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Japanese Journal of Ophthalmology

Erschienen in:

01.07.2014 | Clinical Investigation

Relationship between retinal morphological findings and autoantibody profile in primary Sjögren’s syndrome

verfasst von: Jee Myung Yang, Hwan Heo, Sang Woo Park

Erschienen in: Japanese Journal of Ophthalmology | Ausgabe 4/2014

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Abstract

Purpose

To investigate the morphological changes of the retina measured with the Cirrus high-definition optical coherence tomography in patients with primary Sjögren’s syndrome (pSS).

Methods

One hundred ninety six eyes of 196 patients with pSS and 200 eyes of 200 age and sex-matched normal controls were enrolled. Patients with pSS were divided into four subgroups based on their presence of autoantibodies (antinuclear antibody (ANA), anti-Ro/SSA, and anti-La/SSB). Peripapillary retinal nerve fiber layer (pRNFL) thickness, macular ganglion cell-inner plexiform layer (mGCIPL) thickness, and optic nerve head parameters were compared between groups.

Results

Compared with controls, a significant decrease was observed in the average, inferior, and temporal thicknesses of pRNFL and in the minimum, superotemporal, inferonasal, inferior, and inferotemporal thicknesses of mGCIPL of eyes with pSS (all P < 0.05). In subgroup analyses, all eyes with positive tested autoantibodies [ANA(+), anti-Ro/SSA(+), anti-La/SSB(+)] showed a significant decrease of mGCIPL thicknesses, except for the superonasal portion, compared with eyes with any positivity for autoantibody (all P < 0.05). There was a negative linear relationship between the number of positive autoantibodies and average and inferior pRNFL thicknesses or all mGCIPL parameters, except for the superonasal portion, with a Spearman correlation analysis in patients with pSS (all P < 0.05).

Conclusions

Compared with controls, eyes with pSS showed thinning of pRNFL and mGCIPL thicknesses. The degree of thinning correlated with increased numbers of the positive autoantibody.

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Titel: Relationship between retinal morphological findings and autoantibody profile in primary Sjögren’s syndrome
verfasst von: Jee Myung Yang
Hwan Heo
Sang Woo Park
Publikationsdatum: 01.07.2014
Verlag: Springer Japan
Erschienen in: Japanese Journal of Ophthalmology / Ausgabe 4/2014
Print ISSN: 0021-5155
Elektronische ISSN: 1613-2246
DOI: https://doi.org/10.1007/s10384-014-0327-3

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