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Erschienen in: Pediatric Radiology 7/2023

25.08.2022 | Improving Protocols

Microbubbles in the belly: optimizing the protocol for contrast-enhanced ultrasound of the pediatric abdomen

verfasst von: Lauramay Davis, Susan J. Back

Erschienen in: Pediatric Radiology | Ausgabe 7/2023

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Abstract

Intravenous contrast-enhanced ultrasound (CEUS) can serve as a diagnostic or problem-solving tool in pediatric imaging. CEUS of abdominal solid organs has been reported for a number of indications. The approach to the examination broadly falls into two categories: evaluation of a focal lesion or surveillance of an organ or organs for lesions or perfusion abnormalities. A consistent, technical imaging protocol for both of these clinical scenarios facilitates integration of routine use of CEUS in an imaging department. Here we review the CEUS imaging protocols for abdominal organs in children, including technical and solid-organ-specific considerations.
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Literatur
1.
Zurück zum Zitat Sridharan A, Eisenbrey JR, Forsberg F et al (2021) Ultrasound contrast agents: microbubbles made simple for the pediatric radiologist. Pediatr Radiol 51:2117–2127PubMedPubMedCentralCrossRef Sridharan A, Eisenbrey JR, Forsberg F et al (2021) Ultrasound contrast agents: microbubbles made simple for the pediatric radiologist. Pediatr Radiol 51:2117–2127PubMedPubMedCentralCrossRef
2.
Zurück zum Zitat Claudon M, Dietrich CF, Choi BI et al (2013) Guidelines and good clinical practice recommendations for contrast enhanced ultrasound (CEUS) in the liver — update 2012: a WFUMB-EFSUMB initiative in cooperation with representatives of AFSUMB, AIUM, ASUM, FLAUS and ICUS. Ultrasound Med Biol 39:187–210PubMedCrossRef Claudon M, Dietrich CF, Choi BI et al (2013) Guidelines and good clinical practice recommendations for contrast enhanced ultrasound (CEUS) in the liver — update 2012: a WFUMB-EFSUMB initiative in cooperation with representatives of AFSUMB, AIUM, ASUM, FLAUS and ICUS. Ultrasound Med Biol 39:187–210PubMedCrossRef
3.
Zurück zum Zitat Yusuf GT, Sellars ME, Deganello A et al (2017) Retrospective analysis of the safety and cost implications of pediatric contrast-enhanced ultrasound at a single center. AJR Am J Roentgenol 208:446–452PubMedCrossRef Yusuf GT, Sellars ME, Deganello A et al (2017) Retrospective analysis of the safety and cost implications of pediatric contrast-enhanced ultrasound at a single center. AJR Am J Roentgenol 208:446–452PubMedCrossRef
4.
Zurück zum Zitat Seelbach J, Kruger PC, Waginger M et al (2022) Safety and parents acceptance of ultrasound contrast agents in children and adolescents — contrast enhanced voiding urosonography and contrast enhanced ultrasound. Med Ultrason 24:27–32PubMedCrossRef Seelbach J, Kruger PC, Waginger M et al (2022) Safety and parents acceptance of ultrasound contrast agents in children and adolescents — contrast enhanced voiding urosonography and contrast enhanced ultrasound. Med Ultrason 24:27–32PubMedCrossRef
5.
Zurück zum Zitat Ntoulia A, Anupindi SA, Back SJ et al (2021) Contrast-enhanced ultrasound: a comprehensive review of safety in children. Pediatr Radiol 51:2161–2180PubMedCrossRef Ntoulia A, Anupindi SA, Back SJ et al (2021) Contrast-enhanced ultrasound: a comprehensive review of safety in children. Pediatr Radiol 51:2161–2180PubMedCrossRef
6.
Zurück zum Zitat Lindner JR, Belcik T, Main ML et al (2021) Expert consensus statement from the American Society of Echocardiography on hypersensitivity reactions to ultrasound enhancing agents in patients with allergy to polyethylene glycol. J Am Soc Echocardiogr 34:707–708PubMedPubMedCentralCrossRef Lindner JR, Belcik T, Main ML et al (2021) Expert consensus statement from the American Society of Echocardiography on hypersensitivity reactions to ultrasound enhancing agents in patients with allergy to polyethylene glycol. J Am Soc Echocardiogr 34:707–708PubMedPubMedCentralCrossRef
9.
Zurück zum Zitat Parker JM, Weller MW, Feinstein LM et al (2013) Safety of ultrasound contrast agents in patients with known or suspected cardiac shunts. Am J Cardiol 112:1039–1045PubMedCrossRef Parker JM, Weller MW, Feinstein LM et al (2013) Safety of ultrasound contrast agents in patients with known or suspected cardiac shunts. Am J Cardiol 112:1039–1045PubMedCrossRef
10.
Zurück zum Zitat Darge K, Back SJ, Bulas DI et al (2021) Pediatric contrast-enhanced ultrasound: shedding light on the pursuit of approval in the United States. Pediatr Radiol 51:2128–2138PubMedCrossRef Darge K, Back SJ, Bulas DI et al (2021) Pediatric contrast-enhanced ultrasound: shedding light on the pursuit of approval in the United States. Pediatr Radiol 51:2128–2138PubMedCrossRef
11.
Zurück zum Zitat Eisenbrey J, Greis C (2019) Ultrasound contrast agents: Lumason/SonoVue. In: Lyshchik A, Dietrich CF, Sidhu PS, Wilson SR (eds) Specialty imaging: fundamentals of CEUS. Elsevier, Philadelphia, pp 20–23 Eisenbrey J, Greis C (2019) Ultrasound contrast agents: Lumason/SonoVue. In: Lyshchik A, Dietrich CF, Sidhu PS, Wilson SR (eds) Specialty imaging: fundamentals of CEUS. Elsevier, Philadelphia, pp 20–23
12.
Zurück zum Zitat Eisenbrey J, Hilaire L, Warner G (2019) Ultrasound contrast agents: Definity. In: Lyshchik A, Dietrich CF, Sidhu PS, Wilson SR (eds) Specialty imaging: fundamentals of CEUS. Elsevier, Philadelphia, pp 24–27 Eisenbrey J, Hilaire L, Warner G (2019) Ultrasound contrast agents: Definity. In: Lyshchik A, Dietrich CF, Sidhu PS, Wilson SR (eds) Specialty imaging: fundamentals of CEUS. Elsevier, Philadelphia, pp 24–27
13.
Zurück zum Zitat Eisenbrey J (2019) Ultrasound contrast agents: Optison. In: Lyshchik A, Dietrich CF, Sidhu PS, Wilson SR (eds) Specialty imaging: fundamentals of CEUS. Elsevier, Philadelphia, pp 28–31 Eisenbrey J (2019) Ultrasound contrast agents: Optison. In: Lyshchik A, Dietrich CF, Sidhu PS, Wilson SR (eds) Specialty imaging: fundamentals of CEUS. Elsevier, Philadelphia, pp 28–31
14.
Zurück zum Zitat Greis C (2014) Technical aspects of contrast-enhanced ultrasound (CEUS) examinations: tips and tricks. Clin Hemorheol Microcirc 58:89–95PubMedCrossRef Greis C (2014) Technical aspects of contrast-enhanced ultrasound (CEUS) examinations: tips and tricks. Clin Hemorheol Microcirc 58:89–95PubMedCrossRef
15.
Zurück zum Zitat Hwang M, Back SJ, Didier RA et al (2021) Pediatric contrast-enhanced ultrasound: optimization of techniques and dosing. Pediatr Radiol 51:2147–2160PubMedCrossRef Hwang M, Back SJ, Didier RA et al (2021) Pediatric contrast-enhanced ultrasound: optimization of techniques and dosing. Pediatr Radiol 51:2147–2160PubMedCrossRef
16.
Zurück zum Zitat Eisenbrey JR, Daecher A, Kramer MR, Forsberg F (2015) Effects of needle and catheter size on commercially available ultrasound contrast agents. J Ultrasound Med 34:1961–1968PubMedCrossRef Eisenbrey JR, Daecher A, Kramer MR, Forsberg F (2015) Effects of needle and catheter size on commercially available ultrasound contrast agents. J Ultrasound Med 34:1961–1968PubMedCrossRef
17.
Zurück zum Zitat Talu E, Powell RL, Longo ML, Dayton PA (2008) Needle size and injection rate impact microbubble contrast agent population. Ultrasound Med Biol 34:1182–1185PubMedPubMedCentralCrossRef Talu E, Powell RL, Longo ML, Dayton PA (2008) Needle size and injection rate impact microbubble contrast agent population. Ultrasound Med Biol 34:1182–1185PubMedPubMedCentralCrossRef
18.
Zurück zum Zitat Kramer MR, Bhagat N, Forsberg F et al (2018) Influence of contrast-enhanced ultrasound administration setups on microbubble enhancement: a focus on pediatric applications. Pediatr Radiol 48:101–108PubMedCrossRef Kramer MR, Bhagat N, Forsberg F et al (2018) Influence of contrast-enhanced ultrasound administration setups on microbubble enhancement: a focus on pediatric applications. Pediatr Radiol 48:101–108PubMedCrossRef
22.
Zurück zum Zitat Armstrong LB, Mooney DP, Paltiel H et al (2018) Contrast enhanced ultrasound for the evaluation of blunt pediatric abdominal trauma. J Pediatr Surg 53:548–552PubMedCrossRef Armstrong LB, Mooney DP, Paltiel H et al (2018) Contrast enhanced ultrasound for the evaluation of blunt pediatric abdominal trauma. J Pediatr Surg 53:548–552PubMedCrossRef
23.
Zurück zum Zitat Coleman JL, Navid F, Furman WL, McCarville MB (2014) Safety of ultrasound contrast agents in the pediatric oncologic population: a single-institution experience. AJR Am J Roentgenol 202:966–970PubMedPubMedCentralCrossRef Coleman JL, Navid F, Furman WL, McCarville MB (2014) Safety of ultrasound contrast agents in the pediatric oncologic population: a single-institution experience. AJR Am J Roentgenol 202:966–970PubMedPubMedCentralCrossRef
24.
Zurück zum Zitat McCarville MB, Coleman JL, Guo J et al (2016) Use of quantitative dynamic contrast-enhanced ultrasound to assess response to antiangiogenic therapy in children and adolescents with solid malignancies: a pilot study. AJR Am J Roentgenol 206:933–939PubMedPubMedCentralCrossRef McCarville MB, Coleman JL, Guo J et al (2016) Use of quantitative dynamic contrast-enhanced ultrasound to assess response to antiangiogenic therapy in children and adolescents with solid malignancies: a pilot study. AJR Am J Roentgenol 206:933–939PubMedPubMedCentralCrossRef
25.
Zurück zum Zitat McMahon CJ, Ayres NA, Bezold LI et al (2005) Safety and efficacy of intravenous contrast imaging in pediatric echocardiography. Pediatr Cardiol 26:413–417PubMedCrossRef McMahon CJ, Ayres NA, Bezold LI et al (2005) Safety and efficacy of intravenous contrast imaging in pediatric echocardiography. Pediatr Cardiol 26:413–417PubMedCrossRef
26.
Zurück zum Zitat Bhayana D, Kim TK, Jang HJ et al (2010) Hypervascular liver masses on contrast-enhanced ultrasound: the importance of washout. AJR Am J Roentgenol 194:977–983PubMedCrossRef Bhayana D, Kim TK, Jang HJ et al (2010) Hypervascular liver masses on contrast-enhanced ultrasound: the importance of washout. AJR Am J Roentgenol 194:977–983PubMedCrossRef
27.
Zurück zum Zitat Heppner P, Ellegala DB, Durieux M et al (2006) Contrast ultrasonographic assessment of cerebral perfusion in patients undergoing decompressive craniectomy for traumatic brain injury. J Neurosurg 104:738–745PubMedCrossRef Heppner P, Ellegala DB, Durieux M et al (2006) Contrast ultrasonographic assessment of cerebral perfusion in patients undergoing decompressive craniectomy for traumatic brain injury. J Neurosurg 104:738–745PubMedCrossRef
28.
Zurück zum Zitat Lanka B, Jang H-J, Kim TK et al (2007) Impact of contrast-enhanced ultrasonography in a tertiary clinical practice. J Ultrasound Med 26:1703–1714PubMedCrossRef Lanka B, Jang H-J, Kim TK et al (2007) Impact of contrast-enhanced ultrasonography in a tertiary clinical practice. J Ultrasound Med 26:1703–1714PubMedCrossRef
29.
Zurück zum Zitat Fetzer DT, Rafailidis V, Peterson C et al (2018) Artifacts in contrast-enhanced ultrasound: a pictorial essay. Abdom Radiol 43:977–997CrossRef Fetzer DT, Rafailidis V, Peterson C et al (2018) Artifacts in contrast-enhanced ultrasound: a pictorial essay. Abdom Radiol 43:977–997CrossRef
30.
Zurück zum Zitat Sidhu PS, Cantisani V, Dietrich CF et al (2018) The EFSUMB guidelines and recommendations for the clinical practice of contrast-enhanced ultrasound (CEUS) in non-hepatic applications: update 2017 (long version). Ultraschall Med 39:e2–e44PubMedCrossRef Sidhu PS, Cantisani V, Dietrich CF et al (2018) The EFSUMB guidelines and recommendations for the clinical practice of contrast-enhanced ultrasound (CEUS) in non-hepatic applications: update 2017 (long version). Ultraschall Med 39:e2–e44PubMedCrossRef
31.
Zurück zum Zitat Greis C (2011) Quantitative evaluation of microvascular blood flow by contrast-enhanced ultrasound (CEUS). Clin Hemorheol Microcirc 49:137–149PubMedCrossRef Greis C (2011) Quantitative evaluation of microvascular blood flow by contrast-enhanced ultrasound (CEUS). Clin Hemorheol Microcirc 49:137–149PubMedCrossRef
32.
Zurück zum Zitat Ntoulia A, Barnewolt CE, Doria AS et al (2021) Contrast-enhanced ultrasound for musculoskeletal indications in children. Pediatr Radiol 51:2303–2323PubMedCrossRef Ntoulia A, Barnewolt CE, Doria AS et al (2021) Contrast-enhanced ultrasound for musculoskeletal indications in children. Pediatr Radiol 51:2303–2323PubMedCrossRef
34.
Zurück zum Zitat Paltiel HJ, Barth RA, Bruno C et al (2021) Contrast-enhanced ultrasound of blunt abdominal trauma in children. Pediatr Radiol 51:2253–2269PubMedCrossRef Paltiel HJ, Barth RA, Bruno C et al (2021) Contrast-enhanced ultrasound of blunt abdominal trauma in children. Pediatr Radiol 51:2253–2269PubMedCrossRef
35.
Zurück zum Zitat Franke D, Anupindi SA, Barnewolt CE et al (2021) Contrast-enhanced ultrasound of the spleen, pancreas and gallbladder in children. Pediatr Radiol 51:2229–2252PubMedCrossRef Franke D, Anupindi SA, Barnewolt CE et al (2021) Contrast-enhanced ultrasound of the spleen, pancreas and gallbladder in children. Pediatr Radiol 51:2229–2252PubMedCrossRef
36.
Zurück zum Zitat Fang C, Anupindi SA, Back SJ et al (2021) Contrast-enhanced ultrasound of benign and malignant liver lesions in children. Pediatr Radiol 51:2181–2197PubMedPubMedCentralCrossRef Fang C, Anupindi SA, Back SJ et al (2021) Contrast-enhanced ultrasound of benign and malignant liver lesions in children. Pediatr Radiol 51:2181–2197PubMedPubMedCentralCrossRef
37.
Zurück zum Zitat Back SJ, Acharya PT, Bellah RD et al (2021) Contrast-enhanced ultrasound of the kidneys and adrenals in children. Pediatr Radiol 51:2198–2213PubMedCrossRef Back SJ, Acharya PT, Bellah RD et al (2021) Contrast-enhanced ultrasound of the kidneys and adrenals in children. Pediatr Radiol 51:2198–2213PubMedCrossRef
38.
Zurück zum Zitat Sidhu PS, Cantisani V, Deganello A et al (2017) Role of contrast-enhanced ultrasound (CEUS) in paediatric practice: an EFSUMB position statement. Ultraschall Med 38:33–43PubMed Sidhu PS, Cantisani V, Deganello A et al (2017) Role of contrast-enhanced ultrasound (CEUS) in paediatric practice: an EFSUMB position statement. Ultraschall Med 38:33–43PubMed
39.
Zurück zum Zitat Dietrich CF, Augustiniene R, Batko T et al (2021) European Federation of Societies for Ultrasound in Medicine and Biology (EFSUMB): an update on the pediatric CEUS registry on behalf of the “EFSUMB Pediatric CEUS Registry Working Group.” Ultraschall Med 42:270–277 Dietrich CF, Augustiniene R, Batko T et al (2021) European Federation of Societies for Ultrasound in Medicine and Biology (EFSUMB): an update on the pediatric CEUS registry on behalf of the “EFSUMB Pediatric CEUS Registry Working Group.” Ultraschall Med 42:270–277
40.
Zurück zum Zitat Dietrich CF, Nolsoe CP, Barr RG et al (2020) Guidelines and good clinical practice recommendations for contrast enhanced ultrasound (CEUS) in the liver — update 2020 WFUMB in cooperation with EFSUMB, AFSUMB, AIUM, and FLAUS. Ultraschall Med 41:562–585PubMedCrossRef Dietrich CF, Nolsoe CP, Barr RG et al (2020) Guidelines and good clinical practice recommendations for contrast enhanced ultrasound (CEUS) in the liver — update 2020 WFUMB in cooperation with EFSUMB, AFSUMB, AIUM, and FLAUS. Ultraschall Med 41:562–585PubMedCrossRef
41.
Zurück zum Zitat Wilson SR, Lyshchik A, Piscaglia F et al (2018) CEUS LI-RADS: algorithm, implementation, and key differences from CT/MRI. Abdom Radiol 43:127–142CrossRef Wilson SR, Lyshchik A, Piscaglia F et al (2018) CEUS LI-RADS: algorithm, implementation, and key differences from CT/MRI. Abdom Radiol 43:127–142CrossRef
42.
Zurück zum Zitat Shang J, Wang YY, Dang Y et al (2017) An inflammatory myofibroblastic tumor in the transplanted liver displaying quick wash-in and wash-out on contrast-enhanced ultrasound: a case report. Medicine 96:e9024PubMedPubMedCentralCrossRef Shang J, Wang YY, Dang Y et al (2017) An inflammatory myofibroblastic tumor in the transplanted liver displaying quick wash-in and wash-out on contrast-enhanced ultrasound: a case report. Medicine 96:e9024PubMedPubMedCentralCrossRef
43.
Zurück zum Zitat El-Ali AM, McCormick A, Thakrar D et al (2020) Contrast-enhanced ultrasound of congenital and infantile hemangiomas: preliminary results from a case series. AJR Am J Roentgenol 214:658–664PubMedCrossRef El-Ali AM, McCormick A, Thakrar D et al (2020) Contrast-enhanced ultrasound of congenital and infantile hemangiomas: preliminary results from a case series. AJR Am J Roentgenol 214:658–664PubMedCrossRef
44.
Zurück zum Zitat Yang HK, Burns PN, Jang HJ et al (2019) Contrast-enhanced ultrasound approach to the diagnosis of focal liver lesions: the importance of washout. Ultrasonography 38:289–301PubMedPubMedCentralCrossRef Yang HK, Burns PN, Jang HJ et al (2019) Contrast-enhanced ultrasound approach to the diagnosis of focal liver lesions: the importance of washout. Ultrasonography 38:289–301PubMedPubMedCentralCrossRef
45.
Zurück zum Zitat Catalano O, Sandomenico F, Vallone P et al (2006) Contrast-enhanced sonography of the spleen. Semin Ultrasound CT MR 27:426–433PubMedCrossRef Catalano O, Sandomenico F, Vallone P et al (2006) Contrast-enhanced sonography of the spleen. Semin Ultrasound CT MR 27:426–433PubMedCrossRef
46.
Zurück zum Zitat Hains DS, Cohen HL, McCarville MB et al (2017) Elucidation of renal scars in children with vesicoureteral reflux using contrast enhanced ultrasound: a pilot study. Kidney Int Rep 2:420–424PubMedPubMedCentralCrossRef Hains DS, Cohen HL, McCarville MB et al (2017) Elucidation of renal scars in children with vesicoureteral reflux using contrast enhanced ultrasound: a pilot study. Kidney Int Rep 2:420–424PubMedPubMedCentralCrossRef
47.
Zurück zum Zitat Kapur J, Oscar H (2015) Contrast-enhanced ultrasound of kidneys in children with renal failure. J Med Ultrasound 23:86–97CrossRef Kapur J, Oscar H (2015) Contrast-enhanced ultrasound of kidneys in children with renal failure. J Med Ultrasound 23:86–97CrossRef
48.
Zurück zum Zitat Fontanilla T, Minaya J, Cortes C et al (2012) Acute complicated pyelonephritis: contrast-enhanced ultrasound. Abdom Imaging 37:639–646PubMedCrossRef Fontanilla T, Minaya J, Cortes C et al (2012) Acute complicated pyelonephritis: contrast-enhanced ultrasound. Abdom Imaging 37:639–646PubMedCrossRef
49.
Zurück zum Zitat Bertolotto M, Cicero C, Catalano O et al (2018) Solid renal tumors isoenhancing to kidneys on contrast-enhanced sonography: differentiation from pseudomasses. J Ultrasound Med 37:233–242PubMedCrossRef Bertolotto M, Cicero C, Catalano O et al (2018) Solid renal tumors isoenhancing to kidneys on contrast-enhanced sonography: differentiation from pseudomasses. J Ultrasound Med 37:233–242PubMedCrossRef
Metadaten
Titel
Microbubbles in the belly: optimizing the protocol for contrast-enhanced ultrasound of the pediatric abdomen
verfasst von
Lauramay Davis
Susan J. Back
Publikationsdatum
25.08.2022
Verlag
Springer Berlin Heidelberg
Erschienen in
Pediatric Radiology / Ausgabe 7/2023
Print ISSN: 0301-0449
Elektronische ISSN: 1432-1998
DOI
https://doi.org/10.1007/s00247-022-05464-x

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