Introduction
Methods
Results
Category and annotations |
p value | Molecules | No. molecules |
---|---|---|---|
Cell-to-cell signalling and interaction | |||
Synaptic transmission | 7.93 × 10−6
| DPP6, GLRB, SLC12A5, SLC17A7, SLC1A3, SV2A, SV2B, VDAC1 | 8 |
Long-term potentiation | 4.10 × 10−3
| DPP6, KRAS, SLC17A7, SYNGR1, VDAC1 | 5 |
Long-term potentiation of synapse | 4.59 × 10−3
| DPP6, SLC17A7, SYNGR1, VDAC1 | 4 |
Accumulation of 5-hydroxytryptamine | 4.81 × 10−3
| MAOA | 1 |
Sequestration of neurotransmitter | 4.81 × 10−3
| SLC17A7 | 1 |
Release of l-glutamic acid | 6.87 × 10−3
| SLC17A7, SLC1A3 | 2 |
Paired-pulse facilitation of synapse | 1.81 × 10−2
| SYNGR1, VDAC1 | 2 |
Aggregation of neurons | 2.38 × 10−2
| ATP1B1 | 1 |
Catabolism of dopamine | 2.38 × 10−2
| MAOA | 1 |
Plasticity of synapse | 4.23 × 10−2
| KRAS, SYNGR1 | 2 |
Formation of adherens junctions | 4.25 × 10−2
| KRAS | 1 |
Cellular assembly and organisation | |||
Activation of permeability transition pores | 2.28 × 10−5
| SLC25A4, SLC25A5 | 2 |
Fragmentation of microtubules | 4.81 × 10−3
| TUBB | 1 |
Organisation of axon terminals | 4.81 × 10−3
| MAOA | 1 |
Expansion of thalamocortical axons | 9.59 × 10−3
| MAOA | 1 |
Quantity of thalamocortical axons | 9.59 × 10−3
| MAOA | 1 |
Segregation of sensory projections | 9.59 × 10−3
| MAOA | 1 |
Morphology of Golgi apparatus | 1.44 × 10−2
| TMED10 | 1 |
Organisation of Golgi apparatus | 2.85 × 10−2
| TMED10 | 1 |
Formation of adherens junctions | 4.25 × 10−2
| KRAS | 1 |
Morphology of mitochondria | 4.35 × 10−2
| NDUFA13, SLC25A4 | 2 |
Amino acid metabolism | |||
Import of l-glutamic acid | 6.81 × 10−5
| SLC17A7, SLC1A3 | 2 |
Synthesis of GABA | 4.81 × 10−3
| SLC1A3 | 1 |
Synthesis of l-glutamic acid | 4.81 × 10−3
| SLC1A3 | 1 |
Release of l-glutamic acid | 6.87 × 10−3
| SLC17A7, SLC1A3 | 2 |
Metabolism of l-glutamic acid | 1.91 × 10−2
| SLC1A3 | 1 |
Molecular transport | |||
Import of l-glutamic acid | 6.81 × 10−5
| SLC17A7, SLC1A3 | 2 |
Transport of anions | 1.39 × 10−4
| GLRB, SLC12A5, SLC4A3, VDAC1 | 4 |
Transport of ions | 5.13 × 10−4
| ATP2B1, CAMK2D, CAMK2G, GLRB, SLC12A5, SLC4A3, VDAC1 | 7 |
Transport of molecules | 1.51 × 10−3
| ATP2B1, CAMK2D, CAMK2G, GLRB, SLC12A5, SLC17A7, SLC1A3, SLC4A3, TMED10, VDAC1 | 10 |
Transport of Ca2+
| 3.14 × 10−3
| ATP2B1, CAMK2D, CAMK2G | 3 |
Accumulation of 5-hydroxytryptamine | 4.81 × 10−3
| MAOA | 1 |
Exchange of ADP | 4.81 × 10−3
| SLC25A4 | 1 |
Exchange of ATP | 4.81 × 10−3
| SLC25A4 | 1 |
Release of lactic acid | 4.81 × 10−3
| SLC1A3 | 1 |
Translocation of ADP | 4.81 × 10−3
| VDAC1 | 1 |
Release of l-glutamic acid | 6.87 × 10−3
| SLC17A7, SLC1A3 | 2 |
Transport of chloride | 6.87 × 10−3
| GLRB, SLC12A5 | 2 |
Redistribution of cholesterol | 1.91 × 10−2
| ATP1A1 | 1 |
Transport of cations | 2.47 × 10−2
| ATP2B1, CAMK2D, CAMK2G, SLC12A5 | 4 |
Small-molecule biochemistry | |||
Import of l-glutamic acid | 6.81 × 10−5
| SLC17A7, SLC1A3 | 2 |
Accumulation of 5-hydroxytryptamine | 4.81 × 10−3
| MAOA | 1 |
Exchange of ADP | 4.81 × 10−3
| SLC25A4 | 1 |
Exchange of ATP | 4.81 × 10−3
| SLC25A4 | 1 |
Oxidation of lactic acid | 4.81 × 10−3
| MLXIPL | 1 |
Release of lactic acid | 4.81 × 10−3
| SLC1A3 | 1 |
Sequestration of neurotransmitters | 4.81 × 10−3
| SLC17A7 | 1 |
Synthesis of GABA | 4.81 × 10−3
| SLC1A3 | 1 |
Synthesis of l-glutamic acid | 4.81 × 10−3
| SLC1A3 | 1 |
Translocation of ADP | 4.81 × 10−3
| VDAC1 | 1 |
Release of l-glutamic acid | 6.87 × 10−3
| SLC17A7, SLC1A3 | 2 |
Metabolism of l-glutamic acid | 1.91 × 10−2
| SLC1A3 | 1 |
Redistribution of cholesterol | 1.91 × 10−2
| ATP1A1 | 1 |
Catabolism of dopamine | 2.38 × 10−2
| MAOA | 1 |
Synthesis of glucocorticoids | 2.85 × 10−2
| ATP1A1 | 1 |
Category and annotations |
p value | Molecules | No. molecules |
---|---|---|---|
Cell death and survival | |||
Recovery of retinal rods | 1.17 × 10−6
| ABCA4, RGS9BP | 2 |
Delay in recovery of retinal rods | 1.11 × 10−3
| ABCA4 | 1 |
Apoptosis of endothelial cell lines | 4.45 × 10−3
| CDH2 | 1 |
Apoptosis of photoreceptors | 1.22 × 10−3
| ROM1 | 1 |
Cellular compromise | |||
Degeneration of photoreceptors | 1.07 × 10−3
| ABCA4, ROM1 | 2 |
Neurodegeneration of photoreceptors | 6.67 × 10−3
| ROM1 | 1 |
Degeneration of retinal rods | 1.33 × 10−2
| ROM1 | 1 |
Amino acid metabolism | |||
Transport of l-histidine | 1.11 × 10−3
| SLC38A3 | 1 |
Transport of l-glutamine | 2.23 × 10−3
| SLC38A3 | 1 |
Carbohydrate metabolism | |||
Quantity of N-retinylidene-phosphatidylethanolamine | 1.11 × 10−3
| ABCA4 | 1 |
Cell morphology | |||
Size of rod outer segment disks | 1.11 × 10−3
| ROM1 | 1 |
Abnormal morphology of photoreceptor outer segments | 1.12 × 10−3
| ABCA4, ROM1 | 2 |
Blebbing of nucleus | 2.23 × 10−3
| LMNB1 | 1 |
Length of rod outer segments | 4.45 × 10−3
| ROM1 | 1 |
Abnormal morphology of rod outer segments | 1.55 × 10−2
| ROM1 | 1 |
Innervation of muscle | 2.43 × 10−2
| LMNB1 | 1 |
Abnormal morphology of photoreceptors | 3.73 × 10−2
| ABCA4 | 1 |
Extension of axons | 4.16 × 10−2
| CDH2 | 1 |