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European Journal of Nuclear Medicine and Molecular Imaging

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01.10.2014 | Original Article

Diagnostic value of FDG-PET/(CT) in children with fever of unknown origin and unexplained fever during immune suppression

verfasst von: Gijsbert J. Blokhuis, Chantal P. Bleeker-Rovers, Marije G. Diender, Wim J. G. Oyen, Jos M. Th. Draaisma, Lioe-Fee de Geus-Oei

Erschienen in: European Journal of Nuclear Medicine and Molecular Imaging | Ausgabe 10/2014

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Abstract

Purpose

Fever of unknown origin (FUO) and unexplained fever during immune suppression in children are challenging medical problems. The aim of this study is to investigate the diagnostic value of fluorine-18 fluorodeoxyglucose positron emission tomography (FDG-PET) and FDG-PET combined with computed tomography (FDG-PET/CT) in children with FUO and in children with unexplained fever during immune suppression.

Methods

All FDG-PET/(CT) scans performed in the Radboud university medical center for the evaluation of FUO or unexplained fever during immune suppression in the last 10 years were reviewed. Results were compared with the final clinical diagnosis.

Results

FDG-PET/(CT) scans were performed in 31 children with FUO. A final diagnosis was established in 16 cases (52 %). Of the total number of scans, 32 % were clinically helpful. The sensitivity and specificity of FDG-PET/CT in these patients was 80 % and 78 %, respectively. FDG-PET/(CT) scans were performed in 12 children with unexplained fever during immune suppression. A final diagnosis was established in nine patients (75 %). Of the total number of these scans, 58 % were clinically helpful. The sensitivity and specificity of FDG-PET/CT in children with unexplained fever during immune suppression was 78 % and 67 %, respectively.

Conclusions

FDG-PET/CT appears a valuable imaging technique in the evaluation of children with FUO and in the diagnostic process of children with unexplained fever during immune suppression. Prospective studies of FDG-PET/CT as part of a structured diagnostic protocol are warranted to assess the additional diagnostic value.

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Titel: Diagnostic value of FDG-PET/(CT) in children with fever of unknown origin and unexplained fever during immune suppression
verfasst von: Gijsbert J. Blokhuis
Chantal P. Bleeker-Rovers
Marije G. Diender
Wim J. G. Oyen
Jos M. Th. Draaisma
Lioe-Fee de Geus-Oei
Publikationsdatum: 01.10.2014
Verlag: Springer Berlin Heidelberg
Erschienen in: European Journal of Nuclear Medicine and Molecular Imaging / Ausgabe 10/2014
Print ISSN: 1619-7070
Elektronische ISSN: 1619-7089
DOI: https://doi.org/10.1007/s00259-014-2801-z

Die Highlights vom Kongress des American College of Cardiology 2024

Springer Medizin

Diagnostic value of FDG-PET/(CT) in children with fever of unknown origin and unexplained fever during immune suppression

Abstract

Purpose

Methods

Results

Conclusions

Die Highlights vom Kongress des American College of Cardiology 2024

Springer Medizin

Abstract

Purpose

Methods

Results

Conclusions

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