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European Journal of Nuclear Medicine and Molecular Imaging

Erschienen in:

01.12.2007 | Original article

The impact of ¹⁸F-FDG PET/CT in patients with liver metastases

verfasst von: Siew C. Chua, Ashley M. Groves, Irfan Kayani, Leon Menezes, Svetislav Gacinovic, Yong Du, Jamshed B. Bomanji, Peter J. Ell

Erschienen in: European Journal of Nuclear Medicine and Molecular Imaging | Ausgabe 12/2007

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Abstract

Purpose

The aim of this study was to assess the performance of ¹⁸F-fluorodeoxyglucose positron emission tomography/computed tomography (¹⁸F-FDG PET/CT) versus dedicated contrast-enhanced CT (CECT) in the detection of metastatic liver disease.

Methods

All patients that presented to our Institution with suspected metastatic liver disease who underwent ¹⁸F-FDG PET/CT and CECT within 6 weeks of each other, were retrospectively analyzed, covering a 5-year period. One hundred and thirty-one patients (67 men, 64 women; mean age 62) were identified. Seventy-five had colorectal carcinoma and 56 had other malignancies. The performance of CECT and that of ¹⁸F-FDG-PET/CT in detecting liver metastases were compared. The ability of each to detect local recurrence, extrahepatic metastases and to alter patient management was recorded. The final diagnosis was based on histology, clinical and radiological follow-up (mean 23 months).

Results

In detecting hepatic metastases, ¹⁸F-FDG-PET/CT yielded 96% sensitivity and 75% specificity, whilst CECT showed 88% sensitivity and 25% specificity. ¹⁸F-FDG-PET/CT and CECT were concordant in 102 out of 131 patients (78%). In the colorectal group ¹⁸F-FDG-PET/CT showed 94% sensitivity and 75% specificity, whilst CECT had 91% sensitivity and 25% specificity. In the noncolorectal group ¹⁸F-FDG-PET/CT showed 98% sensitivity and 75% specificity whilst CECT had 85% sensitivity and 25% specificity. Overall, ¹⁸F-FDG-PET/CT altered patient management over CECT in 25% of patients. CECT did not alter patient management over ¹⁸F-FDG-PET/CT alone in any patients.

Conclusion

¹⁸F-FDG-PET/CT performed better in detecting metastatic liver disease than CECT in both colorectal and noncolorectal malignancies, and frequently altered patient management. The future role of CECT in these patients may need to be re-evaluated to avoid potentially unnecessary duplication of investigation where ¹⁸F-PET/CT is readily available.

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Titel: The impact of 18F-FDG PET/CT in patients with liver metastases
verfasst von: Siew C. Chua
Ashley M. Groves
Irfan Kayani
Leon Menezes
Svetislav Gacinovic
Yong Du
Jamshed B. Bomanji
Peter J. Ell
Publikationsdatum: 01.12.2007
Verlag: Springer-Verlag
Erschienen in: European Journal of Nuclear Medicine and Molecular Imaging / Ausgabe 12/2007
Print ISSN: 1619-7070
Elektronische ISSN: 1619-7089
DOI: https://doi.org/10.1007/s00259-007-0518-y

Die Highlights vom Kongress des American College of Cardiology 2024

Springer Medizin

The impact of ¹⁸F-FDG PET/CT in patients with liver metastases

Abstract

Purpose

Methods

Results

Conclusion

Die Highlights vom Kongress des American College of Cardiology 2024

Springer Medizin

Abstract

Purpose

Methods

Results

Conclusion

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