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06.04.2021 | Original Paper

Two new bisindole alkaloids from Tabernaemontana macrocarpa Jack

verfasst von: Puteri Amelia, Alfarius Eko Nugroho, Yusuke Hirasawa, Toshio Kaneda, Takahiro Tougan, Toshihiro Horii, Hiroshi Morita

Erschienen in: Journal of Natural Medicines | Ausgabe 3/2021

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Abstract

Two new bisindole alkaloids, bisnaecarpamines A (1) and B (2), possessing a vobasine-sarpagine type skeleton were isolated from the bark of Tabernaemontana macrocarpa Jack. Their structures were elucidated by extensive spectroscopic methods and chemical correlation. The absolute configurations of compounds 1 and 2 were established using TDDFT-ECD calculation of the selected isomers. Bisnaecarpamine A exhibited potent antimalarial activity against Plasmodium falciparum 3D7 strain with IC₅₀ value of 28.8 µM.

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Titel: Two new bisindole alkaloids from Tabernaemontana macrocarpa Jack
verfasst von: Puteri Amelia
Alfarius Eko Nugroho
Yusuke Hirasawa
Toshio Kaneda
Takahiro Tougan
Toshihiro Horii
Hiroshi Morita
Publikationsdatum: 06.04.2021
Verlag: Springer Singapore
Erschienen in: Journal of Natural Medicines / Ausgabe 3/2021
Print ISSN: 1340-3443
Elektronische ISSN: 1861-0293
DOI: https://doi.org/10.1007/s11418-021-01510-4

Die Highlights vom Kongress des American College of Cardiology 2024

Springer Medizin

Two new bisindole alkaloids from Tabernaemontana macrocarpa Jack

Abstract

Graphic abstract

Die Highlights vom Kongress des American College of Cardiology 2024

Springer Medizin

Abstract

Graphic abstract

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