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Zeitschrift

BMC Cancer

BMC Cancer 1/2015

Ausgabe 1/2015

Inhaltsverzeichnis ( 1026 Artikel )

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Liposome encapsulated zoledronate favours M1-like behaviour in murine macrophages cultured with soluble factors from breast cancer cells

Sofia Sousa, Seppo Auriola, Jukka Mönkkönen, Jorma Määttä

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Clinicopathological significance of nuclear factor (erythroid-2)-related factor 2 (Nrf2) expression in gastric cancer

Yota Kawasaki, Sumiya Ishigami, Takaaki Arigami, Yoshikazu Uenosono, Shigehiro Yanagita, Yasuto Uchikado, Yoshiaki Kita, Yuka Nishizono, Hiroshi Okumura, Akihiro Nakajo, Yuko Kijima, Kosei Maemura, Shoji Natsugoe

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Expression and clinical significance of c-Met in advanced esophageal squamous cell carcinoma

Yingying Xu, Zhi Peng, Zhongwu Li, Ming Lu, Jing Gao, Yilin Li, Yanyan Li, Lin Shen

01.12.2015 | DEBATE | Ausgabe 1/2015 Open Access

Computational cancer biology: education is a natural key to many locks

Frank Emmert-Streib, Shu-Dong Zhang, Peter Hamilton

01.12.2015 | Case report | Ausgabe 1/2015 Open Access

Molecular characteristics of endometrial cancer coexisting with peritoneal malignant mesothelioma in Li-Fraumeni-like syndrome

Angel Chao, Chyong-Huey Lai, Yun-Shien Lee, Shir-Hwa Ueng, Chiao-Yun Lin, Tzu-Hao Wang

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Androgen-regulation of the protein tyrosine phosphatase PTPRR activates ERK1/2 signalling in prostate cancer cells

Jennifer Munkley, Nicholas P Lafferty, Gabriela Kalna, Craig N Robson, Hing Y Leung, Prabhakar Rajan, David J Elliott

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Role of baseline echocardiography prior to initiation of anthracycline-based chemotherapy in breast cancer patients

Alain Mina, Hind Rafei, Maya Khalil, Yasmine Hassoun, Zeina Nasser, Arafat Tfayli

01.12.2015 | Debate | Ausgabe 1/2015 Open Access

Clinical observations on chemotherapy curable malignancies: unique genetic events, frozen development and enduring apoptotic potential

Philip Savage

01.12.2015 | Technical advance | Ausgabe 1/2015 Open Access

Microfluidic model of ductal carcinoma in situ with 3D, organotypic structure

Lauren L Bischel, David J Beebe, Kyung E Sung

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

STK33 overexpression in hypopharyngeal squamous cell carcinoma: possible role in tumorigenesis

Lingyan Huang, Chen Chen, Guodong Zhang, Yuanrong Ju, Jianzhong Zhang, Haibo Wang, Jianfeng Li

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Histopathological features predict metastatic potential in locally advanced colon carcinomas

Caren Jayasinghe, Nektaria Simiantonaki, Charles James Kirkpatrick

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Prognostic factors and treatment outcomes in patients with Small Bowel Adenocarcinoma (SBA): The Royal Marsden Hospital (RMH) experience

Khurum Khan, Clare Peckitt, Francesco Sclafani, David Watkins, Sheela Rao, Naureen Starling, Vikram Jain, Sachin Trivedi, Susannah Stanway, David Cunningham, Ian Chau

01.12.2015 | Case report | Ausgabe 1/2015 Open Access

Ewing sarcoma of the liver with multilocular cystic mass formation: a case report

Yukinori Ozaki, Yuji Miura, Shigehiro Koganemaru, Koichi Suyama, Naoko Inoshita, Takeshi Fujii, Masaji Hashimoto, Tetsuo Tamura, Kazuo Takeuchi, Toshimi Takano

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Nitric oxide donors increase PVR/CD155 DNAM-1 ligand expression in multiple myeloma cells: role of DNA damage response activation

Cinzia Fionda, Maria Pia Abruzzese, Alessandra Zingoni, Alessandra Soriani, Biancamaria Ricci, Rosa Molfetta, Rossella Paolini, Angela Santoni, Marco Cippitelli

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Downregulation of EphA5 by promoter methylation in human prostate cancer

Shibao Li, Yingfeng Zhu, Chunguang Ma, Zhenhua Qiu, Xinju Zhang, Zhihua Kang, Zhiyuan Wu, Hua Wang, Xiao Xu, Hu Zhang, Guoqiang Ren, Jianmin Tang, Xiangyu Li, Ming Guan

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

The novel histone deacetylase inhibitor, N-hydroxy-7-(2-naphthylthio) hepatonomide, exhibits potent antitumor activity due to cytochrome-c-release-mediated apoptosis in renal cell carcinoma cells

Ki Cheong Park, Jun Hyeok Heo, Jeong Yong Jeon, Hye Ji Choi, A Ra Jo, Seung Won Kim, Ho Jeong Kwon, Sung Joon Hong, Kyung Seok Han

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Methylation and expression of the tumour suppressor, PRDM5, in colorectal cancer and polyp subgroups

Catherine E Bond, Mark L Bettington, Sally-Ann Pearson, Diane M McKeone, Barbara A Leggett, Vicki LJ Whitehall

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Antihormonal agents as a strategy to improve the effect of chemo-radiation in cervical cancer: in vitro and in vivo study

Mariana Segovia-Mendoza, Rafael Jurado, Roser Mir, Luis A Medina, Heriberto Prado-Garcia, Patricia Garcia-Lopez

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

TOX3 is expressed in mammary ER+ epithelial cells and regulates ER target genes in luminal breast cancer

Akop Seksenyan, Asha Kadavallore, Ann E Walts, Brian de la Torre, Dror Berel, Samuel P Strom, Parinaz Aliahmad, Vincent A Funari, Jonathan Kaye

01.12.2015 | Case report | Ausgabe 1/2015 Open Access

Bilateral Diffuse Uveal Melanocytic Proliferation (BDUMP) associated with B-cell lymphoma: report of a rare case

Maria Pefkianaki, Rupesh Agrawal, Parul Desai, Carlos Pavesio, Mandeep S Sagoo

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Cell fusion between gastric epithelial cells and mesenchymal stem cells results in epithelial-to-mesenchymal transition and malignant transformation

Xianghui He, Baosong Li, Yang Shao, Na Zhao, Yiling Hsu, Zhixiang Zhang, Liwei Zhu

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Caveolin-1 accumulation in the tongue cancer tumor microenvironment is significantly associated with poor prognosis: an in-vivo and in-vitro study

Marilena Vered, Meri Lehtonen, Lari Hotakainen, Emma Pirilä, Susanna Teppo, Pia Nyberg, Raija Sormunen, Ayelet Zlotogorski-Hurvitz, Tuula Salo, Dan Dayan

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Development of a semi-conductor sequencing-based panel for genotyping of colon and lung cancer by the Onconetwork consortium

Bastiaan BJ Tops, Nicola Normanno, Henriette Kurth, Eliana Amato, Andrea Mafficini, Nora Rieber, Delphine Le Corre, Anna Maria Rachiglio, Anne Reiman, Orla Sheils, Christoph Noppen, Ludovic Lacroix, Ian A Cree, Aldo Scarpa, Marjolijn JL Ligtenberg, Pierre Laurent-Puig

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Prognostic survival model for people diagnosed with invasive cutaneous melanoma

Peter D Baade, Patrick Royston, Philipa H Youl, Martin A Weinstock, Alan Geller, Joanne F Aitken

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Weight and weight change following breast cancer: evidence from a prospective, population-based, breast cancer cohort study

Dimitrios Vagenas, Tracey DiSipio, Diana Battistutta, Wendy Demark-Wahnefried, Sheree Rye, John Bashford, Chris Pyke, Christobel Saunders, Sandra C Hayes

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

MiR-130b plays an oncogenic role by repressing PTEN expression in esophageal squamous cell carcinoma cells

Tingting Yu, Risheng Cao, Shuo Li, Mingen Fu, Lihua Ren, Weixu Chen, Hong Zhu, Qiang Zhan, Ruihua Shi

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Association of PALB2 sequence variants with the risk of familial and early-onset breast cancer in a South-American population

Yessica Leyton, Patricio Gonzalez-Hormazabal, Rafael Blanco, Teresa Bravo, Ricardo Fernandez-Ramires, Sebastian Morales, Natalia Landeros, Jose M Reyes, Octavio Peralta, Julio C Tapia, Fernando Gomez, Enrique Waugh, Gladys Ibañez, Janara Pakomio, Gilberto Grau, Lilian Jara

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

MET FISH-positive status predicts short progression-free survival and overall survival after gefitinib treatment in lung adenocarcinoma with EGFR mutation

Rintaro Noro, Masahiro Seike, Fenfei Zou, Chie Soeno, Kuniko Matsuda, Teppei Sugano, Nobuhiko Nishijima, Masaru Matsumoto, Kazuhiro Kitamura, Seiji Kosaihira, Yuji Minegishi, Akinobu Yoshimura, Kaoru Kubota, Akihiko Gemma

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Retrospective review using targeted deep sequencing reveals mutational differences between gastroesophageal junction and gastric carcinomas

Hector H Li-Chang, Katayoon Kasaian, Ying Ng, Amy Lum, Esther Kong, Howard Lim, Steven JM Jones, David G Huntsman, David F Schaeffer, Stephen Yip

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Serum HE4 detects recurrent endometrial cancer in patients undergoing routine clinical surveillance

Donal J Brennan, Andreas Hackethal, Kristy P Mann, Irene Mutz-Dehbalaie, Heidi Fiegl, Christian Marth, Andreas Obermair

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Melatonin attenuates the TLR4-mediated inflammatory response through MyD88- and TRIF-dependent signaling pathways in an in vivo model of ovarian cancer

Luiz Gustavo A Chuffa, Beatriz A Fioruci-Fontanelli, Leonardo O Mendes, Fábio R Ferreira Seiva, Marcelo Martinez, Wagner J Fávaro, Raquel F Domeniconi, Patrícia FF Pinheiro, Lucilene Delazari dos Santos, Francisco Eduardo Martinez

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

High-density SNP arrays improve detection of HER2 amplification and polyploidy in breast tumors

Thomas v O Hansen, Jonas Vikesaa, Sine S Buhl, Henrik H Rossing, Vera Timmermans-Wielenga, Finn C Nielsen

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Concurrent paclitaxel-based chemo-radiotherapy for post-surgical microscopic residual tumor at the bronchial margin (R1 resection) in non-small-cell lung cancer

Meixiang Zhou, Tao Li, Yongmei Liu, Changjin Sun, Na Li, Yong Xu, Jiang Zhu, Zhenyu Ding, Yongsheng Wang, Meijuan Huang, Feng Peng, Jin Wang, Li Ren, You Lu, Youling Gong

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

High levels of dietary soy decrease mammary tumor latency and increase incidence in MTB-IGFIR transgenic mice

Katrina L Watson, Leanne Stalker, Robert A Jones, Roger A Moorehead

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Cholangiocarcinoma: spectrum of appearances on Gd-EOB-DTPA-enhanced MR imaging and the effect of biliary function on signal intensity

Shi-Ting Feng, Ling Wu, Huasong Cai, Tao Chan, Yanji Luo, Zhi Dong, Keguo Zheng, Zi-Ping Li

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Trogocytosis-mediated expression of HER2 on immune cells may be associated with a pathological complete response to trastuzumab-based primary systemic therapy in HER2-overexpressing breast cancer patients

Eiji Suzuki, Tatsuki R Kataoka, Masahiro Hirata, Kosuke Kawaguchi, Mariko Nishie, Hironori Haga, Masakazu Toi

01.12.2015 | Study protocol | Ausgabe 1/2015 Open Access

Supervised physical exercise to improve the quality of life of cancer patients: the EFICANCER randomised controlled trial

Aintzane Sancho, Sergio Carrera, Marisol Arietaleanizbeascoa, Veronica Arce, Nere Mendizabal Gallastegui, Anna Giné March, Aitor Sanz-Guinea, Araceli Eskisabel, Ana Lopez Rodriguez, Rosa A Martín, Guillermo Lopez-Vivanco, Gonzalo Grandes

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Rosiglitazone may reduce non-melanoma skin cancer risk in Taiwanese

Chin-Hsiao Tseng

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Fluoroquinolone resistance in bacteremic and low risk febrile neutropenic patients with cancer

Sheng Zhang, Qing Wang, Yun Ling, Xichun Hu

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Number of negative lymph nodes is associated with disease-free survival in patients with breast cancer

San-Gang Wu, Jia-Yuan Sun, Juan Zhou, Feng-Yan Li, Qin Lin, Huan-Xin Lin, Xun-Xing Guan, Zhen-Yu He

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

S100A4-neutralizing antibody suppresses spontaneous tumor progression, pre-metastatic niche formation and alters T-cell polarization balance

Birgitte Grum-Schwensen, Jörg Klingelhöfer, Mette Beck, Charlotte Menné Bonefeld, Petra Hamerlik, Per Guldberg, Mariam Grigorian, Eugene Lukanidin, Noona Ambartsumian

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Clonal distribution of BCR-ABL1 mutations and splice isoforms by single-molecule long-read RNA sequencing

Lucia Cavelier, Adam Ameur, Susana Häggqvist, Ida Höijer, Nicola Cahill, Ulla Olsson-Strömberg, Monica Hermanson

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Clinical outcome of patients with pancreatic metastases from renal cell cancer

Takeshi Yuasa, Naoko Inoshita, Akio Saiura, Shinya Yamamoto, Shinji Urakami, Hitoshi Masuda, Yasuhisa Fujii, Iwao Fukui, Yuichi Ishikawa, Junji Yonese

01.12.2015 | Study protocol | Ausgabe 1/2015 Open Access

GRECCAR 8: impact on survival of the primary tumor resection in rectal cancer with unresectable synchronous metastasis: a randomized multicentre study

Eddy Cotte, Laurent Villeneuve, Guillaume Passot, Gilles Boschetti, Sylvie Bin-Dorel, Yves Francois, Olivier Glehen, The French Research Group of Rectal Cancer Surgery (GRECCAR)

01.12.2015 | Study protocol | Ausgabe 1/2015 Open Access

NEOSCOPE: a randomised Phase II study of induction chemotherapy followed by either oxaliplatin/capecitabine or paclitaxel/carboplatin based chemoradiation as pre-operative regimen for resectable oesophageal adenocarcinoma

Somnath Mukherjee, Christopher N Hurt, Sarah Gwynne, Andrew Bateman, Simon Gollins, Ganesh Radhakrishna, Maria Hawkins, Jo Canham, Wyn Lewis, Heike I Grabsch, Ricky A Sharma, Wendy Wade, Rhydian Maggs, Bethan Tranter, Ashley Roberts, David Sebag-Montefiore, Timothy Maughan, Gareth Griffiths, Tom Crosby

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Occupational exposure and sinonasal cancer: a systematic review and meta-analysis

Alessandra Binazzi, Pierpaolo Ferrante, Alessandro Marinaccio

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

YY1 suppresses FEN1 over-expression and drug resistance in breast cancer

Jianwei Wang, Lina Zhou, Zhi Li, Ting Zhang, Wenpeng Liu, Zheng Liu, Yate-Ching Yuan, Fan Su, Lu Xu, Yan Wang, Xiaotong Zhou, Hong Xu, Yuejin Hua, Ying-Jie Wang, Li Zheng, Yue-E Teng, Binghui Shen

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Impact of diabetes type II and chronic inflammation on pancreatic cancer

Dietmar Zechner, Tobias Radecke, Jonas Amme, Florian Bürtin, Ann-Christin Albert, Lars Ivo Partecke, Brigitte Vollmar

01.12.2015 | Study protocol | Ausgabe 1/2015 Open Access

Single arm NCRI phase II study of CHOP in combination with Ofatumumab in induction and maintenance for patients with newly diagnosed Richter’s syndrome

Toby A Eyre, Ruth Clifford, Corran Roberts, Lucy Boyle, Anne Francis, Anna Schuh, Susan J Dutton

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Co-expression of S100A14 and S100A16 correlates with a poor prognosis in human breast cancer and promotes cancer cell invasion

Mizuko Tanaka, Naoki Ichikawa-Tomikawa, Namiko Shishito, Keisuke Nishiura, Tomiko Miura, Ayumi Hozumi, Hideki Chiba, Sayaka Yoshida, Tohru Ohtake, Takashi Sugino

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Gamma knife radiosurgery for elderly patients with brain metastases: evaluation of scoring systems that predict survival

Jae-Young Park, Kyung-Sub Moon, Kyung-Hwa Lee, Sa-Hoe Lim, Woo-Youl Jang, Hyeseon Lee, Tae-Young Jung, In-Young Kim, Shin Jung

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

The differential anti-tumour effects of zoledronic acid in breast cancer – evidence for a role of the activin signaling pathway

Caroline Wilson, Penelope Ottewell, Robert E Coleman, Ingunn Holen

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Plasma clusterin as a candidate pre-diagnosis marker of colorectal cancer risk in the Florence cohort of the European Prospective Investigation into Cancer and Nutrition: a pilot study

Michela Bertuzzi, Cristina Marelli, Renzo Bagnati, Alessandro Colombi, Roberto Fanelli, Calogero Saieva, Marco Ceroti, Benedetta Bendinelli, Saverio Caini, Luisa Airoldi, Domenico Palli

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Impact of age and gender on tumor related prognosis in gastrointestinal stromal tumors (GIST)

Klaus Kramer, Uwe Knippschild, Benjamin Mayer, Kira Bögelspacher, Hanno Spatz, Doris Henne-Bruns, Abbas Agaimy, Matthias Schwab, Michael Schmieder

01.12.2015 | Case report | Ausgabe 1/2015 Open Access

Melan-A/MART-1 immunity in a EWS-ATF1 translocated clear cell sarcoma patient treated with sunitinib: a case report

Marcella Tazzari, Elena Palassini, Barbara Vergani, Antonello Villa, Francesca Rini, Tiziana Negri, Chiara Colombo, Flavio Crippa, Carlo Morosi, Paolo G Casali, Silvana Pilotti, Silvia Stacchiotti, Licia Rivoltini, Chiara Castelli

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Phase II study of preoperative bevacizumab, capecitabine and radiotherapy for resectable locally-advanced rectal cancer

Margarita García, Mercedes Martinez-Villacampa, Cristina Santos, Valentin Navarro, Alex Teule, Ferran Losa, Aleydis Pisa, Maria Cambray, Gemma Soler, Laura Lema, Esther Kreisler, Agnes Figueras, Xavier San Juan, Francesc Viñals, Sebastiano Biondo, Ramon Salazar

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

A randomized phase II study of capecitabine-based chemoradiation with or without bevacizumab in resectable locally advanced rectal cancer: clinical and biological features

Ramon Salazar, Jaume Capdevila, Berta Laquente, Jose Luis Manzano, Carles Pericay, Mercedes Martínez Villacampa, Carlos López, Ferran Losa, Maria Jose Safont, Auxiliadora Gómez, Vicente Alonso, Pilar Escudero, Javier Gallego, Javier Sastre, Cristina Grávalos, Sebastiano Biondo, Amalia Palacios, Enrique Aranda

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Next generation sequencing of exceptional responders with BRAF-mutant melanoma: implications for sensitivity and resistance

Jennifer Wheler, Roman Yelensky, Gerald Falchook, Kevin B Kim, Patrick Hwu, Apostolia M Tsimberidou, Philip J Stephens, David Hong, Maureen T Cronin, Razelle Kurzrock

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Adjuvant chemotherapy for stage III colon cancer: relative dose intensity and survival among veterans

Sherrie L Aspinall, Chester B Good, Xinhua Zhao, Francesca E Cunningham, Bernadette B Heron, Mark Geraci, Vida Passero, Roslyn A Stone, Kenneth J Smith, Renee Rogers, Jenna Shields, Megan Sartore, D Patrick Boyle, Sherry Giberti, John Szymanski, Doug Smith, Allen Ha, Jolynn Sessions, Shawn Depcinski, Shane Fishco, Irvin Molina, Tanja Lepir, Carmela Jean, Lymaris Cruz-Diaz, Jessica Motta, Rebeca Calderon-Vargas, Janelle Maland, Sean Keefe, Marshall Tague, Alice Leone, Brian Glovack, Blair Kaplan, Sean Cosgriff, Lindsay Kaster, Ivy Tonnu-Mihara, Kimmai Nguyen, Jenna Carmichael, Linda Clifford, Kan Lu, Gurkamal Chatta

01.12.2015 | Study protocol | Ausgabe 1/2015 Open Access

Return to work in sick-listed cancer survivors with job loss: design of a randomised controlled trial

Martine P van Egmond, Saskia FA Duijts, Sylvia J Vermeulen, Allard J van der Beek, Johannes R Anema

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Identification of a novel microRNA signature associated with intrahepatic cholangiocarcinoma (ICC) patient prognosis

Mei-Yin Zhang, Shu-Hong Li, Guo-Liang Huang, Guo-He Lin, Ze-Yu Shuang, Xiang-Ming Lao, Li Xu, Xiao-Jun Lin, Hui-Yun Wang, Sheng-Ping Li

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Significant correlation between urinary N1, N12-diacetylspermine and tumor invasiveness in patients with clinical stage IA non-small cell lung cancer

Yusuke Takahashi, Hirotoshi Horio, Koji Sakaguchi, Kyoko Hiramatsu, Masao Kawakita

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Breast and prostate cancer patients differ significantly in their serum Thymidine kinase 1 (TK1) specific activities compared with those hematological malignancies and blood donors: implications of using serum TK1 as a biomarker

Kiran Kumar Jagarlamudi, Lars Olof Hansson, Staffan Eriksson

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Increased expression of colony stimulating factor-1 is a predictor of poor prognosis in patients with clear-cell renal cell carcinoma

Liu Yang, Qian Wu, Le Xu, Weijuan Zhang, Yu Zhu, Haiou Liu, Jiejie Xu, Jianxin Gu

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Multiple myeloma cells alter the senescence phenotype of bone marrow mesenchymal stromal cells under participation of the DLK1-DIO3 genomic region

Rimma Berenstein, Olga Blau, Axel Nogai, Marlies Waechter, Ekaterina Slonova, Martin Schmidt-Hieber, Annegret Kunitz, Antonio Pezzutto, Bernd Doerken, Igor Wolfgang Blau

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Circadian variation in plasma 5-fluorouracil concentrations during a 24 hour constant-rate infusion

Gini F Fleming, Philip Schumm, Greg Friberg, Mark J Ratain, Uchenna O Njiaju, Richard L Schilsky

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Dermcidin exerts its oncogenic effects in breast cancer via modulation of ERBB signaling

Jasna Bancovik, Dayson F Moreira, Daniel Carrasco, Jun Yao, Dale Porter, Ricardo Moura, Anamaria Camargo, Cibely C Fontes-Oliveira, Miguel G Malpartida, Silvia Carambula, Edouard Vannier, Bryan E Strauss, Alda Wakamatsu, Venancio AF Alves, Angela F Logullo, Fernando A Soares, Kornelia Polyak, José E Belizário

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Targeting cMET with INC280 impairs tumour growth and improves efficacy of gemcitabine in a pancreatic cancer model

Franziska Brandes, Katharina Schmidt, Christine Wagner, Julia Redekopf, Hans Jürgen Schlitt, Edward Kenneth Geissler, Sven Arke Lang

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Sex differences in cancer survival in Estonia: a population-based study

Kaire Innos, Peeter Padrik, Vahur Valvere, Tiiu Aareleid

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Incidence, time course and independent risk factors for metachronous peritoneal carcinomatosis of gastric origin – a longitudinal experience from a prospectively collected database of 1108 patients

Florian Seyfried, Burkhard H von Rahden, Alexander D Miras, Martin Gasser, Uwe Maeder, Volker Kunzmann, Christoph-Thomas Germer, Jörg OW Pelz, Alexander G Kerscher

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Lung neuroendocrine tumors: correlation of ubiquitinylation and sumoylation with nucleo-cytosolic partitioning of PTEN

Stéphane Collaud, Verena Tischler, Andrej Atanassoff, Thomas Wiedl, Paul Komminoth, Christian Oehlschlegel, Walter Weder, Alex Soltermann

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Metaplastic breast cancer: a comparison between the most common histologies with poor immunohistochemistry factors

Salim Abraham Barquet-Muñoz, Silvia Patricia Villarreal-Colin, Luis Alonso Herrera-Montalvo, Ernesto Soto-Reyes, Carlos Pérez-Plasencia, Jaime Coronel-Martínez, Delia Pérez-Montiel, Rafael Vázquez-Romo, David Cantú de León

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Enhanced tumour cell nuclear targeting in a tumour progression model

Michael S Nastasie, Helmut Thissen, David A Jans, Kylie M Wagstaff

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Effects of supervised exercise on cancer-related fatigue in breast cancer survivors: a systematic review and meta-analysis

José Francisco Meneses-Echávez, Emilio González-Jiménez, Robinson Ramírez-Vélez

01.12.2015 | Study protocol | Ausgabe 1/2015 Open Access

A phase II study of weekly irinotecan in patients with locally advanced or metastatic HER2- negative breast cancer and increased copy numbers of the topoisomerase 1 (TOP1) gene: a study protocol

Iben Kümler, Eva Balslev, Jan Stenvang, Nils Brünner, Dorte Nielsen

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Local control in metastatic neuroblastoma in children over 1 year of age

Maria Antonietta De Ioris, Alessandro Crocoli, Benedetta Contoli, Maria Carmen Garganese, Gianluigi Natali, Paolo Tomà, Alessandro Jenkner, Renata Boldrini, Maria Debora De Pasquale, Giuseppe Maria Milano, Silvia Madafferi, Aurora Castellano, Franco Locatelli, Alessandro Inserra

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Gastric cancer-associated enhancement of von Willebrand factor is regulated by vascular endothelial growth factor and related to disease severity

Xia Yang, Hai-jian Sun, Zhi-rong Li, Hao Zhang, Wei-jun Yang, Bing Ni, Yu-zhang Wu

01.12.2015 | Technical advance | Ausgabe 1/2015 Open Access

Screening of exon 11 of BRCA1 gene using the high resolution melting approach for diagnosis in Moroccan breast cancer patients

Meryam El Khachibi, Brehima Diakite, Khalil Hamzi, Abdallah Badou, Mohamed Amine Senhaji, Amina Bakhchane, Hassan Jouhadi, Abdelhamid Barakat, Abdellatif Benider, Sellama Nadifi

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

The role of HGF/MET and FGF/FGFR in fibroblast-derived growth stimulation and lapatinib-resistance of esophageal squamous cell carcinoma

Shin Saito, Kazue Morishima, Takashi Ui, Hiroko Hoshino, Daisuke Matsubara, Shumpei Ishikawa, Hiroyuki Aburatani, Masashi Fukayama, Yoshinori Hosoya, Naohiro Sata, Alan K Lefor, Yoshikazu Yasuda, Toshiro Niki

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

The prognostic significance of age in operated and non-operated colorectal cancer

Jing Li, Zhu Wang, Xin Yuan, Lichun Xu, Jiandong Tong

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Human non-small cell lung cancer expresses putative cancer stem cell markers and exhibits the transcriptomic profile of multipotent cells

Norashikin Zakaria, Narazah Mohd Yusoff, Zubaidah Zakaria, Moon Nian Lim, Puteri J Noor Baharuddin, Kamal Shaik Fakiruddin, Badrul Yahaya

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Tumor evolution and intratumor heterogeneity of an epithelial ovarian cancer investigated using next-generation sequencing

Jung-Yun Lee, Jung-Ki Yoon, Boyun Kim, Soochi Kim, Min A Kim, Hyeonseob Lim, Duhee Bang, Yong-Sang Song

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

HNRNP G and HTRA2-BETA1 regulate estrogen receptor alpha expression with potential impact on endometrial cancer

Marc Hirschfeld, Yi Qin Ouyang, Markus Jaeger, Thalia Erbes, Marzenna Orlowska-Volk, Axel zur Hausen, Elmar Stickeler

01.12.2015 | Case report | Ausgabe 1/2015 Open Access

Ipilimumab and immune-mediated adverse events: a case report of anti-CTLA4 induced ileitis

Olga Venditti, Delia De Lisi, Marco Caricato, Damiano Caputo, Gabriella Teresa Capolupo, Chiara Taffon, Elisa Pagliara, Sofia Battisi, Anna Maria Frezza, Andrea Onetti Muda, Giuseppe Tonini, Daniele Santini

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Epidermal growth factor receptor gene mutation status in pure squamous-cell lung cancer in Chinese patients

Qing Zhang, Lei Zhu, Jie Zhang

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Radiosensitization with combined use of olaparib and PI-103 in triple-negative breast cancer

Na Young Jang, Dan Hyo Kim, Bong Jun Cho, Eun Jung Choi, Jong-Soo Lee, Hong-Gyun Wu, Eui Kyu Chie, In Ah Kim

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Role of SMC1A overexpression as a predictor of poor prognosis in late stage colorectal cancer

Jianwei Wang, Shaojun Yu, Liming Cui, Wenhui Wang, Jun Li, Ke Wang, Xinyuan Lao

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Fibulin-4 is associated with tumor progression and a poor prognosis in ovarian carcinomas

Jie Chen, Zhao Liu, Shuang Fang, Rui Fang, Xi Liu, Yueran Zhao, XiangXin Li, Lei Huang, Jie Zhang

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

MiRNA-141 and miRNA-200b are closely related to invasive ability and considered as decision-making biomarkers for the extent of PLND during cystectomy

Wentao Liu, Lin Qi, Hui Lv, Xiongbing Zu, Minfeng Chen, Jun Wang, Longfei Liu, Feng Zeng, Yuan Li

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

ADAM12-L is a direct target of the miR-29 and miR-200 families in breast cancer

Sara Duhachek-Muggy, Anna Zolkiewska

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

International trends in primary liver cancer incidence from 1973 to 2007

Yue Zhang, Jian-Song Ren, Ju-Fang Shi, Ni Li, Yu-Ting Wang, Chunfeng Qu, Yawei Zhang, Min Dai

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Is stereotactic radiosurgery a rational treatment option for brain metastases from small cell lung cancer? A retrospective analysis of 70 consecutive patients

Shoji Yomo, Motohiro Hayashi

01.12.2015 | Reviewer acknowledgement | Ausgabe 1/2015 Open Access

BMC Cancer reviewer acknowledgement 2014

Dafne Solera

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Resveratrol suppresses epithelial-to-mesenchymal transition in colorectal cancer through TGF-β1/Smads signaling pathway mediated Snail/E-cadherin expression

Qing Ji, Xuan Liu, Zhifen Han, Lihong Zhou, Hua Sui, Linlin Yan, Haili Jiang, Jianlin Ren, Jianfeng Cai, Qi Li

01.12.2015 | Study protocol | Ausgabe 1/2015 Open Access

The effect of individualized NUTritional counseling on muscle mass and treatment outcome in patients with metastatic COLOrectal cancer undergoing chemotherapy: a randomized controlled trial protocol

Anne van der Werf, Susanne Blauwhoff-Buskermolen, Jacqueline AE Langius, Johannes Berkhof, Henk MW Verheul, Marian AE de van der Schueren

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

The association between human papillomavirus 16 and esophageal cancer in Chinese population: a meta-analysis

Shao-Kai Zhang, Lan-Wei Guo, Qiong Chen, Meng Zhang, Shu-Zheng Liu, Pei-Liang Quan, Jian-Bang Lu, Xi-Bin Sun

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

The DNA load of six high-risk human papillomavirus types and its association with cervical lesions

Luisa Del Río-Ospina, Sara Cecilia Soto-De León, Milena Camargo, Darwin Andrés Moreno-Pérez, Ricardo Sánchez, Antonio Pérez-Prados, Manuel Elkin Patarroyo, Manuel Alfonso Patarroyo

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Tertiary lymphoid structures are associated with higher tumor grade in primary operable breast cancer patients

Stine L Figenschau, Silje Fismen, Kristin A Fenton, Christopher Fenton, Elin S Mortensen

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Nuclear expression of p65 (RelA) in patients receiving post-operative radiotherapy for locally advanced squamous cell carcinoma of the head and neck

Dirk Rades, Stefan Huttenlocher, Nina D Seibold, Maximilian P Gebhard, Christoph Thorns, Katrin Hasselbacher, Barbara Wollenberg, Steven E Schild

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Lymphangiogenesis in Gastric Cancer regulated through Akt/mTOR-VEGF-C/VEGF-D axis

Hongxia Chen, Runnian Guan, Yupeng Lei, Jianyong Chen, Qi Ge, Xiaoshen Zhang, Ruoxu Dou, Hongyuan Chen, Hao Liu, Xiaolong Qi, Xiaodong Zhou, Changyan Chen

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Cell type- and tumor zone-specific expression of pVEGFR-1 and its ligands influence colon cancer metastasis

Caren Jayasinghe, Nektaria Simiantonaki, Charles James Kirkpatrick

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Retrospective analysis of the impact of platinum dose reduction and chemotherapy delays on the outcomes of stage III ovarian cancer patients

Sigita Liutkauskiene, Rasa Janciauskiene, Kristina Jureniene, Saulius Grizas, Rasa Malonyte, Elona Juozaityte

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Vitamin D and cancer mortality in elderly women

Germaine Wong, Wai Hon Lim, Joshua Lewis, Jonathan C Craig, Robin Turner, Kathy Zhu, Ee Mun Lim, Richard Prince

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Astrocyte elevated gene-1(AEG-1) induces epithelial-mesenchymal transition in lung cancer through activating Wnt/β-catenin signaling

Weiling He, Shanyang He, Zuo Wang, Hongwei Shen, Wenfeng Fang, Yang Zhang, Wei Qian, Millicent Lin, Jinglun Yuan, Jinyang Wang, Wenhua Huang, Liantang Wang, Zunfu Ke

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

The prognostic role of preoperative serum albumin levels in glioblastoma patients

Sheng Han, Yanming Huang, Zhonghua Li, Haipei Hou, Anhua Wu

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Inhibition of SHP2 in basal-like and triple-negative breast cells induces basal-to-luminal transition, hormone dependency, and sensitivity to anti-hormone treatment

Hua Zhao, Yehenew M Agazie

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Hunk/Mak-v is a negative regulator of intestinal cell proliferation

Karen R Reed, Igor V Korobko, Natalia Ninkina, Elena V Korobko, Ben R Hopkins, James L Platt, Vladimir Buchman, Alan R Clarke

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Impact of comorbidities and use of common medications on cancer and non-cancer specific survival in esophageal carcinoma

Li-Ru He, Wei Qiao, Zhong-Xing Liao, Ritsuko Komaki, Linus Ho, Wayne L Hofstetter, Steven H Lin

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

The effect of chemotherapeutic agents on tumor vasculature in subcutaneous and orthotopic human tumor xenografts

Andrea S Fung, Carol Lee, Man Yu, Ian F Tannock

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Nuclear factor I-C regulates E-cadherin via control of KLF4 in breast cancer

Hye-Kyung Lee, Dong-Seol Lee, Joo-Cheol Park

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Clinically significant association between the maximum standardized uptake value on 18F-FDG PET and expression of phosphorylated Akt and S6 kinase for prediction of the biological characteristics of renal cell cancer

Tomoya Mizuno, Takao Kamai, Hideyuki Abe, Setsu Sakamoto, Kazuhiro Kitajima, Daisaku Nishihara, Hideo Yuki, Tsunehito Kambara, Hironori Betsunoh, Masahiro Yashi, Yoshitatsu Fukabori, Yasushi Kaji, Ken-Ichiro Yoshida

01.12.2015 | Case report | Ausgabe 1/2015 Open Access

Oromandibular dystonia: a serious side effect of capecitabine

Melanie JM van Pelt-Sprangers, Eric CT Geijteman, Jelmer Alsma, Ingrid A Boere, Ron HJ Mathijssen, Stephanie CE Schuit

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

The prognostic value of combined TGF-β1 and ELF in hepatocellular carcinoma

Fei Ji, Shun-Jun Fu, Shun-Li Shen, Long-Juan Zhang, Qing-Hua Cao, Shao-Qiang Li, Bao-Gang Peng, Li-Jian Liang, Yun-Peng Hua

01.12.2015 | Research Article | Ausgabe 1/2015 Open Access

Prediction of resistance to chemotherapy in ovarian cancer: a systematic review

Katherine L Lloyd, Ian A Cree, Richard S Savage

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Overexpression of Nrf2 attenuates Carmustine-induced cytotoxicity in U87MG human glioma cells

Sangeetha Sukumari-Ramesh, Niyathi Prasad, Cargill H Alleyne Jr, John R Vender, Krishnan M Dhandapani

01.12.2015 | Case report | Ausgabe 1/2015 Open Access

Successful control of heavily pretreated metastatic gastric cancer with the mTOR inhibitor everolimus (RAD001) in a patient with PIK3CA mutation and pS6 overexpression

Ji Hyun Park, Min-Hee Ryu, Young Soo Park, Sook Ryun Park, Young-Soon Na, Baek-Yeol Rhoo, Yoon-Koo Kang

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Can daily intake of aspirin and/or statins influence the behavior of non-muscle invasive bladder cancer? A retrospective study on a cohort of patients undergoing transurethral bladder resection

Antonio Luigi Pastore, Giovanni Palleschi, Andrea Fuschi, Luigi Silvestri, Yazan Al Salhi, Elisabetta Costantini, Alessandro Zucchi, Vincenzo Petrozza, Cosimo de Nunzio, Antonio Carbone

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Association of angiogenic factors with prognosis in esophageal cancer

Lena Dreikhausen, Susanne Blank, Leila Sisic, Ulrike Heger, Wilko Weichert, Dirk Jäger, Thomas Bruckner, Natalia Giese, Lars Grenacher, Christine Falk, Katja Ott, Thomas Schmidt

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Results of multicenter double-blind placebo-controlled phase II clinical trial of Panagen preparation to evaluate its leukostimulatory activity and formation of the adaptive immune response in patients with stage II-IV breast cancer

Anastasia S Proskurina, Tatiana S Gvozdeva, Ekaterina A Alyamkina, Evgenia V Dolgova, Konstantin E Orishchenko, Valeriy P Nikolin, Nelly A Popova, Sergey V Sidorov, Elena R Chernykh, Alexandr A Ostanin, Olga Y Leplina, Victoria V Dvornichenko, Dmitriy M Ponomarenko, Galina S Soldatova, Nikolay A Varaksin, Tatiana G Ryabicheva, Stanislav N Zagrebelniy, Vladimir A Rogachev, Sergey S Bogachev, Mikhail A Shurdov

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Lack of significant association between serum inflammatory cytokine profiles and the presence of colorectal adenoma

Curtis J Henry, Rebecca L Sedjo, Andrii Rozhok, Jennifer Salstrom, Dennis Ahnen, Theodore R Levin, Ralph D’Agostino Jr, Steven Haffner, James DeGregori, Tim Byers

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

The association of alcohol consumption with mammographic density in a multiethnic urban population

Zoe Quandt, Julie D Flom, Parisa Tehranifar, Diane Reynolds, Mary Beth Terry, Jasmine A McDonald

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Microsatellite instability and mutations in BRAF and KRAS are significant predictors of disseminated disease in colon cancer

Helgi Birgisson, Karolina Edlund, Ulrik Wallin, Lars Påhlman, Hanna Göransson Kultima, Markus Mayrhofer, Patrick Micke, Anders Isaksson, Johan Botling, Bengt Glimelius, Magnus Sundström

01.12.2015 | Research Article | Ausgabe 1/2015 Open Access

Patterns of chromosomal copy-number alterations in intrahepatic cholangiocarcinoma

Cyril Dalmasso, Wassila Carpentier, Catherine Guettier, Sophie Camilleri-Broët, Wyllians Vendramini Borelli, Cedália Rosane Campos dos Santos, Denis Castaing, Jean-Charles Duclos-Vallée, Philippe Broët

01.12.2015 | Study protocol | Ausgabe 1/2015 Open Access

Study protocol of REGOSARC trial: activity and safety of regorafenib in advanced soft tissue sarcoma: a multinational, randomized, placebo-controlled, phase II trial

Thomas Brodowicz, Bernadette Liegl-Atzwager, Emmanuelle Tresch, Sophie Taieb, Andrew Kramar, Viktor Gruenwald, Marie Vanseymortier, Stéphanie Clisant, Jean-Yves Blay, Axel Le Cesne, Nicolas Penel

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

The significance of the co-existence of osteopontin and tumor-associated macrophages in gastric cancer progression

Chang-Ni Lin, Chih-Jung Wang, Ying-Jui Chao, Ming-Derg Lai, Yan-Shen Shan

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Surface antigen expression on peripheral blood monocytes in women with gynecologic malignancies

Maciej Jóźwik, Osazee E Okungbowa, Alina Lipska, Marcin Jóźwik, Marzena Smoktunowicz, Andrzej Semczuk, Michał Jóźwik, Piotr Radziwon

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

A functional in vitro model of heterotypic interactions reveals a role for interferon-positive carcinoma associated fibroblasts in breast cancer

Abdel Nasser Hosein, Julie Livingstone, Marguerite Buchanan, James F Reid, Michael Hallett, Mark Basik

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

eIF6 over-expression increases the motility and invasiveness of cancer cells by modulating the expression of a critical subset of membrane-bound proteins

Michela Pinzaglia, Claudia Montaldo, Dorina Polinari, Mattei Simone, Anna La Teana, Marco Tripodi, Carmine Mancone, Paola Londei, Dario Benelli

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

COP1, the negative regulator of ETV1, influences prognosis in triple-negative breast cancer

Mao Ouyang, Hua Wang, Jieyi Ma, Weiming Lü, Jie Li, Chen Yao, Guangqi Chang, Jiong Bi, Shenming Wang, Wenjian Wang

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Risk of cancer among HIV-infected patients from a population-based nested case–control study: implications for cancer prevention

Chang-Hua Chen, Chih-Yuan Chung, Li-Hsuan Wang, Che Lin, Hsiu-Li Lin, Hsiu-Chen Lin

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Cyproheptadine, an antihistaminic drug, inhibits proliferation of hepatocellular carcinoma cells by blocking cell cycle progression through the activation of P38 MAP kinase

Yu-Min Feng, Chin-Wen Feng, Syue-Yi Chen, Hsiao-Yen Hsieh, Yu-Hsin Chen, Cheng-Da Hsu

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Low levels of IGFBP7 expression in high-grade serous ovarian carcinoma is associated with patient outcome

Karen Gambaro, Michael CJ Quinn, Katia Y Cáceres-Gorriti, Rebecca S Shapiro, Diane Provencher, Kurosh Rahimi, Anne-Marie Mes-Masson, Patricia N Tonin

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Dose-response relationship in cisplatin-treated breast cancer xenografts monitored with dynamic contrast-enhanced ultrasound

Yao Chen, Feng Han, Long-hui Cao, Cheng Li, Jian-wei Wang, Qing Li, Wei Zheng, Zhi-xing Guo, An-hua Li, Jian-hua Zhou

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Alterations in anatomic and functional imaging parameters with repeated FDG PET-CT and MRI during radiotherapy for head and neck cancer: a pilot study

Manil Subesinghe, Andrew F Scarsbrook, Steven Sourbron, Daniel J Wilson, Garry McDermott, Richard Speight, Neil Roberts, Brendan Carey, Roan Forrester, Sandeep Vijaya Gopal, Jonathan R Sykes, Robin JD Prestwich

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Poor prognosis of single hormone receptor- positive breast cancer: similar outcome as triple-negative breast cancer

Soo Youn Bae, Sangmin Kim, Jun Ho Lee, Hyun-chul Lee, Se Kyung Lee, Won Ho Kil, Seok Won Kim, Jeong Eon Lee, Seok Jin Nam

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Annonaceous acetogenin mimic AA005 induces cancer cell death via apoptosis inducing factor through a caspase-3-independent mechanism

Bing Han, Tong-Dan Wang, Shao-Ming Shen, Yun Yu, Chan Mao, Zhu-Jun Yao, Li-Shun Wang

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Phosphorylation of pyruvate kinase M2 and lactate dehydrogenase A by fibroblast growth factor receptor 1 in benign and malignant thyroid tissue

Paul Kachel, Bogusz Trojanowicz, Carsten Sekulla, Hanna Prenzel, Henning Dralle, Cuong Hoang-Vu

01.12.2015 | Commentary | Ausgabe 1/2015 Open Access

Genomics driven-oncology: challenges and perspectives

Nicola Normanno, Ian A Cree

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Detection of morphologic alterations in rectal carcinoma following preoperative radiochemotherapy based on multiphoton microscopy imaging

Lianhuang Li, Zhifen Chen, Xingfu Wang, Hongsheng Li, Weizhong Jiang, Shuangmu Zhuo, Guoxian Guan, Jianxin Chen

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Associations between breast density and a panel of single nucleotide polymorphisms linked to breast cancer risk: a cohort study with digital mammography

Brad M Keller, Anne Marie McCarthy, Jinbo Chen, Katrina Armstrong, Emily F Conant, Susan M Domchek, Despina Kontos

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

HIV testing and burden of HIV infection in black cancer patients in Johannesburg, South Africa: a cross-sectional study

Mazvita Sengayi, Chantal Babb, Matthias Egger, Margaret I Urban

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Critical evaluation of Cbx7 downregulation in primary colon carcinomas and its clinical significance in Chinese patients

Xiang Zheng, Jing Zhou, Baozhen Zhang, Jun Zhang, James Wilson, Liankun Gu, Budong Zhu, Jin Gu, Jiafu Ji, Dajun Deng

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Prevalence and outcomes of extrahepatic primary malignancy associated with Hepatocellular Carcinoma in a Korean population

Sukho Hong, Sook-Hyang Jeong, Sang Soo Lee, Jung Wha Chung, Sung Wook Yang, Seong Min Chung, Eun Sun Jang, Jin-Wook Kim, Jee Hyun Kim, Haeryoung Kim, Jai Young Cho, Yoo-Seok Yoon, Ho-Seong Han

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

No significant viral transcription detected in whole breast cancer transcriptomes

Danai Fimereli, David Gacquer, Debora Fumagalli, Roberto Salgado, Françoise Rothé, Denis Larsimont, Christos Sotiriou, Vincent Detours

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Prognostic role of serum p53 antibodies in lung cancer

Manlio Mattioni, Silvia Soddu, Andrea Prodosmo, Paolo Visca, Salvatore Conti, Gabriele Alessandrini, Francesco Facciolo, Lidia Strigari

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Are urothelial carcinomas of the upper urinary tract a distinct entity from urothelial carcinomas of the urinary bladder? Behavior of urothelial carcinoma after radical surgery with respect to anatomical location: a case control study

Myong Kim, Chang Wook Jeong, Cheol Kwak, Hyeon Hoe Kim, Ja Hyeon Ku

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

NAT1 and NAT2 genetic polymorphisms and environmental exposure as risk factors for oesophageal squamous cell carcinoma: a case-control study

Marco Matejcic, Matjaz Vogelsang, Yabing Wang, Iqbal M Parker

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Cancers of unknown primary origin (CUP) are characterized by chromosomal instability (CIN) compared to metastasis of know origin

Jonas Vikeså, Anne Kirstine H Møller, Bogumil Kaczkowski, Rehannah Borup, Ole Winther, Ricardo Henao, Anders Krogh, Katharina Perell, Flemming Jensen, Gedske Daugaard, Finn C Nielsen

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Mechanisms of tumor-promoting activities of nicotine in lung cancer: synergistic effects of cell membrane and mitochondrial nicotinic acetylcholine receptors

Alex I Chernyavsky, Igor B Shchepotin, Valentin Galitovkiy, Sergei A Grando

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Total and partial cancer prevalence in the adult French population in 2008

Marc Colonna, Nicolas Mitton, Nadine Bossard, Aurelien Belot, Pascale Grosclaude, the French Network of Cancer Registries (FRANCIM)

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Efficacy of pazopanib monotherapy in patients who had been heavily pretreated for metastatic soft tissue sarcoma: a retrospective case series

Kwai Han Yoo, Hyo Song Kim, Su Jin Lee, Se Hoon Park, Sung Joo Kim, Soo Hee Kim, Yoon La Choi, Kyoo-Ho Shin, Yong Jin Cho, Jeeyun Lee, Sun Young Rha

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Prognostic relevance of positive urine markers in patients with negative cystoscopy during surveillance of bladder cancer

Tilman Todenhöfer, Jörg Hennenlotter, Philipp Guttenberg, Sarah Mohrhardt, Ursula Kuehs, Michael Esser, Stefan Aufderklamm, Simone Bier, Niklas Harland, Steffen Rausch, Georgios Gakis, Arnulf Stenzl, Christian Schwentner

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Systematic review of the predictive effect of MSI status in colorectal cancer patients undergoing 5FU-based chemotherapy

Elizabeth M Webber, Tia L Kauffman, Elizabeth O’Connor, Katrina AB Goddard

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

A mutation screening of oncogenes, tumor suppressor gene TP53 and nuclear encoded mitochondrial complex I genes in oncocytic thyroid tumors

Cecilia Evangelisti, Dario de Biase, Ivana Kurelac, Claudio Ceccarelli, Holger Prokisch, Thomas Meitinger, Paola Caria, Roberta Vanni, Giovanni Romeo, Giovanni Tallini, Giuseppe Gasparre, Elena Bonora

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Paired design study by real-time PCR: miR-378* and miR-145 are potent early diagnostic biomarkers of human colorectal cancer

Juan Peng, Zhengyong Xie, Liyang Cheng, Yuxin Zhang, Junyong Chen, Hongping Yu, Zehang Li, Huixing Kang

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Anticancer activity of a thymidine quinoxaline conjugate is modulated by cytosolic thymidine pathways

Qiong Wei, Haijuan Liu, Honghao Zhou, Dejun Zhang, Zhiwei Zhang, Qibing Zhou

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Heterogeneity analysis of Metastasis Associated in Colon Cancer 1 (MACC1) for survival prognosis of colorectal cancer patients: a retrospective cohort study

Viktor H Koelzer, Pia Herrmann, Inti Zlobec, Eva Karamitopoulou, Alessandro Lugli, Ulrike Stein

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Induction of tumor initiation is dependent on CD44s in c-Met+ hepatocellular carcinoma

Hien Dang, Steven N Steinway, Wei Ding, Carl B Rountree

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

The impact of supplementary narrative-based information on colorectal cancer screening beliefs and intention

Lesley M McGregor, Christian von Wagner, Gemma Vart, Wing Chee Yuen, Rosalind Raine, Jane Wardle, Kathryn A Robb

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Resolution of severe hyponatraemia is associated with improved survival in patients with cancer

Kirsty Balachandran, Alicia Okines, Ranga Gunapala, Daniel Morganstein, Sanjay Popat

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

The tumour-promoting receptor tyrosine kinase, EphB4, regulates expression of Integrin-β8 in prostate cancer cells

Inga Mertens-Walker, Bruno C Fernandini, Mohanan SN Maharaj, Anja Rockstroh, Colleen C Nelson, Adrian C Herington, Sally-Anne Stephenson

01.12.2015 | Study protocol | Ausgabe 1/2015 Open Access

The efficacy and safety of irreversible electroporation for the ablation of renal masses: a prospective, human, in-vivo study protocol

Peter GK Wagstaff, Daniel M de Bruin, Patricia J Zondervan, C Dilara Savci Heijink, Marc RW Engelbrecht, Otto M van Delden, Ton G van Leeuwen, Hessel Wijkstra, Jean JMCH de la Rosette, M Pilar Laguna Pes

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Overexpression of 17β-hydroxysteroid dehydrogenase type 10 increases pheochromocytoma cell growth and resistance to cell death

Emily A Carlson, Rebecca T Marquez, Fang Du, Yongfu Wang, Liang Xu, Shirley ShiDu Yan

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Identifying a low-risk group for parametrial involvement in microscopic Stage IB1 cervical cancer using criteria from ongoing studies and a new MRI criterion

Jung-Yun Lee, Jina Youm, Jae-Weon Kim, Jeong Yeon Cho, Min A Kim, Tae Hun Kim, Dong Hoon Suh, Myong Cheol Lim, Noh Hyun Park, Yong-Sang Song

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Prediction of long noncoding RNA functions with co-expression network in esophageal squamous cell carcinoma

Yibin Hao, Wei Wu, Fachun Shi, Rodrigo JS Dalmolin, Ming Yan, Fu Tian, Xiaobing Chen, Guoyong Chen, Wei Cao

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Transcriptional expression of 8 genes predicts pathological response to first-line docetaxel + trastuzumab-based neoadjuvant chemotherapy

Esther Schmitt, Frédérique Végran, Sandy Chevrier, Laura Burillier, Muriel Cadouot, Sarab Lizard-Nacol, Bruno Coudert, Pierre Fumoleau, Laurent Arnould, Romain Boidot

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

A novel engineered VEGF blocker with an excellent pharmacokinetic profile and robust anti-tumor activity

Lily Liu, Haijia Yu, Xin Huang, Hongzhi Tan, Song Li, Yan Luo, Li Zhang, Sumei Jiang, Huifeng Jia, Yao Xiong, Ruliang Zhang, Yi Huang, Charles C Chu, Wenzhi Tian

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

A retrospective analysis of RET translocation, gene copy number gain and expression in NSCLC patients treated with vandetanib in four randomized Phase III studies

Adam Platt, John Morten, Qunsheng Ji, Paul Elvin, Chris Womack, Xinying Su, Emma Donald, Neil Gray, Jessica Read, Graham Bigley, Laura Blockley, Carl Cresswell, Angela Dale, Amanda Davies, Tianwei Zhang, Shuqiong Fan, Haihua Fu, Amanda Gladwin, Grace Harrod, James Stevens, Victoria Williams, Qingqing Ye, Li Zheng, Richard de Boer, Roy S Herbst, Jin-Soo Lee, James Vasselli

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Ras induces experimental lung metastasis through up-regulation of RbAp46 to suppress RECK promoter activity

Hsuan-Heng Yeh, Yu-Fen Tseng, Yu-Chiao Hsu, Sheng-Hui Lan, Shan-Ying Wu, Giri Raghavaraju, Da-En Cheng, Ying-Ray Lee, Tsuey-Yu Chang, Nan-Haw Chow, Wen-Chun Hung, Hsiao-Sheng Liu

01.12.2015 | Erratum | Ausgabe 1/2015 Open Access

Erratum: Preoperative chemosensitivity testing as Predictor of Treatment benefit in Adjuvant stage III colon cancer (PePiTA): Protocol of a prospective BGDO (Belgian Group for Digestive Oncology) multicentric study

Alain Hendlisz, Vassilis Golfinopoulos, Amelie Deleporte, Marianne Paesmans, Hazem El Mansy, Camilo Garcia, Marc Peeters, Lieven Annemans, Caroline Vandeputte, Marion Maetens, Marc Van den Eynde, Raphaël Maréchal, Ivan Borbath, Damien Dresse, Ghislain Houbiers, Michael Fried, Ahmad Awada, Martine Piccart, Jean-Luc Van Laethem, Patrick Flamen

01.12.2015 | Research | Ausgabe 1/2015 Open Access

Photodynamic diagnosis of pleural malignant lesions with a combination of 5-aminolevulinic acid and intrinsic fluorescence observation systems

Masahiro Kitada, Yoshinobu Ohsaki, Yoshinari Matsuda, Satoshi Hayashi, Kei Ishibashi

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

A retrospective chart review of drug treatment patterns and clinical outcomes among patients with metastatic or recurrent soft tissue sarcoma refractory to one or more prior chemotherapy treatments

Michael J Wagner, Leo Ismaila Amodu, Mei Sheng Duh, Caroline Korves, Franco Solleza, Stephanie C Manson, José Diaz, Maureen P Neary, George D Demetri

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Multicenter phase II study of FOLFIRI plus bevacizumab after discontinuation of oxaliplatin-based regimen for advanced or recurrent colorectal cancer (CR0802)

Mitsukuni Suenaga, Tomohiro Nishina, Nobuyuki Mizunuma, Hisateru Yasui, Takashi Ura, Tadamichi Denda, Junichi Ikeda, Taito Esaki, Hogara Nishisaki, Yoshinao Takano, Yasuyuki Sugiyama, Kei Muro

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Dietary cadmium intake and risk of prostate cancer: a Danish prospective cohort study

Kirsten T Eriksen, Jytte Halkjær, Jaymie R Meliker, Jane A McElroy, Mette Sørensen, Anne Tjønneland, Ole Raaschou-Nielsen

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Epithelial-mesenchymal plasticity is a decisive feature for the metastatic outgrowth of disseminated WAP-T mouse mammary carcinoma cells

Claudia Maenz, Eva Lenfert, Klaus Pantel, Udo Schumacher, Wolfgang Deppert, Florian Wegwitz

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Evaluation of public cancer datasets and signatures identifies TP53 mutant signatures with robust prognostic and predictive value

Brian David Lehmann, Yan Ding, Daniel Joseph Viox, Ming Jiang, Yi Zheng, Wang Liao, Xi Chen, Wei Xiang, Yajun Yi

01.12.2015 | Study protocol | Ausgabe 1/2015 Open Access

Neo-adjuvant chemotherapy followed by surgery versus surgery alone in high-risk patients with resectable colorectal liver metastases: the CHARISMA randomized multicenter clinical trial

Ninos Ayez, Eric P van der Stok, Hans de Wilt, Sandra A Radema, Richard van Hillegersberg, Rudi M Roumen, Gerard Vreugdenhil, Pieter J Tanis, Cornelis J Punt, Cornelis H Dejong, Rob L Jansen, Henk M Verheul, Koert P de Jong, Geke A Hospers, Joost M Klaase, Marie-Cecile Legdeur, Esther van Meerten, Ferry A Eskens, Nelly van der Meer, Bruno van der Holt, Cornelis Verhoef, Dirk J Grünhagen

01.12.2015 | Case report | Ausgabe 1/2015 Open Access

BRCA1 germline mutation and glioblastoma development: report of cases

Meriem Boukerroucha, Claire Josse, Karin Segers, Sonia El-Guendi, Pierre Frères, Guy Jerusalem, Vincent Bours

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Low mir-372 expression correlates with poor prognosis and tumor metastasis in hepatocellular carcinoma

Gang Wu, Yawei Wang, Xiaojun Lu, Hui He, Haiyang Liu, Xiangyu Meng, Shuguan Xia, Kunming Zheng, Boqian Liu

01.12.2015 | Case report | Ausgabe 1/2015 Open Access

Breast cancer and neurofibromatosis type 1: a diagnostic challenge in patients with a high number of neurofibromas

André Vallejo Da Silva, Fabiana Resende Rodrigues, Mônica Pureza, Vania Gloria Silami Lopes, Karin Soares Cunha

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Sorafenib inhibits intracellular signaling pathways and induces cell cycle arrest and cell death in thyroid carcinoma cells irrespective of histological origin or BRAF mutational status

Martina Broecker-Preuss, Stefan Müller, Martin Britten, Karl Worm, Kurt Werner Schmid, Klaus Mann, Dagmar Fuhrer

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

A population-based study of incidence and patient survival of small cell carcinoma in the United States, 1992–2010

Graça M Dores, Osama Qubaiah, Ankur Mody, Bassam Ghabach, Susan S Devesa

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Factors influencing participation in a randomized controlled resistance exercise intervention study in breast cancer patients during radiotherapy

Sandra M Gollhofer, Joachim Wiskemann, Martina E Schmidt, Oliver Klassen, Cornelia M Ulrich, Jan Oelmann, Holger Hof, Karin Potthoff, Karen Steindorf

01.12.2015 | Retraction Note | Ausgabe 1/2015 Open Access

Retraction Note: STMN-1 is a potential marker of lymph node metastasis in distal esophageal adenocarcinomas and silencing its expression can reverse malignant phenotype of tumor cells

Javed Akhtar, Zhou Wang, Che Yu, Chen-Sheng Li, Yu-Long Shi, Hong-Jun Liu

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

The role of multipotent cancer associated fibroblasts in hepatocarcinogenesis

Caecilia Hapsari Ceriapuri Sukowati, Beatrice Anfuso, Lory Saveria Crocé, Claudio Tiribelli

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

NPC1L1 knockout protects against colitis-associated tumorigenesis in mice

Jianming He, Hyunsu Shin, Xing Wei, Anil Kumar G Kadegowda, Rui Chen, Sandy Krystal Xie

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

The role of androgen deprivation therapy on biochemical failure and distant metastasis in intermediate-risk prostate cancer: effects of radiation dose escalation

Michelle S Ludwig, Deborah A Kuban, Xianglin L Du, David S Lopez, Jose-Miguel Yamal, Sara S Strom

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Residential environment and breast cancer incidence and mortality: a systematic review and meta-analysis

Tomi F Akinyemiju, Jeanine M Genkinger, Maggie Farhat, Adrienne Wilson, Tiffany L Gary-Webb, Parisa Tehranifar

01.12.2015 | Study protocol | Ausgabe 1/2015 Open Access

Ion therapy within the trimodal management of superior sulcus tumors: the INKA trial

Henrik Hauswald, Stefan Rieken, Hendrik C Dienemann, Michael Thomas, Meinhard Kieser, Jürgen Debus, Klaus Herfarth

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Feasibility of urinary microRNA detection in breast cancer patients and its potential as an innovative non-invasive biomarker

Thalia Erbes, Marc Hirschfeld, Gerta Rücker, Markus Jaeger, Jasmin Boas, Severine Iborra, Sebastian Mayer, Gerald Gitsch, Elmar Stickeler

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Association between CHEK2 H371Y mutation and response to neoadjuvant chemotherapy in women with breast cancer

Yin Liu, Ye Xu, Tao Ouyang, Jinfeng Li, Tianfeng Wang, Zhaoqing Fan, Tie Fan, Benyao Lin, Yuntao Xie

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Pre-treatment neutrophil to lymphocyte ratio may be a useful tool in predicting survival in early triple negative breast cancer patients

Mirco Pistelli, Mariagrazia De Lisa, Zelmira Ballatore, Miriam Caramanti, Alessandra Pagliacci, Nicola Battelli, Francesca Ridolfi, Matteo Santoni, Elena Maccaroni, Raffaella Bracci, Alfredo Santinelli, Tommasina Biscotti, Rossana Berardi, Stefano Cascinu

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Topotecan synergizes with CHEK1 (CHK1) inhibitor to induce apoptosis in ovarian cancer cells

Marianne K Kim, Jana James, Christina M Annunziata

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Sumoylation of Kif18A plays a role in regulating mitotic progression

Feikun Yang, Yan Chen, Wei Dai

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Prognostic significance of interim PET/CT based on visual, SUV-based, and MTV-based assessment in the treatment of peripheral T-cell lymphoma

Sung-Hoon Jung, Jae-Sook Ahn, Yeo-Kyeoung Kim, Sun-Seog Kweon, Jung-Joon Min, Hee-Seung Bom, Hyeoung-Joon Kim, Yee Soo Chae, Joon Ho Moon, Sang Kyun Sohn, Sang Woo Lee, Byung Hyun Byun, Young Rok Do, Je-Jung Lee, Deok-Hwan Yang

01.12.2015 | Technical advance | Ausgabe 1/2015 Open Access

A multiplexed, targeted mass spectrometry assay of the S100 protein family uncovers the isoform-specific expression in thyroid tumours

Juan Martínez-Aguilar, Roderick Clifton-Bligh, Mark P Molloy

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

The leukemia inhibitory factor (LIF) and p21 mediate the TGFβ tumor suppressive effects in human cutaneous melanoma

Laure Humbert, Mostafa Ghozlan, Lucie Canaff, Jun Tian, Jean-Jacques Lebrun

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Luminal B subtype: A key factor for the worse prognosis of young breast cancer patients in China

Li-Chen Tang, Xi Jin, Hai-Yuan Yang, Min He, Helena Chang, Zhi-Ming Shao, Gen-Hong Di

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Meta-analysis of the prognostic value of circulating tumor cells detected with the CellSearch System in colorectal cancer

Xuanzhang Huang, Peng Gao, Yongxi Song, Jingxu Sun, Xiaowan Chen, Junhua Zhao, Huimian Xu, Zhenning Wang

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

MTUS1/ATIP3a down-regulation is associated with enhanced migration, invasion and poor prognosis in salivary adenoid cystic carcinoma

Tingting Zhao, Xueqiang Ding, Boyang Chang, Xiaofeng Zhou, Anxun Wang

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Androgen receptor and chemokine receptors 4 and 7 form a signaling axis to regulate CXCL12-dependent cellular motility

Jordy J Hsiao, Brandon H Ng, Melinda M Smits, Jiahui Wang, Rohini J Jasavala, Harryl D Martinez, Jinhee Lee, Jhullian J Alston, Hiroaki Misonou, James S Trimmer, Michael E Wright

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Homozygous deletions of UGT2B17 modifies effects of smoking on TP53-mutations and relapse of head and neck carcinoma

Aki Mafune, Takanori Hama, Toshihito Suda, Yutaka Suzuki, Masahiro Ikegami, Chikako Sakanashi, Satoko Imai, Akio Nakashima, Takashi Yokoo, Kota Wada, Hiromi Kojima, Mitsuyoshi Urashima

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Circulating tumor cells in hepatocellular carcinoma: a pilot study of detection, enumeration, and next-generation sequencing in cases and controls

Robin K Kelley, Mark Jesus M Magbanua, Timothy M Butler, Eric A Collisson, Jimmy Hwang, Nikoletta Sidiropoulos, Kimberley Evason, Ryan M McWhirter, Bilal Hameed, Elizabeth M Wayne, Francis Y Yao, Alan P Venook, John W Park

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

NQO1 protein expression predicts poor prognosis of non-small cell lung cancers

Zhenling Li, Yue Zhang, Tiefeng Jin, Jiguang Men, Zhenhua Lin, Peng Qi, Yingshi Piao, Guanghai Yan

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Murine double minute 2 predicts response of advanced esophageal squamous cell carcinoma to definitive chemoradiotherapy

Hiroshi Okamoto, Fumiyoshi Fujishima, Takashi Kamei, Yasuhiro Nakamura, Yohei Ozawa, Go Miyata, Toru Nakano, Kazunori Katsura, Shigeo Abe, Yusuke Taniyama, Tadashi Sakurai, Jin Teshima, Makoto Hikage, Hironobu Sasano, Noriaki Ohuchi

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Prognostic value of carbonic anhydrase VII expression in colorectal carcinoma

Guang-Zhen Yang, Liang Hu, Jian Cai, Hai-Yang Chen, Yu Zhang, Dan Feng, Chen-Ye Qi, Yan-Xia Zhai, Hui Gong, Hao Fu, Qing-Ping Cai, Chun-Fang Gao

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Treatment and survival of non-alcoholic steatohepatitis associated hepatocellular carcinoma

Arndt Weinmann, Yvonne Alt, Sandra Koch, Carina Nelles, Christoph Düber, Hauke Lang, Gerd Otto, Tim Zimmermann, Jens U Marquardt, Peter R Galle, Marcus A Wörns, Jörn M Schattenberg

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Effects of payer status on breast cancer survival: a retrospective study

Runhua Shi, Hannah Taylor, Jerry McLarty, Lihong Liu, Glenn Mills, Gary Burton

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Lack of a protective effect of cotton dust on risk of lung cancer: evidence from two population-based case-control studies

Krista Yorita Christensen, Jérôme Lavoué, Marie-Claude Rousseau, Jack Siemiatycki

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Sentinel lymph node detection using magnetic resonance lymphography with conventional gadolinium contrast agent in breast cancer: a preliminary clinical study

Chuanming Li, Shan Meng, Xinhua Yang, Daiquan Zhou, Jian Wang, Jiani Hu

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Availability and outcomes of radiotherapy in Central Poland during the 2005-2012 period - an observational study

Justyna Chalubinska-Fendler, Wojciech Fendler, Michal Spych, Jolanta Luniewska-Bury, Wojciech Mlynarski, Jacek Fijuth

01.12.2015 | Technical advance | Ausgabe 1/2015 Open Access

Development and analytical validation of a 25-gene next generation sequencing panel that includes the BRCA1 and BRCA2 genes to assess hereditary cancer risk

Thaddeus Judkins, Benoît Leclair, Karla Bowles, Natalia Gutin, Jeff Trost, James McCulloch, Satish Bhatnagar, Adam Murray, Jonathan Craft, Bryan Wardell, Mark Bastian, Jeffrey Mitchell, Jian Chen, Thanh Tran, Deborah Williams, Jennifer Potter, Srikanth Jammulapati, Michael Perry, Brian Morris, Benjamin Roa, Kirsten Timms

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Comparison of analytical and clinical performance of CLART HPV2 genotyping assay to Linear Array and Hybrid Capture 2: a split-sample study

Ditte Møller Ejegod, Matejka Rebolj, Jesper Bonde

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Direct confirmation of quiescence of CD34+CD38- leukemia stem cell populations using single cell culture, their molecular signature and clinicopathological implications

Eun Jeong Won, Hye-Ran Kim, Ra-Young Park, Seok-Yong Choi, Jong Hee Shin, Soon-Pal Suh, Dong-Wook Ryang, Michael Szardenings, Myung-Geun Shin

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Improvement of the initial management of sarcomas after the dissemination of evidence-based guidelines depends on the primary sarcoma location: a population-based study

Karine Ligier, Carlos Maynou, Xavier Leroy, Yves-Marie Robin, Philippe Martin, Stéphanie Clisant, Florence Richard, Nicolas Penel

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

BRCA1 Alternative splicing landscape in breast tissue samples

Atocha Romero, Francisco García-García, Irene López-Perolio, Gorka Ruiz de Garibay, José A García-Sáenz, Pilar Garre, Patricia Ayllón, Esperanza Benito, Joaquín Dopazo, Eduardo Díaz-Rubio, Trinidad Caldés, Miguel de la Hoya

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

The role of histologic subtype, p16INK4a expression, and presence of human papillomavirus DNA in penile squamous cell carcinoma

Julie Steinestel, Andreas Al Ghazal, Annette Arndt, Thomas J Schnoeller, Andres J Schrader, Peter Moeller, Konrad Steinestel

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

A pooled shRNA screen for regulators of primary mammary stem and progenitor cells identifies roles for Asap1 and Prox1

Julie M Sheridan, Matthew E Ritchie, Sarah A Best, Kun Jiang, Tamara J Beck, François Vaillant, Kevin Liu, Ross A Dickins, Gordon K Smyth, Geoffrey J Lindeman, Jane E Visvader

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Abiraterone acetate in patients with metastatic castration-resistant prostate cancer: long term outcome of the Temporary Authorization for Use programme in France

Nadine Houédé, Philippe Beuzeboc, Sophie Gourgou, Diego Tosi, Laura Moise, Gwenaëlle Gravis, Remy Delva, Aude Fléchon, Igor Latorzeff, Jean-Marc Ferrero, Stéphane Oudard, Sophie Tartas, Brigitte Laguerre, Delphine Topart, Guilhem Roubaud, Hanane Agherbi, Xavier Rebillard, David Azria

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Human pancreatic cancer stem cells are sensitive to dual inhibition of IGF-IR and ErbB receptors

Nerea Urtasun, Anna Vidal-Pla, Sandra Pérez-Torras, Adela Mazo

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Chemoresistance is associated with increased cytoprotective autophagy and diminished apoptosis in bladder cancer cells treated with the BH3 mimetic (−)-Gossypol (AT-101)

Jens Mani, Stefan Vallo, Stefanie Rakel, Patrick Antonietti, Florian Gessler, Roman Blaheta, Georg Bartsch, Martin Michaelis, Jindrich Cinatl, Axel Haferkamp, Donat Kögel

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

γ-Glutamyl transferase 7 is a novel regulator of glioblastoma growth

Timothy T Bui, Ryan T Nitta, Suzana A Kahn, Seyed-Mostafa Razavi, Maya Agarwal, Parvir Aujla, Sharareh Gholamin, Lawrence Recht, Gordon Li

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Tenovin-6-mediated inhibition of SIRT1/2 induces apoptosis in acute lymphoblastic leukemia (ALL) cells and eliminates ALL stem/progenitor cells

Yanli Jin, Qi Cao, Chun Chen, Xin Du, Bei Jin, Jingxuan Pan

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Role of the splicing factor SRSF4 in cisplatin-induced modifications of pre-mRNA splicing and apoptosis

Maude Gabriel, Yves Delforge, Adeline Deward, Yvette Habraken, Benoit Hennuy, Jacques Piette, Roscoe Klinck, Benoit Chabot, Alain Colige, Charles Lambert

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

In vitro and in vivo antiproliferative activity of metformin on stem-like cells isolated from spontaneous canine mammary carcinomas: translational implications for human tumors

Federica Barbieri, Stefano Thellung, Alessandra Ratto, Elisa Carra, Valeria Marini, Carmen Fucile, Adriana Bajetto, Alessandra Pattarozzi, Roberto Würth, Monica Gatti, Chiara Campanella, Guendalina Vito, Francesca Mattioli, Aldo Pagano, Antonio Daga, Angelo Ferrari, Tullio Florio

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

HNF1B polymorphism influences the prognosis of endometrial cancer patients: a cohort study

Vincenzo Dario Mandato, Enrico Farnetti, Federica Torricelli, Martino Abrate, Bruno Casali, Gino Ciarlini, Debora Pirillo, Maria Carolina Gelli, Davide Nicoli, Mario Grassi, Giovanni Battista LA Sala, Stefano Palomba

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

HPV-16 impairs the subcellular distribution and levels of expression of protein phosphatase 1γ in cervical malignancy

Takayuki Seiki, Kazunori Nagasaka, Christian Kranjec, Kei Kawana, Daichi Maeda, Hiroe Nakamura, Ayumi Taguchi, Yoko Matsumoto, Takahide Arimoto, Osamu Wada-Hiraike, Katsutoshi Oda, Shunsuke Nakagawa, Tetsu Yano, Masashi Fukayama, Lawrence Banks, Yutaka Osuga, Tomoyuki Fujii

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Changing the clinical course of glioma patients by preoperative motor mapping with navigated transcranial magnetic brain stimulation

Sandro M Krieg, Nico Sollmann, Thomas Obermueller, Jamil Sabih, Lucia Bulubas, Chiara Negwer, Tobias Moser, Doris Droese, Tobias Boeckh-Behrens, Florian Ringel, Bernhard Meyer

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Effect of liver transplantation in combined hepatocellular and cholangiocellular carcinoma: a case series

Di Wu, Zhong-Yang Shen, Ya-Min Zhang, Jian Wang, Hong Zheng, Yong-Lin Deng, Cheng Pan

01.12.2015 | Study protocol | Ausgabe 1/2015 Open Access

eCROPS-CA: a systematic approach toward effective and sustainable cancer prevention in rural China

Jing Chai, Xingrong Shen, Rui Feng, Jing Cheng, Yeji Chen, Zhengqiu Zha, Shangchun Jia, Han Liang, Ting Zhao, Rui Sha, Yong Shi, Kaichun Li, Debin Wang

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Vascular dysfunction and increased metastasis of B16F10 melanomas in Shb deficient mice as compared with their wild type counterparts

Guangxiang Zang, Karin Gustafsson, Maria Jamalpour, JongWook Hong, Guillem Genové, Michael Welsh

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Predicting response to multidrug regimens in cancer patients using cell line experiments and regularised regression models

Steffen Falgreen, Karen Dybkær, Ken H Young, Zijun Y Xu-Monette, Tarec C El-Galaly, Maria Bach Laursen, Julie S Bødker, Malene K Kjeldsen, Alexander Schmitz, Mette Nyegaard, Hans Erik Johnsen, Martin Bøgsted

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Clinical outcomes of patients with advanced hepatocellular carcinoma treated with sorafenib: a retrospective study of routine clinical practice in multi-institutions

Sae Hwan Lee, Il Han Song, Ran Noh, Ha Yan Kang, Suk Bae Kim, Soon Young Ko, Eoum Seok Lee, Seok Hyun Kim, Byung Seok Lee, An Na Kim, Hee Bok Chae, Hong Soo Kim, Tae Hee Lee, Young Woo Kang, Jae Dong Lee, Heon Young Lee

01.12.2015 | Study protocol | Ausgabe 1/2015 Open Access

Treatment of advanced gastrointestinal tumors with genetically modified autologous mesenchymal stromal cells (TREAT-ME1): study protocol of a phase I/II clinical trial

Hanno Niess, Jobst C von Einem, Michael N Thomas, Marlies Michl, Martin K Angele, Ralf Huss, Christine Günther, Peter J Nelson, Christiane J Bruns, Volker Heinemann

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

MicroRNA-223 is a novel negative regulator of HSP90B1 in CLL

Ana E Rodríguez-Vicente, Dalia Quwaider, Rocío Benito, Irena Misiewicz-Krzeminska, María Hernández-Sánchez, Alfonso García de Coca, Rosa Fisac, José-María Alonso, Carolina Zato, Juan Francisco de Paz, Juan Luis García, Ma Eugenia Sarasquete, José Ángel Hernández, Juan M Corchado, Marcos González, Norma C Gutiérrez, Jesús-María Hernández-Rivas

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Aurora kinase B is important for antiestrogen resistant cell growth and a potential biomarker for tamoxifen resistant breast cancer

Sarah L Larsen, Christina W Yde, Anne-Vibeke Laenkholm, Birgitte B Rasmussen, Anne Katrine Duun-Henriksen, Martin Bak, Anne E Lykkesfeldt, Tove Kirkegaard

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

HGUE-C-1 is an atypical and novel colon carcinoma cell line

Silvina Grasso, Isabel Martínez-Lacaci, Víctor Manuel Barberá, Adela Castillejo, José Luis Soto, Javier Gallego-Plazas, Natividad López-Riquelme, Pilar García-Morales, Trinidad Mata-Balaguer, José Antonio Ferragut, Miguel Saceda

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Control of the MYC-eIF4E axis plus mTOR inhibitor treatment in small cell lung cancer

Masaru Matsumoto, Masahiro Seike, Rintaro Noro, Chie Soeno, Teppei Sugano, Susumu Takeuchi, Akihiko Miyanaga, Kazuhiro Kitamura, Kaoru Kubota, Akihiko Gemma

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

DNA copy number analysis of metastatic urothelial carcinoma with comparison to primary tumors

Richard M Bambury, Ami S Bhatt, Markus Riester, Chandra Sekhar Pedamallu, Fujiko Duke, Joaquim Bellmunt, Edward C Stack, Lillian Werner, Rachel Park, Gopa Iyer, Massimo Loda, Philip W Kantoff, Franziska Michor, Matthew Meyerson, Jonathan E Rosenberg

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

General Practitioners and Breast Surgeons in France, Germany, Netherlands and the UK show variable breast cancer risk communication profiles

Claire Julian-Reynier, Anne-Deborah Bouhnik, D Gareth Evans, Hilary Harris, Christi J van Asperen, Aad Tibben, Joerg Schmidtke, Irmgard Nippert

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

High expression of NQO1 is associated with poor prognosis in serous ovarian carcinoma

Xuelian Cui, Lianhua Li, Guanghai Yan, Kai Meng, Zhenhua Lin, Yunze Nan, Guang Jin, Chunyu Li

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

TLR3 expression correlates with apoptosis, proliferation and angiogenesis in hepatocellular carcinoma and predicts prognosis

Ming-Ming Yuan, Yu-Yin Xu, Li Chen, Xing-Yu Li, Jing Qin, Ying Shen

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Serine threonine tyrosine kinase 1 is a potential prognostic marker in colorectal cancer

Liang Hu, Hai-Yang Chen, Jian Cai, Yu Zhang, Chen-Ye Qi, Hui Gong, Yan-Xia Zhai, Hao Fu, Guang-Zhen Yang, Chun-Fang Gao

01.12.2015 | Case report | Ausgabe 1/2015 Open Access

Oxaliplatin toxicity presenting as a liver nodule – case report

Henrique Alexandrino, Domingos Oliveira, Maria Augusta Cipriano, Luís Ferreira, J Guilherme Tralhão, Francisco Castro e Sousa

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Oridonin stabilizes retinoic acid receptor alpha through ROS-activated NF-κB signaling

Yang Cao, Wei Wei, Nan Zhang, Qing Yu, Wen-Bin Xu, Wen-Jun Yu, Guo-Qiang Chen, Ying-Li Wu, Hua Yan

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Characteristics of attitude and recommendation of oncologists toward exercise in South Korea: a cross sectional survey study

Ji-Hye Park, Minsuk Oh, Yong Jin Yoon, Chul Won Lee, Lee W Jones, Seung Il Kim, Nam Kyu Kim, Justin Y Jeon

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Curcumin potentiates antitumor activity of 5-fluorouracil in a 3D alginate tumor microenvironment of colorectal cancer

Mehdi Shakibaei, Patricia Kraehe, Bastian Popper, Parviz Shayan, Ajay Goel, Constanze Buhrmann

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Combined comparative genomic hybridization and transcriptomic analyses of ovarian granulosa cell tumors point to novel candidate driver genes

Sandrine Caburet, Mikko Anttonen, Anne-Laure Todeschini, Leila Unkila-Kallio, Denis Mestivier, Ralf Butzow, Reiner A Veitia

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Confocal laser endomicroscopy in breast surgery: a pilot study

Giovanni D De Palma, Dario Esposito, Gaetano Luglio, Gennaro Limite, Antonello Accurso, Viviana Sollazzo, Francesco Maione, Gianluca Cassese, Saverio Siciliano, Nicola Gennarelli, Gennaro Ilardi, Mariano Paternoster, Mariano C Giglio, Pietro Forestieri

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Safety and feasibility of adjuvant chemotherapy with S-1 in Japanese breast cancer patients after primary systemic chemotherapy: a feasibility study

Takashi Shigekawa, Akihiko Osaki, Hiroshi Sekine, Nobuaki Sato, Chizuko Kanbayashi, Hiroshi Sano, Hideki Takeuchi, Shigeto Ueda, Noriko Nakamiya, Ikuko Sugitani, Michiko Sugiyama, Hiroko Shimada, Eiko Hirokawa, Takao Takahashi, Toshiaki Saeki

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

The natural compound Guttiferone F sensitizes prostate cancer to starvation induced apoptosis via calcium and JNK elevation

Xin Li, Yuanzhi Lao, Hong Zhang, Xiaoyu Wang, Hongsheng Tan, Zhixiu Lin, Hongxi Xu

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Combined treatment of Nimotuzumab and rapamycin is effective against temozolomide-resistant human gliomas regardless of the EGFR mutation status

Dawn Q Chong, Xin Y Toh, Ivy AW Ho, Kian C Sia, Jennifer P Newman, Yulyana Yulyana, Wai-Hoe Ng, Siang H Lai, Mac MF Ho, Nivedh Dinesh, Chee K Tham, Paula YP Lam

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Remodeling of extracellular matrix by normal and tumor-associated fibroblasts promotes cervical cancer progression

Alexandra Fullár, József Dudás, Lászlóné Oláh, Péter Hollósi, Zoltán Papp, Gábor Sobel, Katalin Karászi, Sándor Paku, Kornélia Baghy, Ilona Kovalszky

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Long-term follow-up results of simultaneous integrated or late course accelerated boost with external beam radiotherapy to vaginal cuff for high risk cervical cancer patients after radical hysterectomy

Xin Wang, Yaqin Zhao, Yali Shen, Pei Shu, Zhiping Li, Sen Bai, Feng Xu

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

A retrospective observational study of clinicopathological features of KRAS, NRAS, BRAF and PIK3CA mutations in Japanese patients with metastatic colorectal cancer

Akihito Kawazoe, Kohei Shitara, Shota Fukuoka, Yasutoshi Kuboki, Hideaki Bando, Wataru Okamoto, Takashi Kojima, Nozomu Fuse, Takeharu Yamanaka, Toshihiko Doi, Atsushi Ohtsu, Takayuki Yoshino

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Novel non-invasive biomarkers that distinguish between benign prostate hyperplasia and prostate cancer

Andrej Jedinak, Adam Curatolo, David Zurakowski, Simon Dillon, Manoj K Bhasin, Towia A Libermann, Roopali Roy, Monisha Sachdev, Kevin R Loughlin, Marsha A Moses

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Identification of a unique hepatocellular carcinoma line, Li-7, with CD13(+) cancer stem cells hierarchy and population change upon its differentiation during culture and effects of sorafenib

Takeshi Yamada, Masato Abei, Inaho Danjoh, Ryoko Shirota, Taro Yamashita, Ichinosuke Hyodo, Yukio Nakamura

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

The impact of preoperative language mapping by repetitive navigated transcranial magnetic stimulation on the clinical course of brain tumor patients

Nico Sollmann, Sebastian Ille, Theresa Hauck, Stefanie Maurer, Chiara Negwer, Claus Zimmer, Florian Ringel, Bernhard Meyer, Sandro M Krieg

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Cyclin D1 sensitizes myeloma cells to endoplasmic reticulum stress-mediated apoptosis by activating the unfolded protein response pathway

Sophie Bustany, Julie Cahu, Philippe Guardiola, Brigitte Sola

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

The role of clinically significant portal hypertension in hepatic resection for hepatocellular carcinoma patients: a propensity score matching analysis

Wei He, Qingli Zeng, Yun Zheng, Meixian Chen, Jingxian Shen, Jiliang Qiu, Miao Chen, Ruhai Zou, Yadi Liao, Qijiong Li, Xianqiu Wu, Binkui Li, Yunfei Yuan

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Copy number gain of granulin-epithelin precursor (GEP) at chromosome 17q21 associates with overexpression in human liver cancer

Man Kuen Yung, Kwok Wai Lo, Chi Wai Yip, Grace TY Chung, Carol YK Tong, Phyllis FY Cheung, Tan To Cheung, Ronnie TP Poon, Samuel So, Sheung Tat Fan, Siu Tim Cheung

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Feasibility of self-sampled dried blood spot and saliva samples sent by mail in a population-based study

Amrit Kaur Sakhi, Nasser Ezzatkhah Bastani, Merete Ellingjord-Dale, Thomas Erik Gundersen, Rune Blomhoff, Giske Ursin

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

The involvement of insulin-like growth factor 2 binding protein 3 (IMP3) in pancreatic cancer cell migration, invasion, and adhesion

Clarissa C Pasiliao, Che-Wei A Chang, Brent W Sutherland, Shannon M Valdez, David Schaeffer, Donald T Yapp, Sylvia S W Ng

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Pro1170 Ala polymorphism in HER2-neu is associated with risk of trastuzumab cardiotoxicity

Sasha E Stanton, Maureen M Ward, Paul Christos, Rachel Sanford, Christina Lam, Marta V Cobham, Diana Donovan, Ronald J Scheff, Tessa Cigler, Anne Moore, Linda T Vahdat, Maureen E Lane, Ellen Chuang

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Perceived causes and consequences of sexual changes after cancer for women and men: a mixed method study

Jane M Ussher, Janette Perz, Emilee Gilbert, The Australian Cancer and Sexuality Study Team

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Gangliocytic paraganglioma: a multi-institutional retrospective study in Japan

Yoichiro Okubo, Tetsuo Nemoto, Megumi Wakayama, Naobumi Tochigi, Minoru Shinozaki, Takao Ishiwatari, Kyoko Aki, Masaru Tsuchiya, Hajime Aoyama, Kanade Katsura, Takeshi Fujii, Takashi Nishigami, Tomoyuki Yokose, Yasuo Ohkura, Kazutoshi Shibuya

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Management and prognosis of patients with ovarian sex cord tumor with annular tubules: a retrospective study

Qiuhong Qian, Yan You, Jiaxin Yang, Dongyan Cao, Zhaohui Zhu, Ming Wu, Jie Chen, Jinghe Lang, Keng Shen

01.12.2015 | Case report | Ausgabe 1/2015 Open Access

Colorectal liver metastases: making the unresectable resectable using irreversible electroporation for microscopic positive margins – a case report

Hans F Schoellhammer, Bryan Goldner, Shaila J Merchant, Jonathan Kessler, Yuman Fong, Singh Gagandeep

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Lower PRDM2 expression is associated with dopamine-agonist resistance and tumor recurrence in prolactinomas

Hua Gao, Fei Wang, Xiaolei Lan, Chuzhong Li, Jie Feng, Jiwei Bai, Lei Cao, Songbai Gui, Lichuan Hong, Yazhuo Zhang

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

DNA methylation and histone modifications regulate SOX11 expression in lymphoid and solid cancer cells

Lena Nordström, Elin Andersson, Venera Kuci, Elin Gustavsson, Karolina Holm, Markus Ringnér, Per Guldberg, Sara Ek

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Inter-observer agreement according to three methods of evaluating mammographic density and parenchymal pattern in a case control study: impact on relative risk of breast cancer

Rikke Rass Winkel, My von Euler-Chelpin, Mads Nielsen, Pengfei Diao, Michael Bachmann Nielsen, Wei Yao Uldall, Ilse Vejborg

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Loss of AF-6/afadin induces cell invasion, suppresses the formation of glandular structures and might be a predictive marker of resistance to chemotherapy in endometrial cancer

Takuro Yamamoto, Taisuke Mori, Morio Sawada, Hiroshi Matsushima, Fumitake Ito, Makoto Akiyama, Jo Kitawaki

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Discovery and anti-cancer evaluation of two novel non-ATP-competitive FGFR1 inhibitors in non-small-cell lung cancer

Jianzhang Wu, Tao Wei, Qinqin Tang, Bixia Weng, Wulan Li, Xin Jiang, Ting Ding, Xiaokun Li, Guang Liang, Yuepiao Cai, Jiansong Ji

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

ACTN4 and the pathways associated with cell motility and adhesion contribute to the process of lung cancer metastasis to the brain

Yufei Gao, Guanghu Li, Liankun Sun, Yichun He, Xiaoyan Li, Zhi Sun, Jihan Wang, Yang Jiang, Jingwei Shi

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Association of high obesity with PAM50 breast cancer intrinsic subtypes and gene expression

Marilyn L Kwan, Candyce H Kroenke, Carol Sweeney, Philip S Bernard, Erin K Weltzien, Adrienne Castillo, Rachel E Factor, Kaylynn S Maxfield, Inge J Stijleman, Lawrence H Kushi, Charles P Quesenberry Jr., Laurel A Habel, Bette J Caan

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

The implementation of an organised cervical screening programme in Poland: an analysis of the adherence to European guidelines

Andrzej Nowakowski, Marek Cybulski, Andrzej Śliwczyński, Arkadiusz Chil, Zbigniew Teter, Przemysław Seroczyński, Marc Arbyn, Ahti Anttila

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Improving the assessment of quality of life in the clinical care of myeloma patients: the development and validation of the Myeloma Patient Outcome Scale (MyPOS)

Thomas R Osborne, Christina Ramsenthaler, Stephen A Schey, Richard J Siegert, Polly M Edmonds, Irene J Higginson

01.12.2015 | Study protocol | Ausgabe 1/2015 Open Access

Multiparametric MRI as an outcome predictor for anal canal cancer managed with chemoradiotherapy

Michael Jones, George Hruby, Peter Stanwell, Sarah Gallagher, Karen Wong, Jameen Arm, Jarad Martin

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Clinicopathological study of centrally necrotizing carcinoma of the breast

Yanling Zhang, Yurong Ou, Donghong Yu, Xiang Yong, Xiaoli Wang, Bo Zhu, Qiong Zhang, Lei Zhou, Zhaogen Cai, Zenong Cheng

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Impact of kinesin Eg5 inhibition by 3,4-dihydropyrimidin-2(1H)-one derivatives on various breast cancer cell features

Bruna C Guido, Luciana M Ramos, Diego O Nolasco, Catharine C Nobrega, Bárbara YG Andrade, Aline Pic-Taylor, Brenno AD Neto, José R Corrêa

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

A new relative tumor sizing method in epi-metaphyseal osteosarcoma

Seung Hyun Kim, Kyoo-Ho Shin, Eun Hae Park, Yong Jin Cho, Byoung-Kyu Park, Jin-Suck Suh, Woo-Ick Yang

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Altered PPP2R2A and Cyclin D1 expression defines a subgroup of aggressive luminal-like breast cancer

Francisco Beca, Miguel Pereira, Jorge F Cameselle-Teijeiro, Diana Martins, Fernando Schmitt

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Epidemiological patterns of asbestos exposure and spatial clusters of incident cases of malignant mesothelioma from the Italian national registry

Marisa Corfiati, Alberto Scarselli, Alessandra Binazzi, Davide Di Marzio, Marina Verardo, Dario Mirabelli, Valerio Gennaro, Carolina Mensi, Gert Schallemberg, Enzo Merler, Corrado Negro, Antonio Romanelli, Elisabetta Chellini, Stefano Silvestri, Mario Cocchioni, Cristiana Pascucci, Fabrizio Stracci, Elisa Romeo, Luana Trafficante, Italo Angelillo, Simona Menegozzo, Marina Musti, Domenica Cavone, Gabriella Cauzillo, Federico Tallarigo, Rosario Tumino, Massimo Melis, Sergio Iavicoli, Alessandro Marinaccio, ReNaM Working Group

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

The end of the decline in cervical cancer mortality in Spain: trends across the period 1981–2012

Marta Cervantes-Amat, Gonzalo López-Abente, Nuria Aragonés, Marina Pollán, Roberto Pastor-Barriuso, Beatriz Pérez-Gómez

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

A longitudinal study of non-medical determinants of adherence to R-CHOP therapy for diffuse large B-cell lymphoma: implication for survival

Cécile Borel, Sébastien Lamy, Gisèle Compaci, Christian Récher, Pauline Jeanneau, Jean Claude Nogaro, Eric Bauvin, Fabien Despas, Cyrille Delpierre, Guy Laurent

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Which is the best method of sterilization for recycled bone autograft in limb salvage surgery: a radiological, biomechanical and histopathological study in rabbit

Nor Faissal Yasin, Vivek Ajit Singh, Marniza Saad, Effat Omar

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Platelets enhance tissue factor protein and metastasis initiating cell markers, and act as chemoattractants increasing the migration of ovarian cancer cells

Renan Orellana, Sumie Kato, Rafaela Erices, María Loreto Bravo, Pamela Gonzalez, Bárbara Oliva, Sofía Cubillos, Andrés Valdivia, Carolina Ibañez, Jorge Brañes, María Isabel Barriga, Erasmo Bravo, Catalina Alonso, Eva Bustamente, Enrique Castellon, Patricia Hidalgo, Cesar Trigo, Olga Panes, Jaime Pereira, Diego Mezzano, Mauricio A Cuello, Gareth I Owen

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Massively parallel sequencing fails to detect minor resistant subclones in tissue samples prior to tyrosine kinase inhibitor therapy

Carina Heydt, Niklas Kumm, Jana Fassunke, Helen Künstlinger, Michaela Angelika Ihle, Andreas Scheel, Hans-Ulrich Schildhaus, Florian Haller, Reinhard Büttner, Margarete Odenthal, Eva Wardelmann, Sabine Merkelbach-Bruse

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Apparent diffusion coefficient measurement by diffusion weighted magnetic resonance imaging is a useful tool in differentiating renal tumors

Jing-Hong Liu, Shi-Feng Tian, Ye Ju, Ye Li, An-Liang Chen, Li-Hua Chen, Ai-Lian Liu

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Overexpression of IL-15 promotes tumor destruction via NK1.1+ cells in a spontaneous breast cancer model

Amy E Gillgrass, Marianne V Chew, Tamara Krneta, Ali A Ashkar

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Body mass index and participation in organized mammographic screening: a prospective cohort study

Sophie Sell Hellmann, Sisse Helle Njor, Elsebeth Lynge, My von Euler-Chelpin, Anja Olsen, Anne Tjønneland, Ilse Vejborg, Zorana Jovanovic Andersen

01.12.2015 | Study protocol | Ausgabe 1/2015 Open Access

Protocol of a multi-centre randomised controlled trial of a web-based information intervention with nurse-delivered telephone support for haematological cancer patients and their support persons

Jamie Bryant, Rob Sanson-Fisher, William Stevenson, Rochelle Smits, Frans Henskens, Andrew Wei, Flora Tzelepis, Catherine D’Este, Christine Paul, Mariko Carey

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Targeting connexin 43 with α–connexin carboxyl-terminal (ACT1) peptide enhances the activity of the targeted inhibitors, tamoxifen and lapatinib, in breast cancer: clinical implication for ACT1

Christina L Grek, Joshua Matthew Rhett, Jaclynn S Bruce, Melissa A Abt, Gautam S Ghatnekar, Elizabeth S Yeh

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Circulating miR-200c and miR-141 and outcomes in patients with breast cancer

Silvia Antolín, Lourdes Calvo, Moisés Blanco-Calvo, María Paz Santiago, María José Lorenzo-Patiño, Mar Haz-Conde, Isabel Santamarina, Angélica Figueroa, Luis Miguel Antón-Aparicio, Manuel Valladares-Ayerbes

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Epidemiology, clinical profile and treatment patterns of venous thromboembolism in cancer patients in Taiwan: a population-based study

Tan-Wei Chew, Churn-Shiouh Gau, Yu-Wen Wen, Li-Jiuan Shen, C Daniel Mullins, Fei-Yuan Hsiao

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

A pilot study of bevacizumab combined with etoposide and cisplatin in breast cancer patients with leptomeningeal carcinomatosis

Pei-Fang Wu, Ching-Hung Lin, Ching-Hua Kuo, Wei-Wu Chen, Dah-Cherng Yeh, Hsiao-Wei Liao, Shu-Min Huang, Ann-Lii Cheng, Yen-Shen Lu

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

SNAI2/SLUG and estrogen receptor mRNA expression are inversely correlated and prognostic of patient outcome in metastatic non-small cell lung cancer

Akin Atmaca, Ralph W Wirtz, Dominique Werner, Kristina Steinmetz, Silke Claas, Wolfgang M Brueckl, Elke Jäger, Salah-Eddin Al-Batran

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Cancerous inhibitor of protein phosphatase 2A (CIP2A) is an independent prognostic marker in wild-type KRAS metastatic colorectal cancer after colorectal liver metastasectomy

Kuen-Feng Chen, Chueh-Chuan Yen, Jen-Kou Lin, Wei-Shone Chen, Shung-Haur Yang, Jeng-Kai Jiang, Yuan-Tzu Lan, Chun-Chi Lin, Hui-Chuan Yu, Hui-Mei Hsu, Wen-Ling Lin, Hao-Wei Teng

01.12.2015 | Study protocol | Ausgabe 1/2015 Open Access

Screening and treatment of psychological distress in patients with metastatic colorectal cancer: study protocol of the TES trial

Claudia SEW Schuurhuizen, Annemarie MJ Braamse, Aartjan TF Beekman, Hanna Bomhof-Roordink, Judith E Bosmans, Pim Cuijpers, Adriaan W Hoogendoorn, Inge RHM Konings, Mecheline HM van der Linden, Elisabeth CW Neefjes, Henk MW Verheul, Joost Dekker

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Everolimus in metastatic renal cell carcinoma after failure of initial anti–VEGF therapy: final results of a noninterventional study

Lothar Bergmann, Ulrich Kube, Christian Doehn, Thomas Steiner, Peter J Goebell, Manfred Kindler, Edwin Herrmann, Jan Janssen, Steffen Weikert, Michael T Scheffler, Joerg Schmitz, Michael Albrecht, Michael Staehler

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

The impact of FGFR1 and FRS2α expression on sorafenib treatment in metastatic renal cell carcinoma

Thai H Ho, Xian-De Liu, Yanqing Huang, Carla L Warneke, Marcella M Johnson, Anh Hoang, Pheroze Tamboli, Fen Wang, Eric Jonasch

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Is maximum primary tumor diameter still a prognostic factor in patients with nasopharyngeal carcinoma treated using intensity-modulated radiotherapy?

Yong Chen, Xue-Feng Hu, Yan Wang, Hai-Yang Chen, Lin Yang, Li-Zhi Liu, Chun-Yan Cui, Dong-Sheng Liu, Shao-Bo Liang

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

STAT3 is involved in miR-124-mediated suppressive effects on esophageal cancer cells

Yan Cheng, Yang Li, Yuanyuan Nian, Dong Liu, Fei Dai, Jun Zhang

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Mammographic microcalcifications and breast cancer tumorigenesis: a radiologic-pathologic analysis

Madiha Naseem, Joshua Murray, John F Hilton, Jason Karamchandani, Derek Muradali, Hala Faragalla, Chanele Polenz, Dolly Han, David C Bell, Christine Brezden-Masley

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Diagnostic intervals before and after implementation of cancer patient pathways – a GP survey and registry based comparison of three cohorts of cancer patients

Henry Jensen, Marie Louise Tørring, Frede Olesen, Jens Overgaard, Morten Fenger-Grøn, Peter Vedsted

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

A microRNA profile associated with Opisthorchis viverrini-induced cholangiocarcinoma in tissue and plasma

Jordan Plieskatt, Gabriel Rinaldi, Yanjun Feng, Jin Peng, Samantha Easley, Xinying Jia, Jeremy Potriquet, Chawalit Pairojkul, Vajarabhongsa Bhudhisawasdi, Banchob Sripa, Paul J Brindley, Jeffrey Bethony, Jason Mulvenna

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Adult metanephric adenoma presumed to be all benign? A clinical perspective

Gang Li, Yuhong Tang, Renya Zhang, Hualin Song, Shumin Zhang, Yuanjie Niu

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Frequency and distribution of Notch mutations in tumor cell lines

Anders Peter Mutvei, Erik Fredlund, Urban Lendahl

01.12.2015 | Study protocol | Ausgabe 1/2015 Open Access

A phase II RCT and economic analysis of three exercise delivery methods in men with prostate cancer on androgen deprivation therapy

Shabbir MH Alibhai, Daniel Santa Mina, Paul Ritvo, Catherine Sabiston, Murray Krahn, George Tomlinson, Andrew Matthew, Roanne Segal, Padraig Warde, Sara Durbano, Meagan O’Neill, Nicole Culos-Reed

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

A model-based assessment of the cost–utility of strategies to identify Lynch syndrome in early-onset colorectal cancer patients

Tristan Snowsill, Nicola Huxley, Martin Hoyle, Tracey Jones-Hughes, Helen Coelho, Chris Cooper, Ian Frayling, Chris Hyde

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Association between epidermal growth factor gene +61A/G polymorphism and the risk of hepatocellular carcinoma: a meta-analysis based on 16 studies

Guoping Jiang, Ke Yu, Lifang Shao, Xiaobo Yu, Chen Hu, Pei Qian, Haiyang Xie, Jinjun Li, Jie Zheng, Shusen Zheng

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Organized breast screening improves reattendance compared to physician referral: a case control study

Ilia Makedonov, Sumei Gu, Lawrence F Paszat, on behalf of the investigators of the Ontario Cancer Screening Research Network

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Local pelvic irradiation modulates Pharmacokinetics of 5-Fluorouracil in the plasma but not in the Lymphatic System

Chen-Hsi Hsieh, Mei-Ling Hou, Li-Ying Wang, Hung-Chi Tai, Tung-Hu Tsai, Yu-Jen Chen

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Therapeutic effect of intravesical administration of paclitaxel solubilized with poly(2-methacryloyloxyethyl phosphorylcholine-co-n-butyl methacrylate) in an orthotopic bladder cancer model

Koetsu Tamura, Eiji Kikuchi, Tomohiro Konno, Kazuhiko Ishihara, Kazuhiro Matsumoto, Akira Miyajima, Mototsugu Oya

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Management and prognosis of patients with brain metastasis from gestational trophoblastic neoplasia: a 24-year experience in Peking union medical college hospital

Changji Xiao, Junjun Yang, Jing Zhao, Tong Ren, Fengzhi Feng, Xirun Wan, Yang Xiang

01.12.2015 | Research Article | Ausgabe 1/2015 Open Access

Identification of sample-specific regulations using integrative network level analysis

Chengyu Liu, Riku Louhimo, Marko Laakso, Rainer Lehtonen, Sampsa Hautaniemi

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Targeted next generation sequencing of RB1 gene for the molecular diagnosis of Retinoblastoma

Bharanidharan Devarajan, Logambiga Prakash, Thirumalai Raj Kannan, Aloysius A Abraham, Usha Kim, Veerappan Muthukkaruppan, Ayyasamy Vanniarajan

01.12.2015 | Study protocol | Ausgabe 1/2015 Open Access

Internet-based cognitive behavioral therapy for sexual dysfunctions in women treated for breast cancer: design of a multicenter, randomized controlled trial

Susanna B Hummel, Jacques JDM van Lankveld, Hester SA Oldenburg, Daniela EE Hahn, Eva Broomans, Neil K Aaronson

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Neoadjuvant chemoradiation therapy for resectable esophago-gastric adenocarcinoma: a meta-analysis of randomized clinical trials

Tao Fu, Zhao-De Bu, Zi-Yu Li, Lian-Hai Zhang, Xiao-Jiang Wu, Ai-Wen Wu, Fei Shan, Xin Ji, Qiu-Shi Dong, Jia-Fu Ji

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Correlation of Aurora-A expression with the effect of chemoradiation therapy on esophageal squamous cell carcinoma

Kiyokazu Tamotsu, Hiroshi Okumura, Yasuto Uchikado, Yoshiaki Kita, Ken Sasaki, Itaru Omoto, Tetsuhiro Owaki, Takaaki Arigami, Yoshikazu Uenosono, Akihiro Nakajo, Yuko Kijima, Sumiya Ishigami, Shoji Natsugoe

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Down-regulation of NF kappa B activation is an effective therapeutic modality in acquired platinum-resistant bladder cancer

Yujiro Ito, Eiji Kikuchi, Nobuyuki Tanaka, Takeo Kosaka, Eriko Suzuki, Ryuichi Mizuno, Toshiaki Shinojima, Akira Miyajima, Kazuo Umezawa, Mototsugu Oya

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

DNA Polymerases as targets for gene therapy of hepatocellular carcinoma

Hao Liu, Qun Wei, Jia Wang, Xiaoming Huang, Chunchun Li, Qiaoli Zheng, Jiang Cao, Zhenyu Jia

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

PKCα promotes the mesenchymal to amoeboid transition and increases cancer cell invasiveness

Katarína Vaškovičová, Emilia Szabadosová, Vladimír Čermák, Aneta Gandalovičová, Lenka Kasalová, Daniel Rösel, Jan Brábek

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Capecitabine and irinotecan with bevacizumab 2-weekly for metastatic colorectal cancer: the phase II AVAXIRI study

Pilar Garcia-Alfonso, Manuel Chaves, Andrés Muñoz, Antonieta Salud, Maria García-Gonzalez, Cristina Grávalos, Bartomeu Massuti, Encarna González-Flores, Bernardo Queralt, Amelia López-Ladrón, Ferran Losa, Maria Jose Gómez, Amparo Oltra, Enrique Aranda, on behalf of the Spanish Cooperative Group for the Treatment of Digestive Tumors (TTD)

01.12.2015 | Study protocol | Ausgabe 1/2015 Open Access

Finding My Way: protocol of a randomised controlled trial evaluating an internet self-help program for cancer-related distress

Lisa Beatty, Emma Kemp, Tracey Wade, Bogda Koczwara, on behalf of the Finding My Way study investigators

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Circulating miRNAs miR-34a and miR-150 associated with colorectal cancer progression

Sinéad T Aherne, Stephen F Madden, David J Hughes, Barbara Pardini, Alessio Naccarati, Miroslav Levy, Pavel Vodicka, Paul Neary, Paul Dowling, Martin Clynes

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Retrospective evaluation of the incidental finding of 403 papillary thyroid microcarcinomas in 2466 patients undergoing thyroid surgery for presumed benign thyroid disease

Nikola Slijepcevic, Vladan Zivaljevic, Jelena Marinkovic, Sandra Sipetic, Aleksandar Diklic, Ivan Paunovic

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Effects of JWA, XRCC1 and BRCA1 mRNA expression on molecular staging for personalized therapy in patients with advanced esophageal squamous cell carcinoma

Bin Wei, Qin Han, Lijuan Xu, Xiaohui Zhang, Jing Zhu, Li Wan, Yan Jin, Zhaoye Qian, Jingjing Wu, Yong Gao, Jianwei Zhou, Xiaofei Chen

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

High expression of Talin-1 is associated with poor prognosis in patients with nasopharyngeal carcinoma

Ya-Fei Xu, Xian-Yue Ren, Ying-Qin Li, Qing-Mei He, Xin-Ran Tang, Ying Sun, Jian-Yong Shao, Wei-Hua Jia, Tie-Bang Kang, Mu-Sheng Zeng, Na Liu, Jun Ma

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

FGF9 from cancer-associated fibroblasts is a possible mediator of invasion and anti-apoptosis of gastric cancer cells

Chao Sun, Hirokazu Fukui, Ken Hara, Xinxing Zhang, Yoshitaka Kitayama, Hirotsugu Eda, Toshihiko Tomita, Tadayuki Oshima, Shojiro Kikuchi, Jiro Watari, Mitsuru Sasako, Hiroto Miwa

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Systematic review of model-based cervical screening evaluations

Diana Mendes, Iren Bains, Tazio Vanni, Mark Jit

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Transient elevation of glycolysis confers radio-resistance by facilitating DNA repair in cells

Anant Narayan Bhatt, Ankit Chauhan, Suchit Khanna, Yogesh Rai, Saurabh Singh, Ravi Soni, Namita Kalra, Bilikere S Dwarakanath

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Determinants of gastric cancer screening attendance in Korea: a multi-level analysis

Yunryong Chang, Belong Cho, Ki Young Son, Dong Wook Shin, Hosung Shin, Hyung-Kook Yang, Aesun Shin, Keun-Young Yoo

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Transcriptional implications of intragenic DNA methylation in the oestrogen receptor alpha gene in breast cancer cells and tissues

Natalie S Shenker, Kirsty J Flower, Charlotte S Wilhelm-Benartzi, Wei Dai, Emma Bell, Edmund Gore, Mona El Bahrawy, Gillian Weaver, Robert Brown, James M Flanagan

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Nomogram for overall survival of Japanese patients with bone-metastatic prostate cancer

Yasuhide Miyoshi, Kazumi Noguchi, Masahiro Yanagisawa, Masataka Taguri, Satoshi Morita, Ichiro Ikeda, Kiyoshi Fujinami, Takeshi Miura, Kazuki Kobayashi, Hiroji Uemura

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Phase II study of axitinib with doublet chemotherapy in patients with advanced squamous non–small-cell lung cancer

Igor M Bondarenko, Antonella Ingrosso, Paul Bycott, Sinil Kim, Cristina L Cebotaru

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Colorectal carcinomas with KRAS codon 12 mutation are associated with more advanced tumor stages

Wenbin Li, Tian Qiu, Wenxue Zhi, Susheng Shi, Shuangmei Zou, Yun Ling, Ling Shan, Jianming Ying, Ning Lu

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Early diagnostic value of Bcl-3 localization in colorectal cancer

Karunakar Saamarthy, Sofie Björner, Martin Johansson, Göran Landberg, Ramin Massoumi, Karin Jirström, Katarzyna Chmielarska Masoumi

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Wilms’ tumor gene 1 regulates p63 and promotes cell proliferation in squamous cell carcinoma of the head and neck

Xingru Li, Sofia Ottosson, Sihan Wang, Emma Jernberg, Linda Boldrup, Xiaolian Gu, Karin Nylander, Aihong Li

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

MTA2 enhances colony formation and tumor growth of gastric cancer cells through IL-11

Chenfei Zhou, Jun Ji, Qu Cai, Min Shi, Xuehua Chen, Yingyan Yu, Zhenggang Zhu, Jun Zhang

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Risk factors and clinical outcomes of acute myeloid leukaemia with central nervous system involvement in adults

Chieh-Lung Cheng, Chi-Cheng Li, Hsin-An Hou, Wei-Quan Fang, Chin-Hao Chang, Chien-Ting Lin, Jih-Luh Tang, Wen-Chien Chou, Chien-Yuan Chen, Ming Yao, Shang-Yi Huang, Bor-Sheng Ko, Shang-Ju Wu, Woei Tsay, Hwei-Fang Tien

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

MicroRNA-10a is reduced in breast cancer and regulated in part through retinoic acid

Sonja Khan, Deirdre Wall, Catherine Curran, John Newell, Michael J Kerin, Roisin M Dwyer

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Nonsense and missense mutation of mitochondrial ND6 gene promotes cell migration and invasion in human lung adenocarcinoma

Yang Yuan, Weixing Wang, Huizhong Li, Yongwei Yu, Jin Tao, Shengdong Huang, Zhiyong Zeng

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

The pretreatment albumin to globulin ratio predicts chemotherapeutic outcomes in patients with unresectable metastatic colorectal cancer

Masatsune Shibutani, Kiyoshi Maeda, Hisashi Nagahara, Hiroshi Ohtani, Yasuhito Iseki, Tetsuro Ikeya, Kenji Sugano, Kosei Hirakawa

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

The emerging outcome of postoperative radiotherapy for stage IIIA(N2) non-small cell lung cancer patients: based on the three-dimensional conformal radiotherapy technique and institutional standard clinical target volume

Wen Feng, Qin Zhang, Xiao-Long Fu, Xu-Wei Cai, Zheng-Fei Zhu, Huan-Jun Yang, Jia-Qing Xiang, Ya-Wei Zhang, Hai-Quan Chen

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Clusterin transcript variants expression in thyroid tumor: a potential marker of malignancy?

Paolo Fuzio, Anna Napoli, Anna Ciampolillo, Serafina Lattarulo, Angela Pezzolla, Nicoletta Nuzziello, Sabino Liuni, Francesco Giorgino, Eugenio Maiorano, Elda Perlino

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

A novel inflammation-based prognostic score in esophageal squamous cell carcinoma: the C-reactive protein/albumin ratio

Xiao-li Wei, Feng-hua Wang, Dong-sheng Zhang, Miao-zhen Qiu, Chao Ren, Ying Jin, Yi-xin Zhou, De-shen Wang, Ming-ming He, Long Bai, Feng Wang, Hui-yan Luo, Yu-hong Li, Rui-hua Xu

01.12.2015 | Technical advance | Ausgabe 1/2015 Open Access

Cytotoxicity and infiltration of human NK cells in in vivo-like tumor spheroids

Ariane Giannattasio, Sandra Weil, Stephan Kloess, Nariman Ansari, Ernst H K Stelzer, Adelheid Cerwenka, Alexander Steinle, Ulrike Koehl, Joachim Koch

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Proteoglycan-based diversification of disease outcome in head and neck cancer patients identifies NG2/CSPG4 and syndecan-2 as unique relapse and overall survival predicting factors

Anna Farnedi, Silvia Rossi, Nicoletta Bertani, Mariolina Gulli, Enrico Maria Silini, Maria Teresa Mucignat, Tito Poli, Enrico Sesenna, Davide Lanfranco, Lucio Montebugnoli, Elisa Leonardi, Claudio Marchetti, Renato Cocchi, Andrea Ambrosini-Spaltro, Maria Pia Foschini, Roberto Perris

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Randomized phase III trial of radiotherapy or chemoradiotherapy with topotecan and cisplatin in intermediate-risk cervical cancer patients after radical hysterectomy

Wenze Sun, Tao Wang, Fan Shi, Jiquan Wang, Juan Wang, Beina Hui, Yingbing Zhang, Jinli Lu, Hongwei Chen, Zi Liu

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Healthcare costs attributable to the treatment of patients with spinal metastases: a cohort study with up to 8 years follow-up

Line Stjernholm Tipsmark, Cody Eric Bünger, Miao Wang, Søren Schmidt Morgen, Benny Dahl, Rikke Søgaard

01.12.2015 | Study protocol | Ausgabe 1/2015 Open Access

Efficacy of laparoscopic subtotal gastrectomy with D2 lymphadenectomy for locally advanced gastric cancer: the protocol of the KLASS-02 multicenter randomized controlled clinical trial

Hoon Hur, Hyun Yong Lee, Hyuk-Joon Lee, Min Chan Kim, Woo Jin Hyung, Young Kyu Park, Wook Kim, Sang-Uk Han

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Inhibition of colony stimulating factor-1 receptor improves antitumor efficacy of BRAF inhibition

Stephen Mok, Jennifer Tsoi, Richard C Koya, Siwen Hu-Lieskovan, Brian L West, Gideon Bollag, Thomas G Graeber, Antoni Ribas

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

ZFP36 stabilizes RIP1 via degradation of XIAP and cIAP2 thereby promoting ripoptosome assembly

Tommaso Selmi, Claudia Alecci, Miriam dell’ Aquila, Lucia Montorsi, Andrea Martello, Filippo Guizzetti, Nicola Volpi, Sandra Parenti, Sergio Ferrari, Paolo Salomoni, Alexis Grande, Tommaso Zanocco-Marani

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Mechanism study of peptide GMBP1 and its receptor GRP78 in modulating gastric cancer MDR by iTRAQ-based proteomic analysis

Xiaojuan Wang, Yani Li, Guanghui Xu, Muhan Liu, Lin Xue, Lijuan Liu, Sijun Hu, Ying Zhang, Yongzhan Nie, Shuhui Liang, Biaoluo Wang, Jie Ding

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Metronomic oral vinorelbine as first-line treatment in elderly patients with advanced non-small cell lung cancer: results of a phase II trial (MOVE trial)

Andrea Camerini, Cheti Puccetti, Sara Donati, Chiara Valsuani, Maria Cristina Petrella, Gianna Tartarelli, Paolo Puccinelli, Domenico Amoroso

01.12.2015 | Technical advance | Ausgabe 1/2015 Open Access

High-recovery visual identification and single-cell retrieval of circulating tumor cells for genomic analysis using a dual-technology platform integrated with automated immunofluorescence staining

Daniel E Campton, Arturo B Ramirez, Joshua J Nordberg, Nick Drovetto, Alisa C Clein, Paulina Varshavskaya, Barry H Friemel, Steve Quarre, Amy Breman, Michael Dorschner, Sibel Blau, C Anthony Blau, Daniel E Sabath, Jackie L Stilwell, Eric P Kaldjian

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Chromosomal instability as a prognostic marker in cervical cancer

Christine How, Jeff Bruce, Jonathan So, Melania Pintilie, Benjamin Haibe-Kains, Angela Hui, Blaise A Clarke, David W Hedley, Richard P Hill, Michael Milosevic, Anthony Fyles, Fei-Fei Liu

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

HBx induced AFP receptor expressed to activate PI3K/AKT signal to promote expression of Src in liver cells and hepatoma cells

Mingyue Zhu, Junli Guo, Wei Li, Hua Xia, Yan Lu, Xu Dong, Yi Chen, Xieju Xie, Shigan Fu, Mengsen Li

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Prognostic model for long-term survival of locally advanced non-small-cell lung cancer patients after neoadjuvant radiochemotherapy and resection integrating clinical and histopathologic factors

Christoph Pöttgen, Martin Stuschke, Britta Graupner, Dirk Theegarten, Thomas Gauler, Verena Jendrossek, Lutz Freitag, Jehad Abu Jawad, Eleni Gkika, Jeremias Wohlschlaeger, Stefan Welter, Matthias Hoiczyk, Martin Schuler, Georgios Stamatis, Wilfried Eberhardt

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Utility of SAM68 in the progression and prognosis for bladder cancer

Zhiling Zhang, Chunping Yu, Yonghong Li, Lijuan Jiang, Fangjian Zhou

01.12.2015 | Study protocol | Ausgabe 1/2015 Open Access

Treatment strategies in colorectal cancer patients with initially unresectable liver-only metastases, a study protocol of the randomised phase 3 CAIRO5 study of the Dutch Colorectal Cancer Group (DCCG)

Joost Huiskens, Thomas M van Gulik, Krijn P van Lienden, Marc RW Engelbrecht, Gerrit A Meijer, Nicole CT van Grieken, Jonne Schriek, Astrid Keijser, Linda Mol, I Quintus Molenaar, Cornelis Verhoef, Koert P de Jong, Kees HC Dejong, Geert Kazemier, Theo M Ruers, Johanus HW de Wilt, Harm van Tinteren, Cornelis JA Punt

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

The prevention, detection and management of cancer treatment-induced cardiotoxicity: a meta-review

Aaron Conway, Alexandra L McCarthy, Petra Lawrence, Robyn A Clark

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Plasma membrane proteomic analysis of human Gastric Cancer tissues: revealing flotillin 1 as a marker for Gastric Cancer

Wen Gao, Jing Xu, Fuqiang Wang, Long Zhang, Rui Peng, Yongqian Shu, Jindao Wu, Qiyun Tang, Yunxia Zhu

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

URG4/URGCP enhances the angiogenic capacity of human hepatocellular carcinoma cells in vitro via activation of the NF-κB signaling pathway

Sizhong Xing, Bing Zhang, Ruixi Hua, William Chi-shing Tai, Zhirong Zeng, Binhui Xie, Chenghui Huang, Jisu Xue, Shiqiu Xiong, Jianyong Yang, Side Liu, Heping Li

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Transcriptional changes associated with resistance to inhibitors of epidermal growth factor receptor revealed using metaanalysis

Sidra Younis, Qamar Javed, Miroslav Blumenberg

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

The prognostic significance of lymphovascular invasion in patients with resectable gastric cancer: a large retrospective study from Southern China

Peng Li, Hao-Qiang He, Chong-Mei Zhu, Yi-Hong Ling, Wan-Ming Hu, Xin-Ke Zhang, Rong-Zhen Luo, Jing-Ping Yun, Dan Xie, Yuan-Fang Li, Mu-Yan Cai

01.12.2015 | Case report | Ausgabe 1/2015 Open Access

Pain, PSA flare, and bone scan response in a patient with metastatic castration-resistant prostate cancer treated with radium-223, a case report

Megan A McNamara, Daniel J George

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Soluble EpCAM levels in ascites correlate with positive cytology and neutralize catumaxomab activity in vitro

Andreas Seeber, Agnieszka Martowicz, Gilbert Spizzo, Thomas Buratti, Peter Obrist, Dominic Fong, Guenther Gastl, Gerold Untergasser

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Reducing tumor growth and angiogenesis using a triple therapy measured with Contrast-enhanced ultrasound (CEUS)

Philipp Marius Paprottka, Svenja Roßpunt, Michael Ingrisch, Clemens C Cyran, Konstantin Nikolaou, Maximilian F Reiser, Brigitte Mack, Olivier Gires, Dirk A Clevert, Pamela Zengel

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

The combination of sorafenib and everolimus shows antitumor activity in preclinical models of malignant pleural mesothelioma

Ymera Pignochino, Carmine Dell’Aglio, Simona Inghilleri, Michele Zorzetto, Marco Basiricò, Federica Capozzi, Marta Canta, Davide Piloni, Francesca Cemmi, Dario Sangiolo, Loretta Gammaitoni, Marco Soster, Serena Marchiò, Ernesto Pozzi, Patrizia Morbini, Maurizio Luisetti, Massimo Aglietta, Giovanni Grignani, Giulia M Stella

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Transcriptional profiling provides insights into metronomic cyclophosphamide-activated, innate immune-dependent regression of brain tumor xenografts

Joshua C Doloff, David J Waxman

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Mesothelioma patient derived tumor xenografts with defined BAP1 mutations that mimic the molecular characteristics of human malignant mesothelioma

Neetu Kalra, Jingli Zhang, Anish Thomas, Liqiang Xi, Mitchell Cheung, Jacqueline Talarchek, Sandra Burkett, Maria G Tsokos, Yuanbin Chen, Mark Raffeld, Markku Miettinen, Ira Pastan, Joseph R Testa, Raffit Hassan

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

The prognostic value of EGFR overexpression and amplification in Esophageal squamous cell Carcinoma

Dongxian Jiang, Xiaojing Li, Haixing Wang, Yuan Shi, Chen Xu, Shaohua Lu, Jie Huang, Yifan Xu, Haiying Zeng, Jieakesu Su, Yingyong Hou, Lijie Tan

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Feasibility of a multimodal 18F-FDG-directed lymph node surgical excisional biopsy approach for appropriate diagnostic tissue sampling in patients with suspected lymphoma

Stephen P Povoski, Nathan C Hall, Douglas A Murrey Jr, Chadwick L Wright, Edward W Martin Jr

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Prognostic value of tumor suppressors in osteosarcoma before and after neoadjuvant chemotherapy

Bernhard Robl, Chantal Pauli, Sander Martijn Botter, Beata Bode-Lesniewska, Bruno Fuchs

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

High expression of KPNA2 defines poor prognosis in patients with upper tract urothelial carcinoma treated with radical nephroureterectomy

Bentao Shi, Boxing Su, Dong Fang, Yuan Tang, Gengyan Xiong, Zhongqiang Guo, Qun He, Xinyu Yang, Wei Zhao, Yinglu Guo, Xuesong Li, Liqun Zhou

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Significance of KRAS/PAK1/Crk pathway in non-small cell lung cancer oncogenesis

Fariborz Mortazavi, Jie Lu, Ryan Phan, Michael Lewis, Kenny Trinidad, Amir Aljilani, Gholamhossein Pezeshkpour, Fuyuhiko Tamanoi

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Improved false negative rate of axillary status using sentinel lymph node biopsy and ultrasound-suspicious lymph node sampling in patients with early breast cancer

Yulong Wang, Haiyan Dong, Hongyan Wu, Li Zhang, Kai Yuan, Hongqiang Chen, Mingwen Jiao, Rongzhan Fu

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Genome-wide association study of susceptibility loci for breast cancer in Sardinian population

Grazia Palomba, Angela Loi, Eleonora Porcu, Antonio Cossu, Ilenia Zara, Mario Budroni, Mariano Dei, Sandra Lai, Antonella Mulas, Nina Olmeo, Maria Teresa Ionta, Francesco Atzori, Gianmauro Cuccuru, Maristella Pitzalis, Magdalena Zoledziewska, Nazario Olla, Mario Lovicu, Marina Pisano, Gonçalo R. Abecasis, Manuela Uda, Francesco Tanda, Kyriaki Michailidou, Douglas F. Easton, Stephen J. Chanock, Robert N. Hoover, David J. Hunter, David Schlessinger, Serena Sanna, Laura Crisponi, Giuseppe Palmieri

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Randomized phase III clinical trial comparing the combination of capecitabine and oxaliplatin (CAPOX) with the combination of 5-fluorouracil, leucovorin and oxaliplatin (modified FOLFOX6) as adjuvant therapy in patients with operated high-risk stage II or stage III colorectal cancer

Dimitrios Pectasides, Vasilios Karavasilis, George Papaxoinis, Georgia Gourgioti, Thomas Makatsoris, Georgia Raptou, Eleni Vrettou, Joseph Sgouros, Epaminontas Samantas, George Basdanis, Pavlos Papakostas, Dimitrios Bafaloukos, Vassiliki Kotoula, Haralambos P. Kalofonos, Chrisoula D. Scopa, George Pentheroudakis, George Fountzilas

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Dysregulated cholinergic network as a novel biomarker of poor prognostic in patients with head and neck squamous cell carcinoma

Ana Cristina Castillo-González, Susana Nieto-Cerón, Juan Pablo Pelegrín-Hernández, María Fernanda Montenegro, José Antonio Noguera, María Fuensanta López-Moreno, José Neptuno Rodríguez-López, Cecilio J Vidal, Diego Hellín-Meseguer, Juan Cabezas-Herrera

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

The relationship between glasgow prognostic score and serum tumor markers in patients with advanced non-small cell lung cancer

Ai-Gui Jiang, Hong-Lin Chen, Hui-Yu Lu

01.12.2015 | Technical advance | Ausgabe 1/2015 Open Access

Optimisation of immunofluorescence methods to determine MCT1 and MCT4 expression in circulating tumour cells

Stephen Kershaw, Jeffrey Cummings, Karen Morris, Jonathan Tugwood, Caroline Dive

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Hospital discharges for fever and neutropenia in pediatric cancer patients: United States, 2009

Emily L. Mueller, Kelly J. Walkovich, Rajen Mody, Achamyeleh Gebremariam, Matthew M. Davis

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

The role of c-Src in the invasion and metastasis of hepatocellular carcinoma cells induced by association of cell surface GRP78 with activated α2M

Song Zhao, Hongdan Li, Qingjun Wang, Chang Su, Guan Wang, Huijuan Song, Liang Zhao, Zhidong Luan, Rongjian Su

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Mitogen- and stress-activated Kinase 1 mediates Epstein-Barr virus latent membrane protein 1-promoted cell transformation in nasopharyngeal carcinoma through its induction of Fra-1 and c-Jun genes

Binbin Li, Zheng Wan, Guoliang Huang, Zunnan Huang, Xiangning Zhang, Dan Liao, Shengqun Luo, Zhiwei He

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

NBPF1, a tumor suppressor candidate in neuroblastoma, exerts growth inhibitory effects by inducing a G1 cell cycle arrest

Vanessa Andries, Karl Vandepoele, Katrien Staes, Geert Berx, Pieter Bogaert, Gert Van Isterdael, Daisy Ginneberge, Eef Parthoens, Jonathan Vandenbussche, Kris Gevaert, Frans van Roy

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Impact of neo-adjuvant Sorafenib treatment on liver transplantation in HCC patients - a prospective, randomized, double-blind, phase III trial

Katrin Hoffmann, Tom Ganten, Daniel Gotthardtp, Boris Radeleff, Utz Settmacher, Otto Kollmar, Silvio Nadalin, Irini Karapanagiotou-Schenkel, Christof von Kalle, Dirk Jäger, Markus W Büchler, Peter Schemmer

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Increased risk of second primary malignancies following uterine cancer: a population-based study in Taiwan over a 30-year period

Kuan-Der Lee, Chao-Yu Chen, Huei-Jean Huang, Ting-Yao Wang, David Teng, Shih-Hao Huang, Chyong-Huey Lai, Min-Chi Chen

01.12.2015 | Study protocol | Ausgabe 1/2015 Open Access

The patient-breast cancer care pathway: how could it be optimized?

Sandrine Baffert, Huong Ly Hoang, Anne Brédart, Bernard Asselain, Séverine Alran, Hélène Berseneff, Cyrille Huchon, Caroline Trichot, Aline Combes, Karine Alves, Martin Koskas, Thuy Nguyen, Aurélie Roulot, Roman Rouzier, Delphine Héquet

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Phase I/II study of temsirolimus for patients with unresectable Hepatocellular Carcinoma (HCC)- a correlative study to explore potential biomarkers for response

Winnie Yeo, Stephen L Chan, Frankie KF Mo, Cheuk M Chu, Joyce WY Hui, Joanne HM Tong, Anthony WH Chan, Jane Koh, Edwin P Hui, Herbert Loong, Kirsty Lee, Leung Li, Brigette Ma, Ka F To, Simon CH Yu

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Preoperative serum CA125: a useful marker for surgical management of endometrial cancer

Tao Jiang, Ling Huang, Shulan Zhang

01.12.2015 | Case report | Ausgabe 1/2015 Open Access

A male patient with acromegaly and breast cancer: treating acromegaly to control tumor progression

Paola Leporati, Rodolfo Fonte, Luca de Martinis, Alberto Zambelli, Flavia Magri, Lorenzo Pavesi, Mario Rotondi, Luca Chiovato

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Hyperemesis gravidarum and risk of cancer in offspring, a Scandinavian registry-based nested case–control study

Kathrine F. Vandraas, Åse V. Vikanes, Nathalie C. Støer, Rebecca Troisi, Olof Stephansson, Henrik T. Sørensen, Siri Vangen, Per Magnus, Andrej M. Grjibovski, Tom Grotmol

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Variable expression levels of keratin and vimentin reveal differential EMT status of circulating tumor cells and correlation with clinical characteristics and outcome of patients with metastatic breast cancer

Hara Polioudaki, Sofia Agelaki, Rena Chiotaki, Eleni Politaki, Dimitris Mavroudis, Alexios Matikas, Vassilis Georgoulias, Panayiotis A Theodoropoulos

01.12.2015 | Case report | Ausgabe 1/2015 Open Access

Prolonged survival of a patient with metastatic leptomeningeal melanoma treated with BRAF inhibition-based therapy: a case report

Dae Won Kim, Edelyn Barcena, Urvi N Mehta, Michelle L Rohlfs, Ashok J Kumar, Marta Penas-Prado, Kevin B Kim

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Mitochondrially targeted vitamin E succinate efficiently kills breast tumour-initiating cells in a complex II-dependent manner

Bing Yan, Marina Stantic, Renata Zobalova, Ayenachew Bezawork-Geleta, Michael Stapelberg, Jan Stursa, Katerina Prokopova, Lanfeng Dong, Jiri Neuzil

01.12.2015 | Case report | Ausgabe 1/2015 Open Access

Pazopanib for metastatic pulmonary epithelioid hemangioendothelioma—a suitable treatment option: case report and review of anti-angiogenic treatment options

Valeriya Semenisty, Inna Naroditsky, Zohar Keidar, Gil Bar-Sela

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

The impact of HER2 phenotype of circulating tumor cells in metastatic breast cancer: a retrospective study in 107 patients

Markus Wallwiener, Andreas Daniel Hartkopf, Sabine Riethdorf, Juliane Nees, Martin Ronald Sprick, Birgitt Schönfisch, Florin-Andrei Taran, Jörg Heil, Christof Sohn, Klaus Pantel, Andreas Trumpp, Andreas Schneeweiss

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Identification of novel drugs to target dormant micrometastases

Robert E. Hurst, Paul J. Hauser, Youngjae You, Lora C. Bailey-Downs, Anja Bastian, Stephen M. Matthews, Jessica Thorpe, Christine Earle, Lilly Y. W. Bourguignon, Michael A. Ihnat

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Opportunistic mammography screening provides effective detection rates in a limited resource healthcare system

Yew-Ching Teh, Gie-Hooi Tan, Nur Aishah Taib, Kartini Rahmat, Caroline Judy Westerhout, Farhana Fadzli, Mee-Hoong See, Suniza Jamaris, Cheng-Har Yip

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Clinical characteristics of narrow-band imaging of oral erythroplakia and its correlation with pathology

Shih-Wei Yang, Yun-Shien Lee, Liang-Che Chang, Cheng-Cheng Hwang, Cheng-Ming Luo, Tai-An Chen

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Autoantibodies in breast cancer sera are not epiphenomena and may participate in carcinogenesis

Félix Fernández Madrid, Marie-Claire Maroun, Ofelia A Olivero, Michael Long, Azadeh Stark, Lawrence I Grossman, Walter Binder, Jingsheng Dong, Matthew Burke, S David Nathanson, Richard Zarbo, Dhananjay Chitale, Rocío Zeballos-Chávez, Carol Peebles

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Early detection of breast cancer using total biochemical analysis of peripheral blood components: a preliminary study

Udi Zelig, Eyal Barlev, Omri Bar, Itai Gross, Felix Flomen, Shaul Mordechai, Joseph Kapelushnik, Ilana Nathan, Hanoch Kashtan, Nir Wasserberg, Osnat Madhala-Givon

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Fractal analysis of nuclear histology integrates tumor and stromal features into a single prognostic factor of the oral cancer microenvironment

Pinaki Bose, Nigel T Brockton, Kelly Guggisberg, Steven C Nakoneshny, Elizabeth Kornaga, Alexander C Klimowicz, Mauro Tambasco, Joseph C Dort

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Radiographers supporting radiologists in the interpretation of screening mammography: a viable strategy to meet the shortage in the number of radiologists

Gabriela Torres-Mejía, Robert A. Smith, María de la Luz Carranza-Flores, Andy Bogart, Louis Martínez-Matsushita, Diana L. Miglioretti, Karla Kerlikowske, Carolina Ortega-Olvera, Ernesto Montemayor-Varela, Angélica Angeles-Llerenas, Sergio Bautista-Arredondo, Gilberto Sánchez-González, Olga G. Martínez-Montañez, Santos R. Uscanga-Sánchez, Eduardo Lazcano-Ponce, Mauricio Hernández-Ávila

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

The glutamate transport inhibitor DL-Threo-β-Benzyloxyaspartic acid (DL-TBOA) differentially affects SN38- and oxaliplatin-induced death of drug-resistant colorectal cancer cells

Elena Pedraz-Cuesta, Sandra Christensen, Anders A. Jensen, Niels Frank Jensen, Lennart Bunch, Maria Unni Romer, Nils Brünner, Jan Stenvang, Stine Falsig Pedersen

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

The loss in expectation of life after colon cancer: a population-based study

Therese M-L Andersson, Paul W. Dickman, Sandra Eloranta, Annika Sjövall, Mats Lambe, Paul C. Lambert

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Oncology patients overwhelmingly support tissue banking

Jamie Bryant, Rob Sanson-Fisher, Elizabeth Fradgley, Timothy Regan, Breanne Hobden, Stephen P. Ackland

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Impact of cancer and chemotherapy on autonomic nervous system function and cardiovascular reactivity in young adults with cancer: a case-controlled feasibility study

Scott C. Adams, Ronald Schondorf, Julie Benoit, Robert D. Kilgour

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Targeted deep sequencing of mucinous ovarian tumors reveals multiple overlapping RAS-pathway activating mutations in borderline and cancerous neoplasms

Robertson Mackenzie, Stefan Kommoss, Boris J. Winterhoff, Benjamin R. Kipp, Joaquin J. Garcia, Jesse Voss, Kevin Halling, Anthony Karnezis, Janine Senz, Winnie Yang, Elena-Sophie Prigge, Miriam Reuschenbach, Magnus Von Knebel Doeberitz, Blake C. Gilks, David G. Huntsman, Jamie Bakkum-Gamez, Jessica N. McAlpine, Michael S. Anglesio

01.12.2015 | Study protocol | Ausgabe 1/2015 Open Access

Self-management support intervention to control cancer pain in the outpatient setting: a randomized controlled trial study protocol

Laura MJ Hochstenbach, Annemie M Courtens, Sandra MG Zwakhalen, Maarten van Kleef, Luc P de Witte

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

A seven-gene CpG-island methylation panel predicts breast cancer progression

Yan Li, Anatoliy A. Melnikov, Victor Levenson, Emanuela Guerra, Pasquale Simeone, Saverio Alberti, Youping Deng

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Concordance analysis of methylation biomarkers detection in self-collected and physician-collected samples in cervical neoplasm

Cheng-Chang Chang, Rui-Lan Huang, Yu-Ping Liao, Po-Hsuan Su, Yaw-Wen Hsu, Hui-Chen Wang, Chau-Yang Tien, Mu-Hsien Yu, Ya-Wen Lin, Hung-Cheng Lai

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Benefit of adjuvant chemotherapy in patients with T4 UICC II colon cancer

Andreas Teufel, Michael Gerken, Janine Hartl, Timo Itzel, Stefan Fichtner-Feigl, Christian Stroszczynski, Hans Jürgen Schlitt, Ferdinand Hofstädter, Monika Klinkhammer-Schalke

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Risk factors of PSA progression and overall survival in patients with localized and locally advanced prostate cancer treated with primary androgen deprivation therapy

Atsushi Tomioka, Nobumichi Tanaka, Motokiyo Yoshikawa, Makito Miyake, Satoshi Anai, Yoshitomo Chihara, Eijiro Okajima, Akihide Hirayama, Yoshihiko Hirao, Kiyohide Fujimoto

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

The Danish cancer pathway for patients with serious non-specific symptoms and signs of cancer–a cross-sectional study of patient characteristics and cancer probability

Mads Lind Ingeman, Morten Bondo Christensen, Flemming Bro, Søren T. Knudsen, Peter Vedsted

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Enhancement of hypoxia-activated prodrug TH-302 anti-tumor activity by Chk1 inhibition

Fanying Meng, Deepthi Bhupathi, Jessica D Sun, Qian Liu, Dharmendra Ahluwalia, Yan Wang, Mark D Matteucci, Charles P Hart

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Pegylated liposomal doxorubicin (Lipo-Dox®) combined with cyclophosphamide and 5-fluorouracil is effective and safe as salvage chemotherapy in taxane-treated metastatic breast cancer: an open-label, multi-center, non-comparative phase II study

Kun-Ming Rau, Yung-Chang Lin, Yen-Yang Chen, Jen-Shi Chen, Kuan-Der Lee, Cheng-Hsu Wang, Hsien-Kun Chang

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

How do we estimate survival? External validation of a tool for survival estimation in patients with metastatic bone disease—decision analysis and comparison of three international patient populations

Andrea Piccioli, M. Silvia Spinelli, Jonathan A. Forsberg, Rikard Wedin, John H. Healey, Vincenzo Ippolito, Primo Andrea Daolio, Pietro Ruggieri, Giulio Maccauro, Alessandro Gasbarrini, Roberto Biagini, Raimondo Piana, Flavio Fazioli, Alessandro Luzzati, Alberto Di Martino, Francesco Nicolosi, Francesco Camnasio, Michele Attilio Rosa, Domenico Andrea Campanacci, Vincenzo Denaro, Rodolfo Capanna

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Iron-free and iron-saturated bovine lactoferrin inhibit survivin expression and differentially modulate apoptosis in breast cancer

Jessica A. Gibbons, Jagat R. Kanwar, Rupinder K. Kanwar

01.12.2015 | Case report | Ausgabe 1/2015 Open Access

A case of metastatic renal cell carcinoma and bile duct carcinoma treated with a combination of sunitinib and gemcitabine

Kotoe Takayoshi, Kosuke Sagara, Keita Uchino, Hitoshi Kusaba, Naotaka Sakamoto, Atsushi Iguchi, Eishi Baba

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Tumor-induced loss of mural Connexin 43 gap junction activity promotes endothelial proliferation

Mayur Choudhary, Christine Naczki, Wenhong Chen, Keith D. Barlow, L. Douglas Case, Linda J. Metheny-Barlow

01.12.2015 | Study protocol | Ausgabe 1/2015 Open Access

Adjuvant hyperthermic intraperitoneal chemotherapy (HIPEC) in patients with colon cancer at high risk of peritoneal carcinomatosis; the COLOPEC randomized multicentre trial

Charlotte E L Klaver, Gijsbert D Musters, Willem A Bemelman, Cornelis J A Punt, Victor J Verwaal, Marcel GW Dijkgraaf, Arend GJ Aalbers, Jarmila DW van der Bilt, Djamila Boerma, Andre JA Bremers, Jacobus WA Burger, Christianne J Buskens, Pauline Evers, Robert J van Ginkel, Wilhelmina MU van Grevenstein, Patrick HJ Hemmer, Ignace HJT de Hingh, Laureen A Lammers, Barbara L van Leeuwen, Wilhelmus JHJ Meijerink, Simon W Nienhuijs, Jolien Pon, Sandra A Radema, Bert van Ramshorst, Petur Snaebjornsson, Jurriaan B Tuynman, Elisabeth A te Velde, Marinus J Wiezer, Johannes HW de Wilt, Pieter J Tanis

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Leucopenia and treatment efficacy in advanced nasopharyngeal carcinoma

Zhen Su, Yan-Ping Mao, Pu-Yun OuYang, Jie Tang, Xiao-Wen Lan, Fang-Yun Xie

01.12.2015 | Study protocol | Ausgabe 1/2015 Open Access

DECIDER: prospective randomized multicenter phase II trial of low-dose decitabine (DAC) administered alone or in combination with the histone deacetylase inhibitor valproic acid (VPA) and all-trans retinoic acid (ATRA) in patients >60 years with acute myeloid leukemia who are ineligible for induction chemotherapy

Olga Grishina, Claudia Schmoor, Konstanze Döhner, Björn Hackanson, Beate Lubrich, Annette M. May, Caroline Cieslik, Michael J. Müller, Michael Lübbert

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Low expression levels of hepsin and TMPRSS3 are associated with poor breast cancer survival

Mikko Pelkonen, Kaisa Luostari, Maria Tengström, Hermanni Ahonen, Bozena Berdel, Vesa Kataja, Ylermi Soini, Veli-Matti Kosma, Arto Mannermaa

01.12.2015 | Study protocol | Ausgabe 1/2015 Open Access

BCG+MMC trial: adding mitomycin C to BCG as adjuvant intravesical therapy for high-risk, non-muscle-invasive bladder cancer: a randomised phase III trial (ANZUP 1301)

Dickon Hayne, Martin Stockler, Steve P. McCombie, Venu Chalasani, Anne Long, Andrew Martin, Shomik Sengupta, Ian D. Davis

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Polymorphisms and plasma levels of IL-27: impact on genetic susceptibility and clinical outcome of bladder cancer

Bin Zhou, Peng Zhang, Tielong Tang, Hong Liao, Kui Zhang, Yan Pu, Peng Chen, Yaping Song, Lin Zhang

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Effect of genetic ancestry on leukocyte global DNA methylation in cancer patients

Mónica Cappetta, María Berdasco, Jimena Hochmann, Carolina Bonilla, Mónica Sans, Pedro C Hidalgo, Nora Artagaveytia, Rick Kittles, Miguel Martínez, Manel Esteller, Bernardo Bertoni

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Effects of statin use on volumetric mammographic density: results from the KARMA study

Ida Skarping, Judith S. Brand, Per Hall, Signe Borgquist

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Compounds identified by virtual docking to a tetrameric EGFR extracellular domain can modulate Grb2 internalization

Ursula D. Ramirez, Anna S. Nikonova, Hanqing Liu, Anna Pecherskaya, Sarah H. Lawrence, Ilya G. Serebriiskii, Yan Zhou, Matthew K. Robinson, Margret B. Einarson, Erica A. Golemis, Eileen K. Jaffe

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

MicroRNA-217 functions as a prognosis predictor and inhibits colorectal cancer cell proliferation and invasion via an AEG-1 dependent mechanism

Bo Wang, Zhan-long Shen, Ke-wei Jiang, Gang Zhao, Chun-you Wang, Yi-chao Yan, Yang Yang, Ji-zhun Zhang, Chao Shen, Zhi-dong Gao, Ying-jiang Ye, Shan Wang

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Micro actions in colorectal cancer screening participation: a population-based survey study

Siu Hing Lo, Jo Waller, Charlotte Vrinten, Christian von Wagner

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

A GSDMB enhancer-driven HSV thymidine kinase-expressing vector for controlling occult peritoneal dissemination of gastric cancer cells

Norihisa Saeki, Rie Komatsuzaki, Fumiko Chiwaki, Kazuyoshi Yanagihara, Hiroki Sasaki

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

17β-estradiol induces stearoyl-CoA desaturase-1 expression in estrogen receptor-positive breast cancer cells

Anissa Belkaid, Sabrina R. Duguay, Rodney J. Ouellette, Marc E. Surette

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Prognostic impact of CXCL16 and CXCR6 in non-small cell lung cancer: combined high CXCL16 expression in tumor stroma and cancer cells yields improved survival

Sigurd M. Hald, Yury Kiselev, Samer Al-Saad, Elin Richardsen, Charles Johannessen, Marte Eilertsen, Thomas K. Kilvaer, Khalid Al-Shibli, Sigve Andersen, Lill-Tove Busund, Roy M. Bremnes, Tom Donnem

01.12.2015 | Case report | Ausgabe 1/2015 Open Access

Multiple gene aberrations and breast cancer: lessons from super-responders

Jennifer J. Wheler, Johnique T. Atkins, Filip Janku, Stacy L. Moulder, Roman Yelensky, Philip J. Stephens, Razelle Kurzrock

01.12.2015 | Study protocol | Ausgabe 1/2015 Open Access

Early Palliative Care—Health services research and implementation of sustainable changes: the study protocol of the EVI project

Cornelia Meffert, Jan Gaertner, Katharina Seibel, Karin Jors, Hubert Bardenheuer, Dieter Buchheidt, Regine Mayer-Steinacker, Marén Viehrig, Christina Paul, Stephanie Stock, Carola Xander, Gerhild Becker

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Identification of markers that functionally define a quiescent multiple myeloma cell sub-population surviving bortezomib treatment

Alfred Adomako, Veronica Calvo, Noa Biran, Keren Osman, Ajai Chari, James C Paton, Adrienne W Paton, Kateri Moore, Denis M Schewe, Julio A Aguirre-Ghiso

01.12.2015 | Case report | Ausgabe 1/2015 Open Access

Psychogenic fever in a patient with small cell lung cancer: a case report

Mengdan Xu, Xiaoye Zhang, Zhaoguo Xu, Guoyuan Cui, Li Yu, Xiaoying Qi, Jia Lin, Yan Liu

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Childhood cancer mortality in Japan, 1980–2013

Limin Yang, Junichiro Fujimoto

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Lymph node density as a prognostic variable in node-positive bladder cancer: a meta-analysis

Ja Hyeon Ku, Minyong Kang, Hyung Suk Kim, Chang Wook Jeong, Cheol Kwak, Hyeon Hoe Kim

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

miR-16 promotes the apoptosis of human cancer cells by targeting FEAT

Hongwei Liang, Zheng Fu, Xueyuan Jiang, Nan Wang, Feng Wang, Xueliang Wang, Suyang Zhang, Yanbo Wang, Xin Yan, Wen-xian Guan, Chen-Yu Zhang, Ke Zen, Yujing Zhang, Xi Chen, Guangxin Zhou

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Consumption of hot beverages and foods and the risk of esophageal cancer: a meta-analysis of observational studies

Yawen Chen, Yeqing Tong, Chen Yang, Yong Gan, Huilian Sun, Huashan Bi, Shiyi Cao, Xiaoxv Yin, Zuxun Lu

01.12.2015 | Case report | Ausgabe 1/2015 Open Access

The diagnostic challenge of pulmonary tumour thrombotic microangiopathy as a presentation for metastatic gastric cancer: a case report and review of the literature

Andrew LK. Ho, Patryk Szulakowsi, Waria HS. Mohamid

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

c-Met in esophageal squamous cell carcinoma: an independent prognostic factor and potential therapeutic target

Yohei Ozawa, Yasuhiro Nakamura, Fumiyoshi Fujishima, Saulo JA Felizola, Kenichiro Takeda, Hiroshi Okamoto, Ken Ito, Hirotaka Ishida, Takuro Konno, Takashi Kamei, Go Miyata, Noriaki Ohuchi, Hironobu Sasano

01.12.2015 | Study protocol | Ausgabe 1/2015 Open Access

Randomized phase II study of S-1 dosing schedule for resected colorectal cancer

Chu Matsuda, Mamoru Uemura, Ken Nakata, Tatsushi Shingai, Junichi Nishimura, Taishi Hata, Masakazu Ikenaga, Ichiro Takemasa, Tsunekazu Mizushima, Takeshi Kato, Masataka Ikeda, Masayuki Ohue, Kohei Murata, Junichi Hasegawa, Taroh Satoh, Hirofumi Yamamoto, Mitsugu Sekimoto, Riichiro Nezu, Yuichiro Doki, Masaki Mori

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

TIF1γ interferes with TGFβ1/SMAD4 signaling to promote poor outcome in operable breast cancer patients

Loay Kassem, Mathieu Deygas, Laurent Fattet, Jonathan Lopez, Thibaut Goulvent, Emilie Lavergne, Sylvie Chabaud, Nicolas Carrabin, Nicolas Chopin, Thomas Bachelot, Germain Gillet, Isabelle Treilleux, Ruth Rimokh

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Identification and validation of dysregulated MAPK7 (ERK5) as a novel oncogenic target in squamous cell lung and esophageal carcinoma

Paul R. Gavine, Mei Wang, Dehua Yu, Eva Hu, Chunlei Huang, Jenny Xia, Xinying Su, Joan Fan, Tianwei Zhang, Qingqing Ye, Li Zheng, Guanshan Zhu, Ziliang Qian, Qingquan Luo, Ying Yong Hou, Qunsheng Ji

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Vinflunine in routine clinical practice for the treatment of advanced or metastatic urothelial cell carcinoma - data from a prospective, multicenter experience

Margitta Retz, Patrick de Geeter, Peter J. Goebell, Ullrich Matz, Wito de Schultz, Axel Hegele

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Matrix metalloproteases as maestros for the dual role of LPS- and IL-10-stimulated macrophages in cancer cell behaviour

Ana P. Cardoso, Marta L. Pinto, Ana T. Pinto, Marta T. Pinto, Cátia Monteiro, Marta I. Oliveira, Susana G. Santos, João B. Relvas, Raquel Seruca, Alberto Mantovani, Marc Mareel, Mário A. Barbosa, Maria J. Oliveira

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

APC selectively mediates response to chemotherapeutic agents in breast cancer

Monica K. VanKlompenberg, Claire O. Bedalov, Katia Fernandez Soto, Jenifer R. Prosperi

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Categorical versus continuous circulating tumor cell enumeration as early surrogate marker for therapy response and prognosis during docetaxel therapy in metastatic prostate cancer patients

Mark Thalgott, Brigitte Rack, Matthias Eiber, Michael Souvatzoglou, Matthias M. Heck, Caroline Kronester, Ulrich Andergassen, Victoria Kehl, Bernd J. Krause, Jurgen E. Gschwend, Margitta Retz, Roman Nawroth

01.12.2015 | Study protocol | Ausgabe 1/2015 Open Access

Cohort profile: cholangiocarcinoma screening and care program (CASCAP)

Narong Khuntikeo, Nittaya Chamadol, Puangrat Yongvanit, Watcharin Loilome, Nisana Namwat, Paiboon Sithithaworn, Ross H. Andrews, Trevor N. Petney, Supannee Promthet, Kavin Thinkhamrop, Chaiwat Tawarungruang, Bandit Thinkhamrop, on behalf of the CASCAP investigators

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Intratumor cholesteryl ester accumulation is associated with human breast cancer proliferation and aggressive potential: a molecular and clinicopathological study

David de Gonzalo-Calvo, Laura López-Vilaró, Laura Nasarre, Maitane Perez-Olabarria, Tania Vázquez, Daniel Escuin, Lina Badimon, Agusti Barnadas, Enrique Lerma, Vicenta Llorente-Cortés

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

MiR-223 targeting MAFB suppresses proliferation and migration of nasopharyngeal carcinoma cells

Wanyong Yang, Xi Lan, Dongmin Li, Tao Li, Shemin Lu

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Combined inhibition of the cell cycle related proteins Wee1 and Chk1/2 induces synergistic anti-cancer effect in melanoma

Gry Irene Magnussen, Elisabeth Emilsen, Karianne Giller Fleten, Birgit Engesæter, Viola Nähse-Kumpf, Roar Fjær, Ana Slipicevic, Vivi Ann Flørenes

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Enhanced caveolin-1 expression increases migration, anchorage-independent growth and invasion of endometrial adenocarcinoma cells

Natalia Diaz-Valdivia, Denisse Bravo, Hernán Huerta, Soledad Henriquez, Fernando Gabler, Margarita Vega, Carmen Romero, Claudia Calderon, Gareth I. Owen, Lisette Leyton, Andrew F. G. Quest

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Cytotoxic effects of replication-competent adenoviruses on human esophageal carcinoma are enhanced by forced p53 expression

Shan Yang, Kiyoko Kawamura, Shinya Okamoto, Suguru Yamauchi, Masato Shingyoji, Ikuo Sekine, Hiroshi Kobayashi, Yuji Tada, Koichiro Tatsumi, Kenzo Hiroshima, Hideaki Shimada, Masatoshi Tagawa

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Conventional transarterial chemoembolization versus drug-eluting bead transarterial chemoembolization for the treatment of hepatocellular carcinoma

Roman Kloeckner, Arndt Weinmann, Friederike Prinz, Daniel Pinto dos Santos, Christian Ruckes, Christoph Dueber, Michael Bernhard Pitton

01.12.2015 | Technical advance | Ausgabe 1/2015 Open Access

A 3D-microtissue-based phenotypic screening of radiation resistant tumor cells with synchronized chemotherapeutic treatment

Nataša Anastasov, Ines Höfig, Vanja Radulović, Simon Ströbel, Michael Salomon, Jan Lichtenberg, Ina Rothenaigner, Kamyar Hadian, Jens M. Kelm, Christian Thirion, Michael J. Atkinson

01.12.2015 | Study protocol | Ausgabe 1/2015 Open Access

Study design and rationale for a randomised, placebo-controlled, double-blind study to assess the efficacy of selumetinib (AZD6244; ARRY-142886) in combination with dacarbazine in patients with metastatic uveal melanoma (SUMIT)

Richard D. Carvajal, Gary K. Schwartz, Helen Mann, Ian Smith, Paul D. Nathan

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

The prognostic role of HER2 expression in ductal breast carcinoma in situ (DCIS); a population-based cohort study

Signe Borgquist, Wenjing Zhou, Karin Jirström, Rose-Marie Amini, Thomas Sollie, Therese Sørlie, Carl Blomqvist, Salma Butt, Fredrik Wärnberg

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

microRNA-34a inhibits epithelial mesenchymal transition in human cholangiocarcinoma by targeting Smad4 through transforming growth factor-beta/Smad pathway

Pengfei Qiao, Guodong Li, Wen Bi, Lianmeng Yang, Lei Yao, Dequan Wu

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

TRIM8 downregulation in glioma affects cell proliferation and it is associated with patients survival

Lucia Micale, Carmela Fusco, Andrea Fontana, Raffaela Barbano, Bartolomeo Augello, Pasquelena De Nittis, Massimiliano Copetti, Maria Teresa Pellico, Barbara Mandriani, Dario Cocciadiferro, Paola Parrella, Vito Michele Fazio, Lucia Maria Cecilia Dimitri, Vincenzo D’Angelo, Chiara Novielli, Lidia Larizza, Antonio Daga, Giuseppe Merla

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

The role of the REG4 gene and its encoding product in ovarian epithelial carcinoma

Shuo Chen, Wen-Feng Gou, Shuang Zhao, Zhe-Feng Niu, Yang Zhao, Yasuo Takano, Hua-Chuan Zheng

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

A microRNA molecular modeling extension for prediction of colorectal cancer treatment

Jian Li, Ulrich R. Mansmann

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Gene expression profiling leads to discovery of correlation of matrix metalloproteinase 11 and heparanase 2 in breast cancer progression

Junjie Fu, Ravil Khaybullin, Yanping Zhang, Amy Xia, Xin Qi

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

The combination of methylsulfonylmethane and tamoxifen inhibits the Jak2/STAT5b pathway and synergistically inhibits tumor growth and metastasis in ER-positive breast cancer xenografts

Nipin SP, Pramod Darvin, Young Beom Yoo, Youn Hee Joung, Dong Young Kang, Don Nam Kim, Tae Sook Hwang, Sang Yoon Kim, Wan Seop Kim, Hak Kyo Lee, Byung Wook Cho, Heui Soo Kim, Kyung Do Park, Jong Hwan Park, Soung Hoon Chang, Young Mok Yang

01.12.2015 | Study protocol | Ausgabe 1/2015 Open Access

Concept and design of a nationwide prospective feasibility/efficacy/safety study of weekly paclitaxel for patients with pathologically confirmed anaplastic thyroid cancer (ATCCJ-PTX-P2)

Naoyoshi Onoda, Iwao Sugitani, Takuya Higashiyama, Hisato Hara, Ken-ichi Ito, Makoto Kammori, Kiminori Sugino, Shinichi Suzuki, Kazuhisa Toda, Akira Yoshida, Akira Miyauchi

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Constitutive expression of Bcl-2 induces epithelial-Mesenchymal transition in mammary epithelial cells

Juan An, Jin Lv, Aimin Li, Junxiao Qiao, Liang Fang, Zhihua Li, Bo Li, Wei Zhao, Huoming Chen, Liying Wang

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Effect of sulfasalazine on human neuroblastoma: analysis of sepiapterin reductase (SPR) as a new therapeutic target

Lisette P. Yco, Dirk Geerts, Gabor Mocz, Jan Koster, André S. Bachmann

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

A cross-sectional study of high-risk human papillomavirus clustering and cervical outcomes in HIV-infected women in Rio de Janeiro, Brazil

Jessica L. Castilho, José Eduardo Levi, Paula M. Luz, Mary Catherine Cambou, Tazio Vanni, Angela de Andrade, Mônica Derrico, Valdiléa G. Veloso, Beatriz Grinsztejn, Ruth K. Friedman

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Pharmacological targeting of valosin containing protein (VCP) induces DNA damage and selectively kills canine lymphoma cells

Marie-Ève Nadeau, Charlène Rico, Mayra Tsoi, Mélanie Vivancos, Sabin Filimon, Marilène Paquet, Derek Boerboom

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

LTA + 252A > G polymorphism is associated with risk of nasal NK/T-cell lymphoma in a Chinese population: a case-control study

Sensen Cheng, Jianzhong Li, Wenjian Liu, Chengxiang Liu, Lei Su, Xiuchun Liu, Liangjun Guo, Yuan Ma, Bao Song, Jie Liu

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Quantitative proteomic analysis shows differentially expressed HSPB1 in glioblastoma as a discriminating short from long survival factor and NOVA1 as a differentiation factor between low-grade astrocytoma and oligodendroglioma

Marcela Gimenez, Suely Kazue Nagahashi Marie, Sueli Oba-Shinjo, Miyuki Uno, Clarice Izumi, João Bosco Oliveira, Jose Cesar Rosa

01.12.2015 | Study protocol | Ausgabe 1/2015 Open Access

Investigating the performance and cost-effectiveness of the simple ultrasound-based rules compared to the risk of malignancy index in the diagnosis of ovarian cancer (SUBSONiC-study): protocol of a prospective multicenter cohort study in the Netherlands

Evelyne MJ Meys, Iris JG Rutten, Roy FPM Kruitwagen, Brigitte F Slangen, Martin GM Bergmans, Helen JMM Mertens, Ernst Nolting, Dieuwke Boskamp, Regina GH Beets-Tan, Toon van Gorp

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Menacalc, a quantitative method of metastasis assessment, as a prognostic marker for axillary node-negative breast cancer

Catherine L. Forse, Seema Agarwal, Dushanthi Pinnaduwage, Frank Gertler, John S. Condeelis, Juan Lin, Xiaonan Xue, Kimberly Johung, Anna Marie Mulligan, Thomas E. Rohan, Shelley B. Bull, Irene L. Andrulis

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

The prognostic impact of mutations in spliceosomal genes for myelodysplastic syndrome patients without ring sideroblasts

Min-Gu Kang, Hye-Ran Kim, Bo-Young Seo, Jun Hyung Lee, Seok-Yong Choi, Soo-Hyun Kim, Jong-Hee Shin, Soon-Pal Suh, Jae-Sook Ahn, Myung-Geun Shin

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Distribution of cervical intraepithelial neoplasia on the cervix in Chinese women: pooled analysis of 19 population based screening studies

Yu-qian Zhao, Irene J. Chang, Fang-hui Zhao, Shang-ying Hu, Jennifer S. Smith, Xun Zhang, Shu-min Li, Ping Bai, Wen-hua Zhang, You-lin Qiao

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Multimodality therapy approaches, local and systemic treatment, compared with chemotherapy alone in recurrent glioblastoma

Marta Scorsetti, Pierina Navarria, Federico Pessina, Anna Maria Ascolese, Giuseppe D’Agostino, Stefano Tomatis, Fiorenza De Rose, Elisa Villa, Giulia Maggi, Matteo Simonelli, Elena Clerici, Riccardo Soffietti, Armando Santoro, Luca Cozzi, Lorenzo Bello

01.12.2015 | Study protocol | Ausgabe 1/2015 Open Access

PIpelle Prospective ENDOmetrial carcinoma (PIPENDO) study, pre-operative recognition of high risk endometrial carcinoma: a multicentre prospective cohort study

Nicole C. M. Visser, Johan Bulten, Anneke A. M. van der Wurff, Erik A. Boss, Carolien M. Bronkhorst, Harrie W. H. Feijen, Joke E. Haartsen, Hilde A. D. M. van Herk, Ineke M. de Kievit, Paul J. J. M. Klinkhamer, Brenda M. Pijlman, Marc P. M. L. Snijders, Ingrid Vandenput, M. Caroline Vos, Peter E. J. de Wit, Lonneke V. van de Poll-Franse, Leon F.A.G. Massuger, Johanna M. A. Pijnenborg

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

The truncated splice variant of peroxisome proliferator-activated receptor alpha, PPARα-tr, autonomously regulates proliferative and pro-inflammatory genes

Maria Thomas, Christine Bayha, Kathrin Klein, Simon Müller, Thomas S. Weiss, Matthias Schwab, Ulrich M. Zanger

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Anticancer drug sensitivity prediction in cell lines from baseline gene expression through recursive feature selection

Zuoli Dong, Naiqian Zhang, Chun Li, Haiyun Wang, Yun Fang, Jun Wang, Xiaoqi Zheng

01.12.2015 | Study protocol | Ausgabe 1/2015 Open Access

Helping cancer patients quit smoking by increasing their risk perception: a study protocol of a cluster randomized controlled trial

William H.C. Li, Sophia S.C. Chan, Kelvin M. P. Wang, T.H. Lam

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Estrogen receptor α enhances the transcriptional activity of ETS-1 and promotes the proliferation, migration and invasion of neuroblastoma cell in a ligand dependent manner

Peng Cao, Fan Feng, Guofu Dong, Chunyong Yu, Sizhe Feng, Erlin Song, Guobing Shi, Yong Liang, Guobiao Liang

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Inflammation-regulating factors in ascites as predictive biomarkers of drug resistance and progression-free survival in serous epithelial ovarian cancers

Denis Lane, Isabelle Matte, Perrine Garde-Granger, Claude Laplante, Alex Carignan, Claudine Rancourt, Alain Piché

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Preoperative serum 8-hydroxydeoxyguanosine is associated with chemoresistance and is a powerful prognostic factor in endometrioid-type epithelial ovarian cancer

Marjo Pylväs-Eerola, Peeter Karihtala, Ulla Puistola

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

TRAIL-receptor preferences in pancreatic cancer cells revisited: Both TRAIL-R1 and TRAIL-R2 have a licence to kill

Andrea Mohr, Rui Yu, Ralf M. Zwacka

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Evaluation of the efficacy and safety of lanreotide in combination with targeted therapies in patients with neuroendocrine tumours in clinical practice: a retrospective cross-sectional analysis

Jaume Capdevila, Isabel Sevilla, Vicente Alonso, Luís Antón Aparicio, Paula Jiménez Fonseca, Enrique Grande, Juan José Reina, José Luís Manzano, Juan Domingo Alonso Lájara, Jorge Barriuso, Daniel Castellano, Javier Medina, Carlos López, Ángel Segura, Sergio Carrera, Guillermo Crespo, José Fuster, Javier Munarriz, Pilar García Alfonso

01.12.2015 | Study protocol | Ausgabe 1/2015 Open Access

STRATEGIC-1: A multiple-lines, randomized, open-label GERCOR phase III study in patients with unresectable wild-type RAS metastatic colorectal cancer

Benoist Chibaudel, Franck Bonnetain, Christophe Tournigand, Marine Hug de Larauze, Armand de Gramont, Pierre Laurent-Puig, Jérôme Paget, Alexandra Hadengue, Dominique Notelet, Magdalena Benetkiewicz, Thierry André, Aimery de Gramont

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Variations of BRAF mutant allele percentage in melanomas

Zofia Hélias-Rodzewicz, Elisa Funck-Brentano, Laure Baudoux, Chan Kwon Jung, Ute Zimmermann, Cristi Marin, Thierry Clerici, Catherine Le Gall, Frédérique Peschaud, Valérie Taly, Philippe Saiag, Jean-François Emile

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

The different role of intratumoral and peritumoral lymphangiogenesis in gastric cancer progression and prognosis

Kyung Ho Pak, Ara Jo, Hye Ji Choi, Younghee Choi, Hyunki Kim, Jae-Ho Cheong

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

MiR-190b, the highest up-regulated miRNA in ERα-positive compared to ERα-negative breast tumors, a new biomarker in breast cancers?

Geraldine Cizeron-Clairac, François Lallemand, Sophie Vacher, Rosette Lidereau, Ivan Bieche, Celine Callens

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Primary care characteristics and stage of cancer at diagnosis using data from the national cancer registration service, quality outcomes framework and general practice information

Rebecca Maclean, Mona Jeffreys, Alex Ives, Tim Jones, Julia Verne, Yoav Ben-Shlomo

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

The Functionality Assessment Flowchart (FAF): a new simple and reliable method to measure performance status with a high percentage of agreement between observers

Carlos Eduardo Paiva, Felipe Augusto Ferreira Siquelli, Henrique Amorim Santos, Marina Moreira Costa, Daniella Ramone Massaro, Domício Carvalho Lacerda, João Soares Nunes, Cristiano de Pádua Souza, Bianca Sakamoto Ribeiro Paiva

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

The expression of aldehyde dehydrogenase 1 (ALDH1) in ovarian carcinomas and its clinicopathological associations: a retrospective study

Ruixia Huang, Xiaoran Li, Ruth Holm, Claes G. Trope, Jahn M. Nesland, Zhenhe Suo

01.12.2015 | Study protocol | Ausgabe 1/2015 Open Access

ComOn Coaching: Study protocol of a randomized controlled trial to assess the effect of a varied number of coaching sessions on transfer into clinical practice following communication skills training

Marcelo Niglio de Figueiredo, Bärbel Rodolph, Carma L Bylund, Tanja Goelz, Pia Heußner, Heribert Sattel, Kurt Fritzsche, Alexander Wuensch

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Enhanced efficacy of photodynamic therapy by inhibiting ABCG2 in colon cancers

Ju Hee Kim, Jae Myung Park, Yoon Jin Roh, In-Wook Kim, Tayyaba Hasan, Myung-Gyu Choi

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Enhancing adherence in trials promoting change in diet and physical activity in individuals with a diagnosis of colorectal adenoma; a systematic review of behavioural intervention approaches

Deborah McCahon, Amanda J. Daley, Janet Jones, Richard Haslop, Arjun Shajpal, Aliki Taylor, Sue Wilson, George Dowswell

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Comparative microRNA profiling of sporadic and BRCA1 associated basal-like breast cancers

Max Yan, Kristy Shield-Artin, David Byrne, Siddhartha Deb, Nic Waddell, Izhak Haviv, Stephen B Fox, kConFab Investigators, kConFab

01.12.2015 | Case report | Ausgabe 1/2015 Open Access

Acrokeratosis paraneoplastica in serous ovarian carcinoma: case report

Aline Hempen, Eleftherios P Samartzis, Jivko Kamarachev, Daniel Fink, Konstantin J Dedes

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Polish experience of lenalidomide in the treatment of lower risk myelodysplastic syndrome with isolated del(5q)

Aleksandra Butrym, Ewa Lech-Maranda, Elżbieta Patkowska, Beata Kumiega, Maria Bieniaszewska, Andrzej Mital, Krzysztof Madry, Tigran Torosian, Ryszard Wichary, Justyna Rybka, Krzysztof Warzocha, Grzegorz Mazur

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Methylation-associated Has-miR-9 deregulation in paclitaxel- resistant epithelial ovarian carcinoma

Xiao Li, Qianqian Pan, Xiaoyun Wan, Yuyan Mao, Weiguo Lu, Xing Xie, Xiaodong Cheng

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

The effectiveness and safety of platinum-based pemetrexed and platinum-based gemcitabine treatment in patients with malignant pleural mesothelioma

Guntulu Ak, Selma Metintas, Muhittin Akarsu, Muzaffer Metintas

01.12.2015 | Study protocol | Ausgabe 1/2015 Open Access

Neoadjuvant FOLFOX 4 versus FOLFOX 4 with Cetuximab versus immediate surgery for high-risk stage II and III colon cancers: a multicentre randomised controlled phase II trial – the PRODIGE 22 - ECKINOXE trial

Mehdi Karoui, Anne Rullier, Alain Luciani, Franck Bonnetain, Marie-Luce Auriault, Antony Sarran, Geneviève Monges, Hervé Trillaud, Karine Le Malicot, Karen Leroy, Iradj Sobhani, Armelle Bardier, Marie Moreau, Isabelle Brindel, Jean François Seitz, Julien Taieb

01.12.2015 | Study protocol | Ausgabe 1/2015 Open Access

The Breast Cancer to Bone (B2B) Metastases Research Program: a multi-disciplinary investigation of bone metastases from breast cancer

Nigel T. Brockton, Stephanie J. Gill, Stephanie L. Laborge, Alexander H. G. Paterson, Linda S. Cook, Hans J. Vogel, Carrie S. Shemanko, David A. Hanley, Anthony M. Magliocco, Christine M. Friedenreich

01.12.2015 | Case report | Ausgabe 1/2015 Open Access

The combination of intravenous Reolysin and gemcitabine induces reovirus replication and endoplasmic reticular stress in a patient with KRAS-activated pancreatic cancer

Devalingam Mahalingam, Sukeshi Patel, Gerard Nuovo, George Gill, Giovanni Selvaggi, Matt Coffey, Steffan T. Nawrocki

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Acquired genetic alterations in tumor cells dictate the development of high-risk neuroblastoma and clinical outcomes

Faizan H. Khan, Vijayabaskar Pandian, Satishkumar Ramraj, Mohan Natarajan, Sheeja Aravindan, Terence S. Herman, Natarajan Aravindan

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Noncompliance to guidelines in head and neck cancer treatment; associated factors for both patient and physician

Emilie A. C. Dronkers, Steven W. Mes, Marjan H. Wieringa, Marc P. van der Schroeff, Robert J. Baatenburg de Jong

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Pan-cancer analysis of TCGA data reveals notable signaling pathways

Richard Neapolitan, Curt M. Horvath, Xia Jiang

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Locally ablative treatment of breast cancer liver metastases: identification of factors influencing survival (the Mammary Cancer Microtherapy and Interventional Approaches (MAMMA MIA) study)

Max Seidensticker, Benjamin Garlipp, Sophia Scholz, Konrad Mohnike, Felix Popp, Ingo Steffen, Ricarda Seidensticker, Patrick Stübs, Maciej Pech, Maciej PowerskI, Peter Hass, Serban-Dan Costa, Holger Amthauer, Christiane Bruns, Jens Ricke

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Expression of pre-selected TMEMs with predicted ER localization as potential classifiers of ccRCC tumors

Tomasz Wrzesiński, Malgorzata Szelag, Wojciech A. Cieślikowski, Agnieszka Ida, Rachel Giles, Elżbieta Zodro, Joanna Szumska, Joanna Poźniak, Zbigniew Kwias, Hans A.R. Bluyssen, Joanna Wesoly

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Prospective cohort study using the breast cancer spheroid model as a predictor for response to neoadjuvant therapy – the SpheroNEO study

Kathrin Halfter, Nina Ditsch, Hans-Christian Kolberg, Holger Fischer, Tanja Hauzenberger, Franz Edler von Koch, Ingo Bauerfeind, Gunter von Minckwitz, Ilona Funke, Alexander Crispin, Barbara Mayer, Behalf of the SpheroNEO Study Group

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Ki-67 as a prognostic marker in early-stage non-small cell lung cancer in Asian patients: a meta-analysis of published studies involving 32 studies

Song Wen, Wei Zhou, Chun-ming Li, Juan Hu, Xiao-ming Hu, Ping Chen, Guo-liang Shao, Wu-hua Guo

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

The prognostic significance of the postoperative prognostic nutritional index in patients with colorectal cancer

Masatsune Shibutani, Kiyoshi Maeda, Hisashi Nagahara, Hiroshi Ohtani, Yasuhito Iseki, Tetsuro Ikeya, Kenji Sugano, Kosei Hirakawa

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

A new anti-glioma therapy, AG119: pre-clinical assessment in a mouse GL261 glioma model

Rheal A. Towner, Michael Ihnat, Debra Saunders, Anja Bastian, Nataliya Smith, Roheeth Kumar Pavana, Aleem Gangjee

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Spectrum and frequencies of BRCA1/2 mutations in Bulgarian high risk breast cancer patients

Rumyana Ivanova Dodova, Atanaska Velichkova Mitkova, Daniela Rosenova Dacheva, Lina Basam Hadjo, Alexandrina Ivanova Vlahova, Margarita Stoyanova Taushanova - Hadjieva, Spartak Stoyanov Valev, Marija Mitko Caulevska, Stanislava Dimitrova Popova, Ivan Emilov Popov, Tihomir Iliichev Dikov, Theophil Angelov Sedloev, Atanas Stefanov Ionkov, Konstanta Velinova Timcheva, Svetlana Liubomirova Christova, Ivo Marinov Kremensky, Vanio Ivanov Mitev, Radka Petrova Kaneva

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Expression of an estrogen-regulated variant transcript of the peroxisomal branched chain fatty acid oxidase ACOX2 in breast carcinomas

Sunniva Stordal Bjørklund, Vessela N. Kristensen, Michael Seiler, Surendra Kumar, Grethe I. Grenaker Alnæs, Yao Ming, John Kerrigan, Bjørn Naume, Ravi Sachidanandam, Gyan Bhanot, Anne-Lise Børresen-Dale, Shridar Ganesan

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

A small molecular agent YL529 inhibits VEGF-D-induced lymphangiogenesis and metastasis in preclinical tumor models in addition to its known antitumor activities

Youzhi Xu, Wenjie Lu, Peng Yang, Wen Peng, Chunting Wang, Manli Li, Yan Li, Guobo Li, Nana Meng, Hongjun Lin, Lixin Kan, Siying Wang, Shengyong Yang, Luoting Yu, YingLan Zhao

01.12.2015 | Study protocol | Ausgabe 1/2015 Open Access

Audiovisual biofeedback breathing guidance for lung cancer patients receiving radiotherapy: a multi-institutional phase II randomised clinical trial

Sean Pollock, Ricky O’Brien, Kuldeep Makhija, Fiona Hegi-Johnson, Jane Ludbrook, Angela Rezo, Regina Tse, Thomas Eade, Roland Yeghiaian-Alvandi, Val Gebski, Paul J Keall

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

A potential small-molecule synthetic antilymphangiogenic agent norcantharidin inhibits tumor growth and lymphangiogenesis of human colonic adenocarcinomas through blocking VEGF-A,-C,-D/VEGFR-2,-3 “multi-points priming” mechanisms in vitro and in vivo

Xin-Ping Li, Wei Jing, Jian-Jun Sun, Zhong-Yan Liu, Jing-Tao Zhang, Wei Sun, Wei Zhu, Yue-Zu Fan

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

STAT3 polymorphism and Helicobacter pylori CagA strains with higher number of EPIYA-C segments independently increase the risk of gastric cancer

Gifone A Rocha, Andreia MC Rocha, Adriana D Gomes, César LL Faria Jr, Fabrício F Melo, Sérgio A Batista, Viviane C Fernandes, Nathálie BF Almeida, Kádima N Teixeira, Kátia S Brito, Dulciene Maria Magalhães Queiroz

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Targeting mTOR/p70S6K/glycolysis signaling pathway restores glucocorticoid sensitivity to 4E-BP1 null Burkitt Lymphoma

Ling Gu, Liping Xie, Chuan Zuo, Zhigui Ma, Yanle Zhang, Yiping Zhu, Ju Gao

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Tumour shrinkage at 6 weeks predicts favorable clinical outcomes in a phase III study of gemcitabine and oxaliplatin with or without erlotinib for advanced biliary tract cancer

Seung Tae Kim, Kee-Taek Jang, Su Jin Lee, Hye-Lim Jang, Jeeyun Lee, Se Hoon Park, Young Suk Park, Ho Yeong Lim, Won Ki Kang, Joon Oh Park

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Nrf2 is a potential prognostic marker and promotes proliferation and invasion in human hepatocellular carcinoma

Mingxin Zhang, Chao Zhang, Lingmin Zhang, Qi Yang, Suna Zhou, Qinsheng Wen, Jingjie Wang

01.12.2015 | Study protocol | Ausgabe 1/2015 Open Access

TOPGEAR: a randomised phase III trial of perioperative ECF chemotherapy versus preoperative chemoradiation plus perioperative ECF chemotherapy for resectable gastric cancer (an international, intergroup trial of the AGITG/TROG/EORTC/NCIC CTG)

Trevor Leong, B Mark Smithers, Michael Michael, Val Gebski, Alex Boussioutas, Danielle Miller, John Simes, John Zalcberg, Karin Haustermans, Florian Lordick, Christoph Schuhmacher, Carol Swallow, Gail Darling, Rebecca Wong

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Relationship between circulating tumor cells and epithelial to mesenchymal transition in early breast cancer

M. Mego, Z. Cierna, P. Janega, M. Karaba, G. Minarik, J. Benca, T. Sedlácková, G. Sieberova, P. Gronesova, D. Manasova, D. Pindak, J. Sufliarsky, L. Danihel, JM Reuben, J. Mardiak

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Monitoring therapeutic efficacy of sunitinib using [18F]FDG and [18F]FMISO PET in an immunocompetent model of luminal B (HER2-positive)-type mammary carcinoma

Benoît Thézé, Nicholas Bernards, Audrey Beynel, Stephan Bouet, Bertrand Kuhnast, Irène Buvat, Bertrand Tavitian, Raphaël Boisgard

01.12.2015 | Case report | Ausgabe 1/2015 Open Access

Collapsing focal segmental glomerulosclerosis following long-term treatment with oral ibandronate: case report and review of literature

Ning Jia, Fionnuala C. Cormack, Bin Xie, Zita Shiue, Behzad Najafian, Julie R. Gralow

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Overexpression of Class III β-tubulin, Sox2, and nuclear Survivin is predictive of taxane resistance in patients with stage III ovarian epithelial cancer

Jintong Du, Bei Li, Yingli Fang, Yanguo Liu, Yang Wang, Jisheng Li, Wen Zhou, Xiuwen Wang

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Linear accelerator-based stereotactic radiosurgery in 140 brain metastases from malignant melanoma

Henrik Hauswald, Alina Stenke, Jürgen Debus, Stephanie E. Combs

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

The prognostic value of SUMO1/Sentrin specific peptidase 1 (SENP1) in prostate cancer is limited to ERG-fusion positive tumors lacking PTEN deletion

Christoph Burdelski, Devi Menan, Maria Christina Tsourlakis, Martina Kluth, Claudia Hube-Magg, Nathaniel Melling, Sarah Minner, Christina Koop, Markus Graefen, Hans Heinzer, Corinna Wittmer, Guido Sauter, Ronald Simon, Thorsten Schlomm, Stefan Steurer, Till Krech

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Whole-exome sequencing of a rare case of familial childhood acute lymphoblastic leukemia reveals putative predisposing mutations in Fanconi anemia genes

Jean-François Spinella, Jasmine Healy, Virginie Saillour, Chantal Richer, Pauline Cassart, Manon Ouimet, Daniel Sinnett

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Functional role of miR-10b in tamoxifen resistance of ER-positive breast cancer cells through down-regulation of HDAC4

Aamir Ahmad, Kevin R. Ginnebaugh, Shuping Yin, Aliccia Bollig-Fischer, Kaladhar B. Reddy, Fazlul H. Sarkar

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

The burden of cervical pre-cancer and cancer in HIV positive women in Zambia: a modeling study

Allen C. Bateman, Katundu Katundu, Mulindi H. Mwanahamuntu, Sharon Kapambwe, Vikrant V. Sahasrabuddhe, Michael L. Hicks, Benjamin H. Chi, Jeffrey S. A. Stringer, Groesbeck P. Parham, Carla J. Chibwesha

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Functional microRNA high throughput screening reveals miR-9 as a central regulator of liver oncogenesis by affecting the PPARA-CDH1 pathway

Alexandra Drakaki, Maria Hatziapostolou, Christos Polytarchou, Christina Vorvis, George A. Poultsides, John Souglakos, Vassilis Georgoulias, Dimitrios Iliopoulos

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Early increase in circulating carbonic anhydrase IX during neoadjuvant treatment predicts favourable outcome in locally advanced rectal cancer

Helga Helseth Hektoen, Kjersti Flatmark, Yvonne Andersson, Svein Dueland, Kathrine Røe Redalen, Anne Hansen Ree

01.12.2015 | Study protocol | Ausgabe 1/2015 Open Access

Association of sarcopenia and observed physical performance with attainment of multidisciplinary team planned treatment in non-small cell lung cancer: an observational study protocol

Jemima T. Collins, Simon Noble, John Chester, Helen E. Davies, William D. Evans, Jason Lester, Diane Parry, Rebecca J. Pettit, Anthony Byrne

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

High basal Wnt signaling is further induced by PI3K/mTor inhibition but sensitive to cSRC inhibition in mammary carcinoma cell lines with HER2/3 overexpression

Elpetra P. M. Timmermans-Sprang, Ana Gracanin, Jan A. Mol

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Digital imaging in the immunohistochemical evaluation of the proliferation markers Ki67, MCM2 and Geminin, in early breast cancer, and their putative prognostic value

Shalaka Joshi, Johnathan Watkins, Patrycja Gazinska, John P. Brown, Cheryl E. Gillett, Anita Grigoriadis, Sarah E. Pinder

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Identifying novel hypoxia-associated markers of chemoresistance in ovarian cancer

Lynda M. McEvoy, Sharon A. O’Toole, Cathy D. Spillane, Cara M. Martin, Michael F. Gallagher, Britta Stordal, Gordon Blackshields, Orla Sheils, John J. O’Leary

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Elevated C1orf63 expression is correlated with CDK10 and predicts better outcome for advanced breast cancers: a retrospective study

Chao-Qun Hong, Fan Zhang, Yan-Jie You, Wei-Li Qiu, Armando E. Giuliano, Xiao-Jiang Cui, Guo-Jun Zhang, Yu-Kun Cui

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

CD147 expression predicts biochemical recurrence after prostatectomy independent of histologic and pathologic features

Tyler M. Bauman, Jonathan A. Ewald, Wei Huang, William A. Ricke

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

GTSE1 expression represses apoptotic signaling and confers cisplatin resistance in gastric cancer cells

Vinod Vijay Subhash, Shi Hui Tan, Woei Loon Tan, Mei Shi Yeo, Chen Xie, Foong Ying Wong, Zee Ying Kiat, Robert Lim, Wei Peng Yong

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Lymphocyte-specific protein tyrosine kinase (Lck) interacts with CR6-interacting factor 1 (CRIF1) in mitochondria to repress oxidative phosphorylation

Shahrooz Vahedi, Fu-Yu Chueh, Bala Chandran, Chao-Lan Yu

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

IL6 secreted by Ewing sarcoma tumor microenvironment confers anti-apoptotic and cell-disseminating paracrine responses in Ewing sarcoma cells

Andrej Lissat, Mandy Joerschke, Dheeraj A. Shinde, Till Braunschweig, Angelina Meier, Anna Makowska, Rachel Bortnick, Philipp Henneke, Georg Herget, Thomas A. Gorr, Udo Kontny

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

P-glycoprotein confers acquired resistance to 17-DMAG in lung cancers with an ALK rearrangement

Hee Joung Kim, Kye Young Lee, Young Whan Kim, Yun Jung Choi, Jung-Eun Lee, Chang Min Choi, In-Jeoung Baek, Jin Kyung Rho, Jae Cheol Lee

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Breast cancer survivors’ recollection of their illness and therapy seven years after enrolment into a randomised controlled clinical trial

Patricia Lindberg, Michael Koller, Brunhilde Steinger, Wilfried Lorenz, Jeremy C. Wyatt, Elisabeth C. Inwald, Monika Klinkhammer-Schalke

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Superior efficacy of rituximab-based chemoimmunotherapy as an initial therapy in newly diagnosed patients with B cell indolent lymphomas: long-term results from a single center in China

Zengjun Li, Fei Li, Shuhua Yi, Zhimin Gu, Zhen Yu, Yan Xu, Xiaoyan Feng, Wei Liu, Dehui Zou, Junyuan Qi, Fenghuang Zhan, Lugui Qiu

01.12.2015 | Study protocol | Ausgabe 1/2015 Open Access

Laparoscopic versus open gastrectomy for gastric cancer, a multicenter prospectively randomized controlled trial (LOGICA-trial)

Leonie Haverkamp, Hylke JF Brenkman, Maarten FJ Seesing, Suzanne S Gisbertz, Mark I van Berge Henegouwen, Misha DP Luyer, Grard AP Nieuwenhuijzen, Bas PL Wijnhoven, Jan JB van Lanschot, Wobbe O de Steur, Henk H Hartgrink, Jan HMB Stoot, Karel WE Hulsewé, Ernst J Spillenaar Bilgen, Jeroen E Rütter, Ewout A Kouwenhoven, Marc J van Det, Donald L van der Peet, Freek Daams, Werner A Draaisma, Ivo AMJ Broeders, Henk F van Stel, Miangela M Lacle, Jelle P Ruurda, Richard van Hillegersberg, LOGICA study group

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Population-based SEER trend analysis of overall and cancer-specific survival in 5138 patients with gastrointestinal stromal tumor

Ulrich Güller, Ignazio Tarantino, Thomas Cerny, Bruno M. Schmied, Rene Warschkow

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Impact of delays in initiating postoperative chemoradiation while determining the MGMT promoter-methylation statuses of patients with primary glioblastoma

Sebastian Adeberg, Tilman Bostel, Semi Harrabi, Denise Bernhardt, Thomas Welzel, Wolfgang Wick, Juergen Debus, Stephanie E. Combs

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

A functional genetic variant in fragile-site gene FATS modulates the risk of breast cancer in triparous women

Fangfang Song, Jun Zhang, Li Qiu, Yawen Zhao, Pan Xing, Jiachun Lu, Kexin Chen, Zheng Li

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

XAB2 tagSNPs contribute to non-small cell lung cancer susceptibility in Chinese population

Na Pei, Lei Cao, Yingwen Liu, Jing Wu, Qinqin Song, Zhi Zhang, Juxiang Yuan, Xuemei Zhang

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

A novel cytosporone 3-Heptyl-4,6-dihydroxy-3H-isobenzofuran-1-one: synthesis; toxicological, apoptotic and immunomodulatory properties; and potentiation of mutagenic damage

Rodrigo Juliano Oliveira, Stephanie Dynczuki Navarro, Dênis Pires de Lima, Alisson Meza, João Renato Pesarini, Roberto da Silva Gomes, Caroline Bilhar Karaziack, Mariana de Oliveira Mauro, Andréa Luiza Cunha-Laura, Antônio Carlos Duenhas Monreal, Wanderson Romão, Valdemar Lacerda Júnior, Adilson Beatriz

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Neoplastic transformation of porcine mammary epithelial cells in vitro and tumor formation in vivo

A. R. Rowson-Hodel, R. Manjarin, J. F. Trott, R. D. Cardiff, A. D. Borowsky, R. C. Hovey

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Adenosine A2b receptor promotes progression of human oral cancer

Hiroki Kasama, Yosuke Sakamoto, Atsushi Kasamatsu, Atsushi Okamoto, Tomoyoshi Koyama, Yasuyuki Minakawa, Katsunori Ogawara, Hidetaka Yokoe, Masashi Shiiba, Hideki Tanzawa, Katsuhiro Uzawa

01.12.2015 | Study protocol | Ausgabe 1/2015 Open Access

Adjuvant chemotherapy with gemcitabine and cisplatin compared to observation after curative intent resection of cholangiocarcinoma and muscle invasive gallbladder carcinoma (ACTICCA-1 trial) - a randomized, multidisciplinary, multinational phase III trial

Alexander Stein, Dirk Arnold, John Bridgewater, David Goldstein, Lars Henrik Jensen, Heinz-Josef Klümpen, Ansgar W. Lohse, Björn Nashan, John Primrose, Silke Schrum, Jenny Shannon, Eik Vettorazzi, Henning Wege

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Prognostic significance of multiple kallikreins in high-grade astrocytoma

Kristen L. Drucker, Caterina Gianinni, Paul A. Decker, Eleftherios P. Diamandis, Isobel A. Scarisbrick

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

A network meta-analysis of therapeutic outcomes after new image technology-assisted transurethral resection for non-muscle invasive bladder cancer: 5-aminolaevulinic acid fluorescence vs hexylaminolevulinate fluorescence vs narrow band imaging

Joo Yong Lee, Kang Su Cho, Dong Hyuk Kang, Hae Do Jung, Jong Kyou Kwon, Cheol Kyu Oh, Won Sik Ham, Young Deuk Choi

01.12.2015 | Case report | Ausgabe 1/2015 Open Access

Durable recurrence-free survival after pneumonectomy for late lung metastasis from rectal cancer: case report with genetic and epigenetic analyses

Andrea Imperatori, Nicola Rotolo, Lorenzo Dominioni, Elisa Nardecchia, Maria Cattoni, Laura Cimetti, Cristina Riva, Fausto Sessa, Daniela Furlan

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Obatoclax is a direct and potent antagonist of membrane-restricted Mcl-1 and is synthetic lethal with treatment that induces Bim

Mai Nguyen, Regina Cencic, Franziska Ertel, Cynthia Bernier, Jerry Pelletier, Anne Roulston, John R. Silvius, Gordon C. Shore

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Limited predictive value of achieving beneficial plasma (Z)-endoxifen threshold level by CYP2D6 genotyping in tamoxifen-treated Polish women with breast cancer

Ewa E. Hennig, Magdalena Piatkowska, Jakub Karczmarski, Krzysztof Goryca, Elzbieta Brewczynska, Radoslaw Jazwiec, Anna Kluska, Robert Omiotek, Agnieszka Paziewska, Michal Dadlez, Jerzy Ostrowski

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Extracellular vesicle-mediated phenotype switching in malignant and non-malignant colon cells

Hillary E. Mulvey, Audrey Chang, Jason Adler, Michael Del Tatto, Kimberly Perez, Peter J. Quesenberry, Devasis Chatterjee

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

SDF-1alpha concentration dependent modulation of RhoA and Rac1 modifies breast cancer and stromal cells interaction

Jennifer Pasquier, Nadine Abu-Kaoud, Houari Abdesselem, Aisha Madani, Jessica Hoarau-Véchot, Hamda Al. Thawadi, Fabien Vidal, Bettina Couderc, Gilles Favre, Arash Rafii

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Satisfaction with fertility- and sexuality-related information in young women with breast cancer—ELIPPSE40 cohort

Ali Ben Charif, Anne-Déborah Bouhnik, Dominique Rey, Magali Provansal, Blandine Courbiere, Bruno Spire, Julien Mancini

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Tumor-associated macrophages in oral premalignant lesions coexpress CD163 and STAT1 in a Th1-dominated microenvironment

Kazumasa Mori, Shigeki Haraguchi, Miki Hiori, Jun Shimada, Yoshihiro Ohmori

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Texture analysis on MR images helps predicting non-response to NAC in breast cancer

N. Michoux, S. Van den Broeck, L. Lacoste, L. Fellah, C. Galant, M. Berlière, I. Leconte

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Expression and role of oncogenic miRNA-224 in esophageal squamous cell carcinoma

Xiaoyan He, Zhimei Zhang, Ming Li, Shuo Li, Lihua Ren, Hong Zhu, Bin Xiao, Ruihua Shi

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Magnolin inhibits cell migration and invasion by targeting the ERKs/RSK2 signaling pathway

Cheol-Jung Lee, Mee-Hyun Lee, Sun-Mi Yoo, Kyung-Il Choi, Ji-Hong Song, Jeong-Hoon Jang, Sei-Ryang Oh, Hyung-Won Ryu, Hye-Suk Lee, Young-Joon Surh, Yong-Yeon Cho

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

M1 and M2 macrophages derived from THP-1 cells differentially modulate the response of cancer cells to etoposide

Marie Genin, Francois Clement, Antoine Fattaccioli, Martine Raes, Carine Michiels

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Variation in guideline adherence in non-Hodgkin’s lymphoma care: impact of patient and hospital characteristics

Jozette J.C. Stienen, Rosella P.M.G. Hermens, Lianne Wennekes, Saskia A.M. van de Schans, Richard W.M. van der Maazen, Helena M. Dekker, Janine Liefers, Johan H.J.M. van Krieken, Nicole M.A. Blijlevens, Petronella B. Ottevanger, On behalf of the PEARL study group

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

In vitro engineering of human 3D chondrosarcoma: a preclinical model relevant for investigations of radiation quality impact

Dounia Houria Hamdi, Sofia Barbieri, François Chevalier, Jean-Emmanuel Groetz, Florence Legendre, Magali Demoor, Philippe Galera, Jean-Louis Lefaix, Yannick Saintigny

01.12.2015 | Study protocol | Ausgabe 1/2015 Open Access

The Kanker Nazorg Wijzer (Cancer Aftercare Guide) protocol: the systematic development of a web-based computer tailored intervention providing psychosocial and lifestyle support for cancer survivors

Roy A Willems, Catherine AW Bolman, Ilse Mesters, Iris M Kanera, Audrey AJM Beaulen, Lilian Lechner

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Moxifloxacin and ciprofloxacin induces S-phase arrest and augments apoptotic effects of cisplatin in human pancreatic cancer cells via ERK activation

Vikas Yadav, Pallavi Varshney, Sarwat Sultana, Jyoti Yadav, Neeru Saini

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

LC3B globular structures correlate with survival in esophageal adenocarcinoma

Shereen El-Mashed, Tracey R. O’Donovan, Elaine W. Kay, Ayat R. Abdallah, Mary-Clare Cathcart, Jacintha O’Sullivan, Anthony O’Grady, John Reynolds, Seamus O’Reilly, Gerald C. O’Sullivan, Sharon L. McKenna

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Radical surgery versus standard surgery for primary cytoreduction of bulky stage IIIC and IV ovarian cancer: an observational study

Yulan Ren, Rong Jiang, Sheng Yin, Chao You, Dongli Liu, Xi Cheng, Jie Tang, Rongyu Zang

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Il-6 signaling between ductal carcinoma in situ cells and carcinoma-associated fibroblasts mediates tumor cell growth and migration

Kingsley O. Osuala, Mansoureh Sameni, Seema Shah, Neha Aggarwal, Michelle L. Simonait, Omar E. Franco, Yan Hong, Simon W. Hayward, Fariba Behbod, Raymond R. Mattingly, Bonnie F. Sloane

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Somatic drivers of B-ALL in a model of ETV6-RUNX1; Pax5 +/− leukemia

Louise van der Weyden, George Giotopoulos, Kim Wong, Alistair G. Rust, Carla Daniela Robles-Espinoza, Hikari Osaki, Brian J. Huntly, David J. Adams

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Bcl2 inhibition of mitochondrial DNA repair

Maohua Xie, Paul W. Doetsch, Xingming Deng

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Knowledge and attitudes regarding medical research studies among patients with breast cancer and gynecological diseases

Michael P. Lux, Thomas Hildebrandt, Sandra-Maria Knetzger, Michael G. Schrauder, Sebastian M. Jud, Alexander Hein, Claudia Rauh, Peter A. Fasching, Matthias W. Beckmann, Falk C. Thiel

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Protein Kinase A-induced tamoxifen resistance is mediated by anchoring protein AKAP13

Cristiane Bentin Toaldo, Xanthippi Alexi, Karin Beelen, Marleen Kok, Michael Hauptmann, Maurice Jansen, Els Berns, Jacques Neefjes, Sabine Linn, Rob Michalides, Wilbert Zwart

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Management of brain metastasis with magnetic resonance imaging and stereotactic irradiation attenuated benefits of prophylactic cranial irradiation in patients with limited-stage small cell lung cancer

Yuichi Ozawa, Minako Omae, Masato Fujii, Takashi Matsui, Masato Kato, Shinya Sagisaka, Kazuhiro Asada, Masato Karayama, Toshihiro Shirai, Kazumasa Yasuda, Yutaro Nakamura, Naoki Inui, Kazunari Yamada, Koshi Yokomura, Takafumi Suda

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

YKL-40 regulated epithelial-mesenchymal transition and migration/invasion enhancement in non-small cell lung cancer

Malvin Jefri, Yi-Ning Huang, Wen-Chien Huang, Chun-San Tai, Wen-Liang Chen

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Essential medicines for breast cancer in low and middle income countries

Y. T. Bazargani, A. de Boer, J. H. M. Schellens, H. G. M. Leufkens, Aukje K. Mantel-Teeuwisse

01.12.2015 | Study protocol | Ausgabe 1/2015 Open Access

Efficacy of a brief manualized intervention Managing Cancer and Living Meaningfully (CALM) adapted to German cancer care settings: study protocol for a randomized controlled trial

Katharina Scheffold, Rebecca Philipp, Dorit Engelmann, Frank Schulz-Kindermann, Christina Rosenberger, Karin Oechsle, Martin Härter, Karl Wegscheider, Florian Lordick, Chris Lo, Sarah Hales, Gary Rodin, Anja Mehnert

01.12.2015 | Study protocol | Ausgabe 1/2015 Open Access

Early salpingectomy (TUbectomy) with delayed oophorectomy to improve quality of life as alternative for risk-reducing salpingo-oophorectomy in BRCA1/2 mutation carriers (TUBA study): a prospective non-randomised multicentre study

Marline G. Harmsen, Marieke Arts-de Jong, Nicoline Hoogerbrugge, Angela H. E. M. Maas, Judith B. Prins, Johan Bulten, Steven Teerenstra, Eddy M. M. Adang, Jurgen M. J. Piek, Helena C van Doorn, Marc van Beurden, Marian J. E. Mourits, Ronald P. Zweemer, Katja N. Gaarenstroom, Brigitte F. M. Slangen, M. Caroline Vos, Luc R. C. W. van Lonkhuijzen, Leon F. A. G. Massuger, Rosella P. M. G. Hermens, Joanne A. de Hullu

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Neutrophil count is associated with survival in localized prostate cancer

Houda Bahig, Daniel Taussky, Guila Delouya, Amal Nadiri, Ariane Gagnon-Jacques, Paule Bodson-Clermont, Denis Soulieres

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Berberine, a natural compound, suppresses Hedgehog signaling pathway activity and cancer growth

Juan Wang, Yuanqiu Peng, Yuan Liu, Jun Yang, Ning Ding, Wenfu Tan

01.12.2015 | Erratum | Ausgabe 1/2015 Open Access

Erratum to: ComOn Coaching: study protocol of a randomized controlled trial to assess the effect of a varied number of coaching sessions on transfer into clinical practice following communication skills training

Marcelo Niglio de Figueiredo, Bärbel Rudolph, Carma L. Bylund, Tanja Goelz, Pia Heußner, Heribert Sattel, Kurt Fritzsche, Alexander Wuensch

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Comparison of the prognosis and recurrence of apparent early-stage ovarian tumors treated with laparoscopy and laparotomy: a meta-analysis of clinical studies

Ying Zhang, Shuying Fan, Yang Xiang, Hua Duan, Li Sun

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Heterogeneity revealed through meta-analysis might link geographical differences with nasopharyngeal carcinoma incidence in Han Chinese populations

Wen-Hui Su, Chi-Cking Chiu, Yin Yao Shugart

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Selective repression of RET proto-oncogene in medullary thyroid carcinoma by a natural alkaloid berberine

Vishnu Muthuraj Kumarasamy, Yoon-Joo Shin, John White, Daekyu Sun

01.12.2015 | Erratum | Ausgabe 1/2015 Open Access

Erratum to: The diagnostic challenge of pulmonary tumour thrombotic microangiopathy as a presentation for metastatic gastric cancer: A case report and review of the literature

Andrew L K Ho, Patryk Szulakowski, Waria H S Mohamid

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

A single-arm phase II trial of combined chemotherapy with S-1, oral leucovorin, and bevacizumab in heavily pre-treated patients with metastatic colorectal cancer

Kazuhisa Yamaguchi, Hiroya Taniguchi, Azusa Komori, Yukiya Narita, Sohei Nitta, Motoo Nomura, Shigenori Kadowaki, Daisuke Takahari, Takashi Ura, Masashi Andoh, Kei Muro, Keita Mori, Yoshinori Igarashi

01.12.2015 | Study protocol | Ausgabe 1/2015 Open Access

PATHOS: a phase II/III trial of risk-stratified, reduced intensity adjuvant treatment in patients undergoing transoral surgery for Human papillomavirus (HPV) positive oropharyngeal cancer

Waheeda Owadally, Chris Hurt, Hayley Timmins, Emma Parsons, Sarah Townsend, Joanne Patterson, Katherine Hutcheson, Ned Powell, Matthew Beasley, Nachi Palaniappan, Max Robinson, Terence M. Jones, Mererid Evans

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Over-expressing Akt in T cells to resist tumor immunosuppression and increase anti-tumor activity

Yanhong Wu, Zhenling Deng, Yishu Tang, Shuren Zhang, Yu-Qian Zhang

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

The transcription factor ERG increases expression of neurotransmitter receptors on prostate cancer cells

Haydn T. Kissick, Seung T. On, Laura K. Dunn, Martin G. Sanda, John M. Asara, Kathryn L. Pellegrini, Jonathan K. Noel, Mohamed S. Arredouani

01.12.2015 | Study protocol | Ausgabe 1/2015 Open Access

Positive family history of colorectal cancer in a general practice setting [FRIDA.Frankfurt]: study protocol of a of a cross-sectional study

Andrea Siebenhofer, Jasper Plath, Maja Taubenroth, Susanne Singer, Marlene Hechtner, Anne Dahlhaus, Sandra Rauck, Sylvia Schulz-Rothe, Insa Koné, Ferdinand M. Gerlach

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Framing overdiagnosis in breast screening: a qualitative study with Australian experts

Lisa M. Parker, Lucie Rychetnik, Stacy Carter

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Cytokine serum levels during post-transplant adverse events in 61 pediatric patients after hematopoietic stem cell transplantation

Michaela Döring, Karin Melanie Cabanillas Stanchi, Markus Mezger, Annika Erbacher, Judith Feucht, Matthias Pfeiffer, Peter Lang, Rupert Handgretinger, Ingo Müller

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Incomplete Dll4/Notch signaling inhibition promotes functional angiogenesis supporting the growth of skin papillomas

Dusan Djokovic, Alexandre Trindade, Joana Gigante, Mario Pinho, Adrian L. Harris, Antonio Duarte

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Gamma tocotrienol targets tyrosine phosphatase SHP2 in mammospheres resulting in cell death through RAS/ERK pathway

Wenyi Gu, Indira Prasadam, Meihua Yu, Fengxia Zhang, Patrick Ling, Yin Xiao, Chengzhong Yu

01.12.2015 | Study protocol | Ausgabe 1/2015 Open Access

The value of completion axillary treatment in sentinel node positive breast cancer patients undergoing a mastectomy: a Dutch randomized controlled multicentre trial (BOOG 2013-07)

L. M. van Roozendaal, J. HW de Wilt, T. van Dalen, J. A. van der Hage, L. JA Strobbe, L. J. Boersma, S. C. Linn, M. BI Lobbes, P. MP Poortmans, V. CG Tjan-Heijnen, K. KBT Van de Vijver, J. de Vries, A. H. Westenberg, A. GH Kessels, M. L. Smidt

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Sulindac, 3,3’-diindolylmethane and curcumin reduce carcinogenesis in the Pirc rat, an Apc-driven model of colon carcinogenesis

Angelo Pietro Femia, Paulo Victoria Soares, Cristina Luceri, Maura Lodovici, Augusto Giannini, Giovanna Caderni

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Patterns of diagnostic imaging and associated radiation exposure among long-term survivors of young adult cancer: a population-based cohort study

Corinne Daly, David R. Urbach, Thérèse A. Stukel, Paul C. Nathan, Wayne Deitel, Lawrence F. Paszat, Andrew S. Wilton, Nancy N. Baxter

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Relationships between cancer pattern, country income and geographical region in Asia

Chirk Jenn Ng, Chin Hai Teo, Nurdiana Abdullah, Wei Phin Tan, Hui Meng Tan

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Patient-derived heavy chain antibody targets cell surface HSP90 on breast tumors

Charan V. Devarakonda, Daniel Kita, Kathryn N. Phoenix, Kevin P. Claffey

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Adjuvant therapy in the treatment of gallbladder cancer: a meta-analysis

Ning Ma, Hui Cheng, Baodong Qin, Renqian Zhong, Bin Wang

01.12.2015 | Case report | Ausgabe 1/2015 Open Access

An infant with hyperalertness, hyperkinesis, and failure to thrive: a rare diencephalic syndrome due to hypothalamic anaplastic astrocytoma

Alessia Stival, Maurizio Lucchesi, Silvia Farina, Anna Maria Buccoliero, Francesca Castiglione, Lorenzo Genitori, Maurizio de Martino, Iacopo Sardi

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Pre-treatment neutrophil-to-lymphocyte ratio is associated with neutrophil and T-cell infiltration and predicts clinical outcome in patients with glioblastoma

Sheng Han, Yang Liu, Qingchang Li, Zhonghua Li, Haipei Hou, Anhua Wu

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Exploring research participation among cancer patients: analysis of a national survey and an in-depth interview study

Louise Mc Grath-Lone, Sophie Day, Claudia Schoenborn, Helen Ward

01.12.2015 | Study protocol | Ausgabe 1/2015 Open Access

Physical Exercise Training versus Relaxation in Allogeneic stem cell transplantation (PETRA Study) – Rationale and design of a randomized trial to evaluate a yearlong exercise intervention on overall survival and side-effects after allogeneic stem cell transplantation

Joachim Wiskemann, Rea Kuehl, Peter Dreger, Gerhard Huber, Nikolaus Kleindienst, Cornelia M. Ulrich, Martin Bohus

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Neoadjuvant administration of Semliki Forest virus expressing interleukin-12 combined with attenuated Salmonella eradicates breast cancer metastasis and achieves long-term survival in immunocompetent mice

M. Gabriela Kramer, Martín Masner, Erkuden Casales, María Moreno, Cristian Smerdou, José A. Chabalgoity

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

A novel somatic mutation in ACD induces telomere lengthening and apoptosis resistance in leukemia cells

Jean-François Spinella, Pauline Cassart, Nicolas Garnier, Philippe Rousseau, Claire Drullion, Chantal Richer, Manon Ouimet, Virginie Saillour, Jasmine Healy, Chantal Autexier, Daniel Sinnett

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

ER, PgR, Ki67, p27Kip1, and histological grade as predictors of pathological complete response in patients with HER2-positive breast cancer receiving neoadjuvant chemotherapy using taxanes followed by fluorouracil, epirubicin, and cyclophosphamide concomitant with trastuzumab

Sasagu Kurozumi, Kenichi Inoue, Hiroyuki Takei, Hiroshi Matsumoto, Masafumi Kurosumi, Jun Horiguchi, Izumi Takeyoshi, Tetsunari Oyama

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

The bifunctional autophagic flux by 2-deoxyglucose to control survival or growth of prostate cancer cells

Jeong Yong Jeon, Seung Won Kim, Ki Cheong Park, Mijin Yun

01.12.2015 | Case report | Ausgabe 1/2015 Open Access

Case report of severe Cushing’s syndrome in medullary thyroid cancer complicated by functional diabetes insipidus, aortic dissection, jejunal intussusception, and paraneoplastic dysautonomia: remission with sorafenib without reduction in cortisol concentration

Muhammad M. Hammami, Najla Duaiji, Ghazi Mutairi, Sabah Aklabi, Nasser Qattan, Mohei El-Din M. Abouzied, Mohamed W. Sous

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Boronic prodrug of 4-hydroxytamoxifen is more efficacious than tamoxifen with enhanced bioavailability independent of CYP2D6 status

Qiu Zhong, Changde Zhang, Qiang Zhang, Lucio Miele, Shilong Zheng, Guangdi Wang

01.12.2015 | Study protocol | Ausgabe 1/2015 Open Access

Study protocol of the TRICOLORE trial: a randomized phase III study of oxaliplatin-based chemotherapy versus combination chemotherapy with S-1, irinotecan, and bevacizumab as first-line therapy for metastatic colorectal cancer

Yoshito Komatsu, Chikashi Ishioka, Ken Shimada, Yasuhide Yamada, Makio Gamoh, Atsushi Sato, Tatsuro Yamaguchi, Satoshi Yuki, Satoshi Morita, Shin Takahashi, Rei Goto, Minoru Kurihara

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Aspirin and P2Y12 inhibition attenuate platelet-induced ovarian cancer cell invasion

Niamh M. Cooke, Cathy D. Spillane, Orla Sheils, John O’Leary, Dermot Kenny

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

DKK1 is a potential novel mediator of cisplatin-refractoriness in non-small cell lung cancer cell lines

Hogir Salim, Dali Zong, Petra Hååg, Metka Novak, Birgitta Mörk, Rolf Lewensohn, Lovisa Lundholm, Kristina Viktorsson

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

A randomized trial of a minimal intervention for sexual concerns after cancer: a comparison of self-help and professionally delivered modalities

Janette Perz, Jane M Ussher, The Australian Cancer and Sexuality Study Team

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

The Deleted in Liver Cancer 1 (Dlc1) tumor suppressor is haploinsufficient for mammary gland development and epithelial cell polarity

Pratima Basak, Rachelle Dillon, Heather Leslie, Afshin Raouf, Michael R. A. Mowat

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

S100A16 promotes differentiation and contributes to a less aggressive tumor phenotype in oral squamous cell carcinoma

Dipak Sapkota, Ove Bruland, Himalaya Parajuli, Tarig A. Osman, Muy-Teck Teh, Anne C. Johannessen, Daniela Elena Costea

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Effects of cytochalasin congeners, microtubule-directed agents, and doxorubicin alone or in combination against human ovarian carcinoma cell lines in vitro

Matthew Trendowski, Timothy D. Christen, Christopher Acquafondata, Thomas P. Fondy

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Optimizing the clinical utility of PCA3 to diagnose prostate cancer in initial prostate biopsy

Jose Rubio-Briones, Angel Borque, Luis M. Esteban, Juan Casanova, Antonio Fernandez-Serra, Luis Rubio, Irene Casanova-Salas, Gerardo Sanz, Jose Domínguez-Escrig, Argimiro Collado, Alvaro Gómez-Ferrer, Inmaculada Iborra, Miguel Ramírez-Backhaus, Francisco Martínez, Ana Calatrava, Jose A. Lopez-Guerrero

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Chemotherapy induces Notch1-dependent MRP1 up-regulation, inhibition of which sensitizes breast cancer cells to chemotherapy

Baek Kim, Sam L. Stephen, Andrew M. Hanby, Kieran Horgan, Sarah L. Perry, Julie Richardson, Elizabeth A. Roundhill, Elizabeth M. A. Valleley, Eldo T. Verghese, Bethany J. Williams, James L. Thorne, Thomas A. Hughes

01.12.2015 | Correspondence | Ausgabe 1/2015 Open Access

An early warning surveillance programme for detecting upper limb deterioration after treatment for breast cancer: A novel technology supported system

Delva Shamley, Karen Robb

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Size is an essential parameter in governing the UVB-protective efficacy of silver nanoparticles in human keratinocytes

Rohan Palanki, Sumit Arora, Nikhil Tyagi, Lilia Rusu, Ajay P. Singh, Srinivas Palanki, James E. Carter, Seema Singh

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Mitogen-activated protein kinase activator with WD40 repeats (MAWD) and MAWD-binding protein induce cell differentiation in gastric cancer

Dongmei Li, Jun Zhang, Yu Xi, Lei Zhang, Wenmei Li, Jiantao Cui, Rui Xing, Yuanmin Pan, Zemin Pan, Feng Li, Youyong Lu

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Coronin 2A (CRN5) expression is associated with colorectal adenoma-adenocarcinoma sequence and oncogenic signalling

Raphael H. Rastetter, Margit Blömacher, Uta Drebber, Marija Marko, Juliane Behrens, Roxana Solga, Sarah Hojeili, Kurchi Bhattacharya, Claudia M. Wunderlich, F. Thomas Wunderlich, Margarete Odenthal, Anja Ziemann, Ludwig Eichinger, Christoph S. Clemen

01.12.2015 | Technical advance | Ausgabe 1/2015 Open Access

An improved sequencing-based strategy to estimate locus-specific DNA methylation

Giulia Brisotto, Alessandra di Gennaro, Valentina Damiano, Michela Armellin, Tiziana Perin, Roberta Maestro, Manuela Santarosa

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Health related quality of life after oesophagectomy: elderly patients refer similar eating and swallowing difficulties than younger patients

Francesco Cavallin, Eleonora Pinto, Luca M. Saadeh, Rita Alfieri, Matteo Cagol, Carlo Castoro, Marco Scarpa

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Secreted frizzled-related protein promotors are hypermethylated in cutaneous squamous carcinoma compared with normal epidermis

Junqin Liang, Xiaojing Kang, Yilinuer Halifu, Xuewen Zeng, Tianbo Jin, Mingxia Zhang, Dong Luo, Yuan Ding, Yunmin Zhou, Buwajier Yakeya, Dilinuer Abudu, Xiongming Pu

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Effect of changes in treatment practice on survival for cervical cancer: results from a population-based study in Manitoba, Canada

Yoon-Jung Kang, Dianne L. O’Connell, Robert Lotocki, Erich V. Kliewer, David E. Goldsbury, Alain A. Demers, Karen Canfell

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Angiogenesis-related protein expression in bevacizumab-treated metastatic colorectal cancer: NOTCH1 detrimental to overall survival

Tadeu Ferreira Paiva Jr., Victor Hugo Fonseca de Jesus, Raul Amorim Marques, Alexandre André Balieiro Anastácio da Costa, Mariana Petaccia de Macedo, Patricia Maria Peresi, Aline Damascena, Benedito Mauro Rossi, Maria Dirlei Begnami, Vladmir Cláudio Cordeiro de Lima

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

Expression profiling of O6 methylguanine-DNA-methyl transferase in prolactinomas: a correlative study of promoter m