Introduction
With the advent of novel treatments, the life expectancy of lymphoma patients, including pediatric cases, has been significantly extended. However, this progress has given rise to a new and serious concern—the development of second primary malignancies (SPMs). In adult patients, especially those with specific lymphoma subtypes, previous studies have explored the relationships between SPMs and factors such as genetic vulnerability, family history, immunodeficiency, environmental exposure, and various treatment modalities (Chattopadhyay et al.
2020; Chien et al.
2015; Chowdhry et al.
2015; Hemminki et al.
2003; Joelsson et al.
2022; Sud et al.
2017). Yet, there remains a noticeable gap in the research literature when it comes to a comprehensive investigation into pediatric lymphoma survivors, encompassing all subtypes of Hodgkin lymphoma (HL) and non-Hodgkin lymphoma (NHL).
The National Cancer Institute’s Surveillance, Epidemiology, and End Results (SEER) Program, which aggregates data from nearly one-third of the U.S. cancer patient population, provides an invaluable resource for filling this void. Our study, based on SEER database registries, sought to identify patients who received their initial primary lymphoma diagnosis at the age of 19 or younger between 1975 and 2018. We defined SPM as a subsequent malignancy diagnosed at least one year after the initial primary lymphoma diagnosis, excluding individuals who passed away or developed an SPM within the first year following the lymphoma diagnosis.
In examining this research gap and leveraging the extensive SEER database, our study aims to explore the risk factors and incidence rates of SPMs within the unique context of pediatric lymphoma survivors. While acknowledging that previous research has extensively examined these aspects in this population, our study's principal strength lies in the inclusion of a large number of patients, facilitating substantial confirmation of previously identified risk factors. The extended follow-up time further enhances the robustness of our findings. This investigation holds particular relevance due to the distinctive challenges and concerns faced by this specific patient group, necessitating dedicated and comprehensive research. The meticulous definition of SPM in this context, coupled with the exclusion criteria, ensures the precision and relevance of our findings to the pediatric lymphoma survivor population.
Discussion
Advancements in lymphoma treatments have significantly extended the life expectancy of patients, creating a growing concern, especially for the pediatric population with the emergence of SPMs. This study aimed to delve into the lifetime risks of SPMs after pediatric HL and NHL, utilizing the comprehensive SEER database.
Our findings revealed a remarkable 4.36-fold increase in the risk of SPMs among pediatric lymphoma survivors, underscoring the gravity of this issue. The risk of SPMs varied among subgroups, with sex, age, race, latency since diagnosis, primary lymphoma site, subtype, Ann Arbor stage, and treatment modalities all playing significant roles. Of particular importance was the identification of the highest SIR within the initial 1–5 years following lymphoma diagnosis, emphasizing an early vulnerability window. These results stress the necessity for prolonged surveillance and vigilance among pediatric lymphoma survivors. Notably, distinct histological subtypes of lymphoma carried significantly elevated SPM risks, accentuating the need for a subtype-specific approach to patient care. The associations observed with certain subtypes such as nodular lymphocyte-predominant HL, B-cell precursor NHL, T-cell precursor NHL, and mycosis fungoides underscore the importance of considering this diversity and the potential immune vulnerability within the pediatric lymphoma population (Chihara et al.
2021; Moser et al.
2021).
Furthermore, this research disclosed a substantial and increasing risk of SPMs over a 40-year timeframe, particularly for NHL and HL survivors. Breast and thyroid cancers were the predominant SPMs, highlighting the need for tailored screening and preventative strategies, especially for female patients. Several studies reported a similar incidence of SPMs (about 5%) for pediatric NHL (Bluhm et al.
2008; Friedman et al.
2010; Leung et al.
2001; Moser et al.
2021), but we report here for the first time a much higher 40-year cumulative incidence for both NHL (12.6%) and HL (22.2%), suggesting a lifetime effect.. The increased incidence of SPMs over time emphasizes the severe threat to pediatric lymphoma patients, necessitating more frequent and earlier malignancy screenings throughout their lives. These findings underscore the importance of personalized, lifelong care and screening protocols for this unique patient population to mitigate the impact of SPMs on their health and well-being.
While previous studies on SPMs among pediatric lymphoma survivors have been limited by sample size, this research has quantitatively analyzed influential factors. Gender, lymphoma subtype, and treatment modalities emerged as critical determinants of SPM risk. Female patients, irrespective of lymphoma subtype, exhibited a heightened susceptibility to SPMs, with HL patients at increased risk compared to NHL cases. Notably, the study for the first time demonstrated a 3.59-fold elevated risk of second primary thyroid cancer in females compared to males. These findings underline the significance of individualized care and long-term follow-up for this patient population.
Though previous research has indicated treatment-related SPM risks, few have explored whether CT or RT could accelerate SPM development (Morton et al.
2010; Moser et al.
2021). This study sheds further light on the impacts of treatment modalities on SPM risk. It is noteworthy that while CT did not elevate the overall SPM incidence, it significantly expedited SPM development in pediatric HL cases. This highlights the need for close monitoring and management of patients receiving CT, enabling the early detection of SPMs. The data indicate a correlation between CT and the accelerated development of certain SPMs, especially leukemia. However, it is essential to consider the multifactorial nature of cancer development and the potential influence of treatment modalities. This underscores the importance of close monitoring and management of patients undergoing CT, focusing on early detection of SPMs, particularly in the context of the observed heightened risk in pediatric HL cases, especially in the leukemia category. Furthermore, radiotherapy was linked to a substantial increase in SPM risk, especially for certain secondary cancers like female breast cancer. Importantly, the adverse effects of RT were characterized by a considerable delay, emphasizing the necessity of long-term observation and surveillance.
Nevertheless, it is crucial to acknowledge specific limitations in our study. Most notably, we were unable to provide detailed treatment information, encompassing cumulative doses of chemotherapeutic drugs or radiation. Unfortunately, the SEER database did not furnish detailed information about the location of RT in our study, thereby limiting our ability to explore the relationship between the location of RT and the subsequent occurrence of SPMs. Additionally, our study does not delve into the evolving landscape of treatment strategies over the 40-year period, a facet we recognize as crucial. Furthermore, our investigation did not explore the influence of biological, immunological, or other predisposing factors in the development of SPMs. In addition to these limitations, it is essential to note that the SEER program is a widely used comprehensive cancer registry system in the United States, covering approximately one-third of the population. While we acknowledge that no population-based registry can be entirely exhaustive, the SEER program is designed to be as representative as possible, drawing from diverse geographic regions and population groups. Regarding the quality and completeness of data, the SEER program employs rigorous data collection and quality control measures. We acknowledge any potential limitations in completeness, recognizing the inherent trade-offs in data integrity.
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