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Lasers in Medical Science

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01.01.2015 | Original Article

Laser irradiation of ferrous particles for hyperthermia as cancer therapy, a theoretical study

verfasst von: Jigar M. Patel, Cahit A. Evrensel, Alan Fuchs, Joko Sutrisno

Erschienen in: Lasers in Medical Science | Ausgabe 1/2015

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Abstract

Our recent in vivo animal studies showed the feasibility of using micron sized iron particles to induce physical damage to breast cancer tumors and thereby triggering a localized immune response to help fight the cancer. Combining a hyperthermic treatment with this ongoing study may enhance the immune response. As a result, a novel treatment of inducing hyperthermia using iron particles excited by a continuous wave near-infrared laser was analyzed. In this theoretical study, Mie scattering calculations were first conducted to determine the absorption and scattering efficiencies of the suspended drug coated particles. The resulting heat transfer between the particles and the surrounding tumor and the healthy tissue was modeled using Pennes’ Bioheat equation. Predicted temperature changes were satisfactory for inducing hyperthermia (42^∘C), thermally triggering drug release, and even thermal ablation (55^∘C).

𝜖″(ω) has an additional term of conductance divided by the field frequency, σ/ω, since the material is a metal.

It is meaningful in the range where the wavelength of oscillation is much greater than the atomic dimension of the material.

Andrȧ W, d’Ambly C, Hergt R, Hilger I, Kaiser WA (1999) Temperature distribution as function of time around a small spherical heat source of local magnetic hyperthermia. J Magn Magn Mater 194:197–203CrossRef

Atkinson WJ, Brezovich IA, Chakraborty DP (1984) Usable frequencies in hyperthermia with thermal seeds. IEEE Trans BME Biomed Eng 31(1):70–75CrossRef

Bagaria HG, Johnson DT (2005) Transient solution to the bioheat equation and optimization for magnetic fluid hyperthermia treatment. Int J Hyperth 21(1):57–75. doi:10.1080/02656730410001726956 CrossRef

Bohren CF, Huffman DR (1983) Absorption and scattering of light by small particles. Wiley

Bouchlaka MN, Sckisel GD, Wilkins D, Maverakis E, Monjazeb AM, Fung M, Welniak L, Redelman D, Fuchs A, Evrensel CA, Murphy WM (2012) Mechanical disruption of tumors by iron particles and magnetic field application results in increased anti-tumor immune responses. PLoS ONE 7 (10). doi:10.1371/journal.pone.0048049 PubMedCentralPubMed

Bray F, Jemal A, Grey N, Ferlay J, Forman D (2012) Global cancer transitions according to the Human Development Index (2008–2030): a population-based study. The Lancet Oncology. doi:10.1016/S1470-2045(12)70211-5. in Press

Byrnes KR, Waynant RW, Ilev IK, Wu X, Barna L, Smith K, Heckert R, Gerst H, Anders JJ (2005) Light promotes regeneration and functional recovery and alters the immune response after spinal cord injury. Lasers Surg Med 36(3):171–185PubMedCrossRef

Cerussi A, Shah N, Tromberg B, Hsiang D, Butler J, Durkin A (2006) Electromagnetic scattering by magnetic spheres. J Biomed Opt 11 (4)

Cippitelli M, Fionda C, Di Bona D, Piccoli M, Frati L, Santoni A (2005) Hyperthermia enhances CD95-ligand gene expression in T lymphocytes. J Immunol 174(1):223–232PubMedCrossRef

10.

Cubeddu R, Pifferi A, Taroni P, Torricelli A, Valentini G (1999) Noninvasive absorption and scattering spectroscopy of bulk diffusive media: An application to the optical characterization of human breast. Appl Phys Lett 74(6):874–876CrossRef

11.

Deng ZS, Liu J (2001) Blood perfusion-based model for characterizing the temperature fluctuation in living tissues. Physica A: Statistical Mechanics and its Applications, vol 300

12.

DeRosa ME, DeRosa RL, Noni LM, Hendrick ES (2007) Phase separation of poly(N-isopropylacrylamide) solutions and gels using a near infrared fiber laser. J Appl Polym Sci 105(4):2083–2090CrossRef

13.

Du H (2004) Mie-Scattering Calculation. Appl Opt 43(9):1951–1956PubMedCrossRef

14.

Durduran T, Choe R, Culver J, Zubkow L, Holboke M, Giammarco J, Chance B, Yodh A (2002) Bulk optical properties of healthy female breast tissue. Phys Med Biol 47:2847–2861PubMedCrossRef

15.

Erickson TA, Tunnell JW (2007) Gold nanoshells in biomedical applications. Wiley-VCH Verlag GmbH & Co. KGaA

16.

Evrensel C, Fuchs A, Gordaninejad F , Patel J, Sutrisno J , Nation C, Cook C , Rosen A, Bouchlaka M, Murphy W (2011) Immunotherapy with magnetorheologic fluids. Era of hope

17.

Hapke B (2005) Theory of reflectance and emittance spectroscopy, 1st edn. Cambridge University Press

18.

Hergt R, Dutz S, Mu̇ller R, Zeisberger M (2006) Magnetic particle hyperthermia: nanoparticle magnetism and materials development for cancer therapy. J Phys Condens Matter 18(38):S2919CrossRef

19.

Hilger I, Hergt R, Kaiser WA (2005) Towards breast cancer treatment by magnetic heating. J Magn Magn Mater 293(1):314–319CrossRef

20.

Hirsch L, West J, Stafford R, Bankson J, Sershen S, Price R, Hazle J, Halas N (2003) Nanoshell-mediated near-infrared thermal therapy of tumors under magnetic resonance guidance. Proc Natl Acad Sci U S A 100(23):13, 549–13, 554CrossRef

21.

Hulst HVD (1957) Light Scattering by Small Particles. Wiley

22.

Jain PK, Lee KS, El-Sayed IH, El-Sayed MA (2006) Calculated absorption and scattering properties of gold nanoparticles of different size, shape, and composition: applications in biological imaging and biomedicine. J Phys Chem B 110(14):7238–7248PubMedCrossRef

23.

Keblinski P, Cahill DG, Bodapati A, Sullivan CR, Taton T (2006) Limits of localized heating by electromagnetically excited nanoparticles. J Appl Phys: 100

24.

Kerker M (1969) The Scattering of Light and other electromagnetic radiation. Academic Press. Inc

25.

Kittel C (2004) Introduction to solid state physics, 8th edn. Wiley

26.

Landau L, Lifshitz E , Pitaevskiĭ L (1984) Electrodynamics of continuous media, vol 8, 2nd edn. Pergamon Press

27.

Letfullin RR, Joenathan C, George TF, Zharov VP (2006) Laser-induced explosion of gold nanoparticles: potential role for nanophotothermolysis of cancer. Nanomedicine 1(4):473– 480PubMedCrossRef

28.

Ordal MA, Long LL, Bell RJ, Bell SE, Bell RR, R W Alexander J, Ward CA (1983) Optical properties of the metals Al, Co, Cu, Au, Fe, Pb, Ni, Pd, Pt, Ag, Ti, and W in the infrared and far infrared. Appl Opt 22(7):1099–1119PubMedCrossRef

29.

Pitsillides CM, Joe EK, Wei X, Anderson RR, Lin CP (2003) Selective cell targeting with light-absorbing microparticles and nanoparticles. Biophys J 84(6):4023–4032. doi:10.1016/S0006-3495(03)75128-5 PubMedCentralPubMedCrossRef

30.

Qin Z, Bischof JC (2012) Thermophysical and biological responses of gold nanoparticle laser heating. Chem Soc Rev 41:1191–1217PubMedCrossRef

31.

Schueller G, Stift A, Friedl J, Dubsky P, Bachleitner-Hofmann T, Benkoe T, Jakesz R, Gnant M (2003) Hyperthermia improves cellular immune response to human hepatocellular carcinoma subsequent to co-culture with tumor lysate pulsed dendritic cells. Int J Oncol 22(6):1397–1402PubMed

32.

Shah N, Cerussi A, Eker C, Espinoza J, Butler J, Fishkin J, Hornung R, Tromberg B (2001) Noninvasive functional optical spectroscopy of human breast tissue. Proc Natl Acad Sci 98(8):4420–4425PubMedCentralPubMedCrossRef

33.

Srinivasan S, Pogue BW, Jiang S, Dehghani H, Kogel C, Soho S, Gibson J, Tosteson T, Poplack S, Paulsen K (2003) Interpreting hemoglobin and water concentration, oxygen saturation, and scattering measured in vivo by near-infrared breat tomography. Proc Natl Acad Sci U S A 100(21):12, 349–12, 354CrossRef

34.

Stratton JA (1941) Electromagnetic Theory. McGraw-Hill Book Company. Inc

35.

Tamer U, Gündoğdu Y, Boyaci IH, Pekmez K (2010) Synthesis of magnetic core-shell Fe₃O₄-Au nanoparticle for biomolecule immobilization and detection. J Nanopart Res 12:1187–1196CrossRef

36.

Tromberg B, Shah N, Lanning R, Cerussi A, Espinoza J, Pham T, Svaasand L, Butler J (2000) Non-Invasive in vivo characterizatoin of breast tumors using photon migration spectroscopy. Neoplasia 2(1-2):26–40PubMedCentralPubMedCrossRef

37.

Weissleder R (2001) A clearer vision for in vivo imaging. Nat Biotechnol: 19

38.

Welch AJ, van Gemert MJ (2011) Optical-thermal response of laser-irradiated tissue, 2nd edn. Springer

39.

Welch AJ, Torres J, Cheong WF (1989) Laser physics and laser-tissue interaction. Tex Heart Inst J 16(3):141–149PubMedCentralPubMed

40.

Zhang HG, Mehta K, Cohen P, Guha C (2008) Hyperthermia on immune regulation: A temperature’s story. Cancer Lett 271(2):191–204PubMedCrossRef

41.

Zharov VP, Letfullin RR, Galitovskaya EN (2005) Microbubbles-overlapping mode for laser killing of cancer cells with absorbing nanoparticle clusters. J Phys D Appl Phys 38:2571–2581CrossRef

Titel: Laser irradiation of ferrous particles for hyperthermia as cancer therapy, a theoretical study
verfasst von: Jigar M. Patel
Cahit A. Evrensel
Alan Fuchs
Joko Sutrisno
Publikationsdatum: 01.01.2015
Verlag: Springer London
Erschienen in: Lasers in Medical Science / Ausgabe 1/2015
Print ISSN: 0268-8921
Elektronische ISSN: 1435-604X
DOI: https://doi.org/10.1007/s10103-014-1618-0

Springer Medizin

Abstract

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