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19.01.2021 | Note

Bisindole alkaloids from Voacanga grandifolia leaves

verfasst von: Alfarius Eko Nugroho, Yurika Ono, Eunji Jin, Yusuke Hirasawa, Toshio Kaneda, Abdul Rahman, Idha Kusumawati, Takahiro Tougan, Toshihiro Horii, Noor Cholies Zaini, Hiroshi Morita

Erschienen in: Journal of Natural Medicines | Ausgabe 2/2021

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Abstract

Two new bisindole alkaloids, 12′-O-demethyl-vobtusine-5-lactam and isovobtusine-N-oxide (1 and 2), were isolated from the leaves of Voacanga grandifolia, together with two known bisindole alkaloids. Their structures were elucidated on the basis of 1D and 2D NMR data. 1 and 2 showed potent antimalarial activity against Plasmodium falciparum 3D7 and very low cytotoxic activity against a human cell line, HepG2 cells.

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Titel: Bisindole alkaloids from Voacanga grandifolia leaves
verfasst von: Alfarius Eko Nugroho
Yurika Ono
Eunji Jin
Yusuke Hirasawa
Toshio Kaneda
Abdul Rahman
Idha Kusumawati
Takahiro Tougan
Toshihiro Horii
Noor Cholies Zaini
Hiroshi Morita
Publikationsdatum: 19.01.2021
Verlag: Springer Singapore
Erschienen in: Journal of Natural Medicines / Ausgabe 2/2021
Print ISSN: 1340-3443
Elektronische ISSN: 1861-0293
DOI: https://doi.org/10.1007/s11418-020-01475-w

Die Highlights vom Kongress des American College of Cardiology 2024

Springer Medizin

Bisindole alkaloids from Voacanga grandifolia leaves

Abstract

Graphical abstract

Die Highlights vom Kongress des American College of Cardiology 2024

Springer Medizin

Abstract

Graphical abstract

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