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01.03.2015 | Original Article

Anxiety and depressive disorders among patients with esophageal cancer in Taiwan: a nationwide population-based study

verfasst von: Li-Yu Hu, Fan-Chen Ku, Yen-Po Wang, Cheng-Che Shen, Yu-Wen Hu, Chiu-Mei Yeh, Pan-Ming Chen, Huey-Ling Chiang, Ti Lu, Tzeng-Ji Chen, Chung-Jen Teng, Chia-Jen Liu

Erschienen in: Supportive Care in Cancer | Ausgabe 3/2015

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Abstract

Background

The comorbidity of depression with anxiety disorders is associated with poorer treatment outcomes, worse quality of life, poorer adherence to treatment, and greater suicide risk in cancer patients.

Objective

To assess the risk of comorbid anxiety and depressive disorders after the diagnosis of esophageal cancer compared with a matched cohort by using the Taiwan National Health Insurance Research Database (NHIRD).

Methods

We conducted a retrospective study of 28,454 patients (14,227 patients with esophageal cancer and 14,227 matched patients) who were selected from the NHIRD. Patients were observed for a maximum of 12 years to determine the incidence of new-onset anxiety and depressive disorders for which antidepressants had been prescribed. A Cox regression analysis was performed to identify the risk factors associated with anxiety and depressive disorders in esophageal cancer patients.

Results

The cumulative incidence of anxiety and depressive disorders in the esophageal cancer patients was significantly higher than that in the matched cohort (P < .001). The adjusted hazard ratio (HR) was 2.24 (95 % confidence interval, CI = 1.95–2.56, P < .001) in the esophageal cancer cohort compared with the matched cohort. Independent risk factors for developing anxiety and depressive disorders among the patients with esophageal cancer included cirrhosis, cerebrovascular disease, and surgical treatment.

Conclusion

Esophageal cancer may be a prominent risk factor for anxiety and depressive disorders. Based on our data, we suggest that attention should be focused on esophageal cancer patients with comorbid cirrhosis and cerebrovascular disease and those who have received surgical interventions.

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Titel: Anxiety and depressive disorders among patients with esophageal cancer in Taiwan: a nationwide population-based study
verfasst von: Li-Yu Hu
Fan-Chen Ku
Yen-Po Wang
Cheng-Che Shen
Yu-Wen Hu
Chiu-Mei Yeh
Pan-Ming Chen
Huey-Ling Chiang
Ti Lu
Tzeng-Ji Chen
Chung-Jen Teng
Chia-Jen Liu
Publikationsdatum: 01.03.2015
Verlag: Springer Berlin Heidelberg
Erschienen in: Supportive Care in Cancer / Ausgabe 3/2015
Print ISSN: 0941-4355
Elektronische ISSN: 1433-7339
DOI: https://doi.org/10.1007/s00520-014-2403-0

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Anxiety and depressive disorders among patients with esophageal cancer in Taiwan: a nationwide population-based study