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08.08.2020 | Review

Koala retrovirus epidemiology, transmission mode, pathogenesis, and host immune response in koalas (Phascolarctos cinereus): a review

verfasst von: Mohammad Enamul Hoque Kayesh, Md Abul Hashem, Kyoko Tsukiyama-Kohara

Erschienen in: Archives of Virology | Ausgabe 11/2020

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Abstract

Koala retrovirus (KoRV) is a major threat to koala health and conservation. It also represents a series of challenges across the fields of virology, immunology, and epidemiology that are of great potential interest to any researcher in the field of retroviral diseases. KoRV is a gammaretrovirus that is present in both endogenous and exogenous forms in koala populations, with a still-active endogenization process. KoRV may induce immunosuppression and neoplastic conditions such as lymphoma and leukemia and play a role in chlamydiosis and other diseases in koalas. KoRV transmission modes, pathogenesis, and host immune response still remain unclear, and a clear understanding of these areas is critical for devising effective preventative and therapeutic strategies. Research on KoRV is clearly critical for koala conservation. In this review, we provide an overview of the current understanding and future challenges related to KoRV epidemiology, transmission mode, pathogenesis, and host immune response and discuss prospects for therapeutic and preventive vaccines.

Canfield PJ, Sabine JM, Love DN (1988) Virus particles associated with leukaemia in a koala. Aust Vet J 65:327–328PubMed

Hanger JJ, Bromham LD, McKee JJ, O’Brien TM, Robinson WF (2000) The nucleotide sequence of Koala (Phascolarctos cinereus) retrovirus: a novel type C endogenous virus related to Gibbon ape leukemia virus. J Virol 74:4264–4272PubMedPubMedCentral

Denner J, Young PR (2013) Koala retroviruses: characterization and impact on the life of koalas. Retrovirology 10:108PubMedPubMedCentral

Tarlinton R, Meers J, Hanger J, Young P (2005) Real-time reverse transcriptase PCR for the endogenous koala retrovirus reveals an association between plasma viral load and neoplastic disease in koalas. J Gen Virol 86:783–787PubMed

Tarlinton RE, Meers J, Young PR (2006) Retroviral invasion of the koala genome. Nature 442:79–81PubMed

Fiebig U, Hartmann MG, Bannert N, Kurth R, Denner J (2006) Transspecies transmission of the endogenous koala retrovirus. J Virol 80:5651–5654PubMedPubMedCentral

Xu W, Stadler CK, Gorman K et al (2013) An exogenous retrovirus isolated from koalas with malignant neoplasias in a US zoo. Proc Natl Acad Sci USA 110:11547–11552PubMedPubMedCentral

Waugh CA, Hanger J, Loader J, King A, Hobbs M, Johnson R, Timms P (2017) Infection with koala retrovirus subgroup B (KoRV-B), but not KoRV-A, is associated with chlamydial disease in free-ranging koalas (Phascolarctos cinereus). Sci Rep 7:134PubMedPubMedCentral

Quigley BL, Ong VA, Hanger J, Timms P (2018) Molecular dynamics and mode of transmission of koala retrovirus as it invades and spreads through a wild Queensland koala population. J Virol 92:e01871–e1917PubMedPubMedCentral

10.

Maher IE, Patterson J, Curnick M, Devlin J, Higgins DP (2019) Altered immune parameters associated with koala retrovirus (KoRV) and chlamydial infection in free ranging Victorian koalas (Phascolarctos cinereus). Sci Rep 9:11170PubMedPubMedCentral

11.

Ishida Y, Zhao K, Greenwood AD, Roca AL (2015) Proliferation of endogenous retroviruses in the early stages of a host germ line invasion. Mol Biol Evol 32:109–120PubMed

12.

Gifford R, Tristem M (2003) The evolution, distribution and diversity of endogenous retroviruses. Virus Genes 26:291–315PubMed

13.

Simmons GS, Young PR, Hanger JJ, Jones K, Clarke D, McKee JJ, Meers J (2012) Prevalence of koala retrovirus in geographically diverse populations in Australia. Aust Vet J 90:404–409PubMed

14.

Shojima T, Yoshikawa R, Hoshino S et al (2013) Identification of a novel subgroup of koala retrovirus from koalas in Japanese Zoos. J Virol 87:9943–9946PubMedPubMedCentral

15.

Hobbs M, King A, Salinas R et al (2017) Long-read genome sequence assembly provides insight into ongoing retroviral invasion of the koala germline. Sci Rep 7:15838PubMedPubMedCentral

16.

Hashem MA, Maetani F, Kayesh MEH et al (2020) Transmission of koala retrovirus from parent koalas to a joey in a Japanese zoo. J Virol 94:e00019–20PubMedPubMedCentral

17.

Quigley BL, Phillips S, Olagoke O, Robbins A, Hanger J, Timms P (2019) Changes in endogenous and exogenous koala retrovirus (KoRV) subtype expression over time reflects koala health outcomes. J Virol 93:e00849–e919PubMedPubMedCentral

18.

Chappell KJ, Brealey JC, Amarilla AA et al (2017) Phylogenetic diversity of koala retrovirus within a wild koala population. J Virol 91:e01820–e1916PubMedPubMedCentral

19.

Shimode S, Nakagawa S, Yoshikawa R, Shojima T, Miyazawa T (2014) Heterogeneity of koala retrovirus isolates. FEBS Lett 588:41–46PubMed

20.

Oliveira NM, Farrell KB, Eiden MV (2006) In vitro characterization of a koala retrovirus. J Virol 80:3104–3107PubMedPubMedCentral

21.

Löber U, Hobbs M, Dayaram A et al (2018) Degradation and remobilization of endogenous retroviruses by recombination during the earliest stages of a germ-line invasion. Proc Natl Acad Sci USA 115:8609–8614PubMedPubMedCentral

22.

Johnson RN, O’Meally D, Chen Z et al (2018) Adaptation and conservation insights from the koala genome. Nat Genet 50:1102–1111PubMedPubMedCentral

23.

Kayesh MEH, Yamato O, Rahman MM et al (2019) Molecular dynamics of koala retrovirus infection in captive koalas in Japan. Arch Virol 164:757–765PubMed

24.

Hashem MA, Kayesh MEH, Yamato O et al (2019) Coinfection with koala retrovirus subtypes A and B and its impact on captive koalas in Japanese zoos. Arch Virol 164:2735–2745PubMed

25.

Sarker N, Fabijan J, Owen H et al (2020) Koala retrovirus viral load and disease burden in distinct northern and southern koala populations. Sci Rep 10:263PubMedPubMedCentral

26.

Bock M, Stoye JP (2000) Endogenous retroviruses and the human germline. Curr Opin Genet Dev 10:651–655PubMed

27.

Boeke JD, Stoye JP (1997) Retrotransposons, endogenous retroviruses, and the evolution of retroelements. In: Coffin JM, Hughes SH, Varmus HE (eds) Retroviruses. Cold Spring Harbor, Cold Spring Harbor Laboratory, New York, pp 343–346

28.

Tsang J, Ribet D, Heidmann T, Dewannieux M (2019) Identification of the receptor used by the ecotropic mouse GLN endogenous retrovirus. J Virol 93:e01125–e1218PubMedPubMedCentral

29.

Shojima T, Hoshino S, Abe M, Yasuda J, Shogen H, Kobayashi T, Miyazawa T (2013) Construction and characterization of an infectious molecular clone of koala retrovirus. J Virol 87:5081–5088PubMedPubMedCentral

30.

Waugh C, Gillett A, Polkinghorne A, Timms P (2016) Serum antibody response to koala retrovirus antigens varies in free-ranging koalas (Phascolarctos cinereus) in Australia: implications for vaccine design. J Wildl Dis 52:422–425PubMed

31.

Miyazawa T, Shojima T, Yoshikawa R, Ohata T (2011) Isolation of koala retroviruses from koalas in Japan. J Vet Med Sci 73:65–70PubMed

32.

Fiebig U, Keller M, Denner J (2016) Detection of koala retrovirus subgroup B (KoRV-B) in animals housed at European zoos. Arch Virol 161:3549–3553PubMed

33.

Fabijan J, Miller D, Olagoke O et al (2019) Prevalence and clinical significance of koala retrovirus in two South Australian koala (Phascolarctos cinereus) populations. J Med Microbiol 68:1072–1080PubMed

34.

Legione AR, Patterson JLS, Whiteley P et al (2017) Koala retrovirus genotyping analyses reveal a low prevalence of KoRV-A in Victorian koalas and an association with clinical disease. J Med Microbiol 66:236–244PubMed

35.

Sarker N, Fabijan J, Seddon J et al (2019) Genetic diversity of Koala retrovirus env gene subtypes: insights into northern and southern koala populations. J Gen Virol 100:1328–1339PubMed

36.

Gao F, Yue L, Robertson DL et al (1994) Genetic diversity of human immunodeficiency virus type 2: evidence for distinct sequence subtypes with differences in virus biology. J Virol 68:7433–7447PubMedPubMedCentral

37.

Gao F, Bailes E, Robertson DL et al (1999) Origin of HIV-1 in the chimpanzee Pan troglodytes troglodytes. Nature 397:436–441PubMed

38.

Simmons G, Clarke D, McKee J, Young P, Meers J (2014) Discovery of a novel retrovirus sequence in an Australian native rodent (Melomys burtoni): a putative link between gibbon ape leukemia virus and koala retrovirus. PLoS ONE 9:e106954PubMedPubMedCentral

39.

Alfano N, Michaux J, Morand S et al (2016) Endogenous gibbon ape leukemia virus identified in a rodent (Melomys burtoni subsp.) from Wallacea (Indonesia). J Virol 90:8169–8180PubMedPubMedCentral

40.

Hayward JA, Tachedjian M, Kohl C et al (2020) Infectious KoRV-related retroviruses circulating in Australian bats. Proc Natl Acad Sci USA 117:9529–9536PubMedPubMedCentral

41.

Xu W, Eiden MV (2015) Koala retroviruses: evolution and disease dynamics. Annu Rev Virol 2:119–134PubMed

42.

Tsangaras K, Siracusa MC, Nikolaidis N et al (2014) Hybridization capture reveals evolution and conservation across the entire koala retrovirus genome. PLoS ONE 9:e95633PubMedPubMedCentral

43.

Cui P, Löber U, Alquezar-Planas DE et al (2016) Comprehensive profiling of retroviral integration sites using target enrichment methods from historical koala samples without an assembled reference genome. PeerJ 4:e1847PubMedPubMedCentral

44.

Bendinelli M, Matteucci D, Friedman H (1985) Retrovirus-induced acquired immunodeficiencies. Adv Cancer Res 45:125–181PubMed

45.

Bishop JM (1987) The molecular genetics of cancer. Science 235:305–311PubMed

46.

Rosenberg N, Jolicoeur P (1997) Retroviral pathogenesis. In : Coffin JM et al (eds) Retroviruses. Cold Spring Harbour Laboratory Press

47.

Tarlinton R, Meers J, Young P (2008) Biology and evolution of the endogenous koala retrovirus. Cell Mol Life Sci 65:3413–3421PubMed

48.

Fabijan J, Sarker N, Speight N et al (2020) Pathological findings in koala retrovirus-positive Koalas (Phascolarctos cinereus) from northern and southern Australia. J Comp Pathol 176:50–66PubMed

49.

Butcher RG, Pettett LM, Fabijan J et al (2020) Periodontal disease in free-ranging koalas (Phascolarctos cinereus) from the Mount Lofty Ranges, South Australia, and its association with koala retrovirus infection. Aust Vet J 98:200–206PubMed

50.

Fabijan J, Woolford L, Lathe S, Simmons G, Hemmatzadeh F, Trott DJ, Speight KN (2017) Lymphoma, koala retrovirus infection and reproductive chlamydiosis in a koala (Phascolarctos cinereus). J Comp Pathol 157:188–192PubMed

51.

Carey AJ, Timms P, Rawlinson G, Brumm J, Nilsson K, Harris JM, Beagley KW (2010) A multi-subunit chlamydial vaccine induces antibody and cell-mediated immunity in immunized koalas (Phascolarctos cinereus): comparison of three different adjuvants. Am J Reprod Immunol 63:161–172PubMed

52.

Kollipara A, George C, Hanger J, Loader J, Polkinghorne A, Beagley K, Timms P (2012) Vaccination of healthy and diseased koalas (Phascolarctos cinereus) with a Chlamydia pecorum multi-subunit vaccine: evaluation of immunity and pathology. Vaccine 30:1875–1885PubMed

53.

Denner J, Norley S, Kurth R (1994) The immunosuppressive peptide of HIV-1: functional domains and immune response in AIDS patients. Aids 8:1063–1072PubMed

54.

Ishida Y, McCallister C, Nikolaidis N, Tsangaras K, Helgen KM, Greenwood AD, Roca AL (2015) Sequence variation of koala retrovirus transmembrane protein p15E among koalas from different geographic regions. Virology 475:28–36PubMed

55.

Fiebig U, Keller M, Möller A, Timms P, Denner J (2015) Lack of antiviral antibody response in koalas infected with koala retroviruses (KoRV). Virus Res 198:30–34PubMed

56.

Olagoke O, Quigley BL, Eiden MV, Timms P (2019) Antibody response against koala retrovirus (KoRV) in koalas harboring KoRV-A in the presence or absence of KoRV-B. Sci Rep 9:12416PubMedPubMedCentral

57.

Abts KC, Ivy JA, DeWoody JA (2015) Immunomics of the koala (Phascolarctos cinereus). Immunogenetics 67:305–321PubMed

58.

Maher IE, Griffith JE, Lau Q, Reeves T, Higgins DP (2014) Expression profiles of the immune genes CD4, CD8β, IFNγ, IL-4, IL-6 and IL-10 in mitogen-stimulated koala lymphocytes (Phascolarctos cinereus) by qRT-PCR. PeerJ 2:e280PubMedPubMedCentral

59.

Lu W, Mehraj V, Vyboh K, Cao W, Li T, Routy JP (2015) CD4:CD8 ratio as a frontier marker for clinical outcome, immune dysfunction and viral reservoir size in virologically suppressed HIV-positive patients. J Int AIDS Soc 18:20052PubMedPubMedCentral

60.

Serrano-Villar S, Sainz T, Lee SA et al (2014) HIV-infected individuals with low CD4/CD8 ratio despite effective antiretroviral therapy exhibit altered T cell subsets, heightened CD8+ T cell activation, and increased risk of non-AIDS morbidity and mortality. PLoS Pathog 10:e1004078PubMedPubMedCentral

61.

Olagoke O, Miller D, Hemmatzadeh F et al (2018) Induction of neutralizing antibody response against koala retrovirus (KoRV) and reduction in viral load in koalas following vaccination with recombinant KoRV envelope protein. NPJ Vaccines 3:30PubMedPubMedCentral

62.

Puls RL, Emery S (2006) Therapeutic vaccination against HIV: current progress and future possibilities. Clin Sci (Lond) 110:59–71

63.

Groschel MI, Prabowo SA, Cardona PJ, Stanford JL, van der Werf TS (2014) Therapeutic vaccines for tuberculosis—a systematic review. Vaccine 32:3162–3168PubMed

64.

Waugh C, Khan SA, Carver S et al (2016) A prototype recombinant-protein based chlamydia pecorum vaccine results in reduced chlamydial burden and less clinical disease in free-ranging koalas (Phascolarctos cinereus). PLoS ONE 11:e0146934PubMedPubMedCentral

65.

Kita Y, Hashimoto S, Nakajima T et al (2013) Novel therapeutic vaccines [(HSP65+IL-12)DNA-, granulysin- and Ksp37-vaccine] against tuberculosis and synergistic effects in the combination with chemotherapy. Hum Vaccin Immunother 9:526–533PubMed

66.

Jindra C, Huber B, Shafti-Keramat S et al (2015) Attenuated recombinant influenza A virus expressing HPV16 E6 and E7 as a novel therapeutic vaccine approach. PLoS ONE 10:e0138722PubMedPubMedCentral

67.

Messer RJ, Dittmer U, Peterson KE, Hasenkrug KJ (2004) Essential role for virus-neutralizing antibodies in sterilizing immunity against Friend retrovirus infection. Proc Natl Acad Sci USA 101:12260–12265PubMedPubMedCentral

68.

Vaine M, Lu S, Wang S (2009) Progress on the induction of neutralizing antibodies against HIV type 1 (HIV-1). BioDrugs 23:137–153PubMedPubMedCentral

69.

Denner J (2013) Immunising with the transmembrane envelope proteins of different retroviruses including HIV-1: a comparative study. Hum Vaccin Immunother 9:462–470PubMed

70.

Osterhaus A, Weijer K, UytdeHaag F, Knell P, Jarrett O, Akerblom L, Morein B (1989) Serological responses in cats vaccinated with FeLV ISCOM and an inactivated FeLV vaccine. Vaccine 7:137–141PubMed

71.

Fiebig U, Dieckhoff B, Wurzbacher C, Möller A, Kurth R, Denner J (2015) Induction of neutralizing antibodies specific for the envelope proteins of the koala retrovirus by immunization with recombinant proteins or with DNA. Virol J 12:1–8

72.

Tsukiyama-Kohara K, Kohara M (2014) Tupaia belangeri as an experimental animal model for viral infection. Exp Anim 63:367–374PubMedPubMedCentral

73.

Xu W, Gorman K, Santiago JC, Kluska K, Eiden MV (2015) Genetic diversity of koala retroviral envelopes. Viruses 7:1258–1270PubMedPubMedCentral

Titel: Koala retrovirus epidemiology, transmission mode, pathogenesis, and host immune response in koalas (Phascolarctos cinereus): a review
verfasst von: Mohammad Enamul Hoque Kayesh
Md Abul Hashem
Kyoko Tsukiyama-Kohara
Publikationsdatum: 08.08.2020
Verlag: Springer Vienna
Erschienen in: Archives of Virology / Ausgabe 11/2020
Print ISSN: 0304-8608
Elektronische ISSN: 1432-8798
DOI: https://doi.org/10.1007/s00705-020-04770-9

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