Background
Methods
Sources of data
Socioeconomic position across the life course
Outcome measures
Statistical analysis
Socio-economic position in: | ||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Childhood(Parental possession of a watch, sewing machine, and bicycle) | Early Adulthood (Education*) | Late Adulthood (Occupation) | Current (Household Income per Head) | |||||||||||||
No. | 0 items | 1+ items | Unknown |
p † | Low | High |
p † | Manual | Non-manual | Unknown |
p † | Low | High | Unknown |
p † | |
Women
| ||||||||||||||||
Number of participants | 7445 | 4084 | 3123 | 238 | 3057 | 4386 | 5225 | 1211 | 1009 | 3025 | 3141 | 1279 | ||||
Mean (SD)
| ||||||||||||||||
White blood cells (109/L) | 7445 | 6.38(1.5) | 6.13(1.5) | 6.36(1.4) | <0.001 | 6.52(1.6) | 6.10(1.5) | <0.001 | 6.33(1.5) | 6.04(1.4) | 6.25(1.5) | <0.001 | 6.38(1.6) | 6.12(1.5) | 6.41(1.6) | <0.001 |
Granulocytes (109/L) | 7445 | 3.79(1.2) | 3.62(1.2) | 3.71(1.1) | <0.001 | 3.89(1.2) | 3.60(1.1) | <0.001 | 3.76(1.2) | 3.53(1.1) | 3.71(1.2) | <0.001 | 3.79(1.2) | 3.60(1.1) | 3.84(1.2) | <0.001 |
Lymphocytes (109/L) | 7445 | 2.19(0.6) | 2.15(0.6) | 2.26(0.6) | <0.001 | 2.22(0.6) | 2.14(0.6) | <0.001 | 2.18(0.6) | 2.15(0.6) | 2.18(0.6) | 0.227 | 2.20(0.6) | 2.16(0.6) | 2.16(0.6) | 0.008 |
Leg length (cm) | 7430 | 69.7(3.8) | 69.8(3.6) | 69.8(4.3) | 0.393 | 69.6(3.8) | 69.8(3.7) | 0.008 | 69.7(3.7) | 69.9(3.6) | 69.6(3.8) | 0.202 | 69.6(3.8) | 69.8(3.6) | 69.6(3.8) | 0.099 |
Sitting height (cm) | 7431 | 83.7(3.6) | 85.1(3.1) | 84.1(3.7) | <0.001 | 83.1(3.6) | 85.1(3.1) | <0.001 | 84.0(3.5) | 85.0(3.3) | 84.6(3.3) | <0.001 | 83.9(3.5) | 85.0(3.2) | 83.5(3.7) | <0.001 |
Row%
| ||||||||||||||||
Age group (years)
| ||||||||||||||||
50-54
| 2644 | 36.0 | 60.7 | 3.3 | 17.9 | 82.1 | 65.0 | 18.5 | 16.5 | 36.0 | 53.0 | 11.1 | ||||
55-59
| 1892 | 52.7 | 44.5 | 2.7 | 39.1 | 60.9 | 69.8 | 17.2 | 12.9 | 39.0 | 44.2 | 16.8 | ||||
60-64
| 1133 | 64.9 | 32.7 | 2.5 | 51.5 | 48.5 | 73.8 | 14.7 | 11.6 | 46.5 | 34.6 | 18.9 | ||||
65-69
| 833 | 74.5 | 21.5 | 4.0 | 63.5 | 36.4 | 76.1 | 13.8 | 10.1 | 46.2 | 29.7 | 24.1 | ||||
70-74
| 621 | 82.8 | 13.4 | 3.9 | 75.7 | 24.3 | 75.0 | 13.7 | 11.3 | 44.8 | 28.3 | 26.9 | ||||
75-79
| 228 | 82.0 | 14.5 | 3.5 | 81.1 | 18.4 | 75.9 | 10.5 | 13.6 | 49.1 | 25.0 | 25.9 | ||||
80+
| 94 | 80.9 | 12.8 | 6.4 | <0.001 | 81.9 | 18.1 | <0.001 | 81.9 | 5.3 | 12.8 | <0.001 | 37.2 | 34.0 | 28.7 | <0.001 |
Alcohol use
| ||||||||||||||||
Never | 3981 | 57.9 | 39.1 | 3.1 | 45.9 | 54.1 | 71.7 | 15.2 | 13.1 | 43.8 | 37.8 | 18.4 | ||||
<1/week | 2811 | 49.8 | 47.1 | 3.2 | 33.8 | 66.2 | 67.4 | 18.1 | 14.5 | 36.7 | 48.4 | 14.9 | ||||
1-4/week | 162 | 53.1 | 40.7 | 6.2 | 35.2 | 64.8 | 72.8 | 16.7 | 10.5 | 35.8 | 47.5 | 16.7 | ||||
5+/week | 126 | 63.5 | 33.3 | 3.2 | 43.7 | 56.3 | 70.6 | 13.5 | 15.9 | 34.1 | 46.8 | 19.0 | ||||
Ex-drinker | 196 | 62.8 | 34.7 | 2.6 | <0.001 | 50.5 | 49.5 | <0.001 | 78.1 | 11.2 | 10.7 | 0.001 | 44.4 | 35.2 | 20.4 | <0.001 |
Unknown
| 169 | 54.4 | 40.8 | 4.7 | 41.4 | 57.4 | 68.6 | 17.8 | 13.6 | 36.1 | 43.2 | 20.7 | ||||
Smoking status
| ||||||||||||||||
Never
| 7192 | 54.5 | 42.4 | 3.1 | 40.1 | 59.9 | 70.0 | 16.4 | 13.5 | 40.4 | 42.5 | 17.1 | ||||
Ex-smoker
| 95 | 76.8 | 18.9 | 4.2 | 87.4 | 12.6 | 77.9 | 6.3 | 15.8 | 46.3 | 27.4 | 26.3 | ||||
Current
| 106 | 63.2 | 28.3 | 8.5 | <0.001 | 65.1 | 34.9 | <0.001 | 79.2 | 12.3 | 8.5 | 0.013 | 55.7 | 27.4 | 17.0 | <0.001 |
Unknown
| 52 | 48.1 | 46.2 | 5.8 | 38.5 | 57.7 | 61.5 | 17.3 | 21.2 | 34.6 | 51.9 | 13.5 | ||||
Physical activity
| ||||||||||||||||
Inactive
| 626 | 55.4 | 40.7 | 3.8 | 42.8 | 56.9 | 71.4 | 15.8 | 12.8 | 40.3 | 38.0 | 21.7 | ||||
Minimally active
| 1848 | 54.9 | 42.0 | 3.1 | 41.5 | 58.5 | 70.1 | 17.4 | 12.6 | 41.7 | 41.3 | 16.9 | ||||
HEPA active
$
| 4971 | 54.8 | 42.1 | 3.2 | 0.877 | 40.7 | 59.3 | 0.520 | 70.1 | 15.9 | 14.0 | 0.450 | 40.3 | 43.0 | 16.7 | 0.249 |
Socio-economic position in
| ||||||||||||||||
Childhood(Parental possession of a watch, sewing machine, and bicycle
|
Early Adulthood (Education*)
|
Late Adulthood (Occupation)
|
Current (Household Income per Head)
| |||||||||||||
No.
|
0 items
|
1+ items
|
Unknown
|
p
†
|
Low
|
High
|
p
†
|
Manual
|
Non-manual
|
Unknown
|
p
†
|
Low
|
High
|
Unknown
|
p
†
| |
Men
| ||||||||||||||||
Number of participants | 2536 | 1664 | 812 | 60 | 730 | 1803 | 1581 | 791 | 164 | 1131 | 1035 | 370 | ||||
Mean (SD)
| ||||||||||||||||
White blood cells (109/L) | 2536 | 6.85(1.7) | 6.86(1.7) | 6.74(1.5) | 0.878 | 7.01(1.7) | 6.79(1.7) | 0.010 | 6.87(1.7) | 6.75(1.7) | 7.15(1.9) | 0.021 | 6.93(1.7) | 6.73(1.7) | 6.95(1.7) | 0.012 |
Granulocytes (109/L) | 2536 | 4.21(1.4) | 4.14(1.4) | 4.17(1.1) | 0.439 | 4.38(1.4) | 4.11(1.3) | <0.001 | 4.21(1.4) | 4.10(1.3) | 4.40(1.6) | 0.018 | 4.27(1.4) | 4.07(1.3) | 4.27(1.4) | 0.002 |
Lymphocytes (109/L) | 2536 | 2.14(0.6) | 2.23(0.7) | 2.05(0.5) | 0.002 | 2.10(0.6) | 2.19(0.7) | 0.006 | 2.16(0.7) | 2.17(0.6) | 2.23(0.6) | 0.389 | 2.15(0.7) | 2.18(0.6) | 2.18(0.7) | 0.619 |
Leg length (cm) | 2519 | 75.2(3.8) | 75.7(4.2) | 75.3(3.7) | 0.005 | 74.6(3.7) | 75.6(4.0) | <0.001 | 75.2(3.9) | 75.6(4.0) | 75.6(3.9) | 0.020 | 75.1(4.0) | 75.7(3.8) | 75.1(4.0) | 0.003 |
Sitting height (cm) | 2520 | 88.6(3.6) | 89.8(3.4) | 88.7(3.7) | <0.001 | 87.6(3.5) | 89.6(3.4) | <0.001 | 88.8(3.6) | 89.3(3.4) | 89.7(4.0) | <0.001 | 88.5(3.5) | 89.7(3.4) | 88.6(3.8) | <0.001 |
Row%
| ||||||||||||||||
Age group (years)
| ||||||||||||||||
50-54
| 346 | 41.3 | 56.6 | 2.0 | 11.3 | 88.7 | 68.8 | 21.4 | 9.8 | 43.9 | 42.8 | 13.3 | ||||
55-59
| 568 | 57.0 | 41.0 | 1.9 | 23.6 | 76.4 | 67.3 | 25.4 | 7.4 | 44.9 | 43.0 | 12.1 | ||||
60-64
| 599 | 65.4 | 32.2 | 2.3 | 25.2 | 74.6 | 61.3 | 32.9 | 5.8 | 37.4 | 47.9 | 14.7 | ||||
65-69
| 470 | 76.0 | 22.3 | 1.7 | 30.6 | 69.1 | 56.8 | 38.5 | 4.7 | 48.5 | 37.0 | 14.5 | ||||
70-74
| 339 | 82.3 | 15.3 | 2.4 | 44.5 | 55.5 | 58.7 | 36.3 | 5.0 | 48.7 | 32.2 | 19.2 | ||||
75-79
| 156 | 78.2 | 16.0 | 5.8 | 51.3 | 48.1 | 60.9 | 32.1 | 7.1 | 48.1 | 35.9 | 16.0 | ||||
80+
| 58 | 81.0 | 13.8 | 5.2 | <0.001 | 53.4 | 46.6 | <0.001 | 56.9 | 37.9 | 5.2 | <0.001 | 55.2 | 29.3 | 15.5 | <0.001 |
Alcohol use
| ||||||||||||||||
Never | 880 | 68.3 | 29.9 | 1.8 | 30.1 | 69.9 | 61.0 | 32.0 | 6.9 | 48.1 | 36.8 | 15.1 | ||||
<1/week | 1068 | 63.2 | 34.7 | 2.1 | 24.4 | 75.6 | 61.5 | 32.0 | 6.5 | 41.5 | 44.4 | 14.1 | ||||
1-4/week | 176 | 62.5 | 34.7 | 2.8 | 25.6 | 74.4 | 67.6 | 28.4 | 4.0 | 46.0 | 44.9 | 9.1 | ||||
5+/week | 271 | 65.7 | 32.5 | 1.8 | 39.9 | 60.1 | 66.4 | 28.8 | 4.8 | 43.9 | 39.9 | 16.2 | ||||
Ex-drinker | 93 | 71.0 | 21.5 | 7.5 | 0.046 | 37.6 | 62.4 | <0.001 | 67.7 | 24.7 | 7.5 | 0.323 | 49.5 | 34.4 | 16.1 | 0.011 |
Unknown
| 48 | 70.8 | 18.8 | 10.4 | 33.3 | 60.4 | 52.1 | 33.3 | 14.6 | 39.6 | 37.5 | 22.9 | ||||
Smoking status
| ||||||||||||||||
Never
| 940 | 63.8 | 34.3 | 1.9 | 20.3 | 79.7 | 58.3 | 35.3 | 6.4 | 41.0 | 45.5 | 13.5 | ||||
Ex-smoker
| 675 | 69.0 | 28.1 | 2.8 | 33.5 | 66.5 | 62.2 | 31.3 | 6.5 | 46.2 | 40.4 | 13.3 | ||||
Current
| 900 | 65.1 | 32.9 | 2.0 | 0.039 | 34.3 | 65.7 | <0.001 | 66.8 | 27.0 | 6.2 | <0.001 | 47.6 | 36.2 | 16.2 | <0.001 |
Unknown
| 21 | 57.1 | 19.0 | 23.8 | 19.0 | 66.7 | 57.1 | 23.8 | 19.0 | 28.6 | 38.1 | 33.3 | ||||
Physical activity
| ||||||||||||||||
Inactive
| 223 | 65.9 | 31.4 | 2.7 | 31.8 | 66.8 | 68.6 | 26.0 | 5.4 | 48.4 | 30.9 | 20.6 | ||||
Minimally active
| 866 | 61.1 | 36.4 | 2.5 | 29.1 | 70.9 | 58.8 | 33.9 | 7.3 | 44.3 | 40.9 | 14.8 | ||||
HEPA active
$
| 1447 | 68.3 | 29.5 | 2.2 | 0.002 | 28.1 | 71.9 | 0.438 | 63.5 | 30.3 | 6.2 | 0.021 | 44.2 | 42.3 | 13.5 | 0.046 |
Results
White Blood Cell Count (109/L) | Granulocyte Cell Count (109/L) | |||||
---|---|---|---|---|---|---|
Δ | 95% CI | AIC | Δ | 95% CI | AIC | |
Men and Women
| ||||||
Critical period Modelb
| ||||||
Childhood
|
-0.14
|
(-0.20, -0.07)
| 8995 |
-0.10
|
(-0.15, -0.04)
| 4095 |
Early Adult
|
-0.35
|
(-0.42, -0.29)
| 8909 |
-0.26
|
(-0.31, -0.21)
| 4018 |
Late Adult
|
-0.21
|
(-0.29, -0.13)
| 8980 |
-0.17
|
(-0.23, -0.11)
| 4074 |
Current
|
-0.22
|
(-0.29, -0.15)
| 8965 |
-0.16
|
(-0.22, -0.11)
| 4064 |
Accumulation Model
c
| 8905 | 4012 | ||||
0
| 0 | 0 | ||||
1
|
-0.19
|
(-0.29, -0.09)
|
-0.14
|
(-0.22, -0.06)
| ||
2
|
-0.32
|
(-0.42, -0.22)
|
-0.23
|
(-0.31, -0.16)
| ||
3
|
-0.48
|
(-0.58, -0.38)
|
-0.35
|
(-0.43, -0.27)
| ||
4
|
-0.51
|
(-0.65, -0.38)
|
-0.40
|
(-0.50, -0.29)
| ||
Sensitive Periods Modeld
|
8892
|
4000
| ||||
Childhood
| -0.06 | (-0.13, 0.01) | -0.03 | (-0.09, 0.02) | ||
Early Adult
|
-0.28
|
(-0.36, -0.20)
|
-0.20
|
(-0.26, -0.14)
| ||
Late Adult
| -0.08 | (-0.17, 0.002) |
-0.08
|
(-0.14, -0.01)
| ||
Current
|
-0.12
|
(-0.19, -0.05)
|
-0.09
|
(-0.15, -0.04)
| ||
Fully Saturated Modele
| 8905 | 4015 |
Women (n = 7,445) | Men (n = 2,536) | |||||
---|---|---|---|---|---|---|
Δ | 95% CI | AIC | Δ | 95% CI | AIC | |
Critical period Modelb
| ||||||
Childhood
|
-0.04
|
(-0.07, -0.01)
| -7874 | 0.03 | (-0.03, 0.08) | -2277 |
Early Adult
|
-0.08
|
(-0.11, -0.05)
|
-7894
| 0.03 | (-0.02, 0.09) | -2277 |
Late Adult
| -0.03 | (-0.07, 0.01) | -7871 | 0.04 | (-0.01, 0.10) |
-2279
|
Current
|
-0.04
|
(-0.07, -0.01)
| -7874 | 0.01 | (-0.05 0.07) | -2277 |
Accumulation Model
c
| -7885 | -2274 | ||||
0
| 0 | 0 | ||||
1
| -0.02 | (-0.07, 0.02) | 0.02 | (-0.07, 0.11) | ||
2
|
-0.05
|
(-0.10, -0.01)
| 0.05 | (-0.03, 0.13) | ||
3
|
-0.10
|
(-0.14, -0.05)
| 0.04 | (-0.05, 0.12) | ||
4
|
-0.09
|
(-0.15, -0.03)
| 0.10 | (-0.01, 0.21) | ||
Sensitive Periods Modeld
| -7891 | -2274 | ||||
Childhood
| -0.02 | (-0.05, 0.01) | 0.02 | (-0.03, 0.08) | ||
Early Adult
|
-0.07
|
(-0.10, -0.04)
| 0.02 | (-0.04, 0.08) | ||
Late Adult
| 0.00 | (-0.04, 0.04) | 0.04 | (-0.02, 0.10) | ||
Current
| -0.01 | (-0.05, 0.02) | 0.00 | (-0.06, 0.06) | ||
Fully Saturated Modele
| -7882 | -2262 |
Discussion
Conclusions
Appendix
White Blood Cell Count (109/L) | Granulocyte Cell Count (109/L) | |||||
---|---|---|---|---|---|---|
Δ | 95% CI | AIC | Δ | 95% CI | AIC | |
Men and Women
| ||||||
Critical Period Modelb
| ||||||
Childhood
|
-0.13
|
(-0.19, -0.06)
| 8789 |
-0.09
|
(-0.14, -0.04)
| 3967 |
Early Adult
|
-0.31*
|
(-0.38, -0.24)
| 8725 |
-0.23
|
(-0.29, -0.18)
| 3907 |
Late Adult
|
-0.18*
|
(-0.27, -0.10)
| 8779 |
-0.16
|
(-0.22, -0.09)
| 3951 |
Current
|
-0.18
|
(-0.25, -0.12)
| 8769 |
-0.15
|
(-0.20, -0.09)
| 3944 |
Accumulation Model
c
| 8722 | 3901 | ||||
0
| 0 | 0 | ||||
1
|
-0.17
|
(-0.27, -0.07)
|
-0.13
|
(-0.21, -0.05)
| ||
2
|
-0.28
|
(-0.37, -0.18)
|
-0.21
|
(-0.28, -0.13)
| ||
3
|
-0.42
|
(-0.52, -0.32)
|
-0.32
|
(-0.40, -0.24)
| ||
4
|
-0.46
|
(-0.59, -0.32)
|
-0.37
|
(-0.47, -0.26)
| ||
Sensitive Periods Modeld
|
8713
|
3892
| ||||
Childhood
| -0.06 | (-0.13, 0.01) | -0.04 | (-0.09, 0.02) | ||
Early Adult
|
-0.24
|
(-0.32, -0.17)
|
-0.18
|
(-0.24, -0.12)
| ||
Late Adult
| -0.08 | (-0.16, 0.01) |
-0.07
|
(-0.14, -0.01)
| ||
Current
|
-0.10
|
(-0.18, -0.03)
|
-0.08
|
(-0.14, -0.02)
| ||
Fully Saturated Modele
| 8725 | 3907 |
Women (n = 7,445) | Men (n = 2,536) | |||||
---|---|---|---|---|---|---|
Δ | 95% CI | AIC | Δ | 95% CI | AIC | |
Critical period Modelb
| ||||||
Childhood
|
-0.03
|
(-0.06, -0.01)
| -7876 | 0.03 | (-0.02, 0.09) | -2354 |
Early Adult
|
-0.08
|
(-0.11, -0.05)
|
-7894
|
0.07
|
(0.02, 0.13)
|
-2360
|
Late Adult
| -0.03 | (-0.07, 0.01) | -7873 |
0.06
|
(0.003, 0.11)
| -2358 |
Current
|
-0.03
|
(-0.06, -0.001)
| -7876 | 0.03 | (-0.02, 0.09) | -2355 |
Accumulation Model
c
| -7885 | -2357 | ||||
0
| 0 | 0 | ||||
1
| -0.02 | (-0.07, 0.02) | 0.04 | (-0.05, 0.12) | ||
2
|
-0.05
|
(-0.10, -0.01)
|
0.08
|
(0.004, 0.16)
| ||
3
|
-0.09
|
(-0.13, -0.04)
|
0.08
|
(0.001, 0.17)
| ||
4
|
-0.09
|
(-0.14, -0.03)
|
0.15
|
(0.03, 0.26)
| ||
Sensitive Periods Modeld
| -7891 | -2357 | ||||
Childhood
| -0.02 | (-0.05, 0.01) | 0.02 | (-0.03, 0.08) | ||
Early Adult
|
-0.07
|
(-0.10, -0.03)
| 0.06 | (-0.01, 0.12) | ||
Late Adult
| 0.00 | (-0.04, 0.04) | 0.04 | (-0.02, 0.10) | ||
Current
| -0.01 | (-0.04, 0.02) | 0.01 | (-0.05, 0.07) | ||
Fully Saturated Modele
| -7881 | -2345 |
White Blood Cell Count (109/L) | Granulocyte Cell Count (109/L) | |||||
---|---|---|---|---|---|---|
Δ | 95% CI | AIC | Δ | 95% CI | AIC | |
Men and Women
| ||||||
Critical period Modelb
| ||||||
Childhood
|
-0.13
|
(-0.19, -0.06)
| 8248 |
-0.09
|
(-0.14, -0.04)
| 3675 |
Early Adult
|
-0.31
|
(-0.38, -0.24)
| 8206 |
-0.24
|
(-0.29, -0.18)
| 3631 |
Late Adult
|
-0.20
|
(-0.27, -0.12)
| 8239 |
-0.17
|
(-0.23, -0.10)
| 3659 |
Current
|
-0.20
|
(-0.27, -0.14)
| 8223 |
-0.16
|
(-0.21, -0.11)
| 3646 |
Accumulation Model
c
| 3611 | |||||
0
| 0 | 8186.0 | 0 | |||
1
|
-0.19
|
(-0.29, -0.09)
|
-0.14
|
(-0.22, -0.06)
| ||
2
|
-0.28
|
(-0.37, -0.18)
|
-0.21
|
(-0.29, -0.14)
| ||
3
|
-0.40
|
(-0.50, -0.30)
|
-0.31
|
(-0.39, -0.23)
| ||
4
|
-0.42
|
(-0.56, -0.29)
|
-0.35
|
(-0.45, -0.24)
| ||
Sensitive Periods Modeld
|
8185.9
|
3608
| ||||
Childhood
| -0.06 | (-0.13, 0.01) | -0.04 | (-0.09, 0.02) | ||
Early Adult
|
-0.18
|
(-0.25, -0.10)
|
-0.14
|
(-0.20, -0.08)
| ||
Late Adult
| -0.08 | (-0.16, 0.00) |
-0.08
|
(-0.14, -0.02)
| ||
Current
|
-0.12
|
(-0.20, -0.05)
|
-0.10
|
(-0.15, -0.05)
| ||
Fully Saturated Modele
| 8198 | 3624 |
Women (n = 7,445) | Men (n = 2,536) | |||||
---|---|---|---|---|---|---|
Δ | 95% CI | AIC | Δ | 95% CI | AIC | |
Critical period Modelb
| ||||||
Childhood
|
-0.03
|
(-0.06, -0.01)
| -8283 | 0.03 | (-0.02, 0.09) | -2438 |
Early Adult
|
-0.08
|
(-0.11, -0.05)
|
-8288
|
0.07
|
(0.02, 0.13)
|
-2443
|
Late Adult
| -0.03 | (-0.06, 0.01) | -8278 |
0.05
|
(0.00, 0.11)
| -2440 |
Current
|
-0.03
|
(-0.06, -0.01)
| -8281 | 0.03 | (-0.02, 0.09) | -2438 |
Accumulation Model
c
| -8284 | -2439 | ||||
0
| 0* | 0* | ||||
1
| -0.03 | (-0.08, 0.01) | 0.02 | (-0.06, 0.10) | ||
2
| -0.04 | (-0.08, 0.002) | 0.07 | (-0.01, 0.15) | ||
3
|
-0.07
|
(-0.12, -0.02)
| 0.07 | (-0.02, 0.15) | ||
4
|
-0.06
|
(-0.12, -0.0003)
|
0.13
|
(0.02, 0.24)
| ||
Sensitive Periods Modeld
| -8285 | -2440 | ||||
Childhood
| -0.02 | (-0.05, 0.01) | 0.02 | (-0.04, 0.08) | ||
Early Adult
|
-0.04
|
(-0.07, -0.01)
|
0.06
|
(0.002, 0.12)
| ||
Late Adult
| 0.01 | (-0.03, 0.05) | 0.03 | (-0.03, 0.09) | ||
Current
| -0.01 | (-0.04, 0.02) | 0.00 | (-0.06, 0.06) | ||
Fully Saturated Modele
| -8274 | -2428 |
White Blood Cell Count (109/L) | Granulocyte Cell Count (109/L) | |||||||
---|---|---|---|---|---|---|---|---|
N | Δ | 95% CI | AIC | N | Δ | 95% CI | AIC | |
Men and Women
| ||||||||
Critical period Modelb
| ||||||||
Childhood
| 9683 |
-0.14
|
(-0.21, -0.07)
| 8769 | 9683 |
-0.10
|
(-0.15, -0.04)
| 4038 |
Early Adult
| 9976 |
-0.35
|
(-0.42, -0.29)
| 8906 | 9976 |
-0.26
|
(-0.31, -0.21)
| 4018 |
Late Adult
| 8808 |
-0.23
|
(-0.31, -0.15)
| 7901 | 8808 |
-0.19
|
(-0.25, -0.12)
| 3575 |
Current
| 8332 |
-0.23
|
(-0.30, -0.16)
| 7446 | 8332 |
-0.17
|
(-0.23, -0.12)
| 3362 |
Accumulation Model
c
| 6327 | 2872 | ||||||
0
| 7117 | 0 | 7117 | 0.00 | ||||
1
| 7117 |
-0.19
|
(-0.31, -0.07)
| 7117 |
-0.18
|
(-0.28, -0.08)
| ||
2
| 7117 |
-0.38
|
(-0.50, -0.26)
| 7117 |
-0.30
|
(-0.40, -0.21)
| ||
3
| 7117 |
-0.54
|
(-0.66, -0.42)
| 7117 |
-0.43
|
(-0.52, -0.33)
| ||
4
| 7117 |
-0.53
|
(-0.69, -0.38)
| 7117 |
-0.42
|
(-0.55, -0.30)
| ||
Sensitive Periods Modeld
| 6299 | 2851 | ||||||
Childhood
| 7112 | -0.05 | (-0.13, 0.03) | 7112 | -0.03 | (-0.09, 0.04) | ||
Early Adult
| 7112 |
-0.35
|
(-0.44, -0.26)
| 7112 |
-0.25
|
(-0.32, -0.18)
| ||
Late Adult
| 7112 | -0.07 | (-0.16, 0.02) | 7112 | -0.07 | (-0.14, -0.002) | ||
Current
| 7112 |
-0.12
|
(-0.20, -0.05)
| 7112 |
-0.10
|
(-0.16, -0.03)
| ||
Fully Saturated Model e
| 7112 | 6310 | 7112 | 2864 |
Women (n = 7,445) | Men (n = 2,536) | |||||||
---|---|---|---|---|---|---|---|---|
N | Δ | 95% CI | AIC | N | Δ | 95% CI | AIC | |
Critical period Modelb
| ||||||||
Childhood
| 7207 |
-0.04
|
(-0.07, -0.01)
| -7619 | 2476 | 0.03 | (-0.03, 0.08) | -2206 |
Early Adult
| 7443 |
-0.08
|
(-0.11, -0.05)
| -7893 | 2533 | 0.03 | (-0.02, 0.09) | -2274 |
Late Adult
| 6436 | -0.03 | (-0.07, 0.01) | -6835 | 2372 | 0.04 | (-0.02, 0.09) | -2118 |
Current
| 6166 |
-0.04
|
(-0.07, -0.01)
| -6589 | 2166 | 0.01 | (-0.05, 0.06) | -1982 |
Accumulation Model
c
| -5520 | -1783 | ||||||
0 | 0.00 | 1981 | 0.00 | |||||
1
| 5136 | 0.02 | (-0.04, 0.07) | 1981 | 0.03 | (-0.08, 0.13) | ||
2
| 5136 | -0.04 | (-0.10, 0.01) | 1981 | 0.07 | (-0.03, 0.16) | ||
3
| 5136 |
-0.10
|
(-0.15, -0.04)
| 1981 | 0.08 | (-0.02, 0.17) | ||
4
| 5136 |
-0.07
|
(-0.14, -0.002)
| 1981 | 0.07 | (-0.05, 0.20) | ||
Sensitive Periods Modeld
| -5512 | -1782 | ||||||
Childhood
| 5131 | -0.03 | (-0.06, 0.01) | 1981 | 0.03 | (-0.03, 0.09) | ||
Early Adult
| 5131 |
-0.08
|
(-0.12, -0.04)
| 1981 | -0.01 | (-0.08, 0.06) | ||
Late Adult
| 5131 | 0.02 | (-0.03, 0.06) | 1981 | 0.03 | (-0.03, 0.09) | ||
Current
| 5131 | -0.01 | (-0.05, 0.02) | 1981 | -0.01 | (-0.06, 0.05) | ||
Fully Saturated Modele
| 5131 | -7222 | 1981 | -7222 |