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Erschienen in: Calcified Tissue International 3/2014

01.09.2014 | Case Reports

Late-Onset Subcutaneous Scalp Calcifications in a Patient with Pseudo-Pseudohypoparathyroidism

verfasst von: Laura Ramos, María Piedra, Elena Sánchez, José A. Amado

Erschienen in: Calcified Tissue International | Ausgabe 3/2014

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Abstract

Ectopic calcifications and even bone formation have been linked to GNAS gene mutations. A 51-year-old Caucasian female had been diagnosed of pseudo-pseudohypoparathyroidism (PPHP) in 1989. She has always had normal serum parathyroid hormone, calcium, and phosphorus levels. A non-contrast computed tomography of the head was done in 2013 and it showed finely speckled subcutaneous calcifications in the high convexity of the head. Cutaneous exploration did not show any abnormality. We herein report an unusual case of late-onset scalp calcifications in a patient with PPHP.
Literatur
1.
Zurück zum Zitat Adegbite NS, Xu M, Kaplan FS, Shore EM, Pignolo RJ (2008) Diagnostic and mutational spectrum of progressive osseous heteroplasia (POH) and other forms of GNAS-based heterotopic ossification. Am J Med Genet Part A 146A:1788–1796PubMedCentralPubMedCrossRef Adegbite NS, Xu M, Kaplan FS, Shore EM, Pignolo RJ (2008) Diagnostic and mutational spectrum of progressive osseous heteroplasia (POH) and other forms of GNAS-based heterotopic ossification. Am J Med Genet Part A 146A:1788–1796PubMedCentralPubMedCrossRef
2.
Zurück zum Zitat Schimmel RJ, Pasmans SG, Xu M, Stadhouders-Keet SA, Shore EM, Kaplan FS, Wulffraat NM (2010) GNAS-associated disorders of cutaneous ossification: two different clinical presentations. Bone 46:868–872PubMedCentralPubMedCrossRef Schimmel RJ, Pasmans SG, Xu M, Stadhouders-Keet SA, Shore EM, Kaplan FS, Wulffraat NM (2010) GNAS-associated disorders of cutaneous ossification: two different clinical presentations. Bone 46:868–872PubMedCentralPubMedCrossRef
3.
Zurück zum Zitat Jeong KH, Lew BL, Sim WY (2009) Osteoma cutis as the presenting feature of albright hereditary osteodystrophy associated with pseudopseudohypoparathyroidism. Ann Dermatol 21:154–158PubMedCentralPubMedCrossRef Jeong KH, Lew BL, Sim WY (2009) Osteoma cutis as the presenting feature of albright hereditary osteodystrophy associated with pseudopseudohypoparathyroidism. Ann Dermatol 21:154–158PubMedCentralPubMedCrossRef
4.
Zurück zum Zitat Eyre WG, Reed WB (1971) Albright`s hereditary osteodystrophy with cutaneous bone formation. Arch Dermatol 104:634–642PubMedCrossRef Eyre WG, Reed WB (1971) Albright`s hereditary osteodystrophy with cutaneous bone formation. Arch Dermatol 104:634–642PubMedCrossRef
5.
Zurück zum Zitat Lietman SA, Ding C, Cooke DW, Levine MA (2005) Reduction in Gs alpha induces osteogenic differentiation in human mesenchymal stem cells. Clin Orthop Relat Res 434:231–238PubMedCrossRef Lietman SA, Ding C, Cooke DW, Levine MA (2005) Reduction in Gs alpha induces osteogenic differentiation in human mesenchymal stem cells. Clin Orthop Relat Res 434:231–238PubMedCrossRef
6.
Zurück zum Zitat Oikarinen A, Tuomi ML, Kallionen M, Sandberg M, Väänänen K (1992) A study of bone formation in osteoma cutis employing biochemical, histochemical and in situ hybridization techniques. Acta Derm Venearol 72:172–174 Oikarinen A, Tuomi ML, Kallionen M, Sandberg M, Väänänen K (1992) A study of bone formation in osteoma cutis employing biochemical, histochemical and in situ hybridization techniques. Acta Derm Venearol 72:172–174
7.
Zurück zum Zitat Boivin G, Walzer C, Baud CA (1987) Ultrastructural study of the long-term development of two experimental cutaneous calcinoses (topical calciphylaxis and topical calcergy) in the rat. Cell Tissue Res 247:525–532PubMedCrossRef Boivin G, Walzer C, Baud CA (1987) Ultrastructural study of the long-term development of two experimental cutaneous calcinoses (topical calciphylaxis and topical calcergy) in the rat. Cell Tissue Res 247:525–532PubMedCrossRef
8.
Zurück zum Zitat Takaoka K, Nakahara H, Yoshikawa H, Masuhara K, Tsuda T, Ono K (1988) Ectopic bone induction on and in porous hydroxyapatite combined with collagen and bone morphogenetic protein. Clin Orthop Relat Res 234:250–254PubMed Takaoka K, Nakahara H, Yoshikawa H, Masuhara K, Tsuda T, Ono K (1988) Ectopic bone induction on and in porous hydroxyapatite combined with collagen and bone morphogenetic protein. Clin Orthop Relat Res 234:250–254PubMed
Metadaten
Titel
Late-Onset Subcutaneous Scalp Calcifications in a Patient with Pseudo-Pseudohypoparathyroidism
verfasst von
Laura Ramos
María Piedra
Elena Sánchez
José A. Amado
Publikationsdatum
01.09.2014
Verlag
Springer US
Erschienen in
Calcified Tissue International / Ausgabe 3/2014
Print ISSN: 0171-967X
Elektronische ISSN: 1432-0827
DOI
https://doi.org/10.1007/s00223-014-9890-3

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