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Diabetologia

Erschienen in:

01.04.2008 | Review

Arterial stiffness in diabetes and the metabolic syndrome: a pathway to cardiovascular disease

verfasst von: C. D. A. Stehouwer, R. M. A. Henry, I. Ferreira

Erschienen in: Diabetologia | Ausgabe 4/2008

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Abstract

Increased arterial stiffness associated with diabetes and the metabolic syndrome may in part explain the increased cardiovascular disease risk observed in these conditions. Arterial stiffness can be estimated by quantifying pulse pressure but is better described by distensibility and compliance coefficients, pulse wave velocity and wave reflection. The most common non-invasive methodologies used to quantify these estimates of arterial stiffness (e.g. ultrasonography and applanation tonometry) are also described. We then review and summarise the current data on the associations between diabetes, the metabolic syndrome and insulin resistance on the one hand and greater arterial stiffness on the other, and identify and discuss some unresolved issues such as differential stiffening of central vs peripheral arterial segments, the impact of sex, and the pathobiology of increased arterial stiffness in diabetes and the metabolic syndrome. Finally, some considerations with regard to treatment options are presented. At present the most powerful therapy available for reducing arterial stiffness is to vigorously treat hypertension using pharmacological agents. New pharmacological strategies to reduce arterial stiffness are likely to be especially relevant to individuals with diabetes.

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Titel: Arterial stiffness in diabetes and the metabolic syndrome: a pathway to cardiovascular disease
verfasst von: C. D. A. Stehouwer
R. M. A. Henry
I. Ferreira
Publikationsdatum: 01.04.2008
Verlag: Springer-Verlag
Erschienen in: Diabetologia / Ausgabe 4/2008
Print ISSN: 0012-186X
Elektronische ISSN: 1432-0428
DOI: https://doi.org/10.1007/s00125-007-0918-3

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Update Innere Medizin

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Die Highlights vom Kongress des American College of Cardiology 2024

Springer Medizin

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