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Erschienen in: Diabetologia 12/2022

24.09.2022 | Consensus report

Management of hyperglycaemia in type 2 diabetes, 2022. A consensus report by the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD)

verfasst von: Melanie J. Davies, Vanita R. Aroda, Billy S. Collins, Robert A. Gabbay, Jennifer Green, Nisa M. Maruthur, Sylvia E. Rosas, Stefano Del Prato, Chantal Mathieu, Geltrude Mingrone, Peter Rossing, Tsvetalina Tankova, Apostolos Tsapas, John B. Buse

Erschienen in: Diabetologia | Ausgabe 12/2022

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Abstract

The American Diabetes Association and the European Association for the Study of Diabetes convened a panel to update the previous consensus statements on the management of hyperglycaemia in type 2 diabetes in adults, published since 2006 and last updated in 2019. The target audience is the full spectrum of the professional healthcare team providing diabetes care in the USA and Europe. A systematic examination of publications since 2018 informed new recommendations. These include additional focus on social determinants of health, the healthcare system and physical activity behaviours including sleep. There is a greater emphasis on weight management as part of the holistic approach to diabetes management. The results of cardiovascular and kidney outcomes trials involving sodium–glucose cotransporter-2 inhibitors and glucagon-like peptide-1 receptor agonists, including assessment of subgroups, inform broader recommendations for cardiorenal protection in people with diabetes at high risk of cardiorenal disease. After a summary listing of consensus recommendations, practical tips for implementation are provided.

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Literatur
2.
Zurück zum Zitat American Diabetes Association Professional Practice Committee; Draznin B, Aroda VR, Bakris G et al (2022) 6. Glycemic targets: standards of medical care in diabetes – 2022. Diabetes Care 45(Suppl 1):S83–S96. https://doi.org/10.2337/dc22-S006 American Diabetes Association Professional Practice Committee; Draznin B, Aroda VR, Bakris G et al (2022) 6. Glycemic targets: standards of medical care in diabetes – 2022. Diabetes Care 45(Suppl 1):S83–S96. https://​doi.​org/​10.​2337/​dc22-S006
3.
4.
7.
Zurück zum Zitat Schandelmaier S, Briel M, Varadhan R et al (2020) Development of the Instrument to assess the Credibility of Effect Modification Analyses (ICEMAN) in randomized controlled trials and meta-analyses. CMAJ 192(32):E901–E906. https://doi.org/10.1503/cmaj.200077 Schandelmaier S, Briel M, Varadhan R et al (2020) Development of the Instrument to assess the Credibility of Effect Modification Analyses (ICEMAN) in randomized controlled trials and meta-analyses. CMAJ 192(32):E901–E906. https://​doi.​org/​10.​1503/​cmaj.​200077
16.
Zurück zum Zitat American Diabetes Association Professional Practice Committee; Draznin B, Aroda VR, Bakris G et al (2022) 9. Pharmacologic approaches to glycemic treatment: Standards of Medical Care in Diabetes – 2022. Diabetes Care 45(Suppl 1):S125–S143. https://doi.org/10.2337/dc22-S009 American Diabetes Association Professional Practice Committee; Draznin B, Aroda VR, Bakris G et al (2022) 9. Pharmacologic approaches to glycemic treatment: Standards of Medical Care in Diabetes – 2022. Diabetes Care 45(Suppl 1):S125–S143. https://​doi.​org/​10.​2337/​dc22-S009
17.
Zurück zum Zitat Crabtree T, Ogendo JJ, Vinogradova Y, Gordon J, Idris I (2022) Intensive glycemic control and macrovascular, microvascular, hypoglycemia complications and mortality in older (age ≥60years) or frail adults with type 2 diabetes: a systematic review and meta-analysis from randomized controlled trial and observation studies. Expert Rev Endocrinol Metab 17(3):255–267. https://doi.org/10.1080/17446651.2022.2079495CrossRefPubMed Crabtree T, Ogendo JJ, Vinogradova Y, Gordon J, Idris I (2022) Intensive glycemic control and macrovascular, microvascular, hypoglycemia complications and mortality in older (age ≥60years) or frail adults with type 2 diabetes: a systematic review and meta-analysis from randomized controlled trial and observation studies. Expert Rev Endocrinol Metab 17(3):255–267. https://​doi.​org/​10.​1080/​17446651.​2022.​2079495CrossRefPubMed
19.
Zurück zum Zitat Powers MA, Bardsley JK, Cypress M et al (2020) Diabetes self-management education and support in adults with type 2 diabetes: a consensus report of the American Diabetes Association, the Association of Diabetes Care and Education Specialists, the Academy of Nutrition and Dietetics, the American Academy of Family Physicians, the American Academy of PAs, the American Association of Nurse Practitioners, and the American Pharmacists Association. Diabetes Care 43(7):1636–1649. https://doi.org/10.2337/dci20-0023CrossRefPubMed Powers MA, Bardsley JK, Cypress M et al (2020) Diabetes self-management education and support in adults with type 2 diabetes: a consensus report of the American Diabetes Association, the Association of Diabetes Care and Education Specialists, the Academy of Nutrition and Dietetics, the American Academy of Family Physicians, the American Academy of PAs, the American Association of Nurse Practitioners, and the American Pharmacists Association. Diabetes Care 43(7):1636–1649. https://​doi.​org/​10.​2337/​dci20-0023CrossRefPubMed
22.
Zurück zum Zitat American Diabetes Association Professional Practice Committee; Draznin B, Aroda VR, Bakris G et al (2022) 5. Facilitating behavior change and well-being to improve health outcomes: Standards of Medical Care in Diabetes – 2022. Diabetes Care 45(Suppl 1):S60–S82. https://doi.org/10.2337/dc22-S005 American Diabetes Association Professional Practice Committee; Draznin B, Aroda VR, Bakris G et al (2022) 5. Facilitating behavior change and well-being to improve health outcomes: Standards of Medical Care in Diabetes – 2022. Diabetes Care 45(Suppl 1):S60–S82. https://​doi.​org/​10.​2337/​dc22-S005
24.
28.
Zurück zum Zitat Odgers-Jewell K, Ball LE, Kelly JT, Isenring EA, Reidlinger DP, Thomas R (2017) Effectiveness of group-based self-management education for individuals with type 2 diabetes: a systematic review with meta-analyses and meta-regression. Diabet Med 34(8):1027–1039. https://doi.org/10.1111/dme.13340CrossRefPubMed Odgers-Jewell K, Ball LE, Kelly JT, Isenring EA, Reidlinger DP, Thomas R (2017) Effectiveness of group-based self-management education for individuals with type 2 diabetes: a systematic review with meta-analyses and meta-regression. Diabet Med 34(8):1027–1039. https://​doi.​org/​10.​1111/​dme.​13340CrossRefPubMed
36.
54.
Zurück zum Zitat Mannucci E, Antenore A, Giorgino F, Scavini M (2018) Effects of structured versus unstructured self-monitoring of blood glucose on glucose control in patients with non-insulin-treated type 2 diabetes: a meta-analysis of randomized controlled trials. J Diabetes Sci Technol 12(1):183–189. https://doi.org/10.1177/1932296817719290CrossRefPubMed Mannucci E, Antenore A, Giorgino F, Scavini M (2018) Effects of structured versus unstructured self-monitoring of blood glucose on glucose control in patients with non-insulin-treated type 2 diabetes: a meta-analysis of randomized controlled trials. J Diabetes Sci Technol 12(1):183–189. https://​doi.​org/​10.​1177/​1932296817719290​CrossRefPubMed
64.
Zurück zum Zitat Konstantinou P, Kassianos AP, Georgiou G et al (2020) Barriers, facilitators, and interventions for medication adherence across chronic conditions with the highest non-adherence rates: a scoping review with recommendations for intervention development. Transl Behav Med 10(6):1390–1398. https://doi.org/10.1093/tbm/ibaa118CrossRefPubMed Konstantinou P, Kassianos AP, Georgiou G et al (2020) Barriers, facilitators, and interventions for medication adherence across chronic conditions with the highest non-adherence rates: a scoping review with recommendations for intervention development. Transl Behav Med 10(6):1390–1398. https://​doi.​org/​10.​1093/​tbm/​ibaa118CrossRefPubMed
67.
68.
74.
82.
Zurück zum Zitat Corley BT, Carroll RW, Hall RM, Weatherall M, Parry-Strong A, Krebs JD (2018) Intermittent fasting in type 2 diabetes mellitus and the risk of hypoglycaemia: a randomized controlled trial. Diabet Med 35(5):588–594. https://doi.org/10.1111/dme.13595 Corley BT, Carroll RW, Hall RM, Weatherall M, Parry-Strong A, Krebs JD (2018) Intermittent fasting in type 2 diabetes mellitus and the risk of hypoglycaemia: a randomized controlled trial. Diabet Med 35(5):588–594. https://​doi.​org/​10.​1111/​dme.​13595
83.
Zurück zum Zitat O’Neil PM, Miller-Kovach K, Tuerk PW et al (2016) Randomized controlled trial of a nationally available weight control program tailored for adults with type 2 diabetes. Obesity (Silver Spring) 24(11):2269–2277. https://doi.org/10.1002/oby.21616 O’Neil PM, Miller-Kovach K, Tuerk PW et al (2016) Randomized controlled trial of a nationally available weight control program tailored for adults with type 2 diabetes. Obesity (Silver Spring) 24(11):2269–2277. https://​doi.​org/​10.​1002/​oby.​21616
90.
Zurück zum Zitat Wing RR, Look AHEAD Research Group (2021) Does lifestyle intervention improve health of adults with overweight/obesity and type 2 diabetes? Findings from the Look AHEAD randomized trial. Obesity (Silver Spring) 29(8):1246–1258. https://doi.org/10.1002/oby.23158 Wing RR, Look AHEAD Research Group (2021) Does lifestyle intervention improve health of adults with overweight/obesity and type 2 diabetes? Findings from the Look AHEAD randomized trial. Obesity (Silver Spring) 29(8):1246–1258. https://​doi.​org/​10.​1002/​oby.​23158
94.
Zurück zum Zitat Look AHEAD Research Group; Gregg E, Jakicic J, Blackburn G et al (2016) Association of the magnitude of weight loss and changes in physical fitness with long-term cardiovascular disease outcomes in overweight or obese people with type 2 diabetes: a post-hoc analysis of the Look AHEAD randomised clinical trial. Lancet Diabetes Endocrinol 4(11):913–921. https://doi.org/10.1016/S2213-8587(16)30162-0 Look AHEAD Research Group; Gregg E, Jakicic J, Blackburn G et al (2016) Association of the magnitude of weight loss and changes in physical fitness with long-term cardiovascular disease outcomes in overweight or obese people with type 2 diabetes: a post-hoc analysis of the Look AHEAD randomised clinical trial. Lancet Diabetes Endocrinol 4(11):913–921. https://​doi.​org/​10.​1016/​S2213-8587(16)30162-0
95.
Zurück zum Zitat Look AHEAD Research Group; Wing RR, Bray GA, Cassidy-Begay M et al Effects of intensive lifestyle intervention on all-cause mortality in older adults with type 2 diabetes and overweight/obesity: results from the Look AHEAD study. Diabetes Care 45(5):1252–1259. https://doi.org/10.2337/dc21-1805 Look AHEAD Research Group; Wing RR, Bray GA, Cassidy-Begay M et al Effects of intensive lifestyle intervention on all-cause mortality in older adults with type 2 diabetes and overweight/obesity: results from the Look AHEAD study. Diabetes Care 45(5):1252–1259. https://​doi.​org/​10.​2337/​dc21-1805
104.
106.
124.
Zurück zum Zitat American Diabetes Association Professional Practice Committee; Draznin B, Aroda VR, Bakris G et al (2022) 4. Comprehensive medical evaluation and assessment of comorbidities: Standards of Medical Care in Diabetes – 2022. Diabetes Care 45(Suppl 1):S46–S59. https://doi.org/10.2337/dc22-S004 American Diabetes Association Professional Practice Committee; Draznin B, Aroda VR, Bakris G et al (2022) 4. Comprehensive medical evaluation and assessment of comorbidities: Standards of Medical Care in Diabetes – 2022. Diabetes Care 45(Suppl 1):S46–S59. https://​doi.​org/​10.​2337/​dc22-S004
127.
Zurück zum Zitat American Diabetes Association Professional Practice Committee; Draznin B, Aroda VR, Bakris G et al (2022) 8. Obesity and weight management for the prevention and treatment of type 2 diabetes: Standards of Medical Care in Diabetes – 2022. Diabetes Care 45(Suppl 1):S113–S124. https://doi.org/10.2337/dc22-S008 American Diabetes Association Professional Practice Committee; Draznin B, Aroda VR, Bakris G et al (2022) 8. Obesity and weight management for the prevention and treatment of type 2 diabetes: Standards of Medical Care in Diabetes – 2022. Diabetes Care 45(Suppl 1):S113–S124. https://​doi.​org/​10.​2337/​dc22-S008
128.
Zurück zum Zitat Davies M, Færch L, Jeppesen OK et al (2021) Semaglutide 2.4 mg once a week in adults with overweight or obesity, and type 2 diabetes (STEP 2): a randomised, double-blind, double-dummy, placebo-controlled, phase 3 trial. Lancet 397(10278):971–984. https://doi.org/10.1016/S0140-6736(21)00213-0 Davies M, Færch L, Jeppesen OK et al (2021) Semaglutide 2.4 mg once a week in adults with overweight or obesity, and type 2 diabetes (STEP 2): a randomised, double-blind, double-dummy, placebo-controlled, phase 3 trial. Lancet 397(10278):971–984. https://​doi.​org/​10.​1016/​S0140-6736(21)00213-0
136.
139.
160.
Zurück zum Zitat Qian BB, Chen Q, Li L, Yan CF (2020) Association between combined treatment with SGLT2 inhibitors and metformin for type 2 diabetes mellitus on fracture risk: a meta-analysis of randomized controlled trials. Osteoporos Int 31(12):2313–2320. https://doi.org/10.1007/s00198-020-05590-y Qian BB, Chen Q, Li L, Yan CF (2020) Association between combined treatment with SGLT2 inhibitors and metformin for type 2 diabetes mellitus on fracture risk: a meta-analysis of randomized controlled trials. Osteoporos Int 31(12):2313–2320. https://​doi.​org/​10.​1007/​s00198-020-05590-y
161.
171.
Zurück zum Zitat Bethel MA, Diaz R, Castellana N, Bhattacharya I, Gerstein HC, Lakshmanan MC (2021) HbA1c change and diabetic retinopathy during GLP-1 receptor agonist cardiovascular outcome trials: a meta-analysis and meta-regression. Diabetes Care 44(1):290–296. https://doi.org/10.2337/dc20-1815 Bethel MA, Diaz R, Castellana N, Bhattacharya I, Gerstein HC, Lakshmanan MC (2021) HbA1c change and diabetic retinopathy during GLP-1 receptor agonist cardiovascular outcome trials: a meta-analysis and meta-regression. Diabetes Care 44(1):290–296. https://​doi.​org/​10.​2337/​dc20-1815
176.
183.
186.
Zurück zum Zitat Ludvik B, Giorgino F, Jódar E et al (2021) Once-weekly tirzepatide versus once-daily insulin degludec as add-on to metformin with or without SGLT2 inhibitors in patients with type 2 diabetes (SURPASS-3): a randomised, open-label, parallel-group, phase 3 trial. Lancet 398(10300):583–598. https://doi.org/10.1016/S0140-6736(21)01443-4 Ludvik B, Giorgino F, Jódar E et al (2021) Once-weekly tirzepatide versus once-daily insulin degludec as add-on to metformin with or without SGLT2 inhibitors in patients with type 2 diabetes (SURPASS-3): a randomised, open-label, parallel-group, phase 3 trial. Lancet 398(10300):583–598. https://​doi.​org/​10.​1016/​S0140-6736(21)01443-4
187.
188.
Zurück zum Zitat Gastaldelli A, Cusi K, Fernández Landó L, Bray R, Brouwers B, Rodríguez Á (2022) Effect of tirzepatide versus insulin degludec on liver fat content and abdominal adipose tissue in people with type 2 diabetes (SURPASS-3 MRI): a substudy of the randomised, open-label, parallel-group, phase 3 SURPASS-3 trial. Lancet Diabetes Endocrinol 10(6):393–406. https://doi.org/10.1016/S2213-8587(22)00070-5CrossRefPubMed Gastaldelli A, Cusi K, Fernández Landó L, Bray R, Brouwers B, Rodríguez Á (2022) Effect of tirzepatide versus insulin degludec on liver fat content and abdominal adipose tissue in people with type 2 diabetes (SURPASS-3 MRI): a substudy of the randomised, open-label, parallel-group, phase 3 SURPASS-3 trial. Lancet Diabetes Endocrinol 10(6):393–406. https://​doi.​org/​10.​1016/​S2213-8587(22)00070-5CrossRefPubMed
193.
Zurück zum Zitat Vaccaro O, Masulli M, Nicolucci A et al (2017) Effects on the incidence of cardiovascular events of the addition of pioglitazone versus sulfonylureas in patients with type 2 diabetes inadequately controlled with metformin (TOSCA.IT): a randomised, multicentre trial. Lancet Diabetes Endocrinol 5(11):887–897. https://doi.org/10.1016/S2213-8587(17)30317-0CrossRefPubMed Vaccaro O, Masulli M, Nicolucci A et al (2017) Effects on the incidence of cardiovascular events of the addition of pioglitazone versus sulfonylureas in patients with type 2 diabetes inadequately controlled with metformin (TOSCA.IT): a randomised, multicentre trial. Lancet Diabetes Endocrinol 5(11):887–897. https://​doi.​org/​10.​1016/​S2213-8587(17)30317-0CrossRefPubMed
197.
Zurück zum Zitat Dormandy JA, Charbonnel B, Eckland DJA et al (2005) Secondary prevention of macrovascular events in patients with type 2 diabetes in the PROactive Study (PROspective pioglitAzone Clinical Trial In macroVascular Events): a randomised controlled trial. Lancet 366(9493):1279–1289. https://doi.org/10.1016/S0140-6736(05)67528-9 Dormandy JA, Charbonnel B, Eckland DJA et al (2005) Secondary prevention of macrovascular events in patients with type 2 diabetes in the PROactive Study (PROspective pioglitAzone Clinical Trial In macroVascular Events): a randomised controlled trial. Lancet 366(9493):1279–1289. https://​doi.​org/​10.​1016/​S0140-6736(05)67528-9
202.
215.
Zurück zum Zitat Maiorino MI, Chiodini P, Bellastella G et al (2018) Free and fixed-ratio combinations of basal insulin and GLP-1 receptor agonists versus basal insulin intensification in type 2 diabetes: a systematic review and meta-analysis of randomized controlled trials. Diabetes Obes Metab 20(9):2309–2313. https://doi.org/10.1111/dom.13343CrossRefPubMed Maiorino MI, Chiodini P, Bellastella G et al (2018) Free and fixed-ratio combinations of basal insulin and GLP-1 receptor agonists versus basal insulin intensification in type 2 diabetes: a systematic review and meta-analysis of randomized controlled trials. Diabetes Obes Metab 20(9):2309–2313. https://​doi.​org/​10.​1111/​dom.​13343CrossRefPubMed
216.
Zurück zum Zitat Blonde L, Rosenstock J, Del Prato S et al (2019) Switching to iGlarLixi versus continuing daily or weekly GLP-1 RA in type 2 diabetes inadequately controlled by GLP-1 RA and oral antihyperglycemic therapy: the LixiLan-G Randomized Clinical Trial. Diabetes Care 42(11):2108–2116. https://doi.org/10.2337/dc19-1357CrossRefPubMed Blonde L, Rosenstock J, Del Prato S et al (2019) Switching to iGlarLixi versus continuing daily or weekly GLP-1 RA in type 2 diabetes inadequately controlled by GLP-1 RA and oral antihyperglycemic therapy: the LixiLan-G Randomized Clinical Trial. Diabetes Care 42(11):2108–2116. https://​doi.​org/​10.​2337/​dc19-1357CrossRefPubMed
217.
218.
Zurück zum Zitat Aroda VR, Rosenstock J, Wysham C et al (2016) Efficacy and safety of LixiLan, a titratable fixed-ratio combination of insulin glargine plus lixisenatide in type 2 diabetes inadequately controlled on basal insulin and metformin: the LixiLan-L randomized trial. Diabetes Care 39(11):1972–1980. https://doi.org/10.2337/dc16-1495CrossRefPubMed Aroda VR, Rosenstock J, Wysham C et al (2016) Efficacy and safety of LixiLan, a titratable fixed-ratio combination of insulin glargine plus lixisenatide in type 2 diabetes inadequately controlled on basal insulin and metformin: the LixiLan-L randomized trial. Diabetes Care 39(11):1972–1980. https://​doi.​org/​10.​2337/​dc16-1495CrossRefPubMed
224.
226.
Zurück zum Zitat Matthews DR, Paldánius PM, Proot P et al (2019) Glycaemic durability of an early combination therapy with vildagliptin and metformin versus sequential metformin monotherapy in newly diagnosed type 2 diabetes (VERIFY): a 5-year, multicentre, randomised, double-blind trial. Lancet 394(10208):1519–1529. https://doi.org/10.1016/S0140-6736(19)32131-2 Matthews DR, Paldánius PM, Proot P et al (2019) Glycaemic durability of an early combination therapy with vildagliptin and metformin versus sequential metformin monotherapy in newly diagnosed type 2 diabetes (VERIFY): a 5-year, multicentre, randomised, double-blind trial. Lancet 394(10208):1519–1529. https://​doi.​org/​10.​1016/​S0140-6736(19)32131-2
227.
228.
Zurück zum Zitat Mantsiou C, Karagiannis T, Kakotrichi P et al (2020) Glucagon-like peptide-1 receptor agonists and sodium-glucose co-transporter-2 inhibitors as combination therapy for type 2 diabetes: a systematic review and meta-analysis. Diabetes Obes Metab 22(10):1857–1868. https://doi.org/10.1111/dom.14108CrossRefPubMed Mantsiou C, Karagiannis T, Kakotrichi P et al (2020) Glucagon-like peptide-1 receptor agonists and sodium-glucose co-transporter-2 inhibitors as combination therapy for type 2 diabetes: a systematic review and meta-analysis. Diabetes Obes Metab 22(10):1857–1868. https://​doi.​org/​10.​1111/​dom.​14108CrossRefPubMed
231.
234.
237.
238.
Zurück zum Zitat Min SH, Yoon JH, Hahn S, Cho YM (2018) Efficacy and safety of combination therapy with an α-glucosidase inhibitor and a dipeptidyl peptidase-4 inhibitor in patients with type 2 diabetes mellitus: a systematic review with meta-analysis. J Diabetes Investig 9(4):893–902. https://doi.org/10.1111/jdi.12754CrossRefPubMed Min SH, Yoon JH, Hahn S, Cho YM (2018) Efficacy and safety of combination therapy with an α-glucosidase inhibitor and a dipeptidyl peptidase-4 inhibitor in patients with type 2 diabetes mellitus: a systematic review with meta-analysis. J Diabetes Investig 9(4):893–902. https://​doi.​org/​10.​1111/​jdi.​12754CrossRefPubMed
249.
257.
Zurück zum Zitat Lavalle-Cobo A, Masson W, Lobo M, Masson G, Molinero G (2021) Glucagon-like peptide-1 receptor agonists and cardioprotective benefit in patients with type 2 diabetes without baseline metformin: a systematic review and update meta-analysis. High Blood Press Cardiovasc Prev 28(6):605–612. https://doi.org/10.1007/s40292-021-00479-1 Lavalle-Cobo A, Masson W, Lobo M, Masson G, Molinero G (2021) Glucagon-like peptide-1 receptor agonists and cardioprotective benefit in patients with type 2 diabetes without baseline metformin: a systematic review and update meta-analysis. High Blood Press Cardiovasc Prev 28(6):605–612. https://​doi.​org/​10.​1007/​s40292-021-00479-1
261.
270.
Zurück zum Zitat RISE Consortium (2019) Lack of Durable improvements in β-cell function following withdrawal of pharmacological interventions in adults with impaired glucose tolerance or recently diagnosed type 2 diabetes. Diabetes Care 42(9):1742–1751. https://doi.org/10.2337/dc19-0556CrossRef RISE Consortium (2019) Lack of Durable improvements in β-cell function following withdrawal of pharmacological interventions in adults with impaired glucose tolerance or recently diagnosed type 2 diabetes. Diabetes Care 42(9):1742–1751. https://​doi.​org/​10.​2337/​dc19-0556CrossRef
276.
284.
319.
322.
324.
Zurück zum Zitat Moses RG, Kalra S, Brook D et al (2014) A randomized controlled trial of the efficacy and safety of saxagliptin as add-on therapy in patients with type 2 diabetes and inadequate glycaemic control on metformin plus a sulphonylurea. Diabetes Obes Metab 16(5):443–450. https://doi.org/10.1111/dom.12234CrossRefPubMed Moses RG, Kalra S, Brook D et al (2014) A randomized controlled trial of the efficacy and safety of saxagliptin as add-on therapy in patients with type 2 diabetes and inadequate glycaemic control on metformin plus a sulphonylurea. Diabetes Obes Metab 16(5):443–450. https://​doi.​org/​10.​1111/​dom.​12234CrossRefPubMed
325.
329.
Zurück zum Zitat Nicolucci A, Ceriello A, Di Bartolo P, Corcos A, Orsini Federici M (2020) Rapid-acting insulin analogues versus regular human insulin: a meta-analysis of effects on glycemic control in patients with diabetes. Diabetes Ther 11(3):573–584. https://doi.org/10.1007/s13300-019-00732-w Nicolucci A, Ceriello A, Di Bartolo P, Corcos A, Orsini Federici M (2020) Rapid-acting insulin analogues versus regular human insulin: a meta-analysis of effects on glycemic control in patients with diabetes. Diabetes Ther 11(3):573–584. https://​doi.​org/​10.​1007/​s13300-019-00732-w
330.
Zurück zum Zitat Christiansen JS, Niskanen L, Rasmussen S, Johansen T, Fulcher G (2016) Lower rates of hypoglycemia during maintenance treatment with insulin degludec/insulin aspart versus biphasic insulin aspart 30: a combined analysis of two Phase 3a studies in type 2 diabetes. J Diabetes 8(5):720–728. https://doi.org/10.1111/1753-0407.12355CrossRefPubMed Christiansen JS, Niskanen L, Rasmussen S, Johansen T, Fulcher G (2016) Lower rates of hypoglycemia during maintenance treatment with insulin degludec/insulin aspart versus biphasic insulin aspart 30: a combined analysis of two Phase 3a studies in type 2 diabetes. J Diabetes 8(5):720–728. https://​doi.​org/​10.​1111/​1753-0407.​12355CrossRefPubMed
335.
Zurück zum Zitat Dicembrini I, Mannucci E, Monami M, Pala L (2019) Impact of technology on glycaemic control in type 2 diabetes: a meta-analysis of randomized trials on continuous glucose monitoring and continuous subcutaneous insulin infusion. Diabetes Obes Metab 21(12):2619–2625. https://doi.org/10.1111/dom.13845CrossRefPubMed Dicembrini I, Mannucci E, Monami M, Pala L (2019) Impact of technology on glycaemic control in type 2 diabetes: a meta-analysis of randomized trials on continuous glucose monitoring and continuous subcutaneous insulin infusion. Diabetes Obes Metab 21(12):2619–2625. https://​doi.​org/​10.​1111/​dom.​13845CrossRefPubMed
336.
Metadaten
Titel
Management of hyperglycaemia in type 2 diabetes, 2022. A consensus report by the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD)
verfasst von
Melanie J. Davies
Vanita R. Aroda
Billy S. Collins
Robert A. Gabbay
Jennifer Green
Nisa M. Maruthur
Sylvia E. Rosas
Stefano Del Prato
Chantal Mathieu
Geltrude Mingrone
Peter Rossing
Tsvetalina Tankova
Apostolos Tsapas
John B. Buse
Publikationsdatum
24.09.2022
Verlag
Springer Berlin Heidelberg
Erschienen in
Diabetologia / Ausgabe 12/2022
Print ISSN: 0012-186X
Elektronische ISSN: 1432-0428
DOI
https://doi.org/10.1007/s00125-022-05787-2

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Das größte medizinische Problem bei Tattoos bleiben allergische Reaktionen. Melanome werden dadurch offensichtlich nicht gefördert, die Farbpigmente könnten aber andere Tumoren begünstigen.

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