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01.02.2015 | Original Article

Levels of adiponectin and leptin at onset of type 1 diabetes have changed over time in children and adolescents

verfasst von: Narges Safai, Stefanie Eising, David Michael Hougaard, Henrik Bindesbøl Mortensen, Kristin Skogstrand, Flemming Pociot, Jesper Johannesen, Jannet Svensson

Erschienen in: Acta Diabetologica | Ausgabe 1/2015

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Abstract

Adiponectin and leptin are proteins secreted by the adipose tissue and have an influence on insulin sensitivity and on inflammatory markers. Altered levels could play a part in the pathogenesis of type 1 diabetes mellitus. We determined adiponectin and leptin levels over a nine-year period in children with type 1 diabetes mellitus (T1D) in relation to the increasing incidence of T1D, and studied the impact of patient status, age, gender and body mass index (BMI). Data were derived from a population-based registry of diabetic children (DanDiabKids) from 1997 to 2005. Children with newly diagnosed T1D (n = 482) were included, and healthy siblings (n = 479) were chosen as a control group. Leptin levels were significantly higher in recent years (in both patients and siblings), whereas for adiponectin, the levels were lower in recent years in the patient group. Leptin levels were lower in children with T1D (RR 0.74, p = 0.003) and in males (RR 0.52, p < 0.001) and increasing with age in both groups. For adiponectin, there was a negative association between level and age in patients. Both adipokines showed a significant correlation with BMI and lower levels in children with blood samples taken within the first 2 days after initiation of insulin treatment. There has been a change in leptin and adiponectin levels in children with or without T1D from 1997 to 2005. This is not explained by changes in BMI and may reflect changes in other factors like diet or physical activity.

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Titel: Levels of adiponectin and leptin at onset of type 1 diabetes have changed over time in children and adolescents
verfasst von: Narges Safai
Stefanie Eising
David Michael Hougaard
Henrik Bindesbøl Mortensen
Kristin Skogstrand
Flemming Pociot
Jesper Johannesen
Jannet Svensson
Publikationsdatum: 01.02.2015
Verlag: Springer Milan
Erschienen in: Acta Diabetologica / Ausgabe 1/2015
Print ISSN: 0940-5429
Elektronische ISSN: 1432-5233
DOI: https://doi.org/10.1007/s00592-014-0630-y

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