There is ongoing debate about the management of medial epicondyle fractures in the pediatric population. This systematic review evaluated non-operative versus operative treatment of medial epicondyle fractures in pediatric and adolescent patients over the last six decades.
Methods
A systematic review of the available literature was performed. Frequency-weighted mean union times were used to compare union rates for closed versus open treatments. Moreover, functional outcomes and range-of-motion variables were correlated with varying treatment modalities. Any complications, including ulnar nerve symptoms, pain, instability, infection, and residual deformity, were cataloged.
Results
Fourteen studies, encompassing 498 patients, met the inclusion/exclusion criteria. There were 261 males and 132 female patients; the frequency-weighted average age was 11.93 years. The follow-up range was 6–216 months. Under the cumulative random effects model, the odds of union with operative fixation was 9.33 times the odds of union with non-operative treatment (P < 0.0001). There was no significant difference between operative and non-operative treatments in terms of pain at final follow-up (P = 0.73) or ulnar nerve symptoms (P = 0.412).
Conclusions
Operative treatment affords a significantly higher union rate over the non-operative management of medial epicondyle fractures. There was no difference in pain at final follow-up between operative and non-operative treatments. As surgical indications evolve, and the functional demands of pediatric patients increase, surgical fixation should be strongly considered to achieve stable fixation and bony union.
Introduction
Humeral medial epicondyle fracture management in the pediatric population continues to remain a topic of debate. Epidemiologically speaking, they account for nearly 12% of all elbow fractures [1] and are, therefore, not uncommon injuries.
A sub-section of these injuries need operative intervention. The indications for these are well documented and include open fractures and intra-articular incarceration of fractured fragments with an often subluxated elbow [1]. Relative surgical indications include associated ulnar nerve dysfunction and gross elbow instability [2, 3]. What intrigues most clinicians are cases that do not clearly meet the above distinct surgical indications. There is no question that the existing literature, in many ways, is responsible for this dispute. Traditional teaching has been that medial epicondyle fractures may be successfully managed non-operatively with good or excellent functional results, even when healed with fibrous union [4]. In recent years, there is growing consensus that those fractures that exhibit greater displacement (>2 mm) may benefit from open reduction and internal fixation [5‐7], while fractures that are non- or minimally displaced (generally <2 mm) may be treated non-operatively [1, 8] with good functional outcomes. Interestingly, there are several studies which report that the results are not significantly different with surgical and non-surgical modalities of treatment [9‐12].
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The athletic and functional demands that adolescents and teenagers place on their elbows continue to rise in most parts of the world. Anatomical reduction, early mobilization, and quick, full functional restoration is almost an undeclared expectation from patients, parents, and athletic trainers. Increasingly, patients with high-functional or athletic demands and displaced epicondylar fractures may represent another potential operative indication [1, 13].
Although our understanding of the elbow anatomy and role of its primary and secondary stabilizers has dramatically improved in the past few decades, several questions related to the management of medial epicondyle fractures in the pediatric population remain unanswered: what are the long-term outcomes of treating these fractures with non-operative methods versus operative stabilization? Is there any difference in the rates of bony union with these methods, and, if so, does it really matter? Does the degree of displacement and associated instability matter in decision-making? Are there any specific complications related to either treatment methodologies, and, if so, do they matter in the decision-making?
In the face of technical advancements, evolving surgical indications, and societal pressures, there is little concrete data demonstrating the superiority of either operative or non-operative treatment. Interestingly, from an academic standpoint, this topic begs for a prospective, randomized controlled study. The purpose of this study was to critically examine the outcomes of operative and non-operative treatment of medial epicondyle fractures and to present an evidence-based synthesis of the available literature. We hypothesize that operative fixation of medial humeral epicondyle fractures will be associated with greater union rates than non-operative treatment. We also hypothesize that functional and pain measures from both methods will be acceptable. We suspect, based on the rising interest in this topic, that an increasing trend exists towards the operative treatment of these injuries.
Methods
We searched the Medline, EMBASE, and Cochrane computerized literature databases from January 1950 to March 2009 for articles using the following search terms: medial epicondyle fracture(s); medial epicondylar fracture(s); medial apophyseal fracture(s). Reference lists from the articles retrieved were further scrutinized as well to identify any additional studies of interest. All studies from the above-mentioned searches were then reviewed.
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Studies were included in this systematic review if they met the following criteria: (1) they were in English, (2) they had a level I–IV study design by The Journal of Bone and Joint Surgery criteria (because the majority of studies in the clinical orthopedic literature are retrospective studies of level III–IV evidence, our goal was to be inclusive), (3) patients in the study had a medial epicondyle fracture, (4) there were a minimum of 14 medial epicondyle fracture patients in the study, (5) all patients included in the study were less than 18 years old, or those younger than 18 years if age could be individually analyzed, (6) there was a distinct treatment and/or outcome, and (7) studies were published in or after 1950. Two authors performed the initial search (AK, JH) and three of the authors (AK, KB, JH) independently reviewed the results and selected the appropriate studies based on the above criteria.
We obtained 93 articles from Medline, six from Cochrane, and 110 from EMBASE. Ninety-seven studies were found to be in duplicate among the database searches. This left 112 articles of potential interest. Thirty-six articles were excluded because they did not fulfill the inclusion criteria of having at least 14 pediatric subjects undergoing treatment for medial epicondyle fracture, including case reports and technical articles without extractable data regarding medial epicondyle treatment [9, 14‐48]. Twenty-six articles were review articles or epidemiologic or other studies without a primary treatment arm, or were otherwise unable to extract treatment data regarding medial epicondyle fractures [4, 8, 49‐72]. Twenty-five articles were excluded for chronic injuries or injuries unrelated to medial epicondyle fractures [73‐97]. Seven papers were excluded because they did not fulfill the pediatric population criteria [2, 98‐103]. Five articles were primary radiographic articles with no focus on the treatment of medial epicondyle fractures [104‐108].
A review of the bibliographies of the 14 remaining studies [3, 5‐7, 10‐12, 109‐115] was done by the reviewing authors, who selected articles to be further evaluated for potential inclusion. Nineteen additional publications were identified via this method and the text of each paper was subsequently reviewed; none of the articles found in this second-level search were able to fulfill the inclusion criteria. Four of these 19 papers were excluded for being review articles [115‐118]. Six were excluded because of their publication prior to 1950 [119‐124]. Five of these papers had less than 14 subjects in a medial epicondyle treatment group [125‐129]. Three of these papers had data that was unable to be extracted for medial epicondylar fractures and were excluded [130‐132]. One article focused on chronic epicondylar fracture management and was excluded [133]. Once all of these exclusions were performed, we were again left with 14 articles that fulfilled all of the inclusion criteria [3, 5‐7, 10‐12, 109‐115].
Treatment of fractures
Nine studies included non-operative treatment, which consisted of immobilization, with or without closed reduction of the fragment [3, 5, 10‐12, 110‐113]. One study managed patients exclusively with closed techniques [11]. A total of 156 patients were treated by non-operative methods. Eight studies had patients treated both by operative as well as non-operative treatment [3, 5, 10, 12, 110‐113]. Five studies had patients treated only with operative means [6, 7, 108, 109, 114]. Operative treatments included Kirschner wires [5‐7, 10, 12, 108‐110, 112‐114], screw fixation [5, 7, 12, 109, 111, 112, 114], suture [5, 12, 109‐111], excision of the fragment and suturing of the soft tissue to the periosteum of the medial elbow [10], tension band wiring [109, 112], Palmer pins [7, 110], closed reduction and percutaneous pinning [6], or open reduction alone [3]. In total, 321 patients received some type of operative treatment.
Indications for surgery
Indications for surgery were varied among the studies investigated. Nine studies did not specify operative indications [3, 5‐7, 10‐12, 110, 111]. Lee et al. [109] had indications which included fractures with >5 mm of displacement, a positive stress test under anesthesia, or a patient who required a stable elbow for participation in their sport. Two studies performed surgery when the medial epicondyle fracture was associated with dislocation of the humero-ulnar joint [113, 114]. Four studies performed surgery on significantly displaced fractures [11, 108, 112, 113], though significant displacement was variable in its definition. One used ulnar nerve symptoms as an indication for surgery [108]. Fowles et al. [5] did not mention what their indications were, but concluded that surgery was indicated only for patients with intra-articular entrapment of the fragment or significant displacement after closed reduction. While associated elbow dislocation was cataloged in a number of the studies, due to the inconsistent identification of which particular patients suffered dislocations, we were unable to perform subgroup analysis.
Statistical analysis
We considered pseudarthrosis, fibrous union, or fibrous non-union as a non-united fracture. Yates’ Chi-square test was used to determine if there were differences in the pooled union rates or pain rates at final follow-up when operative treatment was compared to non-operative treatment. Frequency-weighted means were used to determine the average ages of the patients involved in the study. Ulnar nerve symptoms, deformity, and functional outcomes were analyzed descriptively. Ulnar nerve symptoms were given as an indication for surgery in several studies [e.g., 114], and, hence, it would be inappropriate to apply meta-analytic statistical analysis to them (because, by definition, they would occur more often in the operative group). Deformity was often poorly described and inconsistently documented; as such, we described the findings of the individual studies in our results. Many different definitions of ‘excellent’ or ‘good’ outcomes were described for clinical scoring. As such, it would have been inappropriate to pool this data for the purposes of analysis. Funnel plots were also created to assess for publication bias; reasonably symmetric plots were found, so we concluded that no significant publication bias by small study effects existed. We also regressed the number of operative and non-operative patients by year of publication to assess for publication bias by year; this regression found no significant publication bias by year (P = 0.890 and 0.104, respectively), though there was subjectively a decreasing number of patients treated operatively in later years. Methods of fixation, length of follow-up, and other variables were significantly variable between studies; therefore, a random effects model was constructed using the DerSimonian and Laird model to assess the difference in union rates between operative and non-operative patients in studies which included both types, and pain in operative versus non-operative patients in studies which included both types. Meta-analytic statistics were calculated with MIX software (Kitasato Research Center, Sagamihara, Kanagawa, Japan) [134‐136]; other statistics were calculated with the SPSS package (version 15.0, SPSS Inc., Chicago, IL).
Results
Demographics
We found 14 studies that met all of our inclusion criteria and none of our exclusion criteria. Overall, there were 498 patients with a medial epicondyle fracture. Of those 498, there were 459 who were followed up and had enough data to be included in the individual studies. Table 1 highlights the demographics of the patients in the studies. There were 261 males and 132 female patients; the frequency-weighted average age was 11.93 years. The average follow-up in the various studies ranged between 6 and 216 months.
Table 1
Demographic characteristics of each study’s population
cUnclear from text how many received each treatment
dTransepiphyseal (Salter–Harris type II) fracture treated with Palmer nails
eTwenty-three epicondyle fractures (one chronic) and one distal humeral epiphyseal (Salter–Harris type II) fracture
fOnly 19 of 20 patients had information about treatment
gNo specific numbers given; listed as 5:1 ratio of male to female patients
Bony union
Table 2 highlights the findings of each individual study. Two hundred and sixty of 281 (92.5%) patients who received operative treatment had bony union at final follow-up. This was as compared to 60 of 122 (49.2%) patients treated non-operatively. This was statistically significant (P < 0.001). Pimpalnerkar et al. found the lowest rate of union in operatively treated fractures. Only six of 14 fractures (43%) went on to union; it is unclear why this was the case in this study. All other union rates for operatively treated medial epicondyle fractures were between 84.6 and 100% [5‐7, 10, 12, 109‐111, 113]. Non-operatively treated medial epicondyle fractures were associated with union rates of between 0 and 90% [3, 5, 10‐12, 110, 111, 113]. Seven studies [5, 10, 12, 110‐113] were eligible for pooling, because they had both operative and non-operative patients. Under the cumulative random effects model, the odds of union with operative fixation was 9.33 (2.54, 34.29) times the odds of union with non-operative treatment (P < 0.0001; see Fig. 1).
Table 2
Union rates and pain post treatment with operative versus non-operative treatment
aThe six patients who were treated with excision of the fragment were eliminated because union was not a goal for this surgery and there was nothing to unite
bTwelve patients in this study were not examined in person, but instead filled out questionnaires
cOne patient was initially assigned to the operative group based on displacement but refused surgery
d51.6% of patients had non-union, but were not broken down into operative and non-operative. 2% of patients had tenderness; no data for pain
eBased on seven studies that had both operative and non-operative patients with union data, random effects cumulative model
fBased on five studies that had data, random effects model
Fig. 1
DerSimonian and Laird random effects cumulative odds of union with operative treatment versus non-operative treatment. *Did not include fracture excision patients as union of the fracture was not a goal of treatment
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Pain
Thirty-seven of 246 (15%) patients who were operatively treated had pain or tenderness at final follow-up. This compares to ten of 115 (8.7%) patients who were treated non-operatively. The pooled difference in pain post-treatment was not significant (P = 0.140). Farsetti et al. had a subgroup of patients treated with excision of the osseous fragment and re-approximation of the soft tissues. Four out of six of these patients had persistent pain and two had osteoarthritis of the elbow [10]. Five studies [5, 10, 12, 111, 113] had both operative and non-operative patients and data about pain at final follow-up. A random effects model was constructed around these five studies. The odds of pain at final follow-up for patients treated operatively was 1.87 (0.21, 16.37) times the odds of those treated non-operatively; this was not statistically significant (P = 0.73).
Ulnar nerve symptoms
Table 3 highlights the ulnar nerve symptoms reported in each study. For studies which followed ulnar nerve symptoms and specified pre-operative nerve status [3, 5, 6, 11, 12, 108, 109, 111, 113, 114], 37 of 384 (9.6%) patients had ulnar nerve symptoms. Twenty-five of 231 (10.8%) patients treated operatively had ulnar nerve symptoms pre-operatively; two of 103 (1.9%) patients treated non-operatively had ulnar nerve symptoms pre-operatively. At final follow-up, 16 of the 409 (3.9%) total number of patients, 13 of 287 (4.5%) patients treated operatively, and three of 122 (2.5%) patients treated non-operatively had ulnar nerve symptoms. The difference was not statistically significant (P = 0.412). Some authors treated patients with ulnar nerve symptoms with ulnar nerve transposition intra-operatively [5], while others did not routinely perform this treatment.
Table 3
Ulnar nerve symptoms following medial epicondyle fracture
Authors
Ulnar nerve symptoms total (all groups) pre-intervention
Ulnar nerve symptoms total pre-operative
Ulnar nerve symptoms total pre-non-operative
Ulnar nerve symptoms total (all groups) at final follow-up
Ulnar nerve symptoms total at final follow-up, operative
Ulnar nerve symptoms total at final follow-up, non-operative
Eight studies reported functional outcomes in either outcome scores or by categorizing patients as ‘excellent,’ ‘good,’ ‘fair,’ or ‘poor’ based on various criteria. Haxhija et al. [108] used the criteria of axial deviation less than 9°, range-of-motion deficiency of less than 19°, minimal strength or functional loss, and no pain as their criteria for a good or excellent outcome; all patients in their study underwent open reduction and internal fixation with K-wires. Lee et al. used the Elbow Assessment Score of the Japanese Orthopedic Association, a 100-point score where 100 points corresponds to the best possible score. At final follow-up, the average score was 96.2 points (89–100). These authors used K-wires, screws, tension band wire, or suture to fix their fractures [109]. Farsetti et al. used the criteria of no symptoms, no atrophy, no osteoarthritis, negative valgus stress, and less than 10° motion loss as their criteria for good or excellent results. Sixteen of 19 non-operative patients and 15 of 17 operative patients had a good result. The remainder of the patients in these two groups had a fair result. Six patients were treated with excision of the osseous fragment and the repair of soft tissues. This was associated with two of six fair results and four of six poor results [10]. Bede et al. [3] classified results as good if, subjectively, the elbow was functional, pain-free, and free from instability or deformity, and, objectively, the range of motion was limited by 15° or less, there was less than 6° of cubitus valgus, and no ulnar neuritis. If these criteria were not met, the result was considered to be poor. Bede et al. [3] found that ten of 16 patients who had operative treatment had good results, compared to 27 of 34 patients who had non-operative treatment. The remainder of the results was poor. Hines et al. also used Bede’s criteria. However, they found 23 of 24 of their operatively treated patients to have experienced good outcomes [6]. The patient who did not have a good outcome was reported to have had a painful non-union [6]. Skak et al. [110] defined excellent outcomes as full range of motion, normal appearance, and no symptoms; good outcome as less than 15° of range of motion loss, minor deformity, and no arthritic or neurologic symptoms; poor outcome included disabling loss of motion, noticeable deformity, or any arthritic or neurologic symptoms. Eighteen of 21 of their operatively treated patients and two of three of non-operatively treated patients had good or excellent outcomes. The outcome was poor in the remainder of the patients [110]. The poor results were due to ulnar neuritis in two patients, an extension lag in one patient, and deformity due to a concomitant lateral condyle fracture [110]. Ip and Tsang [112] used the Mayo Clinic Score, which has 45 points for pain, 10 points for stability, 20 points for range of motion, and 25 points for activities of daily living. Four patients were treated conservatively; their Mayo scores at follow-up ranged from 90 to 100 (average 96.25). Overall, patients who underwent operative treatment had Mayo scores that ranged from 80 to 100 (average 93) [112].
Range of motion or strength restriction
Haxhija et al. [108] had two operative patients with flexion deficits of 5° at 1 year and one with 10° of flexion deficit; two patients had slight loss of strength. Bede et al. [3] reported 71% of patients with limited range of motion, though what was specifically meant by this was not indicated. The series by Fowles et al. [5] noted that eight of 19 patients treated non-operatively lost an average of 15° of elbow range of motion, and six of nine patients lost an average of 37° of range of motion. Dias et al. [11] found that eight of 20 patients lost less than 20° of flexion or extension and one lost more than 20°. Wilson et al. [12] found that two of 23 of their operative patients and six of 20 of their non-operative patients lost greater than 10° of extension, though this was not significantly different. Papavasiliou and Crawford [113] reported no loss of range of motion or strength in any patient. Hines et al. [6] only noted loss of motion (of less than 15°) in patients who required arthrotomy to remove the osseous fragment; the remainder of their operative and non-operative patients did not lose significant motion. Farsetti et al. [10], in their long-term follow-up, found two non-operative patients with limitations of elbow extension of 5 and 10°, two internal fixation patients with limitations of 5 and 20°, and one patient who had excision of their fragment with loss motion of 30° of extension. One of these non-operative patients had 1.5 cm of forearm atrophy; four patients who had excision of the fragment had 1–3.5 cm of forearm atrophy, and three lost grip strength [10]. In the van Niekerk and Severijnen [111] series, two non-operatively treated patients lost 5° of extension, and three patients had a loss of strength. Seven operative patients lost between 4 and 18° of motion, and three lost strength. Pimpalnerkar et al. [114] found that nine of 14 operative patients lost 5–15° of extension (mean 6.4°) at a mean follow-up of 17.2 months. Lee et al. [109] reported only one patient who had decreased motion post-operatively (arc of motion 110°). Duun et al. [7] reported that seven of their operatively treated patients lost extension (5–25°), one lost supination (10°), and two lost flexion (5°). Ip and Tsang [112] reported no loss in motion or strength in either operatively treated or non-operatively treated patients.
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Deformity
Haxhija et al. [108] had one patient with slight valgus deformity of 14° compared to the contralateral elbow (11°). Bede et al. [3] reported 35.5% cubitus valgus, though the specific parameters for this deformity were not indicated. Wilson et al. [12] found no cubitus valgus in any patient treated operatively or non-operatively. Hines et al. [6] had two of 19 patients with significant valgus deformity (15–20°) post-operatively; both of these patients required excision of the intra-articular osseous fragment, followed by internal fixation. Farsetti et al. [10], in their long-term follow-up, found two patients with a valgus deformity. Of interest, only two of 19 non-operative fractures united; one resulted in a carrying angle of 32°. Skak et al. reported on a variety of deformities, which ranged from radiologic findings such as double-contoured epicondyle, ulnar sulcus, pseudarthrosis, hypoplasia, or hyperplasia. Only one of these was classified as severe and was due to avascular necrosis of the trochlea. This patient had a concomitant lateral condyle fracture [110]; the investigators were unable to correlate the deformity to a specific treatment. Lee et al. [109], Pimpalnerkar et al. [114], Papavasiliou and Crawford [113], and van Niekerk and Severijnen [111] did not report any valgus deformities. Ip and Tsang [112] reported one patient treated with K-wires who developed cubitus varus and a patient with a displaced fracture who refused surgery who developed cubitus valgus. In the Duun et al. [7] series of operatively managed medial epicondyle fractures, one patient had a valgus deformity of 5°.
Complications
Eight studies reported no complications related to the treatment of the medial epicondyle fracture which were not previously discussed in other sections of this paper [7, 11, 108‐111, 113, 114]. Bede et al. [3] reported one patient with septic arthritis post-operatively and one patient with myositis ossificans. Wilson et al. [12] had two wound infections in their operative group and one keloid scar. One patient in Hines et al.’s [6] series of operatively treated fractures had pins which missed the fracture fragment; this patient had valgus instability post-operatively. Three patients in the same series had pin-tract infections that resolved with antibiotics and local wound care [6]. One patient from the Ip and Tsang [112] series had tension band wire and K-wires that developed a superficial wound infection.
Discussion
The management of medial epicondyle fractures in the pediatric population continues to be a topic of deliberation. We embarked on this systematic review to synthesize the available data and to aid the clinician’s decision-making process based on existing evidence. The purpose of this study was to answer the following questions: What are the long-term outcomes of treating these fractures with non-operative methods versus operative stabilization? Is there any difference in the rates of bony union with these methods, and, if so, does it really matter? Does the degree of displacement and associated instability matter in decision-making? Are there any specific complications related to either treatment methodologies, and, if so, do they matter in the decision-making?
Non-operative management of these fractures has reported problems, including unrecognized incarcerated fragment, ulnar nerve dysfunction (10–16%, but up to 50% with an incarcerated fragment), tardy ulnar neuritis, malunion, loss of terminal extension, and discord between the patient and family expectations for high-functional activity and ultimate functional result [1, 13, 45]. Operative fixation has increased in most centers despite the lack of particular scientific evidence that patients do better with anatomic reduction. Anatomic, stable fixation remains a possible, albeit not yet proven, advantage in athletics and sports with heavy demand on the dominant elbow. Ironically, in spite of the scarcity of data, there exists a trend of decreasing numbers of non-operative cases/published series per 5-year period since the Bede study in the 1970s (Fig. 2).
Fig. 2
Year of publication regressed against the number of non-operative patients over the number of studies for each 5-year period. x-axis = year of publication; y-axis = number of patients/number of studies
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One possible explanation for this is that, under the cumulative random effects model in this study, the odds of union with operative fixation was 9.33 times the odds of union with non-operative treatment (P < 0.0001). Anatomic reduction is ensured with open reduction and internal fixation; therefore, it is not surprising that bony union was significantly different between operative and non-operative treatment. What is the significance of superior bony union afforded by surgical intervention? From the available data, one can only hypothesize that operative fixation may impart advantages from direct fracture reduction, restoration of the elbow anatomy and soft-tissue tension, protecting vital structures, including the ulnar nerve, and minimizing the risks of early or late re-displacement of the fracture fragment.
Historically, the purported benefits of closed treatment were satisfactory functional outcome without necessary bony union. Fibrous union alone provided satisfactory functional results in some studies [4], while other studies mention the occurrence of painful non-unions in these fractures. Proponents of surgical fixation, therefore, might point to patient dissatisfaction with late deformity, persistent stiffness, or recurrent instability as reasons for early surgical intervention. Importantly, operative fixation was found to provide a higher union rate, while both pain symptoms and ulnar nerve complications were not significantly different between the non-operative and operative groups.
Undoubtedly, there is subtle variation between study populations that may account for heterogeneous union rates, even among similar operative treatment modalities. Moreover, there is a baseline risk (that is not zero) of mal- or non-union, even with anatomic intra-operative bony apposition. Nevertheless, it is important to ask, then, why some non-unions resulted from operative treatment among the included studies. One possible explanation is that the use of K-wires or smooth pins for fixation could not achieve adequate compression in these failed cases (as this is mainly an avulsion injury that has a continued distractive muscular force across the fracture at all times). One can only hypothesize that those cases may have done better with compression fixation in terms of union.
One of the difficulties with discerning the treatment of this injury is the disparate classifications. Smith [130] originally described five types: 1: not apparent on X-ray, 2: minimally displaced, 3: significantly displaced, 4: incarcerated, and 5: a fracture of the medial humeral epicondyle in adults. Papavasiliou and Crawford [113] used a classification which is more often used today: Type 1: small degree of avulsion, Type 2: avulsed fragment at the level of the joint but not entrapped, Type 3: the fragment is incarcerated in the joint, and Type 4: associated with elbow dislocation. Since this classification system is somewhat unclear, the definition of type 1 and type 2 fractures varies between studies. This makes synthesis of the literature difficult, and also makes the indication of ‘displaced fracture’ somewhat confusing. Because of the lack of prospective comparative data, and the perceived benefit of increased elbow stability with bony union, the most plausible indications for surgical fixation seem to be ones suggested by Lee et al. [109]: fractures with >5 mm of displacement, a positive stress test under anesthesia, or a patient who requires a stable elbow for participation in their sport (Fig. 3).
Fig. 3
Proposed management algorithm for medial humeral epicondyle fractures
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Over the last several decades, our understanding of the complexities of elbow anatomy and medial epicondyle injuries/fractures has changed dramatically. Medial epicondyle injuries were traditionally considered as benign and insignificant extra/peri-articular fractures of the distal humerus. As we have furthered our understanding about elbow stability and the importance of full range of motion in elbow biomechanics, perspectives towards the treatment and management of these injuries are changing and will continue to change. Functional demand and athletic performance, which is increasingly the norm of today, were not clearly considered in many of the earlier studies. The intensity and duration of modern day sporting activities that push the functional demand of the elbow and shoulder to its maximum necessitate stable mechanics for optimal performance. The goals with operative fixation certainly are to maximize the possibility of early return to full function and high-level activity, and to minimize late deformity and the likelihood of stiffness (as with prolonged cast immobilization).
There are limitations in this study. We did not have access to much of the raw data for each study, which, in some ways, limited our analysis or prevented further stratification, including outcome according to operative treatment type. A systematic review of this nature is inherently limited by the heterogeneity of the individual studies in terms of range of motion analysis, outcome scoring systems, and cataloging of complications. Furthermore, problems with inference, including bias, confounding, and random chance inherent to the individual observational studies utilized in this review are not improved by pooling the data. Previous studies disagreed on how much displacement was acceptable, which makes it difficult to comment on the degree of displacement itself as an indication for surgery.
In summary, while the treatment of pediatric medial epicondyle fractures with open injuries, incarcerated fragments, and unstable elbows is not in question, further studies are necessary to determine the optimal treatment for patients with displaced and non-displaced fractures. Long-term data from the Farsetti et al. [10] study point to devastating results with medial epicondyle fragment excision. Our understanding of the role of the medial epicondylar fragment in overall elbow stability continues to evolve, and the effect of painful, symptomatic non-union is a real, although poorly understood, phenomenon.
Although we provide an algorithm based on this systematic review (Fig. 3), it is based on level III–IV evidence. Because there is ongoing debate over what constitutes the optimal treatment for type I and II fractures, a randomized controlled trial is both ethical and indicated. Operative treatment offers a superior rate of bony union when compared to non-operative care. In the pooled data, there was no difference in pain at final follow-up between both the operative and non-operative groups. Likewise, there was no statistically significant increase in the incidence of ulnar nerve complications with operative management. As the functional demands of young patients increase, the relative indications for surgical fixation must be carefully weighed.
Conflict of interest statement
There were no grants or external sources of funding utilized for this study.
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