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Erschienen in:
05.10.2019 | Clinical Case Report
Linezolid-induced photoreceptor dysfunction masquerading as autoimmune retinopathy
Erschienen in: Documenta Ophthalmologica | Ausgabe 1/2020
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Purpose
To report a case of linezolid-induced reversible retinopathy.
Methods
Case report with literature review.
Results
Clinical examination and imaging are presented over a 7-month interval, from initial presentation to subsequent follow-up (6 months after discontinuation of linezolid). The subject was found to have not only an optic neuropathy but also severe reversible photoreceptor dysfunction as demonstrated by electrophysiologic testing. Upon discontinuation of linezolid, not only did the patient’s visual acuity, visual fields, and visual evoked potential significantly improve, but the electroretinogram did as well.
Conclusions
Linezolid has previously been reported to cause a toxic optic neuropathy. Reversible photoreceptor dysfunction on full-field electroretinography has never been reported in conjunction with linezolid toxicity. This novel case suggests that linezolid toxicity should be considered in cases of photoreceptor dysfunction.