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Journal of Neural Transmission

Erschienen in:

01.04.2009 | Basic Neurosciences, Genetics and Immunology - Original Article

Lamotrigine and valproic acid have different effects on motorcortical neuronal excitability

verfasst von: Xingbao Li, Raffaella Ricci, Charles H. Large, Berry Anderson, Ziad Nahas, Mark S. George

Erschienen in: Journal of Neural Transmission | Ausgabe 4/2009

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Abstract

To investigate different cortical effects of lamotrigine and valproic acid, 30 paid healthy adult men were given, in a randomized/blinded fashion on three separate days (separated by a week), either a single dose of lamotrigine 325 mg, or a single dose of valproic acid 1,250 mg, or placebo. Resting motor threshold (RMT), cortical silent period (CSP) and motor evoked potential recruitment curves (RC) were assessed at baseline and 3 h after administration of each medication (or placebo). Lamotrigine caused a significant increase (63.32 vs. 69.25) in the RMT, compared with an insignificant increase following valproic acid (62.50 vs. 63.35), and a decrease (62.60 vs. 62.36) following placebo (F _2,26 = 18.58, P < 0.0001). No significant difference in CSP was found between placebo and drugs (F _2,26 = 0.119, P > 0.05). RCs were significantly suppressed by lamotrigine (t = 2.07, P < 0.05) and enhanced by valproic acid (t = 2.39, P < 0.05). Lamotrigine and valproic acid have different effects on cortical neuronal excitability as demonstrated by TMS.

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Titel: Lamotrigine and valproic acid have different effects on motorcortical neuronal excitability
verfasst von: Xingbao Li
Raffaella Ricci
Charles H. Large
Berry Anderson
Ziad Nahas
Mark S. George
Publikationsdatum: 01.04.2009
Verlag: Springer Vienna
Erschienen in: Journal of Neural Transmission / Ausgabe 4/2009
Print ISSN: 0300-9564
Elektronische ISSN: 1435-1463
DOI: https://doi.org/10.1007/s00702-009-0195-z

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