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01.01.2013 | Original Article

Frequent detection and characterization of hepatitis E virus variants in wild rats (Rattus rattus) in Indonesia

verfasst von: Mulyanto, Sulaiman Ngongu Depamede, Made Sriasih, Masaharu Takahashi, Shigeo Nagashima, Suljid Jirintai, Tsutomu Nishizawa, Hiroaki Okamoto

Erschienen in: Archives of Virology | Ausgabe 1/2013

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Abstract

One hundred sixteen rats (Rattus rattus) captured in Indonesia from 2011 to 2012 were investigated for the prevalence of hepatitis E virus (HEV)-specific antibodies and HEV RNA. Using an ELISA based on HEV genotype 4 with an ad hoc cutoff value of 0.500, 18.1 % of the rats tested positive for anti-HEV IgG. By nested RT-PCR, 14.7 % of the rats had rat HEV RNA, and none were positive for HEV genotype 1-4. A high HEV prevalence among rats was associated with lower sanitary conditions in areas with a high population density. Sixteen of the 17 HEV isolates obtained from infected rats showed >93.0 % nucleotide sequence identity within the 840-nucleotide ORF1-ORF2 sequence and were most closely related to a Vietnamese strain (85.9-87.9 % identity), while the remaining isolate differed from known rat HEV strains by 18.8-23.3 % and may belong to a novel lineage of rat HEV. These results suggest a wide distribution of rat HEV with divergent genomes.

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Titel: Frequent detection and characterization of hepatitis E virus variants in wild rats (Rattus rattus) in Indonesia
verfasst von: Mulyanto
Sulaiman Ngongu Depamede
Made Sriasih
Masaharu Takahashi
Shigeo Nagashima
Suljid Jirintai
Tsutomu Nishizawa
Hiroaki Okamoto
Publikationsdatum: 01.01.2013
Verlag: Springer Vienna
Erschienen in: Archives of Virology / Ausgabe 1/2013
Print ISSN: 0304-8608
Elektronische ISSN: 1432-8798
DOI: https://doi.org/10.1007/s00705-012-1462-0

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