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Odontology

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05.02.2016 | Original Article

Effects of dentifrices differing in fluoride compounds on artificial enamel caries lesions in vitro

verfasst von: R. J. Wierichs, H. Zelck, C. E. Doerfer, P. Appel, S. Paris, M. Esteves-Oliveira, H. Meyer-Lueckel

Erschienen in: Odontology | Ausgabe 1/2017

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Abstract

The aim of this study was to compare the caries-preventive effect of a stabilized stannous fluoride/sodium fluoride dentifrice containing sodium hexametaphosphate with those of a regular, solely sodium fluoride-containing and amine fluoride-containing dentifrice on pre-demineralized bovine enamel specimens using a pH-cycling model. Bovine enamel specimens with two artificial lesions each were prepared. Baseline mineral loss of both lesions was analyzed using transversal microradiography (TMR). Eighty-five specimens with a mean (SD) baseline mineral loss of 3393 (683) vol% × µm were selected and randomly allocated to five groups (n = 13/15). Treatments during pH-cycling (28 days and 2 × 20 min demineralization/day) were: brushing twice daily with slurries of AmF (1400 ppm F⁻), NaF (1450 ppm F⁻), SnF₂/NaF (1100 ppm F⁻/350 ppm F⁻), and fluoride-free (FF) dentifrices or they were immersed in distilled water and remained unbrushed (NB). Subsequently, from each specimen one lesion was covered with acid-resistant varnish, while the remaining lesion was demineralized for another 14 days. Differences in integrated mineral loss (∆∆Z) were calculated between values before and after pH-cycling (∆∆Z _E1) as well as before pH-cycling and after second demineralization (∆∆Z _E2) using TMR. Treatments AmF and NaF induced a significantly higher mineral gain (∆∆Z _E1/∆∆Z _E2) compared to treatments FF and NB (p < 0.05; ANOVA test). Except for treatments AmF and NaF no significant differences in mineral loss between before and after pH-cycling could be observed (p < 0.05; t test) [∆∆Z _E1: AmF:1563 (767); NaF:1222 (1246); SnF₂/NaF:258 (1259); FF:−52 (1223); NB:−151 (834)]. Both dentifrices with either AmF or NaF promoted remineralization, whereas SnF₂/NaF dentifrice did not promote remineralization in a biofilm-free pH-cycling model.

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Titel: Effects of dentifrices differing in fluoride compounds on artificial enamel caries lesions in vitro
verfasst von: R. J. Wierichs
H. Zelck
C. E. Doerfer
P. Appel
S. Paris
M. Esteves-Oliveira
H. Meyer-Lueckel
Publikationsdatum: 05.02.2016
Verlag: Springer Japan
Erschienen in: Odontology / Ausgabe 1/2017
Print ISSN: 1618-1247
Elektronische ISSN: 1618-1255
DOI: https://doi.org/10.1007/s10266-016-0233-x

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