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05.05.2022 | Original Paper

Chukranoids A–I, isopimarane diterpenoids from Chukrasia velutina

verfasst von: Alfarius Eko Nugroho, Masaki Tange, Sumi Kusakabe, Yusuke Hirasawa, Osamu Shirota, Michiyo Matsuno, Hajime Mizukami, Takahiro Tougan, Toshihiro Horii, Hiroshi Morita

Erschienen in: Journal of Natural Medicines | Ausgabe 4/2022

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Abstract

Bioactivity guided separation of Chukrasia velutina root methanolic extract led to the isolation of nine new isopimarane diterpenoids, chukranoids A–I (1–9). The absolute configuration was then assigned by comparing the experimental CD spectra and the calculated CD spectra. Chukranoids A–I (1–9) showed moderate antimalarial activity against Plasmodium falciparum 3D7 strain. It seems that conjugate system in the isopimarane skeleton may influence their antimalarial activity.

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Titel: Chukranoids A–I, isopimarane diterpenoids from Chukrasia velutina
verfasst von: Alfarius Eko Nugroho
Masaki Tange
Sumi Kusakabe
Yusuke Hirasawa
Osamu Shirota
Michiyo Matsuno
Hajime Mizukami
Takahiro Tougan
Toshihiro Horii
Hiroshi Morita
Publikationsdatum: 05.05.2022
Verlag: Springer Nature Singapore
Erschienen in: Journal of Natural Medicines / Ausgabe 4/2022
Print ISSN: 1340-3443
Elektronische ISSN: 1861-0293
DOI: https://doi.org/10.1007/s11418-022-01623-4

Die Highlights vom Kongress des American College of Cardiology 2024

Springer Medizin

Chukranoids A–I, isopimarane diterpenoids from Chukrasia velutina

Abstract

Graphical abstract

Die Highlights vom Kongress des American College of Cardiology 2024

Springer Medizin

Abstract

Graphical abstract

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