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04.06.2020 | Original Article

Feasibility study for evaluating lumbar intervertebral disc degeneration using histogram analysis of T2* values

verfasst von: Xiaoqing Liang, Ruyi Xie, Bowen Hou, Yitong Li, Yan Xiong, Cuilin Yin, Weiyin Vivian Liu, John Morelli, Xiaoming Li

Erschienen in: European Spine Journal | Ausgabe 10/2020

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Abstract

Purpose

To evaluate the feasibility of histogram analysis of T2* value for the detection and grading of degenerative lumbar intervertebral discs (IVDs) and for the characterization of microstructural heterogeneity of discs.

Methods

Two hundred fourteen lumbar IVDs of 44 subjects with chronic low back pain were examined using sagittal T2WI and axial T2* mapping. All IVDs were classified according to the Pfirrmann grade on T2WI. The correlations between histogram-derived parameters based on T2* values (T2*-HPs) of IVDs and Pfirrmann grade as well as between “red zone ratio” (area of “red zone” on T2* color maps over cross-sectional area of corresponding IVDs) and Pfirrmann grade were calculated.

Results

The agreement for Pfirrmann grade of IVDs was excellent (κ = 0.808, P < 0.001). The consistency of the measured T2*-HPs was excellent, with ICCs ranging from 0.828–0.960. Each histogram-derived parameter had a statistically significant relationship with Pfirrmann grade (P < 0.001). The bright “red zone” on T2* color maps of IVDs displayed as a separated peak relative to the rest of voxels in histograms. The mean area ratio of “red zone” over the corresponding IVD was 9.234% ± 6.680 and ranged from 0.517% to 30.598%. The “red zone ratio” was highly related to Pfirrmann grade (r = − 0.732, P < 0.001).

Conclusion

Histogram analysis of T2* value is an effective tool for the detection and grading of degenerative IVDs. Identification of the “red zone” may provide new breakthroughs in the study of disc degeneration initiation and generate new hypotheses in anatomical and histological studies of IVDs.

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Titel: Feasibility study for evaluating lumbar intervertebral disc degeneration using histogram analysis of T2* values
verfasst von: Xiaoqing Liang
Ruyi Xie
Bowen Hou
Yitong Li
Yan Xiong
Cuilin Yin
Weiyin Vivian Liu
John Morelli
Xiaoming Li
Publikationsdatum: 04.06.2020
Verlag: Springer Berlin Heidelberg
Erschienen in: European Spine Journal / Ausgabe 10/2020
Print ISSN: 0940-6719
Elektronische ISSN: 1432-0932
DOI: https://doi.org/10.1007/s00586-020-06476-7

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Feasibility study for evaluating lumbar intervertebral disc degeneration using histogram analysis of T2* values