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Archives of Osteoporosis

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01.12.2019 | Original Article

Increased risk of osteoporosis in patients with peptic ulcer: a follow-up study using a national sample cohort

verfasst von: Hyo Geun Choi, Chae Chun Rhim, Ji Young Yoon, Bum Jung Park, Chan Yang Min, Suk Woo Lee

Erschienen in: Archives of Osteoporosis | Ausgabe 1/2019

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Abstract

Summary

We performed a nationwide, population-based cohort study to investigate the risk of osteoporosis in patients with peptic ulcer disease in South Korea and concluded that peptic ulcer disease is associated with an increased risk of osteoporosis.

Purpose

This study aimed to evaluate the association between peptic ulcer disease (PUD) and the occurrence of osteoporosis using a national sample cohort from South Korea.

Methods

Using the national cohort study from the Korean National Health Insurance Service, we extracted data for patients with PUD (n = 50,002) and for 1:1 matched control participants (n = 50,002); we then analyzed the occurrence of osteoporosis from 2002 to 2013. The patients were matched according to age, sex, income, region of residence, and past medical history. A stratified Cox proportional hazards model was used to analyze the hazard ratios (HRs) and the 95% confidence intervals (CIs). Subgroup analyses were performed based on age and sex.

Results

The adjusted HR for osteoporosis was 1.36 (95% CI = 1.33–1.40, P < 0.001) in the PUD group. In the subgroup analysis based on age and sex, the respective adjusted HRs of PUD for osteoporosis were 1.33 (95% CI = 1.21–1.47) in the < 65-year-old group of men and 1.42 (95% CI = 1.30–1.56) in the ≥ 65-year-old group of men (each P < 0.001). The respective adjusted HRs of PUD for osteoporosis were 1.34 (95% CI = 1.29–1.39) in the < 65-year-old group of women and 1.38 (95% CI = 1.33–1.47) in the ≥ 65-year-old group of women (each P < 0.001).

Conclusion

In the current nationwide cohort study, we found that PUD is associated with an increased risk of osteoporosis regardless of sex.

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Titel: Increased risk of osteoporosis in patients with peptic ulcer: a follow-up study using a national sample cohort
verfasst von: Hyo Geun Choi
Chae Chun Rhim
Ji Young Yoon
Bum Jung Park
Chan Yang Min
Suk Woo Lee
Publikationsdatum: 01.12.2019
Verlag: Springer London
Erschienen in: Archives of Osteoporosis / Ausgabe 1/2019
Print ISSN: 1862-3522
Elektronische ISSN: 1862-3514
DOI: https://doi.org/10.1007/s11657-019-0659-1

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