneviève Monges, Hervé Trillaud, Karine Le Malicot, Karen Leroy, Iradj Sobhani, Armelle Bardier, Marie Moreau, Isabelle Brindel, Jean François Seitz, Julien Taieb

Open Access Study protocol

The Breast Cancer to Bone (B2B) Metastases Research Program: a multi-disciplinary investigation of bone metastases from breast cancer

Nigel T. Brockton, Stephanie J. Gill, Stephanie L. Laborge, Alexander H. G. Paterson, Linda S. Cook, Hans J. Vogel, Carrie S. Shemanko, David A. Hanley, Anthony M. Magliocco, Christine M. Friedenreich

Open Access Case report

The combination of intravenous Reolysin and gemcitabine induces reovirus replication and endoplasmic reticular stress in a patient with KRAS-activated pancreatic cancer

Devalingam Mahalingam, Sukeshi Patel, Gerard Nuovo, George Gill, Giovanni Selvaggi, Matt Coffey, Steffan T. Nawrocki

Open Access Research article

Acquired genetic alterations in tumor cells dictate the development of high-risk neuroblastoma and clinical outcomes

Faizan H. Khan, Vijayabaskar Pandian, Satishkumar Ramraj, Mohan Natarajan, Sheeja Aravindan, Terence S. Herman, Natarajan Aravindan

Open Access Research article

Noncompliance to guidelines in head and neck cancer treatment; associated factors for both patient and physician

Emilie A. C. Dronkers, Steven W. Mes, Marjan H. Wieringa, Marc P. van der Schroeff, Robert J. Baatenburg de Jong

Open Access Research article

Pan-cancer analysis of TCGA data reveals notable signaling pathways

Richard Neapolitan, Curt M. Horvath, Xia Jiang

Open Access Research article

Locally ablative treatment of breast cancer liver metastases: identification of factors influencing survival (the Mammary Cancer Microtherapy and Interventional Approaches (MAMMA MIA) study)

Max Seidensticker, Benjamin Garlipp, Sophia Scholz, Konrad Mohnike, Felix Popp, Ingo Steffen, Ricarda Seidensticker, Patrick Stübs, Maciej Pech, Maciej PowerskI, Peter Hass, Serban-Dan Costa, Holger Amthauer, Christiane Bruns, Jens Ricke

Open Access Research article

Expression of pre-selected TMEMs with predicted ER localization as potential classifiers of ccRCC tumors

Tomasz Wrzesiński, Malgorzata Szelag, Wojciech A. Cieślikowski, Agnieszka Ida, Rachel Giles, Elżbieta Zodro, Joanna Szumska, Joanna Poźniak, Zbigniew Kwias, Hans A.R. Bluyssen, Joanna Wesoly

Open Access Research article

Prospective cohort study using the breast cancer spheroid model as a predictor for response to neoadjuvant therapy – the SpheroNEO study

Kathrin Halfter, Nina Ditsch, Hans-Christian Kolberg, Holger Fischer, Tanja Hauzenberger, Franz Edler von Koch, Ingo Bauerfeind, Gunter von Minckwitz, Ilona Funke, Alexander Crispin, Barbara Mayer

Open Access Research article

Ki-67 as a prognostic marker in early-stage non-small cell lung cancer in Asian patients: a meta-analysis of published studies involving 32 studies

Song Wen, Wei Zhou, Chun-ming Li, Juan Hu, Xiao-ming Hu, Ping Chen, Guo-liang Shao, Wu-hua Guo

Open Access Research article

The prognostic significance of the postoperative prognostic nutritional index in patients with colorectal cancer

Masatsune Shibutani, Kiyoshi Maeda, Hisashi Nagahara, Hiroshi Ohtani, Yasuhito Iseki, Tetsuro Ikeya, Kenji Sugano, Kosei Hirakawa

Open Access Research article

A new anti-glioma therapy, AG119: pre-clinical assessment in a mouse GL261 glioma model

Rheal A. Towner, Michael Ihnat, Debra Saunders, Anja Bastian, Nataliya Smith, Roheeth Kumar Pavana, Aleem Gangjee

Open Access Research article

Spectrum and frequencies of BRCA1/2 mutations in Bulgarian high risk breast cancer patients

Rumyana Ivanova Dodova, Atanaska Velichkova Mitkova, Daniela Rosenova Dacheva, Lina Basam Hadjo, Alexandrina Ivanova Vlahova, Margarita Stoyanova Taushanova - Hadjieva, Spartak Stoyanov Valev, Marija Mitko Caulevska, Stanislava Dimitrova Popova, Ivan Emilov Popov, Tihomir Iliichev Dikov, Theophil Angelov Sedloev, Atanas Stefanov Ionkov, Konstanta Velinova Timcheva, Svetlana Liubomirova Christova, Ivo Marinov Kremensky, Vanio Ivanov Mitev, Radka Petrova Kaneva

Open Access Research article

Expression of an estrogen-regulated variant transcript of the peroxisomal branched chain fatty acid oxidase ACOX2 in breast carcinomas

Sunniva Stordal Bjørklund, Vessela N. Kristensen, Michael Seiler, Surendra Kumar, Grethe I. Grenaker Alnæs, Yao Ming, John Kerrigan, Bjørn Naume, Ravi Sachidanandam, Gyan Bhanot, Anne-Lise Børresen-Dale, Shridar Ganesan

Open Access Research article

A small molecular agent YL529 inhibits VEGF-D-induced lymphangiogenesis and metastasis in preclinical tumor models in addition to its known antitumor activities

Youzhi Xu, Wenjie Lu, Peng Yang, Wen Peng, Chunting Wang, Manli Li, Yan Li, Guobo Li, Nana Meng, Hongjun Lin, Lixin Kan, Siying Wang, Shengyong Yang, Luoting Yu, YingLan Zhao

Open Access Study protocol

Audiovisual biofeedback breathing guidance for lung cancer patients receiving radiotherapy: a multi-institutional phase II randomised clinical trial

Sean Pollock, Ricky O’Brien, Kuldeep Makhija, Fiona Hegi-Johnson, Jane Ludbrook, Angela Rezo, Regina Tse, Thomas Eade, Roland Yeghiaian-Alvandi, Val Gebski, Paul J Keall

Open Access Research article

STAT3 polymorphism and Helicobacter pylori CagA strains with higher number of EPIYA-C segments independently increase the risk of gastric cancer

Gifone A Rocha, Andreia MC Rocha, Adriana D Gomes, César LL Faria Jr, Fabrício F Melo, Sérgio A Batista, Viviane C Fernandes, Nathálie BF Almeida, Kádima N Teixeira, Kátia S Brito, Dulciene Maria Magalhães Queiroz

Open Access Research article

Targeting mTOR/p70S6K/glycolysis signaling pathway restores glucocorticoid sensitivity to 4E-BP1 null Burkitt Lymphoma

Ling Gu, Liping Xie, Chuan Zuo, Zhigui Ma, Yanle Zhang, Yiping Zhu, Ju Gao

Open Access Research article

Tumour shrinkage at 6 weeks predicts favorable clinical outcomes in a phase III study of gemcitabine and oxaliplatin with or without erlotinib for advanced biliary tract cancer

Seung Tae Kim, Kee-Taek Jang, Su Jin Lee, Hye-Lim Jang, Jeeyun Lee, Se Hoon Park, Young Suk Park, Ho Yeong Lim, Won Ki Kang, Joon Oh Park

Open Access Research article

Nrf2 is a potential prognostic marker and promotes proliferation and invasion in human hepatocellular carcinoma

Mingxin Zhang, Chao Zhang, Lingmin Zhang, Qi Yang, Suna Zhou, Qinsheng Wen, Jingjie Wang

Open Access Study protocol

TOPGEAR: a randomised phase III trial of perioperative ECF chemotherapy versus preoperative chemoradiation plus perioperative ECF chemotherapy for resectable gastric cancer (an international, intergroup trial of the AGITG/TROG/EORTC/NCIC CTG)

Trevor Leong, B Mark Smithers, Michael Michael, Val Gebski, Alex Boussioutas, Danielle Miller, John Simes, John Zalcberg, Karin Haustermans, Florian Lordick, Christoph Schuhmacher, Carol Swallow, Gail Darling, Rebecca Wong

Open Access Research article

Relationship between circulating tumor cells and epithelial to mesenchymal transition in early breast cancer

M. Mego, Z. Cierna, P. Janega, M. Karaba, G. Minarik, J. Benca, T. Sedlácková, G. Sieberova, P. Gronesova, D. Manasova, D. Pindak, J. Sufliarsky, L. Danihel, JM Reuben, J. Mardiak

Open Access Research article

Monitoring therapeutic efficacy of sunitinib using [18F]FDG and [18F]FMISO PET in an immunocompetent model of luminal B (HER2-positive)-type mammary carcinoma

Benoît Thézé, Nicholas Bernards, Audrey Beynel, Stephan Bouet, Bertrand Kuhnast, Irène Buvat, Bertrand Tavitian, Raphaël Boisgard

Open Access Case report

Collapsing focal segmental glomerulosclerosis following long-term treatment with oral ibandronate: case report and review of literature

Ning Jia, Fionnuala C. Cormack, Bin Xie, Zita Shiue, Behzad Najafian, Julie R. Gralow

Open Access Research article

Overexpression of Class III β-tubulin, Sox2, and nuclear Survivin is predictive of taxane resistance in patients with stage III ovarian epithelial cancer

Jintong Du, Bei Li, Yingli Fang, Yanguo Liu, Yang Wang, Jisheng Li, Wen Zhou, Xiuwen Wang

Open Access Research article

Linear accelerator-based stereotactic radiosurgery in 140 brain metastases from malignant melanoma

Henrik Hauswald, Alina Stenke, Jürgen Debus, Stephanie E. Combs

Open Access Research article

The prognostic value of SUMO1/Sentrin specific peptidase 1 (SENP1) in prostate cancer is limited to ERG-fusion positive tumors lacking PTEN deletion

Christoph Burdelski, Devi Menan, Maria Christina Tsourlakis, Martina Kluth, Claudia Hube-Magg, Nathaniel Melling, Sarah Minner, Christina Koop, Markus Graefen, Hans Heinzer, Corinna Wittmer, Guido Sauter, Ronald Simon, Thorsten Schlomm, Stefan Steurer, Till Krech

Open Access Research article

Whole-exome sequencing of a rare case of familial childhood acute lymphoblastic leukemia reveals putative predisposing mutations in Fanconi anemia genes

Jean-François Spinella, Jasmine Healy, Virginie Saillour, Chantal Richer, Pauline Cassart, Manon Ouimet, Daniel Sinnett

Open Access Research article

Functional role of miR-10b in tamoxifen resistance of ER-positive breast cancer cells through down-regulation of HDAC4

Aamir Ahmad, Kevin R. Ginnebaugh, Shuping Yin, Aliccia Bollig-Fischer, Kaladhar B. Reddy, Fazlul H. Sarkar

Open Access Research article

The burden of cervical pre-cancer and cancer in HIV positive women in Zambia: a modeling study

Allen C. Bateman, Katundu Katundu, Mulindi H. Mwanahamuntu, Sharon Kapambwe, Vikrant V. Sahasrabuddhe, Michael L. Hicks, Benjamin H. Chi, Jeffrey S. A. Stringer, Groesbeck P. Parham, Carla J. Chibwesha

Open Access Research article

Functional microRNA high throughput screening reveals miR-9 as a central regulator of liver oncogenesis by affecting the PPARA-CDH1 pathway

Alexandra Drakaki, Maria Hatziapostolou, Christos Polytarchou, Christina Vorvis, George A. Poultsides, John Souglakos, Vassilis Georgoulias, Dimitrios Iliopoulos

Open Access Research article

Early increase in circulating carbonic anhydrase IX during neoadjuvant treatment predicts favourable outcome in locally advanced rectal cancer

Helga Helseth Hektoen, Kjersti Flatmark, Yvonne Andersson, Svein Dueland, Kathrine Røe Redalen, Anne Hansen Ree

Open Access Study protocol

Association of sarcopenia and observed physical performance with attainment of multidisciplinary team planned treatment in non-small cell lung cancer: an observational study protocol

Jemima T. Collins, Simon Noble, John Chester, Helen E. Davies, William D. Evans, Jason Lester, Diane Parry, Rebecca J. Pettit, Anthony Byrne

Open Access Research article

Digital imaging in the immunohistochemical evaluation of the proliferation markers Ki67, MCM2 and Geminin, in early breast cancer, and their putative prognostic value

Shalaka Joshi, Johnathan Watkins, Patrycja Gazinska, John P. Brown, Cheryl E. Gillett, Anita Grigoriadis, Sarah E. Pinder

Open Access Research article

Identifying novel hypoxia-associated markers of chemoresistance in ovarian cancer

Lynda M. McEvoy, Sharon A. O’Toole, Cathy D. Spillane, Cara M. Martin, Michael F. Gallagher, Britta Stordal, Gordon Blackshields, Orla Sheils, John J. O’Leary

Open Access Research article

Elevated C1orf63 expression is correlated with CDK10 and predicts better outcome for advanced breast cancers: a retrospective study

Chao-Qun Hong, Fan Zhang, Yan-Jie You, Wei-Li Qiu, Armando E. Giuliano, Xiao-Jiang Cui, Guo-Jun Zhang, Yu-Kun Cui

Open Access Research article

CD147 expression predicts biochemical recurrence after prostatectomy independent of histologic and pathologic features

Tyler M. Bauman, Jonathan A. Ewald, Wei Huang, William A. Ricke

Open Access Research article

GTSE1 expression represses apoptotic signaling and confers cisplatin resistance in gastric cancer cells

Vinod Vijay Subhash, Shi Hui Tan, Woei Loon Tan, Mei Shi Yeo, Chen Xie, Foong Ying Wong, Zee Ying Kiat, Robert Lim, Wei Peng Yong

Open Access Research article

IL6 secreted by Ewing sarcoma tumor microenvironment confers anti-apoptotic and cell-disseminating paracrine responses in Ewing sarcoma cells

Andrej Lissat, Mandy Joerschke, Dheeraj A. Shinde, Till Braunschweig, Angelina Meier, Anna Makowska, Rachel Bortnick, Philipp Henneke, Georg Herget, Thomas A. Gorr, Udo Kontny

Open Access Research article

P-glycoprotein confers acquired resistance to 17-DMAG in lung cancers with an ALK rearrangement

Hee Joung Kim, Kye Young Lee, Young Whan Kim, Yun Jung Choi, Jung-Eun Lee, Chang Min Choi, In-Jeoung Baek, Jin Kyung Rho, Jae Cheol Lee

Open Access Research article

Breast cancer survivors’ recollection of their illness and therapy seven years after enrolment into a randomised controlled clinical trial

Patricia Lindberg, Michael Koller, Brunhilde Steinger, Wilfried Lorenz, Jeremy C. Wyatt, Elisabeth C. Inwald, Monika Klinkhammer-Schalke

Open Access Research article

Superior efficacy of rituximab-based chemoimmunotherapy as an initial therapy in newly diagnosed patients with B cell indolent lymphomas: long-term results from a single center in China

Zengjun Li, Fei Li, Shuhua Yi, Zhimin Gu, Zhen Yu, Yan Xu, Xiaoyan Feng, Wei Liu, Dehui Zou, Junyuan Qi, Fenghuang Zhan, Lugui Qiu

Open Access Study protocol

Laparoscopic versus open gastrectomy for gastric cancer, a multicenter prospectively randomized controlled trial (LOGICA-trial)

Leonie Haverkamp, Hylke JF Brenkman, Maarten FJ Seesing, Suzanne S Gisbertz, Mark I van Berge Henegouwen, Misha DP Luyer, Grard AP Nieuwenhuijzen, Bas PL Wijnhoven, Jan JB van Lanschot, Wobbe O de Steur, Henk H Hartgrink, Jan HMB Stoot, Karel WE Hulsewé, Ernst J Spillenaar Bilgen, Jeroen E Rütter, Ewout A Kouwenhoven, Marc J van Det, Donald L van der Peet, Freek Daams, Werner A Draaisma, Ivo AMJ Broeders, Henk F van Stel, Miangela M Lacle, Jelle P Ruurda, Richard van Hillegersberg

Open Access Research article

Population-based SEER trend analysis of overall and cancer-specific survival in 5138 patients with gastrointestinal stromal tumor

Ulrich Güller, Ignazio Tarantino, Thomas Cerny, Bruno M. Schmied, Rene Warschkow

Open Access Research article

Impact of delays in initiating postoperative chemoradiation while determining the MGMT promoter-methylation statuses of patients with primary glioblastoma

Sebastian Adeberg, Tilman Bostel, Semi Harrabi, Denise Bernhardt, Thomas Welzel, Wolfgang Wick, Juergen Debus, Stephanie E. Combs

Open Access Research article

A functional genetic variant in fragile-site gene FATS modulates the risk of breast cancer in triparous women

Fangfang Song, Jun Zhang, Li Qiu, Yawen Zhao, Pan Xing, Jiachun Lu, Kexin Chen, Zheng Li

Open Access Research article

XAB2 tagSNPs contribute to non-small cell lung cancer susceptibility in Chinese population

Na Pei, Lei Cao, Yingwen Liu, Jing Wu, Qinqin Song, Zhi Zhang, Juxiang Yuan, Xuemei Zhang

Open Access Research article

A novel cytosporone 3-Heptyl-4,6-dihydroxy-3H-isobenzofuran-1-one: synthesis; toxicological, apoptotic and immunomodulatory properties; and potentiation of mutagenic damage

Rodrigo Juliano Oliveira, Stephanie Dynczuki Navarro, Dênis Pires de Lima, Alisson Meza, João Renato Pesarini, Roberto da Silva Gomes, Caroline Bilhar Karaziack, Mariana de Oliveira Mauro, Andréa Luiza Cunha-Laura, Antônio Carlos Duenhas Monreal, Wanderson Romão, Valdemar Lacerda Júnior, Adilson Beatriz

Open Access Research article

Neoplastic transformation of porcine mammary epithelial cells in vitro and tumor formation in vivo

A. R. Rowson-Hodel, R. Manjarin, J. F. Trott, R. D. Cardiff, A. D. Borowsky, R. C. Hovey

Open Access Research article

Adenosine A2b receptor promotes progression of human oral cancer

Hiroki Kasama, Yosuke Sakamoto, Atsushi Kasamatsu, Atsushi Okamoto, Tomoyoshi Koyama, Yasuyuki Minakawa, Katsunori Ogawara, Hidetaka Yokoe, Masashi Shiiba, Hideki Tanzawa, Katsuhiro Uzawa

Open Access Study protocol

Adjuvant chemotherapy with gemcitabine and cisplatin compared to observation after curative intent resection of cholangiocarcinoma and muscle invasive gallbladder carcinoma (ACTICCA-1 trial) - a randomized, multidisciplinary, multinational phase III trial

Alexander Stein, Dirk Arnold, John Bridgewater, David Goldstein, Lars Henrik Jensen, Heinz-Josef Klümpen, Ansgar W. Lohse, Björn Nashan, John Primrose, Silke Schrum, Jenny Shannon, Eik Vettorazzi, Henning Wege

Open Access Research article

Prognostic significance of multiple kallikreins in high-grade astrocytoma

Kristen L. Drucker, Caterina Gianinni, Paul A. Decker, Eleftherios P. Diamandis, Isobel A. Scarisbrick

Open Access Case report

Durable recurrence-free survival after pneumonectomy for late lung metastasis from rectal cancer: case report with genetic and epigenetic analyses

Andrea Imperatori, Nicola Rotolo, Lorenzo Dominioni, Elisa Nardecchia, Maria Cattoni, Laura Cimetti, Cristina Riva, Fausto Sessa, Daniela Furlan

Open Access Research article

Obatoclax is a direct and potent antagonist of membrane-restricted Mcl-1 and is synthetic lethal with treatment that induces Bim

Mai Nguyen, Regina Cencic, Franziska Ertel, Cynthia Bernier, Jerry Pelletier, Anne Roulston, John R. Silvius, Gordon C. Shore

Open Access Research article

Limited predictive value of achieving beneficial plasma (Z)-endoxifen threshold level by CYP2D6 genotyping in tamoxifen-treated Polish women with breast cancer

Ewa E. Hennig, Magdalena Piatkowska, Jakub Karczmarski, Krzysztof Goryca, Elzbieta Brewczynska, Radoslaw Jazwiec, Anna Kluska, Robert Omiotek, Agnieszka Paziewska, Michal Dadlez, Jerzy Ostrowski

Open Access Research article

Extracellular vesicle-mediated phenotype switching in malignant and non-malignant colon cells

Hillary E. Mulvey, Audrey Chang, Jason Adler, Michael Del Tatto, Kimberly Perez, Peter J. Quesenberry, Devasis Chatterjee

Open Access Research article

SDF-1alpha concentration dependent modulation of RhoA and Rac1 modifies breast cancer and stromal cells interaction

Jennifer Pasquier, Nadine Abu-Kaoud, Houari Abdesselem, Aisha Madani, Jessica Hoarau-Véchot, Hamda Al. Thawadi, Fabien Vidal, Bettina Couderc, Gilles Favre, Arash Rafii

Open Access Research article

Satisfaction with fertility- and sexuality-related information in young women with breast cancer—ELIPPSE40 cohort

Ali Ben Charif, Anne-Déborah Bouhnik, Dominique Rey, Magali Provansal, Blandine Courbiere, Bruno Spire, Julien Mancini

Open Access Research article

Tumor-associated macrophages in oral premalignant lesions coexpress CD163 and STAT1 in a Th1-dominated microenvironment

Kazumasa Mori, Shigeki Haraguchi, Miki Hiori, Jun Shimada, Yoshihiro Ohmori

Open Access Research article

Texture analysis on MR images helps predicting non-response to NAC in breast cancer

N. Michoux, S. Van den Broeck, L. Lacoste, L. Fellah, C. Galant, M. Berlière, I. Leconte

Open Access Research article

Expression and role of oncogenic miRNA-224 in esophageal squamous cell carcinoma

Xiaoyan He, Zhimei Zhang, Ming Li, Shuo Li, Lihua Ren, Hong Zhu, Bin Xiao, Ruihua Shi

Open Access Research article

Magnolin inhibits cell migration and invasion by targeting the ERKs/RSK2 signaling pathway

Cheol-Jung Lee, Mee-Hyun Lee, Sun-Mi Yoo, Kyung-Il Choi, Ji-Hong Song, Jeong-Hoon Jang, Sei-Ryang Oh, Hyung-Won Ryu, Hye-Suk Lee, Young-Joon Surh, Yong-Yeon Cho

Open Access Research article

M1 and M2 macrophages derived from THP-1 cells differentially modulate the response of cancer cells to etoposide

Marie Genin, Francois Clement, Antoine Fattaccioli, Martine Raes, Carine Michiels

Open Access Research article

Variation in guideline adherence in non-Hodgkin’s lymphoma care: impact of patient and hospital characteristics

Jozette J.C. Stienen, Rosella P.M.G. Hermens, Lianne Wennekes, Saskia A.M. van de Schans, Richard W.M. van der Maazen, Helena M. Dekker, Janine Liefers, Johan H.J.M. van Krieken, Nicole M.A. Blijlevens, Petronella B. Ottevanger

Open Access Research article

In vitro engineering of human 3D chondrosarcoma: a preclinical model relevant for investigations of radiation quality impact

Dounia Houria Hamdi, Sofia Barbieri, François Chevalier, Jean-Emmanuel Groetz, Florence Legendre, Magali Demoor, Philippe Galera, Jean-Louis Lefaix, Yannick Saintigny

Open Access Research article

Moxifloxacin and ciprofloxacin induces S-phase arrest and augments apoptotic effects of cisplatin in human pancreatic cancer cells via ERK activation

Vikas Yadav, Pallavi Varshney, Sarwat Sultana, Jyoti Yadav, Neeru Saini

Open Access Research article

LC3B globular structures correlate with survival in esophageal adenocarcinoma

Shereen El-Mashed, Tracey R. O’Donovan, Elaine W. Kay, Ayat R. Abdallah, Mary-Clare Cathcart, Jacintha O’Sullivan, Anthony O’Grady, John Reynolds, Seamus O’Reilly, Gerald C. O’Sullivan, Sharon L. McKenna

Open Access Research article

Radical surgery versus standard surgery for primary cytoreduction of bulky stage IIIC and IV ovarian cancer: an observational study

Yulan Ren, Rong Jiang, Sheng Yin, Chao You, Dongli Liu, Xi Cheng, Jie Tang, Rongyu Zang

Open Access Research article

Il-6 signaling between ductal carcinoma in situ cells and carcinoma-associated fibroblasts mediates tumor cell growth and migration

Kingsley O. Osuala, Mansoureh Sameni, Seema Shah, Neha Aggarwal, Michelle L. Simonait, Omar E. Franco, Yan Hong, Simon W. Hayward, Fariba Behbod, Raymond R. Mattingly, Bonnie F. Sloane

Open Access Research article

Somatic drivers of B-ALL in a model of ETV6-RUNX1; Pax5 +/− leukemia

Louise van der Weyden, George Giotopoulos, Kim Wong, Alistair G. Rust, Carla Daniela Robles-Espinoza, Hikari Osaki, Brian J. Huntly, David J. Adams

Open Access Research article

Bcl2 inhibition of mitochondrial DNA repair

Maohua Xie, Paul W. Doetsch, Xingming Deng

Open Access Research article

Knowledge and attitudes regarding medical research studies among patients with breast cancer and gynecological diseases

Michael P. Lux, Thomas Hildebrandt, Sandra-Maria Knetzger, Michael G. Schrauder, Sebastian M. Jud, Alexander Hein, Claudia Rauh, Peter A. Fasching, Matthias W. Beckmann, Falk C. Thiel

Open Access Research article

Protein Kinase A-induced tamoxifen resistance is mediated by anchoring protein AKAP13

Cristiane Bentin Toaldo, Xanthippi Alexi, Karin Beelen, Marleen Kok, Michael Hauptmann, Maurice Jansen, Els Berns, Jacques Neefjes, Sabine Linn, Rob Michalides, Wilbert Zwart

Open Access Research article

Management of brain metastasis with magnetic resonance imaging and stereotactic irradiation attenuated benefits of prophylactic cranial irradiation in patients with limited-stage small cell lung cancer

Yuichi Ozawa, Minako Omae, Masato Fujii, Takashi Matsui, Masato Kato, Shinya Sagisaka, Kazuhiro Asada, Masato Karayama, Toshihiro Shirai, Kazumasa Yasuda, Yutaro Nakamura, Naoki Inui, Kazunari Yamada, Koshi Yokomura, Takafumi Suda

Open Access Research article

YKL-40 regulated epithelial-mesenchymal transition and migration/invasion enhancement in non-small cell lung cancer

Malvin Jefri, Yi-Ning Huang, Wen-Chien Huang, Chun-San Tai, Wen-Liang Chen

Open Access Research article

Essential medicines for breast cancer in low and middle income countries

Y. T. Bazargani, A. de Boer, J. H. M. Schellens, H. G. M. Leufkens, Aukje K. Mantel-Teeuwisse

Open Access Study protocol

Efficacy of a brief manualized intervention Managing Cancer and Living Meaningfully (CALM) adapted to German cancer care settings: study protocol for a randomized controlled trial

Katharina Scheffold, Rebecca Philipp, Dorit Engelmann, Frank Schulz-Kindermann, Christina Rosenberger, Karin Oechsle, Martin Härter, Karl Wegscheider, Florian Lordick, Chris Lo, Sarah Hales, Gary Rodin, Anja Mehnert

Open Access Study protocol

Early salpingectomy (TUbectomy) with delayed oophorectomy to improve quality of life as alternative for risk-reducing salpingo-oophorectomy in BRCA1/2 mutation carriers (TUBA study): a prospective non-randomised multicentre study

Marline G. Harmsen, Marieke Arts-de Jong, Nicoline Hoogerbrugge, Angela H. E. M. Maas, Judith B. Prins, Johan Bulten, Steven Teerenstra, Eddy M. M. Adang, Jurgen M. J. Piek, Helena C van Doorn, Marc van Beurden, Marian J. E. Mourits, Ronald P. Zweemer, Katja N. Gaarenstroom, Brigitte F. M. Slangen, M. Caroline Vos, Luc R. C. W. van Lonkhuijzen, Leon F. A. G. Massuger, Rosella P. M. G. Hermens, Joanne A. de Hullu

Open Access Research article

Neutrophil count is associated with survival in localized prostate cancer

Houda Bahig, Daniel Taussky, Guila Delouya, Amal Nadiri, Ariane Gagnon-Jacques, Paule Bodson-Clermont, Denis Soulieres

Open Access Research article

Berberine, a natural compound, suppresses Hedgehog signaling pathway activity and cancer growth

Juan Wang, Yuanqiu Peng, Yuan Liu, Jun Yang, Ning Ding, Wenfu Tan

Open Access Erratum

Erratum to: ComOn Coaching: study protocol of a randomized controlled trial to assess the effect of a varied number of coaching sessions on transfer into clinical practice following communication skills training

Marcelo Niglio de Figueiredo, Bärbel Rudolph, Carma L. Bylund, Tanja Goelz, Pia Heußner, Heribert Sattel, Kurt Fritzsche, Alexander Wuensch

Open Access Research article

Selective repression of RET proto-oncogene in medullary thyroid carcinoma by a natural alkaloid berberine

Vishnu Muthuraj Kumarasamy, Yoon-Joo Shin, John White, Daekyu Sun

Open Access Research article

A single-arm phase II trial of combined chemotherapy with S-1, oral leucovorin, and bevacizumab in heavily pre-treated patients with metastatic colorectal cancer

Kazuhisa Yamaguchi, Hiroya Taniguchi, Azusa Komori, Yukiya Narita, Sohei Nitta, Motoo Nomura, Shigenori Kadowaki, Daisuke Takahari, Takashi Ura, Masashi Andoh, Kei Muro, Keita Mori, Yoshinori Igarashi

Open Access Study protocol

PATHOS: a phase II/III trial of risk-stratified, reduced intensity adjuvant treatment in patients undergoing transoral surgery for Human papillomavirus (HPV) positive oropharyngeal cancer

Waheeda Owadally, Chris Hurt, Hayley Timmins, Emma Parsons, Sarah Townsend, Joanne Patterson, Katherine Hutcheson, Ned Powell, Matthew Beasley, Nachi Palaniappan, Max Robinson, Terence M. Jones, Mererid Evans

Open Access Research article

Over-expressing Akt in T cells to resist tumor immunosuppression and increase anti-tumor activity

Yanhong Wu, Zhenling Deng, Yishu Tang, Shuren Zhang, Yu-Qian Zhang

Open Access Research article

The transcription factor ERG increases expression of neurotransmitter receptors on prostate cancer cells

Haydn T. Kissick, Seung T. On, Laura K. Dunn, Martin G. Sanda, John M. Asara, Kathryn L. Pellegrini, Jonathan K. Noel, Mohamed S. Arredouani

Open Access Study protocol

Positive family history of colorectal cancer in a general practice setting [FRIDA.Frankfurt]: study protocol of a of a cross-sectional study

Andrea Siebenhofer, Jasper Plath, Maja Taubenroth, Susanne Singer, Marlene Hechtner, Anne Dahlhaus, Sandra Rauck, Sylvia Schulz-Rothe, Insa Koné, Ferdinand M. Gerlach

Open Access Research article

Framing overdiagnosis in breast screening: a qualitative study with Australian experts

Lisa M. Parker, Lucie Rychetnik, Stacy Carter

Open Access Research article

Cytokine serum levels during post-transplant adverse events in 61 pediatric patients after hematopoietic stem cell transplantation

Michaela Döring, Karin Melanie Cabanillas Stanchi, Markus Mezger, Annika Erbacher, Judith Feucht, Matthias Pfeiffer, Peter Lang, Rupert Handgretinger, Ingo Müller

Open Access Research article

Incomplete Dll4/Notch signaling inhibition promotes functional angiogenesis supporting the growth of skin papillomas

Dusan Djokovic, Alexandre Trindade, Joana Gigante, Mario Pinho, Adrian L. Harris, Antonio Duarte

Open Access Research article

Gamma tocotrienol targets tyrosine phosphatase SHP2 in mammospheres resulting in cell death through RAS/ERK pathway

Wenyi Gu, Indira Prasadam, Meihua Yu, Fengxia Zhang, Patrick Ling, Yin Xiao, Chengzhong Yu

Open Access Study protocol

The value of completion axillary treatment in sentinel node positive breast cancer patients undergoing a mastectomy: a Dutch randomized controlled multicentre trial (BOOG 2013-07)

L. M. van Roozendaal, J. HW de Wilt, T. van Dalen, J. A. van der Hage, L. JA Strobbe, L. J. Boersma, S. C. Linn, M. BI Lobbes, P. MP Poortmans, V. CG Tjan-Heijnen, K. KBT Van de Vijver, J. de Vries, A. H. Westenberg, A. GH Kessels, M. L. Smidt

Open Access Research article

Sulindac, 3,3’-diindolylmethane and curcumin reduce carcinogenesis in the Pirc rat, an Apc-driven model of colon carcinogenesis

Angelo Pietro Femia, Paulo Victoria Soares, Cristina Luceri, Maura Lodovici, Augusto Giannini, Giovanna Caderni

Open Access Research article

Patterns of diagnostic imaging and associated radiation exposure among long-term survivors of young adult cancer: a population-based cohort study

Corinne Daly, David R. Urbach, Thérèse A. Stukel, Paul C. Nathan, Wayne Deitel, Lawrence F. Paszat, Andrew S. Wilton, Nancy N. Baxter

Open Access Research article

Relationships between cancer pattern, country income and geographical region in Asia

Chirk Jenn Ng, Chin Hai Teo, Nurdiana Abdullah, Wei Phin Tan, Hui Meng Tan

Open Access Research article

Patient-derived heavy chain antibody targets cell surface HSP90 on breast tumors

Charan V. Devarakonda, Daniel Kita, Kathryn N. Phoenix, Kevin P. Claffey

Open Access Research article

Adjuvant therapy in the treatment of gallbladder cancer: a meta-analysis

Ning Ma, Hui Cheng, Baodong Qin, Renqian Zhong, Bin Wang

Open Access Case report

An infant with hyperalertness, hyperkinesis, and failure to thrive: a rare diencephalic syndrome due to hypothalamic anaplastic astrocytoma

Alessia Stival, Maurizio Lucchesi, Silvia Farina, Anna Maria Buccoliero, Francesca Castiglione, Lorenzo Genitori, Maurizio de Martino, Iacopo Sardi

Open Access Research article

Exploring research participation among cancer patients: analysis of a national survey and an in-depth interview study

Louise Mc Grath-Lone, Sophie Day, Claudia Schoenborn, Helen Ward

Open Access Research article

Neoadjuvant administration of Semliki Forest virus expressing interleukin-12 combined with attenuated Salmonella eradicates breast cancer metastasis and achieves long-term survival in immunocompetent mice

M. Gabriela Kramer, Martín Masner, Erkuden Casales, María Moreno, Cristian Smerdou, José A. Chabalgoity

Open Access Research article

A novel somatic mutation in ACD induces telomere lengthening and apoptosis resistance in leukemia cells

Jean-François Spinella, Pauline Cassart, Nicolas Garnier, Philippe Rousseau, Claire Drullion, Chantal Richer, Manon Ouimet, Virginie Saillour, Jasmine Healy, Chantal Autexier, Daniel Sinnett

Open Access Research article

The bifunctional autophagic flux by 2-deoxyglucose to control survival or growth of prostate cancer cells

Jeong Yong Jeon, Seung Won Kim, Ki Cheong Park, Mijin Yun

Open Access Research article

Boronic prodrug of 4-hydroxytamoxifen is more efficacious than tamoxifen with enhanced bioavailability independent of CYP2D6 status

Qiu Zhong, Changde Zhang, Qiang Zhang, Lucio Miele, Shilong Zheng, Guangdi Wang

Open Access Study protocol

Study protocol of the TRICOLORE trial: a randomized phase III study of oxaliplatin-based chemotherapy versus combination chemotherapy with S-1, irinotecan, and bevacizumab as first-line therapy for metastatic colorectal cancer

Yoshito Komatsu, Chikashi Ishioka, Ken Shimada, Yasuhide Yamada, Makio Gamoh, Atsushi Sato, Tatsuro Yamaguchi, Satoshi Yuki, Satoshi Morita, Shin Takahashi, Rei Goto, Minoru Kurihara

Open Access Research article

Aspirin and P2Y12 inhibition attenuate platelet-induced ovarian cancer cell invasion

Niamh M. Cooke, Cathy D. Spillane, Orla Sheils, John O’Leary, Dermot Kenny

Open Access Research article

DKK1 is a potential novel mediator of cisplatin-refractoriness in non-small cell lung cancer cell lines

Hogir Salim, Dali Zong, Petra Hååg, Metka Novak, Birgitta Mörk, Rolf Lewensohn, Lovisa Lundholm, Kristina Viktorsson

Open Access Research article

The Deleted in Liver Cancer 1 (Dlc1) tumor suppressor is haploinsufficient for mammary gland development and epithelial cell polarity

Pratima Basak, Rachelle Dillon, Heather Leslie, Afshin Raouf, Michael R. A. Mowat

Open Access Research article

S100A16 promotes differentiation and contributes to a less aggressive tumor phenotype in oral squamous cell carcinoma

Dipak Sapkota, Ove Bruland, Himalaya Parajuli, Tarig A. Osman, Muy-Teck Teh, Anne C. Johannessen, Daniela Elena Costea

Open Access Research article

Effects of cytochalasin congeners, microtubule-directed agents, and doxorubicin alone or in combination against human ovarian carcinoma cell lines in vitro

Matthew Trendowski, Timothy D. Christen, Christopher Acquafondata, Thomas P. Fondy

Open Access Research article

Optimizing the clinical utility of PCA3 to diagnose prostate cancer in initial prostate biopsy

Jose Rubio-Briones, Angel Borque, Luis M. Esteban, Juan Casanova, Antonio Fernandez-Serra, Luis Rubio, Irene Casanova-Salas, Gerardo Sanz, Jose Domínguez-Escrig, Argimiro Collado, Alvaro Gómez-Ferrer, Inmaculada Iborra, Miguel Ramírez-Backhaus, Francisco Martínez, Ana Calatrava, Jose A. Lopez-Guerrero

Open Access Research article

Chemotherapy induces Notch1-dependent MRP1 up-regulation, inhibition of which sensitizes breast cancer cells to chemotherapy

Baek Kim, Sam L. Stephen, Andrew M. Hanby, Kieran Horgan, Sarah L. Perry, Julie Richardson, Elizabeth A. Roundhill, Elizabeth M. A. Valleley, Eldo T. Verghese, Bethany J. Williams, James L. Thorne, Thomas A. Hughes

Open Access Research article

Size is an essential parameter in governing the UVB-protective efficacy of silver nanoparticles in human keratinocytes

Rohan Palanki, Sumit Arora, Nikhil Tyagi, Lilia Rusu, Ajay P. Singh, Srinivas Palanki, James E. Carter, Seema Singh

Open Access Research article

Mitogen-activated protein kinase activator with WD40 repeats (MAWD) and MAWD-binding protein induce cell differentiation in gastric cancer

Dongmei Li, Jun Zhang, Yu Xi, Lei Zhang, Wenmei Li, Jiantao Cui, Rui Xing, Yuanmin Pan, Zemin Pan, Feng Li, Youyong Lu

Open Access Research article

Coronin 2A (CRN5) expression is associated with colorectal adenoma-adenocarcinoma sequence and oncogenic signalling

Raphael H. Rastetter, Margit Blömacher, Uta Drebber, Marija Marko, Juliane Behrens, Roxana Solga, Sarah Hojeili, Kurchi Bhattacharya, Claudia M. Wunderlich, F. Thomas Wunderlich, Margarete Odenthal, Anja Ziemann, Ludwig Eichinger, Christoph S. Clemen

Open Access Technical advance

An improved sequencing-based strategy to estimate locus-specific DNA methylation

Giulia Brisotto, Alessandra di Gennaro, Valentina Damiano, Michela Armellin, Tiziana Perin, Roberta Maestro, Manuela Santarosa

Open Access Research article

Health related quality of life after oesophagectomy: elderly patients refer similar eating and swallowing difficulties than younger patients

Francesco Cavallin, Eleonora Pinto, Luca M. Saadeh, Rita Alfieri, Matteo Cagol, Carlo Castoro, Marco Scarpa

Open Access Research article

Secreted frizzled-related protein promotors are hypermethylated in cutaneous squamous carcinoma compared with normal epidermis

Junqin Liang, Xiaojing Kang, Yilinuer Halifu, Xuewen Zeng, Tianbo Jin, Mingxia Zhang, Dong Luo, Yuan Ding, Yunmin Zhou, Buwajier Yakeya, Dilinuer Abudu, Xiongming Pu

Open Access Research article

Effect of changes in treatment practice on survival for cervical cancer: results from a population-based study in Manitoba, Canada

Yoon-Jung Kang, Dianne L. O’Connell, Robert Lotocki, Erich V. Kliewer, David E. Goldsbury, Alain A. Demers, Karen Canfell

Open Access Research article

Angiogenesis-related protein expression in bevacizumab-treated metastatic colorectal cancer: NOTCH1 detrimental to overall survival

Tadeu Ferreira Paiva Jr., Victor Hugo Fonseca de Jesus, Raul Amorim Marques, Alexandre André Balieiro Anastácio da Costa, Mariana Petaccia de Macedo, Patricia Maria Peresi, Aline Damascena, Benedito Mauro Rossi, Maria Dirlei Begnami, Vladmir Cláudio Cordeiro de Lima

Open Access Research article

Expression profiling of O6 methylguanine-DNA-methyl transferase in prolactinomas: a correlative study of promoter methylation and pathological features in 136 cases

Xiao-Bing Jiang, Bin Hu, Dong-Sheng He, Zhi-Gang Mao, Xin Wang, Bing-Bing Song, Yong-Hong Zhu, Hai-Jun Wang

Open Access Research article

Essential role of miR-200c in regulating self-renewal of breast cancer stem cells and their counterparts of mammary epithelium

Zhong-Ming Feng, Jun Qiu, Xie-Wan Chen, Rong-Xia Liao, Xing-Yun Liao, Lu-Ping Zhang, Xu Chen, Yan Li, Zheng-Tang Chen, Jian-Guo Sun

Open Access Study protocol

OLIGOPELVIS – GETUG P07: a multicentre phase II trial of combined salvage radiotherapy and hormone therapy in oligometastatic pelvic node relapses of prostate cancer

Stephane Supiot, Emmanuel Rio, Valérie Pacteau, Marie-Hélène Mauboussin, Loïc Campion, François Pein

Open Access Research article

Aberrant activation of NF-κB signaling in mammary epithelium leads to abnormal growth and ductal carcinoma in situ

Whitney Barham, Lianyi Chen, Oleg Tikhomirov, Halina Onishko, Linda Gleaves, Thomas P. Stricker, Timothy S. Blackwell, Fiona E. Yull

Open Access Research article

Preoperative platelet-lymphocyte ratio is superior to neutrophil-lymphocyte ratio as a prognostic factor for soft-tissue sarcoma

Yi Que, Haibo Qiu, Yuanfang Li, Yongming Chen, Wei Xiao, Zhiwei Zhou, Xing Zhang

Open Access Research article

Functional analyses of ATM, ATR and Fanconi anemia proteins in lung carcinoma

Jan H. Beumer, Katherine Y. Fu, Bean N. Anyang, Jill M. Siegfried, Christopher J. Bakkenist

Open Access Research article

The effects of short-term fasting on tolerance to (neo) adjuvant chemotherapy in HER2-negative breast cancer patients: a randomized pilot study

Stefanie de Groot, Maaike PG Vreeswijk, Marij JP Welters, Gido Gravesteijn, Jan JWA Boei, Anouk Jochems, Daniel Houtsma, Hein Putter, Jacobus JM van der Hoeven, Johan WR Nortier, Hanno Pijl, Judith R Kroep

Open Access Study protocol

A randomized phase II study of weekly nab-paclitaxel plus gemcitabine or simplified LV5FU2 as first-line therapy in patients with metastatic pancreatic cancer: the AFUGEM GERCOR trial

Jean-Baptiste Bachet, Benoist Chibaudel, Franck Bonnetain, Pierre Validire, Pascal Hammel, Thierry André, Christophe Louvet

Open Access Research article

Evaluation of an assay for methylated BCAT1 and IKZF1 in plasma for detection of colorectal neoplasia

Susanne K. Pedersen, Erin L. Symonds, Rohan T. Baker, David H. Murray, Aidan McEvoy, Sascha C. Van Doorn, Marco W. Mundt, Stephen R. Cole, Geetha Gopalsamy, Dileep Mangira, Lawrence C. LaPointe, Evelien Dekker, Graeme P. Young

Open Access Research article

High expression of AGR2 in lung cancer is predictive of poor survival

Mohammed Alavi, Vei Mah, Erin L. Maresh, Lora Bagryanova, Steve Horvath, David Chia, Lee Goodglick, Alvin Y. Liu

Open Access Research article

Lipid peroxidation and glutathione peroxidase activity relationship in breast cancer depends on functional polymorphism of GPX1

Ewa Jablonska, Jolanta Gromadzinska, Beata Peplonska, Wojciech Fendler, Edyta Reszka, Magdalena B. Krol, Edyta Wieczorek, Agnieszka Bukowska, Peter Gresner, Michal Galicki, Oskar Zambrano Quispe, Zbigniew Morawiec, Wojciech Wasowicz

Open Access Research article

Tumour biology, metastatic sites and taxanes sensitivity as determinants of eribulin mesylate efficacy in breast cancer: results from the ERIBEX retrospective, international, multicenter study

Mélodie Dell’Ova, Eléonora De Maio, Séverine Guiu, Lise Roca, Florence Dalenc, Anna Durigova, Frédéric Pinguet, Khedidja Bekhtari, William Jacot, Stéphane Pouderoux

Open Access Research article

RECK is not an independent prognostic marker for breast cancer

Luciana R. Gomes, André Fujita, Joni D. Mott, Fernando A. Soares, Leticia Labriola, Mari C. Sogayar

Open Access Research article

Regulation of IL-8 gene expression in gliomas by microRNA miR-93

Enrica Fabbri, Eleonora Brognara, Giulia Montagner, Claudio Ghimenton, Albino Eccher, Cinzia Cantù, Susanna Khalil, Valentino Bezzerri, Lisa Provezza, Nicoletta Bianchi, Alessia Finotti, Monica Borgatti, Giuseppe Moretto, Marco Chilosi, Giulio Cabrini, Roberto Gambari

Open Access Research article

Agreement between MRI and pathologic breast tumor size after neoadjuvant chemotherapy, and comparison with alternative tests: individual patient data meta-analysis

Michael L. Marinovich, Petra Macaskill, Les Irwig, Francesco Sardanelli, Eleftherios Mamounas, Gunter von Minckwitz, Valentina Guarneri, Savannah C. Partridge, Frances C. Wright, Jae Hyuck Choi, Madhumita Bhattacharyya, Laura Martincich, Eren Yeh, Viviana Londero, Nehmat Houssami

Open Access Research article

Inhibition of IGF1-R overcomes IGFBP7-induced chemotherapy resistance in T-ALL

Isabelle Bartram, Ulrike Erben, Jutta Ortiz-Tanchez, Katja Blunert, Cornelia Schlee, Martin Neumann, Sandra Heesch, Claudia D. Baldus

Open Access Research article

The dog as a naturally-occurring model for insulin-like growth factor type 1 receptor-overexpressing breast cancer: an observational cohort study

Laetitia Jaillardon, Jérome Abadie, Tiffanie Godard, Mario Campone, Delphine Loussouarn, Brigitte Siliart, Frédérique Nguyen

Open Access Research article

Upregulation of MicroRNA-19b predicts good prognosis in patients with hepatocellular carcinoma presenting with vascular invasion or multifocal disease

Chung-Lin Hung, Chia-Shen Yen, Hung-Wen Tsai, Yu-Chieh Su, Chia-Jui Yen

Open Access Research article

40 years of progress in female cancer death risk: a Bayesian spatio-temporal mapping analysis in Switzerland

Christian Herrmann, Silvia Ess, Beat Thürlimann, Nicole Probst-Hensch, Penelope Vounatsou

Open Access Research article

Phase II clinical trial of sorafenib plus interferon-alpha treatment for patients with metastatic renal cell carcinoma in Japan

Masatoshi Eto, Yoshiaki Kawano, Yoshihiko Hirao, Koji Mita, Yoichi Arai, Taiji Tsukamoto, Katsuyoshi Hashine, Akio Matsubara, Tomoaki Fujioka, Go Kimura, Nobuo Shinohara, Katsunori Tatsugami, Shiro Hinotsu, Seiji Naito

Open Access Research article

Burkitt lymphoma beyond MYC translocation: N-MYC and DNA methyltransferases dysregulation

Giulia De Falco, Maria Raffaella Ambrosio, Fabio Fuligni, Anna Onnis, Cristiana Bellan, Bruno Jim Rocca, Mohsen Navari, Maryam Etebari, Lucia Mundo, Sara Gazaneo, Fabio Facchetti, Stefano A. Pileri, Lorenzo Leoncini, Pier Paolo Piccaluga

Open Access Research article

Assessment of DNA methylation profiling and copy number variation as indications of clonal relationship in ipsilateral and contralateral breast cancers to distinguish recurrent breast cancer from a second primary tumour

Katie T. Huang, Thomas Mikeska, Jason Li, Elena A. Takano, Ewan K A Millar, Peter H. Graham, Samantha E. Boyle, Ian G. Campbell, Terence P. Speed, Alexander Dobrovic, Stephen B. Fox

Open Access Research article

Evaluation of health benefits and harms of the breast cancer screening programme in the Basque Country using discrete event simulation

Arantzazu Arrospide, Montserrat Rue, Nicolien T. van Ravesteyn, Merce Comas, Nerea Larrañaga, Garbiñe Sarriugarte, Javier Mar

Open Access Research article

Enhancement of Cetuximab-Induced Radiosensitization by JAK-1 Inhibition

James A. Bonner, Hoa Q. Trummell, Andrew B. Bonner, Christopher D. Willey, Markus Bredel, Eddy S. Yang

Open Access Study protocol

Assessment and model guided cancer screening promotion by village doctors in China: a randomized controlled trial protocol

Rui Feng, Xingrong Shen, Jing Chai, Penglai Chen, Jing Cheng, Han Liang, Ting Zhao, Rui Sha, Kaichun Li, Debin Wang

Open Access Research article

Small ubiquitin-related modifier 2/3 interacts with p65 and stabilizes it in the cytoplasm in HBV-associated hepatocellular carcinoma

Jun Liu, Manqi Sha, Qianfeng Wang, Yong Ma, Xiaoping Geng, Yufeng Gao, Lijie Feng, Yujun Shen, Yuxian Shen

Open Access Research article

c-MET immunostaining in colorectal carcinoma is associated with local disease recurrence

Jaudah Al-Maghrabi, Eman Emam, Wafaey Gomaa, Moaath Saggaf, Abdelbaset Buhmeida, Mohammad Al-Qahtani, Mahmoud Al-Ahwal

Open Access Review

Head and neck cancer: metronomic chemotherapy

Francesca De Felice, Daniela Musio, Vincenzo Tombolini

Open Access Research article

Establishment of monoclonal HCC cell lines with organ site-specific tropisms

Jinliang Wan, Duo Wen, Lili Dong, Jun Tang, Dongli Liu, Yang Liu, Zhonghua Tao, Dongmei Gao, Huichuan Sun, Ya Cao, Jia Fan, Weizhong Wu

Open Access Research article

CA1 contributes to microcalcification and tumourigenesis in breast cancer

Yabing Zheng, Bing Xu, Yan Zhao, He Gu, Chang Li, Yao Wang, Xiaotian Chang

Open Access Research article

AKAP3 correlates with triple negative status and disease free survival in breast cancer

Rezvan Esmaeili, Keivan Majidzadeh-A, Leila Farahmand, Maryam Ghasemi, Malihe Salehi, Ali Reza Khoshdel

Open Access Research article

Hesperidin inhibits HeLa cell proliferation through apoptosis mediated by endoplasmic reticulum stress pathways and cell cycle arrest

Yaoxian Wang, Hui Yu, Jin Zhang, Jing Gao, Xin Ge, Ge Lou

Open Access Research article

Frequent down-regulation of ABC transporter genes in prostate cancer

Rita Demidenko, Deividas Razanauskas, Kristina Daniunaite, Juozas Rimantas Lazutka, Feliksas Jankevicius, Sonata Jarmalaite

Open Access Research article

PRIMA-1MET induces death in soft-tissue sarcomas cell independent of p53

Thomas Grellety, Audrey Laroche-Clary, Vanessa Chaire, Pauline Lagarde, Frédéric Chibon, Agnes Neuville, Antoine Italiano

Open Access Research article

NKTR-102 Efficacy versus irinotecan in a mouse model of brain metastases of breast cancer

Chris E. Adkins, Mohamed I. Nounou, Tanvirul Hye, Afroz S. Mohammad, Tori Terrell-Hall, Neel K. Mohan, Michael A. Eldon, Ute Hoch, Paul R. Lockman

Open Access Research article

Do Multidisciplinary Team (MDT) processes influence survival in patients with colorectal cancer? A population-based experience

Alastair Munro, Mhari Brown, Paddy Niblock, Robert Steele, Frank Carey

Open Access Research article

High PHLPP expression is associated with better prognosis in patients with resected lung adenocarcinoma

Dongqing Lv, Haihua Yang, Wei Wang, Youyou Xie, Wei Hu, Minhua Ye, Xiaofeng Chen

Open Access Research article

Representativeness of breast cancer cases in an integrated health care delivery system

Scarlett Lin Gomez, Salma Shariff-Marco, Julie Von Behren, Marilyn L. Kwan, Candyce H. Kroenke, Theresa H. M. Keegan, Peggy Reynolds, Lawrence H. Kushi

Open Access Research article

Postoperative complications affect early recurrence of hepatocellular carcinoma after curative resection

Yan-Ming Zhou, Xiao-Feng Zhang, Bin Li, Cheng-Jun Sui, Jia-Mei Yang

Open Access Research article

Prognostic influence of body mass index and body weight gain during adjuvant FOLFOX chemotherapy in Korean colorectal cancer patients

Dae-Won Lee, Sae-Won Han, Yongjun Cha, Kyung-Hun Lee, Tae-Yong Kim, Do-Youn Oh, Seock-Ah Im, Yung-Jue Bang, Ji Won Park, Seung-Bum Ryoo, Seung-Yong Jeong, Gyeong Hoon Kang, Kyu Joo Park, Tae-You Kim

Open Access Research article

Everolimus restrains the paracrine pro-osteoclast activity of breast cancer cells

Valeria Simone, Sabino Ciavarella, Oronzo Brunetti, Annalisa Savonarola, Mauro Cives, Marco Tucci, Giuseppina Opinto, Eugenio Maiorano, Franco Silvestris

Open Access Research article

Capecitabine in combination with either cisplatin or weekly paclitaxel as a first-line treatment for metastatic esophageal squamous cell carcinoma: a randomized phase II study

Su Jin Lee, Sungmin Kim, Moonjin Kim, Jeeyun Lee, Yeon Hee Park, Young-Hyuck Im, Se Hoon Park

Open Access Research article

Development of novel real-time PCR methodology for quantification of COL11A1 mRNA variants and evaluation in breast cancer tissue specimens

Makrina Karaglani, Ioannis Toumpoulis, Nikolaos Goutas, Nikoleta Poumpouridou, Dimitrios Vlachodimitropoulos, Spyridon Vasilaros, Ioannis Rizos, Christos Kroupis

Open Access Research article

Multicenter Phase II study of FOLFOX or biweekly XELOX and Erbitux (cetuximab) as first-line therapy in patients with wild-type KRAS/BRAF metastatic colorectal cancer: The FLEET study

Hitoshi Soda, Hiromichi Maeda, Junichi Hasegawa, Takao Takahashi, Shoichi Hazama, Mutsumi Fukunaga, Emiko Kono, Masahito Kotaka, Junichi Sakamoto, Naoki Nagata, Koji Oba, Hideyuki Mishima

Open Access Research article

Multiple primary malignancies involving lung cancer

Feng Li, Wen-Zhao Zhong, Fei-Yu Niu, Ning Zhao, Jin-Ji Yang, Hong-Hong Yan, Yi-Long Wu

Open Access Research article

Immunohistochemical subtypes predict the clinical outcome in high-risk node-negative breast cancer patients treated with adjuvant FEC regimen: results of a single-center retrospective study

S. Rahal, J M Boher, J M Extra, C. Tarpin, E. Charafe-Jauffret, E. Lambaudie, R. Sabatier, J. Thomassin-Piana, A. Tallet, M. Resbeut, G. Houvenaeghel, L. Laborde, F. Bertucci, P. Viens, A. Gonçalves

Open Access Research article

Differences in clinical importance of Bcl-2 in breast cancer according to hormone receptors status or adjuvant endocrine therapy

Naoko Honma, Rie Horii, Yoshinori Ito, Shigehira Saji, Mamoun Younes, Takuji Iwase, Futoshi Akiyama

Open Access Research article

Prognostic significance of proline, glutamic acid, leucine rich protein 1 (PELP1) in triple-negative breast cancer: a retrospective study on 129 cases

Yanzhi Zhang, Jiali Dai, Keely M. McNamara, Bing Bai, Mumu Shi, Monica S. M. Chan, Ming Liu, Hironobu Sasano, Xiuli Wang, Xiaolei Li, Lijuan Liu, Ying Ma, Shuwen Cao, Yanchun Xing, Baoshan Zhao, Yinli Song, Lin Wang

Open Access Research article

Efficacy of trabectedin in malignant solitary fibrous tumors: a retrospective analysis from the French Sarcoma Group

J. Khalifa, M. Ouali, L. Chaltiel, S. Le Guellec, A. Le Cesne, J-Y Blay, P. Cousin, L. Chaigneau, E. Bompas, S. Piperno-Neumann, B. Bui-Nguyen, M. Rios, J-P Delord, N. Penel, C. Chevreau

Open Access Research article

Critical role of CDK11p58 in human breast cancer growth and angiogenesis

Yayun Chi, Sheng Huang, Haojie Peng, Mengying Liu, Jun Zhao, Zhiming Shao, Jiong Wu

Open Access Research article

Estrogen-mediated inactivation of FOXO3a by the G protein-coupled estrogen receptor GPER

Erin Zekas, Eric R. Prossnitz

Open Access Research article

Serum CD26 levels in patients with gastric cancer: a novel potential diagnostic marker

Virginia Boccardi, Luigi Marano, Rosaria Rita Amalia Rossetti, Maria Rosaria Rizzo, Natale di Martino, Giuseppe Paolisso

Open Access Case report

Isolation of vaccinia JX594 from pustules following therapy for hepatocellular carcinoma

Che-Hsuan Kung, Shu-Chen Kuo, Te-Li Chen, Wen-Sung Weng

Open Access Research article

MiR-449a suppresses the epithelial-mesenchymal transition and metastasis of hepatocellular carcinoma by multiple targets

Shu-peng Chen, Bao-xin Liu, Jie Xu, Xiao-feng Pei, Yi-ji Liao, Feng Yuan, Fang Zheng

Open Access Research article

Improving immunological tumor microenvironment using electro-hyperthermia followed by dendritic cell immunotherapy

Yuk-Wah Tsang, Cheng-Chung Huang, Kai-Lin Yang, Mau-Shin Chi, Hsin-Chien Chiang, Yu-Shan Wang, Gabor Andocs, Andras Szasz, Wen-Tyng Li, Kwan-Hwa Chi

Open Access Research article

Investigation of the feasibility of elective irradiation to neck level Ib using intensity-modulated radiotherapy for patients with nasopharyngeal carcinoma: a retrospective analysis

Fan Zhang, Yi-Kan Cheng, Wen-Fei Li, Rui Guo, Lei Chen, Ying Sun, Yan-Ping Mao, Guan-Qun Zhou, Xu Liu, Li-Zhi Liu, Ai-Hua Lin, Ling-Long Tang, Jun Ma

Open Access Research article

Impact of a nutrition and physical activity intervention (ENRICH: Exercise and Nutrition Routine Improving Cancer Health) on health behaviors of cancer survivors and carers: a pragmatic randomized controlled trial

E. L. James, F. G. Stacey, K. Chapman, A. W. Boyes, T. Burrows, A. Girgis, G. Asprey, A. Bisquera, D. R. Lubans

Open Access Research article

Prior oral contraceptive use in ovarian cancer patients: assessing associations with overall and progression-free survival

Aminah Jatoi, Nathan R. Foster, Kimberly R. Kalli, Robert A. Vierkant, Zhiying Zhang, Melissa C. Larson, Brooke Fridley, Ellen L. Goode

Open Access Research article

Hypoxia alters the recruitment of tropomyosins into the actin stress fibres of neuroblastoma cells

Joshua J. Glass, Phoebe A. Phillips, Peter W. Gunning, Justine R. Stehn

Open Access Research article

Retreatment with anti-EGFR based therapies in metastatic colorectal cancer: impact of intervening time interval and prior anti-EGFR response

X. Liu, G. C. George, A. M. Tsimberidou, A. Naing, J. J. Wheler, S. Kopetz, S. Fu, S. A. Piha-Paul, C. Eng, G. S. Falchook, F. Janku, C. Garrett, D. Karp, R. Kurzrock, R. Zinner, K. Raghav, V. Subbiah, K. Hess, F. Meric-Bernstam, D. S. Hong, M. J. Overman

Open Access Research article

Gene expression and splicing alterations analyzed by high throughput RNA sequencing of chronic lymphocytic leukemia specimens

Wei Liao, Gwen Jordaan, Phillipp Nham, Ryan T. Phan, Matteo Pelegrini, Sanjai Sharma

Open Access Research article

Consolidation chemotherapy may improve survival for patients with locally advanced non-small-cell lung cancer receiving concurrent chemoradiotherapy - retrospective analysis of 203 cases

Lipin Liu, Nan Bi, Zhe Ji, Junling Li, Jingbo Wang, Xiaozhen Wang, Zhouguang Hui, Jima Lv, Jun Liang, Zongmei Zhou, Yan Wang, Weibo Yin, Luhua Wang

Open Access Research article

Oncolytic adenovirus targeting cyclin E overexpression repressed tumor growth in syngeneic immunocompetent mice

Pei-Hsin Cheng, Xiao-Mei Rao, Stephen L. Wechman, Xiao-Feng Li, Kelly M. McMasters, Heshan Sam Zhou

Open Access Research article

The existence of Th22, pure Th17 and Th1 cells in CIN and Cervical Cancer along with their frequency variation in different stages of cervical cancer

Wenjing Zhang, Xinli Tian, Fidia Mumtahana, Jun Jiao, Teng Zhang, Kimiko Della Croce, Daoxin Ma, Beihua Kong, Baoxia Cui

Open Access Research article

Construction of possible integrated predictive index based on EGFR and ANXA3 polymorphisms for chemotherapy response in fluoropyrimidine-treated Japanese gastric cancer patients using a bioinformatic method

Hiro Takahashi, Nahoko Kaniwa, Yoshiro Saito, Kimie Sai, Tetsuya Hamaguchi, Kuniaki Shirao, Yasuhiro Shimada, Yasuhiro Matsumura, Atsushi Ohtsu, Takayuki Yoshino, Toshihiko Doi, Anna Takahashi, Yoko Odaka, Misuzu Okuyama, Jun-ichi Sawada, Hiromi Sakamoto, Teruhiko Yoshida

Open Access Research article

No evidence for a decreased risk of thyroid cancer in association with use of metformin or other antidiabetic drugs: a case-control study

Claudia Becker, Susan S. Jick, Christoph R. Meier, Michael Bodmer

Open Access Research article

Metabolic syndrome and the risk of urothelial carcinoma of the bladder: a case-control study

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P38 MAPK expression and activation predicts failure of response to CHOP in patients with Diffuse Large B-Cell Lymphoma

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Open Access Case report

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Up-regulation of HER2 by gemcitabine enhances the antitumor effect of combined gemcitabine and trastuzumab emtansine treatment on pancreatic ductal adenocarcinoma cells

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Open Access Case report

Status epilepticus associated with platinum chemotherapy in a patient with cervical cancer: a case report

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Open Access Research article

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Open Access Research article

Expression of Oct3/4 and Nanog in the head and neck squamous carcinoma cells and its clinical implications for delayed neck metastasis in stage I/II oral tongue squamous cell carcinoma

Noboru Habu, Yorihisa Imanishi, Kaori Kameyama, Masayuki Shimoda, Yutaka Tokumaru, Koji Sakamoto, Ryoichi Fujii, Seiji Shigetomi, Kuninori Otsuka, Yoichiro Sato, Yoshihiro Watanabe, Hiroyuki Ozawa, Toshiki Tomita, Masato Fujii, Kaoru Ogawa

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Open Access Case report

Relapsing pneumonitis due to two distinct inhibitors of the MAPK/ERK pathway: report of a case

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Open Access Research article

Coffee consumption and the risk of gastric cancer: a meta-analysis of prospective cohort studies

Liqing Li, Yong Gan, Chunmei Wu, Xianguo Qu, Gang Sun, Zuxun Lu

Open Access Research article

The adherence paradox: guideline deviations contribute to the increased 5-year survival of breast cancer patients

Christian O. Jacke, Ute S. Albert, Matthias Kalder

Open Access Research article

A case–control study of sporadic retinoblastoma in relation to maternal health conditions and reproductive factors: a report from the Children’s Oncology group

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Open Access Research article

DNA hypermethylation and decreased mRNA expression of MAL, PRIMA1, PTGDR and SFRP1 in colorectal adenoma and cancer

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Genomic profile predicts the efficacy of neoadjuvant chemotherapy for cervical cancer patients

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Open Access Research article

Feasibility study of docetaxel plus bevacizumab as first line therapy for elderly patients with advanced non-small-cell lung cancer: Thoracic Oncology Research Group (TORG) 1014

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The role of communication in breast cancer screening: a qualitative study with Australian experts

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Open Access Research article

Heparan sulfate proteoglycans undergo differential expression alterations in right sided colorectal cancer, depending on their metastatic character

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Open Access Research article

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Open Access Research article

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Open Access Research article

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Open Access Research article

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Open Access Research article

Correlation between apparent diffusion coefficients and HER2 status in gastric cancers: pilot study

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Open Access Research article

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Open Access Research article

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Open Access Research article

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Open Access Research article

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Open Access Research article

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Open Access Research article

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Open Access Research article

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Open Access Research article

Association between shift work and the risk of death from biliary tract cancer in Japanese men

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Evaluation of the prognostic impact of postoperative adjuvant radiotherapy on head and neck mucosal melanoma: a meta-analysis

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Open Access Research article

Does anti-p53 antibody status predict for clinical outcomes in metastatic colorectal cancer patients treated with fluoropyrimidine, oxaliplatin, plus bevacizumab as first-line chemotherapy?

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Open Access Research article

Regulation of cellular sphingosine-1-phosphate by sphingosine kinase 1 and sphingosine-1-phopshate lyase determines chemotherapy resistance in gastroesophageal cancer

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Open Access Study protocol

Bevacizumab and Combination Chemotherapy in rectal cancer Until Surgery (BACCHUS): a phase II, multicentre, open-label, randomised study of neoadjuvant chemotherapy alone in patients with high-risk cancer of the rectum

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Open Access Study protocol

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H. J. G. Abrahams, M. F. M. Gielissen, M. M. Goedendorp, T. Berends, M. E. W. J. Peters, H. Poort, C. A. H. H. V. M. Verhagen, H. Knoop

Open Access Research article

The prognostic value of CXC-chemokine receptor 2 (CXCR2) in gastric cancer patients

Zhenglin Wang, Hao Liu, Zhenbin Shen, Xuefei Wang, Heng Zhang, Jing Qin, Jiejie Xu, Yihong Sun, Xinyu Qin

Open Access Research article

Molecular mechanism of anti-cancer activity of phycocyanin in triple-negative breast cancer cells

Mathangi Ravi, Shilpa Tentu, Ganga Baskar, Surabhi Rohan Prasad, Swetha Raghavan, Prajisha Jayaprakash, Jeyaraman Jeyakanthan, Suresh K Rayala, Ganesh Venkatraman

Open Access Research article

Cross platform analysis of methylation, miRNA and stem cell gene expression data in germ cell tumors highlights characteristic differences by tumor histology

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Open Access Research article

The NF-κB p65 and p50 homodimer cooperate with IRF8 to activate iNOS transcription

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Open Access Research article

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Deborah Saltman, Arie Barlev, Divyagiri Seshagiri, Ioannis Katsoulis, Vincent Lin, Beth Barber

Open Access Study protocol

Colorectal liver metastatic disease: efficacy of irreversible electroporation—a single-arm phase II clinical trial (COLDFIRE-2 trial)

Hester J. Scheffer, Laurien G P H Vroomen, Karin Nielsen, Aukje A J M van Tilborg, Emile F I Comans, Cornelis van Kuijk, Bram B. van der Meijs, Janneke van den Bergh, Petrousjka M P van den Tol, Martijn R. Meijerink

Open Access Research article

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Open Access Research article

Small nucleolar RNA U91 is a new internal control for accurate microRNAs quantification in pancreatic cancer

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Open Access Research article

Association between praziquantel treatment and cholangiocarcinoma: a hospital-based matched case–control study

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Open Access Research article

TrkA is amplified in malignant melanoma patients and induces an anti-proliferative response in cell lines

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Open Access Research article

Transcriptional profiles of pilocytic astrocytoma are related to their three different locations, but not to radiological tumor features

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Open Access Research article

Clinical detection and categorization of uncommon and concomitant mutations involving BRAF

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Open Access Research article

KIT exon 10 variant (c.1621 A > C) single nucleotide polymorphism as predictor of GIST patient outcome

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Open Access Research article

Ambulatory Medical Assistance - After Cancer (AMA-AC): A model for an early trajectory survivorship survey of lymphoma patients treated with anthracycline-based chemotherapy

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Open Access Research article

Prognostic significance of Epstein-Barr virus infection in gastric cancer: a meta-analysis

Xuechao Liu, Jianjun Liu, Haibo Qiu, Pengfei Kong, Shangxiang Chen, Wei Li, Youqing Zhan, Yuanfang Li, Yingbo Chen, Zhiwei Zhou, Dazhi Xu, Xiaowei Sun

Open Access Research article

The inflammatory milieu within the pancreatic cancer microenvironment correlates with clinicopathologic parameters, chemoresistance and survival

Daniel Delitto, Brian S. Black, Heather L. Sorenson, Andrea E. Knowlton, Ryan M. Thomas, George A. Sarosi, Lyle L. Moldawer, Kevin E. Behrns, Chen Liu, Thomas J. George, Jose G. Trevino, Shannon M. Wallet, Steven J. Hughes

Open Access Research article

Cancer-testis antigen cyclin A1 is broadly expressed in ovarian cancer and is associated with prolonged time to tumor progression after platinum-based therapy

Ruza Arsenic, Elena Ilona Braicu, Anne Letsch, Manfred Dietel, Jalid Sehouli, Ulrich Keilholz, Sebastian Ochsenreither

Open Access Research article

Putative stem cell markers in cervical squamous cell carcinoma are correlated with poor clinical outcome

Teng Hou, Weijing Zhang, Chongjie Tong, Gallina Kazobinka, Xin Huang, Yongwen Huang, Yanna Zhang

Open Access Research article

Capecitabine and oxaliplatin combined with bevacizumab are feasible for treating selected Japanese patients at least 75 years of age with metastatic colorectal cancer

Yoshinori Munemoto, Mitsuro Kanda, Keiichiro Ishibashi, Taishi Hata, Michiya Kobayashi, Junichi Hasegawa, Mutsumi Fukunaga, Akinori Takagane, Toshio Otsuji, Yasuhiro Miyake, Michitaka Nagase, Junichi Sakamoto, Masaki Matsuoka, Koji Oba, Hideyuki Mishima

Open Access Research article

Patterns of resource utilization and cost for postmenopausal women with hormone-receptor–positive, human epidermal growth factor receptor-2–negative advanced breast cancer in Europe

Guy Jerusalem, Patrick Neven, Nina Marinsek, Jie Zhang, Ravi Degun, Giancarlo Benelli, Stephen Saletan, Jean-François Ricci, Fabrice Andre

Open Access Case report

Hypercalcemia in metastatic GIST caused by systemic elevated calcitriol: a case report and review of the literature

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Open Access Research article

Demethylation of HIN-1 reverses paclitaxel-resistance of ovarian clear cell carcinoma through the AKT-mTOR signaling pathway

Chih-Ming Ho, Chi-Jung Huang, Shih-Hung Huang, Shwu-Fen Chang, Wen-Fang Cheng

Open Access Research article

Prognostic significance of macrophage invasion in hilar cholangiocarcinoma

Georgi Atanasov, Hans-Michael Hau, Corinna Dietel, Christian Benzing, Felix Krenzien, Andreas Brandl, Georg Wiltberger, Ivan Matia, Isabel Prager, Katrin Schierle, Simon C. Robson, Anja Reutzel-Selke, Johann Pratschke, Moritz Schmelzle, Sven Jonas

Open Access Research article

The unique transcriptional response produced by concurrent estrogen and progesterone treatment in breast cancer cells results in upregulation of growth factor pathways and switching from a Luminal A to a Basal-like subtype

Eleanor F. Need, Luke A. Selth, Andrew P. Trotta, Damien A. Leach, Lauren Giorgio, Melissa A. O’Loughlin, Eric Smith, Peter G. Gill, Wendy V. Ingman, J. Dinny Graham, Grant Buchanan

Open Access Debate

Can Peto’s paradox be used as the null hypothesis to identify the role of evolution in natural resistance to cancer? A critical review

Hugo Ducasse, Beata Ujvari, Eric Solary, Marion Vittecoq, Audrey Arnal, Florence Bernex, Nelly Pirot, Dorothée Misse, François Bonhomme, François Renaud, Frédéric Thomas, Benjamin Roche

Open Access Research article

Tumorigenic hybrids between mesenchymal stem cells and gastric cancer cells enhanced cancer proliferation, migration and stemness

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Open Access Research article

Prognostic significance of Traf2- and Nck- interacting kinase (TNIK) in colorectal cancer

Hidenori Takahashi, Toshiaki Ishikawa, Megumi Ishiguro, Satoshi Okazaki, Kaoru Mogushi, Hirotoshi Kobayashi, Satoru Iida, Hiroshi Mizushima, Hiroshi Tanaka, Hiroyuki Uetake, Kenichi Sugihara

Open Access Research article

Inhibition of autophagy exerts anti-colon cancer effects via apoptosis induced by p53 activation and ER stress

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Open Access Research article

Circulating tumor cells (CTC) and KRAS mutant circulating free DNA (cfDNA) detection in peripheral blood as biomarkers in patients diagnosed with exocrine pancreatic cancer

Julie Earl, Sandra Garcia-Nieto, Jose Carlos Martinez-Avila, José Montans, Alfonso Sanjuanbenito, Mercedes Rodríguez-Garrote, Eduardo Lisa, Elena Mendía, Eduardo Lobo, Núria Malats, Alfredo Carrato, Carmen Guillen-Ponce

Open Access Research article

Non-participation in breast cancer screening for women with chronic diseases and multimorbidity: a population-based cohort study

L. F. Jensen, A. F. Pedersen, B. Andersen, M. Vestergaard, P. Vedsted

Open Access Research article

The postoperative patient-reported quality of recovery in colorectal cancer patients under enhanced recovery after surgery using QoR-40

Dai Shida, Kotaro Wakamatsu, Yuu Tanaka, Atsushi Yoshimura, Masahiko Kawaguchi, Sachio Miyamoto, Kyoko Tagawa

Open Access Research article

E2-EPF UCP regulates stability and functions of missense mutant pVHL via ubiquitin mediated proteolysis

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Open Access Research article

Lysine-specific demethylase 5C promotes hepatocellular carcinoma cell invasion through inhibition BMP7 expression

Xuening Ji, Shi Jin, Xiaotong Qu, Kejun Li, Hongjiang Wang, Hui He, Fuchao Guo, Lei Dong

Open Access Research article

Phase II trial of selective internal radiation therapy and systemic chemotherapy for liver-predominant metastases from pancreatic adenocarcinoma

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Open Access Research article

Gene expression profiling analysis of CRTC1-MAML2 fusion oncogene-induced transcriptional program in human mucoepidermoid carcinoma cells

Jie Chen, Jian-Liang Li, Zirong Chen, James D. Griffin, Lizi Wu

Open Access Research article

Elevated expression of HSP90 and the antitumor effect of an HSP90 inhibitor via inactivation of the Akt/mTOR pathway in undifferentiated pleomorphic sarcoma

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Open Access Research article

Hypoxia biomarkers in squamous cell carcinoma of the uterine cervix

Christine Ellingsen, Lise Mari K. Andersen, Kanthi Galappathi, Einar K. Rofstad

Open Access Hypothesis

Current opinion on the role of testosterone in the development of prostate cancer: a dynamic model

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Open Access Research article

Benzofuroxan derivatives N-Br and N-I induce intrinsic apoptosis in melanoma cells by regulating AKT/BIM signaling and display anti metastatic activity in vivo

C. F. Farias, M. H. Massaoka, N. Girola, R. A. Azevedo, A. K. Ferreira, S. D. Jorge, L. C. Tavares, C. R. Figueiredo, L. R. Travassos

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Prediction of response to anti-EGFR antibody-based therapies by multigene sequencing in colorectal cancer patients

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Prognostic value of inhibitors of apoptosis proteins (IAPs) and caspases in prostate cancer: caspase-3 forms and XIAP predict biochemical progression after radical prostatectomy

Gonzalo Rodríguez-Berriguete, Norelia Torrealba, Miguel Angel Ortega, Pilar Martínez-Onsurbe, Gabriel Olmedilla, Ricardo Paniagua, Manuel Guil-Cid, Benito Fraile, Mar Royuela

Open Access Research article

Propensity-matched analysis of three different chemotherapy sequences in patients with locoregionally advanced nasopharyngeal carcinoma treated using intensity-modulated radiotherapy

Wen-Fei Li, Ying-Qin Li, Lei Chen, Yuan Zhang, Rui Guo, Fan Zhang, Hao Peng, Ying Sun, Jun Ma

Open Access Research article

Stem cell protein Piwil1 endowed endometrial cancer cells with stem-like properties via inducing epithelial-mesenchymal transition

Zheng Chen, Qi Che, Xiaoying He, Fangyuan Wang, Huihui Wang, Minjiao Zhu, Jing Sun, Xiaoping Wan

Open Access Research article

Long-term results of chemoradiotherapy for stage II-III thoracic esophageal cancer in a single institution after 2000 -with a focus on comparison of three protocols-

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Open Access Research article

Incarvine C suppresses proliferation and vasculogenic mimicry of hepatocellular carcinoma cells via targeting ROCK inhibition

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Open Access Research article

The importance of extranodal extension in penile cancer: a meta-analysis

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Open Access Research article

Exploring DNA methylation changes in promoter, intragenic, and intergenic regions as early and late events in breast cancer formation

Garth H. Rauscher, Jacob K. Kresovich, Matthew Poulin, Liying Yan, Virgilia Macias, Abeer M. Mahmoud, Umaima Al-Alem, Andre Kajdacsy-Balla, Elizabeth L. Wiley, Debra Tonetti, Melanie Ehrlich

Open Access Research article

Suppression of Homologous Recombination by insulin-like growth factor-1 inhibition sensitizes cancer cells to PARP inhibitors

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Open Access Research article

microRNA-145 promotes differentiation in human urothelial carcinoma through down-regulation of syndecan-1

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SOX4 expression is associated with treatment failure and chemoradioresistance in oral squamous cell carcinoma

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Withdrawal of anticancer therapy in advanced disease: a systematic literature review

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Open Access Study protocol

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Open Access Study protocol

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Open Access Case report

Pharmacokinetics and safety of cyclophosphamide and docetaxel in a hemodialysis patient with early stage breast cancer: a case report

Liu Yang, Xiao-chen Zhang, Su-feng Yu, Hua-Qing Zhu, Ai-ping Hu, Jian Chen, Peng Shen

Open Access Research article

The combination of four molecular markers improves thyroid cancer cytologic diagnosis and patient management

Federica Panebianco, Chiara Mazzanti, Sara Tomei, Paolo Aretini, Sara Franceschi, Francesca Lessi, Giancarlo Di Coscio, Generoso Bevilacqua, Ivo Marchetti

Open Access Research article

Pan-Bcl-2 inhibitor Obatoclax is a potent late stage autophagy inhibitor in colorectal cancer cells independent of canonical autophagy signaling

Bruno Christian Koehler, Adam Jassowicz, Anna-Lena Scherr, Stephan Lorenz, Praveen Radhakrishnan, Nicole Kautz, Christin Elssner, Johanna Weiss, Dirk Jaeger, Martin Schneider, Henning Schulze-Bergkamen

Open Access Research article

Aberrant GSTP1 promoter methylation is associated with increased risk and advanced stage of breast cancer: a meta-analysis of 19 case-control studies

Cheng Fang, Xue-Mei Wei, Xian-Tao Zeng, Fu-Bing Wang, Hong Weng, Xinghua Long

Open Access Research article

Socioeconomic disparities in breast cancer incidence and survival among parous women: findings from a population-based cohort, 1964–2008

Mandy Goldberg, Ronit Calderon-Margalit, Ora Paltiel, Wiessam Abu Ahmad, Yechiel Friedlander, Susan Harlap, Orly Manor

Open Access Research article

Macrophage traits in cancer cells are induced by macrophage-cancer cell fusion and cannot be explained by cellular interaction

Ivan Shabo, Kristine Midtbö, Henrik Andersson, Emma Åkerlund, Hans Olsson, Pia Wegman, Cecilia Gunnarsson, Annelie Lindström

Open Access Study protocol

CoCStom trial: study protocol for a randomised trial comparing completeness of adjuvant chemotherapy after early versus late diverting stoma closure in low anterior resection for rectal cancer

Flavius Sandra-Petrescu, Florian Herrle, Axel Hinke, Inga Rossion, Heiko Suelberg, Stefan Post, Ralf-Dieter Hofheinz, Peter Kienle

Open Access Research article

Gastric cancer progression associated with local humoral immune responses

López-Vidal Yolanda, Ponce-de-León Sergio, Esquivel-Solís Hugo, Amieva-Fernández Rosa Isabel, Barreto-Zúñiga Rafael, Torre-Delgadillo Aldo, Castillo-Rojas Gonzalo

Open Access Research article

Co-expression of parathyroid hormone related protein and TGF-beta in breast cancer predicts poor survival outcome

Cheng Xu, Zhengyuan Wang, Rongrong Cui, Hongyu He, Xiaoyan Lin, Yuan Sheng, Hongwei Zhang

Open Access Case report

Somatic and germline analyses of a long term melanoma survivor with a recurrent brain metastasis

Sarah Weiss, Farbod Darvishian, Jyothi Tadepalli, Richard Shapiro, John Golfinos, Anna Pavlick, David Polsky, Tomas Kirchhoff, Iman Osman

Open Access Research article

Laparoscopy versus laparotomy for the management of early stage cervical cancer

Yan-zhou Wang, Li Deng, Hui-cheng Xu, Yao Zhang, Zhi-qing Liang

Open Access Research article

Identification of surrogate endpoints in patients with locoregionally advanced nasopharyngeal carcinoma receiving neoadjuvant chemotherapy plus concurrent chemoradiotherapy versus concurrent chemoradiotherapy alone

Yu-Pei Chen, Wen-Na Zhang, Ling-Long Tang, Yan-Ping Mao, Xu Liu, Lei Chen, Guan-Qun Zhou, Hai-Qiang Mai, Jian-Yong Shao, Wei-Hua Jia, Tie-Bang Kang, Mu-Sheng Zeng, Ying Sun, Jun Ma

Open Access Research article

Gonadotropin-mediated chemoresistance: Delineation of molecular pathways and targets

Suchismita Sahoo, Poonam Singh, Beneeta Kalha, Om Singh, Rahul Pal

Open Access Research article

Evaluation of transabdominal ultrasound after oral administration of an echoic cellulose-based gastric ultrasound contrast agent for gastric cancer

Zhijun Liu, Jintao Guo, Shupeng Wang, Ying Zhao, Jing Li, Weidong Ren, Shaoshan Tang, Limei Xie, Ying Huang, Siyu Sun, Liping Huang

Open Access Research article

TSG101, a tumor susceptibility gene, bidirectionally modulates cell invasion through regulating MMP-9 mRNA expression

Xu Bin Sai, Tomohiko Makiyama, Hiroshi Sakane, Yukimi Horii, Hideyuki Hiraishi, Hiromichi Shirataki

Open Access Research article

The effect of direct access to CT scan in early lung cancer detection: an unblinded, cluster-randomised trial

Louise Mahncke Guldbrandt, Morten Fenger-Grøn, Torben Riis Rasmussen, Finn Rasmussen, Peter Meldgaard, Peter Vedsted

Open Access Research article

Understanding of BRCA VUS genetic results by breast cancer specialists

B. K. Eccles, E. Copson, T. Maishman, J. E. Abraham, D. M. Eccles

Open Access Research article

Under-treatment of elderly patients with ovarian cancer: a population based study

Elisabeth Fourcadier, Brigitte Trétarre, Claudine Gras-Aygon, Fiona Ecarnot, Jean-Pierre Daurès, Faïza Bessaoud

Open Access Research article

Psychometric properties of the Chinese version of the fatigue scale-adolescent

Ka Yan Ho, William H. C. Li, Ka Wai Katherine Lam, S. Y. Chui, Chi-Fung Godfrey Chan

Open Access Research article

Sorafenib suppresses the epithelial-mesenchymal transition of hepatocellular carcinoma cells after insufficient radiofrequency ablation

Shuying Dong, Jian Kong, Fandong Kong, Jinge Kong, Jun Gao, Liang Ji, Bing Pan, Lian Chen, Lemin Zheng, Wenbing Sun

Open Access Research article

Intra-tumor heterogeneity in TP53 null High Grade Serous Ovarian Carcinoma progression

Alba Mota, Juan Carlos Triviño, Alejandro Rojo-Sebastian, Ángel Martínez-Ramírez, Luis Chiva, Antonio González-Martín, Juan F. Garcia, Pablo Garcia-Sanz, Gema Moreno-Bueno

Open Access Research article

KPT-330, a potent and selective exportin-1 (XPO-1) inhibitor, shows antitumor effects modulating the expression of cyclin D1 and survivin in prostate cancer models

Giovanni Luca Gravina, Andrea Mancini, Patrizia Sanita, Flora Vitale, Francesco Marampon, Luca Ventura, Yosef Landesman, Dilara McCauley, Michael Kauffman, Sharon Shacham, Claudio Festuccia

Open Access Research article

Difficulty of predicting the presence of lymph node metastases in patients with clinical early stage gastric cancer: a case control study

Masatoshi Nakagawa, Yoon Young Choi, Ji Yeong An, Hyunsoo Chung, Sang Hyuk Seo, Hyun Beak Shin, Hui-Jae Bang, Shuangxi Li, Hyung-Il Kim, Jae-Ho Cheong, Woo Jin Hyung, Sung Hoon Noh

Open Access Research article

CYP1B1 promotes tumorigenesis via altered expression of CDC20 and DAPK1 genes in renal cell carcinoma

Yozo Mitsui, Inik Chang, Shinichiro Fukuhara, Miho Hiraki, Naoko Arichi, Hiroaki Yasumoto, Hiroshi Hirata, Soichiro Yamamura, Varahram Shahryari, Guoren Deng, Darryn K. Wong, Shahana Majid, Hiroaki Shiina, Rajvir Dahiya, Yuichiro Tanaka

Open Access Research article

Immunohistochemical evaluation of ROCK activation in invasive breast cancer

Chih-Yi Hsu, Zee-Fen Chang, Hsiao-Hui Lee

Open Access Research article

A novel human leiomyoma tissue derived matrix for cell culture studies

Tuula Salo, Meeri Sutinen, Ehsanul Hoque Apu, Elias Sundquist, Nilva K. Cervigne, Carine Ervolino de Oliveira, Saad Ullah Akram, Steffen Ohlmeier, Fumi Suomi, Lauri Eklund, Pirjo Juusela, Pirjo Åström, Carolina Cavalcante Bitu, Markku Santala, Kalle Savolainen, Johanna Korvala, Adriana Franco Paes Leme, Ricardo D. Coletta

Open Access Research article

Partial PTEN deletion is linked to poor prognosis in breast cancer

P. Lebok, V. Kopperschmidt, M. Kluth, C. Hube-Magg, C. Özden, Taskin B., K. Hussein, A. Mittenzwei, A. Lebeau, I. Witzel, L. Wölber, S. Mahner, F. Jänicke, S. Geist, P. Paluchowski, C. Wilke, U. Heilenkötter, Ronald Simon, Guido Sauter, L. Terracciano, R. Krech, A. von d. Assen, V. Müller, E. Burandt

Open Access Research article

Methylation status of COX-2 in blood leukocyte DNA and risk of gastric cancer in a high-risk Chinese population

Hui-juan Su, Yang Zhang, Lian Zhang, Jun-ling Ma, Ji-You Li, Kai-feng Pan, Wei-cheng You

Open Access Research article

A polymorphism in the base excision repair gene PARP2 is associated with differential prognosis by chemotherapy among postmenopausal breast cancer patients

Petra Seibold, Peter Schmezer, Sabine Behrens, Kyriaki Michailidou, Manjeet K. Bolla, Qin Wang, Dieter Flesch-Janys, Heli Nevanlinna, Rainer Fagerholm, Kristiina Aittomäki, Carl Blomqvist, Sara Margolin, Arto Mannermaa, Vesa Kataja, Veli-Matti Kosma, Jaana M. Hartikainen, Diether Lambrechts, Hans Wildiers, Vessela Kristensen, Grethe Grenaker Alnæs, Silje Nord, Anne-Lise Borresen-Dale, Maartje J. Hooning, Antoinette Hollestelle, Agnes Jager, Caroline Seynaeve, Jingmei Li, Jianjun Liu, Keith Humphreys, Alison M. Dunning, Valerie Rhenius, Mitul Shah, Maria Kabisch, Diana Torres, Hans-Ulrich Ulmer, Ute Hamann, Joellen M. Schildkraut, Kristen S. Purrington, Fergus J. Couch, Per Hall, Paul Pharoah, Doug F. Easton, Marjanka K. Schmidt, Jenny Chang-Claude, Odilia Popanda

Open Access Research article

The impact of the cumulative dose of cisplatin during concurrent chemoradiotherapy on the clinical outcomes of patients with advanced-stage nasopharyngeal carcinoma in an era of intensity-modulated radiotherapy

Shan-Shan Guo, Lin-Quan Tang, Lu Zhang, Qiu-Yan Chen, Li-Ting Liu, Ling Guo, Hao-Yuan Mo, Dong-Hua Luo, Pei-Yu Huang, Yan-Qun Xiang, Rui Sun, Ming-Yuan Chen, Lin Wang, Xing Lv, Chong Zhao, Xiang Guo, Ka-Jia Cao, Chao-Nan Qian, Mu-Sheng Zeng, Jin-Xin Bei, Ming-Huang Hong, Jian-Yong Shao, Ying Sun, Jun Ma, Hai-Qiang Mai

Open Access Research article

Interleukin-6 trans-signaling increases the expression of carcinoembryonic antigen-related cell adhesion molecules 5 and 6 in colorectal cancer cells

Reinhild Holmer, Georg H. Wätzig, Sanjay Tiwari, Stefan Rose-John, Holger Kalthoff

Open Access Research article

Lymph nodes’ evaluation in relation to colorectal cancer staging among African Americans

Hassan Ashktorab, Temitayo Ogundipe, Hassan Brim, Anahita Shahnazi, Adeyinka O. Laiyemo, Edward Lee, Babak Shokrani, Mehdi Nouraie

Open Access Case report

Trastuzumab-induced corneal ulceration: successful no-drug treatment of a “blind” side effect in a case report

A. Orlandi, R. Fasciani, A. Cassano, A. Agresta, M. A. Calegari, A. Caporossi, C. Barone

Open Access Case report

Choroidal metastases from thymic carcinoma during pregnancy: Case Report

Sebastian P. Haen, Philipp Stroebel, Alexander Marx, Daniela Suesskind, Falko Fend, Ursula Reichmann, Hans-Georg Kopp, Lothar Kanz, Frank Mayer

Open Access Research article

Epigenetic control of phospholipase A2 receptor expression in mammary cancer cells

Mario Menschikowski, Albert Hagelgans, Brit Nacke, Carsten Jandeck, Olga Sukocheva, Gabriele Siegert

Open Access Research article

RUNX1-Evi-1 fusion gene inhibited differentiation and apoptosis in myelopoiesis: an in vivo study

Lijing Shen, Jianyi Zhu, Fangyuan Chen, Wenjie Lin, Jiayi Cai, Jihua Zhong, Hua Zhong

Open Access Research article

Resveratrol elicits anti-colorectal cancer effect by activating miR-34c-KITLG in vitro and in vivo

Shu Yang, Wenshuai Li, Haimei Sun, Bo Wu, Fengqing Ji, Tingyi Sun, Huanhuan Chang, Ping Shen, Yaxi Wang, Deshan Zhou

Open Access Research article

Comparison of the Roche cobas® 4800 and Digene Hybrid Capture® 2 HPV tests for primary cervical cancer screening in the HPV FOCAL trial

Darrel A. Cook, Wendy Mei, Laurie W. Smith, Dirk J. van Niekerk, Kathy Ceballos, Eduardo L. Franco, Andrew J. Coldman, Gina S. Ogilvie, Mel Krajden

Open Access Research article

Physical activity before and after breast cancer diagnosis and survival - the Norwegian women and cancer cohort study

Kristin Benjaminsen Borch, Tonje Braaten, Eiliv Lund, Elisabete Weiderpass

Open Access Research article

Dietary calcium intake and the risk of colorectal cancer: a case control study

Changwoo Han, Aesun Shin, Jeonghee Lee, Jeeyoo Lee, Ji Won Park, Jae Hwan Oh, Jeongseon Kim

Open Access Research article

Expression of mouse CD47 on human cancer cells profoundly increases tumor metastasis in murine models

Armando Rivera, Xinping Fu, Lihua Tao, Xiaoliu Zhang

Open Access Research article

BPIQ, a novel synthetic quinoline derivative, inhibits growth and induces mitochondrial apoptosis of lung cancer cells in vitro and in zebrafish xenograft model

Chien-Chih Chiu, Han-Lin Chou, Bing-Hung Chen, Kuo-Feng Chang, Chih-Hua Tseng, Yao Fong, Tzu-Fun Fu, Hsueh-Wei Chang, Chang-Yi Wu, Eing-Mei Tsai, Shinne-Ren Lin, Yeh-Long Chen

Open Access Research article

Evaluation of KIF23 variant 1 expression and relevance as a novel prognostic factor in patients with hepatocellular carcinoma

Xiaotong Sun, Zhongtian Jin, Xiao Song, Jingjing Wang, Yan Li, Xiaoping Qian, Yu zhang, Yanhui Yin

Open Access Research article

Lifetime use of nonsteroidal anti-inflammatory drugs and breast cancer risk: results from a prospective study of women with a sister with breast cancer

Sangmi Kim, David L. Shore, Lauren E. Wilson, Ethel I. Sanniez, Jae H. Kim, Jack A. Taylor, Dale P. Sandler

Open Access Research article

Flavones inhibit breast cancer proliferation through the Akt/FOXO3a signaling pathway

Chia-Hung Lin, Ching-Yao Chang, Kuan-Rong Lee, Hui-Ju Lin, Ter-Hsin Chen, Lei Wan

Open Access Research article

A patient perspective on shared decision making in stage I non-small cell lung cancer: a mixed methods study

Wendy Hopmans, Olga C. Damman, Suresh Senan, Koen J. Hartemink, Egbert F. Smit, Danielle R. M. Timmermans

Open Access Research article

Effect of the molecular targeted drug, erlotinib, against endometrial cancer expressing high levels of epidermal growth factor receptor

Toshio Nishimura, Kazuto Nakamura, Soichi Yamashita, Sadatomo Ikeda, Keiko Kigure, Takashi Minegishi

Open Access Research article

Epithelial ovarian cancer stem-like cells expressing α-gal epitopes increase the immunogenicity of tumor associated antigens

Xiaofen Yao, Zhangli Dong, Qiuwan Zhang, Qian Wang, Dongmei Lai

Open Access Research article

The prognostic significance of tumour-stroma ratio in endometrial carcinoma

Hannah Panayiotou, Nicolas M. Orsi, Helene H. Thygesen, Alexander I. Wright, Matthew Winder, Richard Hutson, Michele Cummings

Open Access Research article

Epigenetic regulation of CDH1 exon 8 alternative splicing in gastric cancer

Xiao-Wei Li, Bing-Yu Shi, Qing-Lan Yang, Jie Wu, Hui-Min Wu, Yu-Feng Wang, Zhi-Jiao Wu, Yi-Mei Fan, Ya-Ping Wang

Open Access Research article

Cytokeratin 20 positive circulating tumor cells are a marker for response after neoadjuvant chemoradiation but not for prognosis in patients with rectal cancer

Sebastian Hinz, Christian Röder, Jürgen Tepel, Alexander Hendricks, Clemens Schafmayer, Thomas Becker, Holger Kalthoff

Open Access Research Article

Comparative transcriptomics reveals similarities and differences between astrocytoma grades

Michael Seifert, Martin Garbe, Betty Friedrich, Michel Mittelbronn, Barbara Klink

Open Access Case report

Epirubicin: a new entry in the list of fetal cardiotoxic drugs? Intrauterine death of one fetus in a twin pregnancy. Case report and review of literature

Marialuisa Framarino-dei-Malatesta, Giuseppina Perrone, Antonella Giancotti, Flavia Ventriglia, Martina Derme, Isabella Iannini, Valentina Tibaldi, Paola Galoppi, Paolo Sammartino, Gianluca Cascialli, Roberto Brunelli

Open Access Review

The emerging role of Slit-Robo pathway in gastric and other gastro intestinal cancers

Tingting Huang, Wei Kang, Alfred S. L. Cheng, Jun Yu, Ka Fai To

Open Access Research article

Lgr5 expression is a valuable prognostic factor for colorectal cancer: evidence from a meta-analysis

Yangyan Jiang, Wenlu Li, Xin He, Hongbo Zhang, Fangzhen Jiang, Zhigang Chen

Open Access Research article

The pan-HDAC inhibitor panobinostat acts as a sensitizer for erlotinib activity in EGFR-mutated and -wildtype non-small cell lung cancer cells

Gabriele Greve, Insa Schiffmann, Dietmar Pfeifer, Milena Pantic, Julia Schüler, Michael Lübbert

Open Access Research article

In vitro and in vivo evaluation of the radiosensitizing effect of a selective FGFR inhibitor (JNJ-42756493) for rectal cancer

Maud Verstraete, Annelies Debucquoy, Annelies Gonnissen, Ruveyda Dok, Sofie Isebaert, Ellen Devos, William McBride, Karin Haustermans

Open Access Research article

Cumulative social risk exposure and risk of cancer mortality in adulthood

Rishi Caleyachetty, Parisa Tehranifar, Jeanine M. Genkinger, Justin B. Echouffo-Tcheugui, Peter Muennig

Open Access Research article

Negative effect of cyclin D1 overexpression on recurrence-free survival in stage II-IIIA lung adenocarcinoma and its expression modulation by vorinostat in vitro

Eunju Lee, DongHao Jin, Bo Bin Lee, Yujin Kim, Joungho Han, Young Mog Shim, Duk-Hwan Kim

Open Access Research article

Consistent gene expression profiles in MexTAg transgenic mouse and wild type mouse asbestos-induced mesothelioma

Cleo Robinson, Ian M. Dick, Michael J. Wise, Andrew Holloway, Dileepa Diyagama, Bruce W. S. Robinson, Jenette Creaney, Richard A. Lake

Open Access Research article

The genomic and transcriptomic landscape of anaplastic thyroid cancer: implications for therapy

Katayoon Kasaian, Sam M. Wiseman, Blair A. Walker, Jacqueline E. Schein, Yongjun Zhao, Martin Hirst, Richard A. Moore, Andrew J. Mungall, Marco A. Marra, Steven JM Jones

Open Access Research article

Serum lipidomic profiling as a useful tool for screening potential biomarkers of hepatitis B-related hepatocellular carcinoma by ultraperformance liquid chromatography–mass spectrometry

Ana Maria Passos-Castilho, Valdemir Melechco Carvalho, Karina Helena Morais Cardozo, Luciana Kikuchi, Aline Lopes Chagas, Michele Soares Gomes-Gouvêa, Fernanda Malta, Ana Catharina de Seixas-Santos Nastri, João Renato Rebello Pinho, Flair José Carrilho, Celso Francisco Hernandes Granato

Open Access Research article

High EGFR protein expression and exon 9 PIK3CA mutations are independent prognostic factors in triple negative breast cancers

William Jacot, Caroline Mollevi, Frédéric Fina, Evelyne Lopez-Crapez, Pierre-Marie Martin, Pierre-Emmanuel Colombo, Frédéric Bibeau, Gilles Romieu, Pierre-Jean Lamy

Open Access Research article

Alpha-fetoprotein normalization as a prognostic surrogate in small hepatocellular carcinoma after stereotactic body radiotherapy: a propensity score matching analysis

Jinhong Jung, Sang Min Yoon, Seungbong Han, Ju Hyun Shim, Kang Mo Kim, Young-Suk Lim, Han Chu Lee, So Yeon Kim, Jin-hong Park, Jong Hoon Kim

Open Access Study protocol

A randomized phase II study of radiation induced immune boost in operable non-small cell lung cancer (RadImmune trial)

Seyer Safi, Philipp Beckhove, Arne Warth, Axel Benner, Falk Roeder, Stefan Rieken, Juergen Debus, Hendrik Dienemann, Hans Hoffmann, Peter E. Huber

Open Access Research article

Prognostic significance of diabetes mellitus in locally advanced non-small cell lung cancer

Hisao Imai, Kyoichi Kaira, Keita Mori, Akira Ono, Hiroaki Akamatsu, Shunichi Matsumoto, Tetsuhiko Taira, Hirotsugu Kenmotsu, Hideyuki Harada, Tateaki Naito, Haruyasu Murakami, Masahiro Endo, Takashi Nakajima, Masanobu Yamada, Toshiaki Takahashi

Open Access Research article

RIZ1: a potential tumor suppressor in glioma

Chenran Zhang, Qiubei Zhu, Hua He, Lei Jiang, Qiang Qiang, Liuhua Hu, Guohan Hu, Ying Jiang, Xuehua Ding, Yicheng Lu

Open Access Research article

The preoperative SUVmax for 18F-FDG uptake predicts survival in patients with colorectal cancer

Debing Shi, Guoxiang Cai, Junjie Peng, Dawei Li, Xinxiang Li, Ye Xu, Sanjun Cai

Open Access Study protocol

Healthy Living after Cancer: a dissemination and implementation study evaluating a telephone-delivered healthy lifestyle program for cancer survivors

Elizabeth G. Eakin, Sandra C. Hayes, Marion R. Haas, Marina M. Reeves, Janette L. Vardy, Frances Boyle, Janet E. Hiller, Gita D. Mishra, Ana D. Goode, Michael Jefford, Bogda Koczwara, Christobel M. Saunders, Wendy Demark-Wahnefried, Kerry S. Courneya, Kathryn H. Schmitz, Afaf Girgis, Kate White, Kathy Chapman, Anna G. Boltong, Katherine Lane, Sandy McKiernan, Lesley Millar, Lorna O’Brien, Greg Sharplin, Polly Baldwin, Erin L. Robson

Open Access Case report

A digestive allergic reaction with hypereosinophilia imputable to docetaxel in a breast cancer patient: a case report

Diaddin Hamdan, Christophe Leboeuf, Cathy Pereira, Nathalie Jourdan, Laurence Verneuil, Guilhem Bousquet, Anne Janin

Open Access Research article

Milk consumption in relation to incidence of nasopharyngeal carcinoma in 48 countries/regions

Zhi-Ming Mai, Ching-Man Lo, Jun Xu, King-Pan Chan, Chit-Ming Wong, Maria Li Lung, Tai-Hing Lam

Open Access Research article

Up-regulation of Orai1 expression and store operated Ca2+ entry following activation of membrane androgen receptors in MCF-7 breast tumor cells

Guilai Liu, Sabina Honisch, Guoxing Liu, Sebastian Schmidt, Saad Alkahtani, Abdullah A. AlKahtane, Christos Stournaras, Florian Lang

Open Access Case report

Anti-Hu Antibody Associated Paraneoplastic Cerebellar Degeneration in Head and Neck Cancer

Florian Huemer, Thomas Melchardt, Wolfgang Tränkenschuh, Daniel Neureiter, Gerhard Moser, Teresa Magnes, Lukas Weiss, Alexander Schlattau, Clemens Hufnagl, Gerda Ricken, Romana Höftberger, Richard Greil, Alexander Egle

Open Access Study protocol

Trans-sectoral care in patients with colorectal cancer: Protocol of the randomized controlled multi-center trial Supportive Cancer Care Networkers (SCAN)

Alexander Bauer, Dirk Vordermark, Thomas Seufferlein, Hans-Joachim Schmoll, Henning Dralle, Wilfried Mau, Susanne Unverzagt, Stephanie Boese, Eva-Maria Fach, Margarete Landenberger

Open Access Case report

Long-lasting activity of trabectedin in refractory uterine leiomyosarcoma: a case report

Alberto Bongiovanni, Nada Riva, Marianna Ricci, Laura Mercatali, Chiara Liverani, Federico La Manna, Alessandro De Vita, Davide Cavaliere, Federica Pieri, Devil Oboldi, Giorgio Maria Verdecchia, Dino Amadori, Toni Ibrahim

Open Access Research article

Prevalence of hepatitis B and C and sensibility of a selective screening questionnaire in patients receiving chemotherapy for solid tumors

Mathilde Brasseur, Alexandra Heurgué-Berlot, Coralie Barbe, Cloé Brami, Jean-Baptiste Rey, Juliette Vella-Boucaud, Fadia Dabouz, Gaëtan Deslée, Florent Grange, Julien Volet, Olivier Bouché

Open Access Research article

Influences of cancer symptom knowledge, beliefs and barriers on cancer symptom presentation in relation to socioeconomic deprivation: a systematic review

Grace M. McCutchan, Fiona Wood, Adrian Edwards, Rebecca Richards, Kate E. Brain

Open Access Research article

Accuracy of volatile urine biomarkers for the detection and characterization of lung cancer

Peter J. Mazzone, Xiao-Feng Wang, Sung Lim, Humberto Choi, James Jett, Anil Vachani, Qi Zhang, Mary Beukemann, Meredith Seeley, Ray Martino, Paul Rhodes

Open Access Research article

Diagnostic performance of FDG-PET/MRI and WB-DW-MRI in the evaluation of lymphoma: a prospective comparison to standard FDG-PET/CT

Ken Herrmann, Marcelo Queiroz, Martin W. Huellner, Felipe de Galiza Barbosa, Andreas Buck, Niklaus Schaefer, Paul Stolzman, Patrick Veit-Haibach

Open Access Research article

Potential anti-cancer effect of N-hydroxy-7-(2-naphthylthio) heptanomide (HNHA), a novel histone deacetylase inhibitor, for the treatment of thyroid cancer

Seok-Mo Kim, Ki-Cheong Park, Jeong-Yong Jeon, Bup-Woo Kim, Hyeung-Kyoo Kim, Ho-Jin Chang, Seung-Hoon Choi, Cheong-Soo Park, Hang-Seok Chang

Open Access Research article

Conditional survival analysis in Korean patients with gastric cancer undergoing curative gastrectomy

Jin Won Lee, Bandar Ali, Han Mo Yoo, Cho Hyun Park, Kyo Young Song

Open Access Research article

Upregulation of NETO2 expression correlates with tumor progression and poor prognosis in colorectal carcinoma

Liang Hu, Hai-Yang Chen, Jian Cai, Guang-Zhen Yang, Dan Feng, Yan-Xia Zhai, Hui Gong, Chen-Ye Qi, Yu Zhang, Hao Fu, Qing-Ping Cai, Chun-Fang Gao

Open Access Research article

A population based perspective on children and youth with brain tumours

Vincy Chan, Jason D. Pole, Robert E. Mann, Angela Colantonio

Open Access Case report

Enormous, rapidly growing breast mass

Vivek Verma, Sanjay Muttineni, Rajesh R. Kulkarni, Edibaldo Silva-Lopez, William W. West, Robert B. Thompson

Open Access Research article

Role of HLA-G and extracellular vesicles in renal cancer stem cell-induced inhibition of dendritic cell differentiation

Cristina Grange, Marta Tapparo, Stefania Tritta, Maria Chiara Deregibus, Antonino Battaglia, Paolo Gontero, Bruno Frea, Giovanni Camussi

Open Access Research article

TGFβ isoforms and receptors mRNA expression in breast tumours: prognostic value and clinical implications

Chenfeng Chen, Kong-Nan Zhao, Paul P. Masci, Sunil R. Lakhani, Annika Antonsson, Peter T. Simpson, Luis Vitetta

Open Access Research article

Natural killer (NK) cells inhibit systemic metastasis of glioblastoma cells and have therapeutic effects against glioblastomas in the brain

Se Jeong Lee, Won Young Kang, Yeup Yoon, Ju Youn Jin, Hye Jin Song, Jung Hyun Her, Sang Mi Kang, Yu Kyeong Hwang, Kyeong Jin Kang, Kyeung Min Joo, Do-Hyun Nam

Open Access Research article

The relationship between circulating 25-hydroxyvitamin D and survival in newly diagnosed advanced non-small-cell lung cancer

Pankaj G. Vashi, Persis Edwin, Brenten Popiel, Digant Gupta

Open Access Research article

Low-power photodynamic therapy induces survival signaling in perihilar cholangiocarcinoma cells

Ruud Weijer, Mans Broekgaarden, Rowan F. van Golen, Esther Bulle, Esther Nieuwenhuis, Aldo Jongejan, Perry D. Moerland, Antoine H. C. van Kampen, Thomas M. van Gulik, Michal Heger

Open Access Research article

Clinical significance of OCT4 and SOX2 protein expression in cervical cancer

Bo Wook Kim, Hanbyoul Cho, Chel Hun Choi, Kris Ylaya, Joon-Yong Chung, Jae-Hoon Kim, Stephen M. Hewitt

Open Access Research article

Shifts in subsets of CD8+ T-cells as evidence of immunosenescence in patients with cancers affecting the lungs: an observational case-control study

Oscar Okwudiri Onyema, Lore Decoster, Rose Njemini, Louis Nuvagah Forti, Ivan Bautmans, Marc De Waele, Tony Mets

Open Access Research article

What does satisfaction with wait times mean to cancer patients?

Maria Mathews, Dana Ryan, Donna Bulman

Open Access Study protocol

Study design and protocol for moving forward: a weight loss intervention trial for African-American breast cancer survivors

Melinda R. Stolley, Lisa K. Sharp, Giamila Fantuzzi, Claudia Arroyo, Patricia Sheean, Linda Schiffer, Richard Campbell, Ben Gerber

Open Access Research article

The treatment patterns, efficacy, and safety of nab®-paclitaxel for the treatment of metastatic breast cancer in the United States: results from health insurance claims analysis

Caihua Liang, Ling Li, Cindy Duval Fraser, Amy Ko, Deyanira Corzo, Cheryl Enger, Debra Patt

Open Access Research article

A kinome siRNA screen identifies HGS as a potential target for liver cancers with oncogenic mutations in CTNNB1

Frédéric Canal, Elodie Anthony, Aurianne Lescure, Elaine Del Nery, Jacques Camonis, Franck Perez, Bruno Ragazzon, Christine Perret

Open Access Research article

Meningeal carcinomatosis underdiagnosis and overestimation: incidence in a large consecutive and unselected population of breast cancer patients

Gloria Mittica, Rebecca Senetta, Lorenzo Richiardi, Roberta Rudà, Renato Coda, Isabella Castellano, Anna Sapino, Paola Cassoni

Open Access Research article

MicroRNA Expression in Formalin-fixed Paraffin-embedded Cancer Tissue: Identifying Reference MicroRNAs and Variability

Mogens Karsbøl Boisen, Christian Dehlendorff, Dorte Linnemann, Nicolai Aagaard Schultz, Benny Vittrup Jensen, Estrid Vilma Solyom Høgdall, Julia Sidenius Johansen

Open Access Research article

MicroRNA-490-3p inhibits colorectal cancer metastasis by targeting TGFβR1

Xuehu Xu, Rong Chen, Zhifa Li, Nanqi Huang, Xiaobing Wu, Shuling Li, Yong Li, Shangbiao Wu

Open Access Research article

Ibuprofen regulates the expression and function of membrane-associated serine proteases prostasin and matriptase

Andreas C. Chai, Andrew L. Robinson, Karl X. Chai, Li-Mei Chen

Open Access Research article

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Constitutive expression of AhR and BRCA-1 promoter CpG hypermethylation as biomarkers of ERα-negative breast tumorigenesis

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Open Access Research article

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Open Access Research article

Radioactive 125I seeds inhibit cell growth and epithelial-mesenchymal transition in human glioblastoma multiforme via a ROS-mediated signaling pathway

Yunhong Tian, Qiang Xie, Jie He, Xiaojun Luo, Tao Zhou, Ying Liu, Zuoping Huang, Yunming Tian, Dan Sun, Kaitai Yao

Open Access Research article

TKTL1 expression in human malign and benign cell lines

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Adjuvante Immuntherapie verlängert Leben bei RCC

25.04.2024 Nierenkarzinom Nachrichten

Nun gibt es auch Resultate zum Gesamtüberleben: Eine adjuvante Pembrolizumab-Therapie konnte in einer Phase-3-Studie das Leben von Menschen mit Nierenzellkarzinom deutlich verlängern. Die Sterberate war im Vergleich zu Placebo um 38% geringer.

Alectinib verbessert krankheitsfreies Überleben bei ALK-positivem NSCLC

25.04.2024 NSCLC Nachrichten

Das Risiko für Rezidiv oder Tod von Patienten und Patientinnen mit reseziertem ALK-positivem NSCLC ist unter einer adjuvanten Therapie mit dem Tyrosinkinase-Inhibitor Alectinib signifikant geringer als unter platinbasierter Chemotherapie.

Bei Senioren mit Prostatakarzinom auf Anämie achten!

24.04.2024 DGIM 2024 Nachrichten

Patienten, die zur Behandlung ihres Prostatakarzinoms eine Androgendeprivationstherapie erhalten, entwickeln nicht selten eine Anämie. Wer ältere Patienten internistisch mitbetreut, sollte auf diese Nebenwirkung achten.

ICI-Therapie in der Schwangerschaft wird gut toleriert

Müssen sich Schwangere einer Krebstherapie unterziehen, rufen Immuncheckpointinhibitoren offenbar nicht mehr unerwünschte Wirkungen hervor als andere Mittel gegen Krebs.

Update Onkologie

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