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11.04.2018 | Original Article

Prolapse reduction deteriorates the urethral closure mechanism

verfasst von: Yasmine Khayyami, Gunnar Lose, Niels Klarskov

Erschienen in: International Urogynecology Journal

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Abstract

Introduction and hypothesis

Pelvic organ prolapse (POP) reduction is often performed in the preoperative assessment of women before POP surgery. Using urethral pressure reflectometry (UPR), we sought to investigate how POP reduction affects the urethral closure mechanism.

Methods

Women with anterior or posterior vaginal wall prolapse stage ≥II with and without POP reduction were examined with a speculum. We performed prolapse staging according to the Pelvic Organ Prolapse Quantification system, UPR measurements at rest and during squeezing, and standardized stress tests with 300 ml saline. All examinations were repeated after insertion of a speculum.

Results

We included 38 women: 22 with anterior and 16 with posterior vaginal wall prolapse POP-Q stage  ≥II. During POP reduction, resting and squeezing urethral pressures decreased by 2.5 cmH2O (p = 0.007) and 5.1 cmH2O (p < 0.0001), respectively, in all women. During POP reduction, the number of positive stress tests increased from four (18%) to eight (36%) in women with anterior vaginal wall prolapse and from one (6%) to nine (56%) in women with posterior vaginal wall prolapse.

Conclusions

POP reduction decreases urethral pressure, especially during squeezing, and consequently increases the number of positive stress tests. The test itself artificially deteriorates the urethral closure mechanism.
Literatur
1.
Zurück zum Zitat Richardson DA, Bent AE, Ostergard DR. The effect of uterovaginal prolapse on urethrovesical pressure dynamics. Am J Obstet Gynecol. 1983;146:901–5.CrossRefPubMed Richardson DA, Bent AE, Ostergard DR. The effect of uterovaginal prolapse on urethrovesical pressure dynamics. Am J Obstet Gynecol. 1983;146:901–5.CrossRefPubMed
2.
Zurück zum Zitat Bergman A, Koonings PP, Ballard CA. Predicting postoperative urinary incontinence development in women undergoing operation for genitourinary prolapse. Am J Obstet Gynecol. 1988;158:1171–5.CrossRefPubMed Bergman A, Koonings PP, Ballard CA. Predicting postoperative urinary incontinence development in women undergoing operation for genitourinary prolapse. Am J Obstet Gynecol. 1988;158:1171–5.CrossRefPubMed
3.
Zurück zum Zitat Bump RC, Fantl JA, Hurt WG. The mechanism of urinary continence in women with severe uterovaginal prolapse: results of barrier studies. Obstet Gynecol. 1988;72:291–5.CrossRefPubMed Bump RC, Fantl JA, Hurt WG. The mechanism of urinary continence in women with severe uterovaginal prolapse: results of barrier studies. Obstet Gynecol. 1988;72:291–5.CrossRefPubMed
4.
Zurück zum Zitat Zivkovic F, Tamussino K, Haas J. Contribution of the posterior compartment to the urinary continence mechanism. Obstet Gynecol. 1998;91:229–33.CrossRefPubMed Zivkovic F, Tamussino K, Haas J. Contribution of the posterior compartment to the urinary continence mechanism. Obstet Gynecol. 1998;91:229–33.CrossRefPubMed
6.
Zurück zum Zitat Myers DL, Lasala CA, Hogan JW, Rosenblatt PL. The effect of posterior wall support defects on urodynamic indices in stress urinary incontinence. Obstet Gynecol. 1998;91:710–4.PubMed Myers DL, Lasala CA, Hogan JW, Rosenblatt PL. The effect of posterior wall support defects on urodynamic indices in stress urinary incontinence. Obstet Gynecol. 1998;91:710–4.PubMed
7.
Zurück zum Zitat Klarskov N. Urethral pressure reflectometry. A method for simultaneous measurements of pressure and cross-sectional area in the female urethra. Dan Med J. 2012;59:B4412.PubMed Klarskov N. Urethral pressure reflectometry. A method for simultaneous measurements of pressure and cross-sectional area in the female urethra. Dan Med J. 2012;59:B4412.PubMed
14.
Zurück zum Zitat Schäfer W. Some biomechanical aspects of continence function. Scand J Urol Nephrol Suppl. 2001;207:44–60. Schäfer W. Some biomechanical aspects of continence function. Scand J Urol Nephrol Suppl. 2001;207:44–60.
19.
Zurück zum Zitat Dumoulin C, Hay-Smith EJC, Mac Habée-Séguin G. Pelvic floor muscle training versus no treatment, or inactive control treatments, for urinary incontinence in women. Cochrane Database Syst Rev. 2014;5:CD005654 Dumoulin C, Hay-Smith EJC, Mac Habée-Séguin G. Pelvic floor muscle training versus no treatment, or inactive control treatments, for urinary incontinence in women. Cochrane Database Syst Rev. 2014;5:CD005654
21.
Zurück zum Zitat van der Ploeg J, Oude Rengerink K, van der Steen A, et al. Transvaginal prolapse repair with or without the addition of a midurethral sling in women with genital prolapse and stress urinary incontinence: a randomised trial. BJOG Int J Obstet Gynaecol. 2015;122:1022–30. https://doi.org/10.1111/1471-0528.13325.CrossRef van der Ploeg J, Oude Rengerink K, van der Steen A, et al. Transvaginal prolapse repair with or without the addition of a midurethral sling in women with genital prolapse and stress urinary incontinence: a randomised trial. BJOG Int J Obstet Gynaecol. 2015;122:1022–30. https://​doi.​org/​10.​1111/​1471-0528.​13325.CrossRef
22.
23.
Zurück zum Zitat Weber AM. Is urethral pressure profilometry a useful diagnostic test for stress urinary incontinence? Obstet Gynecol Surv. 2001;56:720–35.CrossRefPubMed Weber AM. Is urethral pressure profilometry a useful diagnostic test for stress urinary incontinence? Obstet Gynecol Surv. 2001;56:720–35.CrossRefPubMed
24.
Zurück zum Zitat Weber AM. Leak point pressure measurement and stress urinary incontinence. Curr Womens Health Rep. 2001;1:45–52.PubMed Weber AM. Leak point pressure measurement and stress urinary incontinence. Curr Womens Health Rep. 2001;1:45–52.PubMed
25.
Zurück zum Zitat Saaby M-L, Klarskov N, Lose G. Urethral pressure reflectometry during intra-abdominal pressure increase—an improved technique to characterize the urethral closure function in continent and stress urinary incontinent women. Neurourol Urodyn. 2013;32:1103–8. https://doi.org/10.1002/nau.22368.CrossRefPubMed Saaby M-L, Klarskov N, Lose G. Urethral pressure reflectometry during intra-abdominal pressure increase—an improved technique to characterize the urethral closure function in continent and stress urinary incontinent women. Neurourol Urodyn. 2013;32:1103–8. https://​doi.​org/​10.​1002/​nau.​22368.CrossRefPubMed
Metadaten
Titel
Prolapse reduction deteriorates the urethral closure mechanism
verfasst von
Yasmine Khayyami
Gunnar Lose
Niels Klarskov
Publikationsdatum
11.04.2018
Verlag
Springer International Publishing
Erschienen in
International Urogynecology Journal
Print ISSN: 0937-3462
Elektronische ISSN: 1433-3023
DOI
https://doi.org/10.1007/s00192-018-3647-x

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